109 results about "Fentanyl" patented technology

The invention discloses a screening method of fentanyl substances, and belongs to the technical field of detection and identification of fentanyl substances. Comprising the following steps: S1, acquiring m types of fentanyl and fentanyl substance samples, and cracking to obtain characteristic warning fragments; s2, establishing a feature warning fragment database; s3, the warning ion database is imported into TraceFinder software, after a sample to be screened is split, fragments and characteristic warning fragments are deduced through the TraceFinder software according to the fragmentation law and the characteristic theory of each type of fentanyl, and whether the fragments and the characteristic warning fragments are fentanyl substances or not is judged. According to the method, n characteristic warning fragments of fentanyl are obtained after high-resolution mass spectrum pyrolysis characteristics of m known typical fentanyl compounds are obtained, and the characteristic warning fragments are used for constructing a database, so that fentanyl substances can be quickly screened and identified.

The invention discloses an application of a CYP3A4 * 1G gene in preparation of a product for evaluating the postoperative analgesic effect and dosage prediction of sufentanil compounded with butorenol. According to the invention, the gene polymorphism of CYP3A4 * 1G is found to be one of genetic factors causing sufentanil compounded butornori postoperative analgesic effect and dosage use difference individualized difference for the first time, and anesthetists can determine the dosage of analgesic drugs for postoperative patients according to genetic characteristic difference, so that the satisfaction degree of anesthesia and postoperative analgesia of the patients is improved; therefore, the CYP3A4 * 1G gene can be used as a marker for evaluating the postoperative analgesic effect and dosage use of sufentanil compounded with butoenorphan, and detection is carried out through related genes of postoperative analgesic medication of a patient and CYP3A4 * 1G genotyping, so that guidance can be provided for the postoperative analgesic medication dosage of the patient.

Disclosed are an artificial hapten and artificial antigen of fentanyl, and a preparation method and application thereof. The artificial hapten of fentanyl according to the invention has an active group capable of being coupled with a carrier protein, and can be used as an antigenic determinant; and the artificial antigen of fentanyl further prepared can be immunized to obtain an anti-fentanyl antibody with high affinity, high sensitivity and strong specificity, and the antigen-antibody can be used in enzyme-linked immunity, immunochromatography and other technologies.

The invention relates to a hybridoma cell strain capable of secreting dextromethorphan monoclonal antibody and application of the hybridoma cell strain, and belongs to the technical field of immunodetection. The monoclonal antibody secreted by the hybridoma cell strain disclosed by the invention has good sensitivity and specificity on dextromethorphan, wherein the IC50 value on the dextromethorphan is 0.162 ng / mL. The monoclonal antibody provided by the invention has no cross reaction on structural analogues of dextromethorphan, such as fentanyl, thilazine, papaverine, morphine and medetomidine, and has good specificity, so that the dextromethorphan with low concentration can be accurately detected.

According to the fisetin nanoparticle preparation method, the fisetin nanoparticle product and the application, the synergistic effect of amino acid catalysis and a microwave or ultrasonic energy field is matched with mixing self-assembly and subsequent spray drying forming under the acidic condition, on one hand, the traditional Maillard reaction period is greatly shortened, and energy consumption is reduced; on one hand, the whole technological process of wall material preparation and active ingredient loading is simplified, the large-scale production requirement is met, on the other hand, the fisetin encapsulation effect and the nanoparticle structure stability are improved, the defects that fisetin is poor in water solubility and low in bioavailability are overcome, meanwhile, it is guaranteed that the nanoparticle product quality is uniform, the technology efficiency and the product performance superiority are considered, and the method is suitable for industrial production. The core pain points of low efficiency, poor drug loading effect and insufficient product stability of the existing traditional process are effectively overcome.

Nicotine delivery devices and systems, particularly smoking cessation systems are provided by the present disclosure. Such devices and systems produce a nicotine-containing aerosol for inhalation that mimics smoking. The devices are capable of being adapted to control the amount of nicotine delivered to taper the amount of nicotine delivered to the user over time. Methods for treating patients to stop smoking are also disclosed. The devices, systems and methods can also be used to deliver other drugs disclosed herein, such as opioids (e.g., fentanyl).

A drug resistant film is provided. The drug resistant film includes a drug contact sealing layer, an aluminum foil layer, a biaxially oriented polyamide layer, and a paper layer. The drug contact layer is configured to contact a drug, such as lidocaine, nicotine, or fentanyl. The aluminum foil layer is affixed to the drug contact sealing layer via a first lamination adhesive. The biaxially oriented polyamide layer is affixed to the aluminum foil layer via a second lamination adhesive. The paper layer is affixed to the biaxially orientated polyamide layer via a third lamination adhesive. According to an example, the drug contact sealing layer comprises an extruded monolayer of COC, EVOH, or PETG. According to an example, the drug contact sealing layer is a coextruded layer comprising a plurality of sublayers.

1. Name of the product of this design: Smart Cabinet for Fentanyl Drugs (FTNG‑T‑DS01). 2. Purpose of this design product: used for storing items. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: main view.

1. Name of the product of this design: Smart Cabinet for Fentanyl Drugs (FTNG‑L‑DS02). 2. Purpose of this design product: used for storing items. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: main view.

The invention relates to the technical field of detection and identification of fentanyl substances, and discloses a selective quantitative detection method of fentanyl. According to the method, a differential pulse voltammetry (DPV) is used for making a linear relation diagram of a potassium ferricyanide peak current and fentanyl solutions with different concentrations to obtain a standard working curve, a linear equation is obtained through the standard curve, and the detection limit is 1.0 * 10 <-12 > mol.L <-1 >; the molecularly imprinted membrane modified electrode prepared by the invention is used for measuring the peak current of a potassium ferricyanide solution, so that fentanyl molecules can be indirectly and quantitatively analyzed and measured. The method is characterized in that a fentanyl molecularly imprinted membrane is electrically polymerized on the surface of a glassy carbon electrode, m-phenylenediamine is used as a functional monomer, and the selectivity and sensitivity of an electrochemical method for detecting fentanyl are improved. Meanwhile, by taking an adsorption pulse stripping voltammetry (DPASV) as a detection technology, a method capable of rapidly detecting fentanyl molecules in the presence of various drugs is established. The molecularly imprinted membrane electrode disclosed by the invention is simple to prepare, quick in response and good in selectivity and reproducibility, and can be repeatedly used for more than five times.

The invention provides a fentanyl transdermal patch and a preparation method thereof. The fentanyl transdermal patch comprises a backing layer, a drug-containing adhesive layer and a release layer, the drug-containing adhesive layer comprises fentanyl or pharmaceutically acceptable salts thereof, and the mass percentage of 1-(2-phenethyl)-4-(N-phenylpropanamide)-piperidine-N-oxide in the drug-containing adhesive layer is less than 0.5% based on the total mass of the drug-containing adhesive layer; the method comprises the step of annealing a semi-finished product of the fentanyl transdermal patch to obtain the fentanyl transdermal patch. The method is easy to operate, the content of 1-(2-phenethyl)-4-(N-phenylpropanamide)-piperidine-N-oxide in the fentanyl transdermal patch is smaller than 0.5%, related substances of the fentanyl transdermal patch meet the quality standard, and the fentanyl transdermal patch has the advantages of being low in impurity content, high in stability and the like.

Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.

1. The name of the design product: fentanyl drugs special intelligent cabinet (table type). 2. The use of the design product: intelligent cabinet for managing and monitoring medical drugs. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

This invention discloses a method and application for detecting fentanyl and toluenethiazide using a microfluidic chip coupled with ion mobility spectrometry (IMS), belonging to the field of analytical chemistry. The method utilizes a microfluidic chip platform coupled with IMS for detection, specifically including the following steps: using a dual-channel microfluidic chip platform filled with adsorbent material, fentanyl and toluenethiazide are enriched in the sample to be tested; then, IMS is used to detect the enriched fentanyl and toluenethiazide in the sample. The detection method provided by this invention has high repeatability, minimizes operator exposure to drugs throughout the process, and greatly improves the accuracy and detection efficiency. Furthermore, the detection method provided by this invention has a short testing time, high sensitivity, and is automated and environmentally friendly, enabling rapid screening of fentanyl and toluenethiazide in multiple matrices.

The present disclosure relates to a method of treatment or prophylaxis of a preterm infant by administering intravenously a therapeutic amount of a composition comprising IGF-1 and IBGBP-3 in combination with a therapy selected from the group comprising: caffeine, fentanyl, fluconazole, gentamicin, insulin, midazolam, morphine, low dose norepinephrine, vancomycin concentrations of 5 mg / ml or less, parenteral nutrition (or a composition for the same use) and combinations thereof.

1. The name of the design product: fentanyl drugs special intelligent cabinet (single-sided). 2. The use of the design product: intelligent cabinet for managing and monitoring medical drugs. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The present invention relates to a novel lateral flow assay method and devices using a container separate from the strip to contain the dried nanoparticle conjugate. The method and devices can significantly improve the sensitivity of the lateral flow assay. It can be used in both sandwich and competitive immunoassays or non-immunological assays in the lateral flow format. In specific embodiments, the methods and devices are advantageous for identifying fentanyl and analogs in a sample.

This invention relates to the field of medical data processing technology, and discloses a method, system, device, and medium for calculating the synergistic control rate of drug infusion. The invention acquires the patient's real-time bispectral index (BSE) and determines its deviation from a preset target range. A control algorithm is then used to calculate the required total effect intensity adjustment. Based on a preset fixed ratio of propofol and remifentanil effect-site concentrations, the total effect intensity adjustment is allocated to the target effect-site concentrations of each drug. Finally, the target infusion rates of propofol and remifentanil are calculated backward using the Schnider and Minto models, respectively. This invention achieves synergistic closed-loop control of sedative and analgesic drugs based on a single BIS feedback, solving the clinical problem of unquantifiable analgesia control, ensuring a dynamic balance between sedation and analgesia, and incorporating a built-in safety verification mechanism. This significantly improves the accuracy, stability, and safety of anesthesia depth control, while reducing clinical workload.

The invention discloses a label-free ratio fluorescence sensor and a method for detecting fentanyl substances, and belongs to the field of analysis and detection.The sensor comprises a recognition element, the recognition element comprises six kinds of guanine-rich DNA aptamers and a signal conversion element, and the signal conversion element comprises a fluorescent dye. According to the invention, a plurality of fentanyl analogues can be rapidly detected.

The invention relates to a dosing regimen for sedation with the fast-acting benzodiazepine CNS 7056 in combination with an opioid, in particular fentanyl, whereas CNS 7056 is given in a dose of 2 to 20 mg, preferably between 4 and 9 mg and most preferably between 5 and 8 mg.

Biosynthetic melanin can capture fentanyl from aqueous environments. The captured fentanyl can be released by introducing the fentanyl-bound melanin to an acidic environment. In this way, fentanyl can capture melanin for subsequent detection / analysis, in addition to operating to remove fentanyl for decontamination.

The invention is suitable for the technical field of medical instruments, and provides an infusion analgesia patch which comprises a backing layer, an inner cavity is formed in the backing layer, a hardening layer is arranged at the upper end of the backing layer, the hardening layer is arranged above the inner cavity, the hardening layer is used for blocking an upper end opening of the inner cavity, the hardening layer is fixedly connected to the backing layer, and materials on the sides of the inner cavity are subjected to hardening treatment. The inner cavity is internally provided with an isolating layer, the isolating layer is fixedly connected with the hardened inner side face of the inner cavity, the inner cavity is internally provided with a controlled release film, fentanyl is released through the controlled release film and is absorbed by skin, fentanyl is combined with an opioid receptor in a body, transmission and perception of pain signals are inhibited, and therefore the analgesic effect is achieved. The puncture microneedle penetrates through the controlled release membrane and the cotton cloth layer and can puncture the cuticle of the skin in a minimally invasive mode, and a reversible microchannel is formed on the surface of the skin. The micro-channels provide a direct skin entering path for medicine molecules, so that the transdermal efficiency is greatly improved.

Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.

1. The name of the product of this design: Smart cabinet for drugs (Fentanyl drugs NB03). 2. Purpose of this design product: This design product is an intelligent cabinet used to manage and monitor medical drugs. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the key points of the design: main view.

The invention relates to a pharmaceutical composition for intraoperative brain protection in shoulder arthroscopy surgery. The pharmaceutical composition comprises midazolam, propofol, sufentanil, succinylcholine and atracurium besylate. According to the invention, rScO2 can be improved, the risk of cerebrovascular events can be reduced, but no obvious influence is generated on the circulation stability in the operation of a patient, the postoperative cognitive impairment and the like.

Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.

The invention discloses a detection method and a preparation method of a fentanyl surface enhanced Raman spectroscopy test strip which are rapid, sensitive and simple and convenient to operate. The test strip comprises a sample pad, a combination pad, an NC membrane, a water absorption pad and a PVC bottom plate. A sample pad, a combination pad, an NC (nitrocellulose) membrane and a water absorption pad are sequentially and continuously adhered to the PVC bottom plate. The combination pad is coated with a Raman immune probe (Au-DTNB-Ag-FYL ab) marked with a fentanyl antibody, and the NC membrane is coated with a fentanyl-bovine serum albumin (BSA) conjugate forming a detection line and goat anti-mouse IgG forming a quality control line. The preparation method of the fentanyl surface enhanced Raman spectrum test strip comprises the following steps: preparing nanogold, modifying the surface of the nanogold with Raman signal molecules DTNB, preparing a silver-coated gold composite core shell (Au-DTNB (at) Ag), synthesizing a Raman immune probe, preparing a sample pad, preparing a combination pad, treating the sample pad, and assembling the test strip. The test strip disclosed by the invention has the advantages of high sensitivity, strong specificity, short detection time, on-site operation, low detection cost, simplicity and convenience in operation and the like.

The present invention discloses the use of the CYP3A4*1G gene in the preparation of a product for evaluating the postoperative analgesic effect and dosage prediction of sufentanil combined with butorphanol. The present invention first discovered that the CYP3A4*1G gene polymorphism is one of the genetic factors that cause individual differences in the postoperative analgesic effect and dosage of sufentanil combined with butorphanol. Anesthesiologists can determine the dosage of postoperative analgesics for patients based on these genetic differences, thereby improving patient satisfaction with anesthesia and postoperative analgesia. Therefore, the CYP3A4*1G gene can be used as a marker for evaluating the postoperative analgesic effect and dosage of sufentanil combined with butorphanol. By genotyping CYP3A4*1G, a gene related to postoperative analgesia medication use in patients, guidance can be provided for postoperative analgesic dosage.

The present invention focuses on a surface-enhanced Raman nanoparticle and its application in detecting fentanyls, within the realm of drug safety assessment. The surface-enhanced Raman nanoparticle comprises a noble metal, with gold nanocakes being the preferred choice. The detection method for fentanyls employs the surface-enhanced Raman nanoparticle described in the present invention to conduct Raman detection. This nanoparticle and the associated detection method enable the rapid and non-destructive identification of trace amounts of fentanyls in the target sample, presenting significant potential for application in public safety detection.

A method for providing a slide, wherein the method comprises the steps that: i) a base layer that is water and / or oxygen resistant is provided; ii) a layer comprising a bonding layer and a contact layer is coextruded to provide a coextruded layer; iii) the coextrusion layer is coated onto the base layer; iv) the coextruded layer coated onto the base layer is allowed to adhere to obtain a film resistant to aggressive chemicals, wherein the aggressive chemical is nicotine, fentanyl, lidocaine or rivastigmine, wherein the film comprises the coextruded layer formed from the bonding layer and the contact layer, which is coated onto the base layer, the bonding layer comprising at least one layer; and wherein the contact layer comprises a polymer having a RED value towards an aggressive chemical, namely nicotine, fentanyl, lidocaine or rivastigmine, based on the Hansen's solubility parameter (HSP) of > 0.8, more preferably a RED value in the range of 0.8 to 10, more preferably 0.8 to 5 and most preferably 1 to 2.