50 results about "Hydroxycinnamic acid" patented technology

The application discloses application of 2-amino isophthalic acid (2-AIA) as a MALDI matrix in characterization of oligosaccharide additives in food. The skeleton structure of 2-AIA has a strong ultraviolet absorption group and a protonation site, which is beneficial to laser energy transmission and desorption ionization process of the measured object. Meanwhile, 2-AIA has multiple polar functional groups, which can effectively enhance the directional combination of the hydroxyl group of 2-AIA and oligosaccharide, and improve the anti-interference ability of impurities in a complex system. In addition, 2-AIA and a traditional organic matrix alpha-cyano-4-hydroxycinnamic acid (CHCA) are combined as a binary matrix (CHCA / 2-AIA), which can play a synergistic role of the double matrix, significantly improve the detection sensitivity of oligosaccharide. On the other hand, the combination of CHCA and 2-AIA with different pH values can significantly improve the uniformity of the co-crystallization, and improve the accuracy and reproducibility of quantitative detection.

To provide a rubber composition to be a raw material of a vulcanized rubber excellent in steering stability and wet grip performance when used as a rubber part of a pneumatic tire, especially a pneumatic tire for motor sports.SOLUTION: A rubber composition comprising 100 parts by mass of a rubber ingredient containing at least a diene rubber, 0.1 to 10 parts by mass of a cinnamic acid compound having a hydroxyl or methoxy group-substituted aromatic ring, and 40 to 140 parts by mass of carbon black having a nitrogen-adsorption specific surface area of 140 to 250m2 / g. The cinnamic acid compound is a naturally occurring compound and is preferably at least one of 3, 4-dihydroxycinnamic acid and 3, 4-dimethoxycinnamic acid.SELECTED DRAWING: None

The invention relates to the technical field of biological medicine, in particular to application of esterified derivatives of methyl p-hydroxycinnamate in preparation of antitumor drugs. Experiments show that the derivative has an obvious inhibition effect on the cell viability of tumor cells such as gastric cancer, nasopharynx cancer and breast cancer, particularly has obvious proliferation, migration and invasion inhibition ability on the gastric cancer cells, can induce apoptosis of the gastric cancer cells, has relatively low toxic and side effects, and provides a new medicine for treating the gastric cancer.

The present invention relates to a composition comprising: 1) at least one inorganic UV filter selected from titanium dioxide; 2) at least one α-cyanodiphenylacrylate derivative of the given formula; and 3) at least one 4-hydroxybenzylidenemalonate or 4-hydroxycinnamate derivative of the given formula. The present invention also relates to a cosmetic method for treating skin against UV radiation using said composition.

The present invention provides a biomass-derived polyester compound useful as a rubber material or an adhesive material, the compound including a multiple bond in the molecule. By synthesizing an ester compound composed of a hydroxycinnamic acid and a fatty acid, and carrying out polycondensation reaction using the ester compound as a monomer, a polyester compound containing cinnamic acid and a ricinoleic acid derivative that are alternately linked to each other can be efficiently obtained. For example, an ester compound of General Formula (1) is produced. (In the formula, the substituents R1 and R2 each represent a hydrogen atom or a methoxy group; the substituent R3 represents an alkyl group or an alkenyl group; and n represents an integer of 10 to 100).

The present application provides a kind of compound composition for preventing and treating plant wilt, the composition composition includes 4-hydroxy cinnamic acid and thymol, mass ratio is 1:1~1:2;The mass ratio of the composition is 1:1, the concentration of the composition is 60~300 μg / mL;The mass ratio of the composition is 1:2, the concentration of the composition is 50~200 μg / mL;The present application can inhibit the growth of pepper fusarium oxysporum f.sp.cubense mycelium, spore germination and sporulation, and can play a synergistic effect.The composition in the present application can significantly reduce the incidence of wilt in pot experiment.Compared with the prior art, the present application aims to reduce the use of chemical pesticides by low-cost, safe and efficient plant-derived antibacterial compounds.

Disclosed herein are recombinant host cells and methods capable of producing tyramine-containing hydroxycinnamic amide compounds, derivatives, and extracts.SOLUTION: Some embodiments provided include, for example, consumable products containing tyramine-containing hydroxycinnamic acid amides produced by recombinant host cells. Some embodiments provided herein are methods for producing tyramine-containing hydroxycinnamic amide or hydroxycinnamic amide derivatives.SELECTED DRAWING: None

This invention generally relates to the use of hydroxycinnamic acid or its derivatives, such as alginate, in cosmetic or therapeutic settings. The invention further relates to compositions comprising hydroxycinnamic acid or its derivatives.

The present invention relates to a method for obtaining an extract of the leaves of Rosmarinus officinalis (rosemary) involving two stages of maceration, filtration, concentration of the two drained products and drying, guaranteeing an extract comprising mainly hydroxycinnamic derivatives, rosmarinic acid, luteolin, neptin and carnosol, and the use of the extract in cosmetic compositions in the prevention and treatment of androgenetic alopecia, in which the extract of the invention acts through multiple mechanisms of action, and can be used in men and women.

The present invention discloses an edible treatment composition comprising non-toxic and non-hazardous chemicals to extend the shelf-life and maintain freshness of mushroom for prolonged time during its storage and shipment. The disclosed edible treatment composition includes Kojic Acid, L-arginine, Hydroxycinnamic acid (HCA) and optionally additional active or inactive components like antimicrobial agent, etc. This invention is concerned with the treatment of mushroom with disclosed edible treatment composition, pre- or post-harvest, to extend its shelf-life by imparting one or more properties like, maintained whiteness, delayed browning, delated pileus (cap) opening, better firmness, maintained structural integrity, slower weight-loss, etc. for prolonged time, amongst others.

The invention provides application of dragon's blood and active ingredients thereof in preparation of a medicine for treating heart failure, and belongs to the technical field of biological medicine. It is found for the first time that the dragon's blood can significantly improve the heart function of a heart failure model animal, reduce the level of a heart failure marker and relieve cardiac hypertrophy, cardiac pulmonary edema, myocarditis infiltration and fibrosis; core active components such as genistein and 3-hydroxycinnamic acid are screened and verified, wherein the genistein can reproduce the overall treatment effect of the dragon's blood. The invention also discloses that the core action mechanism of the composition is to promote macrophage VEGFC secretion, increase heart lymphatic vessel density and promote lymphatic vessel neogenesis, and a brand new natural drug candidate scheme and an intervention strategy are provided for heart failure treatment.

This invention discloses a modified polyester film for automotive windows and its preparation method, relating to the field of polyester film technology. In preparing the modified polyester film for automotive windows, the invention first reacts methyl p-hydroxycinnamate with [chloro(ethoxy)phosphono]benzene to obtain a modified phosphorus-containing cinnamate diester compound; then reacts nano-antimony tin oxide with a silane coupling agent to obtain pre-modified nano-antimony tin oxide; the pre-modified nano-antimony tin oxide is then reacted with thiazopyridine acid, 6-maleimide-1-hexanal, and ethyl isocyanate to obtain modified nano-antimony tin oxide; terephthalic acid, ethylene glycol, the modified phosphorus-containing cinnamate diester compound, dimethyl 2,2'-difuran-5,5'-dicarboxylic acid, and the modified nano-antimony tin oxide are co-condensed to obtain a modified polyester; the modified polyester is then hot-pressed into a film to obtain the modified polyester film for automotive windows. The modified polyester film for automotive windows prepared by this invention has the advantages of flame retardancy, UV shielding, heat insulation, self-healing, and anti-aging properties.

The invention discloses a sunscreen synergistic supramolecule as well as a preparation method and application thereof, and belongs to the technical field of supramolecules. The sunscreen synergistic supramolecule comprises a sunscreen synergistic substance and a ligand, and the sunscreen synergistic substance is connected with the ligand through an intermolecular acting force; the sunscreen synergistic substance is a ferulic acid substance, a 4-hydroxycinnamic acid substance, a baicalin substance, a chlorogenic acid substance or a rutin substance; the ligand is tranexamic acid, nicotinamide, arbutin, tartaric acid or ascorbic acid. The sunscreen synergistic supramolecule provided by the invention has relatively good biocompatibility and mildness, after the sunscreen synergistic supramolecule is added, the stability and the sunscreen effect of the sunscreen agent are remarkably improved, and the biological activity and the effect of the sunscreen agent are improved.

The invention discloses application of 2-hydroxycinnamic acid in treatment of gastric cancer, according to the application, the influence of supernate of lactobacillus salivarius or lactobacillus crispatus on gastric cancer cell apoptosis is detected through a flow technology, and the 2-hydroxycinnamic acid is found to be capable of promoting the gastric cancer cell apoptosis and inhibiting the activity of gastric cancer organs. A metabolite in a supernatant of lactobacillus salivarius CICC23175 or lactobacillus crispatus CGMCC1.2743 screened by non-target metabolite omics contains 2-hydroxycinnamic acid, and the gastric cancer cytotoxic resistance of 2-hydroxycinnamic acid is deeply studied to find that the 2-hydroxycinnamic acid not only has the effects of inhibiting gastric cancer cell proliferation, colony formation and cell migration, but also has the effects of inhibiting gastric cancer cell proliferation, colony formation and cell migration. In addition, the 2-hydroxycinnamic acid can also increase the proportion of cells in a G1 / G0 period of a cell cycle, promote apoptosis of gastric cancer cells, and find that the inhibition effect of the 2-hydroxycinnamic acid on proliferation of gastric cancer organs is integrally higher than that of normal gastric epithelium organs.

The present invention provides a recombinant bacterium and a method for producing p-hydroxycinnamic acid using the recombinant bacterium. Heterologous aldolase and fumarase genes are integrated into the genome of the recombinant bacterium.

This invention relates to a strain of *Pseudomonas proteus* PHBA133 and its applications, belonging to the field of bioengineering. The strain, classified as *Pseudomonas proteus* coglossicida PHBA133, was deposited at the China General Microbiological Culture Collection Center on December 26, 2022, with accession number CGMCC No. 26275. The *Pseudomonas proteus* PHBA133 provided by this invention exhibits strong genetic stability and a broad substrate spectrum. It can ferment and convert p-hydroxycinnamic acid and its derivatives into corresponding aldehydes, with a conversion concentration of p-hydroxybenzaldehyde as high as 3.4 g / L, demonstrating potential for industrial application. The production process is simple, mild, green, and safe, avoiding the problems of long reaction times, high energy consumption, and environmental pollution faced by traditional chemical methods. Furthermore, it produces fewer byproducts, facilitating extraction and separation operations.

The embodiment of the invention provides a cytochrome P450 hydroxylase mutant and application thereof. According to the cytochrome P450 hydroxylase mutant provided by the embodiment of the invention, a P450 enzyme single mutant CYP199A2-F185L from Rhodopseudomonas palustris is taken as a template enzyme, and the amino acid sequence of the P450 enzyme single mutant CYP199A2-F185L is shown as SEQ ID NO.1. The encoding gene of the protein is modified by adopting a site-specific mutagenesis technology, so that the encoding gene is subjected to amino acid mutation of F188W + V298L + M360W; the cytochrome P450 hydroxylase mutant provided by the embodiment of the invention can selectively catalyze hydroxylation of cinnamic acid to generate 2, 3-dihydroxycinnamic acid, has excellent biological catalytic activity and selectivity, is simple, convenient and efficient to operate, is suitable for industrial production, and has a good application prospect.

The application discloses a sugar derivative of hydroxycinnamic acid, a preparation method thereof and application of the sugar derivative in cosmetics. Specifically, the application provides a sugar derivative of hydroxycinnamic acid, which is a compound as shown in formula I. The sugar derivative of hydroxycinnamic acid has better water solubility and stability than original hydroxycinnamic acid, and has one or more functions such as antioxidation, whitening, soothing, moisturizing and ultraviolet absorption. The application of the sugar derivative in cosmetics can reduce photoaging damage of skin and brighten skin color.

The current invention relates to a herbicide enhancer agent for enhancing the efficiency of herbicides, comprising a polymer of a hydroxycinnamic acid with an average molecular mass higher than 400 g / mol. The invention also relates to a herbicidal formulation comprising: a herbicide and a polymer, wherein, the polymer is a polymer of a hydroxycinnamic acid with an average molecular mass higher than 400 g / mol, and the weight ratio of the herbicide to the polymer is between 1:10 and 1000:1. The invention also relates to the use of said formulation. The invention furthermore relates to a method for controlling weeds or for aiding harvest (desiccant).

The invention provides an antibacterial anti-mite down fiber, a preparation method thereof and a down product. The preparation method of the antibacterial and anti-mite down fiber comprises the following steps: S1, adding 3, 4-dihydroxy ethyl cinnamate and fatty alcohol-polyoxyethylene ether into water to obtain a water phase; dibenzoyl peroxide and tea tree essential oil are added into ethyl alcohol, and an oil phase is obtained; mixing the water phase and the oil phase, homogenizing, and stirring and reacting in a water bath in a protective gas atmosphere to obtain a reaction solution; performing spray drying on the reaction liquid to prepare microcapsules; s2, adding microcapsules into water, and stirring to obtain modified liquid; s3, placing the down fibers in the modification liquid for reaction, washing and drying. According to the application, dibenzoyl peroxide is heated and decomposed to generate free radicals, self-polymerization reaction of 3, 4-dihydroxy ethyl cinnamate is initiated to form a polymer, the polymer can coat the tea tree essential oil with antibacterial and anti-mite effects, phenolic hydroxyl groups contained in the polymer are combined with proteins in the down fibers through the effects of hydrophobic bonds and the like, and the antibacterial and anti-mite effects of the down fibers are improved. The down fibers are endowed with antibacterial and anti-mite effects.

The application discloses a HPLC fingerprint spectrum establishing and content determination method of Zha Dihu, and belongs to the technical field of drug chemical component analysis. The application establishes a HPLC fingerprint spectrum, confirms that six common peaks in test sample solutions of 14 batches are p-hydroxybenzoic acid, vanillic acid, p-hydroxybenzaldehyde, shatavari glycoside, paeoniflorin and p-hydroxycinnamic acid, adopts SPSS 27 and SIMCA14.1 analysis software, carries out cluster analysis, principal component analysis and orthogonal partial least square discriminant analysis on peak areas of the six identified common peaks in the fingerprint spectrum of the Zha Dihu medicinal materials of the 14 batches, and carries out main component content determination. The chemical component composition of the Zha Dihu is determined, the characteristic components are revealed, and the main components are quantitatively analyzed, so as to provide a scientific basis for quality evaluation, efficacy research and subsequent development and utilization of the Zha Dihu.

The invention discloses an anti-wrinkle anti-ultraviolet core bast fiber spinning yarn and a preparation method thereof, and relates to the technical field of spinning yarns. When the anti-wrinkle and anti-ultraviolet core bast fiber spinning yarn is prepared, 6-bromine-1-hexyl acrylate and N-methylimidazole react to prepare an alkenyl imidazolium salt monomer; the preparation method comprises the following steps: carrying out a reaction on methyl p-hydroxycinnamate and acryloyl chloride to prepare an alkenyl cinnamate monomer; grafting an alkenyl imidazolium salt monomer and an alkenyl cinnamate monomer onto the pretreated flax fiber to prepare a modified flax fiber; performing blowing, cotton carding, drawing and roving processes on the modified flax fibers to obtain flax roving; converging and twisting the rough flax yarn and the polyester filament yarn to obtain core flax yarn; and finishing the core hemp yarn with 1, 6-hexamethylenediamine and coumarin-7-carboxylic acid in sequence to obtain the anti-wrinkle and anti-ultraviolet core hemp spun yarn. The anti-wrinkle and anti-ultraviolet core bast fiber spinning yarn prepared by the invention has the advantages of ultraviolet prevention and bacteria resistance.

The invention provides application of p-hydroxycinnamic acid in preparation of a medicine for preventing and treating noise-induced deafness. The invention has the advantages that the p-hydroxycinnamic acid has the advantages of strong pertinence, high safety, convenience in medication, good patient compliance and the like, not only effectively overcomes the defects of the existing noise-induced hearing loss treatment medicines, but also provides a brand-new preventive treatment thought; important clinical popularization significance and industrial application prospects are realized.

The application provides a fluorescent probe based on a cinnamic acid derivative as well as a synthesis method and application thereof, and relates to the technical field of synthesis of specific probes. The fluorescent probe is prepared by introducing benzyl bromide into the hydroxyl group of a modified structure compound FHA using p-hydroxycinnamic acid as raw material, and a novel bifunctional fluorescent probe capable of specifically detecting Al 3＋ and N2H4 is developed. The application overcomes the defects of the prior art, the probe can specifically detect Al 3+ and N2H4, and has the characteristics of low detection limit, short response time, wide pH application range and the like; the probe has the characteristics of good biocompatibility, small toxicity, good optical properties and the like, and can be applied to cell imaging experiments.

The invention discloses a preparation method and application of a high-efficiency bio-based phosphorus-containing flame retardant and flame-retardant epoxy resin, and belongs to the field of flame retardants, the preparation method of the phosphorus-containing flame retardant comprises the following steps: under an alkaline condition and in an organic solvent, carrying out nucleophilic substitution reaction on p-hydroxycinnamic acid and phenylphosphoryl dichloride, and after the reaction is finished, carrying out acidification and purification treatment to obtain the phosphorus-containing flame retardant. The phosphorus-containing flame retardant is obtained. The invention has the advantages of low production cost, environmental protection, simple preparation process and low equipment requirement.

The invention discloses lactobacillus gasseri capable of converting anthocyanin to generate various active metabolites and improving oxidative stress relief of the anthocyanin, and belongs to the technical field of microorganisms and the technical field of medicines. The lactobacillus gasseri CCFM1498 provided by the invention can be used for converting anthocyanin to generate a plurality of active substances such as 3, 5-dihydroxybenzoic acid, p-hydroxycinnamic acid, 2, 4, 6-trihydroxybenzaldehyde and the like; a fermentation product obtained after anthocyanin is fermented by the lactobacillus gasseri CCFM1498 has the following effects: (1) the survival rate of oxidative stress cells is increased; (2) the oxidation resistance of cells is improved; (3) the antioxidant enzyme activity of oxidative stress cells is improved; (4) reducing the content of oxidation products of oxidative stress cells; and (5) activating an Nrf2 signal channel. The lactobacillus gasseri CCFM1498 fermented anthocyanin provided by the invention can be used for preparing a product for relieving oxidative stress, and has a huge application prospect.

The invention discloses a mild freckle-removing and whitening essence with light and heat stability and a preparation method of the mild freckle-removing and whitening essence. The essence is prepared from a whitening component, a moisturizing component, an anti-inflammatory component and a light stabilization protective agent, wherein the whitening component is prepared from nicotinamide, tranexamic acid, glabridin, a beixian extract, nonapeptide-1 and 3-o-ethyl ascorbic acid; the moisturizing component comprises acetylchitosamine, betaine, galactose yeast-like bacterium fermentation product filtrate and a hydrolyzed opuntia ficus-indica flower extract; the anti-inflammatory component comprises dipotassium glycyrrhizinate and bisabolol; and the light stabilization protective agent is p-hydroxycinnamic acid. All the components have a synergistic effect according to the specific weight percentage, so that the effects of inhibiting melanogenesis at multiple targets, enhancing the skin barrier and resisting inflammation and relieving are achieved. The preparation method ensures the stability through split-phase mixing. The problems that an existing whitening product is poor in stability, high in irritation, single in effect and the like are solved.

This invention discloses a method for producing UV-protective fabric using biomass fibers, belonging to the field of textile materials technology. First, hydroxypropyl chitosan is modified with epoxy fatty acids and then combined with carboxymethyl cellulose and baicalin to prepare composite bio-based UV microcapsules via a complex coagulation method. Subsequently, these microcapsules are compounded with aqueous polyurethane to form a finishing solution, which is then coated onto Lyocell fibers to obtain microcapsule-loaded Lyocell fibers. Simultaneously, p-hydroxycinnamic acid is grafted onto PET fibers. Finally, WPU is applied and hot-pressed to form the two layers of fibers, resulting in the UV-protective fabric. This invention improves upon the problems of traditional fabrics, such as easy loss of function, easy peeling between layers, and a stiff feel, by constructing a two-layer composite structure of microcapsule-loaded Lyocell fibers and UV-grafted PET fibers. It achieves a balance between protective performance and wearing comfort, and is applicable to functional textiles such as outdoor sun-protective clothing and sunshade mesh.

A nano-drug delivery system modified with a phenolic acid or dipeptide for increasing the oral absorbability and bioavailability, which system is prepared from a nanocarrier and an auxiliary material. The nanocarrier is modified with a phenolic acid or dipeptide on the surface thereof as a ligand, and actively targets a receptor on the surface of intestinal epithelial cells, wherein the phenolic acid ligand is a hydroxycinnamic acid derivative, and the dipeptide ligand is a combination of a cationic amino acid and a neutral amino acid. An oral nano-drug delivery system is constructed by using a phenolic acid or dipeptide, which is an essential nutrient for a human body, as a ligand to mimic the absorption pathway of phenolic acid or dipeptide, which system significantly enhances the oral absorption efficiency of a drug by using the natural highly-efficient absorption capacity of the small intestine for nutrients.

The application discloses a heat-resistant hydroxycinnamic acid decarboxylase derived from abnormal Wickerham sp., and belongs to the technical field of enzyme engineering. The optimal reaction temperature of the hydroxycinnamic acid decarboxylase is 40 DEG C, and the activity is stable in the range of 40 DEG C to 70 DEG C. This provides certain theoretical basis and practical significance for industrialization of high-efficiency preparation of 4-vinyl derivatives and other high-grade perfume materials by using the hydroxycinnamic acid decarboxylase.