The invention provides a multi-element synergic plugging agent and application thereof. The multi-element synergic plugging agent comprises the component 1 or the component 2, wherein the component 1 comprises the following components in parts by weight: 40-50 parts of rigid particles, 15-20 parts of a flexible material, 15-20 parts of an ultrafine filling material, and 15-20 parts of an expansive type polymer: the component 2 comprises the following components in parts by weight: 50-70 parts of rigid particles, 10-25 parts of a flexible material, 10-25 parts of an ultrafine filling material, and 10-30 parts of an expansive type polymer. The multi-element synergic plugging agent disclosed by the invention combines the rigid material with the flexible material, incorporates the elastoplasticity, fully utilizes the synergistic function of the materials, can effectively plug the cracks with different widths, has the performances of high bearing strength, high temperature resistance, deformability and strong binding powder of the cracked stratum, and can be applied to the leaking stoppage operation for the drilling engineering to solve the leakage problem at different degrees.