229 results about "Synergistic combination" patented technology

The invention relates to the technical field of biological medicines and ophthalmic medicines, in particular to a herbal exosome composition for eye care and treatment and a preparation method thereof. The composition comprises a synergistic combination of herbal exosomes and mesenchymal stem cell exosomes, and further comprises a nano slow-release carrier system. Wherein the herbal exosome is extracted from a traditional herbal plant liquorice by combining gradient centrifugation with a molecular exclusion chromatography method, and herbal active ingredients, namely astragaloside and quercetin, are loaded in the exosome by adopting an electroporation method, so that the pharmacological activity of the exosome is enhanced. The nano slow-release carrier system is of a two-phase slow-release structure; an inner phase is a phospholipid complex loaded with herbal exosomes and mesenchymal stem cell exosomes, and an outer phase is temperature-sensitive hydrogel; the compound is in a liquid state at room temperature, and is rapidly converted into a gel state after being dropped into the ocular surface, so that the retention time of the medicine on the ocular surface is remarkably prolonged, the bioavailability is improved, and the targeting slow release capability aiming at ocular surface tissues is endowed to the compound.

The invention belongs to the technical field of cosmetic raw materials, and particularly relates to a plant composition with oil control and acne removal effects and a preparation method and application thereof. The invention provides an oil-controlling and acne-removing plant composition. The oil-controlling and acne-removing plant composition is prepared from a rheum palmatum extract, a scutellaria baicalensis extract, a radix sophorae flavescentis extract, a safflower extract, a campsis grandiflora extract, a chrysanthemum extract, a cockscomb extract and a rose extract in a specific proportion. Through synergistic compatibility of eight plants, the plant composition can effectively inhibit grease synthesis, inflammatory factor expression and propionibacterium acnes growth, so that good oil control and acne removal effects are achieved.

The present invention relates to an oral extract composition comprising Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) extract composition, and its process of preparation. Also relates to the oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient for, improvement, and maintenance of women health more preferably in improving of hot flashes, night sweats, poor sleep, anxiety, sexual dysfunction, mood changes, Genitourinary symptoms in overall improving the quality of life, serum estradiol, progesterone, follicle stimulating hormone (FSH), and cortisol during the period of menopause (perimenopause and menopause). The oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient is used for improving Brain-derived neurotrophic factor (BDNF) levels in women during the period of menopause. The present invention, further related to the extraction process of Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.), also provides the process for the preparation of formulation composition. This invention further relates to the extraction process from Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) either as individual herbs or co-extraction of the two herbs or mixing the extracts at various stages of the individual extracts.

An orally administered composition for treating or reducing damage to connective tissue or for treating or reducing inflammatory symptoms associated with damage to connective tissue includes a synergistic combination of (i) avocado / soybean unsaponifiables; and (ii) a lipoic acid or a salt or derivative thereof. A method for treating or reducing damage to connective tissue, for treating or reducing inflammatory symptoms associated with damage to connective tissue, or for reducing the level of one or more inflammatory mediators in connective tissue includes administering the orally administered composition to an avian or mammalian subject.

Modular multifunctional system, characterized by: a) at least one natural support matrix (module A), b) at least one bioactive component of natural origin (Module B), c) at least one metallic functional element (module C), d) optional synergy-enhancing additions (module D), wherein components b) and c) interact synergistically and together generate functionalities that go beyond the sum of the individual effects.

This invention relates to the field of oil extraction technology, specifically a method for subcritical low-temperature extraction of leek seed oil, comprising the following steps: (1) raw material pretreatment; (2) compound enzymatic hydrolysis cell wall breaking treatment; (3) subcritical low-temperature extraction; (4) integrated gradient low-temperature separation and solvent recovery purification. This invention, through the synergistic combination of raw material low-temperature pretreatment, compound enzymatic hydrolysis directional cell wall breaking, subcritical dynamic countercurrent extraction, and gradient low-temperature separation purification, optimizes the entire process from raw material structure modification, enhanced extraction mass transfer, to efficient product separation, systematically improving the efficiency and quality of leek seed oil preparation. In the raw material stage, hot air low-temperature drying and liquid nitrogen-assisted pulverization are used, which can reduce the moisture content of the raw material and refine the particle size without damaging the intracellular contents, reducing oil oxidation in subsequent processing, while simultaneously improving the enzymatic hydrolysis of the cell wall, laying the foundation for efficient extraction.

The present invention relates to ophthalmic formulations in which a synergistic combination of three different types of disinfectants (a polybiguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound), in particular a combination of polyhexamethylene biguanide, polyquaternium-1 and myristoylaminopropyl dimethylamine, high concentrations of hyaluronates are enabled to provide better comfort and support for corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of hyaluronates at concentrations greater than 7.5 times as high as currently commercially available multi-purpose disinfectants.

The invention discloses equipment and a method for bending an orthodontic steel wire, and aims to solve the contradiction of strength, stability and precision under the working condition of an extremely short discharge head. The equipment comprises a supporting frame, a discharging head assembly, a first clamping mechanism, a second clamping mechanism, a lever adjusting module and a controller. Through the synergistic combination of the length of the discharging head (5-15 mm), the movement included angle of the lever (30-60 degrees) and feeding compensation (0.2-0.6 mm), non-obvious performance improvement is generated. The lever adjusting module drives the chuck to move along an arc track, downward pressure is generated, and a mechanical closed loop of lever motion included angle-downward pressure-load path is formed to resist cutting impact. And the controller executes feeding compensation based on clamping confirmation, so that the precision is ensured. Tests show that when the cooperative system is used for machining typical orthodontic steel wires, the high material utilization rate (larger than or equal to 95%), the high bending precision (the deviation is smaller than or equal to + / -0.5 degrees) and the long service life (larger than or equal to 5000 times) can be achieved, and the performance outside a parameter window is reduced in a cliff mode.

The present composition comprises magnesium-L-threonate and a neurotransmitter such as, but not limited to phosphatidylserine and optionally, at least one of vitamin C, vitamin B6, and vitamin D3. The composition has been shown to increase at least one of memory or cognition in clinical study subjects. The present disclosure is further directed to methods of identifying and a subject with a memory or cognitive deficiency and administering a therapeutically effective amount of a formula comprising magnesium-L-threonate and a neurotransmitter to improve the memory and / or cognitive deficiency. In some implementations, the magnesium-L-threonate is Magtein®. It is also intended that any other neurotransmitter that results in a synergistic composition of the magnesium-L-threonate and the neurotransmitter by administered to improve a subject's memory and / or cognition.

The present application relates to the field of pharmacy, disclose the medicine composition for antibacterial and anti-inflammatory of Chinese herbal medicine and marine extract combination, including: baicalin extract 5~10 parts; andrographolide extract 3~7 parts; sulfated fucoidan 2~5 parts; spongin extract 0.2~1 part; wherein: baicalin extract is derived from the root of scrophulariaceae, is extracted by ethanol-water mixed solvent; andrographolide extract is derived from the whole plant of andrographis, is extracted by ethanol-water mixed solvent; sulfated fucoidan is derived from brown algae, is prepared by enzymolysis and alcohol precipitation method; spongin extract is derived from sponges, is extracted and separated and purified by organic solvent. Through the technical scheme of the synergistic combination of active ingredients of Chinese herbal medicine and marine extract, the technical effect of destroying the biofilm barrier and clearing the stubborn infection focus in the treatment of bacterial vaginitis, candida vaginitis and cervical inflammation associated with biofilm infection is achieved.

The invention relates to the technical field of duck breeding, in particular to a traditional Chinese medicine composition and application thereof in treating riemerella anatipestifer. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3-12 parts of rhizoma coptidis, 3-12 parts of cortex phellodendri, 5-20 parts of cortex fraxini, 8-30 parts of dandelion, 3-12 parts of radix saposhnikoviae, 5-20 parts of fried fructus aurantii, 8-30 parts of fried rhizoma atractylodis macrocephalae and 3-12 parts of liquorice. The novel traditional Chinese medicine composition is obtained through research, the traditional Chinese medicine composition with a better treatment effect on riemerella anatipestifer disease is obtained through synergistic compatibility of all the components, and the traditional Chinese medicine composition has important application value.

This invention provides an oil-purifying cleansing mud and its preparation method. The cleansing mud, by weight, comprises 1-5 parts of a viscosity modifier, 0.01-0.1 parts of a chelating agent, 10-20 parts of a moisturizer, 15-25 parts of a surfactant, 0.1-1 parts of a thickener, 0.1-5 parts of a cleanser, 0.1-2 parts of an antioxidant, 0.1-1 parts of a fragrance, and 50-75 parts of water. The surfactant is a combination of sodium cocoyl glycinate, lauryl hydroxysulfonate betaine, cocoyl glutamic acid, decyl glucoside, potassium cocoyl glycinate, and cetearyl alcohol polyether-25. This oil-purifying cleansing mud, through the use of surfactants, cleansers, and moisturizers, gently cleanses pores, absorbs oil and dirt, and simultaneously soothes the skin, preventing dryness and tightness. The synergistic combination of these components achieves a balance between cleansing, oil removal, and gentleness, precisely regulating the skin's balance and thus enhancing the consumer experience.

Described herein is a synergistic combination comprising a quorum-sensing inhibitor and / or postbiotic metabolite and an antibiotic. Typically, the postbiotic metabolite comprises at least one peptide. Related compositions, uses, and methods are also described, including methods for resensitizing resistant bacteria to an antibiotic, and methods of treating antibiotic-resistant infections, such as methicillin-resistant Staphylococcus aureus (MRSA).

OPAQUE COMPOSITIONS AND METHODS FOR THESE The invention relates to opaque cleaning compositions substantially free of opacifying and pearlescent agents, and associated methods. The cleaning composition may comprise a synergistic combination of a surfactant system and one or more salts. The surfactant system may comprise a nonionic surfactant and two anionic surfactants, and the salt(s) may comprise a multivalent ion. In some examples, the cleaning composition is free of thickeners. Figure for abstract: None

The present invention relates to a pharmaceutical composition for use in the treatment of both low-grade and high-grade glioblastoma in a human subject. The composition comprises a synergistic combination of the following active agents: R-Ketorolac, Bumetanide, and Niflumic acid. This specific combination is designed to exert a synergistic therapeutic effect against glioblastoma by targeting multiple molecular pathways involved in tumor progression, inflammation, and ion transport. In a further aspect of the invention, there is provided a method for selecting a subpopulation of glioblastoma subjects who are responsive to the aforementioned treatment. This method comprises identifying genetic profiles predictive of a favorable therapeutic response to the combined administration of R-Ketorolac, Bumetanide, and Niflumic acid.

The present invention relates to ophthalmic formulations wherein a synergistic combination of three different classes of disinfectants (a multimeric biguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound, in particular a combination of polyhexamethylene biguanide, Polyquaternium-1 and myristamidopropyl dimethylamine) enables the use of high concentrations of hyaluronate for providing better comfort and support of corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of more than 7.5 times higher concentrations of hyaluronate than are present in currently marketed multi-purpose disinfection solutions.

The invention relates to the technical field of microorganisms, in particular to a riemerella anatipestifer bacteriophage as well as a composition and application thereof. The strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) on November 29, 2023, and the preservation number is CGMCC No.45785. The invention further discloses a preparation method of the strain. A composition comprises the bacteriophage and a riemerella anatipestifer inactivated vaccine. The invention discloses a method for quickly establishing immune protection on riemerella anatipestifer in a duck group. An effective amount of the composition is applied to the duck group in need. According to the invention, the specific bacteriophage RDP-RA-22010 and the inactivated vaccine are synergistically compounded, so that the conventional cognition of an immune blank period is broken through. The composition can provide the challenge protection rate up to 90% in the third day after inoculation, while the protection rate of a common vaccine group in the same period is only 40%. And the effective protection time is shortened to 3 days from the traditional 7-14 days. The pathogen inhibition effect and the animal protection rate of the vaccine are far better than the sum of the effects of a phage or a vaccine which are independently used, and reach 1 + 1gt; and 2, synergistic effect.

The invention discloses a high-regeneration-performance absorption liquid for capturing carbon dioxide and a preparation method and application thereof, and relates to the technical field of gas separation and purification, the high-regeneration-performance absorption liquid comprises a main absorption component, an auxiliary absorption component, an active component, an antioxidant, an auxiliary agent and water. According to the absorption liquid provided by the invention, the antioxidant 2, 6-di-tert-butyl-4-methoxyphenol with a specific structure and the auxiliary agent 1-isopropyl-3-pyrrolidinol are introduced and are synergistically combined with the main absorption component, the auxiliary absorption component, the activation component and the solvent water, so that the absorption liquid shows excellent absorption and desorption rate and low-temperature capture performance in a CO2 capture process; the method can obviously reduce the trapping energy consumption and improve the trapping efficiency, so that the operation cost is reduced, and the method is suitable for trapping treatment of CO2-containing waste gas.

This invention relates to the field of epoxy encapsulant technology, and discloses an epoxy encapsulant for sensors and its preparation method. The method includes premixing epoxy resin base material, primary dispersion, secondary mixing, final mixing and degassing, filtration and packaging. Through the synergistic combination of bisphenol A type epoxy resin and phenolic epoxy resin, and the ring-opening reaction with an acid anhydride curing agent, a dense three-dimensional cross-linked network structure is formed, which closes the pores between molecular chains and blocks charge migration paths, thereby improving the electrical insulation performance of the epoxy encapsulant. At the same time, the introduction of polysulfide rubber toughening agent enhances the flexibility and impact resistance of the colloid, improving the reliability of the encapsulation. By using plasma treatment and silane coupling agent surface modification of nano-alumina, the insulation effect is strengthened and the overall mechanical strength of the encapsulant is improved.

The invention relates to the technical field of traditional Chinese medicine preparations, and provides a traditional Chinese medicine composition with acid inhibiting and esophagus protecting effects, which is prepared by compatibility of the following raw material medicines in parts by weight: 6-12 parts of coptis chinensis; 2 to 6 parts of fructus evodiae; 15 to 25 parts of cuttlebone; 10 to 20 parts of inula flower; 15 to 25 parts of ruddle; 12-20 parts of radix paeoniae alba; 8-15 parts of dried orange peel; and 6-10 parts of licorice root. According to the traditional Chinese medicine composition disclosed by the invention, through synergistic compatibility of multiple raw material medicines, the comprehensive efficacy of inhibiting acid, protecting mucous membranes and regulating power is realized, related symptoms are mildly relieved, no adverse reaction exists, and the traditional Chinese medicine composition is suitable for long-term conditioning. The standardized preparation process improves the extraction rate of effective components, ensures the stable and consistent curative effect of the product, overcomes the problems of extensive process and unstable quality of the traditional Chinese medicine preparation, and is suitable for different people, convenient to take, high in compliance, easily available in raw materials, controllable in cost and suitable for industrial production and clinical popularization.

The present invention relates to a synergistic composition for the treatment of disorders related to central nervous system (CNS) excitability. The synergistic composition comprises combination of GABA receptor agonists and synaptic plasticity enhancer or salts thereof along with pharmaceutically acceptable excipients. The GABA receptor agonists are selected from the group consisting of 4-[(2R)-2,4-Dihydroxy-3,3-dimethylbutanamido]butanoic acid, 4- (Pyridine-3-carbonylamino)butanoic acid and 4-(hexadecanoylamino)butanoic acid or salts thereof. The synaptic plasticity enhancer are selected from magnesium 2- acetamidoethanesulfonate, magnesium bis (2-aminoethane-1-sulfonate), magnesium;(2S,3R)- 2,3,4-trihydroxybutanoate, N-(2-Hydroxyethyl)hexadecanamide, 1-(4-aminobutyl)guanidine and 5'-inosinic acid or salts thereof.

The utility model discloses a high-salt antibiotic wastewater treatment device which comprises a DT membrane filtering assembly, a forced crystallization assembly and a crystallized salt separating and drying assembly which are sequentially communicated, the DT membrane filtering assembly is used for filtering and separating wastewater, and the forced crystallization assembly is used for concentrating and crystallizing wastewater. The crystallized salt separating and drying assembly is used for separating and drying crystallized salt, and a salt outlet pipeline of the crystallized salt separating and drying assembly is communicated with the crystallized salt temporary storage device. According to the high-salt antibiotic wastewater treatment device disclosed by the utility model, a process of synergistically combining the DT membrane filtering component, the forced crystallization component and the crystallized salt separating and drying component is adopted, so that sodium chloride in antibiotic wastewater can be continuously, efficiently and quickly separated and purified; the method has the advantages of simple operation process, strong operability and controllability, high recovery rate, and capability of obtaining sodium chloride meeting the standard of being reused for an antibiotic production line, meets the requirements of production and reuse, is energy-saving and environment-friendly, and reduces the operation cost.

The invention relates to the technical field of plant essential oil extraction, and discloses natural acne-removing repair essential oil which is prepared from the following raw materials in percentage by weight: 18-22% of eucalyptus essential oil, 18-22% of cananga odorata essential oil, 18-22% of lavender essential oil, 17-21% of juniper essential oil, 16-20% of cajeput essential oil, 0.5-1.5% of cuba balsam essential oil, 0.5-1.5% of Somasum essential oil and 0.5-1.5% of Roman chamomile essential oil. Through synergistic combination of eucalyptus essential oil, cananga odorata essential oil, lavender essential oil, juniper essential oil, cajeput essential oil, cuba balsam essential oil, Somarie frankincense essential oil and Roman chamomile essential oil, acne removal and repair characteristic integration of the essential oil components is guaranteed, so that the overall efficacy is enhanced.

The invention belongs to the technical field of high polymer materials, and particularly discloses an antibacterial master batch film and a manufacturing device thereof.The antibacterial master batch film comprises, by weight, 70%-90% of a polyethylene base material, 0.1%-1% of an antioxidant, 0.1%-1% of a lubricant and 0.1%-1% of a lubricant, and polyethylene is selected from at least one of low-density polyethylene, linear low-density polyethylene or high-density polyethylene; 10%-30% of an antibacterial composition, wherein the antibacterial composition comprises 30%-50% of nano zinc oxide; 20%-40% of a quaternary ammonium salt compound; 10%-30% of a microcapsule wall material; and 5%-15% of a dispersing agent. The antibacterial master batch film adopts a synergistic combination of nano-zinc oxide and a quaternary ammonium salt compound as an antibacterial agent, and the nano-zinc oxide and the quaternary ammonium salt compound cooperate with each other, so that the antibacterial effect is improved; through microencapsulation treatment, the antibacterial agent is wrapped in the wall material, so that the compatibility with the polyethylene base material is improved, the problem of non-uniform dispersion is solved, the antibacterial agent is protected from being damaged in the processing process, and the durability of the antibacterial effect is prolonged.

The application discloses a mango shoot control and flower promoting PGRs-multifunctional structured molecular additive synergistic composition and application thereof, and belongs to the technical field of mango growth regulation. The composition is composed of five sub-compositions used in stages, each of the sub-compositions containing a plant growth regulator, a nutrient element and a specific structured molecular additive; the structured molecular additive is combined with the plant growth regulator through physical embedding, electrostatic adsorption or hydrophobic interaction. The application also provides an application method of the composition, including two stages of soil shoot control and leaf surface regulation. Through construction of an intelligent delivery system, the application realizes environment-responsive release, slow release and targeted delivery of active ingredients, effectively solves technical bottlenecks of poor stability, low targeting and high residual risk of traditional plant growth regulators, can accurately regulate the growth cycle of mangoes, significantly improves yield and quality, and greatly reduces pesticide residues and environmental load.

The present invention relates to synergistic combinations of DNA-alkylating ADCs and ATR inhibitors.

The invention relates to the technical field of daily chemical products, and provides an oxygen-enriched olive oil and DHA compounded whitening and repairing composition as well as a preparation method and application thereof, and the composition comprises DHA and oxygen-enriched olive oil in a mass ratio of 1: (1-100). By optimizing the ratio of the DHA to the oxygen-enriched olive oil, the synergistic combination of the excellent oxidation resistance of the DHA and the tissue repair and barrier conditioning capability of the oxygen-enriched olive oil is realized, the tyrosinase expression is down-regulated, the skin repair function is enhanced, the melanin degradation is promoted, and a good application prospect is achieved.

Compositions of nanoparticles and surfactants for improved water injectivity are disclosed. More specifically, synergistic combination of nanoparticles, including amine functionalized colloidal nanoparticles and surfactants, provides enhanced water injectivity and increased oil production. Methods of using are also disclosed.

This invention provides a mesoporous carbon material, its preparation method, and its applications. The preparation method includes the following steps: mixing a carbon source, a solvent, and a surfactant to obtain a slurry with a viscosity of 2.98 × 10⁻³ Pa·s to 20 Pa·s; subjecting the slurry to evaporation-induced self-assembly to obtain a mesoporous carbon precursor material; and extracting and carbonizing the mesoporous carbon precursor material with the surfactant to obtain the mesoporous carbon material. The preparation method provided by this invention, through the synergistic combination of a high-viscosity slurry and a surfactant extraction scheme, enables the large-scale production of mesoporous carbon materials prepared by the EISA method, while also effectively recovering the surfactant, avoiding waste of raw materials and reducing preparation costs; and yielding a mesoporous carbon material with a highly ordered pore structure, a large specific surface area, and good thermal and chemical stability.

The invention discloses a preparation process of a composite VOCs catalytic purification material for an air conditioner and an air conditioner filter screen, and the preparation process comprises the following steps: (1) mixing alpha-MnO2, delta-MnO2 and MnCuOx to obtain mixed powder; the content of the alpha-MnO2 is 10 to 70 parts by weight, the content of the delta-MnO2 is 15 to 70 parts by weight, and the content of the MnCuOx is 15 to 70 parts by weight; (2) adding a binder into the mixed powder to prepare slurry; and (3) coating the surface of a carrier with the slurry, and drying and curing to obtain the composite VOCs catalytic purification material. According to the method, VOCs are adsorbed and enriched through the high specific surface area of alpha-MnO2, formaldehyde is directionally activated through oxygen-enriched vacancies of delta-MnO2, and benzene series are activated through MnCuOx copper-doped lattice distortion, so that the limitation of a traditional manganese-based catalyst on the activation energy barrier of the benzene series is broken through, and meanwhile, the problem of efficiency attenuation is solved.