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52 results about "Gastric pepsin" patented technology

Pepsin, the powerful enzyme in gastric juice that digests proteins such as those in meat, eggs, seeds, or dairy products.

Bi-crosslinking acellular matrix hydrogel as well as preparation method and application thereof

The invention provides double-crosslinking acellular matrix hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogel. The preparation method comprises the following steps: (1) carrying out decellularization treatment on a porcine dermal layer to obtain a decellularized porcine dermal matrix, (2) putting freeze-dried powder of the decellularized porcine dermal matrix into an acidic pepsin solution, stirring and digesting, adjusting the concentration, adding 10xPBS, adjusting the pH value to obtain a pregel solution, and carrying out freeze-drying on the pregel solution to obtain the porcine dermal matrix freeze-dried powder. (3) putting gel formed by the pre-gel solution into a tannic acid solution for cross-linking to obtain mono-cross-linked acellular matrix hydrogel; (4) smashing the mono-cross-linked acellular matrix hydrogel, and mixing the smashed mono-cross-linked acellular matrix hydrogel with a glucose oxidase solution and a ferrous ion solution with the concentration of 0.1-10mg / ml to obtain a bi-cross-linked acellular matrix hydrogel precursor; 5, the double-crosslinking acellular matrix hydrogel precursor is placed under the condition of glucose with the concentration being 10-200 mg / dl to form the double-crosslinking acellular matrix hydrogel. The hydrogel prepared through the method can achieve the balance of safety, supporting performance and degradability, and is wide in application range.
Owner:SICHUAN UNIV

Method for extracting micro-plastics in soil of refuse landfill

The invention discloses a method for extracting micro-plastics in soil of a refuse landfill. The method comprises the following steps: pretreating a refuse landfill soil sample to obtain sample soil; the sample soil and an extracting agent are fully mixed and oscillated and then stand for layering, first supernate is obtained, the extracting agent is added at least twice, the types of the extracting agent added each time are different, and the extracting agent added each time is one of saturated sodium chloride, saturated sodium bromide and saturated sodium iodide; the first supernate is extracted and fully mixed with a digesting agent, the mixture is shaken and then stands for layering again, second supernate is obtained, and the digesting agent is at least one of 30% hydrogen peroxide, a Fenton reagent, pepsin and trypsin; and filtering the second supernatant to obtain the micro-plastic. Therefore, the extraction method provided by the embodiment of the invention has multiple technical effects of high efficiency, deep digestion, accurate filtration, wide applicability, environmental friendliness and the like.
Owner:NORTHWEST A & F UNIV +2

Highland barley fried malt polysaccharide capable of promoting digestion as well as preparation method and application of highland barley fried malt polysaccharide

The invention discloses a digestion-aiding highland barley fried malt polysaccharide as well as a preparation method and application thereof. The polysaccharide is extracted from highland barley through hot water extraction, ethanol precipitation, deproteinization, ion exchange column chromatography, gel column chromatography and dialysis processes. Animal experiments show that the polysaccharide can significantly improve the small intestine propulsion rate of mice and increase the weight increment, gastric juice amount, pepsin activity and pepsin discharge of rats, and the effect of the polysaccharide is superior to that of traditional roasted barley malt polysaccharide; the highland barley polysaccharide is superior to highland barley crude polysaccharide, highland barley polyphenol, highland barley lipid, highland barley protein and the like. The invention has the advantages of easily available raw materials and green process, is suitable for developing side-effect-free digestion-aiding functional foods such as tea bags, milk tea, yoghurt and biscuits, and has important market value.
Owner:SHANGHAI JIAOTONG UNIV +1

Lamb stomach extract vitamin b12 preparation composition and the use in the treatment of gastric disease thereof

PendingUS20250195583A1Organic active ingredientsDigestive systemSTOMACH EXTRACTMetaplasia
A lamb stomach extract Vitamin B12 preparation composition composed of lamb stomach extract and Vitamin B12 is provided. The lamb stomach extract has a chymosin activity of >40 U / g and a pepsin activity of >15 U / g, and the weight ratio of the lamb stomach extract and Vitamin B12 is 100000:0.5-5, which is useful in the treatment of moderate-to-severe chronic atrophic gastritis, intestinal metaplasia reversal, and gastric cancer prevention. Lamb stomach extract and Vitamin B12 produced synergistic or synergistic effects in specific ratios.
Owner:ZHAO XINMIN

Preparation method and device of SOD resistant to pepsin degradation

The application belongs to the field of SOD preparation, and discloses a preparation method and device of SOD resistant to pepsin degradation, which comprises the following steps: S1 powder preparation: dissolving SOD fermentation pure liquid in a buffer solution with pH of 5.2-7.8, adding protective agent and tea yellow in sequence, stirring, filtering, and placing in a freeze dryer to prepare freeze-dried powder; S2 drying; S3 tabletting; S4, coating liquid preparation: dissolving wheat gliadin and soybean protein in a mixed solution prepared from water and ethanol with a volume ratio of 1:1, wherein the mass ratio of the wheat gliadin and the soybean protein is 0.5-1:1, adding glycerol, stirring for 20 min by using a magnetic stirrer, and ultrasonicating for 40 s; S5, coating: placing the tablets in a coating machine, setting air inlet volume, air inlet temperature, pan rotating speed, atomization rate, fan face pressure, and mortar flow, until the coating weight increases to 3%-10% in mass fraction and the coating thickness is 20-50 μm, and then drying and cooling. The prepared SOD is not easy to be photolyzed and can resist gastric acid degradation to ensure the complete activity of the SOD.
Owner:HUBEI PRETIN BIOTECHNOLOGY CO LTD

Preparation for promoting gastrointestinal digestion and preparation method and application thereof

The invention discloses a preparation for promoting gastrointestinal tract digestion and a preparation method and application thereof. The preparation comprises the following components in parts by weight: 20-40 parts of hawthorn, 30-50 parts of fried malt, 60-80 parts of Chinese yam, 3-18 parts of pericarpium citri reticulatae, 10-30 parts of radix fici simplicissimae, 10-30 parts of hericium erinaceus, 3-18 parts of liquorice, 20-40 parts of bifidobacterium animalis subsp. Lactis, 20-40 parts of casei casei, 20-40 parts of plant lactobacillus and 3-18 parts of lactobacillus acidophilus. In the preparation, the traditional Chinese medicine formula has the effects of strengthening the spleen and stomach, promoting digestion and relieving stagnation, the probiotics regulate intestinal flora balance and promote digestion and absorption of the body, the traditional Chinese medicine formula and the probiotics synergistically play a role in promoting digestion, improving gastrointestinal motility and promoting secretion of gastric juice and pepsase, and the preparation has a positive effect on maintaining gastrointestinal health.
Owner:ZHONGSHAN ZHONGZHI PHARMA GRP

A method for preparing a gastric transit-stable enzyme preparation

The application belongs to the technical field of enzyme preparation processing, and specifically provides a preparation method of a gastric-stable enzyme preparation, which comprises the following steps: (1) placing enzyme liquid in a stirrer, adding stabilizers and carriers into the enzyme liquid, uniformly stirring, then adding emulsifiers and emulsion stabilizers, uniformly stirring again, obtaining enzyme mixture, and heating and keeping warm; (2) heating hot-melt type packaging materials to completely melt into liquid state, and keeping the packaging materials in liquid state; (3) starting the stirrer, slowly pouring the liquid hot-melt type packaging materials into the stirrer while stirring, and obtaining a material liquid; (4) spray drying the material liquid, and obtaining the gastric-stable enzyme preparation. The preparation method provided by the application effectively avoids the destruction of the prepared enzyme preparation by pepsin after the enzyme preparation enters the stomach of an animal, improves the enzyme activity retention rate of the enzyme preparation product after passing through the stomach, and further improves the stability of the enzyme preparation in the storage process, especially the storage stability in a humid environment.
Owner:WUHAN SUNHY BIOLOGICAL

A pharmaceutical composition for treating peptic gastric ulcer and its preparation method

The present invention relates to a pharmaceutical composition for treating peptic gastric ulcer and a preparation method thereof, belonging to the field of biotechnology. The pharmaceutical composition contains chicken gizzard-membrane peptide, pumpkin seed extract, complex bacteria, white hyacinth bean flower extract and bletilla striata extract; the chicken gizzard-membrane peptide contains the products obtained by successively subjecting chicken gizzard-membrane to fractional enzymolysis with pepsin, chymotrypsin and keratinase; the pumpkin seed extract contains the products obtained by subjecting pumpkin seeds to co-enzymolysis with cellulase and pectinase and then successively to fractional enzymolysis with pepsin, nattokinase and aminopeptidase; the complex bacteria contain the co-fermentation bacteria of Lactobacillus acidophilus, Bifidobacterium and Lactobacillus casei; the white hyacinth bean flower extract is an ethanol percolation extract; the bletilla striata extract contains the products obtained by subjecting bletilla striata tubers to co-enzymolysis with cellulase and pectinase and then successively to fractional enzymolysis with pepsin, bromelain and serrapeptase. The various components are used in combination, having a good therapeutic effect on gastric ulcer, quickly and efficiently repairing gastric mucosa, and being safe and free of side effects.
Owner:GENERAL HOSPITAL OF SOUTHERN THEATRE COMMAND OF PLA

Packaging box (compound pepsin granules)

ActiveCN309898214SEngineeringBiochemistry
1. Name of the designed product: packaging box (compound pepsin granules). 2. Use of the designed product: for product packaging. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: front view.
Owner:HUNAN ZHUANGYUAN PHARM CO LTD

Multi-step enzymolysis desensitization process for preparing hypoallergenic beta-lactoglobulin peptide and application of multi-step enzymolysis desensitization process

The invention discloses a multi-step enzymolysis desensitization process for preparing low-sensitization beta-lactoglobulin peptide and application, and belongs to the technical field of food safety detection. According to the method disclosed by the invention, the anaphylaxis of the beta-lactoglobulin can be obviously reduced, and the antigen reduction rates are 62.46% (the combination of pepsin and papain) and 71.81% (the combination of bromelain and pepsin) respectively. The low-anaphylaxis beta-lactoglobulin peptide can effectively maintain the spleen index and the body temperature of an allergic model mouse at the physiological level, reduce the level of IgE (Immunoglobulin E) and improve the protective barrier of intestinal tracts. On the basis, the method can be effectively applied to development of food industry and functional food, meanwhile, technical support is provided for development of dairy product raw materials and products with higher safety, and wide industrial application prospects are shown.
Owner:DALIAN POLYTECHNIC UNIVERSITY +1

Depression relieving and liver soothing pill and preparation method thereof

The invention discloses a depression-relieving and liver-soothing pill and a preparation method thereof, and belongs to the technical field of Chinese patent medicines. The depression-relieving and liver-soothing pill comprises the following active ingredients: vinegar-processed rhizoma cyperi, grape seeds, bran-fried rhizoma atractylodis macrocephalae, poria cocos, hawthorn, pericarpium citri reticulatae, ginger-fried fructus gardeniae, vinegar-processed rhizoma corydalis, fructus aurantii, betel nuts, liquorice, medicated leaven, pericarpium citri reticulatae viride, radix aucklandiae, fructus amomi and radix linderae. According to the invention, the alcohol extract of the grape seeds is added into the traditional depression-relieving and liver-soothing pill, so that the depression-relieving and liver-soothing pill is obviously improved in the effect of enhancing the activity of pepsin and pancreatin, and a better instant curative effect can be obtained when the depression-relieving and liver-soothing pill is used for treating chest and hypochondrium fullness, inappetence and other symptoms.
Owner:CIXI MATERNAL & CHILD HEALTH HOSPITAL

A highly acid-tolerant bacillus velezensis strain lybv022-ac R and its progressive acid stress domestication screening method and application

This invention discloses a highly acid-resistant Bacillus belye strain LYBV022-Ac R This invention relates to a method for screening and acclimating bacteria under progressive acid stress, and its application, belonging to the technical field of industrial microbial breeding and probiotic application. The disclosed high-acid-resistant Bacillus belyeis LYBV022-Ac... R By designing a pH gradient decreasing (6.5→3.0) acclimatization strategy and combining it with microplate rapid screening technology, a breakthrough improvement in acid resistance was achieved. After exposure to a simulated gastric acid environment (pH 3.0, containing pepsin) for 4 hours, the survival rate reached 48.52%, a 970-fold increase compared to the original strain (0.05%), while maintaining excellent growth performance and genetic stability. This invention also provides the application of this strain in the preparation of oral probiotic preparations for livestock and poultry, solving the common technical problem of insufficient potency in oral Bacillus preparations due to gastric acid damage.
Owner:LONGYAN UNIV

Preparation method and application of artemisia rupestris n-butyl alcohol effective part extract

PendingCN119074790Aincrease secretionHigh emptying rateDigestive systemPlant ingredientsArginineGastric pepsin
The invention relates to a preparation method and application of an artemisia rupestris n-butyl alcohol effective part extract. The method comprises the following steps: crushing the whole herb of artemisia rupestris, adding water, uniformly mixing, carrying out reflux extraction, combining, filtering, carrying out reduced-pressure recovery and concentration to obtain an artemisia rupestris water extract, extracting with n-butyl alcohol, combining extract liquor, carrying out reduced-pressure concentration, and carrying out vacuum drying to obtain the effective part extract of the artemisia rupestris n-butyl alcohol. The extract obtained by the method provided by the invention has three experiments of influence on gastric acid, gastric secretion volume and pepsin activity of a rat with functional dyspepsia caused by a composite molding method, influence on gastrointestinal function of a mouse with functional dyspepsia caused by L-arginine, influence on gastrointestinal motility of a normal mouse and the like; it is proved that the artemisia rupestris n-butyl alcohol effective part extract has activity in the aspect of effectively relieving functional dyspepsia and gastrointestinal motility disorder, and a new way is further provided for the aspect of functional dyspepsia treating medicine through the extract.
Owner:斯拉甫·艾白

Packaging box (compound pepsin)

ActiveCN309620414SEngineeringBiochemistry
1. Name of the designed product: packing box (compound pepsin). 2. Use of the designed product: for product packing. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: front view.
Owner:HUNAN ZHUANGYUAN PHARM CO LTD

Tea rice soup capable of nourishing stomach and enhancing immunity and preparation method of tea rice soup

The invention belongs to the technical field of food processing, and particularly relates to tea rice soup capable of nourishing the stomach and enhancing immunity and a preparation method of the tea rice soup. Comprising the following raw materials in parts by mass: 100-150 parts of glutinous rice, 5-10 parts of red dates, 3-5 parts of honey, 6-10 parts of red beans, 4-5 parts of beef powder, 2.5-3 parts of peanut kernels, 6-10 parts of fruit and vegetable juice, 3-5 parts of a traditional Chinese medicine extract, 4 parts of peach gum, 0.5 part of tea powder, 0.8-1.2 parts of hericium erinaceus powder, 1 part of sea buckthorn fruit powder and 0.5-1 part of wheat oligopeptide. According to the tea-rice soup capable of nourishing the stomach and enhancing the immunity, the basic raw materials form a protective film, repair is enhanced, nutrient absorption is assisted, and the immune raw materials are stable; the fruit and vegetable juice generates substances easy to absorb energy, mucous membrane repair is promoted, and immunostimulation is enhanced; the traditional Chinese medicine extract inhibits pepsin, promotes mucous membrane synthesis, activates immune cells and reduces inflammatory factors.
Owner:ZHEJIANG ANJI MINGYUN CATERING CULTURE MANAGEMENT CO LTD

Aerosolized formulations of HIV protease inhibitors for the treatment of airway reflux

ActiveUS12678453B2AerosolizeHIV Protease Inhibitor
The present invention provides methods of treating airway reflux using an HIV protease inhibitor that is capable of binding to and inhibiting the enzymatic activity of pepsin. Compositions comprising aerosolized formulations of HIV protease inhibitors are also provided.
Owner:MEDICAL COLLEGE OF WISCONSIN INC

Preparation method of lactic acid bacteria fermentation extract dairy product

PendingCN122004296AAchieve targeted enrichmentGuaranteed stabilityMilk preparationBiotechnologyInflammatory factors
The invention discloses a preparation method of a lactic acid bacteria fermentation extract dairy product, and belongs to the technical field of dairy product processing. The method comprises the following steps: (1) mixing eclipta and glossy privet fruit according to a weight ratio of 1: (0.5-2), adding water, extracting, and concentrating to obtain an eclipta-glossy privet fruit extract; (2) mixing the skimmed milk with the herba ecliptae-glossy privet fruit extract, sterilizing, inoculating lactic acid bacteria, and fermenting until the pH value is 4.2-4.8 to obtain fermentation liquor; (3) sequentially carrying out two-step enzymolysis on the fermentation liquor through pepsin and trypsin to obtain enzymatic hydrolysate; (4) centrifuging the enzymatic hydrolysate, taking supernatant, enabling the supernatant to sequentially pass through ultrafiltration membranes with the molecular weight cut-off of 8kDa and 5kDa, and collecting components with the molecular weight of 5-8kDa; and (5) mixing the obtained components with the dairy product base material and the sweetening agent, homogenizing, and sterilizing to obtain the product. Through combination of fermentation, enzymolysis and ultrafiltration separation, active components in a specific molecular weight interval are enriched, and the prepared dairy product has the effects of inhibiting periodontal pathogenic bacteria and regulating inflammatory factors and can be used for daily prevention and adjuvant therapy of periodontitis.
Owner:ZUNYI MEDICAL UNIVERSITY

Preparation method and device of SOD (superoxide dismutase) capable of resisting pepsin degradation

The invention belongs to the field of SOD preparation, and discloses a pepsin degradation resistant SOD preparation method and device, the method comprises the following steps: S1, powder preparation: dissolving SOD fermentation pure liquid in a buffer solution with the pH value of 5.2-7.8, sequentially adding a protective agent and theaflavin, stirring, filtering, and putting into a freeze dryer to prepare freeze-dried powder; s2, drying; s3, tabletting; s4, preparing a coating solution, namely dissolving wheat gliadin and soybean protein in a mixed solution prepared from water and ethanol in a volume ratio of 1: 1, adding a plasticizer, stirring for 20 minutes by using a magnetic stirrer, and performing ultrasonic treatment for 40 seconds, wherein the mass ratio of the wheat gliadin to the soybean protein is (0.5-1): 1; and S5, coating: placing the tablets in a coating machine, setting the air inlet rate, the air inlet temperature, the pot rotating speed, the atomization rate, the sector pressure and the guniting flow until the weight of the coating is increased to 3-10% by mass and the thickness of the coating is 20-50 microns, and drying and cooling. The method has the beneficial effects that the prepared SOD is not easy to be photolyzed, and can resist gastric acid degradation, so that the complete activity of the SOD is ensured.
Owner:HUBEI PRETIN BIOTECHNOLOGY CO LTD

Bone gelatin process

A process for the production of bone gelatin includes demineralization of bone using a demineralization solution of acid, wherein the bone is washed for a demineralized time in the demineralization solution to remove soft tissue. The demineralized bone is then pulverized to produce particles of the demineralized bone in a homogenized bone tissue. Lipids are then removed from the homogenized bone tissue using a lipid removal series of washing steps which may include washing the homogenized bone tissue in a series of solutions, including a lipid removal solution and an ethanol solution. Gelatin is then removed from the lipid removed bone tissue in a gelatin extraction process, wherein lipid removed bone tissue is placed in a pepsin solution followed by an extraction solution. The gelatin from the gelatin extracted bone tissue may then be separated and the bone gelatin may then be lyophilized.
Owner:HUMABIOLOGICS INC

Pharmaceutical composition for reducing blood fat and blood pressure and preparation method thereof

The invention provides a pharmaceutical composition for reducing blood fat and blood pressure and a preparation method thereof, and belongs to the technical field of biological pharmacy, the pharmaceutical composition comprises durian honey seed extract, brassica campestris root-allium wilt composite extract, gastrodin, rhynchophylline, eucommia ulmoides glycoside and puerarin. The durian honey seed extract is prepared by performing enzymolysis on durian honey seeds through cellulase and pectinase, performing enzymolysis step by step through pepsin and ginger protease, adding a DES cosolvent, performing ultrasonic extraction, and performing MCI GEL CHP20P column purification. The red brassica campestris root-allium cervi composite extract is prepared by fermenting red brassica campestris roots and allium cervi herbs through lactobacillus rhamnosus and purifying fermentation liquor through a macroporous adsorption resin HP2MG column. All the components are matched for use, triple optimization of safety-drug effect-mechanism cooperation is achieved, the problems that western medicine is single in target spot and remarkable in side effect after being used for a long time are avoided, and the defects that traditional Chinese medicine is extensive in preparation and unstable in curative effect are overcome.
Owner:GUANGDONG ZONOPO INTELLIGENT TECH

Bone gelatin process

A process for the production of bone gelatin includes demineralization of bone using a demineralization solution of acid, wherein the bone is washed for a demineralized time in the demineralization solution to remove soft tissue. The demineralized bone is then pulverized to produce particles of the demineralized bone in a homogenized bone tissue. Lipids are then removed from the homogenized bone tissue using a lipid removal series of washing steps which may include washing the homogenized bone tissue in a series of solutions, including a lipid removal solution and an ethanol solution. Gelatin is then removed from the lipid removed bone tissue in a gelatin extraction process, wherein lipid removed bone tissue is placed in a pepsin solution followed by an extraction solution. The gelatin from the gelatin extracted bone tissue may then be separated and the bone gelatin may then be lyophilized.
Owner:HUMABIOLOGICS INC

Fried cheese formula and preparation method thereof

The invention relates to the technical field of dairy product processing, in particular to a fried cheese formula and a preparation method thereof, and the fried cheese formula comprises the following components by mass: raw milk subjected to standardization treatment, animal type chymosin, a leavening agent, calcium chloride and edible salt; the animal type chymosin is a mixture of rennase and bovine pepsase according to a mass ratio of 70: 30, the activity of the chymosin is greater than or equal to 890 IMCU / g, the addition amount of the chymosin is 43 g / t, and the chymosin is used for improving the curding efficiency and the structural stability; the leavening agent is lactococcus lactis subsp.cremoris and lactococcus cremoris, the addition amount of the leavening agent is 4D / t, and the leavening agent is used for increasing the flavor and fragrance of the product; the addition amount of the calcium chloride is 70g / t, and the calcium chloride is used for strengthening protein network crosslinking. According to the invention, the raw milk is standardized, so that the quality stability of the product is obviously improved; the thermal stability is optimized, and the eating scene is expanded; and strains capable of generating flavor substances are added, so that flavor levels are rich, the mouth feel is fine and elastic, and the eating experience is upgraded.
Owner:XINJIANG SHIHEZI HUAYUAN DAIRY IND CO LTD

Preparation method of mixed berry yoghourt

The invention discloses a preparation method of mixed berry yoghurt, which comprises the following steps: (1) preparing soy isolate protein powder enzymatic hydrolysate, and dividing the enzymatic hydrolysate into two parts, namely enzymatic hydrolysate I and enzymatic hydrolysate II; (2) preparing a mushroom extracting solution; adding the enzymatic hydrolysate I to obtain a composite liquid I; (3) adding pepsin into the enzymatic hydrolysate II, and adding threonine and L-lysine to obtain a compound liquid II; (4) mixing the strawberry particles, the blueberry particles and the raspberry particles to obtain mixed particles, and crushing and stirring the mixed particles to obtain mixed raspberry pulp; and mixing raw milk, white granulated sugar, the compound liquid I, the compound liquid II and the mixed berry pulp, performing homogenization treatment, performing pasteurization, inoculating a fermentation strain, performing fermentation, and performing cold storage so as to obtain the mixed berry yoghourt. The yoghurt prepared by the method disclosed by the invention has relatively high water holding capacity, good tissue form and fine and uniform texture; the fruit fragrance is strong, and the taste is very good.
Owner:JIANGXI SUNSHINE DAIRY CO LTD

Packaging box (pepsin tablets)

ActiveCN309824397S8EngineeringBiochemistry
1. Name of the product in this design: Packaging box (pepsin tablets). 2. Purpose of this design: This product is used for packaging pharmaceuticals. 3. The key design features of this product are its pattern and the combination of pattern and shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.
Owner:HENAN SHUANGHUI INVESTMENT DEV CO LTD

Aerosolized formulations of HIV protease inhibitors for the treatment of airway reflux

PendingAU2021257341B2AerosolizeHIV Protease Inhibitor
The present invention provides methods of treating airway reflux using an HIV protease inhibitor that is capable of binding to and inhibiting the enzymatic activity of pepsin. Compositions comprising aerosolized formulations of HIV protease inhibitors are also provided.
Owner:MEDICAL COLLEGE OF WISCONSIN INC

Magnetic microsphere as well as preparation method and application thereof

The invention relates to the field of biomedical engineering and drug delivery, in particular to a magnetic microsphere and a preparation method and application thereof. The preparation method of the magnetic microspheres comprises the following steps: dissolving curcumin in absolute ethyl alcohol to obtain a uniform solution; and injecting the uniform solution into water for self-assembly, and then freeze-drying to obtain the curcumin nanoparticles, the preparation method comprises the following steps: dissolving methacrylated gelatin, Fe3O4 coated SiO2 magnetic nanoparticles, curcumin nanoparticles and a photoinitiator in water to obtain an injection phase solution; forming uniform liquid drops from the injection phase solution through a micro-fluidic device, and then carrying out photocuring crosslinking to obtain the magnetic microspheres. The magnetic microspheres can be adsorbed to the esophagus in a targeted manner under the action of an external magnetic field, and curcumin is triggered by reflux gastric juice (gastric acid, pepsin and bile salt) to be released, so that the gastroesophageal reflux disease is treated.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV

Serum detection equipment for early screening of gastric cancer

The utility model belongs to the technical field of serum detection equipment, and particularly relates to serum detection equipment for gastric cancer early screening, which comprises a detection box, a treatment groove and a detection groove are formed in the detection box, a treatment mechanism comprises a treatment box and a pick-and-place assembly, and an extractor and a dilution tube are fixed at the output end of the pick-and-place assembly; the detection mechanism comprises a driving motor, a driving screw rod and a lifting plate, a plurality of placement grooves are formed in the top of the lifting plate, and detection plates are detachably connected into the placement grooves; serum is placed in the treatment box and diluted through the dilution pipe, then the taking and placing assembly drives the suction device to extract a sample, the serum is dropped into the detection hole in the detection plate, the lifting plate and the detection plate are driven by the driving motor to move to a detection area, and the detection area is detected. The detection box is used for detecting pepsinogen I (PGI), pepsinogen II (PGII) and the ratio of PGI to PGII in serum through a chemiluminescence method.
Owner:NANJING JINYU MEDICAL TESTING CENT CO LTD

Andrias davidianus skin non-denatured collagen hydrogel dressing and preparation method thereof

PendingCN122624723ASkin repairGiant salamander
The application provides a giant salamander skin non-denatured collagen hydrogel dressing and a preparation method thereof. The giant salamander skin is used as a raw material, only sodium carbonate degreasing and mild pepsin extraction are performed, and then the giant salamander skin non-denatured collagen is obtained. The giant salamander skin non-denatured collagen is compounded with acceptable hydrogel accessories to form a hydrogel dressing with suitable swelling rate and degradability, so that excellent skin repair and anti-aging effects can be achieved without adding exogenous growth factors, and the dressing formula is greatly simplified. Compared with a traditional collagen extraction process, the process is simple, the cost is low, the collagen yield is much higher than that of traditional acid extraction and enzyme extraction methods, and the collagen retention rate can reach more than 90%. Furthermore, the high-value utilization of the giant salamander processing by-products is realized, the raw material source of the functional collagen is expanded, and the economic and environmental values are double.
Owner:JIUYI CHUANGJIA (ZHANGJIAJIE) BIOTECHNOLOGY CO LTD

Black sesame extract freeze-dried powder as well as preparation method and application thereof

PendingCN119607041AHave anti-tumor effectsPowder deliveryFood thermal treatmentBiotechnologyAmylase
The invention relates to the technical field of medicines, in particular to black sesame extract freeze-dried powder as well as a preparation method and application thereof. The preparation method comprises the following steps: frying and crushing black sesame to obtain a black sesame pigment extraction raw material, extracting the black sesame pigment in the black sesame pigment extraction raw material by adopting an alkali-solution and acid-isolation method, uniformly mixing the black sesame pigment with distilled water, further adding an alpha-amylase / calcium chloride solution for incubation, centrifuging, taking supernatant, adjusting the pH value to 1.0-3.0, and filtering to obtain the black sesame pigment. Adding an artificial gastric juice containing 0.01-0.02 g / mL of pepsin, incubating, centrifuging, taking the supernatant, adjusting the pH value, adding an artificial small intestine solution containing 0.01-0.02 g / mL of pancreatin, adjusting the pH value, incubating, centrifuging, taking the supernatant, adjusting the pH value, and freeze-drying to obtain black sesame extract freeze-dried powder; the black sesame extract freeze-dried powder prepared by the invention has an inhibition effect on tumors in a zebra fish PDX model, and can be applied to antitumor drugs or foods.
Owner:GUANGDONG PHARMA UNIV

Packaging straps (pepsin tablets)

ActiveCN309830954SMedicineGastric pepsin
1. Name of the product in this design: Packaging Straps (Pepsin Tablets). 2. Purpose of this design: This product is used for bundling medicine packaging boxes. 3. The key design features of this product are its pattern and the combination of pattern and color. 4. The image or photograph that best illustrates the design's key features: the front view. 5. The design for which protection is sought includes color. 6. This design is for a thin product, therefore the left view, right view, top view, and bottom view are omitted.
Owner:HENAN SHUANGHUI INVESTMENT DEV CO LTD