325 results about "Synergistic combination" patented technology

The invention belongs to the technical field of metallurgical continuous casting, and particularly relates to a method for removing tundish inclusions based on cooperation of an external electric field and physics. The invention discloses a method for removing tundish inclusions based on cooperation of an external electric field and physics, and mainly aims at solving the problems that as the inclusions in tundish molten steel enter a subsequent continuous casting link, a submersed nozzle is clogged and blocked, and the quality of a casting blank is deteriorated. The key point is that an external electric field and physics synergistic effect is used; a bottom blowing device is arranged to provide power for floating of inclusions; an original baffle weir structure of the tundish is improved, and the probability of catching inclusions is increased; and an external electric field is cooperatively used, so that the inclusions are promoted to float towards the tundish covering agent and be attached to the blocking weir. By means of the method for cooperatively removing the tundish inclusions based on the external electric field and physics, the tundish molten steel inclusions can be obviously removed, the service performance of a subsequent water gap is optimized, the casting blank quality is improved, and the improvement of the high-quality steel smelting level in China is assisted.

The invention relates to the technical field of whitening essence, and discloses whitening essence suitable for sensitive skin and a preparation method thereof.The whitening essence suitable for sensitive skin is prepared from, by mass, 2%-3% of prinsepia utilis royle oil, 1%-2% of portulaca oleracea extract, 1.5% of camellia yunnanensis flower extract, 0.5% of panax notoginseng root extract, 3% or less of nicotinamide, 1% or less of 1, 2-propylene glycol and the balance deionized water. 1%-1.5% of 1, 2-hexanediol, 0.1%-0.3% of sodium hyaluronate and 60%-70% of deionized water. According to the whitening essence suitable for the sensitive skin and the preparation method of the whitening essence, through the synergistic combination of prinsepia utilis royle oil (barrier repair), purslane (anti-inflammatory), camellia japonica (tyrosinase inhibition) and pseudo-ginseng (microcirculation improvement), melanogenesis is inhibited through multiple channels, the sensitive skin is relieved synchronously, nicotinamide (3%) is compounded with the prinsepia utilis royle oil, and the skin whitening effect is achieved. The synergism of whitening and barrier repair is enhanced through a dual mechanism of promoting ceramide synthesis and inhibiting melanin transport, and the problems that a traditional whitening agent has different degrees of irritation, allergy phenomena such as skin redness, swelling and pain are easily caused by improper use, and a skin intolerance phenomenon exists are solved.

The invention relates to a water jet-laser / mechanical energy field cooperative precision machining method for a ceramic base material, and belongs to the field of laser-mechanical cooperative machining. During the execution period, the method comprises the following steps in sequence: firstly, carrying out rapid and low-damage precise material reduction on the ceramic matrix composite material through water jet assisted laser; and then, a superhard forming grinding wheel on the same machine tool is matched with mixed grinding fluid to conduct in-situ finishing and polishing on the surface obtained after material reduction. Wherein the surface quality can be improved while high-efficiency machining is ensured through the synergistic combination of laser and machinery. Through the in-situ grinding and polishing effect of the grinding wheel and the mixed grinding fluid, the precision of a formed surface is higher, and a damaged layer is thinner and even completely removed. Based on a water jet assisted laser milling / mechanical grinding and polishing collaborative machining strategy, rough machining, finish machining and fine polishing of the ceramic matrix composite can be completed on the same equipment, and the method has the characteristics of being high in precision, high in efficiency, high in quality and extremely low in surface damage.

The invention discloses a natural component composition for conditioning skin micro-ecology, a preparation method of the natural component composition and application of the natural component composition in skin care products for children. The composition comprises a synergistic combination of a sphingomonas fermentation product extract, a haematococcus pluvialis extract rich in astaxanthin, an abelmoschus esculentus fruit extract rich in polysaccharides, and a yeast / zinc fermentation product. The present invention provides improvements in astaxanthin in terms of chemical stability and transdermal permeability. The composition aims to enhance the immature skin barrier, provide a good effect, and support the healthy development of skin microecology, thereby solving the unique physiological needs of children's skin. The invention also describes a preparation method of the composition and application of the composition in cosmetics for children and dermatological products.

The present invention relates to a dispersant for graphite and graphene and its application. The composition is a synergistic combination of alkyl sulfosuccinate and polyalkylene glycol. Appropriate adding amount thereof can quickly and easily disperse graphite and graphene in the medium, improve its dispersion uniformity and stability, delay its sedimentation, and inhibit its re-accumulation. Furthermore, the present invention can apply graphite and graphene to other media besides non-water-based or organic solvents. The composition of the present invention does not contain flammable volatile chemicals, any fluorine-, silicon- or phosphorus-based compounds, or any aromatic substances. The present invention can not only reduce environmental pollution but also improve the operational safety of relevant personnel.

The invention belongs to the technical field of coatings, and discloses a preparation method and application of a low-temperature fast-curing coiled material powder coating, and the preparation method comprises the following steps: S1, adding raw materials of the low-temperature fast-curing coiled material powder coating into a high-speed mixer, and mixing for 5-8 minutes at the rotating speed of 1200-1600r / min to ensure that the components are uniformly dispersed; s2, adding the mixture into a double-screw extruder for melt extrusion, wherein the temperature of the double-screw extruder is 80-90 DEG C in a first area, 100-110 DEG C in a second area, 120-130 DEG C in a third area and 110-120 DEG C in a fourth area, and the rotating speed is 200-250 r / min; s3, tabletting and cooling to 40 DEG C or below, after coarse crushing, adopting an ACM pulverizer and a grading screen of 80-120 meshes to obtain the low-temperature fast-curing coiled material powder coating, low-temperature curing and fast film forming are achieved through component cooperation, the process adaptability is high, meanwhile, functional filler modified sericite and modified nanometer aluminum oxide are added, and the low-temperature fast-curing coiled material powder coating is prepared. The two synergistically enhance the corrosion resistance, mechanical strength and environmental adaptability of the powder coating paint film.

The invention relates to the technical field of biological medicines and ophthalmic medicines, in particular to a herbal exosome composition for eye care and treatment and a preparation method thereof. The composition comprises a synergistic combination of herbal exosomes and mesenchymal stem cell exosomes, and further comprises a nano slow-release carrier system. Wherein the herbal exosome is extracted from a traditional herbal plant liquorice by combining gradient centrifugation with a molecular exclusion chromatography method, and herbal active ingredients, namely astragaloside and quercetin, are loaded in the exosome by adopting an electroporation method, so that the pharmacological activity of the exosome is enhanced. The nano slow-release carrier system is of a two-phase slow-release structure; an inner phase is a phospholipid complex loaded with herbal exosomes and mesenchymal stem cell exosomes, and an outer phase is temperature-sensitive hydrogel; the compound is in a liquid state at room temperature, and is rapidly converted into a gel state after being dropped into the ocular surface, so that the retention time of the medicine on the ocular surface is remarkably prolonged, the bioavailability is improved, and the targeting slow release capability aiming at ocular surface tissues is endowed to the compound.

The invention relates to the technical field of cable sheath preparation, and discloses a cable sheath which comprises the following components in parts by weight: basic rubber materials: vinyl-terminated methyl vinyl silicone rubber and crosslinked polyethylene; the synergistic flame-retardant system is prepared from zinc borate, ammonium polyphosphate, melamine, pentaerythritol and composite modified nano montmorillonite; the nano composite additive is prepared from nano silicon dioxide, nano zinc oxide, nano boron nitride and graphene; an interface compatilizer: maleic anhydride grafted polyethylene; according to the invention, through component optimization and synergistic cooperation, on the premise of not depending on a halogen flame retardant, high flame retardance, excellent mechanical properties and stable aging resistance are realized at the same time, and strict requirements of high-end cables on safety and reliability are met. Besides, the material preparation process is simple and controllable, is suitable for large-scale production, and can be widely applied to the fields of high-rise buildings, rail transit, new energy and the like with high requirements on the performance of the cable sheath.

The invention belongs to the technical field of cosmetic raw materials, and particularly relates to a plant composition with oil control and acne removal effects and a preparation method and application thereof. The invention provides an oil-controlling and acne-removing plant composition. The oil-controlling and acne-removing plant composition is prepared from a rheum palmatum extract, a scutellaria baicalensis extract, a radix sophorae flavescentis extract, a safflower extract, a campsis grandiflora extract, a chrysanthemum extract, a cockscomb extract and a rose extract in a specific proportion. Through synergistic compatibility of eight plants, the plant composition can effectively inhibit grease synthesis, inflammatory factor expression and propionibacterium acnes growth, so that good oil control and acne removal effects are achieved.

A flame retardant polyamide composition comprising a synergistic combination of an epoxy terminated brominated epoxy polymer and a tribromophenol terminated brominated epoxy polymer. The polyamide composition has excellent heat resistance and good elongation at break properties without the presence of decabromodiphenylethane.

The present invention relates to an oral extract composition comprising Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) extract composition, and its process of preparation. Also relates to the oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient for, improvement, and maintenance of women health more preferably in improving of hot flashes, night sweats, poor sleep, anxiety, sexual dysfunction, mood changes, Genitourinary symptoms in overall improving the quality of life, serum estradiol, progesterone, follicle stimulating hormone (FSH), and cortisol during the period of menopause (perimenopause and menopause). The oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient is used for improving Brain-derived neurotrophic factor (BDNF) levels in women during the period of menopause. The present invention, further related to the extraction process of Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.), also provides the process for the preparation of formulation composition. This invention further relates to the extraction process from Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) either as individual herbs or co-extraction of the two herbs or mixing the extracts at various stages of the individual extracts.

This invention relates to a synergistic composition comprising combination of palmitoylethanolamide, Acetyl carnitine, and uridine, or their pharmaceutically acceptable salts, derivatives, isomers, or deacetylated form thereof for controlling neuromuscular pain and repairing nerve damage. The present invention provides a synergistic composition for the management of nerve health. The invention specifically provides a composition that exhibits a synergistic effect and demonstrates therapeutic effectiveness comparable to standard chemical drug.

The present invention relates to a composition containing (a) a guanidine and / or an unsubstituted guanidine salt, and (b) at least one further component selected from the group consisting of 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, 1, 2-benzisothiazolin-3-one, N-butyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, the cleaning agent is prepared from 2-benzisothiazolin-3-one, octyl isothiazolinone, bronopol, dibromo-nitrilopropionamide, dibromo-dicyanobutane, butyl carbamic acid iodopropynyl ester, aminomethyl propanol, aminoethyl propylene glycol, monoethanolamine, ethylhexylglycerin, hexylglycerin, 1, 2-pentanediol, 1, 2-hexanediol, 1, 2-heptanediol, 1, 2-octylene glycol, phenoxy ethanol and phenethyl alcohol. The cleaning agent is prepared from phenyl propanol, benzyl alcohol, isopropanol, ethylenediamine tetraacetic acid, (1-hydroxyethylidene) diphosphonic acid, 2-mercaptopyridine sodium oxide, 2-mercaptopyridine zinc oxide, o-phenylphenol, sorbic acid, benzoic acid, salicylic acid, lactic acid, citric acid and zinc. The invention also relates to an industrial product containing components (a) and (b), and to the use of said composition for the preservation of containers and for the preservation of industrial products. The invention also relates to the use of (a) a guanidine and / or an unsubstituted guanidine salt for improving the antimicrobial efficacy of one or more compounds selected from the group (b) described above.

Provided are methods for treating a disease or condition associated with reduced autophagy in a patient, which includes administering to the patient, either simultaneously or sequentially, a therapeutically effective amount of a synergistic combination of compounds from at least two and preferably three of the classes of compounds selected from a saccharide, a vitamin, a ketone body, a polyphenol, and a methylxanthine. The compounds may be present in a subtherapeutic effective amount relative to the compound's dosing when given as a single agent. Also provided are pharmaceutically acceptable compositions and kits including at least two and preferably three of the named classes of compounds.

The present invention relates to the field of pesticide technology, and more specifically to a fungicide composition that improves the effectiveness of preventing and treating jackfruit fruit rot. The fungicide composition, comprising a compound of farnesol and cyproconazole as active ingredients; the mass ratio of farnesol to cyproconazole is 1-9:5-1. Based on existing pesticides, the present invention compounds different active ingredients of pesticides to screen for synergistic combinations. This combination can improve the effectiveness of preventing and treating jackfruit fruit rot, reduce pesticide application dosage, and delay the development of drug resistance in pathogens.

An orally administered composition for treating or reducing damage to connective tissue or for treating or reducing inflammatory symptoms associated with damage to connective tissue includes a synergistic combination of (i) avocado / soybean unsaponifiables; and (ii) a lipoic acid or a salt or derivative thereof. A method for treating or reducing damage to connective tissue, for treating or reducing inflammatory symptoms associated with damage to connective tissue, or for reducing the level of one or more inflammatory mediators in connective tissue includes administering the orally administered composition to an avian or mammalian subject.

Methods and compositions promote weight loss in mammals, such as in humans and / or animals, such as, for example, pets. Specifically, the methods and compositions herein promote weight loss due to the production of appetite-suppressing gut hormones, increased metabolism, reduced fat and carbohydrate absorption, and reduced fat deposition through the synergistic combination of fibers and botanical extracts. Food products comprising the compositions herein provide a natural and effective means of controlling appetite and managing weight.

Modular multifunctional system, characterized by: a) at least one natural support matrix (module A), b) at least one bioactive component of natural origin (Module B), c) at least one metallic functional element (module C), d) optional synergy-enhancing additions (module D), wherein components b) and c) interact synergistically and together generate functionalities that go beyond the sum of the individual effects.

This invention relates to the field of oil extraction technology, specifically a method for subcritical low-temperature extraction of leek seed oil, comprising the following steps: (1) raw material pretreatment; (2) compound enzymatic hydrolysis cell wall breaking treatment; (3) subcritical low-temperature extraction; (4) integrated gradient low-temperature separation and solvent recovery purification. This invention, through the synergistic combination of raw material low-temperature pretreatment, compound enzymatic hydrolysis directional cell wall breaking, subcritical dynamic countercurrent extraction, and gradient low-temperature separation purification, optimizes the entire process from raw material structure modification, enhanced extraction mass transfer, to efficient product separation, systematically improving the efficiency and quality of leek seed oil preparation. In the raw material stage, hot air low-temperature drying and liquid nitrogen-assisted pulverization are used, which can reduce the moisture content of the raw material and refine the particle size without damaging the intracellular contents, reducing oil oxidation in subsequent processing, while simultaneously improving the enzymatic hydrolysis of the cell wall, laying the foundation for efficient extraction.

The present invention relates to ophthalmic formulations in which a synergistic combination of three different types of disinfectants (a polybiguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound), in particular a combination of polyhexamethylene biguanide, polyquaternium-1 and myristoylaminopropyl dimethylamine, high concentrations of hyaluronates are enabled to provide better comfort and support for corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of hyaluronates at concentrations greater than 7.5 times as high as currently commercially available multi-purpose disinfectants.

The invention discloses equipment and a method for bending an orthodontic steel wire, and aims to solve the contradiction of strength, stability and precision under the working condition of an extremely short discharge head. The equipment comprises a supporting frame, a discharging head assembly, a first clamping mechanism, a second clamping mechanism, a lever adjusting module and a controller. Through the synergistic combination of the length of the discharging head (5-15 mm), the movement included angle of the lever (30-60 degrees) and feeding compensation (0.2-0.6 mm), non-obvious performance improvement is generated. The lever adjusting module drives the chuck to move along an arc track, downward pressure is generated, and a mechanical closed loop of lever motion included angle-downward pressure-load path is formed to resist cutting impact. And the controller executes feeding compensation based on clamping confirmation, so that the precision is ensured. Tests show that when the cooperative system is used for machining typical orthodontic steel wires, the high material utilization rate (larger than or equal to 95%), the high bending precision (the deviation is smaller than or equal to + / -0.5 degrees) and the long service life (larger than or equal to 5000 times) can be achieved, and the performance outside a parameter window is reduced in a cliff mode.

The present composition comprises magnesium-L-threonate and a neurotransmitter such as, but not limited to phosphatidylserine and optionally, at least one of vitamin C, vitamin B6, and vitamin D3. The composition has been shown to increase at least one of memory or cognition in clinical study subjects. The present disclosure is further directed to methods of identifying and a subject with a memory or cognitive deficiency and administering a therapeutically effective amount of a formula comprising magnesium-L-threonate and a neurotransmitter to improve the memory and / or cognitive deficiency. In some implementations, the magnesium-L-threonate is Magtein®. It is also intended that any other neurotransmitter that results in a synergistic composition of the magnesium-L-threonate and the neurotransmitter by administered to improve a subject's memory and / or cognition.

The present application relates to the field of pharmacy, disclose the medicine composition for antibacterial and anti-inflammatory of Chinese herbal medicine and marine extract combination, including: baicalin extract 5~10 parts; andrographolide extract 3~7 parts; sulfated fucoidan 2~5 parts; spongin extract 0.2~1 part; wherein: baicalin extract is derived from the root of scrophulariaceae, is extracted by ethanol-water mixed solvent; andrographolide extract is derived from the whole plant of andrographis, is extracted by ethanol-water mixed solvent; sulfated fucoidan is derived from brown algae, is prepared by enzymolysis and alcohol precipitation method; spongin extract is derived from sponges, is extracted and separated and purified by organic solvent. Through the technical scheme of the synergistic combination of active ingredients of Chinese herbal medicine and marine extract, the technical effect of destroying the biofilm barrier and clearing the stubborn infection focus in the treatment of bacterial vaginitis, candida vaginitis and cervical inflammation associated with biofilm infection is achieved.

The invention relates to the technical field of duck breeding, in particular to a traditional Chinese medicine composition and application thereof in treating riemerella anatipestifer. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3-12 parts of rhizoma coptidis, 3-12 parts of cortex phellodendri, 5-20 parts of cortex fraxini, 8-30 parts of dandelion, 3-12 parts of radix saposhnikoviae, 5-20 parts of fried fructus aurantii, 8-30 parts of fried rhizoma atractylodis macrocephalae and 3-12 parts of liquorice. The novel traditional Chinese medicine composition is obtained through research, the traditional Chinese medicine composition with a better treatment effect on riemerella anatipestifer disease is obtained through synergistic compatibility of all the components, and the traditional Chinese medicine composition has important application value.

This invention provides an oil-purifying cleansing mud and its preparation method. The cleansing mud, by weight, comprises 1-5 parts of a viscosity modifier, 0.01-0.1 parts of a chelating agent, 10-20 parts of a moisturizer, 15-25 parts of a surfactant, 0.1-1 parts of a thickener, 0.1-5 parts of a cleanser, 0.1-2 parts of an antioxidant, 0.1-1 parts of a fragrance, and 50-75 parts of water. The surfactant is a combination of sodium cocoyl glycinate, lauryl hydroxysulfonate betaine, cocoyl glutamic acid, decyl glucoside, potassium cocoyl glycinate, and cetearyl alcohol polyether-25. This oil-purifying cleansing mud, through the use of surfactants, cleansers, and moisturizers, gently cleanses pores, absorbs oil and dirt, and simultaneously soothes the skin, preventing dryness and tightness. The synergistic combination of these components achieves a balance between cleansing, oil removal, and gentleness, precisely regulating the skin's balance and thus enhancing the consumer experience.

Described herein is a synergistic combination comprising a quorum-sensing inhibitor and / or postbiotic metabolite and an antibiotic. Typically, the postbiotic metabolite comprises at least one peptide. Related compositions, uses, and methods are also described, including methods for resensitizing resistant bacteria to an antibiotic, and methods of treating antibiotic-resistant infections, such as methicillin-resistant Staphylococcus aureus (MRSA).

OPAQUE COMPOSITIONS AND METHODS FOR THESE The invention relates to opaque cleaning compositions substantially free of opacifying and pearlescent agents, and associated methods. The cleaning composition may comprise a synergistic combination of a surfactant system and one or more salts. The surfactant system may comprise a nonionic surfactant and two anionic surfactants, and the salt(s) may comprise a multivalent ion. In some examples, the cleaning composition is free of thickeners. Figure for abstract: None

The present invention relates to a pharmaceutical composition for use in the treatment of both low-grade and high-grade glioblastoma in a human subject. The composition comprises a synergistic combination of the following active agents: R-Ketorolac, Bumetanide, and Niflumic acid. This specific combination is designed to exert a synergistic therapeutic effect against glioblastoma by targeting multiple molecular pathways involved in tumor progression, inflammation, and ion transport. In a further aspect of the invention, there is provided a method for selecting a subpopulation of glioblastoma subjects who are responsive to the aforementioned treatment. This method comprises identifying genetic profiles predictive of a favorable therapeutic response to the combined administration of R-Ketorolac, Bumetanide, and Niflumic acid.

The present invention relates to ophthalmic formulations wherein a synergistic combination of three different classes of disinfectants (a multimeric biguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound, in particular a combination of polyhexamethylene biguanide, Polyquaternium-1 and myristamidopropyl dimethylamine) enables the use of high concentrations of hyaluronate for providing better comfort and support of corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of more than 7.5 times higher concentrations of hyaluronate than are present in currently marketed multi-purpose disinfection solutions.

The invention relates to the technical field of microorganisms, in particular to a riemerella anatipestifer bacteriophage as well as a composition and application thereof. The strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) on November 29, 2023, and the preservation number is CGMCC No.45785. The invention further discloses a preparation method of the strain. A composition comprises the bacteriophage and a riemerella anatipestifer inactivated vaccine. The invention discloses a method for quickly establishing immune protection on riemerella anatipestifer in a duck group. An effective amount of the composition is applied to the duck group in need. According to the invention, the specific bacteriophage RDP-RA-22010 and the inactivated vaccine are synergistically compounded, so that the conventional cognition of an immune blank period is broken through. The composition can provide the challenge protection rate up to 90% in the third day after inoculation, while the protection rate of a common vaccine group in the same period is only 40%. And the effective protection time is shortened to 3 days from the traditional 7-14 days. The pathogen inhibition effect and the animal protection rate of the vaccine are far better than the sum of the effects of a phage or a vaccine which are independently used, and reach 1 + 1gt; and 2, synergistic effect.