The invention discloses anti-fatigue kidney tonifying health wine and a preparation method for the same. The health wine is prepared by impregnating the following raw materials: 120 to 160 grams of raisin, 120 to 160 grams of black mulberries, 10 to 30 grams of jujubes, 60 to 90 grams of coix seeds, 60 to 90 grams of raspberry, 60 to 90 grams of medlar, 30 to 60 grams of raw hawthorns, 10 to 30 grams of raw licorice, 10 to 30 grams of tangerine peel, 1 to 3 grams of sweet osmanthus, 10 to 30 grams of dark plum fruits, 30 to 60 grams of sugar candies and 15 to 24 grams of white spirit. The health wine has good curative effects on impotence, premature ejaculation and sexual dysfunction, which are caused by liver and kidney deficiency, has good curative effects on subhealthy populations with the symptoms of mental and physical exhaustion, soreness and weakness of waist and knees, joint pain, inappetence, insomnia, amnesia, premature graying of hair and the like, which are caused by life stress, does not contain any hormone, is prepared from pure traditional Chinese medicine, has the effects of refreshing, fatigue resisting, kidney tonifying, beauty keeping and human disease resistance improvement after being drunk for a long time, and is convenient to take, fragrant, sweet and palatable, and a patient often drinking the wine does not feel discomfortable.