23results about How to "Improve microenvironment" patented technology

The invention relates to the technical field of medical biological materials, and discloses a mussel mucin-chondroitin sulfate composite hydrogel and a preparation method and application thereof, and the preparation method comprises the following steps: respectively preparing a mussel mucin aqueous solution and a chondroitin sulfate aqueous solution; the mass volume concentration of the mussel mucoprotein aqueous solution is 1%-10%, the mass volume concentration of the chondroitin sulfate aqueous solution is 1%-10%, the mass ratio of the mussel mucoprotein to the chondroitin sulfate is 3: 1-1: 3, the two solutions are mixed and stirred or oscillated under the conditions that the temperature is 4-37 DEG C and the pH value is 7.0-9.0, a cross-linking reaction is conducted, and hydrogel is formed; the cross-linking mode is physical cross-linking, chemical cross-linking or physical-chemical dual cross-linking; according to the invention, excellent tissue adhesion, injectability, self-healing property and biodegradability are realized, cell adhesion and proliferation can be effectively promoted, and the gel is suitable for various medical beauty scenes such as skin filling, wound repairing and anti-aging nursing.

This invention discloses a near-infrared light-exciteable composite nanosheet, its preparation method, and its applications, belonging to the field of biomedical technology. The method includes the following steps: mixing epigallocatechin gallate with a Ti3C2 nanosheet dispersion, ultrasonically reacting, adding silver salt, and continuing stirring in the dark; after the reaction is complete, washing and separating to obtain MXene-EGCG@Ag composite nanosheets. The composite nanosheets provided by this invention possess near-infrared light-exciteable properties and can be used to prepare medically acceptable dosage forms such as hydrogels for the treatment of periodontitis. The preparation method provided by this invention is simple, the raw materials are readily available, and it exhibits significant antibacterial and anti-inflammatory effects, enabling further widespread application.

The application discloses a tracheotomy fixing device and a control method thereof, and relates to the field of medical devices.The device comprises a fixing base assembly, an adjustable fixing belt system, an intelligent monitoring and adjusting module, a pressure sore prevention auxiliary structure and a wireless communication module.The fixing device can realize real-time acquisition of pressure data in the fixing area through a pressure sensor array, analysis and processing of the pressure data by an intelligent control unit, automatic adjustment of the tightness of the fixing belt by driving an electric adjusting actuator when an abnormal pressure trend is identified, and output of graded alarm information by an alarm unit, so that stable fixation of a tracheal cannula and safe management of pressure are realized.The fixing device can also improve the skin contact environment through a pressure reduction and air permeation structure, reduce the risk of pressure sores, support data interaction with a nursing terminal, and improve nursing efficiency.The application can realize a change from passive fixation to active safety management, and has good clinical application value.

This invention relates to a multifunctional bioactive dental bulk filling composite resin and its preparation method. The composite resin comprises an organic resin matrix and an inorganic filler; the organic resin matrix comprises polymerizable resin monomers and a photoinitiator system, the polymerizable resin monomers comprising dimethacrylate monomers and E-POSS; the inorganic filler comprises nMgO and sSiO2 with a silanized surface. The preparation method includes the following steps: preparing nMgO powder using a sol-gel method combined with a gradient calcination process; preparing submicron-sized sSiO2 using the Stöber method and subjecting it to surface silanization treatment to obtain silanized sSiO2; mixing the polymerizable resin monomers, E-POSS, and the photoinitiator system, stirring in the dark until a homogeneous resin matrix is ​​formed; adding the obtained nMgO and silanized sSiO2 to the resin matrix in a specific ratio and mixing and dispersing evenly to obtain an uncured paste-like composite resin.

The invention relates to a high-safety ring main unit, and relates to the technical field of electrical equipment, the high-safety ring main unit comprises a cabinet body, the cabinet body is provided with an overheat pressure relief device and a pressure balance device, and a driving component of the overheat pressure relief device is a driving element made of shape memory alloy to control a pull plate to slide to open a flashboard to release hot pressing in the cabinet body. A flexible diaphragm of the pressure balancing device is matched with the cabinet body and the thermal pressure relief device to form an airtight space, and the internal and external pressure difference of the box body is compensated through deformation after the overheating pressure relief device acts to relieve pressure. The ring main unit achieves the technical effects of effectively releasing the hot pressure in the cabinet body, compensating the pressure difference inside and outside the box body, improving the safety of the ring main unit and the like.

The application belongs to the technical field of biological detection, and particularly relates to an electrochemical nanosensor for detecting intracellular lactic acid in tumor cells and a preparation method and application thereof. A carbon fiber nanoelectrode (CFNE) with a tip diameter of about 150 nm is prepared by using a flame etching technique, and platinum nanoparticles (Pt NPs) are modified on the surface of the carbon fiber nanoelectrode to enhance the electrocatalytic activity of the electrode. Lactate dehydrogenase (LDH) is covalently cross-linked and fixed by using polyethyleneimine to construct an enzyme nanoelectrode (LDH / Pt / CFNE) for electrochemical detection of intracellular lactic acid in single cells. The sensing electrode has the characteristics of high sensitivity, good selectivity and excellent stability, realizes real-time and in-situ quantitative detection of intracellular lactic acid in single tumor cells, and is applied to tumor metabolism research, drug evaluation and mouse tumor model verification.

This invention discloses a traditional Chinese medicine composition for pulmonary nodules and its preparation method. The composition is prepared from the following components in parts by weight: 6-30 parts raw oyster shell, 3-15 parts Scrophularia ningpoensis, 3-15 parts Fritillaria thunbergii, 2-10 parts Uncaria rhynchophylla, 3-15 parts vinegar-processed turtle shell, 3-15 parts stir-fried Bombyx mori, 2-10 parts stir-fried mustard seed, 2-10 parts processed Pinellia ternata, 3-15 parts Codonopsis pilosula, 2-10 parts vinegar-processed Curcuma zedoaria, 3-15 parts Rhodiola rosea, 2-10 parts bee honeycomb, 6-30 parts lily bulb, 3-15 parts dried plum, 3-15 parts Ganoderma lucidum, 2-10 parts stir-fried bitter almond, 3-15 parts honey-processed mulberry bark, and 2-10 parts Scutellaria baicalensis. This invention has the functions of resolving phlegm and removing blood stasis, attacking toxins and dispersing nodules, invigorating qi and promoting qi circulation, and nourishing yin and moistening the lungs. It is used in medicines and health products for pulmonary nodules.

The application belongs to the technical field of biological nanomaterials, and particularly relates to a nano-enzyme material and a preparation method and application thereof. The application reacts dimethyl imidazole and metal salt in an aqueous solution to obtain a metal-dimethyl imidazole composite material solution, wherein the metal salt comprises copper salt and / or zinc salt; and reacts the metal-dimethyl imidazole composite material solution and tannic acid to obtain a nano-enzyme material. The nano-enzyme material provided by the application has excellent antioxidant enzyme-like catalytic activity and good biocompatibility, can effectively remove abnormally increased reactive oxygen species (ROS) in the process of myocardial infarction and myocardial ischemia-reperfusion injury, inhibit inflammatory response and myocardial cell apoptosis, improve the mitochondrial function state, thereby promoting the repair of damaged myocardial tissue and significantly improving the cardiac function, and provides a new technical solution for the treatment of myocardial infarction and related ischemic cardiovascular diseases.

The application discloses a whitening composition and a preparation method thereof. The whitening composition comprises undecylenoyl phenylalanine, Galium aparine extract, Terminalia arjuna bark extract, Ascophyllum nodosum extract and Dictyota fasciola extract. The whitening composition has excellent tyrosinase enzyme activity inhibiting effect, is mild and non-irritating, and has a good popularization and application prospect.

This invention discloses a near-infrared light-responsive thermo-electrically coupled titanium-based implant, its preparation method, and its application, belonging to the field of biomedical materials technology. The near-infrared light-responsive thermo-electrically coupled titanium-based implant provided by this invention comprises a porous titanium substrate and a composite hydrogel coating; the surface of the porous titanium substrate is sequentially disposed from the inside out with TiO2 / SrTiO3 heterojunctions, upconversion nanoparticles, and barium titanate nanoparticles; the upconversion nanoparticles are Yb. 3+ and Er 3+ Co-doped NaYF4 upconversion nanoparticles; a composite hydrogel coating is deposited on the surface of barium titanate nanoparticles, the composite hydrogel coating comprising MXene, pharmaceutically active ingredients, and a hydrogel carrier. This invention achieves synergistic coupling of photothermal and photoelectric-pyroelectric effects under near-infrared light irradiation by constructing a multi-layered synergistic structure on a porous titanium substrate, thereby synergistically realizing multiple functions such as promoting bone growth, antibacterial activity, and antitumor activity.

The present application relates to the technical field of traditional Chinese medicine extraction, and discloses a water chestnut peel extract and application thereof in preparation of a medicine for treating chloasma; during preparation of the extract, low-temperature extraction is carried out by using an acid-alcohol mixed solvent, and enrichment is carried out by using macroporous resin purification, so that the water chestnut peel extract with high purity of active ingredients and complete retention can be prepared, the utilization rate of active ingredients in the water chestnut peel is effectively improved, and resource waste is reduced. The water chestnut peel extract provided by the present application can effectively inhibit tyrosinase activity, and shows excellent treatment potential for chloasma, a pigment deposition disease, thereby providing a solution to the current situation that chloasma is difficult to treat.

The application discloses a composition for treating rhinitis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine formulae. The composition for treating rhinitis can effectively treat symptoms of nasal congestion and rhinorrhea, relieve nasal pain and dryness, stabilize the mood of a patient, and promote the exertion of drug efficacy. Meanwhile, the composition can eliminate inflammation, improve the microenvironment of a nasal cavity, promote metabolism waste to be discharged outside the body, improve the health and anti-allergy ability of the nasal cavity, and achieve the effect of treating both the symptoms and the root cause. The components are synergistically combined through fine proportioning and a specific decocting method, the effective components in the medicine are maximally reserved, the combination of the components is promoted, the prepared medicinal liquid is safe, has high safety, is suitable for a wide range of people, directly reaches the affected area, has smaller side effects on the body, can treat various types of rhinitis, is suitable for various treatment methods, and can break the curse that rhinitis cannot be radically treated.

The invention belongs to the technical field of traditional Chinese medicine nursing, and discloses a traditional Chinese medicine health-care comb and a preparation method thereof.The traditional Chinese medicine health-care comb is prepared through the steps that traditional Chinese medicine powder, nanmu sticky powder, a nanometer whisker reinforcing agent and composite antibacterial factors are subjected to dry mixing and then mixed with a traditional Chinese medicine extracting solution according to the mass ratio of 1: 1, and compression molding is conducted; the mass ratio of the traditional Chinese medicine powder to the nanmu sticky powder to the nano whisker reinforcing agent to the composite antibacterial factor is (65-70): (20-25): (5-8): (2-3); through a double-effect fusion mode of the medicine powder and the extracting solution, combination of physical massage and medicine effect permeation is achieved, compatibility of multiple medicinal materials is achieved, the traditional Chinese medicine theory and scalp care requirements are considered, and multiple health-care effects of nourishing blood and blacking hair, growing hair and preventing hair loss, promoting blood circulation to remove meridian obstruction and balancing the scalp environment are achieved; meanwhile, a nano whisker reinforcing agent and a composite antibacterial factor are also added, so that the problems that the traditional Chinese medicine health-care comb is easy to break and mildew and short in service life in life and use are solved.

The application relates to the technical field of magnesium alloys, and discloses a Mg-Zn-Ca-Sr medical magnesium alloy and a preparation method thereof, wherein the chemical composition of the alloy is as follows in percentage by mass: Zn 2.0%-6.0%, Ca 0.5%-2.0%, Sr 0.1%-1.0%, inevitable impurity elements less than or equal to 0.2%, and the balance of Mg. The magnesium alloy has good mechanical properties, a degradation rate and biological activity, and provides a solution to the clinical problems such as non-degradability, non-matching elastic modulus and lack of biological activity of traditional medical metals.

The invention discloses a preparation process of a controlled-release fertilizer taking steel slag as a base material, which comprises the following steps: grinding and screening the steel slag to obtain 40-400-mesh steel slag powder; dissolving half of the solid nutrient in water to obtain a nutrient solution, adding the steel slag powder and the bio-based auxiliary material, fully mixing and adsorbing, and drying to obtain a nutrient-loaded substrate material; continuously mixing the residual solid nutrients with the nutrient-loaded substrate material, adding the coating material A as a binder, carrying out blending granulation in a granulator, and drying to obtain an inner core; adding the inner core into a coating machine, adding a coating material B for coating, and drying to obtain the slow / controlled-release fertilizer. According to the invention, the steel slag powder and the bio-based auxiliary material are used as carriers, heavy metal pollutants are stabilized while the soil agglomeration structure is improved through double mechanisms of physical adsorption and chemical immobilization, and the effects of slow / controlled-release fertilizer and soil improvement are realized.

This invention belongs to the field of genetic engineering technology, specifically relating to a modular tandem repeat recombinant type III collagen with high platelet adhesion and its applications. The amino acid sequence of the recombinant type III collagen includes repeating units, with ≥3 repeating units; functional modules are inserted within each repeating unit. This invention integrates multiple discrete platelet-binding sites in type III collagen, designs a tandem repeat structure of different modular sequences (≥3 repeating units), optimizes spatial synergy, optimizes the gene sequence using codon bias, efficiently expresses the gene through a Pichia pastoris expression system, and obtains a high-purity product after purification. The recombinant type III collagen prepared by this invention exhibits good biocompatibility and can significantly promote erythrocyte and platelet adhesion; it can be widely used in wound repair, hemostatic materials, and tissue engineering.

This invention discloses a method for the coordinated removal of products from near-atomic-scale electrochemical machining, along with its system apparatus and applications. The core of this method lies in the synergistic use of chemical complexation, pulsed electric field modulation, and interfacial electrostatic repulsion to proactively address the problem of product blockage within near-atomic-scale machining channels. Specifically, by adding a strong complexing agent to the electrolyte, the metal ions generated during machining are converted in situ into soluble complexed anions. A composite waveform, including an anodic pulse during machining, a zero-potential intermittent period during diffusion, and a reverse cathode pulse during impurity removal, provides dual impurity removal momentum through diffusion and electromigration. Simultaneously, the inner wall of the ion channel protein is negatively modified to reduce product transport resistance and adsorption through electrostatic repulsion. The synergistic effect of these three mechanisms enables effective and continuous product management without compromising machining locality. Correspondingly, this invention also provides a dedicated machining system for implementing this method and its application in the machining of easily passivated metal materials.

This application provides a hydrogel for diabetic foot wound dressing and its application. The hydrogel comprises: a hydrogel carrier for loading a traditional Chinese medicine extract; and the traditional Chinese medicine extract loaded on the hydrogel carrier. The traditional Chinese medicine extract is obtained by oil extraction and wall material embedding of a traditional Chinese medicine composition. The wall material is selected from one or more of β-cyclodextrin, hydroxypropyl-β-cyclodextrin, chitosan-modified β-cyclodextrin, and chitosan-phenylboronic acid-modified β-cyclodextrin. This application obtains the traditional Chinese medicine extract by embedding the oil extract of the traditional Chinese medicine composition raw material into the wall material, and loads the traditional Chinese medicine extract onto the hydrogel carrier to obtain a hydrogel for diabetic foot wound dressing. This hydrogel can provide a favorable microenvironment for wound healing, and in conjunction with the effective components in the traditional Chinese medicine extract, can effectively inhibit inflammation and promote wound healing.

This invention relates to a three-dimensional porous bioactive scaffold, a vascularized bone organoid, its preparation method, and its applications, belonging to the field of tissue engineering technology. The bioactive scaffold includes a scaffold body, a Piezo1 channel agonist loaded on the scaffold body, and an Nrf2 agonist and / or Nrf2 expression vector loaded on the scaffold body; the scaffold body is a 3D-printed PMBG / β-TCP composite porous scaffold. The vascularized bone organoid uses the three-dimensional porous bioactive scaffold as a supporting framework and also includes cellular components, including co-cultured bone marrow mesenchymal stem cells and endothelial cells. Compared with existing technologies, this invention successfully constructs a novel vascularized bone organoid capable of targeting the Piezo1-Nrf2 signaling axis and possessing anti-endothelial aging and mechanical enhancement functions.

The invention belongs to the technical field of cosmetics, and particularly relates to a cyclic peptide with functions of promoting collagen synthesis, hair follicle activation and scalp aging resistance and application of the cyclic peptide in cosmetics. According to the invention, a novel cyclic peptide capable of regulating and controlling hair follicle activation and scalp anti-aging related signal channels is found through peptide library screening, and a structurally-similar peptide of the cyclic peptide is synthesized, and the structure of the cyclic peptide is shown as a formula (I) or (II). The cyclic peptide can effectively up-regulate the expression of hair follicle activation marker genes, promote the proliferation of hair follicle dermal papilla cells and enhance the antioxidant capacity, and can also promote the synthesis of collagen, so that the cyclic peptide can be used for preparing cosmetic compositions for preventing and treating alopecia, promoting hair growth and resisting scalp aging. (I) (II)

The invention relates to the technical field of biomedical materials, discloses a preparation method of a bone repair mineralized biological membrane capable of inducing gene expression and a product, and aims at solving the problems that an existing bone repair material HAP crystal is difficult to regulate and control, the mechanical activity and the biological activity are not matched, bone induction is weak, the process is complex and the like. The preparation method comprises the following steps: S1, preparing a decellularized small intestinal submucosa (SIS) membrane and sterilizing; s2, constructing a pDA-PAM (at) SIS composite membrane; s3, inducing directional growth of HAP through ion permeation biomimetic mineralization; and S4, cleaning and drying to obtain the HAP / SIS collagen mineralized biological membrane. The product contains an SIS collagen matrix and low-crystallinity nano HAP (the width is 4-20nm, the length is 31-105nm, and the product is oriented along a c axis), the tensile strength is greater than or equal to 13MPa, the elastic modulus is greater than or equal to 75MPa, the specific surface area is greater than or equal to 60m < 2 > / g, and osteogenic genes such as ALP, Runx2 and the like can be up-regulated by more than or equal to 2 times. The method is mild in process, easy to operate, good in biocompatibility, high in bone conduction and inductivity, suitable for large-scale production and capable of meeting the clinical bone defect repair requirement.

The invention relates to the technical field of compound fertilizers, and provides a high-temperature-resistant bacteria-containing compound fertilizer and a preparation method thereof.The preparation method comprises the following steps that nanoscale freeze-dried bacterial powder is prepared from bacillus, bacillus stearothermophilus and rhodopseudomonas palustris; mixing the nano TiO2 modified SiO2 composite aerogel, diatomite, the modified charcoal, sepiolite and pullulan to prepare a microbial inoculum protection composite carrier; and mixing the freeze-dried bacterial powder with a carrier, and drying to obtain the micron-sized capsule bacterial agent. Uniformly mixing a reinforcing agent, a plasticizer and a stabilizer to prepare a performance regulator; the preparation method comprises the following steps: melting choline chloride-containing urea and monoammonium phosphate to prepare molten slurry; mixing the molten slurry with a compound fertilizer to form uniform slurry; and mixing the slurry with a micron-sized capsule microbial inoculum and a performance regulator, and granulating to obtain the high-temperature-resistant bacterium-containing compound fertilizer. By optimizing the adaptability of a microbial agent embedding carrier and a melting system, the technical bottleneck of conflict between high-temperature inactivation of the microbial agent and physical properties of a product is solved.

This invention belongs to the field of daily chemical products technology, specifically relating to a pure herbal hair growth and anti-hair loss shampoo based on multi-pathway synergistic effects and its preparation method. The herbal hair growth and anti-hair loss shampoo comprises: hair follicle regulating ingredients, blood circulation promoting ingredients, antibacterial and antipruritic ingredients, and natural surfactant ingredients. This invention scientifically proportions the above ingredients. The extract obtained from the hair follicle regulating ingredients regulates sebum secretion in hair follicles; the extract obtained from the blood circulation promoting ingredients promotes blood circulation in scalp capillaries; the extract obtained from the antibacterial and antipruritic ingredients inhibits scalp infections and hair follicle inflammation; and the surfactants give the shampoo good stability. This invention, through the multi-pathway synergistic effects of the above components, solves the shortcomings of existing herbal shampoo products, such as simple formulas, insufficient extraction of effective ingredients, reliance on chemical surfactants, and limited efficacy. It has the advantages of being natural, gentle, non-irritating, and having a high utilization rate of effective ingredients.