479 results about "Synergistic combination" patented technology

A synergistic composition for improving the bioaccessibility of minerals comprises lutein, a casein phosphopeptide, or a 1, 3-dioleoyl-2-palmitic acid triglyceride, preferably in combination with one or more non-digestible oligosaccharides. These compositions are useful for the prevention and / or treatment of mineral deficiency and related conditions, preferably anemia, said minerals comprising iron and / or calcium.

The invention belongs to the technical field of metallurgical continuous casting, and particularly relates to a method for removing tundish inclusions based on cooperation of an external electric field and physics. The invention discloses a method for removing tundish inclusions based on cooperation of an external electric field and physics, and mainly aims at solving the problems that as the inclusions in tundish molten steel enter a subsequent continuous casting link, a submersed nozzle is clogged and blocked, and the quality of a casting blank is deteriorated. The key point is that an external electric field and physics synergistic effect is used; a bottom blowing device is arranged to provide power for floating of inclusions; an original baffle weir structure of the tundish is improved, and the probability of catching inclusions is increased; and an external electric field is cooperatively used, so that the inclusions are promoted to float towards the tundish covering agent and be attached to the blocking weir. By means of the method for cooperatively removing the tundish inclusions based on the external electric field and physics, the tundish molten steel inclusions can be obviously removed, the service performance of a subsequent water gap is optimized, the casting blank quality is improved, and the improvement of the high-quality steel smelting level in China is assisted.

The invention discloses a firming and anti-wrinkle composition and application thereof, and belongs to the field of cosmetics. The composition comprises the following raw materials: a tuber melanosporum extract, a dendrobium officinale extract, a polyrock extract and a swertia indica extract, and the raw materials are synergistically compounded, so that the composition provided by the invention has remarkable tightening and anti-wrinkle effects.

The invention relates to the technical field of whitening essence, and discloses whitening essence suitable for sensitive skin and a preparation method thereof.The whitening essence suitable for sensitive skin is prepared from, by mass, 2%-3% of prinsepia utilis royle oil, 1%-2% of portulaca oleracea extract, 1.5% of camellia yunnanensis flower extract, 0.5% of panax notoginseng root extract, 3% or less of nicotinamide, 1% or less of 1, 2-propylene glycol and the balance deionized water. 1%-1.5% of 1, 2-hexanediol, 0.1%-0.3% of sodium hyaluronate and 60%-70% of deionized water. According to the whitening essence suitable for the sensitive skin and the preparation method of the whitening essence, through the synergistic combination of prinsepia utilis royle oil (barrier repair), purslane (anti-inflammatory), camellia japonica (tyrosinase inhibition) and pseudo-ginseng (microcirculation improvement), melanogenesis is inhibited through multiple channels, the sensitive skin is relieved synchronously, nicotinamide (3%) is compounded with the prinsepia utilis royle oil, and the skin whitening effect is achieved. The synergism of whitening and barrier repair is enhanced through a dual mechanism of promoting ceramide synthesis and inhibiting melanin transport, and the problems that a traditional whitening agent has different degrees of irritation, allergy phenomena such as skin redness, swelling and pain are easily caused by improper use, and a skin intolerance phenomenon exists are solved.

The invention relates to a fluxazole amide composition and a preparation method thereof. More specifically, the present invention relates to synergistic compositions of fluoxazole amides and methods of preparing stable and non-phytotoxic formulations, the synergistic composition comprises fluoxazole amide or an agrochemically acceptable salt thereof, an insecticide selected from diamides, at least one or more compounds selected from insecticides, fungicides and plant health additives, and an agrochemically acceptable excipient. The invention further relates to pesticidal compositions for controlling harmful pests in plants, which can be formulated, are environmentally safe, exhibit high efficacy, and act on disease resistance management or delay the development of disease resistance by employing a variety of modes of action, plant tolerance against insect pests, mites, fungal and bacterial diseases and abiotic stress is increased and the overall health and vigor of the treated plant is improved.

The present invention is in the field of antioxidants and relates to cosmetic or pharmaceutical, preferably dermatological, compositions or homecare product comprising or consisting of a synergistic combination of a specific antioxidant and an effective amount of 1,2-heptanediol and / or 2,3-heptanediol or of a specific alkanediol or a mixture of two or more different specific alkanediols and the use of said compositions as a cosmetic, for personal care, as a pharmaceutical or homecare product, in particular for scavenging reactive oxygen species (ROS), for inhibition matrix metalloproteinases expression and / or for inhibiting interleukin 8 (IL-8) secretion. Additionally, the present invention relates to the use of 1,2-heptanediol and / or 2,3-heptanediol or of a specific alkanediol or a mixture of two or more different specific alkanediols for enhancing the antioxidative effect of an antioxidant in a cosmetic or pharmaceutical, preferably dermatological, composition or homecare product, and / or for enhancing the antioxidative effect of a cosmetic or pharmaceutical, preferably dermatological, composition upon application.

The invention discloses SnCu alloy laser soldering paste and a preparation method thereof.The raw materials of the SnCu alloy laser soldering paste comprise soldering powder and flux paste, the soldering powder comprises Cu-coated Sn metal powder and silver metal powder, and the flux paste comprises Cu-coated Sn metal powder and silver metal powder; the flux paste comprises modified rosinyl carboxylic acid, a modified rosinyl acrylate polymer, a solvent, a wetting agent, organic amine, an anti-oxidation and anti-tarnishing agent and a thixotropic agent. According to the SnCu alloy laser soldering paste, wetting and diffusion of alloy powder can be effectively promoted through cooperation of all the components, and meanwhile oxidation and pollution in the welding process are reduced; the method can be widely applied to the fields of consumer electronics precision assembly, automotive electronics high-reliability welding, new energy equipment packaging, medical / aerospace extreme environment devices, optical communication core modules, industrial precision devices and the like, and micron-sized precise welding, high-reliability connection and the like are achieved.

Novel, inexpensive, and highly effective methods and devices for convenient and effective wound irrigation are described herein. Methods and devices disclosed herein utilize a synergistic combination of two or more antiseptic agents to reduce contact time, enhance antimicrobial effects, and reduce the likelihood of allergy and other side effects from the antiseptic agents in subjects. In one embodiment, devices include a discharge means for a reservoir housing containing irrigation solution wherein the discharge means has one or more specifically designed nozzles through which a sufficient volume of the irrigation solution can pass at an appropriate pressure.

The invention provides heat-conducting silicone grease as well as a preparation method and application thereof, and preparation raw materials of the heat-conducting silicone grease comprise the following components in parts by weight: 12-20 parts of organic silicone oil; 2-5 parts of a silane coupling agent; 0.2 to 0.5 part of a powder treating agent; 150 to 200 parts of heat conduction powder; the silane coupling agent comprises a single terminal alkoxy type silane coupling agent; the heat-conducting powder comprises a combination of zinc oxide, aluminum oxide and aluminum powder. The preparation raw materials of the heat-conducting silicone grease provided by the invention comprise the combination of the organic silicone oil, the silane coupling agent, the powder treating agent and the heat-conducting powder, and through screening and synergistic compounding of specific components, especially introduction of the specific silane coupling agent, the powder treating agent and the specific heat-conducting powder, the prepared heat-conducting silicone grease has the advantages of ultra-low heat resistance, high heat conductivity, high heat resistance, high heat resistance and the like. And the yield stress matched with the thermal resistance is realized, so that the heat dissipation capability and the operability are relatively good.

The invention relates to a water jet-laser / mechanical energy field cooperative precision machining method for a ceramic base material, and belongs to the field of laser-mechanical cooperative machining. During the execution period, the method comprises the following steps in sequence: firstly, carrying out rapid and low-damage precise material reduction on the ceramic matrix composite material through water jet assisted laser; and then, a superhard forming grinding wheel on the same machine tool is matched with mixed grinding fluid to conduct in-situ finishing and polishing on the surface obtained after material reduction. Wherein the surface quality can be improved while high-efficiency machining is ensured through the synergistic combination of laser and machinery. Through the in-situ grinding and polishing effect of the grinding wheel and the mixed grinding fluid, the precision of a formed surface is higher, and a damaged layer is thinner and even completely removed. Based on a water jet assisted laser milling / mechanical grinding and polishing collaborative machining strategy, rough machining, finish machining and fine polishing of the ceramic matrix composite can be completed on the same equipment, and the method has the characteristics of being high in precision, high in efficiency, high in quality and extremely low in surface damage.

The invention relates to Nb / Ti / RE composite microalloyed 20CrMoH steel and a preparation method thereof, and relates to the technical field of steel for high-end robot gears. The Nb / Ti / RE composite microalloyed 20CrMoH steel comprises the following chemical components in percentage by mass: 0.15 to 0.25 percent of C, 0.2 to 0.25 percent of Si, 0.80 to 1.0 percent of Mn, 0.8 to 1.0 percent of Cr, 0.15 to 0.25 percent of Mo, 0.015 to 0.025 percent of Nb, 0.015 to 0.025 percent of Ti, 0.020 to 0.040 percent of Al, 0.0030 to 0.0050 percent of RE, less than or equal to 0.008 percent of P, less than or equal to 0.008 percent of S and the balance of Fe. And the balance of Fe and other inevitable impurities. On the basis of rare earth Y element and Nb / Ti / RE composite microalloying cooperation, a multi-stage rolling process design is combined, a banded structure appearing in traditional CrMo series gear steel hot rolling is eliminated, the structure distribution uniformity is improved, and the mechanical property stability is improved. The gear steel produced through the method is uniform in structure and stable in performance, the performance requirement of high-end gear steel can be met, and remarkable economic benefits are generated.

The invention discloses a natural component composition for conditioning skin micro-ecology, a preparation method of the natural component composition and application of the natural component composition in skin care products for children. The composition comprises a synergistic combination of a sphingomonas fermentation product extract, a haematococcus pluvialis extract rich in astaxanthin, an abelmoschus esculentus fruit extract rich in polysaccharides, and a yeast / zinc fermentation product. The present invention provides improvements in astaxanthin in terms of chemical stability and transdermal permeability. The composition aims to enhance the immature skin barrier, provide a good effect, and support the healthy development of skin microecology, thereby solving the unique physiological needs of children's skin. The invention also describes a preparation method of the composition and application of the composition in cosmetics for children and dermatological products.

Synergistic drug combinations with small molecule PAC‑1 for the treatment of uveal melanoma or cutaneous melanoma. There are currently no targeted drug therapies for mutations associated with uveal melanoma. As no standard therapy or treatment has improved overall survival, up to 50% of patients eventually develop metastatic disease despite basic radiation or surgical treatment. Drug combinations with PAC 1 allow for the use of lower doses of the compound, resulting in cancer cell death in uveal melanoma. Drug combinations with PAC‑1 and the kinase inhibitor entrectinib have shown synergistic effects against uveal melanoma cell lines. Specifically, PAC‑1 and entrectinib have synergistic effects against wild-type and mutant uveal melanoma cell lines (e.g., GNAQ and GNA11).

The present invention relates to a fluoxazole amide composition that provides synergistic control of insect pests and mites under one-time application, and a method for preparing the same. More specifically, the present invention relates to a synergistic composition having a fluoxazole amide or an agrochemically acceptable salt thereof, at least one or more compounds selected from insecticides, at least one or more compounds selected from plant health additives, and a process for preparing said composition, and an agrochemically acceptable excipient. The invention also relates to a pesticidal composition which improves the health, yield, vigor, quality and tolerance to abiotic or biological stress of treated plants, prevents lodging of susceptible plants due to biological and abiotic factors such as heavy rain, wind, insects and disease damage, and also improves the yield, vigor, quality and tolerance to abiotic or biological stress. And provides residue control (i.e., longer duration control) and direct crop protection as well as effective control of insects and mites that are difficult to kill and have drug resistance.

The present invention relates to a dispersant for graphite and graphene and its application. The composition is a synergistic combination of alkyl sulfosuccinate and polyalkylene glycol. Appropriate adding amount thereof can quickly and easily disperse graphite and graphene in the medium, improve its dispersion uniformity and stability, delay its sedimentation, and inhibit its re-accumulation. Furthermore, the present invention can apply graphite and graphene to other media besides non-water-based or organic solvents. The composition of the present invention does not contain flammable volatile chemicals, any fluorine-, silicon- or phosphorus-based compounds, or any aromatic substances. The present invention can not only reduce environmental pollution but also improve the operational safety of relevant personnel.

The invention belongs to the technical field of coatings, and discloses a preparation method and application of a low-temperature fast-curing coiled material powder coating, and the preparation method comprises the following steps: S1, adding raw materials of the low-temperature fast-curing coiled material powder coating into a high-speed mixer, and mixing for 5-8 minutes at the rotating speed of 1200-1600r / min to ensure that the components are uniformly dispersed; s2, adding the mixture into a double-screw extruder for melt extrusion, wherein the temperature of the double-screw extruder is 80-90 DEG C in a first area, 100-110 DEG C in a second area, 120-130 DEG C in a third area and 110-120 DEG C in a fourth area, and the rotating speed is 200-250 r / min; s3, tabletting and cooling to 40 DEG C or below, after coarse crushing, adopting an ACM pulverizer and a grading screen of 80-120 meshes to obtain the low-temperature fast-curing coiled material powder coating, low-temperature curing and fast film forming are achieved through component cooperation, the process adaptability is high, meanwhile, functional filler modified sericite and modified nanometer aluminum oxide are added, and the low-temperature fast-curing coiled material powder coating is prepared. The two synergistically enhance the corrosion resistance, mechanical strength and environmental adaptability of the powder coating paint film.

The invention discloses a silicon wafer surface carbon dirt and EVA treatment method in waste solar photovoltaic silicon wafer recovery, which comprises the following steps: (1) placing a waste solar photovoltaic panel assembly subjected to high-temperature heat treatment in deionized water, and carrying out normal-temperature ultrasonic cleaning and drying; (2) then putting into an organic solvent, and carrying out ultrasonic treatment; (3) putting the silicon wafer obtained after ultrasonic treatment into deionized water, cleaning and recycling; the organic solvent in the step (2) is composed of polyether amine or dimethylformamide and butyl p-hydroxybenzoate or ethylene glycol monoethyl ether acetate. According to the method, the polar solvent and the permeable organic solvent are synergistically combined, EVA residues are efficiently dissolved under the action of ultrasonic waves, and stripping of carbon on the surface is promoted.

The invention relates to the technical field of biological medicines and ophthalmic medicines, in particular to a herbal exosome composition for eye care and treatment and a preparation method thereof. The composition comprises a synergistic combination of herbal exosomes and mesenchymal stem cell exosomes, and further comprises a nano slow-release carrier system. Wherein the herbal exosome is extracted from a traditional herbal plant liquorice by combining gradient centrifugation with a molecular exclusion chromatography method, and herbal active ingredients, namely astragaloside and quercetin, are loaded in the exosome by adopting an electroporation method, so that the pharmacological activity of the exosome is enhanced. The nano slow-release carrier system is of a two-phase slow-release structure; an inner phase is a phospholipid complex loaded with herbal exosomes and mesenchymal stem cell exosomes, and an outer phase is temperature-sensitive hydrogel; the compound is in a liquid state at room temperature, and is rapidly converted into a gel state after being dropped into the ocular surface, so that the retention time of the medicine on the ocular surface is remarkably prolonged, the bioavailability is improved, and the targeting slow release capability aiming at ocular surface tissues is endowed to the compound.

The invention relates to the technical field of cable sheath preparation, and discloses a cable sheath which comprises the following components in parts by weight: basic rubber materials: vinyl-terminated methyl vinyl silicone rubber and crosslinked polyethylene; the synergistic flame-retardant system is prepared from zinc borate, ammonium polyphosphate, melamine, pentaerythritol and composite modified nano montmorillonite; the nano composite additive is prepared from nano silicon dioxide, nano zinc oxide, nano boron nitride and graphene; an interface compatilizer: maleic anhydride grafted polyethylene; according to the invention, through component optimization and synergistic cooperation, on the premise of not depending on a halogen flame retardant, high flame retardance, excellent mechanical properties and stable aging resistance are realized at the same time, and strict requirements of high-end cables on safety and reliability are met. Besides, the material preparation process is simple and controllable, is suitable for large-scale production, and can be widely applied to the fields of high-rise buildings, rail transit, new energy and the like with high requirements on the performance of the cable sheath.

Provided herein are compositions, methods, strategies, kits, and articles of manufacture that are useful, inter alia, in the treatment or prevention of diseases or conditions such as those which may be associated with inflammation, infection, allergy, immune dysfunction, or dysbiosis of the intestinal microbiome. In some aspects, the invention provides a synergistic combination of a prebiotics, e.g., a mixture of human milk oligosaccharides, and a probiotic strain, such as a strain capable of internalizing and consuming the rebiotics, e.g., B. longum subsp. infantis.

The invention belongs to the technical field of cosmetic raw materials, and particularly relates to a plant composition with oil control and acne removal effects and a preparation method and application thereof. The invention provides an oil-controlling and acne-removing plant composition. The oil-controlling and acne-removing plant composition is prepared from a rheum palmatum extract, a scutellaria baicalensis extract, a radix sophorae flavescentis extract, a safflower extract, a campsis grandiflora extract, a chrysanthemum extract, a cockscomb extract and a rose extract in a specific proportion. Through synergistic compatibility of eight plants, the plant composition can effectively inhibit grease synthesis, inflammatory factor expression and propionibacterium acnes growth, so that good oil control and acne removal effects are achieved.

Surfactant blends are disclosed which exhibit improved stability over a wide pH range. The surfactant blends include a polysaccharide-based surfactant and an internal olefin sulfonate surfactant. Methods of making and using the surfactant blends are further provided.

A flame retardant polyamide composition comprising a synergistic combination of an epoxy terminated brominated epoxy polymer and a tribromophenol terminated brominated epoxy polymer. The polyamide composition has excellent heat resistance and good elongation at break properties without the presence of decabromodiphenylethane.

The present invention relates to an oral extract composition comprising Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) extract composition, and its process of preparation. Also relates to the oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient for, improvement, and maintenance of women health more preferably in improving of hot flashes, night sweats, poor sleep, anxiety, sexual dysfunction, mood changes, Genitourinary symptoms in overall improving the quality of life, serum estradiol, progesterone, follicle stimulating hormone (FSH), and cortisol during the period of menopause (perimenopause and menopause). The oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient is used for improving Brain-derived neurotrophic factor (BDNF) levels in women during the period of menopause. The present invention, further related to the extraction process of Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.), also provides the process for the preparation of formulation composition. This invention further relates to the extraction process from Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) either as individual herbs or co-extraction of the two herbs or mixing the extracts at various stages of the individual extracts.

This invention relates to a synergistic composition comprising combination of palmitoylethanolamide, Acetyl carnitine, and uridine, or their pharmaceutically acceptable salts, derivatives, isomers, or deacetylated form thereof for controlling neuromuscular pain and repairing nerve damage. The present invention provides a synergistic composition for the management of nerve health. The invention specifically provides a composition that exhibits a synergistic effect and demonstrates therapeutic effectiveness comparable to standard chemical drug.

The present invention relates to a composition containing (a) a guanidine and / or an unsubstituted guanidine salt, and (b) at least one further component selected from the group consisting of 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, 1, 2-benzisothiazolin-3-one, N-butyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, the cleaning agent is prepared from 2-benzisothiazolin-3-one, octyl isothiazolinone, bronopol, dibromo-nitrilopropionamide, dibromo-dicyanobutane, butyl carbamic acid iodopropynyl ester, aminomethyl propanol, aminoethyl propylene glycol, monoethanolamine, ethylhexylglycerin, hexylglycerin, 1, 2-pentanediol, 1, 2-hexanediol, 1, 2-heptanediol, 1, 2-octylene glycol, phenoxy ethanol and phenethyl alcohol. The cleaning agent is prepared from phenyl propanol, benzyl alcohol, isopropanol, ethylenediamine tetraacetic acid, (1-hydroxyethylidene) diphosphonic acid, 2-mercaptopyridine sodium oxide, 2-mercaptopyridine zinc oxide, o-phenylphenol, sorbic acid, benzoic acid, salicylic acid, lactic acid, citric acid and zinc. The invention also relates to an industrial product containing components (a) and (b), and to the use of said composition for the preservation of containers and for the preservation of industrial products. The invention also relates to the use of (a) a guanidine and / or an unsubstituted guanidine salt for improving the antimicrobial efficacy of one or more compounds selected from the group (b) described above.

Provided are methods for treating a disease or condition associated with reduced autophagy in a patient, which includes administering to the patient, either simultaneously or sequentially, a therapeutically effective amount of a synergistic combination of compounds from at least two and preferably three of the classes of compounds selected from a saccharide, a vitamin, a ketone body, a polyphenol, and a methylxanthine. The compounds may be present in a subtherapeutic effective amount relative to the compound's dosing when given as a single agent. Also provided are pharmaceutically acceptable compositions and kits including at least two and preferably three of the named classes of compounds.

The present invention relates to the field of pesticide technology, and more specifically to a fungicide composition that improves the effectiveness of preventing and treating jackfruit fruit rot. The fungicide composition, comprising a compound of farnesol and cyproconazole as active ingredients; the mass ratio of farnesol to cyproconazole is 1-9:5-1. Based on existing pesticides, the present invention compounds different active ingredients of pesticides to screen for synergistic combinations. This combination can improve the effectiveness of preventing and treating jackfruit fruit rot, reduce pesticide application dosage, and delay the development of drug resistance in pathogens.

An orally administered composition for treating or reducing damage to connective tissue or for treating or reducing inflammatory symptoms associated with damage to connective tissue includes a synergistic combination of (i) avocado / soybean unsaponifiables; and (ii) a lipoic acid or a salt or derivative thereof. A method for treating or reducing damage to connective tissue, for treating or reducing inflammatory symptoms associated with damage to connective tissue, or for reducing the level of one or more inflammatory mediators in connective tissue includes administering the orally administered composition to an avian or mammalian subject.

Methods and compositions promote weight loss in mammals, such as in humans and / or animals, such as, for example, pets. Specifically, the methods and compositions herein promote weight loss due to the production of appetite-suppressing gut hormones, increased metabolism, reduced fat and carbohydrate absorption, and reduced fat deposition through the synergistic combination of fibers and botanical extracts. Food products comprising the compositions herein provide a natural and effective means of controlling appetite and managing weight.