958results about "Ion sources/guns" patented technology

The invention relates to the technical field of instruments and meters, in particular to an inductively coupled plasma mass spectrometer system for intelligent data processing and report generation. Comprising a sample introduction unit, a plasma excitation and ionization unit, a mass analyzer and detection unit, a vacuum system unit and an intelligent data processing and report generation unit. Efficient ionization is achieved through a bipolar radio frequency switching and AI optimized reaction gas plasma source, the AI optimization module monitors in real time and dynamically adjusts parameters so that the ionization efficiency can be stabilized at 92% + / -2%, and meanwhile a reaction gas control system can optimize plasma conditions to suppress interference ions. And the mass analyzer and the detection unit realize high-precision ion separation by utilizing AI interference correction and a QMS-TOF double analyzer mode, and an interference elimination module can automatically eliminate polyatomic ion interference, so that the ionization efficiency, the analysis precision and the accuracy are improved, the interference is effectively inhibited, and the analysis capability of the system on a complex sample is enhanced.

A hybrid inductively coupled plasma mass spectrometer (ICP-MS) system is disclosed for simultaneous elemental and molecular analysis in positive and negative polarities. It includes an ICP torch that generates plasma with a buffer gas, producing both positively and negatively charged ions from a sample. Positioned between the sampler and skimmer, an insert with a defined geometry forms a reaction chamber. Various embodiments feature multiple apertures for pressure control, a rotatable disk for aperture regulation, a slider gate for pressure adjustment, a circular gate with adjustable radial apertures, and an inlet for introducing gases, reagents, dopants, or analytes. These components enable precise pressure modulation, optimizing performance for dual-polarity mass spectrometry. The system enhances analytical flexibility by facilitating controlled ion reactions, improving sensitivity and specificity for both elemental and molecular applications. This innovation expands ICP-MS functionality, supporting diverse scientific and industrial applications requiring high-precision mass analysis.

The present invention discloses a method for analyzing sources of Cd / Pb combined polluted farmland soil using bimetallic isotopes (Cd—Pb), comprising the following steps: collecting respectively a soil sample and risk source samples through a sample collection device; determining respectively Cd isotope ratio and Pb isotope ratio of the soil sample and the risk source samples; plotting by using the Cd isotope ratio and the Pb isotope ratio of the soil sample and the risk source samples as coordinates, to obtain a projection plot of the isotope ratios; recognizing a pollution end-member polluting farmland soil through the projection plot of the isotope ratios to obtain a recognition result for the pollution end-member, and then confirming the pollution end-member; and calculating a relative contribution rate of the pollution end-member, to obtain an analysis result for the source of isotopes. The present invention uses the two metal isotopes of Cd—Pb to mutually restrict and confirm each other to solve the problem of poor analytical accuracy caused by similar or overlapping isotope values of samples and isotope fractionation, and realizes accurate recognition and quantitative analysis for the source of heavy metals Cd / Pb pollution of farmland soil.

The invention discloses a sampling device for ICP-MS (Inductively Coupled Plasma Mass Spectrometry) in the technical field of instrumental analysis. The sampling device comprises a liquid inlet mechanism and an atomization mechanism, the liquid inlet mechanism is used for inputting a liquid sample into the atomization mechanism, the atomization mechanism comprises a concentric atomizer and an atomization chamber, the concentric atomizer is communicated with the atomization chamber, and the atomization chamber is communicated with a waste liquid barrel and an ICP torch pipe; a self-cleaning mechanism is arranged on a communication path of the concentric atomizer and the atomizing chamber, the self-cleaning mechanism comprises a movable cylinder, the movable cylinder is rotationally connected into a nozzle of the concentric atomizer, contact electrodes are symmetrically arranged in the movable cylinder, and when the movable cylinder is blocked, the contact electrodes form a path; the contact electrode is electrically connected with a torsion mechanism and a reverse blowing mechanism, the torsion mechanism is used for twisting the movable cylinder when the contact electrode forms a path, and the reverse blowing mechanism is used for intercepting carrier gas input into the concentric atomizer and reversely blowing the carrier gas out of a nozzle of the concentric atomizer. According to the invention, self-cleaning can be carried out when blockage occurs in the sample introduction process, and sample analysis interruption caused by blockage is reduced.

The invention relates to the technical field of vacuum equipment, and discloses an ion lens assembly, an ion source, a mass spectrometer and a mass spectrometry system. The ion lens assembly includes a deflection lens assembly and a return lens assembly. The deflection lens assembly is used for focusing an ion beam in the incident particle beam and enabling the ion beam to deflect towards a first direction. And the axis-returning lens assembly is used for receiving the ion beam from the deflection lens assembly, and the axis-returning lens assembly is used for focusing the received ion beam and enabling the ion beam to deflect towards a second direction.

A method and corresponding devices to reduce the presence of unwanted ions within the pseudo-potential well of the RF fields for inductively coupled plasma mass spectrometry is disclosed. This method reduces space-charge effects and leaves more room available for the ions of interest and, hence, leads to increased transmission of the desired ions into the mass analyzer. In the present invention, the space charge is reduced by adding a low-band resolving DC potential, or a fast sweeping resolving DC potential with a notch, or a fast constant resolving DC potential with a notch, or by adding auxiliary quadrupolar or dipolar RF potential to the quadrupole ion guide, such that all the unwanted ions will be outside the stable region and therefore ejected. This reduces the charge density in the ion beam and ameliorate space charge effects.

The present invention relates to the field of analytical chemistry, and discloses a mass spectrum ionization element for macrolide antibiotic detection and a preparation method thereof, the mass spectrum ionization element comprises: a conductive substrate made of stainless steel; the adsorption layer is attached to at least part of the surface of the substrate, the adsorption layer is formed by a boric acid functionalized covalent organic framework, and the boric acid functionalized covalent organic framework is of a polycyclic structure composed of repeated units shown in the formula I in the specification. The mass spectrum ionization element is uniform in coating, high in selectivity on macrolide enriched antibiotics in a complex matrix and high in enrichment capacity, an eluent of the mass spectrum ionization element can be used for detection based on a liquid chromatography method and can also serve as a mass spectrum ion source solid substrate, mass spectrum detection is conducted through electrospray ionization, the detection steps are simple, and the mass spectrum ionization element is suitable for mass spectrum detection. And the detected background noise is low.

The invention provides a reactor and a dual-light-source mass spectrum device for in-situ detection of gas-phase species in a catalytic reaction. The reactor comprises a control part, a first tube body and a second tube body, the control part comprises a first shell and a switching piece; the first shell is provided with a first channel and a second channel which are arranged in the first direction. The switching piece is arranged between the first channel and the second channel; the first pipe body extends in the first direction and is located on the side, away from the second channel, of the switching piece. The first pipe body is communicated with the first channel; the second pipe body extends in the first direction and is partially located in the second channel. The second pipe body is connected with the first shell and can move in the first direction relative to the first shell. The switching piece moves relative to the first shell to control connection and disconnection of the first channel and the second channel. When the first channel communicates with the second channel, the second pipe body is allowed to partially extend into the second pipe body, and when the first channel is isolated from the second channel, the second pipe body is located on the side, away from the first channel, of the switching piece. The application of the reactor realizes material replacement on the premise of not breaking vacuum.

A system and method for determining a net source rock thickness is disclosed. The method includes obtaining at least one well log, a first and second plurality of core samples from a wellbore, and for each of the first plurality determining a relative abundance of inorganic materials, and for each of the second plurality a set of organic material data. The method further includes determining a validated total organic content and a measured source rock thickness based on the organic material data and relative abundance of inorganic materials and determining a data and a prediction portion of the wellbore, based on the second plurality sample locations. The method still further includes determining a cut-off value for each well log, predicting a source rock thickness from the cut-off values and the net source rock thickness from a sum of the predicted and the measured source rock thicknesses.

This disclosure pertains to compositions comprising an anti-FcRn antibody, M281. The compositions include the full, intact antibody and size variants thereof that not include two antibody heavy chains and to antibody light chains. Thus, a M281 pharmaceutical composition can include: an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:2 and a light chain comprising the amino acid sequence of SEQ ID NO:1, wherein the composition comprises a major protein component having a molecular weight of 140,000-145,000 Da and a minor protein component of molecular weight 118,000-120,000 Da.

A method of pretreatment of a sample containing a cell for mass spectrometry, including contacting the cell with a first acidic solution containing an organic acid; and extracting a cytoplasmic component of the cell by heating the cell in contact with the first acidic solution.

The invention discloses an ion trap mass spectrometry device and method capable of switching internal and external ion sources, and the device comprises an ion source cavity, the exterior of the ion source cavity is provided with a heating module, the side wall of the ion source cavity is provided with a sample introduction hole, and the sample introduction hole is internally provided with a chromatographic column I; the electron beam generation system is arranged at the front side position of the ion source cavity; the insulation connecting piece is communicated with the ion source cavity, and a lens I, a lens II and a lens III are sequentially arranged in the insulation connecting piece in the sample injection direction; a signal acquisition system; wherein a chromatographic column II is arranged on the ion trap. The two ionization modes inside and outside the trap are integrated, and different detection requirements can be flexibly met by switching the sample introduction path of the chromatographic column and regulating and controlling the voltage parameters of the lens I, the lens II and the lens III.

Embodiments pertain to a laser arrangement configured for enhancement of an ionizaon process of molecular oxygen by causing a two-photon-based transion followed by a (e.g., disnct) third photon- based transion for ionizing the molecular oxygen. In some examples, the laser arrangement comprises at least one laser source configured to output towards at least one oxygen molecule laser light having mulple wavelengths (WL), as follows: outpu[ng at least one electromagnec (EM) radiaon within a first WL range adapted to cause two-photon-based excitaon of the molecular oxygen into a (e.g., disnct) excited state; and outpu[ng at least one addional EM radiaon that is within a second WL range adapted to cause ionizaon of the molecular oxygen from the (e.g., disnct) excited state.

A method for a structural analysis of a sample molecule using a mass spectrometer includes: a process for obtaining a standard analysis condition for each of setting items for performing a molecular-related ion measurement, where the setting items include an ion amount setting item, a mass-to-charge-ratio range setting item, and a signal intensity setting item; a process for performing a product ion measurement under an altered analysis condition, to acquire mass spectrum data of the product ion measurement, where the altered analysis condition is prepared by changing at least one of analysis conditions of the ion amount setting item, the mass-to-charge-ratio range setting item and the signal intensity setting item in the standard analysis condition; a process for extracting peaks corresponding to the fragment ions; and a process for determining at least a portion of the structure of the sample molecule based on mass information of the extracted peaks.

An inlet for an analytical instrument comprises a transfer tube having an upstream end and a downstream end and a deposition region arranged at or adjacent to the upstream end of the transfer tube. The transfer tube is configured to transfer ions together with a gas flow from the upstream end to the downstream end. The transfer tube and the deposition region are configured such that the gas flow experiences at least one turn in the deposition region, whereupon relatively large particles entrained in the gas flow are deposited in the deposition region. The at least one turn in the gas flow is created by: a change in cross-sectional area of the gas flow in the deposition region, a change in diameter of the gas flow in the deposition region, and / or a change in cross-sectional shape of the gas flow in the deposition region.

Determination of sensitive and accurate feature values from a matrix-assisted laser desorption / ionization (MALDI) spectrum of a sample is provided. A peak shape function of the mass spectrometer is read. A fine structure component is determined for a first range of the mass spectrum by estimating and subtracting a first background from the mass spectrum. A bump structure is determined for the first range by estimating a second background, which is stiffer than the first background, and subtracting it from the first background. A convolution of the fine structure component is computed for the first range of the mass spectrum with the peak shape function. A first plurality of peaks in the first range is determined from the convolution. A feature value indicative of an abundance associated with each of the first plurality of peaks is determined by combining the first plurality of peaks with the bump structure.

A method of adjusting a position of a tip of an electrode relative to an end of a nebulizer nozzle of a mass spectrometry device includes providing a conduit and the electrode connected to the conduit at a first end of the conduit. The electrode tip is disposed at a first position relative to the nebulizer nozzle end. The pressure gauge is connected to a second end of the conduit. A gas ejection is initiated from the nozzle with the electrode tip at the first position. During the gas ejection, the position of the electrode tip is adjusted from the first position towards a second position relative to the nozzle end. Adjusting the position from the first position towards the second position is terminated when the pressure gauge displays a pressure condition. Once adjusting is terminated, the electrode tip is at the second position.

Methods and systems for multi-beam, parallel-beam, deterministic, or super mass spectrometry that include an ion source that produces ions, and two or more ion trapping devices or mass spectrometers, each having an independent sampling inlet. The two or more ion trapping devices or mass spectrometers receive the ions from the ion source via the sampling inlet of each of the ion trapping devices or mass spectrometers such that each sampling inlet provides an ion beam to each corresponding ion trapping device or mass spectrometer.

Systems and approaches for semiconductor metrology and surface analysis using Secondary Ion Mass Spectrometry (SIMS) are disclosed. In an example, a secondary ion mass spectrometry (SIMS) system includes a sample stage. A primary ion beam is directed to the sample stage. An extraction lens is directed at the sample stage. The extraction lens is configured to provide a low extraction field for secondary ions emitted from a sample on the sample stage. A magnetic sector spectrograph is coupled to the extraction lens along an optical path of the SIMS system. The magnetic sector spectrograph includes an electrostatic analyzer (ESA) coupled to a magnetic sector analyzer (MSA).

An apparatus for analyzing peak data generated from mass signals acquired by a mass spectrometric system comprises: a streaming device that comprises a first network interface and is configured to generate peak data from the mass signals or receive peak data generated externally from the mass signals, group the peak data into independently-processable data packets related to a processing task, and distribute the data packets in a task-specific stream via the first network interface onto a network; and at least one analyzing device that comprises a second network interface and is configured to retrieve a data packet of the task-specific stream via the second network interface from the network, perform the processing task on the retrieved data packet to produce result data, package the result data in a result data packet, and distribute the result data packet via the first network interface onto the network.

The invention relates to the technical field of analysis instrument ionization sources, in particular to a VUV lamp ionization source device with efficient heat dissipation capacity. The device comprises a VUV lamp, a heat dissipation unit, a VUV lamp driving electrode, a driving circuit and an ion guide focusing unit. The heat dissipation unit carries out cooperative heat dissipation on the VUV lamp and the pulse transformer through a fan, and the problems of signal attenuation and device aging caused by temperature rise are solved. The driving electrode adopts a pairwise pairing structure of upper and lower and left and right electrode pairs to form an inclined electric field to prevent ions from bombarding the lamp wall and the light window; the drive circuit is a half-bridge or full-bridge topology, can adjust the pulse frequency and the power supply voltage, and achieves the switching between a high-voltage low-frequency mode and a low-voltage high-frequency mode. The ion guide focusing unit efficiently leads out and separates ions through cooperation of a conical focusing electric field and a conductive film forward electric field. Through four-dimensional innovation of heat dissipation, electrodes, driving and transmission, the stability, the service life and the detection sensitivity of the device are improved, and the device is suitable for analytical instruments such as ion mobility spectrometry and mass spectrometry.

A sampling interface 100 for use in mass spectroscopy apparatus, comprising: an inlet 110 for receiving a quantity of particles from an ion source; a skimmer 115 having an aperture arranged downstream

An embodiment disclosed herein includes a process tool for measuring neutral radical concentration. In one embodiment, the process tool comprises a process chamber and a Neutral Radical Mass Spectroscopy (NRMS) analyzer fluidically coupled to the process chamber. In one embodiment, the NRMS analyzer comprises a first chamber fluidically coupled to the process chamber, the first chamber comprising a modulator, and a second chamber fluidically coupled to the first chamber, the second chamber being a residual gas analyzer or mass spectrometer. In one embodiment, an unobstructed line of sight passes from the process chamber to the second chamber.

The invention relates to the technical field of mass spectrometers, and discloses an analytical instrument based on glow discharge and quadrupole mass spectrometry combination, which comprises an ion source, an ion transmission system and an ion separator, wherein the ion source is a glow discharge ion source; the ion separator is a quadrupole rod mass analyzer, and the quadrupole rod mass analyzer comprises four electrodes which are arranged in parallel. Compared with an existing analytical instrument, the glow discharge ion source can directly analyze a solid sample without being pretreated into a solution, and compared with an inductively coupled plasma source, the glow discharge ion source is small in matrix effect and especially suitable for high-salt and high-carbon samples; the quadrupole rod mass analyzer is simple in structure, small in size, low in cost, especially suitable for commercialized popularization and high in scanning speed.

A coupling tube made of a stretchable elastomeric material. The "stretchy" coupling tubing allows for improved reliability / repeatability of coupling performance. For example, the stretch provided can take up tolerances between positions of imager and reader instruments. In one example, the stretch can take up tolerances between positions of the junction between the rigid portion of tubing inside the IMC unit and the injector to an ionization source. The coupling tube may also be provided with a reduced inner diameter (ID) as compared to standard coupling components. A taper in the inner diameter (ID) can occur before the flow enters the stretchable coupling tube. Barbed ends may also be provided for securing the coupling tube into place.

The invention relates to a spray head for electrospray ionization (ESI). The invention also relates to a method for producing a spray head according to the invention and to the use of a spray head according to the invention for electrospray ionization (ESI). The invention also relates to a chromatography column comprising a spray head according to the invention and to a device for carrying out electrospray ionization (ESI) comprising a spray head according to the invention or comprising a chromatography column according to the invention.

The invention discloses an ionization device. Electrospray is an ionization mode, and after the electrospray is combined with a mass spectrometer or an ion mobility instrument, atoms and molecules can be analyzed or some microorganisms or cells can be directly analyzed. Based on the process that liquid fluid is atomized and expanded firstly and then gaseous fluid is compressed before entering an instrument in the electrospray process, a geometric structure cavity matched with the liquid fluid in shape is designed and used for spraying. By means of the mode that the shape is matched with the introduction process of the fluid, spray moves forwards as much as possible in a laminar flow mode, so that more stable spray fluid is obtained, and ions can be better introduced into an instrument for analysis.

Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.

The application discloses a kind of based on plasma atomization gas auxiliary electric spray ionization method, comprising the following steps: a) sample solution is introduced into electric spray needle;B) open plasma initiation device, make plasma initiation device discharge and generate plasma in plasma atomization gas gas path;C) atomization gas is introduced into plasma atomization gas gas path, and the atomization gas under the action of plasma forms plasma atomization gas;D) open high-voltage power supply, and sample solution is under the action of high-voltage electricity and plasma atomization gas and generates spray and forms sample ion, and the sample ion formed enters mass spectrometer by mass spectrometry inlet channel.This application can improve sensitivity, and under the premise that compound fragmentation dissociation does not occur, it is used for electric spray unfriendly solvent and difficult to detect low polarity compound detection, which can be compatible with normal phase liquid chromatography commonly used solvent, and can also reduce the influence of common complex matrix effect in electric spray ionization.

Embodiments of charged particle beam systems, components, and methods for extracting charged particles from a gas are described. In a first aspect, A charged particle source includes a resonator. The resonator can include a dielectric substrate defining a first side and a second side, the second side opposite the first side. The resonator can include a first conductive layer disposed on the first side. The first conductive layer can be disposed in accordance with a pattern comprising a ring portion. The pattern can define a gap in the ring portion of the first conductive layer. The resonator can also include a second conductive layer disposed on the second side. The charged particle source can also include a source electrode. The source electrode can be disposed proximal to the first side. The source electrode can be offset from the dielectric substrate.