43 results about "Sedation" patented technology

The invention relates to the technical field of intelligent anesthesia precise regulation and control, and discloses an anesthetic dosage optimization method based on artificial intelligence. According to the method, a dynamic treatment interval is constructed, and the boundary of the dynamic treatment interval is adaptively adjusted according to the real-time sedation depth and the nociceptive stimulation level. And in the interval, performing pattern recognition on the continuous electroencephalogram signals and the hemodynamic parameters, and marking abnormal events deviating from a standard anesthesia state. And establishing a correlation network of the drug effect chamber concentration and the abnormal events, and generating a virtual drug response curve for predicting the trend of the abnormal events under different doses. Whether dose strategy reconstruction is started or not is determined by comparing the goodness of fit between the prediction curve and the actual physiological trajectory. During reconstruction, contribution weights of historical drug infusion points to abnormal events are backtracked and analyzed, and adjustment coefficients are distributed and integrated into a new infusion sequence. According to the invention, individualization and self-adaptive optimization of anesthesia administration are realized, and the accuracy and safety of anesthesia depth control are improved.

Methods and compositions are provided for treating individuals exhibiting opioid withdrawal symptoms with opioid, benzodiazepine and other drugs of abuse by administering an opioid receptor antagonist agent together with a respiratory stimulant to reverse the effects of opioid withdrawal symptoms, including respiratory depression, sedation, and hypotension. Methods and compositions are also provided for treating stimulant overdose with a benzodiazepine and beta-adrenergic blocking agent. Methods and compositions are also provided for treating concurrent stimulant and opioid overdose comprising administering to a patient in need thereof a benzodiazepine and an opioid antagonist. Methods and compositions are also provided for treating individuals exhibiting opioid withdrawal symptoms or prophy tactically treating individuals for opioid withdrawal symptoms from opioid, benzodiazepine and other drugs of abuse by administering an opioid receptor antagonist agent together with a respiratory stimulant to reverse the effects of withdrawal, including respiratory depression, sedation, and hypotension.

This disclosure relates to systems and methods for monitoring sedated patients that are receiving supplemental oxygen flows. A method of monitoring a patient's breathing while sedated includes identifying an end expiratory pause in the patient's breathing pattern and obtaining a first respiratory signal corresponding to a nasal pressure of a patient. The method may also include delivering a pulse of high-flow oxygen during the end expiratory pause at a rate of about 30 liters-per-minute (L / min) and delivering the pulse of high-flow oxygen during the end expiratory pause for less than 0.5 seconds. The method may further include measuring a peak nasal pressure and a peak oxygen flow and synthesizing a second respiratory signal. The second respiratory signal may correspond to the peak nasal pressure and the peak oxygen flow, and may be normalized for the patient. The method may additionally include determining the patient's breathing pattern, rate, or frequency.

This invention provides a novel GABA structure with better efficacy, reduced side effects, and greater safety for clinical use. A This invention relates to receptor agonists, specifically a phenol derivative, its preparation method, and its use in the central nervous system. The phenol derivative provided by this invention offers more and better drug options for inducing or maintaining anesthesia in animals or humans, promoting sedation and hypnosis, and treating and / or preventing anxiety, nausea, vomiting, migraines, seizures, epilepsy, neurodegenerative diseases, and other central nervous system-related disorders.

The invention discloses a critical patient rehabilitation evaluation system based on artificial intelligence, particularly relates to the technical field of medical information and intelligent rehabilitation evaluation, and is used for solving the problems that in an intensive care unit, multi-source data are not synchronous, nursing and treatment events are often caused, sedation and ventilation fluctuation pollution is caused, and the problem of serious illness is solved. And thus, the problem of distortion in judgment of which level cannot move nowadays and can move to can be solved. A unified time base is established through three types of anchor points of nursing, body position and cardiopulmonary rhythm, passivity and autonomy are judged in an influence time period, and the passivity is deducted and reserved; and then sedation, circulation, respiratory support and medication are compiled into safety budget with delay, linkage evidence quantity and uncertainty adjustment release rhythm, and degradation and rollback are triggered by an anti-fact track of margin segmentation, so that an executable prescription of'activity, reachable grade and reason 'is output beside a bed, event pollution and physiological fluctuation are inhibited, and the aim of preventing and treating the patient is fulfilled. And maloperation and missed operation are reduced.

Sedation device. The sedation device includes: a housing; the housing having a ventilator chamber and a juxtaposed vaporizer chamber; a filter installed between the ventilator chamber and the vaporizer chamber, forming a common breathable partition wall; the ventilator chamber having an inlet; the vaporizer chamber having an outlet for connection to a patient's breathing tube; and an vaporizer installed within the vaporizer chamber, wherein the inlet is positioned to guide air through the surface of the filter in the ventilator chamber and has an air guide ramp angled relative to the inlet and flared outward away from the inlet to guide incoming air inward from the inlet toward the filter and outward from the inlet through the surface of the filter; an elongated air distribution fin is installed on the outer wall of the ventilator chamber, aligned with the inlet at the inner end of the air guide ramp and extending away from the air guide ramp; the air distribution fin is perpendicular to the outer wall and located at the center of the outer wall, aligned with the inlet; the air distribution fin has a sharp leading edge facing the inlet.

Pharmaceutical combinations of etomidate derivatives and propofol and pharmaceutical compositions thereof for use in anesthesia, sedation and / or hypnosis of animals or humans. The pharmaceutical composition of the etomidate derivative and the propofol or the pharmaceutical composition of the etomidate derivative and the propofol shows an excellent synergistic effect compared with independent administration and combined administration.

A method for operating a hemorrhoid treatment device includes coupling a hemorrhoid treatment device to a computing device with a cable. A probe electrode is coupled to the hemorrhoid treatment device. A grounding pad is placed in contact with a patient to be treated for hemorrhoids. The grounding pad is to be coupled to the hemorrhoid treatment device. Anesthesia or sedation is provided to patient. The method includes setting a level of current to be applied by the hemorrhoid treatment device, with the level of current exceeding a level that causes discomfort to the patient. The hemorrhoid treatment device is operated to deliver an output voltage to the probe electrode, with the probe electrode to contact the hemorrhoid being treated, and adjust the output voltage to compensate for fluctuations in body resistance of the patient so that the set level of current being delivered to the hemorrhoid is consistent.

Methods of sedation using active peptides are provided, as are compositions comprising the peptides and uses of the peptides.

Described herein is a method of administering injectable cetirizine or levocetirizine to treat acute urticaria, with or without concomitant angioedema, without life-threatening airway swelling by intravenously injecting a human patient within minutes to hours of developing acute urticaria in an emergency department or clinic with a therapeutically effective amount of an injectable cetirizine or levocetirizine composition. In the method, the injectable cetirizine or levocetirizine is the only treatment administered in the emergency department or clinic. The method can include determining, by the patient, a patient rated pruritus severity score at a 1 hour assessment, and optionally at a 2 hours assessment, and a physician discharging the human patient after 1.7±0.9 hours in the emergency department or clinic, wherein the human patient has a patient rated pruritus severity score reduction of at least 1 unit and baseline sedation at the time of discharge.

1. Name of the product in this design: Oropharyngeal ventilation tube. 2. Purpose of this design: To provide comfortable diagnosis and treatment for painless endoscopy such as painless gastroscopy, colonoscopy, and bronchoscopy, as well as an airway management tool during sedation and anesthesia for painless egg retrieval, superficial or minor surgeries. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the key design points: Design 1 3D view. 5. Design 1 is designated as the basic design.

The invention provides a heterocyclic compound and a pharmaceutical composition and application thereof, and belongs to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

The invention provides a limb fixing frame for the intensive care medicine department, and relates to the field of medical instruments, and the limb fixing frame is characterized by comprising a base, an angle adjusting mechanism and a limb lifting mechanism; the angle adjusting mechanism is installed on the base, and the limb lifting mechanism is installed on the angle adjusting mechanism. The fixing device has the advantages that by arranging the angle adjusting mechanism and the limb lifting mechanism with the buffering function, the problem that a patient is forced to keep a stiff posture due to the fact that a fixing device in the prior art is lack of angle adjustment is solved, the limb angle can be flexibly adjusted according to treatment requirements, stability is kept through a self-locking structure, and the fixing device is convenient to use. Muscle fatigue, spasm and ankylosis can be effectively prevented; meanwhile, by means of the buffering design of the flexible supporting plate and the pressure spring, the comfort degree is remarkably improved, the dysphoria and contradictive emotion of the patient are relieved, sedation management and early rehabilitation of the critical patient are facilitated, and it is guaranteed that treatment and nursing are conducted smoothly.

This invention provides a treatment for patients with developmental and epileptic encephalopathy (DEE) that addresses behavioral problems in addition to seizures, without causing undesirable side effects such as somnolence, lethargy, withdrawal, and sedation. [Solution] A method is provided for treating behavioral problems and seizures in a subject having DEE, comprising administering an effective amount of cannabidiol (CBD) transdermally to the subject, wherein the behavioral problems are treated in the subject.

The invention relates to the crossing field of anesthetic medicine and artificial intelligence, and discloses a remazolam anesthetic dosage AI prediction system, which comprises a data acquisition module, a data processing module, a data processing module and a data processing module, and is characterized in that the data acquisition module is used for acquiring multi-dimensional clinical data of a target patient; the feature engineering module is used for generating a standardized feature data set based on the multi-dimensional clinical data; the improved StochDiff time sequence prediction module is used for outputting an initial individualized drug delivery scheme of the remazolam and prediction distribution of vital signs and sedation depth of a patient after drug delivery through a pre-trained improved StochDiff time sequence prediction model based on the standardized feature data set; the dose dynamic correction module is used for carrying out online dynamic correction on the initial individualized administration scheme based on patient data collected in real time in an operation and updating administration parameters in real time; and the safety early warning module is used for realizing pre-grading early warning of adverse anesthesia events based on a model prediction result and real-time data in an operation. Therefore, individualized precise administration and anesthesia safety guarantee are realized.

The present application discloses a kind of drug composition treatment psychotropic disease and the use in pruritus. Specifically, the present application discloses the use of compound beta01 with the following formula structure, or its pharmaceutically acceptable salt and antipsychotic drug composition for preparing the drug for treating psychotropic disease and pruritus.The compound beta01 provided by the present application will not cause side effects such as anxiety and sedation, and is particularly friendly to the population who suffer from anxiety and sedation caused by taking drugs.

The invention relates to the technical field of research and development of original drugs, and discloses a sleep-aiding traditional Chinese medicine stir-fried and scorched incense and a preparation method of the sleep-aiding traditional Chinese medicine stir-fried and scorched incense. 15 to 30 parts of brown malt; 5 to 15 parts of fructus momordicae; 3-8 parts of an adhesive; and 40 to 150 parts of purified water. Long-term insomnia obviously affects health, the risk of cardiovascular diseases is easily increased, and many problems such as metabolic disorder, cognitive impairment and immunity decline are caused, benzodiazepine drugs are commonly used for sedation and hypnosis, and tolerance and dependency are easily generated after long-term use of the benzodiazepine drugs. According to the invention, the scorched fragrance emitted by the traditional Chinese medicine fried to be scorched is developed into the sleep-aiding incense, the scorched fragrance of the traditional Chinese medicine fried to be scorched is creatively prepared, collected and applied by adopting a low-temperature drying and incense nourishing method, and meanwhile, the health management APP is matched to strengthen the self sleep management consciousness of a patient through the functions of incense reminding, symptom recording, voice guidance and the like, so that the sleep-aiding effect of the patient is improved. Identification and mechanism research of scorch aroma substances are carried out, and clinical random control tests and animal model experiments are combined.

The invention discloses a closed-loop controlled intelligent sedation depth and delirium detector, and relates to the field of clinical assistance, the closed-loop controlled intelligent sedation depth and delirium detector comprises a head-mounted mechanism, the head-mounted mechanism comprises a cap body, and a semi-arc ring is arranged below the cap body; according to the intelligent sedation depth and delirium detector, the electrode plates are pre-arranged in the containing groove and then are led out in order through the signal line, traditional scattered pasting is avoided, and the wearing efficiency and the positioning consistency are improved; the supporting mechanism realizes rapid height adjustment and locking by virtue of a vertical rod, a limiting rod, a limiting hole and a reset spring, and a camera can be accurately mounted and firmly fixed without a tool in cooperation with a rapid clamping structure consisting of an arc-shaped clamp, a spring damper and a deflector rod and a horizontal fine adjustment capability provided by a magnetic block and an adaptive groove; the electrodes and the camera share the same head-mounted platform, and the spatial relationship of the electrodes and the camera is fixed, so that the relative position can be kept stable even if the patient slightly moves.

The present application relates to a painless gastrointestinal endoscopy adaptive dosing method and system based on multi-source physiological signal fusion, belonging to the field of medical artificial intelligence and automatic control technology, through real-time acquisition and fusion of patient's electroencephalogram, electrocardiogram, skin electricity and blood oxygen saturation and other multi-modal physiological signals, using artificial intelligence model to deeply extract features and quantitatively evaluate the sedation- analgesia level of the patient, relying on the pharmacokinetics- pharmacodynamics model constructed by the big data platform, dynamically predicting the drug effect according to the individual characteristics and real-time state of the patient, and automatically and accurately adjusting the infusion rate of anesthetic drugs through a closed-loop control algorithm, realizing personalized and adaptive dosing, setting up an independent safety monitoring mechanism, and real-time intervention on risk events such as respiratory depression. The present application can effectively solve the problems of traditional anesthesia relying on artificial experience, single parameter monitoring being not comprehensive and lacking individualized dynamic adjustment, and significantly improve the safety, comfort and medical efficiency of painless gastrointestinal endoscopy.

This invention relates to the field of medical device technology and discloses a closed-loop control method for a personalized acupoint stimulation system, comprising the following steps: S1, patient registration and personalized protective gear preparation stage; S2, physician prescription generation stage; S3, prescription instruction issuance and stimulation execution stage; S4, real-time treatment data acquisition and feedback stage; S5, physician efficacy evaluation and syndrome differentiation review stage; S6, prescription dynamic optimization and closed-loop iteration stage. This invention, through customized protective gear preparation technology and built-in vibration isolation structure design, achieves alignment between the stimulation unit and the target acupoint, avoiding mutual interference during the operation of multiple stimulation units, and improving the accuracy and independence of acupoint stimulation. Simultaneously, through multi-channel independent control and refined collaborative timing design, it can fully realize the synergistic treatment logic of TCM acupoint combinations and the digital simulation of traditional tonification and sedation techniques, fully aligning with the core diagnostic and treatment concepts of TCM syndrome differentiation and treatment.

The invention relates to an application designed to be used in general anesthesia and sedation applications, which can use multiple parameters and adjust medication and anesthetic gas dosages and the amount of fluid according to these parameters.

The invention relates to essence with soothing, repairing and anti-inflammatory effects and a preparation method thereof, and belongs to the technical field of cosmetics. The essence is prepared from the following components in percentage by weight: 0.001 percent to 5.0 percent of a kava-pink red plum compound, 0.05 percent to 1.0 percent of dipotassium glycyrrhizinate, 0.5 percent to 5.0 percent of alpha-glucan oligosaccharide, 0.1 percent to 2.0 percent of bionic barrier lipid, 0.5 percent to 3.0 percent of an emulsifier, 3.0 percent to 15.0 percent of a humectant and the balance of water. The kava-rubus parvifolius compound is a derivative formed by covalently linking kava lactone and a flavonoid component through an ester bond or a carbonate bond, and the compound hydrolyzes and releases active molecules under the action of dermatase, so that precise synergistic effect is realized. The essence is suitable for relieving skin irritation and repairing skin barriers through the synergistic effect of four mechanisms of nerve calming, biochemical anti-inflammation, physical barrier repairing and micro-ecological regulation.

The invention relates to the technical field of skin care diagnosis and treatment, and discloses a low-light linkage middle embryo accurate diagnosis and treatment system which comprises an MTS electric micro-needle module, a water-light injection module, a sedation management module, a three-day professional product auxiliary module and a three-day regeneration management module, and the low-light linkage middle embryo accurate diagnosis and treatment system comprises the following method steps: an MTS electric micro-needle module, a water-light injection module, a sedation management module, a three-day professional product auxiliary module and a three-day regeneration management module; and an efficient skin management scheme is provided by utilizing reversible physical minimally invasive surgery under the conditions of no huge pain and no obvious wound surface. Through the combined operation of the MTS electric microneedle and the water-light injection beauty treatment, the absorption of the skin to the liquid medicine from epidermal strength (MTS) to dermis complete administration (water-light) can be called full-level absorption of the liquid medicine, so that the skin is comprehensively improved from top to bottom, the vertical damage regeneration makes a new vomit to the skin, the peak superposition is realized, the effect is doubled, and the effect is improved. And the mesoderm is improved by utilizing the combined operation of the MTS electric microneedle and water-light injection, so that the essence of the skin is improved.

This invention belongs to the field of pharmaceutical technology, specifically relating to soluble gabapentin microneedle patches, their preparation methods, and applications. The microneedles provided by this invention are prepared by negative pressure centrifugation using gabapentin, hyaluronic acid, anesthetic, and water in a specific ratio. These microneedles can penetrate the stratum corneum of the skin, rapidly dissolving and releasing the drug within 10 minutes, effectively solving the problems of slow onset and low bioavailability in traditional drug administration. They also possess excellent mechanical strength and safety, with no skin irritation or organ toxicity, and are specifically designed to relieve or treat symptoms of stress, anxiety, fear, and epilepsy, providing sedation, adjunctive analgesia, and emotional calming effects, significantly improving the convenience and compliance of drug administration.

The utility model provides a disposable laughing gas inhalation anesthesia sedation pipeline which comprises a gas inlet pipeline, an inhaler and a gas exhaust hole, the gas inlet pipeline is communicated with the inhaler, the gas exhaust hole is formed in the inhaler, the gas inlet pipeline is communicated with a gas supply pipeline of a laughing gas machine, and the inhaler comprises a lip tube and a nasal plug. The lip tube is communicated with the air inlet pipeline, the left end and the right end of the lip tube are respectively provided with a first air channel, a second air channel is arranged in the nose plug, the nose plug is arranged on the lip tube, and the first air channels are communicated with the second air channel in a matched mode. The inhaler with a novel structure is formed by the lip tube and the nasal plug, and compared with a nasal mask, the inhaler has the advantages that the size is small, the nose of a patient cannot be covered, and oral operation of medical staff cannot be affected; on the other hand, aversion of the patient cannot be caused; and thirdly, the nose plug is in the shape of an elliptical table, so that the nose plug can meet the requirements of patients with different nostril sizes, and a plurality of annular arc-shaped bulges are arranged on the inclined surface of the elliptical table, so that the nose plug can be better attached to the nasal cavity of the patient, gas escape is avoided or reduced, and reduction of the sedation effect is avoided.

The application relates to the technical field of intelligent anesthesia precise regulation and control, and discloses an anesthetic drug dose optimization method based on artificial intelligence. The method constructs a dynamic treatment interval, the boundary of which is self-adaptively adjusted according to real-time sedation depth and nociceptive stimulation level. Within the interval, pattern recognition is performed on continuous electroencephalogram signals and hemodynamic parameters to mark abnormal events deviating from the standard anesthesia state. An association network is established between drug effect chamber concentration and abnormal events, and a virtual drug response curve is generated to predict the trend of abnormal events under different doses. By comparing the coincidence degree of the predicted curve and the actual physiological trajectory, it is determined whether to start dose strategy reconstruction. When reconstruction is performed, the historical drug infusion points are analyzed to obtain the contribution weight of the abnormal events, an adjustment coefficient is allocated, and a new infusion sequence is integrated. The application realizes individualization and adaptive optimization of anesthetic administration, and improves the precision and safety of anesthesia depth control.

The invention relates to the technical field of tumor nursing, in particular to a method for improving sleep of a breast cancer patient through combination of aroma regulation and abdominal arrest respiration, which comprises the following four links: S1, mixing three essential oils, adding gamma-aminobutyric acid, stirring for reaction, adding beta-cyclodextrin to prepare an inclusion compound, cooling, adding traditional Chinese medicine extract and purified water, ultrasonically dispersing, filtering, preserving heat and regulating pH to obtain an essential oil solution; standing to obtain a compound preparation; s2, adjusting the temperature, humidity, light and noise of a ward two days before radiotherapy, debugging an aromatherapy machine, and adding a preparation for preheating; s3, performing staged aromatherapy 1.5 hours before sleep, and synchronously guiding abdominal arrest breathing; and S4, inspecting and monitoring the heart rate every 15 minutes, evaluating and adjusting every 7 days, and continuing to 1 week after radiotherapy. According to the method, synergistic sleep aiding of chemical sedation and traditional Chinese medicine conditioning is achieved through a compound preparation, negative emotion is relieved through staged aromatherapy and respiratory training, and safety is improved through personalized evaluation; the traditional Chinese medicine composition is free of medicine dependence, improves sleep and emotion, adapts to the radiotherapy period and is high in patient compliance.

The application provides a patient score and sedative pump regulation system and method based on video multidimensional feature extraction, and relates to the technical field of sedative management of ICU critical patients. The application only needs an ordinary RGB camera, does not need to paste electrodes or sensors, has low equipment cost, and does not affect nursing operation; covers 4 parts of eyes / hands / feet / heads x 9-dimensional features, and is more accurate than single features based on SAM3 mask level tracking; threshold values are obtained from clinical data statistics instead of being set by human experience, and have higher repeatability and objectivity; a complete closed loop of "video score -> target comparison -> sedative pump regulation" is realized, manual intervention is reduced, and regulation accuracy and timeliness are improved; a three-level safety protection mechanism (excessive wakefulness alarm, dose non-standard alarm, emergency response) ensures clinical safety.

The invention relates to a visual nasopharynx-imbedded airway / tracheal catheter system which comprises an airway catheter internally provided with an oxygen supply airway and a laryngeal anesthesia tube imbedded in the pharynx of a patient through the oxygen supply airway, a jacking air bag is arranged on one side of the front end of the laryngeal anesthesia tube, a local anesthetic administration channel is arranged in the laryngeal anesthesia tube, and the local anesthetic administration channel is communicated with the airway catheter. A camera is arranged at the front end of the ventilation catheter, an inclined plane is arranged at the front end of the ventilation catheter, the normal direction of the inclined plane is opposite to the epiglottis direction, and an air bag is arranged at the front end of the ventilation catheter. The ventilation catheter is matched with the laryngeal anesthesia tube with the jacking cuff to penetrate into the epiglottis from the nasal cavity of a patient, the tip is guided by the camera to accurately reach and be maintained below the epiglottis and above the glottis, the soft palate, the tongue and the epiglottis can be supported, upper respiratory tract obstruction caused by collapse of the three structures due to sedation or diseases is effectively avoided, and the operation is simple and convenient. The respiratory tract smoothness is maintained.

The invention discloses a ginsenoside-containing flash release agent as well as a preparation method and application thereof. The flash release agent is prepared from red ginseng, dwarf lilyturf tuber, Chinese magnoliavine fruit and specific auxiliary materials, and does not contain any sweetening agent or flavoring agent. The preparation method comprises the steps of superfine grinding, clathration and taste masking and direct tabletting. According to the invention, by optimizing the ratio of auxiliary materials and a tabletting process, the preparation is rapidly disintegrated within 3 seconds under the tongue, active ingredients are directly absorbed by sublingual mucous membrane, the first-pass effect is effectively avoided, and the preparation rapidly takes effect within 3 minutes; meanwhile, a sugar-free formula and a cyclodextrin inclusion technology are adopted, so that the beverage tastes good and is suitable for diabetics. The preparation method is simple and convenient in process and excellent in stability, and can be used for preparing medicines or health-care products for improving learning and memory, relieving fatigue or assisting sedation.