93 results about "Fentanyl" patented technology

The invention relates to a hybridoma cell strain capable of secreting dextromethorphan monoclonal antibody and application of the hybridoma cell strain, and belongs to the technical field of immunodetection. The monoclonal antibody secreted by the hybridoma cell strain disclosed by the invention has good sensitivity and specificity on dextromethorphan, wherein the IC50 value on the dextromethorphan is 0.162 ng / mL. The monoclonal antibody provided by the invention has no cross reaction on structural analogues of dextromethorphan, such as fentanyl, thilazine, papaverine, morphine and medetomidine, and has good specificity, so that the dextromethorphan with low concentration can be accurately detected.

According to the fisetin nanoparticle preparation method, the fisetin nanoparticle product and the application, the synergistic effect of amino acid catalysis and a microwave or ultrasonic energy field is matched with mixing self-assembly and subsequent spray drying forming under the acidic condition, on one hand, the traditional Maillard reaction period is greatly shortened, and energy consumption is reduced; on one hand, the whole technological process of wall material preparation and active ingredient loading is simplified, the large-scale production requirement is met, on the other hand, the fisetin encapsulation effect and the nanoparticle structure stability are improved, the defects that fisetin is poor in water solubility and low in bioavailability are overcome, meanwhile, it is guaranteed that the nanoparticle product quality is uniform, the technology efficiency and the product performance superiority are considered, and the method is suitable for industrial production. The core pain points of low efficiency, poor drug loading effect and insufficient product stability of the existing traditional process are effectively overcome.

Nicotine delivery devices and systems, particularly smoking cessation systems are provided by the present disclosure. Such devices and systems produce a nicotine-containing aerosol for inhalation that mimics smoking. The devices are capable of being adapted to control the amount of nicotine delivered to taper the amount of nicotine delivered to the user over time. Methods for treating patients to stop smoking are also disclosed. The devices, systems and methods can also be used to deliver other drugs disclosed herein, such as opioids (e.g., fentanyl).

1. Name of the product of this design: Smart Cabinet for Fentanyl Drugs (FTNG‑T‑DS01). 2. Purpose of this design product: used for storing items. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: main view.

1. Name of the product of this design: Smart Cabinet for Fentanyl Drugs (FTNG‑L‑DS02). 2. Purpose of this design product: used for storing items. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: main view.

The invention relates to the technical field of detection and identification of fentanyl substances, and discloses a selective quantitative detection method of fentanyl. According to the method, a differential pulse voltammetry (DPV) is used for making a linear relation diagram of a potassium ferricyanide peak current and fentanyl solutions with different concentrations to obtain a standard working curve, a linear equation is obtained through the standard curve, and the detection limit is 1.0 * 10 <-12 > mol.L <-1 >; the molecularly imprinted membrane modified electrode prepared by the invention is used for measuring the peak current of a potassium ferricyanide solution, so that fentanyl molecules can be indirectly and quantitatively analyzed and measured. The method is characterized in that a fentanyl molecularly imprinted membrane is electrically polymerized on the surface of a glassy carbon electrode, m-phenylenediamine is used as a functional monomer, and the selectivity and sensitivity of an electrochemical method for detecting fentanyl are improved. Meanwhile, by taking an adsorption pulse stripping voltammetry (DPASV) as a detection technology, a method capable of rapidly detecting fentanyl molecules in the presence of various drugs is established. The molecularly imprinted membrane electrode disclosed by the invention is simple to prepare, quick in response and good in selectivity and reproducibility, and can be repeatedly used for more than five times.

Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.

1. The name of the design product: fentanyl drugs special intelligent cabinet (table type). 2. The use of the design product: intelligent cabinet for managing and monitoring medical drugs. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

This invention discloses a method and application for detecting fentanyl and toluenethiazide using a microfluidic chip coupled with ion mobility spectrometry (IMS), belonging to the field of analytical chemistry. The method utilizes a microfluidic chip platform coupled with IMS for detection, specifically including the following steps: using a dual-channel microfluidic chip platform filled with adsorbent material, fentanyl and toluenethiazide are enriched in the sample to be tested; then, IMS is used to detect the enriched fentanyl and toluenethiazide in the sample. The detection method provided by this invention has high repeatability, minimizes operator exposure to drugs throughout the process, and greatly improves the accuracy and detection efficiency. Furthermore, the detection method provided by this invention has a short testing time, high sensitivity, and is automated and environmentally friendly, enabling rapid screening of fentanyl and toluenethiazide in multiple matrices.

The present disclosure relates to a method of treatment or prophylaxis of a preterm infant by administering intravenously a therapeutic amount of a composition comprising IGF-1 and IBGBP-3 in combination with a therapy selected from the group comprising: caffeine, fentanyl, fluconazole, gentamicin, insulin, midazolam, morphine, low dose norepinephrine, vancomycin concentrations of 5 mg / ml or less, parenteral nutrition (or a composition for the same use) and combinations thereof.

1. The name of the design product: fentanyl drugs special intelligent cabinet (single-sided). 2. The use of the design product: intelligent cabinet for managing and monitoring medical drugs. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

This invention relates to the field of medical data processing technology, and discloses a method, system, device, and medium for calculating the synergistic control rate of drug infusion. The invention acquires the patient's real-time bispectral index (BSE) and determines its deviation from a preset target range. A control algorithm is then used to calculate the required total effect intensity adjustment. Based on a preset fixed ratio of propofol and remifentanil effect-site concentrations, the total effect intensity adjustment is allocated to the target effect-site concentrations of each drug. Finally, the target infusion rates of propofol and remifentanil are calculated backward using the Schnider and Minto models, respectively. This invention achieves synergistic closed-loop control of sedative and analgesic drugs based on a single BIS feedback, solving the clinical problem of unquantifiable analgesia control, ensuring a dynamic balance between sedation and analgesia, and incorporating a built-in safety verification mechanism. This significantly improves the accuracy, stability, and safety of anesthesia depth control, while reducing clinical workload.

The invention discloses a label-free ratio fluorescence sensor and a method for detecting fentanyl substances, and belongs to the field of analysis and detection.The sensor comprises a recognition element, the recognition element comprises six kinds of guanine-rich DNA aptamers and a signal conversion element, and the signal conversion element comprises a fluorescent dye. According to the invention, a plurality of fentanyl analogues can be rapidly detected.

The invention relates to a dosing regimen for sedation with the fast-acting benzodiazepine CNS 7056 in combination with an opioid, in particular fentanyl, whereas CNS 7056 is given in a dose of 2 to 20 mg, preferably between 4 and 9 mg and most preferably between 5 and 8 mg.

The invention is suitable for the technical field of medical instruments, and provides an infusion analgesia patch which comprises a backing layer, an inner cavity is formed in the backing layer, a hardening layer is arranged at the upper end of the backing layer, the hardening layer is arranged above the inner cavity, the hardening layer is used for blocking an upper end opening of the inner cavity, the hardening layer is fixedly connected to the backing layer, and materials on the sides of the inner cavity are subjected to hardening treatment. The inner cavity is internally provided with an isolating layer, the isolating layer is fixedly connected with the hardened inner side face of the inner cavity, the inner cavity is internally provided with a controlled release film, fentanyl is released through the controlled release film and is absorbed by skin, fentanyl is combined with an opioid receptor in a body, transmission and perception of pain signals are inhibited, and therefore the analgesic effect is achieved. The puncture microneedle penetrates through the controlled release membrane and the cotton cloth layer and can puncture the cuticle of the skin in a minimally invasive mode, and a reversible microchannel is formed on the surface of the skin. The micro-channels provide a direct skin entering path for medicine molecules, so that the transdermal efficiency is greatly improved.

Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.

The invention relates to a pharmaceutical composition for intraoperative brain protection in shoulder arthroscopy surgery. The pharmaceutical composition comprises midazolam, propofol, sufentanil, succinylcholine and atracurium besylate. According to the invention, rScO2 can be improved, the risk of cerebrovascular events can be reduced, but no obvious influence is generated on the circulation stability in the operation of a patient, the postoperative cognitive impairment and the like.

Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.

The invention discloses a detection method and a preparation method of a fentanyl surface enhanced Raman spectroscopy test strip which are rapid, sensitive and simple and convenient to operate. The test strip comprises a sample pad, a combination pad, an NC membrane, a water absorption pad and a PVC bottom plate. A sample pad, a combination pad, an NC (nitrocellulose) membrane and a water absorption pad are sequentially and continuously adhered to the PVC bottom plate. The combination pad is coated with a Raman immune probe (Au-DTNB-Ag-FYL ab) marked with a fentanyl antibody, and the NC membrane is coated with a fentanyl-bovine serum albumin (BSA) conjugate forming a detection line and goat anti-mouse IgG forming a quality control line. The preparation method of the fentanyl surface enhanced Raman spectrum test strip comprises the following steps: preparing nanogold, modifying the surface of the nanogold with Raman signal molecules DTNB, preparing a silver-coated gold composite core shell (Au-DTNB (at) Ag), synthesizing a Raman immune probe, preparing a sample pad, preparing a combination pad, treating the sample pad, and assembling the test strip. The test strip disclosed by the invention has the advantages of high sensitivity, strong specificity, short detection time, on-site operation, low detection cost, simplicity and convenience in operation and the like.

The present invention discloses the use of the CYP3A4*1G gene in the preparation of a product for evaluating the postoperative analgesic effect and dosage prediction of sufentanil combined with butorphanol. The present invention first discovered that the CYP3A4*1G gene polymorphism is one of the genetic factors that cause individual differences in the postoperative analgesic effect and dosage of sufentanil combined with butorphanol. Anesthesiologists can determine the dosage of postoperative analgesics for patients based on these genetic differences, thereby improving patient satisfaction with anesthesia and postoperative analgesia. Therefore, the CYP3A4*1G gene can be used as a marker for evaluating the postoperative analgesic effect and dosage of sufentanil combined with butorphanol. By genotyping CYP3A4*1G, a gene related to postoperative analgesia medication use in patients, guidance can be provided for postoperative analgesic dosage.

The present invention focuses on a surface-enhanced Raman nanoparticle and its application in detecting fentanyls, within the realm of drug safety assessment. The surface-enhanced Raman nanoparticle comprises a noble metal, with gold nanocakes being the preferred choice. The detection method for fentanyls employs the surface-enhanced Raman nanoparticle described in the present invention to conduct Raman detection. This nanoparticle and the associated detection method enable the rapid and non-destructive identification of trace amounts of fentanyls in the target sample, presenting significant potential for application in public safety detection.

The invention provides a fentanyl drug full-cycle circulation traceability management system, and relates to the technical field of data traceability, and the system comprises a batch coding module which is used for distributing a unique batch number for each drug batch according to standardized data, and forming a drug traceability data block; the block chain evidence storage module is used for uploading the drug traceability data blocks to a block chain network through a consensus mechanism for distributed storage, and generating a unique hash value and a timestamp for each data block; and mapping the key space-time attribute of each data block into a circular geometric feature. According to the method, through unique batch coding, block chain distributed evidence storage, geometric feature association verification and hierarchical spherical spatial index construction, safe tamper-proof, association credibility and rapid positioning query of fentanyl drug full-cycle circulation data are realized, and efficient and reliable support is provided for drug full-life-cycle traceability.

An improved formulation may include an enhanced ability relative to its predicates to destroy toxic threats in the form of sporulated bacteria, bacteria protected by biofilms, planktonic bacteria, fungus, viruses, chemical weapons, toxic chemicals including Fentanyl, its analogs, and a whole host of toxic industrial chemicals. The formulation may include a three part product composed of a buffered detergent chemical system, a hydrogen peroxide chemical system and an accelerator system designed to deliver activated peroxygen species when blended together.

The invention relates to a transmission desorption electrospray low-pressure ion mobility spectrometry which comprises a transmission desorption electrospray ion source, an interface electrode and a low-pressure ion migration tube, the interface electrode is a metal sheet electrode with a through hole in the center, and the transmission desorption electrospray ion source is connected with the low-pressure ion migration tube through the interface electrode. The ion mobility spectrometry can realize efficient desorption spray ionization of substances difficult to volatilize in the detection process, the sample detection process is simplified, the working air pressure is lower than the atmospheric pressure, the detection sensitivity can be improved, furthermore, the ion mobility spectrometry is provided with a desolvation area and is combined with desolvation gas, the detection sensitivity can be further improved, and the detection accuracy is improved. High-sensitivity detection of anesthetic drugs such as propofol, etomidate, fentanyl and the like in blood can be realized through transmission-type desorption electrospray and low-pressure ion mobility spectrometry.

The present invention discloses a method for rapid on-site detection of fentanyl analogs using a miniature mass spectrometer, comprising the following steps: (1) selecting a spotting plate; (2) loading a sample: depositing the sample and 3-nitrobenzonitrile solution in acetonitrile on the spotting plate to form a crystalline mixture; (3) carrying out analysis and detection: setting the parameters of the miniature mass spectrometer, placing the crystalline mixture on the spotting plate in close proximity to the inlet of the miniature mass spectrometer, and facilitating the ionization of the crystalline mixture for the analysis and detection of fentanyl analogs. The method for rapid on-site detection of fentanyl analogs using a miniature mass spectrometer provided by the present invention requires no extraction solvent, no voltage, no laser, no gas, and the method is simple, rapid, and suitable for rapid on-site detection of fentanyl analogs.

The present disclosure pertains to a method of detecting an opioid in a sample by (1) determining a butyrylcholinesterase inhibition activity of the sample; and (2) correlating the butyrylcholinesterase inhibition activity of the sample to the presence or absence of opioid in the sample, where no relative inhibition of butyrylcholinesterase activity is correlated to the absence of opioid in the sample, and where a relative inhibition of butyrylcholinesterase activity is correlated to the presence of opioid in the sample. The present disclosure also pertains to assays for detecting opioid in a sample in accordance with the methods of the present disclosure.

Nicotine delivery devices and systems, particularly smoking cessation systems are provided by the present disclosure. Such devices and systems produce a nicotine-containing aerosol for inhalation that mimics smoking. The devices are capable of being adapted to control the amount of nicotine delivered to taper the amount of nicotine delivered to the user over time. Methods for treating patients to stop smoking are also disclosed. The devices, systems and methods can also be used to deliver other drugs disclosed herein, such as opioids (e.g., fentanyl).

This invention belongs to the field of electrochemiluminescence and provides an electrochemiluminescence aptamer sensor for the detection of isobutyryl fentanyl (IBF), its preparation, and its application. An apt@Ni-MOFs / cDNA / Ag-MOGs / SiO2 electrode with electroluminescence and specific recognition properties is modified onto the surface of a glassy carbon electrode (GCE) to form the modified electrode apt@Ni-MOFs / cDNA / Ag-MOGs / SiO2 / GCE. This modified electrode is used as the working electrode, an Ag / AgCl electrode as the reference electrode, and a platinum electrode as the counter electrode. IBF was detected by electrochemiluminescence in a PBS buffer solution containing 0.15 mol / L K2S2O8 at pH 7.4, and the corresponding regression equation was obtained; ΔECL = 2.4 × 10⁻⁶. 4 + 1.6×10 3 ×log C (g / L), correlation coefficient R 2 =0.999, detection limit is 3.3 × 10 –15 g / L. This invention exhibits good selectivity, high sensitivity, and a wide linear range.

The application provides a fentanyl drug full-cycle circulation traceability management system, and relates to the technical field of data traceability, comprising: a batch coding module for assigning a unique batch number to each drug batch according to standardized data to form a drug traceability data block; a blockchain storage module for uploading the drug traceability data block to a blockchain network for distributed storage through a consensus mechanism, generating a unique hash value and a timestamp for each data block; and mapping the key space-time attributes of each data block into a circular geometric feature. The application realizes the secure anti-tampering, correlation credibility and rapid positioning query of fentanyl drug full-cycle circulation data through unique batch coding, blockchain distributed storage, geometric feature correlation verification and hierarchical spherical space indexing construction, and provides efficient and reliable support for drug full-life-cycle traceability.

The invention relates to the technical field of medicine management and control, in particular to a fentanyl medicine full-process tracing control method, which is applied to intelligent management and control equipment, and realizes full-life-cycle closed-loop tracing through six core stages of equipment initialization, warehousing, storage, ex-warehouse, recovery and emergency. In the warehousing stage, double identity verification and double verification recognition assembly cross verification are adopted, and compliance of medicine and personnel information is guaranteed; in the storage stage, real-time monitoring and intelligent regulation and control of temperature and humidity are realized through multi-sensor fusion and an improved moving average algorithm; in the emergency stage, a UPS standby power supply and an emergency lock are adopted for dual guarantee, and medicine accessibility and operation traceability in a power-off scene are ensured; and the traceability data is stored through a block chain technology, and data non-tampering and secure access are realized in combination with three-level permission verification. The normativity, accuracy and reliability of fentanyl drug management and control are improved, and the method is suitable for the requirements of hospitals, drug treatment institutes and other scenes and has important application value.