46 results about "Fentanyl" patented technology

The invention relates to a hybridoma cell strain capable of secreting dextromethorphan monoclonal antibody and application of the hybridoma cell strain, and belongs to the technical field of immunodetection. The monoclonal antibody secreted by the hybridoma cell strain disclosed by the invention has good sensitivity and specificity on dextromethorphan, wherein the IC50 value on the dextromethorphan is 0.162 ng / mL. The monoclonal antibody provided by the invention has no cross reaction on structural analogues of dextromethorphan, such as fentanyl, thilazine, papaverine, morphine and medetomidine, and has good specificity, so that the dextromethorphan with low concentration can be accurately detected.

According to the fisetin nanoparticle preparation method, the fisetin nanoparticle product and the application, the synergistic effect of amino acid catalysis and a microwave or ultrasonic energy field is matched with mixing self-assembly and subsequent spray drying forming under the acidic condition, on one hand, the traditional Maillard reaction period is greatly shortened, and energy consumption is reduced; on one hand, the whole technological process of wall material preparation and active ingredient loading is simplified, the large-scale production requirement is met, on the other hand, the fisetin encapsulation effect and the nanoparticle structure stability are improved, the defects that fisetin is poor in water solubility and low in bioavailability are overcome, meanwhile, it is guaranteed that the nanoparticle product quality is uniform, the technology efficiency and the product performance superiority are considered, and the method is suitable for industrial production. The core pain points of low efficiency, poor drug loading effect and insufficient product stability of the existing traditional process are effectively overcome.

Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.

1. The name of the design product: fentanyl drugs special intelligent cabinet (table type). 2. The use of the design product: intelligent cabinet for managing and monitoring medical drugs. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

This invention discloses a method and application for detecting fentanyl and toluenethiazide using a microfluidic chip coupled with ion mobility spectrometry (IMS), belonging to the field of analytical chemistry. The method utilizes a microfluidic chip platform coupled with IMS for detection, specifically including the following steps: using a dual-channel microfluidic chip platform filled with adsorbent material, fentanyl and toluenethiazide are enriched in the sample to be tested; then, IMS is used to detect the enriched fentanyl and toluenethiazide in the sample. The detection method provided by this invention has high repeatability, minimizes operator exposure to drugs throughout the process, and greatly improves the accuracy and detection efficiency. Furthermore, the detection method provided by this invention has a short testing time, high sensitivity, and is automated and environmentally friendly, enabling rapid screening of fentanyl and toluenethiazide in multiple matrices.

1. The name of the design product: fentanyl drugs special intelligent cabinet (single-sided). 2. The use of the design product: intelligent cabinet for managing and monitoring medical drugs. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

This invention relates to the field of medical data processing technology, and discloses a method, system, device, and medium for calculating the synergistic control rate of drug infusion. The invention acquires the patient's real-time bispectral index (BSE) and determines its deviation from a preset target range. A control algorithm is then used to calculate the required total effect intensity adjustment. Based on a preset fixed ratio of propofol and remifentanil effect-site concentrations, the total effect intensity adjustment is allocated to the target effect-site concentrations of each drug. Finally, the target infusion rates of propofol and remifentanil are calculated backward using the Schnider and Minto models, respectively. This invention achieves synergistic closed-loop control of sedative and analgesic drugs based on a single BIS feedback, solving the clinical problem of unquantifiable analgesia control, ensuring a dynamic balance between sedation and analgesia, and incorporating a built-in safety verification mechanism. This significantly improves the accuracy, stability, and safety of anesthesia depth control, while reducing clinical workload.

Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.

The invention provides a fentanyl drug full-cycle circulation traceability management system, and relates to the technical field of data traceability, and the system comprises a batch coding module which is used for distributing a unique batch number for each drug batch according to standardized data, and forming a drug traceability data block; the block chain evidence storage module is used for uploading the drug traceability data blocks to a block chain network through a consensus mechanism for distributed storage, and generating a unique hash value and a timestamp for each data block; and mapping the key space-time attribute of each data block into a circular geometric feature. According to the method, through unique batch coding, block chain distributed evidence storage, geometric feature association verification and hierarchical spherical spatial index construction, safe tamper-proof, association credibility and rapid positioning query of fentanyl drug full-cycle circulation data are realized, and efficient and reliable support is provided for drug full-life-cycle traceability.

The invention relates to a transmission desorption electrospray low-pressure ion mobility spectrometry which comprises a transmission desorption electrospray ion source, an interface electrode and a low-pressure ion migration tube, the interface electrode is a metal sheet electrode with a through hole in the center, and the transmission desorption electrospray ion source is connected with the low-pressure ion migration tube through the interface electrode. The ion mobility spectrometry can realize efficient desorption spray ionization of substances difficult to volatilize in the detection process, the sample detection process is simplified, the working air pressure is lower than the atmospheric pressure, the detection sensitivity can be improved, furthermore, the ion mobility spectrometry is provided with a desolvation area and is combined with desolvation gas, the detection sensitivity can be further improved, and the detection accuracy is improved. High-sensitivity detection of anesthetic drugs such as propofol, etomidate, fentanyl and the like in blood can be realized through transmission-type desorption electrospray and low-pressure ion mobility spectrometry.

This invention belongs to the field of electrochemiluminescence and provides an electrochemiluminescence aptamer sensor for the detection of isobutyryl fentanyl (IBF), its preparation, and its application. An apt@Ni-MOFs / cDNA / Ag-MOGs / SiO2 electrode with electroluminescence and specific recognition properties is modified onto the surface of a glassy carbon electrode (GCE) to form the modified electrode apt@Ni-MOFs / cDNA / Ag-MOGs / SiO2 / GCE. This modified electrode is used as the working electrode, an Ag / AgCl electrode as the reference electrode, and a platinum electrode as the counter electrode. IBF was detected by electrochemiluminescence in a PBS buffer solution containing 0.15 mol / L K2S2O8 at pH 7.4, and the corresponding regression equation was obtained; ΔECL = 2.4 × 10⁻⁶. 4 + 1.6×10 3 ×log C (g / L), correlation coefficient R 2 =0.999, detection limit is 3.3 × 10 –15 g / L. This invention exhibits good selectivity, high sensitivity, and a wide linear range.

The application provides a fentanyl drug full-cycle circulation traceability management system, and relates to the technical field of data traceability, comprising: a batch coding module for assigning a unique batch number to each drug batch according to standardized data to form a drug traceability data block; a blockchain storage module for uploading the drug traceability data block to a blockchain network for distributed storage through a consensus mechanism, generating a unique hash value and a timestamp for each data block; and mapping the key space-time attributes of each data block into a circular geometric feature. The application realizes the secure anti-tampering, correlation credibility and rapid positioning query of fentanyl drug full-cycle circulation data through unique batch coding, blockchain distributed storage, geometric feature correlation verification and hierarchical spherical space indexing construction, and provides efficient and reliable support for drug full-life-cycle traceability.

The invention relates to the technical field of medicine management and control, in particular to a fentanyl medicine full-process tracing control method, which is applied to intelligent management and control equipment, and realizes full-life-cycle closed-loop tracing through six core stages of equipment initialization, warehousing, storage, ex-warehouse, recovery and emergency. In the warehousing stage, double identity verification and double verification recognition assembly cross verification are adopted, and compliance of medicine and personnel information is guaranteed; in the storage stage, real-time monitoring and intelligent regulation and control of temperature and humidity are realized through multi-sensor fusion and an improved moving average algorithm; in the emergency stage, a UPS standby power supply and an emergency lock are adopted for dual guarantee, and medicine accessibility and operation traceability in a power-off scene are ensured; and the traceability data is stored through a block chain technology, and data non-tampering and secure access are realized in combination with three-level permission verification. The normativity, accuracy and reliability of fentanyl drug management and control are improved, and the method is suitable for the requirements of hospitals, drug treatment institutes and other scenes and has important application value.

The invention discloses a four-in-one rapid detection kit for fentanyl, carfentanyl, selazine and niash based on a heat-resistant antibody IgY, and belongs to the technical field of biology. The method comprises the following steps: preparing four detection test strips of fentanyl, carfentanyl, cellazine and niash by adopting heat-resistant antibodies IgY of fentanyl, carfentanyl, cellazine, niash and the like and a colloidal carbon competitive immunochromatography method, and assembling the four detection test strips on a quadruple card inserting plate; the kit can be used for one-time rapid detection of components possibly containing fentanyl, carfentanyl, selazine and niash in a sample, and has the characteristic of tolerance to the high temperature of 65 DEG C without inactivation. Besides, dozens of types of fentanyl and derivatives thereof exist at present, a single fentanyl or carfentanyl detection strip can leak a lot of fentanyl derivatives, and the detection sensitivity of the fentanyl and carfentanyl detection strips to the types of fentanyl derivatives is complementary, so that more types of fentanyl derivatives can be detected.

The present application relates to a deuterium-labeled psychoactive substance, which has a chemical structural formula as shown in the description.The present application also provides a preparation method of the deuterium-labeled psychoactive substance, which comprises the following steps: (1) removing the methyl group of sufentanil under the action of a demethylating agent to generate a demethylated intermediate; (2) reacting the demethylated intermediate with a deuterated methyl reagent to generate the deuterium-labeled sufentanil.The present application also provides the use of the deuterium-labeled sufentanil in detecting the content of sufentanil in biological samples or environmental samples.

1. The name of the design product: fentanyl drugs special intelligent cabinet (vertical). 2. The use of the design product: intelligent cabinet for managing and monitoring medical drugs. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The present application relates to a kind of surface enhanced raman nanoparticles and fentanyl substance detection method, belong to the field of drug safety detection.The surface enhanced raman nanoparticles is noble metal nanoparticle, the noble metal nanoparticle is preferably gold nanobiscake.The fentanyl substance detection method uses the surface enhanced raman nanoparticles of the present application to carry out raman detection.The surface enhanced raman nanoparticles and fentanyl substance detection method can quickly, non-destructively detect trace fentanyl substance in the sample to be measured, and has very good application prospect in public safety detection.

The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. The compound of Formula (I) is used as hapten and is useful as an antigen in a vaccine for a disease, (e.g., opioid addiction). Also provided in the present disclosure are vaccines, pharmaceutical compositions, kits, methods, and uses including or using compounds of Formula (I) and compositions comprising compounds of Formula (I).

Certain embodiments provide an isolated antibody or fragment thereof having affinity for fentanyl or analog thereof, CA as well as methods of use thereof. Certain embodiments provide a method for treating fentanyl or analog related overdose, poisoning, or disorder.

The application relates to a surface enhanced Raman spectroscopy (SERS) substrate, and relates to a kit containing the substrate and a method for detecting a fentanyl compound in a sample by using the substrate, and relates to the use of the substrate and the kit for detecting the fentanyl compound in the sample.

The utility model relates to the technical field of deodorant packaging, in particular to a suspension type deodorant transparent packaging bottle which comprises a transparent packaging bottle body, a bottle neck prismatic table, a bottle opening and a bottle cap, the top of the transparent packaging bottle body is communicated with the bottle neck prismatic table, and the top of the bottle neck prismatic table is communicated with the bottle opening. A bottle opening boss is arranged at the top of the bottle opening, and a filter screen is laid at the top of the bottle opening boss; a pressing ring is arranged at the top end of the boss of the bottle opening and located on the outer edge of the top of the filter screen in a press fit mode, plastic screws are installed on the pressing ring at equal intervals through screw holes, a bottle cap is screwed on the bottle opening, and a hanging ring is connected to the top of the transparent packaging bottle and located at one end of the prismatic table of the bottle neck through a hanging piece. The deodorant transparent packaging bottle is hung on a wall positioning screw, so that the deodorant transparent packaging bottle can be conveniently and orderly stored, sediments and other solid particles in deodorants such as phytoncide and peppermint oil can be conveniently filtered, and the use effect of pouring out the deodorants is improved.

A method for non-invasively determining a physiological state of interest in a subject is described. The method involves, placing a body part in contact with a receptor, and directing a source of electromagnetic radiation (EMR) over a range of wavelengths onto body part so that the EMR reaches the blood and interstitial fluid within the body part. The EMR that is absorbed by, reflected by, or transmitted through, the blood and interstitial fluid of the body part is measured, and a spectrum over the range of wavelengths obtained. The spectrum is analyzed to determine an amount of two or more than two analytes within the blood and interstitial fluid of the body part and a biochemical profile is derived. The biochemical profile is used to determine the physiological state of interest in the subject. The physiological state of interest in the subject may be selected from the group of intoxication arising from cannabis, alcohol, a combination of cannabis and alcohol, opiates, fentanyl, amphetamines, phencyclidine, sedatives, anxyolytics, cocaine, caffeine, and nicotine consumption.

1. Name of the design product: detection box (detection of fentanyl). 2. Use of the design product: detection box for detecting fentanyl. 3. Design points of the design product: in shape. 4. Picture or photo best indicating the design points: front view.

1. The name of the design product: fentanyl drug special intelligent cabinet (FTNG-T-DR-01). 2. The use of the design product: for the storage and access management of drugs. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.

The invention discloses a multi-stage image enhancement method and system for anesthetic psychotropic drug identification. The method comprises the following steps: obtaining an original anesthetic psychotropic drug color image in a complex scene; gaussian filtering processing is carried out on the original image to suppress image noise, and a filtered image is obtained; performing weighted gray level conversion processing on the filtered image, and converting a color image into a gray level image by using a weight coefficient based on human visual characteristics; performing single-scale Retinex processing on the grayscale image, and estimating and separating illumination components to correct illumination unevenness and suppress reflection interference to obtain a final enhanced image; and outputting the final enhanced image for recognition of a subsequent target detection model. The method has the beneficial effects that after the technical scheme is subjected to multi-stage enhancement, the mAP50 of the target detection model is improved to 99.31% from 82.09% of an original image, and the recognition accuracy of 36 types of drugs such as propofol and fentanyl reaches a clinical practical standard.

The application provides a method for detecting psychotropic drugs in environmental sludge based on alkaline pretreatment, and comprises the following steps: S1: obtaining a to-be-detected sludge sample, performing pressurized fluid extraction on the to-be-detected sludge sample after freeze-drying to obtain an extraction solution, performing solid-phase extraction on the extraction solution to obtain an elution solution, and redissolving the elution solution to obtain a to-be-detected solution, wherein the pressurized fluid extraction is performed in 1 ‰ ammonia water without heating; and S2: performing liquid chromatography mass spectrometry on the to-be-detected solution to obtain a mass spectrum, and the psychotropic drug is one of morphine, acetylfentanyl and THC-COOH or a combination of two or more thereof, so that the detection of multiple psychotropic drugs in the environmental sludge is realized.

The invention discloses a fentanyl hapten and a complete antigen and application thereof, the structure of the fentanyl hapten is as shown in formula (I), the fentanyl hapten retains the whole structure of fentanyl, and the fentanyl hapten can be used for preparing the fentanyl complete antigen. The monoclonal antibody prepared based on the fentanyl complete antigen has high affinity to fentanyl and strong specificity, and can be used for efficiently detecting the content of fentanyl and fentanyl analogues in a biological sample by enzyme-linked immunosorbent assay or colloidal gold immunochromatography. Wherein the preferable monoclonal antibody can specifically recognize the p-methoxy fentanyl, so that the detection range of the fentanyl analogue is further expanded. Formula (I).

The application discloses a construction method and application of a carfentanyl mouse withdrawal model, and belongs to the field of biological medicine technology and animal model construction; carfentanyl is injected into the mouse, and the injection period is 6 days; 2 injections are injected every day in the first 5 days, and the interval between the injections is 12 hours; the injection dose of each injection on the nth day is n times of the injection dose of each injection on the first day; one injection is injected on the sixth day, and the injection dose is the same as the injection dose of each injection on the fifth day; the withdrawal is carried out after the injection is completed to obtain the carfentanyl mouse withdrawal model; the model of the application has fewer drug administration days, fewer drug administration times and uses less medicine, compared with the model constructed in the foregoing research; the model of the application has fewer drug administration days, fewer drug administration times and uses less medicine, and provides more economical, more efficient and more comprehensive reference evidence for the addiction and harmfulness of carfentanyl; the model can be widely applied to related researches such as pharmacological action evaluation or drug treatment of carfentanyl and similar new psychoactive substances.

The application of fentanyl or its analogues as plant growth regulators belongs to the technical field of plant growth regulators. To screen plant growth regulators from microbial sources, this invention provides a plant growth regulator containing an aqueous solution of fentanyl or its analogues, with a concentration of fentanyl or its analogues ranging from 15 μg / L to 1500 μg / L. This invention studied the effects of fentanyl and its analogues on plant growth and development using seed germination experiments, pot experiments, and field experiments. It was found that fentanyl and its analogues can promote the germination of rice, corn, and soybean seeds, increase tillering and yield in rice, and promote the growth of cucumber, tomato, bok choy, spinach, and lettuce seedlings. As a novel, highly efficient, low-toxicity, and low-cost plant growth regulator, it has development and utilization value and application prospects in agricultural production.

A portable detection kit for identifying the presence of narcotic compounds (NCs) includes at least one chemical dye, a catalytic reagent, at least one solvent, and a least one surfactant. The at least one dry chemical dye is configured to undergo physic-chemical interaction with at least one predetermined NC to produce a color visible change. The at least one predetermined NC is selected from the group consisting of fentanyl analogues (FAs) and narcotics containing nitrogen heterocyclic moiety.