92results about "Ion sources/guns" patented technology

An embodiment disclosed herein includes a process tool for measuring neutral radical concentration. In one embodiment, the process tool comprises a process chamber and a Neutral Radical Mass Spectroscopy (NRMS) analyzer fluidically coupled to the process chamber. In one embodiment, the NRMS analyzer comprises a first chamber fluidically coupled to the process chamber, the first chamber comprising a modulator, and a second chamber fluidically coupled to the first chamber, the second chamber being a residual gas analyzer or mass spectrometer. In one embodiment, an unobstructed line of sight passes from the process chamber to the second chamber.

Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.

The present invention relates to an apparatus for analyzing peak data generated from a mass signal acquired by a mass spectrometry system, comprising: a streaming device including a first network interface and configured to (a) generate peak data from the acquired mass signal or receive peak data generated externally from the acquired mass signal, (b) group the peak data into a plurality of independently processable data packets, the data packets relating to a processing task, and (c) distribute the data packets as a task-specific stream onto a network via the first network interface; and at least one analysis device including a second network interface and configured to (a) retrieve data packets of a task-specific stream from the network via the second network interface, (b) perform a processing task on the retrieved data packets to generate result data, (c) encapsulate the result data in a result data packet, and (d) distribute the result data packet onto the network via the first network interface.

The invention discloses a plasma electrospray fusion ionization source and mass spectrum combined system and a detection method. The plasma electrospray fusion ionization source and mass spectrum combined system comprises a coaxially nested electrospray needle, a sample injector, an ultrahigh voltage generator, a grounded metal grid mesh, a mass spectrometer and a detector thereof. A grounded metal grid is installed between a spray needle and a mass spectrum inlet, voltage is applied to the spray needle, carrier gas is excited to generate plasmas, the macroscopic plasmas at the front end of the spray needle are fused with electrospray, and the plasmas and micro-droplets at the tip of the spray needle are fused. According to the unique ionization source constructed by the plasma-micro-droplet fusion system, on one hand, the ionization efficiency is improved, mass spectrum signals are enhanced, the application range of analytes is widened, excellent sensitivity to high-polarity compounds is kept, and effective ionization and detection of low-polarity compounds are achieved; on the other hand, higher energy and active species are provided for the micro-droplet reaction, the energy barrier required by traditional synthesis is broken, and efficient spontaneous product generation of the micro-droplet chemical reaction is achieved.

An interface and a sample analysis method using the same are disclosed herein. In some embodiments, an interface is between a liquid chromatography (LC), an ionization device, and a mass spectrometer (MS), wherein a sample containing a target eluted from the liquid chromatography is ionized by the ionization device and the sample is introduced into the mass spectrometer, wherein the interface includes a droplet sprayer, an evaporator having a heatable block, and an introduction tube, wherein the heatable block has one or more openings, the droplet sprayer for converting the sample into sample droplets and for spraying the sample droplets, the evaporator for evaporating a solvent in the sample droplets to generate a gaseous target by passing the droplets through the one or more openings, the introduction tube for receiving the gaseous target and for introducing an ionized gaseous target into the mass spectrometer.

A heating device and a mass spectrometry device of a nanoelectrospray source, the heating device comprising: a support body and a heating body arranged on the support body, the heating body being configured to apply a heating effect to an ion transmission path and being provided with an ion transmission channel for the passage of ions or charged droplets; an ion inlet of the ion transmission channel corresponding to an ion outlet of the nanoelectrospray source, and an ion outlet of the ion transmission channel corresponding to an ion inlet of the mass spectrometer. The heating device can significantly improve the atomization and desolvation capability of the nanoelectrospray source, improve the signal response and repeatability, reduce the ion cluster background noise formed by solvent molecules, improve the sensitivity, and avoid the spray stop and signal loss caused by the heat-sensitive drying of the nanoelectrospray ion source at the end of the spray needle.

A positioning device for an analytical instrument (e.g., an atom probe microscope or other nanoscale microscope) includes a primary carriage translatable relative to a vacuum chamber wall, and a secondary carriage connected to the primary carriage by a plurality of spaced actuators that allow the secondary carriage to translate and / or tilt relative to the primary carriage. An arm then extends from the secondary carriage through the vacuum chamber wall and connects to the instrument. The instrument may be rapidly extended or retracted within the vacuum chamber via its connection to the primary carriage, and may be more finely translated and / or tilted via its connection to the secondary carriage. A damping arrangement isolates the instrument from vibrations.

One aspect of a method for manufacturing a quadrupole mass filter according to the present invention is a method for manufacturing a quadrupole mass filter including four rod electrodes, comprising a first step (S1, S2) of forming a hyperbolic surface by cutting at least a part of a side surface or a peripheral surface of each of four rod-shaped members over a longitudinal direction, each of the four rod-shaped members having a length in a range of 80 mm or more and 120 mm or less, and a second step (S3) of positioning and fixing the four rod-shaped members, on which the hyperbolic surfaces are respectively formed, as rod electrodes using a holding member, such that the four rod electrodes surround a central axis and the hyperbolic surface of each rod electrode faces the central axis.

This invention discloses a miniaturized portable mass spectrometer based on a vacuum ultraviolet photoionization source and its analytical method, relating to the field of mass spectrometry analysis technology. The mass spectrometer includes: a sample introduction and pre-screening module, consisting of a sample introduction system and an intelligent sample pre-screening unit. The sample introduction system enables gas-liquid sample switching. The pre-screening unit collects data through physical and chemical characteristic detection subunits, and outputs target compound type and parameter adjustment instructions after processing by a data analysis subunit. This invention, through the intelligent sample pre-screening unit in the sample introduction and pre-screening module, utilizes physical and chemical characteristic detection subunits to quickly acquire physicochemical characteristic data such as the color spectrum, volatile components, and pH value of the sample. The compound type recognition model built into the data analysis subunit can automatically compare with the sample characteristic database, quickly identify the target compound type, and generate ionization source parameter adjustment instructions, greatly simplifying the operation process and reducing detection time.

To provide software for microfluidic systems interfacing with mass spectrometry.SOLUTION: Methods, devices, and systems for improving the quality of electrospray ionization mass spectrometer (ESI-MS) data are described, as are methods, devices, and systems for achieving improved correlation between chemical separation data and mass spectrometry data. Some embodiments described herein relate to innovative software and systems for analyzing data from and directing the operation of capillary- and microfluidic-based separation systems integrated with mass spectrometric detection. In some embodiments, analytes are imaged during separation in capillaries or on microfluidic devices, and the molecular weight or mass / charge ratio is measured in a mass spectrometer after the separation.SELECTED DRAWING: Figure 18

In an embodiment, a laser ablation system can include a laser ablation cell and at least a pair of particle-collection-to-transport-tubing interfaces. The laser ablation cell can be configured for ablating a sample or another material, and the laser ablation cell can include a laser unit. The at least a pair of particle-collection-to-transport-tubing interfaces can be configured to gather an ablated sample and direct the ablated sample to an analysis unit. A selected particle-collection-to-transport-tubing interface can be received by the laser ablation cell directly above the laser unit. The at least a pair of particle-collection-to-transport-tubing interfaces can be configured to be interchangeable with one another.

Systems and methods are described for controlling flow of a purge gas introduced to an ablation cell between samples to remove atmospheric gas. A system embodiment includes, but is not limited to, a spray chamber including a spray chamber body, a transfer gas inlet configured to receive gas from a laser ablation sample cell, a first outlet line configured to transfer gas from the spray chamber to an inductively-coupled plasma torch, and a second outlet line coupled to the spray chamber body, the second gas outlet having a larger internal cross-sectional area than an internal cross-sectional area of the first outlet line; and a valve fluidically coupled to the second outlet line, the valve configured to transition between at least an open configuration configured to permit transfer gas through the second outlet line and a closed configuration configured to prevent transfer of gas through the second outlet line.

The application discloses an ion source device for desorption of americium 241, and relates to the technical field of ion sources.The ion source device mainly comprises americium 241, a clamping device for the americium 241, an R-axis rotating platform and a sample stage.The americium 241 is installed on the clamping device for the americium 241, and the clamping device is installed on the R-axis rotating platform.A glass slide coated with a sample is installed on the sample stage, and the sample stage and the R-axis rotating platform are installed on two XYZ-axis displacement platforms, respectively, and the two XYZ-axis displacement platforms are adjusted to move in the X, Y and Z directions, respectively.The alpha particles generated by the americium 241 decay generate a series of plasmas in the air and are injected into the surface of the sample, so that the molecules on the surface of the sample are ionized and desorbed, and the ions enter a mass spectrometer through a sample inlet for detection.The relative positions of the americium 241, the sample stage and the sample inlet are adjusted, so that the mass spectrometer obtains the best ion signal, and the operation is safe and simple, and the common molecules can be rapidly detected.

This allows for more precise focusing of the post-ionization laser beam and maintains the ion source in optimal or better condition. [Solution] The ion source 100 includes a substrate 1, a first laser generator 2, a second laser generator 3, a detector 4, and a drive mechanism 5. The substrate 1 supports the sample, and the first laser generator 2 emits a first laser beam 2a onto the substrate 1, desorbing and ionizing the sample to form a particle plume. The focusing position of the second laser generator 3 is located away from the sample and the substrate 1, and is separated from the substrate 1 by a predetermined distance, ionizing the particle plume to obtain signal ions. The detector 4 detects the signal intensity of the signal ions, and the drive mechanism 5 moves the focusing position of the second laser generator 3. The endpoint of the focusing position is determined based on a comparison between the respective signal intensities detected by the detector 4 during the movement of the focusing position.

The gas analyzer (1) comprises a sample chamber (40) into which a sample gas (9) to be measured flows, a plasma generation circuit (10) that generates plasma (8) in the sample chamber (40), and an analyzer 30 that analyzes the sample gas via the plasma (8) generated in the sample chamber. The plasma generation circuit (10) includes a plasma induction circuit (13) and an RF power supply circuit (11) configured to supply RF power to the plasma induction circuit. The plasma induction circuit is directly incorporated as at least part of the resonant components of the RF power supply circuit.

To allow a proper delay extracting parameter to be easily decided when analyzing a sample which generates a peak in a wide m / z range by a time-of-flight mass spectrometer.SOLUTION: A mass spectrometry system comprises: a time-of-flight mass spectrometer 10 which performs extraction of ions by means of the delay extraction method; and a control computer. The control computer comprises: a model sample analysis data storage unit 61 which stores results of plural times of mass spectrometry performed by changing the delay time in the delay extraction method to the model sample; an input reception unit 36 which receives an input of a target m / z range in an inspection object sample; an average value calculation unit 33 which calculates an average value of the mass resolution in the target m / z range for each of the results of the plural times of mass spectrometry; and a parameter decision unit 34 which decides the delay time corresponding to the mass spectrometry result whose average value becomes highest as a value optimum for analysis of the inspection object sample.SELECTED DRAWING: Figure 1

An ionizer disposed in an ionization chamber separated from an analysis chamber by a partition provided with an ion introduction port, the ionizer including: an electrospray ionization probe 111 configured to charge and nebulize a liquid sample as charged droplets, the electrospray ionization probe being disposed such that a nebulization axis is orthogonal to a central axis of the ion introduction port; and a heated gas supply mechanism configured to blow a heated gas to a position between a tip of the electrospray ionization probe and an intersection point X of the nebulization axis and the central axis, where the position is separated from the tip by a predetermined distance or more.

An emission stand (201) for an optical emission spectrometer, comprising a discharge box (210) and at least one auxiliary gas conduit (209a, 209b) for supplying an auxiliary gas flow into the discharge box (210), the at least one auxiliary gas conduit (209a, 209b) being configured to supply an auxiliary gas flow (214) into the discharge box (210) for a period of time after a spark action, but not during a spark action during which an analysis of a sample is performed. The auxiliary gas flow (214) into the discharge box (210) improves dust flushing from the discharge box (210) after the spark action.

The present disclosure relates to a method for analyzing and predicting deuterium substitution rates of a deuterium-substituted sample using a mass spectrometry spectrum of the deuterium-substituted sample.

SUMMARY OF THE DISCLOSURE Provided are improved systems and methods for monitoring radical particle concentrations using mass spectrometry. A monitoring system detects and measures the quantity of radical particles in a gas. A test chamber is coupled to a flow channel that transmits a gas. The test chamber defines an aperture connecting the test chamber and the flow channel, the aperture allowing a subset of the gas to enter the test chamber from the flow channel. An ionizer is positioned within the test chamber and generates radical ions from the radical particles of the subset of the gas. A mass spectrometer measures the quantity of radical ions, thereby providing a measurement of the radical particles in the gas.

This application relates to the field of ion analysis, in particular to an ion source, a mass spectrometer and a method for generating ions. The ion source includes a substrate, a first laser generator, a second laser generator, a detector, and an actuating device. The substrate carries a sample. The first laser generator projects a first laser beam to the substrate, thereby desorbing and ionizing the sample to obtain a particle plume. The second laser generator ionizes the particle plume to obtain signal ions, focus of the second laser generator being located on a side of the sample away from the substrate and disposed a predetermined distance away from the substrate. The detector detects a signal intensity of the signal ions. The actuating device moves the focus of the second laser generator. A destination where the focus is moved to is determined by comparison between different signal intensities detected by the detector during a movement of the focus. The ion source can accurately focus a post-ionization laser beam to keep the ion source working in a better state.

The application belongs to the technical field of mass spectrometry instruments, and particularly relates to a mass spectrometry ion source device and a mass spectrometer comprising the same. The mass spectrometry ion source device comprises: a sample inlet device, a plasma ion source and a gas curtain, the sample inlet device is communicated with a structure for generating plasma in the interior of the plasma ion source through a first sample inlet channel, the sample inlet device is connected with the gas curtain through a second sample inlet channel, a high-temperature plasma flame outlet is arranged at the tail of the plasma ion source, and the direction in which the high-temperature plasma flame outlet sprays high-temperature plasma flame and the direction in which the gas curtain sprays gas are arranged to intersect each other. The application further provides a mass spectrometer with the above mass spectrometry ion source device. The mass spectrometry ion source device can simultaneously perform elementization high-energy ionization and organic matter ionization on a sample, so as to achieve the purpose of simultaneously detecting inorganic elements and organic elements in the sample by using mass spectrometry, and has a good application prospect.

An ion molecule reactor for generating analyte ions from analytes comprises:a) a reaction volume in which reagent ions can interact with the analytes in order to form analyte ions;b) at least one analyte inlet for introducing the analytes along an inlet path into the reaction volume whereby, preferably, the inlet path runs essentially along at least a first section of the predefined transit path in the reaction volume;c) at least one reagent ion source and / or at least one reagent ion inlet for providing reagent ions into the reaction volume;d) optionally, at least one ion guide comprising an electrode arrangement which is configured for producing an alternating electrical, magnetic and / or electromagnetic field, that allows for guiding the reagent ions and / or the analyte ions at least along a section of the predefined transit path, preferably along the whole transit path, through the reaction volume.

The present invention provides a storage box for preventing damage from occurring during transport, storage, or retrieval of capillaries to be used in a mass spectrometer. This storage box has: a base (101) provided with a groove-like storage part (110) in which to store a capillary (90); and a lid (102) that covers the base. The storage part comprises: a first region (110b) of a first groove width to secure a capillary holding part when the capillary is stored; and a second region (110a) having a groove width narrower than the first groove width, where a capillary body part is to be stored when the capillary is stored. The second region comprises a shallow groove region (213) where at least the other end of the capillary body part is to be stored when the capillary is stored. The region between the shallow groove region and the first region is made to be deeper than the shallow groove region.

In one embodiment, a method for imaging a biological specimen is disclosed, which includes defining a plurality of reference points across the surface of the biological specimen; directing ablation radiation to the biological specimen at a first plurality of specimen locations corresponding to a first subset of the defined reference points, thereby ablating at least a portion of the specimen at each of the locations, thereby generating a gas-phase sample from each of the specimen locations; ionizing each of the gas-phase samples to generate ions corresponding to the gas-phase sample; acquiring one or more mass signals corresponding to the ions associated with each of the ablated portions; and identifying at least one region of interest based on the analysis of the mass signals. An image of the identified region of interest can be acquired using image mass cytometry.

To provide a leak detector which is configured to detect leakage by introducing hydrogen gas leaking form a test piece to an analysis tube and to provide sufficient measurement accuracy in a short time by facilitating stabilization of background and significantly reducing the time required for background recovery.SOLUTION: An analysis tube 100 provided herein comprises an ion source portion 1 for ionizing hydrogen gas introduced thereto to generate hydrogen ions, an ion collector portion 2 for detecting the amount of hydrogen ion current, and re-inflow suppression structures 71, 72, 73 for preventing hydrogen gas generated by the ions by being uncharged by the ion collector portion 2 from reflowing into the ion source portion 1.SELECTED DRAWING: Figure 5