The present application belongs to the field of
cosmetics, and provides a long-acting mild anti-
wrinkle supramolecular
polypeptide composition, a preparation method and application thereof. The composition comprises a botulinum-like polypeptide with anti-
wrinkle effect, a polypeptide with the effect of promoting the growth of
skin cell collagen, a polypeptide with the effects of soothing, anti-
allergy and anti-
inflammation, and a supramolecular
ionic liquid with the effect of penetration promotion. The long-acting mild anti-
wrinkle supramolecular composition provided by the present application is centered on the three targets of anti-
skin aging:
smoothing fine lines, tightening
skin and resisting
inflammation, and at the same time, the soothing and anti-
allergy effects which are not possessed by traditional anti-
wrinkle skin care products are taken into account, so as to fully meet the needs of consumers with different skin conditions; on the basis of self-
assembly of polypeptides into supramolecular structures, the stable compounding of 10 kinds of functional polypeptides is completed through a reasonable preparation method and proportion, and the problem of poor compatibility of functional components is solved; on the basis of the supramolecular structure, the supramolecular
ionic liquid is combined for further penetration and delivery, and the synergistic effect also effectively protects the inner supramolecular polypeptide structure.