The invention discloses a pharmaceutical combination for treating children enteritis and a preparing method thereof. The pharmaceutical combination is composed of main materials and auxiliary materials, wherein the main materials include saruma henryi, artemisia apiacea, coptis chinensis, humifuse euphorbia herb, radix sophorae flavescentis, eucalyptus leaves, radices sileris, bighead atractylodes rhizome, pericarpium papaveris, agastache rugosus, poria cocos, pericarpium arecae, folia perillae acutae, radix angelicae, orange peel, mangnolia officinalis, liquorice, cassia twig, round cardamom fruit, hedyotis chrysotricha, the root of Chinese pulsatilla and caulis lonicerae, and the auxiliary materials include pearl powder, pectin powder, tannalbin, pepsin, polyzyme tablets, lactasin, yeast tablets, calcium lactate powder and multivitamins. The medicine is made from materials with mild properties, is capable of protecting gastrointestinal mucous membranesm, stopping diarrhea, aiding digestion, stopping vomiting, supplementing essential nutrients and clearing heat and promoting diuresis, has a definite curative effective for children enteritis, and is convenient to take, safe, free of toxic and side effect, and suitable for bulk production.