240 results about "Oral solutions" patented technology

The invention discloses a CAD detection method for phosphoric acid and phosphorous acid in an alendronate sodium oral solution, and belongs to the technical field of pharmaceutical analysis. The method comprises the following steps: preparing a reference stock solution and a test solution; then setting high performance liquid chromatography detection conditions; a Shodex VN-504D chromatographic column is adopted, a CAD detector is adopted as a detector, a mixed solution of a mobile phase A and a mobile phase B is adopted as a mobile phase, the mobile phase A is ammonium formate, the mobile phase B is an acetonitrile solution, and gradient elution is performed by adopting the mobile phase; and respectively measuring the reference stock solution and the test solution, injecting into a liquid chromatograph, and recording a chromatogram. A CAD detector is adopted, the detection sensitivity is obviously improved, the quantitative concentration can reach 0.24 mu g / mL, and the detection concentration can reach 0.10 mu g / mL. The method is high in specificity, high in sensitivity, good in durability, rapid, simple, effective and reliable.

The invention discloses an ebastine oral solution preparation method, which comprises: 1, weighing 5-20 parts by mass of ebastine, 50-100 parts by mass of a thickening agent, 10-18 parts by mass of a bacteriostatic agent, 1800-2000 parts by mass of a thickening agent, 0.1-0.2 part by mass of a defoaming agent, 600-700 parts by mass of a sweetening agent, adjusting the pH value to 3.5-4.5 by using a pH value adjusting agent, and carrying out a proper amount of water; 2, adjusting the temperature to 35 DEG C, adding ebastine into the thickening agent, and stirring to completely disperse the ebastine; 3, adding part of purified water, an acidity regulator and a thickening agent, and stirring until the materials are completely dissolved; 4, adding the sweetening agent, the bacteriostatic agent and the defoaming agent, and stirring until the materials are completely dissolved; 5, cooling after complete dissolution, and adjusting the pH value to 4 by using an alkaline regulator; step 6, fixing the volume; by optimizing the preparation process, efficient dissolution of the ebastine oral solution is realized, the problems of clinical application pain points of tablets and low solubility of raw material medicines of the oral solution are solved, and a safer and more convenient treatment choice is provided for special crowds.

The invention provides a dexketoprofen trometamol oral solution and a preparation method thereof. According to the dexketoprofen trometamol oral solution, polyethylene glycol 400 and hydroxypropyl methylcellulose are used as stabilizing agents, methylparaben and propyl hydroxybenzoate are used as bacteriostatic agents, sucralose and ammonium glycyrrhizinate are used as sweetening agents, essence is used as a flavoring agent, and the pH value of the solution is controlled to be 6.2-6.8 through a pH value regulator. The increase of the impurity A, the impurity B, the impurity C, the impurity E and the total impurity is obviously reduced, so that the product stability is obviously improved.

Oral pharmaceutical solution comprising a pharmaceutically acceptable salt of lisdexamfetamine, and a pharmaceutically acceptable aqueous carrier comprising a buffer and a cosolvent selected from the group consisting of a glycol, a polyol, and a mixture thereof, wherein the pH of the solution is from 5.5 to 9.0. The oral pharmaceutical solution presents excellent physicochemical stability, even under alkaline conditions.

The invention relates to the technical field of pharmaceutical analysis, in particular to a detection method of a compound sodium picosulfate oral solution, which is used for detecting sodium picosulfate and related substances. The detection method comprises the following steps: carrying out liquid chromatography detection on the compound sodium picosulfate oral solution; the conditions of the liquid chromatography detection are as follows: (1) a chromatographic column is a reverse C18 chromatographic column or an efficiency equivalent column thereof; (2) taking a mixed solution of an ammonium acetate buffer salt solution and methanol as a mobile phase A and acetonitrile as a mobile phase B; wherein the pH value of the ammonium acetate buffer salt solution is 4.9 to 5.2; and (3) gradient elution is adopted. The quality detection method disclosed by the invention can be used for the preparation process of the compound sodium picosulfate oral solution and the quality control of the final product, is good in specificity, good in separation degree, high in sensitivity and good in reproducibility, and has important significance for evaluating the advantages and disadvantages of synthesis and preparation processes, controlling the quality of the final product and detecting a stable sample.

Oral pharmaceutical solution comprising a pharmaceutically acceptable salt of lisdexamfetamine, and a pharmaceutically acceptable aqueous carrier comprising a buffer and a cosolvent selected from the group consisting of a glycol, a polyol, and a mixture thereof, wherein the pH of the solution is from 5.5 to 9.0. The oral pharmaceutical solution presents excellent physicochemical stability, even under alkaline conditions.

Disclosed herein is a ready-to-use, non-aqueous oral solution of losartan. Also disclosed herein is a method of preparing a ready-to-use, non-aqueous oral solution of losartan and its method of use.

The invention relates to a method for determining the content of sorbitol and glycerol as auxiliary materials in a fudosteine oral solution, which has the advantages of high sensitivity, strong specificity, good accuracy and simple and rapid operation, can reduce the difficulty of preparation development, reduce the workload of prescription development, shorten the research and development time and further improve the BE passing rate, and has practical significance.

The application belongs to the technical field of drug dissolution and dispersion, and particularly relates to a bunazosin water-based solution preparation and a preparation method. The bunazosin water-based solution preparation provided by the application comprises the following components: bunazosin, gamma-cyclodextrin, lecithin, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, aspartame and water. The above components are mixed to be homogeneous to prepare an oral solution which is uniform, clear and can be stored for a long time. The scheme of the application further enriches the dosage form of bunazosin, improves the convenience of taking bunazosin, and is expected to help improve the oral bioavailability and absorption efficiency of bunazosin. The scheme of the application also provides a reference direction for the mechanism research on the dissolution and dispersion behavior of the insoluble bunazosin macromolecule in a water medium.

The present application provides a detection method and quality control method for related substances in dextromethorphan oral solution, which comprises the following steps: dissolving dextromethorphan oral solution in a solvent to obtain a test solution; and performing high performance liquid chromatography detection on the test solution; the mobile phase used in the high performance liquid chromatography detection comprises mobile phase A and mobile phase B, the mobile phase A comprises a phosphate solution, the mobile phase B comprises acetonitrile, and the concentration of the phosphate solution is 0.1 mM-10 mM. The detection method has good linear relationship between dextromethorphan and related substances, good accuracy and sensitivity, strong specificity, high stability, good separation degree and good reproducibility, and is suitable for wide application.

The invention relates to the technical field of medicines, in particular to a briracetam oral solution and a preparation method thereof. According to the present invention, by adjusting the formula and the preparation process of the oral solution of the briracetam, the stability of the briracetam is effectively improved, the antibacterial effect is effectively improved without adding the preservative, the taste of the oral solution is adjusted, and the medication compatibility of children patients is improved.

1. Name of the designed product: packing box (milk fruit sugar oral solution). 2. Use of the designed product: for product packing. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo showing the design points: perspective view 1.

The utility model discloses atomoxetine hydrochloride oral solution filling equipment, which belongs to the field of oral solution filling, and comprises a support frame and a push plate, a conveying mechanism is arranged above the support frame, two limiting plates are symmetrically arranged on two sides of the top of the support frame, the two limiting plates are arranged on two sides of the conveying mechanism, and the push plate is arranged on the support frame. Empty bottles are evenly placed on the surface of the conveying mechanism, the empty bottles are placed between the two limiting plates, fixing frames are symmetrically arranged on the surfaces of the two sides of the supporting frame, the fixing frames are vertically arranged, a top plate is fixed to the tops of the four fixing frames, and the top plate is arranged above the conveying mechanism in a suspended mode. And air cylinders are symmetrically and vertically arranged on the two sides of the top of the top plate, push plates capable of getting close to or getting away from each other are arranged on the two sides above the conveying mechanism, and the push plates on the two sides can be moved to get close during filling, so that empty bottles are extruded through positioning V-shaped grooves in the surfaces, then the empty bottles are calibrated, the accuracy during filling is guaranteed, and liquid leakage is prevented.

The invention discloses a data security traceability system and method in an oral solution medicine production process, and belongs to the technical field of medicine data security traceability. The system comprises a data traceability module which constructs an information data traceability chain based on each group of factory oral solution drugs; the source data calling module is used for calling the information data traceability chain of the oral solution medicine with the query information and marking source data; the risk analysis module is used for determining risk data of the oral solution medicine on the basis of a plurality of pieces of source data and the number of the marked query information corresponding to each piece of source data; the medicine distribution area management module is used for determining the number of oral solution medicines with risk data in each area based on the transportation data of the medicine distribution area; and the safety early warning module is used for judging whether a disease spreading risk exists or not based on the sales data of the medicine distribution area. According to the invention, abnormal data in the drug production and circulation process can be accurately locked through the traceability system, and the transparency of drug information is improved.

The present invention relates to the field of pharmaceutical technology, and more particularly to a compound sodium picosulfate oral solution and a preparation method thereof. The oral solution comprises the following components: sodium picosulfate, anhydrous citric acid, magnesium oxide, a stabilizer, an antibacterial agent, and a pH adjuster, wherein the antibacterial agent comprises methylparaben and propylparaben in a mass ratio of 15:1-6:1. The present invention has the advantages of high stability and good antibacterial efficacy.

The present application relates to the field of pharmaceutical analysis, and particularly relates to a method for determining the content of cetirizine hydrochloride and preservatives in cetirizine hydrochloride oral solution. The method provided by the present application uses octadecyl bonded silica as the filler of the chromatographic column, uses a mixed solution with specific composition and proportion as the mobile phase, adopts isocratic elution, uses a content volumetric pipette to prepare the test sample solution, injects the test sample solution and the mixed control solution into the liquid chromatograph respectively to perform liquid chromatography, thereby obtaining the chromatogram of the test sample solution and the chromatogram of the mixed control solution respectively; and then according to the external standard method, the content of cetirizine hydrochloride, the content of the hydroxy methylbenzoate preservative and the content of the hydroxy propylbenzoate preservative in the cetirizine hydrochloride oral solution are calculated by the peak area. The method has strong specificity, high accuracy, good precision, linear relationship and stability, and is conducive to the evaluation of sample quality.

1. Name of the designed product: medicine packing box (vitamin D oral solution). 2. Use of the designed product: packing for vitamin D oral solution. 3. Design points of the designed product: in the pattern. 4. Picture or photo best indicating the design points: perspective view.

Liquid formulation including cevimeline hydrochloride and a combination of at least one sweetener and at least one flavoring agent to mask the bitter taste of cevimeline hydrochloride oral solutions. The liquid formulation may be administered to a patient to alleviate dry mouth symptoms associated with xerostomia and Sjogren's syndrome.

The utility model discloses a kind of oral liquid bottle caps with quantitative drop hole, comprising: inner plug, insert in oral liquid bottle mouth;And outer cover, cover on oral liquid bottle mouth, and cover inner plug in it;The inner plug includes plug body;Dripping channel is provided in the middle part of the plug body, and dripping port is provided at the top of the plug body, and liquid inlet is provided at the bottom of the plug body, dripping port and dripping channel intercommunicate, and dripping channel and liquid inlet intercommunicate;Extension body structure is provided at the side of the plug body, airflow passage I that passes through up and down is provided in the extension body structure, airflow passage II that passes through up and down is provided in plug body, and airflow passage I is communicated with airflow passage II.The utility model does not need external suction tube or dropper, with quantitative dripping function, solve most oral solution in the course of taking cannot control medicine liquid drop speed and drop weight, cannot realize the problem of accurate quantitative dosing.

The invention relates to the technical field of pharmaceutical analysis, in particular to a method for determining the content of a sodium picosulfate oral solution. According to the method, high performance liquid chromatography is adopted for detection, a chromatographic column with octadecylsilane chemically bonded silica as a filler is selected, a phosphate buffer solution (10.9 g of monopotassium phosphate is taken, 1000ml of water is added to dissolve the monopotassium phosphate, and the pH value is adjusted to 3.5 with phosphoric acid) is taken as a mobile phase A, methanol is taken as a mobile phase B, and gradient elution is carried out. By adopting the method, the content of the sodium picosulfate oral solution can be effectively detected, the method has the advantages of strong specificity, good reproducibility, simplicity and convenience in operation and the like, and the quality of the sodium picosulfate oral solution can be effectively guaranteed.

The present invention relates to a novel oral solution of a bitter drug using vitamin E TPGS as a masking agent. Atoxetine HCl is an example of a bitter drug, the bitter taste of which can be masked by the presence of vitamin E TPGS.

The invention relates to the technical field of packaging equipment, and provides bottle opening leakage-free packaging equipment for oral solution production, which comprises a mounting case, medicine bottle conveying racks are arranged on two sides of the top of the mounting case, medicine bottle packaging equipment is arranged on one side of the top of the mounting case, and the bottle opening leakage-free packaging equipment further comprises an overturning rack and a filling pipe, the overturning rack is rotationally arranged in the middle of the top end of the mounting case through a rotating shaft seat, the overturning rack overturns along the central point of the rotating shaft seat, the medicine bottle conveying rack and the overturning rack are each provided with a medicine bottle conveying structure, the number of the filling pipes is multiple, and the multiple filling pipes are longitudinally and movably arranged on the upper side of the overturning rack. By means of the technical scheme, the technical problem that in the prior art, when filling and packaging equipment is used for filling a filling medicine bottle with a solution medicine, due to the leakage problem of a filling pipe, the solution medicine is likely to leak to the top end or the outer side area of the filling medicine bottle, and follow-up packaging of the filling medicine bottle is affected is solved.

1. The name of the design product: packaging box (atomoxetine hydrochloride oral solution). 2. The use of the design product: the design is used for packaging atomoxetine hydrochloride oral solution. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective view.

1. Name of the product in this design: Packaging Box (Danfang Sodium Phosphate Oral Solution). 2. Purpose of this design: For product packaging. 3. The key design features of this product are the combination of pattern and color. 4. The image or photograph that best illustrates the design's key points: a 3D model. 5. The design for which protection is sought includes color.

This utility model discloses a mixing tank for producing lactulose oral solution. Its structure includes a main body, an upper conveying cylinder, and a lower conveying cylinder. Raw materials are conveyed through the inlet to the upper conveying cylinders on both sides, causing the materials inside to move simultaneously towards the central connection port. The materials on both sides push against each other, resulting in the first stage of fusion. Then, under the influence of a lower spiral auger inside the lower conveying cylinder, the materials separate and move to both sides, thus performing a second stage of mixing. Subsequently, the materials are fed into the lower end of the main body through the discharge port. A third motor drives a rotating shaft, causing a stirring rod to agitate the materials again, resulting in further mixing. Then, at the lowest point, a fourth motor drives a rotating shaft, causing the stirring rod to rotate, thus mixing the materials again, resulting in higher mixing efficiency and better mixing effect.

The invention relates to high-content milk mineral salt oral liquid and a preparation method thereof, and belongs to the technical field of food. According to the oral liquid disclosed by the invention, the milk mineral salt is used as a main functional component, and the technical problems of low content and poor stability of the milk mineral salt in an oral liquid system are solved by optimizing a formula and a process. The particle size of the milk mineral salt is controlled to be 6-10 microns, a composite stable system of the milk mineral salt, the calcium promoting absorbent and the thickening agent is formed through process control, the content of the milk mineral salt is high, the stability is high, and the slightly acidic pH value also provides convenience for taste adjustment. According to the product, multiple substances cooperate to promote calcium absorption, high-temperature damage can be resisted, the long-term stability is high, the calcium supplement requirement of all people is met, and the important market application value is achieved.

This invention provides a sample pretreatment method and identification method for identifying ginseng polysaccharides in compound fluorouracil oral solution, belonging to the field of pharmaceutical detection and analysis technology. The sample pretreatment method of this invention includes: centrifuging the compound fluorouracil oral solution and taking the clear solution; adding silica gel to the clear solution, mixing, and removing the solvent to obtain a solid mixture; adding ethanol solution or anhydrous ethanol to the obtained solid mixture, heating and refluxing, discarding the ethanol solution, and obtaining the residue; adding water to the obtained residue, sequentially extracting and centrifuging, taking the supernatant obtained by centrifugation, removing the solvent from the supernatant, and then redissolving it with water; the identification method of this invention is thin-layer chromatography analysis, and the developing solvent includes the following components in parts by volume: 6.8-9.2 parts of n-propanol, 1.76-2.24 parts of water, 0.75-1.24 parts of ethyl acetate, and 0.75-1.24 parts of glacial acetic acid. The sample pretreatment method and identification method for identifying ginseng polysaccharides in compound fluorouracil oral solution of this invention have high specificity.

The utility model discloses a stock solution filtering device for preparing a calcium zinc gluconate oral solution, which comprises a stock solution storage tank and a filtering tank, the outer surface of the stock solution storage tank is fixedly communicated with an eduction pipe, the outer surface of the filtering tank is fixedly communicated with an ingress pipe, and a multi-layer processing mechanism is arranged between the eduction pipe and the ingress pipe. The multi-layer treatment mechanism is used for carrying out pre-filtration treatment on the stock solution and extracting impurities or particles in the stock solution after pre-filtration, and relates to the technical field of stock solution filtration for preparing the calcium and zinc gluconate oral solution. Furthermore, the collecting box with impurities is extracted from the interior of the treatment box, and the collecting box without impurities is put into the treatment box, so that the conveying of the stock solution does not need to be stopped when the collecting boxes are replaced, and the filtering efficiency of the stock solution is ensured.

This invention provides an birepiperazole oral solution, wherein the solution comprises birepiperazole 0.4-0.6 mg / ml, disodium edetate 0.1-0.5 mg / ml, methylparaben 1.5-2.0 mg / ml, propylparaben 0.15-0.25 mg / ml, an acidic pH adjuster 2.5-3.5 mg / ml, a flavoring agent 0.8-1.2 mg / ml, propylene glycol 40-60 mg / ml, glycerin 120-180 mg / ml, and a sodium hydroxide solution to adjust the pH to 2.9-3.3. The drug exhibits high stability during preparation, storage, and clinical formulation.