1319results about "Ion sources/guns" patented technology

Systems and methods are described for collecting and combining multiple scan samples from a surface of a semiconducting wafer. A system embodiment includes, but is not limited to, a scan nozzle configured to introduce a first scan solution to a surface of a semiconducting wafer to remove impurities from the surface to provide a first scan sample and retrieve the first scan sample, the scan nozzle further configured to introduce a second scan solution to the surface of the semiconducting wafer to remove residual impurities from the surface to provide a second scan sample and retrieve the second scan sample; and a collection vessel in fluid communication with the scan nozzle, the collection vessel configured to receive each of the first scan sample and the second scan sample from the nozzle and to mix the first scan sample with the second scan sample to provide a combined scan sample.

A method of detecting one or more PFAS in a sample of animal tissue, comprising: spraying electrically charged solvent droplets onto the sample of animal tissue so as to generate analyte ions from analyte in the animal tissue; passing the analyte ions into a mass spectrometer; and mass analysing the analyte ions so as to determine if the one or more PFAS is in the animal tissue.

The invention relates to the technical field of instruments and meters, in particular to an inductively coupled plasma mass spectrometer system for intelligent data processing and report generation. Comprising a sample introduction unit, a plasma excitation and ionization unit, a mass analyzer and detection unit, a vacuum system unit and an intelligent data processing and report generation unit. Efficient ionization is achieved through a bipolar radio frequency switching and AI optimized reaction gas plasma source, the AI optimization module monitors in real time and dynamically adjusts parameters so that the ionization efficiency can be stabilized at 92% + / -2%, and meanwhile a reaction gas control system can optimize plasma conditions to suppress interference ions. And the mass analyzer and the detection unit realize high-precision ion separation by utilizing AI interference correction and a QMS-TOF double analyzer mode, and an interference elimination module can automatically eliminate polyatomic ion interference, so that the ionization efficiency, the analysis precision and the accuracy are improved, the interference is effectively inhibited, and the analysis capability of the system on a complex sample is enhanced.

The invention discloses a three-dimensional laser post-ionization-secondary neutron particle mass spectrometer which comprises a vacuum pool, a sample introduction system, a primary ion emission system, a three-dimensional laser post-ionization system, an ion optical system, a time-of-flight mass spectrometer, an observation system and a computer control system. By adjusting the wavelength, the frequency and the energy value of the laser, resonance between the energy of laser photons and the electron energy level of target molecules can be realized to realize selective ionization of substances, and the method has extremely high element, nuclide and molecule selectivity, can provide the sensitivity of an instrument, and can be used for mass spectrometry. The device can be applied to single-cell imaging analysis test of lipid, metabolites, small-molecule drugs and part of elements with the molecular weight smaller than 1000 Da, the problems of space metabolome small-molecule metabolite test and ultrahigh spatial resolution imaging are solved, and the device can be independently used as an SIMS when laser post-ionization is not used.

The invention discloses a discharge ionization source for an ion mobility spectrometry. The discharge ionization source is designed by adopting a low-temperature plasma discharge principle. A radio frequency electrode of the discharge ionization source is a rod-shaped metal electrode arranged in an inner cavity of the single-end-opened quartz glass tube, direct-current electrodes of the discharge ionization source are arranged on the outer wall face of the discharge glass tube body in an array mode at equal intervals, the potential of each direct-current electrode can be independently adjusted, and the direction of a direct-current electric field in the ionization source can be conveniently adjusted and controlled. The migration direction of the ions is further controlled; in addition, a plurality of gas interfaces are arranged on the quartz glass tube, so that the gas flow direction in the quartz glass tube and the components of the discharge gas can be regulated and controlled. Based on the structural design of the array type direct current discharge electrode and the multi-gas interface, the discharge ionization source takes air as discharge gas, can realize positive and negative ion mode switching, reaction reagent ion component switching and sample ionization mode switching, and is simple in structure, convenient to operate and suitable for the ion mobility spectrometer.

A machine, article, process of using, process of making, products produced thereby and necessary intermediates. Illustratively, there can be a process that includes: ionizing at least some injected gas to form ions; confining, without using magnetic fields, at least some of said ions to produce confined ions; accumulating at least some of said confined ions to produce accumulated ions; cooling at least some of said accumulated ions to produce cooled ions; compressing, without using magnetic fields, at least some of said accumulated ions to produce compressed ions; accelerating at least some of said compressed ions to produce accelerated ions; ejecting at least some of said accelerated ions; and measuring at least one property of said ejected ions.

A mass spectrometer includes an ion source unit including: a housing; a cover accommodating the housing; an enclosure accommodating the cover; a probe passing through the cover and the housing to nebulize a liquid sample into the housing; a heated gas nozzle including a main body portion being hollow and located between the cover and the housing to discharge a gas heated by a heater in the main body portion into the housing; enclosure intake and exhaust ports; cover intake and exhaust ports; a first exhaust fan to discharge air flowing from the cover intake port and passing through the cover through the cover exhaust port; and a second exhaust fan to discharge air discharged into the enclosure from the cover exhaust port and air flowing from the enclosure intake port and passing through the enclosure, to an outside through the enclosure exhaust port.

A hybrid inductively coupled plasma mass spectrometer (ICP-MS) system is disclosed for simultaneous elemental and molecular analysis in positive and negative polarities. It includes an ICP torch that generates plasma with a buffer gas, producing both positively and negatively charged ions from a sample. Positioned between the sampler and skimmer, an insert with a defined geometry forms a reaction chamber. Various embodiments feature multiple apertures for pressure control, a rotatable disk for aperture regulation, a slider gate for pressure adjustment, a circular gate with adjustable radial apertures, and an inlet for introducing gases, reagents, dopants, or analytes. These components enable precise pressure modulation, optimizing performance for dual-polarity mass spectrometry. The system enhances analytical flexibility by facilitating controlled ion reactions, improving sensitivity and specificity for both elemental and molecular applications. This innovation expands ICP-MS functionality, supporting diverse scientific and industrial applications requiring high-precision mass analysis.

The present invention discloses a method for analyzing sources of Cd / Pb combined polluted farmland soil using bimetallic isotopes (Cd—Pb), comprising the following steps: collecting respectively a soil sample and risk source samples through a sample collection device; determining respectively Cd isotope ratio and Pb isotope ratio of the soil sample and the risk source samples; plotting by using the Cd isotope ratio and the Pb isotope ratio of the soil sample and the risk source samples as coordinates, to obtain a projection plot of the isotope ratios; recognizing a pollution end-member polluting farmland soil through the projection plot of the isotope ratios to obtain a recognition result for the pollution end-member, and then confirming the pollution end-member; and calculating a relative contribution rate of the pollution end-member, to obtain an analysis result for the source of isotopes. The present invention uses the two metal isotopes of Cd—Pb to mutually restrict and confirm each other to solve the problem of poor analytical accuracy caused by similar or overlapping isotope values of samples and isotope fractionation, and realizes accurate recognition and quantitative analysis for the source of heavy metals Cd / Pb pollution of farmland soil.

The invention belongs to the technical field of online analysis of organic pollutants, and particularly relates to a device and a method for real-time online analysis of non-volatile organic pollutants. The device comprises a sample injection module, a vacuum ultraviolet lamp, an ionization source cavity, a repulsion electrode, an ion funnel, a mass analyzer and a vacuumizing module, the ionization source cavity is provided with a sample injection port, a vacuum extraction port and an ion output port, and the vacuum ultraviolet lamp, the repulsion electrode and the ion funnel are sequentially arranged in the ionization source cavity at intervals in the axis direction of the ion output port; the ion funnel is close to the ion output port; the sample injection module is arranged at the sample injection port; the vacuumizing module is arranged on the vacuum extraction opening; the ion output port is externally connected with a mass analyzer; a direct-current voltage is applied to the repulsion electrode, and a direct-current voltage and a radio-frequency voltage are applied to the ion funnel. According to the invention, the ions with relatively large initial distribution area can be focused, so that the detection sensitivity is further improved, and the detection requirements on trace non-volatile organic pollutants are met.

The invention discloses a composite ion source device for coupling atmospheric pressure interface orbitrap mass spectrometry, which belongs to the field of mass spectrometry detection and comprises a photo ionization / photo-induced association ionization ionization and ion transmission mechanism, a gas sample introduction mechanism, a high-flux radio frequency vacuum ultraviolet light source mechanism and an ion source and mass spectrometry interface mechanism. By adopting the composite ion source device for coupling the atmospheric pressure interface orbitrap mass spectrum, organic components with different polarities, ionization energy and ion affinity in a complex mixture can be efficiently ionized, and through reasonable structural design, the organic components are coupled with the high-resolution orbitrap mass spectrum with the atmospheric pressure interface, so that the high-resolution orbitrap mass spectrum is obtained. The detection range of complex organic components is widened, and the resolution capability and the detection sensitivity of low-abundance or high-molecular-weight organic components are improved.

The invention discloses a thermal desorption sample injection ion source with a separation function, which comprises an ionization cavity, and the top end of the ionization cavity is detachably connected with a heat insulation pad; the heating cavity is fixed to the top end of the heat insulation pad, and a mounting base is mounted at the bottom in the heating cavity; according to the sample injection system, a heating cavity comprises a sample injection unit installed at the top end of the heating cavity, a sample injection pipe is fixedly connected to an installation base, and the sample injection unit is communicated with the sample injection pipe through a sample separation column; the heating system is mounted on the mounting seat; the ionization unit is vertically fixed on one side wall of the ionization cavity, and the ionization unit and the sample feeding pipe are vertically arranged; the detection unit is vertically and fixedly connected to the other side wall of the ionization cavity; a waste liquid opening is formed in the bottom of the ionization cavity. According to the invention, the ionization competition of the target compound of the atmospheric pressure ionization source can be greatly reduced, the sensitivity and the quantitative stability are improved, and more accurate rapid detection is realized.

The invention discloses a sampling device for ICP-MS (Inductively Coupled Plasma Mass Spectrometry) in the technical field of instrumental analysis. The sampling device comprises a liquid inlet mechanism and an atomization mechanism, the liquid inlet mechanism is used for inputting a liquid sample into the atomization mechanism, the atomization mechanism comprises a concentric atomizer and an atomization chamber, the concentric atomizer is communicated with the atomization chamber, and the atomization chamber is communicated with a waste liquid barrel and an ICP torch pipe; a self-cleaning mechanism is arranged on a communication path of the concentric atomizer and the atomizing chamber, the self-cleaning mechanism comprises a movable cylinder, the movable cylinder is rotationally connected into a nozzle of the concentric atomizer, contact electrodes are symmetrically arranged in the movable cylinder, and when the movable cylinder is blocked, the contact electrodes form a path; the contact electrode is electrically connected with a torsion mechanism and a reverse blowing mechanism, the torsion mechanism is used for twisting the movable cylinder when the contact electrode forms a path, and the reverse blowing mechanism is used for intercepting carrier gas input into the concentric atomizer and reversely blowing the carrier gas out of a nozzle of the concentric atomizer. According to the invention, self-cleaning can be carried out when blockage occurs in the sample introduction process, and sample analysis interruption caused by blockage is reduced.

The invention provides an in-situ pyrolysis device adopting a glow ionization source. The in-situ pyrolysis device comprises a high-temperature pyrolysis device, a glow ionization device, a two-stage sampling cone, a quadrupole rod device and a flight time mass analyzer, the high-temperature pyrolysis device comprises a first copper block, a second copper block, a graphite sleeve and a long graphite pipe; the glow ionization device comprises a first electrode fixing cylinder, a second electrode fixing cylinder and an annular electrode; the two-stage sampling cone is divided into a first-stage sampling cone and a second-stage sampling cone; and the quadrupole rod device comprises four quadrupole rod electrodes which are parallel to one another and are symmetrically arranged. Pyrolysis reactants generate fullerene and intermediate products thereof through a high-temperature pyrolysis device, then product molecules are ionized through a glow ionization device, ionized ions pass through a two-stage sampling cone and are guided by a radio-frequency electric field and a direct-current electric field of a quadrupole rod device to reach a time-of-flight mass analyzer for in-situ mass spectrometric analysis, and the mass spectrometric analysis result is obtained. In-situ mass spectrometry analysis of'first ionization and second sampling 'can be realized, and fullerene and intermediates thereof formed by high-temperature pyrolysis can be captured.

A position control system may obtain image data representing one or more images depicting an inlet of a mass spectrometer and an emitter positioned near the inlet, and adjust a position of the emitter relative to the inlet to an optimal position at or near a reference position relative to the inlet based on the image data.

The invention relates to the technical field of vacuum equipment, and discloses an ion lens assembly, an ion source, a mass spectrometer and a mass spectrometry system. The ion lens assembly includes a deflection lens assembly and a return lens assembly. The deflection lens assembly is used for focusing an ion beam in the incident particle beam and enabling the ion beam to deflect towards a first direction. And the axis-returning lens assembly is used for receiving the ion beam from the deflection lens assembly, and the axis-returning lens assembly is used for focusing the received ion beam and enabling the ion beam to deflect towards a second direction.

The invention belongs to the technical field of mass spectrum ionization sources, provides an online detection mass spectrum ionization source for gas components at an outlet of a combustion chamber of an aero-engine, and solves the problem that an existing ionization source is difficult to be applied to a field test for measuring the concentration of components at the outlet of a combustion chamber of a real aero-engine. According to the technical scheme, the device comprises an ionization source cavity and a radio frequency windowless discharge lamp, a plate electrode, a taper hole electrode, a lamp holder electrode, a direct current transmission electrode, a radio frequency transmission electrode and a differential electrode are sequentially arranged in the ionization source cavity in the axis direction, and a discharge gas inlet is formed in the ionization source cavity. One end of the radio frequency windowless discharge lamp is connected to the discharge gas inlet, and the other end of the radio frequency windowless discharge lamp extends into the lamp holder electrode; the taper hole electrode enables fuel gas to be fed in a molecular beam mode, efficient transmission of stable components and active components in the fuel gas is guaranteed, efficient transmission of ions is achieved in the mode that the direct-current transmission electrode and the radio-frequency transmission electrode are combined, and full-spectrum online analysis of the components of the fuel gas at the outlet of a combustion chamber of an aero-engine can be achieved.

A method and corresponding devices to reduce the presence of unwanted ions within the pseudo-potential well of the RF fields for inductively coupled plasma mass spectrometry is disclosed. This method reduces space-charge effects and leaves more room available for the ions of interest and, hence, leads to increased transmission of the desired ions into the mass analyzer. In the present invention, the space charge is reduced by adding a low-band resolving DC potential, or a fast sweeping resolving DC potential with a notch, or a fast constant resolving DC potential with a notch, or by adding auxiliary quadrupolar or dipolar RF potential to the quadrupole ion guide, such that all the unwanted ions will be outside the stable region and therefore ejected. This reduces the charge density in the ion beam and ameliorate space charge effects.

The present invention relates to the field of analytical chemistry, and discloses a mass spectrum ionization element for macrolide antibiotic detection and a preparation method thereof, the mass spectrum ionization element comprises: a conductive substrate made of stainless steel; the adsorption layer is attached to at least part of the surface of the substrate, the adsorption layer is formed by a boric acid functionalized covalent organic framework, and the boric acid functionalized covalent organic framework is of a polycyclic structure composed of repeated units shown in the formula I in the specification. The mass spectrum ionization element is uniform in coating, high in selectivity on macrolide enriched antibiotics in a complex matrix and high in enrichment capacity, an eluent of the mass spectrum ionization element can be used for detection based on a liquid chromatography method and can also serve as a mass spectrum ion source solid substrate, mass spectrum detection is conducted through electrospray ionization, the detection steps are simple, and the mass spectrum ionization element is suitable for mass spectrum detection. And the detected background noise is low.

The invention provides a reactor and a dual-light-source mass spectrum device for in-situ detection of gas-phase species in a catalytic reaction. The reactor comprises a control part, a first tube body and a second tube body, the control part comprises a first shell and a switching piece; the first shell is provided with a first channel and a second channel which are arranged in the first direction. The switching piece is arranged between the first channel and the second channel; the first pipe body extends in the first direction and is located on the side, away from the second channel, of the switching piece. The first pipe body is communicated with the first channel; the second pipe body extends in the first direction and is partially located in the second channel. The second pipe body is connected with the first shell and can move in the first direction relative to the first shell. The switching piece moves relative to the first shell to control connection and disconnection of the first channel and the second channel. When the first channel communicates with the second channel, the second pipe body is allowed to partially extend into the second pipe body, and when the first channel is isolated from the second channel, the second pipe body is located on the side, away from the first channel, of the switching piece. The application of the reactor realizes material replacement on the premise of not breaking vacuum.

A system and method for determining a net source rock thickness is disclosed. The method includes obtaining at least one well log, a first and second plurality of core samples from a wellbore, and for each of the first plurality determining a relative abundance of inorganic materials, and for each of the second plurality a set of organic material data. The method further includes determining a validated total organic content and a measured source rock thickness based on the organic material data and relative abundance of inorganic materials and determining a data and a prediction portion of the wellbore, based on the second plurality sample locations. The method still further includes determining a cut-off value for each well log, predicting a source rock thickness from the cut-off values and the net source rock thickness from a sum of the predicted and the measured source rock thicknesses.

This disclosure pertains to compositions comprising an anti-FcRn antibody, M281. The compositions include the full, intact antibody and size variants thereof that not include two antibody heavy chains and to antibody light chains. Thus, a M281 pharmaceutical composition can include: an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:2 and a light chain comprising the amino acid sequence of SEQ ID NO:1, wherein the composition comprises a major protein component having a molecular weight of 140,000-145,000 Da and a minor protein component of molecular weight 118,000-120,000 Da.

An ion source includes a vaporizer, an arc chamber, and a heat shield. The vaporizer includes a crucible containing an aluminum-containing material and a heater that heats the crucible. The crucible has a gas inlet and a vapor outlet. The arc chamber generates a plasma inside of the arc chamber. The vapor outlet outputs vapor into the arc chamber through a wall of the arc chamber, and the heat shield is provided between the vaporizer and the wall of the arc chamber.

The utility model discloses a combined rectangular tube structure which comprises a bottom support, a first inserting hole is formed in one end of the bottom support, a second inserting hole communicated with the first inserting hole is formed in the other end of the bottom support, an atomizer connector is inserted into the first inserting hole in a matched mode, and a central tube connector is inserted into the second inserting hole in a matched mode. The end, away from the atomizer connector, of the bottom support is detachably connected with a rectangular tube base, the end, close to the atomizer connector, of the rectangular tube base is provided with a third insertion hole matched with the central tube connector in an inserted mode, and a fourth insertion hole communicated with the third insertion hole is formed in the rectangular tube base. A fifth inserting hole communicated with the fourth inserting hole is formed in the end, away from the atomizer connector, of the rectangular tube base, a rectangular tube inner tube is inserted and matched with the end, away from the atomizer connector, of the central tube connector, and a rectangular tube middle tube arranged on the outer side of the rectangular tube inner tube in a sleeving mode is inserted and matched with the interior of the fourth inserting hole; a rectangular pipe outer pipe arranged on the outer side of the rectangular pipe middle pipe in a sleeving mode is inserted into the fifth inserting hole in a matched mode. The use cost of the instrument is saved.

A method of pretreatment of a sample containing a cell for mass spectrometry, including contacting the cell with a first acidic solution containing an organic acid; and extracting a cytoplasmic component of the cell by heating the cell in contact with the first acidic solution.

The invention discloses an ion trap mass spectrometry device and method capable of switching internal and external ion sources, and the device comprises an ion source cavity, the exterior of the ion source cavity is provided with a heating module, the side wall of the ion source cavity is provided with a sample introduction hole, and the sample introduction hole is internally provided with a chromatographic column I; the electron beam generation system is arranged at the front side position of the ion source cavity; the insulation connecting piece is communicated with the ion source cavity, and a lens I, a lens II and a lens III are sequentially arranged in the insulation connecting piece in the sample injection direction; a signal acquisition system; wherein a chromatographic column II is arranged on the ion trap. The two ionization modes inside and outside the trap are integrated, and different detection requirements can be flexibly met by switching the sample introduction path of the chromatographic column and regulating and controlling the voltage parameters of the lens I, the lens II and the lens III.

To provide an impedance matching circuit using an insulated air core transformer, and a mass spectrometer including the same, to increase the measurement accuracy.SOLUTION: A mass spectrometer includes: a sample introduction part; an ionization part connected to the sample introduction part and including a plasma coil that ionizes a sample introduced from the sample introduction part; an RF power supply part that is electrically connected to the ionization part and that supplies RF power to the ionization part; an ion lens part that includes an extraction lens adjacent to the ionization part, and a guide lens configured to guide an ion beam extracted from the extraction lens; and a detection part that detects the ion beam. The RF power supply part includes an impedance matching circuit that controls a voltage due to an inductance component of the plasma coil.SELECTED DRAWING: Figure 1

Embodiments pertain to a laser arrangement configured for enhancement of an ionizaon process of molecular oxygen by causing a two-photon-based transion followed by a (e.g., disnct) third photon- based transion for ionizing the molecular oxygen. In some examples, the laser arrangement comprises at least one laser source configured to output towards at least one oxygen molecule laser light having mulple wavelengths (WL), as follows: outpu[ng at least one electromagnec (EM) radiaon within a first WL range adapted to cause two-photon-based excitaon of the molecular oxygen into a (e.g., disnct) excited state; and outpu[ng at least one addional EM radiaon that is within a second WL range adapted to cause ionizaon of the molecular oxygen from the (e.g., disnct) excited state.

A method for a structural analysis of a sample molecule using a mass spectrometer includes: a process for obtaining a standard analysis condition for each of setting items for performing a molecular-related ion measurement, where the setting items include an ion amount setting item, a mass-to-charge-ratio range setting item, and a signal intensity setting item; a process for performing a product ion measurement under an altered analysis condition, to acquire mass spectrum data of the product ion measurement, where the altered analysis condition is prepared by changing at least one of analysis conditions of the ion amount setting item, the mass-to-charge-ratio range setting item and the signal intensity setting item in the standard analysis condition; a process for extracting peaks corresponding to the fragment ions; and a process for determining at least a portion of the structure of the sample molecule based on mass information of the extracted peaks.