29 results about "Cardiovascular functions" patented technology

The invention relates to the technical field of cardiovascular medicine, in particular to an automatic alarm system for cardiovascular medicine, which comprises a biomarker analysis module, a physiological parameter analysis module, a cardiovascular risk assessment module, a cardiovascular early warning adjustment module and an alarm trigger notification module. According to the invention, by integrating real-time monitoring of blood biomarkers and cardiovascular physiological parameters, the early recognition capability of cardiovascular disease risks is improved, key biomarkers are dynamically measured and compared with historical marker data, and subtle physiological changes can be captured at the early stage of asymptomatic conditions, so that potential cardiovascular events are warned; through correlation analysis of electrocardiogram, blood pressure and pulse waveforms, the system can accurately draw a comprehensive image of cardiovascular functions, so that more targeted monitoring and intervention are implemented, timeliness and accuracy of medical response are ensured, doctors can formulate targeted monitoring schemes according to real-time data, and the monitoring efficiency is improved. Therefore, deterioration or occurrence of cardiovascular events of patients can be effectively prevented.

The invention relates to the technical field of biological medicines, and provides a novel DELTP polypeptide and application thereof in improving cTnI cardiovascular medicines, and a novel polypeptide and application thereof in medicines for treating cardiovascular diseases. The polypeptide has a unique amino acid sequence and is composed of an amino acid sequence SEQ. NO: 1: Asp-Glu-Leu-Thr-Pro (DELTP), an amino acid sequence SEQ. NO: 2: Arg-His-Met-Ser-Tyr (RHMST) and the like, and the cardiovascular function is improved by adjusting the phosphorylation level of cardiac troponin I (cTnI).

The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart. The system can quantify the functioning of the native heart by measuring certain parameters / signals such as pressure or motor current, then calculate and display one or more metrics of cardiovascular function. These metrics, such as left ventricular end diastolic pressure (LVEDP), left ventricular pressure, and contractility, provide valuable information to a user regarding a patient's state of heart function and recovery.

The invention relates to the technical field of biological medicine, in particular to a novel polypeptide and application thereof in medicine for treating cardiovascular diseases. The polypeptide has a unique amino acid sequence, and is composed of an amino acid sequence of SEQ. NO: 1: Leu-Asn-Pro-Thr-Glu (LNPTG), an amino acid sequence of SEQ. NO: 2: Val-His-Met-Arg-Tyr (VHMRY), and the like. The polypeptide has a unique amino acid sequence, and provides a new way for the treatment of cardiovascular diseases by adjusting the activity of AMPK and improving the cardiovascular function.

The invention discloses an application of a dendrobium extract in preparation of a medicine for treating type 2 diabetes, and mainly relates to the technical field of dendrobium. Particularly, the invention provides the dendrobium extract-containing medicine for treating the type 2 diabetes, so that the stability of components applied to the medicine for treating the type 2 diabetes in acidic, neutral and alkaline environments is improved, and the blood sugar rising amplitude is slowed down. Compared with the prior art, the medicine for treating type 2 diabetes mellitus prepared by the invention takes the dendrobium extract as a core and is matched with the synergistic emulsion, the rhizoma polygonati extract, the dogwood extract, the radix salviae miltiorrhizae extract, the bitter gourd extract, the vitamin B and the trace element chromium element; the traditional Chinese medicine composition disclosed by the invention can be used for synergistically regulating blood sugar metabolism, enhancing insulin sensitivity, improving microcirculation, stabilizing blood sugar, improving insulin resistance and lipid metabolism and enhancing immunity and cardiovascular functions, and a safe and effective medicine is provided for preventing and treating type II diabetes.

The invention discloses a hearing aid health analysis method based on a physiological signal monitoring function. The method comprises the following steps: collecting physiological signal data of a user in real time through a multi-mode biosensor array integrated on a hearing aid body; the hearing aid body comprises a digital signal processor and a wireless communication module; the physiological signal data at least comprises a brain wave signal, a skin electric response signal and a temporal artery pulse signal; performing motion artifact elimination processing on the physiological signal data through an adaptive filtering algorithm; performing feature extraction on the preprocessed physiological signal by using an embedded health analysis engine to generate a composite health feature vector containing a sympathetic nerve activity index, cognitive load measurement and a cardiovascular function index; and dynamically generating a health risk assessment report based on an association relationship between the composite health feature vector and a preset hearing scene, the bone conduction vibration unit and the audio synthesis module of the hearing aid body output graded health alarm signals.

The invention relates to the technical field of cardiovascular function enhancement, and provides a cardiovascular function enhancement device for preventing cardiovascular diseases in order to solve the problems that an existing cardiovascular function enhancement device can only carry out one type of exercise, and the balance weight cannot be adjusted according to personal requirements during training. Comprising a base and a bottom plate arranged on the base, and further comprises a supporting seat arranged on the bottom plate; the load mechanism is arranged above the supporting seat, penetrates through the supporting column and is used for providing a resistance load; the pedal mechanism is arranged in the middle of the base and is used for the patient to tread to generate force to simulate lower limb movement; and the pulley mechanism is used for connecting the pedal mechanism and the load mechanism to realize synchronous matching between the pedal mechanism and the load mechanism. According to the cardiovascular function training device, simulation of multiple motion modes can be provided, and the resistance load can be flexibly adjusted according to personal requirements, so that precise and personalized cardiovascular function training is achieved.

The invention relates to the technical field of biological medicine, in particular to a novel polypeptide and application thereof in medicine for treating cardiovascular diseases. The polypeptide has a unique amino acid sequence and is composed of an amino acid sequence SEQ.NO: 1: Cys-Tyr-Pro-Glu-Arg (CTPER), an amino acid sequence SEQ.NO: 2: Asn-His-Met-Val-Asp (NHVD) and the like, and the cardiovascular function is improved by adjusting a nuclear factor kappa B (NF-kappa B) signal channel.

The application discloses a hearing aid health analysis method based on physiological signal monitoring function, comprising the following steps: collecting physiological signal data of a user in real time through a multi-modal biological sensor array integrated in a hearing aid body; the hearing aid body comprises a digital signal processor and a wireless communication module; the physiological signal data at least comprises an electroencephalogram signal, a galvanic skin response signal and a temporal artery pulse signal; the physiological signal data is subjected to motion artifact elimination processing through an adaptive filtering algorithm; a preprocessed physiological signal is subjected to feature extraction through an embedded health analysis engine, and a composite health feature vector comprising a sympathetic nerve activity index, a cognitive load metric and a cardiovascular function index is generated; a health risk assessment report is dynamically generated based on the association between the composite health feature vector and a preset hearing scene; and a graded health alarm signal is output through a bone conduction vibration unit and an audio synthesis module of the hearing aid body.

The invention relates to the technical field of coenzyme Q10 preparations, and discloses a coenzyme Q10 preparation for improving myocardial cell activity and cardiovascular function, and the coenzyme Q10 preparation comprises the following components in percentage by mass according to 1 liter of prescription: 0.1-10% of coenzyme Q10, 0.5-30% of emulsifier, 5-20% of co-emulsifier, 0.5-10% of stabilizer, 5% of glucose, 0.9% of sodium chloride, 0.25% of absolute ethyl alcohol and the balance of water, according to the coenzyme Q10 preparation for improving the myocardial cell activity and the cardiovascular function, preparation of the coenzyme Q10 preparation is completed, so that the obtained coenzyme Q10 preparation has the functions of enhancing physical ability and vigor, protecting the cardiovascular system, reducing side effects of lipid-lowering drugs, protecting the skin and the like, and the coenzyme Q10 preparation can improve the myocardial function and improve cardiovascular diseases; the heart is prevented from being damaged by oxidative stress.

The invention relates to the technical field of biological medicine, and provides a novel STPEN polypeptide and application thereof to cardiovascular improvement medicine, the polypeptide has a unique amino acid sequence, the polypeptide is composed of amino acid sequences SEQ.NO: 1, Ser-Thr-Pro-Glu-Asn (STPEN) and SEQ.NO: 2, His-Lys-Met-Val-Asp (HKMVD), and the polypeptide is used for adjusting the activity of angiotensin converting enzyme 2 (ACE2), improving the cardiovascular function and improving the cardiovascular function. And a new way is provided for the treatment of cardiovascular diseases.

Methods and systems for assessing cardiovascular functions of a patient are described. The method comprises acquiring ECG data and BIA data concomitantly through a plurality of electrodes positioned in an ECG configuration, predicting parameters of cardiovascular function from the ECG data and the BIA data using deep learning algorithms, and outputting surrogates of parameters of cardiovascular functions in a clinical format.

The invention discloses a composition containing sacubitril-valsartan sodium and fineglitazone and a preparation method thereof, and relates to the technical field of medicines, the composition is composed of sacubitril-valsartan sodium, fineglitazone, a flavoring agent, a taste masking agent, a liposome carrier, a blood vessel protective agent, a synergist, a filler, a disintegrating agent, a lubricant and an adhesive; according to the sacubitril-valsartan sodium tablet and the preparation method thereof, active ingredients of sacubitril sodium and fineglitazone are accurately proportioned, various auxiliary materials such as the flavoring agent, the taste masking agent and the liposome carrier are introduced, the curative effect of the medicine and the medication experience of a patient are greatly improved, sacubitril-valsartan sodium serving as a compound preparation has strong blood pressure lowering and cardiovascular protection effects, and the sacubitril-valsartan sodium tablet is suitable for clinical application. The composition can further improve the cardiovascular function, and the composition and the fipronil have a synergistic effect, so that the composition has excellent performance in the aspect of treating cardiovascular diseases.

The application discloses a coronary heart disease prediction method fusing cardiopulmonary exercise parameter time sequence information, and comprises the following steps: collecting multidimensional health data of a patient; preprocessing the multidimensional health data; extracting features from the preprocessed data; performing time sequence analysis on the extracted features by using a deep learning model; inputting the time sequence analysis result and static features into a classification model to perform coronary heart disease prediction, outputting a prediction result and generating a related health report. By acquiring demographic data, basic medical information and cardiopulmonary exercise test data of a target object, specifically including age, gender, body mass index, socio-economic information, past history, complications, clinical examination and inspection, exercise capacity, cardiovascular function and ventilation perfusion and the like, the coronary heart disease is predicted by fusing static parameters and time sequence information, so that dynamic changes in the health data of the patient can be better captured, and the prediction accuracy is improved.

A system and method for cardiovascular monitoring and reporting are disclosed. The system (CV monitoring system) includes a data analysis system and an in-ear biosensor system that preferably includes left and right earbuds. The earbuds include infrasound / vibration sensors that detect biosignals from the individual including signals associated with cardiovascular activity (CV signals). The analysis system calculates cardiovascular function measurements (CV function measurements) based upon the CV signals. The CV monitoring system uses machine learning to predict blood pressure (BP) measurements of the individual based upon the CV signals and the calculated CV function measurements. In an embodiment, the CV monitoring system includes an EKG detection system that detects EKG signals associated with heart function. The analysis system can calculate additional CV function measurements from the EKG signals to augment the CV function measurements calculated from the CV signals, and predict BP measurements using the full complement of CV function measurements.

The invention discloses a special diet for improving cardiovascular and cerebrovascular diseases and microcirculation disturbance and a preparation method thereof, and the special diet comprises the following components in parts by weight: 2-4 parts of bone collagen peptide, 1-2 parts of taurine, 2-3 parts of hydrolyzed collagen peptide, 1-2 parts of marine fish oligopeptide, 1-2 parts of inulin, 1-2 parts of erythritol, 2-3 parts of acerola cherry fruit powder and 2-3 parts of guarana extract. 1-2 parts of N-acetylneuraminic acid, 1-2 parts of vitamin C, 1-2 parts of vitamin B6, 1-2 parts of vitamin B1 and 1-2 parts of vitamin B2; the traditional Chinese medicine composition can improve cardiovascular functions and microcirculation disturbance, and has remarkable effects in the aspects of inhibiting cardiovascular diseases, promoting microcirculation and enhancing immunity.

This invention in one aspect discloses a smartport system that can continuously monitor cardiovascular function during chemotherapy sessions through ECG and dynamic ejection fraction measurements via ultrasound probes. Ultrasound probes monitor the patency of the catheter shaft through Doppler measurements of the flow. Monitoring heart function and patency of the catheter shaft are unmet needs for chemotherapy patients who receive drugs via portacath systems. This monitoring allows immediate real-time assessment of the cardiotoxicity of cytotoxic chemotherapeutic therapies.

The embodiments disclosed herein can include an operation of receiving a plurality of current cardiovascular function metrics of a patient and a plurality of candidate drugs to be used to reach a plurality of desired cardiovascular function metrics, and an operation of determining an optimal dosage of the plurality of candidate drugs to reach the plurality of desired cardiovascular function metrics. Determining can include optimizing a dosage combination of the plurality of candidate drugs to reach a plurality of desired cardiovascular parameters corresponding to the plurality of desired cardiovascular function metrics from a plurality of current cardiovascular parameters corresponding to the plurality of current cardiovascular function metrics, and mapping a plurality of desired cardiovascular function metrics from the plurality of desired cardiovascular parameters and a plurality of current cardiovascular function metrics from the plurality of current cardiovascular parameters. The operation can further include outputting an optimal dosage of the plurality of candidate drugs.

The invention provides a non-invasive blood pressure waveform reconstruction method based on 3D blood vessel modeling and a depth sequential network, and belongs to the field of non-invasive physiological signal processing and cardiovascular function evaluation. The method comprises the following steps: constructing a physiological simulation model containing a vascular network from a radial artery to a fingertip by adopting VTK; the method comprises the following steps: integrating a Moens-Korteweg wave equation, a vascular compliance model and a Beer-Lambert optical law, and establishing a signal conversion model from ABP to PPG; designing a deep sequential network architecture comprising a U2-Net nested U-shaped structure and a bidirectional time processor (BTP); aBP waveform reconstruction is realized through a depth supervision strategy and a combined loss function; and finally, closed-loop application is realized in a hardware system integrated with the MAX30102 sensor and the STM32F103 processor. Experiments show that according to the method, the prediction precision of SBP 2.48 + / -1.95 mmHg and DBP 1.42 + / -1.42 mmHg is achieved in an MIMICII data set, and the AAMI standard is achieved. Through combination of theoretical modeling and an intelligent algorithm and implementation of a hardware system, a novel noninvasive monitoring scheme is provided for family health monitoring.

1. The name of the design product: High and low oxygen training instrument. 2. The use of the design product: A device for automatically switching between low oxygen and oxygen-rich states, continuously recording patient data, enhancing cardiovascular function, improving physical fitness, etc. 3. The design key points of the design product: lies in the shape. 4. The picture or photo that best shows the design key points: Perspective view 1.

The application discloses a zebrafish cardiovascular function intelligent identification and evaluation method, which comprises the following steps: taking an image of a zebrafish under a microscope, inputting the preprocessed image into a trained zebrafish identification and classification model, filtering out zebrafish images that are not conducive to observation, obtaining a segmentation result of cells or tissues through a zebrafish cell and tissue segmentation model, obtaining information data of blood cell flow rate, heart rate and ejection fraction through a cell tracking algorithm and waveform analysis, and visualizing the cardiovascular function. The method can improve the efficiency of zebrafish experimental data analysis and processing, automatically screen appropriate image data from a large amount of images obtained through experiments, analyze and obtain information data of the cardiovascular function with research value, reduce manual operation, has a simple processing procedure, needs relatively few parameters to be adjusted, and provides strong technical support for zebrafish related research and development of complex cardiovascular disease drugs.

The dalbergia odorifera tea is prepared from Hainan dalbergia odorifera and five cereals (rice, sorghum, wheat, buckwheat and millet), dalbergia odorifera is added, the production method comprises the steps of raw material preparation, mixing, fermentation, distillation, aging and packaging, and active ingredient extraction is optimized. Through the synergistic effect of flavonoid compounds in Hainan dalbergia odorifera, nutritional ingredients of five cereals and the blood activating effect of lignum dalbergiae odoriferae, the cardiovascular function is remarkably improved, and the auxiliary effects of improving sleep, preventing senile dementia, dissolving thrombus and resisting viral pneumonia are achieved.

The present application belongs to the field of medical devices and physiological signal detection technology, and relates to a pulse wave analysis method and system based on piezoelectric dynamics characteristics. The present application compensates for the attenuation of the subcutaneous tissue on the pulse wave through active acoustic detection, emits high-frequency mechanical vibration waves at the end of diastole using multi-frequency voltage pulses, and receives reflected echoes to construct an equivalent acoustic impedance transfer function and an acoustic inverse compensation filter. The present application restores the true arterial vessel wall dynamics by performing frequency domain deconvolution operation on the original pulse wave signal, locates key physiological event points, estimates the local pulse wave propagation speed using a single-point piezoelectric sensor without the need for multi-point measurement. In combination with the fluid mechanics equation, the present application separates the forward incident wave and the backward reflected wave, calculates the absolute amplitude ratio to evaluate the vascular compliance, effectively eliminates the interference of subcutaneous fat and muscle tissue, improves the accuracy and reliability of the evaluation, and provides a new tool for cardiovascular function evaluation.

The invention discloses a bimodal health assessment sensor and method. The device is integrated on a flexible substrate and comprises a sweat microfluidic subsystem, an electrochemical sensing module, a pulse sensing subsystem and an information processing unit. The microfluidic subsystem directionally conveys sweat to the collection cavity through the capillary network; the electrodes of the electrochemical module are arranged along the flow direction of the cavity wall, so that the sweat cortisol is fully detected. The pulse subsystem comprises three flexible pressure sensors matched with the Cun, Guan and Chi point positions of the radial artery. The information processing unit synchronously collects cortisol concentration signals and multi-channel pulse wave signals, and comprehensive health assessment is generated through fusion analysis. The method comprises the steps that bimodal signals are synchronously obtained and processed, pulse features and cortisol dynamic features are extracted and fused, a model is input to obtain a comprehensive index of the cardiovascular function and the emotional pressure, and then dynamic risk assessment and early warning are generated. According to the invention, real-time, continuous and non-invasive comprehensive evaluation of sweat cortisol and pulse waves is realized.

Methods of increasing plasma exposure of Compound (II) in a subject, modulating or enhancing cardiovascular function in said patient or methods of treating an acute, sub-acute, sub-chronic, or chronic disease in a subject in need thereof, comprising administering to a subject an effective amount or formulation of a compound selected from Compound (I) or Compound (II), a pharmaceutically acceptable salt thereof, and an ester thereof. Additionally, this disclosure provides processes for synthesizing enantiomerically enriched salts of Compound (II).

The present application relates to an anti-aging composition for improving cardiovascular function and a preparation method and application thereof, and the composition comprises L-ergothioneine, honokiol, quercetin and coenzyme Q10. The present application creatively designs an anti-aging composition for improving cardiovascular aging, which improves cardiovascular aging from four dimensions of "myocardial energy supply + anti-hypertrophy + endothelial protection + anti-oxidation". Coenzyme Q10 can restore myocardial mitochondrial ATP production, honokiol can reverse myocardial hypertrophy through NAD+ deacetylase, quercetin can improve endothelial function and reduce blood pressure, and L-ergothioneine can protect vascular endothelial cells from oxidative damage and inhibit the formation of ox-LDL. Through research, it is found that the four can cooperate and synergize with each other, and can jointly play an excellent role in improving cardiovascular aging, and achieve multiple protection for cardiovascular aging.

The application discloses application of a dendrobium extract in preparation of a medicine for treating type 2 diabetes, and mainly relates to the technical field of dendrobium. Specifically, the application provides a medicine for treating type 2 diabetes and containing the dendrobium extract, improves stability of components in the medicine for treating type 2 diabetes in an acid, neutral or alkaline environment, and slows down blood sugar increase. Compared with the prior art, the medicine for treating type 2 diabetes prepared by the application takes the dendrobium extract as a core, is matched with a synergistic emulsion, a rhizoma polygonati extract, a fructus corni extract, a salvia miltiorrhiza extract, a momordica charantia extract, vitamin B and trace elements of chromium, and through cooperation with traditional Chinese medicine components, can synergistically regulate blood sugar metabolism, enhance insulin sensitivity and improve microcirculation, can stabilize blood sugar, improve insulin resistance and lipid metabolism, improve immunity and cardiovascular function, and provides a safe and effective medicine for prevention and treatment of type 2 diabetes.

The invention discloses a cardiovascular and cerebrovascular rehabilitation training instrument, and relates to the field of rehabilitation training instruments.The cardiovascular and cerebrovascular rehabilitation training instrument comprises a supporting column, a main body mechanism is fixedly arranged on the supporting column, the main body mechanism comprises a cushion fixedly arranged at the top of the supporting column, and a base is fixedly arranged at the bottom of the supporting column; the device comprises an impedance training mechanism used for carrying out impedance training on legs of a patient suffering from cardiovascular and cerebrovascular diseases, a limiting mechanism used for carrying out limiting supporting on the legs of the patient suffering from cardiovascular and cerebrovascular diseases, a leg physiotherapy mechanism used for carrying out pressing physiotherapy on the legs of the patient suffering from cardiovascular and cerebrovascular diseases, and a sole physiotherapy mechanism used for carrying out knocking massage on soles of the patient suffering from cardiovascular and cerebrovascular diseases. The instrument has the functions of active training and passive physical therapy, the muscle blood pumping capacity can be enhanced through impedance movement, the cardiovascular function can be improved, the legs can be relieved through massage and thermal therapy, blood circulation is promoted, the rehabilitation effect is improved accordingly, and the instrument is suitable for comprehensive rehabilitation training of patients suffering from cardiovascular and cerebrovascular diseases.

The application discloses a physiological signal collection method and device, a wearable device and a storage medium, which can dynamically adjust the physiological signal collection mode, and significantly improve the balance between data quality and device energy efficiency. The application comprises: monitoring the motion state of a user; if the motion state of the user meets a preset static condition, and the current time is within a preset night time period, then the first type of physiological signal and the second type of physiological signal of the user are collected in a continuous sampling mode, the first type of physiological signal is a sensing signal for monitoring cardiovascular function, and the second type of physiological signal is a sensing signal for calculating core body temperature; if the motion state of the user does not meet the preset static condition, and / or the current time is not within the preset night time period, then the first type of physiological signal and the second type of physiological signal of the user are collected in a periodic intermittent sampling mode.