72 results about "Fentanyl" patented technology

The invention relates to a hybridoma cell strain capable of secreting dextromethorphan monoclonal antibody and application of the hybridoma cell strain, and belongs to the technical field of immunodetection. The monoclonal antibody secreted by the hybridoma cell strain disclosed by the invention has good sensitivity and specificity on dextromethorphan, wherein the IC50 value on the dextromethorphan is 0.162 ng / mL. The monoclonal antibody provided by the invention has no cross reaction on structural analogues of dextromethorphan, such as fentanyl, thilazine, papaverine, morphine and medetomidine, and has good specificity, so that the dextromethorphan with low concentration can be accurately detected.

According to the fisetin nanoparticle preparation method, the fisetin nanoparticle product and the application, the synergistic effect of amino acid catalysis and a microwave or ultrasonic energy field is matched with mixing self-assembly and subsequent spray drying forming under the acidic condition, on one hand, the traditional Maillard reaction period is greatly shortened, and energy consumption is reduced; on one hand, the whole technological process of wall material preparation and active ingredient loading is simplified, the large-scale production requirement is met, on the other hand, the fisetin encapsulation effect and the nanoparticle structure stability are improved, the defects that fisetin is poor in water solubility and low in bioavailability are overcome, meanwhile, it is guaranteed that the nanoparticle product quality is uniform, the technology efficiency and the product performance superiority are considered, and the method is suitable for industrial production. The core pain points of low efficiency, poor drug loading effect and insufficient product stability of the existing traditional process are effectively overcome.

The invention relates to the technical field of detection and identification of fentanyl substances, and discloses a selective quantitative detection method of fentanyl. According to the method, a differential pulse voltammetry (DPV) is used for making a linear relation diagram of a potassium ferricyanide peak current and fentanyl solutions with different concentrations to obtain a standard working curve, a linear equation is obtained through the standard curve, and the detection limit is 1.0 * 10 <-12 > mol.L <-1 >; the molecularly imprinted membrane modified electrode prepared by the invention is used for measuring the peak current of a potassium ferricyanide solution, so that fentanyl molecules can be indirectly and quantitatively analyzed and measured. The method is characterized in that a fentanyl molecularly imprinted membrane is electrically polymerized on the surface of a glassy carbon electrode, m-phenylenediamine is used as a functional monomer, and the selectivity and sensitivity of an electrochemical method for detecting fentanyl are improved. Meanwhile, by taking an adsorption pulse stripping voltammetry (DPASV) as a detection technology, a method capable of rapidly detecting fentanyl molecules in the presence of various drugs is established. The molecularly imprinted membrane electrode disclosed by the invention is simple to prepare, quick in response and good in selectivity and reproducibility, and can be repeatedly used for more than five times.

Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.

1. The name of the design product: fentanyl drugs special intelligent cabinet (table type). 2. The use of the design product: intelligent cabinet for managing and monitoring medical drugs. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

This invention discloses a method and application for detecting fentanyl and toluenethiazide using a microfluidic chip coupled with ion mobility spectrometry (IMS), belonging to the field of analytical chemistry. The method utilizes a microfluidic chip platform coupled with IMS for detection, specifically including the following steps: using a dual-channel microfluidic chip platform filled with adsorbent material, fentanyl and toluenethiazide are enriched in the sample to be tested; then, IMS is used to detect the enriched fentanyl and toluenethiazide in the sample. The detection method provided by this invention has high repeatability, minimizes operator exposure to drugs throughout the process, and greatly improves the accuracy and detection efficiency. Furthermore, the detection method provided by this invention has a short testing time, high sensitivity, and is automated and environmentally friendly, enabling rapid screening of fentanyl and toluenethiazide in multiple matrices.

The present disclosure relates to a method of treatment or prophylaxis of a preterm infant by administering intravenously a therapeutic amount of a composition comprising IGF-1 and IBGBP-3 in combination with a therapy selected from the group comprising: caffeine, fentanyl, fluconazole, gentamicin, insulin, midazolam, morphine, low dose norepinephrine, vancomycin concentrations of 5 mg / ml or less, parenteral nutrition (or a composition for the same use) and combinations thereof.

1. The name of the design product: fentanyl drugs special intelligent cabinet (single-sided). 2. The use of the design product: intelligent cabinet for managing and monitoring medical drugs. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

This invention relates to the field of medical data processing technology, and discloses a method, system, device, and medium for calculating the synergistic control rate of drug infusion. The invention acquires the patient's real-time bispectral index (BSE) and determines its deviation from a preset target range. A control algorithm is then used to calculate the required total effect intensity adjustment. Based on a preset fixed ratio of propofol and remifentanil effect-site concentrations, the total effect intensity adjustment is allocated to the target effect-site concentrations of each drug. Finally, the target infusion rates of propofol and remifentanil are calculated backward using the Schnider and Minto models, respectively. This invention achieves synergistic closed-loop control of sedative and analgesic drugs based on a single BIS feedback, solving the clinical problem of unquantifiable analgesia control, ensuring a dynamic balance between sedation and analgesia, and incorporating a built-in safety verification mechanism. This significantly improves the accuracy, stability, and safety of anesthesia depth control, while reducing clinical workload.

The invention discloses a label-free ratio fluorescence sensor and a method for detecting fentanyl substances, and belongs to the field of analysis and detection.The sensor comprises a recognition element, the recognition element comprises six kinds of guanine-rich DNA aptamers and a signal conversion element, and the signal conversion element comprises a fluorescent dye. According to the invention, a plurality of fentanyl analogues can be rapidly detected.

The invention relates to a dosing regimen for sedation with the fast-acting benzodiazepine CNS 7056 in combination with an opioid, in particular fentanyl, whereas CNS 7056 is given in a dose of 2 to 20 mg, preferably between 4 and 9 mg and most preferably between 5 and 8 mg.

Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.

The invention provides a fentanyl drug full-cycle circulation traceability management system, and relates to the technical field of data traceability, and the system comprises a batch coding module which is used for distributing a unique batch number for each drug batch according to standardized data, and forming a drug traceability data block; the block chain evidence storage module is used for uploading the drug traceability data blocks to a block chain network through a consensus mechanism for distributed storage, and generating a unique hash value and a timestamp for each data block; and mapping the key space-time attribute of each data block into a circular geometric feature. According to the method, through unique batch coding, block chain distributed evidence storage, geometric feature association verification and hierarchical spherical spatial index construction, safe tamper-proof, association credibility and rapid positioning query of fentanyl drug full-cycle circulation data are realized, and efficient and reliable support is provided for drug full-life-cycle traceability.

An improved formulation may include an enhanced ability relative to its predicates to destroy toxic threats in the form of sporulated bacteria, bacteria protected by biofilms, planktonic bacteria, fungus, viruses, chemical weapons, toxic chemicals including Fentanyl, its analogs, and a whole host of toxic industrial chemicals. The formulation may include a three part product composed of a buffered detergent chemical system, a hydrogen peroxide chemical system and an accelerator system designed to deliver activated peroxygen species when blended together.

The invention relates to a transmission desorption electrospray low-pressure ion mobility spectrometry which comprises a transmission desorption electrospray ion source, an interface electrode and a low-pressure ion migration tube, the interface electrode is a metal sheet electrode with a through hole in the center, and the transmission desorption electrospray ion source is connected with the low-pressure ion migration tube through the interface electrode. The ion mobility spectrometry can realize efficient desorption spray ionization of substances difficult to volatilize in the detection process, the sample detection process is simplified, the working air pressure is lower than the atmospheric pressure, the detection sensitivity can be improved, furthermore, the ion mobility spectrometry is provided with a desolvation area and is combined with desolvation gas, the detection sensitivity can be further improved, and the detection accuracy is improved. High-sensitivity detection of anesthetic drugs such as propofol, etomidate, fentanyl and the like in blood can be realized through transmission-type desorption electrospray and low-pressure ion mobility spectrometry.

Nicotine delivery devices and systems, particularly smoking cessation systems are provided by the present disclosure. Such devices and systems produce a nicotine-containing aerosol for inhalation that mimics smoking. The devices are capable of being adapted to control the amount of nicotine delivered to taper the amount of nicotine delivered to the user over time. Methods for treating patients to stop smoking are also disclosed. The devices, systems and methods can also be used to deliver other drugs disclosed herein, such as opioids (e.g., fentanyl).

This invention belongs to the field of electrochemiluminescence and provides an electrochemiluminescence aptamer sensor for the detection of isobutyryl fentanyl (IBF), its preparation, and its application. An apt@Ni-MOFs / cDNA / Ag-MOGs / SiO2 electrode with electroluminescence and specific recognition properties is modified onto the surface of a glassy carbon electrode (GCE) to form the modified electrode apt@Ni-MOFs / cDNA / Ag-MOGs / SiO2 / GCE. This modified electrode is used as the working electrode, an Ag / AgCl electrode as the reference electrode, and a platinum electrode as the counter electrode. IBF was detected by electrochemiluminescence in a PBS buffer solution containing 0.15 mol / L K2S2O8 at pH 7.4, and the corresponding regression equation was obtained; ΔECL = 2.4 × 10⁻⁶. 4 + 1.6×10 3 ×log C (g / L), correlation coefficient R 2 =0.999, detection limit is 3.3 × 10 –15 g / L. This invention exhibits good selectivity, high sensitivity, and a wide linear range.

The application provides a fentanyl drug full-cycle circulation traceability management system, and relates to the technical field of data traceability, comprising: a batch coding module for assigning a unique batch number to each drug batch according to standardized data to form a drug traceability data block; a blockchain storage module for uploading the drug traceability data block to a blockchain network for distributed storage through a consensus mechanism, generating a unique hash value and a timestamp for each data block; and mapping the key space-time attributes of each data block into a circular geometric feature. The application realizes the secure anti-tampering, correlation credibility and rapid positioning query of fentanyl drug full-cycle circulation data through unique batch coding, blockchain distributed storage, geometric feature correlation verification and hierarchical spherical space indexing construction, and provides efficient and reliable support for drug full-life-cycle traceability.

The invention relates to the technical field of medicine management and control, in particular to a fentanyl medicine full-process tracing control method, which is applied to intelligent management and control equipment, and realizes full-life-cycle closed-loop tracing through six core stages of equipment initialization, warehousing, storage, ex-warehouse, recovery and emergency. In the warehousing stage, double identity verification and double verification recognition assembly cross verification are adopted, and compliance of medicine and personnel information is guaranteed; in the storage stage, real-time monitoring and intelligent regulation and control of temperature and humidity are realized through multi-sensor fusion and an improved moving average algorithm; in the emergency stage, a UPS standby power supply and an emergency lock are adopted for dual guarantee, and medicine accessibility and operation traceability in a power-off scene are ensured; and the traceability data is stored through a block chain technology, and data non-tampering and secure access are realized in combination with three-level permission verification. The normativity, accuracy and reliability of fentanyl drug management and control are improved, and the method is suitable for the requirements of hospitals, drug treatment institutes and other scenes and has important application value.

The invention discloses a four-in-one rapid detection kit for fentanyl, carfentanyl, selazine and niash based on a heat-resistant antibody IgY, and belongs to the technical field of biology. The method comprises the following steps: preparing four detection test strips of fentanyl, carfentanyl, cellazine and niash by adopting heat-resistant antibodies IgY of fentanyl, carfentanyl, cellazine, niash and the like and a colloidal carbon competitive immunochromatography method, and assembling the four detection test strips on a quadruple card inserting plate; the kit can be used for one-time rapid detection of components possibly containing fentanyl, carfentanyl, selazine and niash in a sample, and has the characteristic of tolerance to the high temperature of 65 DEG C without inactivation. Besides, dozens of types of fentanyl and derivatives thereof exist at present, a single fentanyl or carfentanyl detection strip can leak a lot of fentanyl derivatives, and the detection sensitivity of the fentanyl and carfentanyl detection strips to the types of fentanyl derivatives is complementary, so that more types of fentanyl derivatives can be detected.

The present application relates to a deuterium-labeled psychoactive substance, which has a chemical structural formula as shown in the description.The present application also provides a preparation method of the deuterium-labeled psychoactive substance, which comprises the following steps: (1) removing the methyl group of sufentanil under the action of a demethylating agent to generate a demethylated intermediate; (2) reacting the demethylated intermediate with a deuterated methyl reagent to generate the deuterium-labeled sufentanil.The present application also provides the use of the deuterium-labeled sufentanil in detecting the content of sufentanil in biological samples or environmental samples.

1. The name of the design product: fentanyl drugs special intelligent cabinet (vertical). 2. The use of the design product: intelligent cabinet for managing and monitoring medical drugs. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The present application relates to a kind of surface enhanced raman nanoparticles and fentanyl substance detection method, belong to the field of drug safety detection.The surface enhanced raman nanoparticles is noble metal nanoparticle, the noble metal nanoparticle is preferably gold nanobiscake.The fentanyl substance detection method uses the surface enhanced raman nanoparticles of the present application to carry out raman detection.The surface enhanced raman nanoparticles and fentanyl substance detection method can quickly, non-destructively detect trace fentanyl substance in the sample to be measured, and has very good application prospect in public safety detection.

The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. The compound of Formula (I) is used as hapten and is useful as an antigen in a vaccine for a disease, (e.g., opioid addiction). Also provided in the present disclosure are vaccines, pharmaceutical compositions, kits, methods, and uses including or using compounds of Formula (I) and compositions comprising compounds of Formula (I).

The invention relates to a fentanyl detection kit and a detection method, and belongs to the technical field of detection, the fentanyl detection kit comprises a fentanyl detection reagent strip, the reagent strip comprises a sample pad, a binding pad and a nitrocellulose membrane which are connected in sequence, the binding pad is coated with a nano antibody specifically binding to fentanyl, and the nitrocellulose membrane is coated with a nano antibody specifically binding to fentanyl. The nano antibody comprises a CDR sequence as shown in SEQ ID NO: 2-4. The fentanyl kit disclosed by the invention has high sensitivity and can be used for synchronously detecting various fentanyl analogues.

Certain embodiments provide an isolated antibody or fragment thereof having affinity for fentanyl or analog thereof, CA as well as methods of use thereof. Certain embodiments provide a method for treating fentanyl or analog related overdose, poisoning, or disorder.

The application relates to a surface enhanced Raman spectroscopy (SERS) substrate, and relates to a kit containing the substrate and a method for detecting a fentanyl compound in a sample by using the substrate, and relates to the use of the substrate and the kit for detecting the fentanyl compound in the sample.

The utility model relates to the technical field of deodorant packaging, in particular to a suspension type deodorant transparent packaging bottle which comprises a transparent packaging bottle body, a bottle neck prismatic table, a bottle opening and a bottle cap, the top of the transparent packaging bottle body is communicated with the bottle neck prismatic table, and the top of the bottle neck prismatic table is communicated with the bottle opening. A bottle opening boss is arranged at the top of the bottle opening, and a filter screen is laid at the top of the bottle opening boss; a pressing ring is arranged at the top end of the boss of the bottle opening and located on the outer edge of the top of the filter screen in a press fit mode, plastic screws are installed on the pressing ring at equal intervals through screw holes, a bottle cap is screwed on the bottle opening, and a hanging ring is connected to the top of the transparent packaging bottle and located at one end of the prismatic table of the bottle neck through a hanging piece. The deodorant transparent packaging bottle is hung on a wall positioning screw, so that the deodorant transparent packaging bottle can be conveniently and orderly stored, sediments and other solid particles in deodorants such as phytoncide and peppermint oil can be conveniently filtered, and the use effect of pouring out the deodorants is improved.

A method for non-invasively determining a physiological state of interest in a subject is described. The method involves, placing a body part in contact with a receptor, and directing a source of electromagnetic radiation (EMR) over a range of wavelengths onto body part so that the EMR reaches the blood and interstitial fluid within the body part. The EMR that is absorbed by, reflected by, or transmitted through, the blood and interstitial fluid of the body part is measured, and a spectrum over the range of wavelengths obtained. The spectrum is analyzed to determine an amount of two or more than two analytes within the blood and interstitial fluid of the body part and a biochemical profile is derived. The biochemical profile is used to determine the physiological state of interest in the subject. The physiological state of interest in the subject may be selected from the group of intoxication arising from cannabis, alcohol, a combination of cannabis and alcohol, opiates, fentanyl, amphetamines, phencyclidine, sedatives, anxyolytics, cocaine, caffeine, and nicotine consumption.

The invention discloses a fentanyl medicine intelligent cabinet and a control system and method. Comprising a medicine storage module used for storing medicines, a medicine adding module used for adding information manually according to RFID tags, a medicine taking module used for taking the medicines only after on-site authorization or remote authorization, a medicine returning module used for checking the medicines through the RFID tags, and an empty bottle recycling and residual liquid collecting module. The system is provided with a medicine storage module for storing medicines, a medicine adding module for adding information according to an RFID tag and manpower, a medicine taking module for taking the medicines only after field authorization or remote authorization, a medicine returning module for checking the medicines through the RFID tag, and an empty bottle recycling and residual liquid collecting module. A good man-machine interaction function is achieved, medicine information can be conveniently imported through the RFID tag, the information of the medicine can be accurately read when the medicine is taken and returned, and warehouse-in and warehouse-out checking is facilitated.