The invention relates to a functional mixture for refreshing and remitting the physical fatigue and the visual fatigue and application thereof. The mixture comprises the components such as taurine, caffeine, green tea extract, American ginseng extract, guarana extract, ginkgo leaf extract, wolfberry extract, lutein, L-carnitine, vitamin B1, nuclear yellow acid, nicotinic acid, vitamin, folic acid, vitamin B, vitamin C, auxiliary materials and the like. The mixture can be used for preparing the functional beverage, the effervescent preparation and the solid beverage electuary. The functional mixture has an application mode which is convenient to carry so as to meet the requirement, has the functions of remitting the physical fatigue and the brain fatigue, adds the nutrients for protecting the vision such as the wolfberry extract and the lutein, is particular suitable for personal who operates a computer for a long time, drivers and students, and plays roles in improving the brain power, protecting the vision, and remitting the physical fatigue and the visual fatigue.