1378 results about "Oral solutions" patented technology

The invention relates to a Chinese medicinal preparation for treating bone fracture, which is prepared from 84 raw medicinal materials such as radix astragali, Chinese angelica, rehmanniae vaporata, rehmanniae praeparatum, suberect spatholobus stem, human placenta and the like. The medicament can be made into an oral preparation and external application preparation. A preparation method comprises the following steps: preparing an aqueous extract of the raw medicinal materials, and preparing an oral solution and a spraying agent from the aqueous extract; and preparing extracting pulvis from the aqueous extract, and preparing granules, pills, medicinal granules, tablets or capsules from the extracting pulvis. Raw medicinal powder also can be ground into raw powder pulvis which can be prepared into the granules, the pills, the medicinal granules, the tablets or the capsules, or the raw powder pulvis is prepared into external application ointment. In addition, the raw medicinal materials also can be infused to form medicinal liquor. The Chinese medicinal preparation has good curative effect on bone fracture diseases of different types, is mainly used for treating different types of fracture, muscles and bones breakage, traumatic injury, new and old incised wound and gunshot wound, bleeding and blood stasis which are caused by traumatism and other symptoms, and has the obvious curative effect on rheumatoid arthritis. The Chinese medicinal preparation is prepared from pure Chinese medicaments, and has convenient use, safety, reliability, no toxic or side effect and long-term use.

The invention relates to a Chinese medicinal preparation for treating cancer, and the Chinese medicinal preparation is prepared from 110 raw material drugs, such as yew, barbed skullcap herb, hairyvein agrimony and laggera pterodonta. The preparation can be oral solution, granules, powder, capsules, electuary and tablets. 110 Chinese medicaments are adopted, and monarch, minister, assistant and guide drugs are reasonably compatible and are comprehensively taken to play the effect of treating both principal and secondary aspect of cancers. The raw material drugs adopted in the Chinese medicinal preparation are common Chinese medicaments, and are low in manufacture cost and small in side effect. The medicament has the advantages of capabilities of effectively strengthening the body immunity and attacking pathogen without hurting a body along with quick response, high curative rate, high heal rate, low relapse rate, treatment of both principal and secondary aspect of cancers, safety and reliability, and can be used for treating various types of cancers, especially lung cancer, gastric cancer, liver cancer, esophagus cancer, pancreatic cancer, cervical cancer and breast cancer.

The invention discloses a traditional Chinese medicine preparation for treating cancer, which is prepared by 103 types of bulk drugs such as solidago decurrens, Chinese sage herb, hypericum japonicumand the like. A preparation method of the traditional Chinese medicine preparation comprises the following steps: preparing the bulk drugs into water extract by a conventional method; using the prepared water extract for preparing oral solution by a traditional method; drying the obtained water extraction, then conducting grinding and sieving; taking the throughs for extracting powder, and using the extracted powder for preparing tablets, granules, electuaries or capsules by a traditional method. The preparation method also can be as follows: sieving out the dust of the bulk drugs, conductinggrinding and sieving, taking the throughs, conducting disinfection and sterilization to obtain raw powder, and using the raw powder for preparing tablets, granules, electuaries or capsules by a traditional method. With drugs mixed rationally, the traditional Chinese medicine preparation addresses both the symptoms and root causes of cancer. The bulk drugs are frequently-used common Chinese drugs,have low preparation cost and small side effect, and can effectively enhance own immunity, attack pathogen while do not damage body. The traditional Chinese medicine preparation can cure various typesof cancer, particularly lung cancer, stomach cancer, liver cancer, esophageal cancer, pancreatic cancer, cervical cancer and breast cancer.

A method of treating gastric acid disorders by administering to a patient a pharmaceutical composition comprising a proton pump inhibitor (PPI) in a pharmaceutically acceptable carrier. The present invention provides an oral solution / suspension comprising a proton pump inhibitor and at least one buffering agent. The PPI can be any substituted benzimidazole compound having H+,K+-ATPase inhibiting activity and being unstable to acid. Omeprazole and lansoprazole are the preferred PPIs for use in oral suspensions in concentrations of at least greater than 1.2 mg / ml and 0.3 mg, respectively. The liquid oral compositions can be further comprised of parietal cell activators, anti-foaming agents and / or flavoring agents. The inventive compositions can alternatively be formulated as a powder, tablet, suspension tablet, chewable tablet, capsule, effervescent powder, effervescent tablet, pellets and granules. Such dosage forms are advantageously devoid of any enteric coating or delayed or sustained-release delivery mechanisms, and comprise a PPI and at least one buffering agent to protect the PPI against acid degradation. Similar to the liquid dosage form, the dry forms can further include anti-foaming agents, parietal cell activators and flavoring agents. Kits utilizing the inventive dry dosage forms are also disclosed herein to provide for the easy preparation of a liquid composition from the dry forms. In accordance with the present invention, there is further provided a method of treating gastric acid disorders by administering to a patient a pharmaceutical composition comprising a proton pump inhibitor in a pharmaceutically acceptable carrier and at least one buffering agent wherein the administering step comprises providing a patient with a single dose of the composition without requiring further administering of the buffering agent. Additionally, the present invention relates to a method for enhancing the pharmacological activity of an intravenously administered proton pump inhibitor in which at least one parietal cell activator is orally administered to the patient before, during or after the intravenous administration of the proton pump inhibitor.

An oral solution dispenser apparatus for attachment to a powered toothbrush handle having a drive coupling mounted thereon, includes a housing adapted for attachment to the handle, the housing having a recess therein for receiving a cartridge containing the oral solution, a pump disposed in the housing for moving the oral solution from the cartridge, and an outlet nozzle extending from the housing and adapted to permit movement of the oral solution from the pump and from the housing. A head having bristles thereon is adapted to interconnect with the handle drive coupling and the housing outlet nozzle, to facilitate powered movement of the bristles and movement of the oral solution from the outlet nozzle to proximate the bristles.

Chlorogenic acid, i.e. 1, 3, 4, 5-tetrahydroxycyclohexanecarboxylic acid-(3, 4-dihydroxycinnamic acid ester), exists in a plurality of plants, and also, high purity chlorogenic acid can be prepared through synthesis. Chlorogenic acid has a lot of biological activity, such as antibacterium, antivirus, antioxidation, antitumor and the like. However, there exists no report and research on oral preparations prepared by high purity chlorogenic acid and application of the preparations in clinics. In the invention, high purity chlorogenic acid is extracted from plants or obtained through synthesis, and is then added with a proper amount of accessories, thus obtaining oral preparations like tablets, capsules, granules, oral solutions, etc. The preparations provided in the invention can be applied in clinics for treating cardio-cerebrovascular diseases, infections, hepatitis B, tumors and other diseases, and also can be used in health care medicines for heat clearing and detoxifying, face nursing and skin moistening, as well as hangover relieving, etc.

The present invention relates to stable aqueous oral formulation of bisphosphonic acid or its pharmaceutically acceptable salts. More particularly, the present invention relates to stable aqueous oral formulation of alendronate sodium. The present invention also relates to a process for the preparation of stable aqueous oral formulation of alendronate sodium.

An alcohol-free, oral solution of nizatidine treats gastric and intestinal disorders. Oral doses of solution, which are equivalent to 150 mg twice daily, or 300 mg once daily, pill form of conventional nizatidine are orally administered and have a bioequivalency greater than 70%. The oral solution allows a wider population to obtain nizatidine treatment, particularly children, and the elderly, who have difficulty ingesting pills, can take the oral solution. Also, adolescents and younger children, in particular, can be treated with an alcohol-free oral solution.

Belonging to the food field, the invention relates to a bee pollen cell-wall breaking method, a bee pollen oral solution and its preparation method. Technically, the invention aims to provide a bee pollen cell-wall breaking method and an oral solution prepared with the wall-broken bee pollen. The bee pollen cell-wall breaking method of the invention comprises the step of: adding yeast into the bee pollen for fermentation so as to make the cell-wall of the bee pollen broken. The bee pollen oral solution of the invention is prepared by the wall-broken bee pollen obtained by the above method as an active component together with bromatologically acceptable accessories. The preparation method of the bee pollen oral solution consists of the steps of: breaking bee pollen cell-wall with the above bee pollen cell-wall breaking method, then adding a sweetener of 40-60 wt% of the bee pollen, an acidity regulator of 0.8-1.6 wt% of the bee pollen, as well as water of 4-10 times the weight of the bee pollen, mixing them uniformly, conducting heating and keeping boiling for 5-40min, then carrying out filtration, thus obtaining the filtrate, i.e. the bee pollen oral solution.

The present invention relates to a cannabinoid containing oral solution. Preferably the oral solution comprises a cannabinoid, a lipid solvent, a sweetener and ethanol, characterised in that the sweetener is an ultrahigh potency sweetener.

The invention discloses a composition with the functions of weight losing and waistline reduction and a preparation method of composition. The composition is prepared from the following raw materials in parts by weight: 2-4 parts of hawthorn, 2-6 parts of semen cassiae, 2-6 parts of lotus leaf, 1-3 parts of dried orange peel, 4-15 parts of poria cocos, 3-6 parts of coix seed, 2-6 parts of sealwort, 3-15 parts of astragalus mongholicus, 0.5-2 parts of ginseng, 0.1-1 part of liquorice, 0.5-1 part of white kidney bean extract and 5-10 parts of resistant starch. The composition can be prepared into granules, powder or an oral solution. The composition disclosed by the invention combines traditional Chinese medicines with functions of tonifying spleen, eliminating dampness, reducing fat and losing weight with the white kidney bean extract and the resistant starch which have definite weight-losing function mechanism by combining the mechanism study result of practitioners of Chinese medicines on fat as well as modern science research achievements; and when taking the composition disclosed by the invention, people do not need to diet intentionally, and the composition has no side effects, such as anorexia and diarrhea, achieves the tonic and weight-losing effects, has the advantages of improving the immunity of the organism and ensuring that the waistline and the weight are reduced without rebound and has the favorable efficacies of reducing waistline and losing weight.

The invention discloses an anticancer and antalgic Chinese medicinal Gelsmium elegans total alkaloid and drug combination containing it as well as its preparing method, where the Gelsmium elegans total alkaloid is extracted from the raw material Chinese medicinal Gelsmium elegans and the Gelsmium elegans total alkaloid and acceptable carrier or excipient in any pharmacy are made into drug combination whose drug form can be oral preparation and also injection, concretely speaking tablet, capsule, soft capsule, oral solution, injection solution, transfusion, powder injection and freeze-dried powder injection. The drug combination has good anticancer effect and high-quality ntalgic function and the drug combination's antalgic strength is inferior to morphia's and superior to other clinical antalgics'.

The invention discloses an ambroxol hydrochloride oral solution and a preparation method thereof, and relates to a preparation method of western medicine, in particular to a medical production formula used for curing bronchitis and a preparation method thereof; the preparation method comprises the following steps: sucrose, preservatives and purified water are dissolved in a mixing mode so as to prepare simple syrup; the ambroxol hydrochloride, corrigents and preservatives are dissolved by the purified water so as to prepare ambroxol hydrochloride solution; the ambroxol hydrochloride solution and the simple syrup are stirred and mixed evenly, the corrigents and the preservatives are added successively and discontinuously and then the purified water is added to adjust the concentration. The invention has simple and reasonable process, and is easy to operate practically and the produced products have good stability; the products can used as common phlegm-eliminating drugs, has functions of increasing the liquid level of the respiratory tract, reducing mucus secretion, enhancing the secretion of pulmonary surfactant and the movement of cilium and preventing cough to a certain extent, and is applicable to acute respiratory disease and chronic respiratory disease, such as ropy sputum and difficult cough caused by acute bronchitis and chronic bronchitis, bronchial asthma and pulmonary tuberculosis, etc.

The invention discloses a calcium and zinc gluconate oral solution and a preparation method thereof and is characterized in that 54-66g of calcium gluconate, 1.8-2.2g of zinc gluconate, 9-11g of lysine hydrochloride, 1.8-2.2g of activated carbon, 135-165g of sucrose, 10.8-13.2g of lactic acid, 0.9-1.1g of sodium chloride and 0.45-0.55ml of essence are prepared into 1000ml of the oral solution. The calcium and zinc gluconate oral solution provided by the invention has good taste, is uniform and stable, and is beneficial to the absorption of a human body.

Stable, liquid compositions of levetiracetam that are substantially or entirely free of preservatives, particularly parabens, and / or sugars, such as natural sugars and sugar alcohols. The liquid compositions preferably include oral solutions or suspensions, and may include pharmaceutically acceptable excipients.

The invention relates to a medicinal composition containing strontium salts and vitamin D derivatives. Mixed with auxiliary materials acceptable on pharmacy, the medicinal composition of the invention can be prepared into oral formulations such as particulate granules, common tablets, chewable tablets, dispersible tablets, orally disintegrating tablets, effervescent tablets, buccal tablets, capsules, softgels, sustained release tablets, sustained release capsules, oral solutions, syrups, etc., and can be used to prevent and treat various primary or secondary osteoporosis.

The present invention relates to a dandelion plant phenolic acid effective component for preventing and curing herpes simplex virus infection and its application in preparation of medicine for preventing and curing ulcerative stomatitis. The invented dandelion plant phenolic acid effective component is obtained by using fresh dandelion plant or dried dandelion plant and making it undergo the processes of alcohol and water extraction, column chromatography and alcohol solvent elution, etc. Said effective component can be made into lozenge, powder preparation, spray, granules and oral solution, etc.

The invention discloses a collagen peptide-colla corii asini oral solution and a preparation method thereof. The preparation method comprises the steps of: performing controllable enzymolysis on collagen of a deep sea fish skin which is taken as a raw material, and performing ultra-filtration separation and concentration to obtain a collagen peptide solution with the molecular weight of 500Da-1000Da; stewing and filtering main auxiliary materials of solid colla corii asini, radix polygoni multiflori preparata and radix rehmanniae praeparata to obtain a colla corii asini basic solution, a radix polygoni multiflori preparata solution and a radix rehmanniae praeparata solution; blending the solutions with adlay powder, tea polyphenols, vitamins, a vitamin E, potassium sorbate, honey and water to obtain a mixed solution; and homogenizing, filling and sterilizing the mixed solution, so as to prepare the oral solution which is rich in nutrition and easy to absorb and has a beautifying skin-caring effect simultaneously when nourishing yin and supplementing blood. The preparation method is advanced in technology, reasonable in technique, strong in operability and suitable to large-scaled production.

The invention belongs to pure traditional Chinese medicine oral solutions and discloses a traditional Chinese medicine composition for resisting coccidiosis. The traditional Chinese medicine composition is composed of the following Chinese herbal medicine raw materials by part of weight: 290-310 parts of artemisia apiacea, 290-310 parts of antipyretic dichroa, 195-205 parts of root of Chinese pulsatilla and 195-205 parts of astragalus membranaceus. The traditional Chinese medicine composition for resisting coccidiosis is suitable for diseases of coccidiosis, and is fast and good in curing effect proved by the experiment, and is free of medicine residual compared with western medicines and free of side and toxic effects.

The invention discloses an iron-protein succinylate solubilizing method and an oral solution preparation thereof, which are used for solving the problems of difficulty in dissolving iron-protein succinylate into water, unstable solution and the like. In the method, lauryl sodium sulfate or poloxamer or PEG-400 or beta-cyclodextrin is taken as a solubilizing solvent, and 1,2-propylene glycol and the like are taken as latent solvents, so that the water solubility of the iron protein succinylate are increased, and the free iron content is less than 0.1 percent. An iron protein succinylate oral solution prepared by using a process disclosed by the invention is accordant with relevant regulations in the Imported Medicine Registration Standard JX20000298 and oral liquid dosage form items in the second version of the Chinese Pharmacopeia, edition 2010.

The present invention provides a polyethylene glycol-electrolyte oral solution. Its is made up by using 59-60 g of polyethylene glycol, 1.0-1.5 g of sodium chloride, 0.5-1.0 g of potassium chloride, 1.5-2.0 g of sodium hydrogen carbonate, 5.5-6.0 g of sedium sulfate, 0.02-0.5 g of egtazide, 0.02-0.5 g of sweetener and 1-2 ml of edible essence, and adding deionized water to 1000 ml. It mainly is applicable to colonoscopy, barium enema X-ray examination and intestinal tract ablution, etc. and also can be used for curing chronic constipation.

The invention discloses a pinocembrin and cyclodextrin or cyclodextrin derivative inclusion compound, wherein cyclodextrin or a cyclodextrin derivative is used to include the pinocembrin. The inclusion compound contains the pinocembrin and the cyclodextrin or cyclodextrin derivative in a molar ratio of 1:1-100. The inclusion compound can improve the water solubility of the pinocembrin and give good play of the therapeutic action of the pinocembrin. The inclusion compound is suitable for the preparation of sold dosage forms and liquid dosage forms required by clinics, including infusion solution, water injection, powder injection, oral solution, syrup, tablets, capsules, granules and dispersible tablets. The inclusion compound can be used for preparing drugs for preventing and\or treating cardiovascular and cerebrovascular diseases, particularly brain stroke, as well as drugs for preventing and\or treating bacterial and\or fungal infections.

The invention relates to a veterinary antibacterial drug composition containing lysozyme and oligosaccharide and an application thereof. The composition can be prepared into powder, granules, premixes, suspensions and oral solutions by mixing a pharmaceutically acceptable drug carrier with the main drugs of the lysozyme, the oligosaccharide and an antibacterial drug, as well as the auxiliary ingredients of biotin, phytic acid, trehalose, glycine and the like which are used for coordination, according to a conventional preparation method. The composition not only can enhance the self immunity of animals, equalize the absorption of amino acids and mineral substances in vivo and broaden the antimicrobial spectrum, but also has high efficiency, safety and no toxic and side effect and is not easy to lead to drug tolerance and drug resistance. The composition is used for preventing and treating intestinal diseases and respiratory diseases, such as colibacillosis, salmonellosis, pasteurella multocida, staphylococosis and the like, of livestock and poultry. Meanwhile, the developed drugs can be used for effectively substituting the traditional veterinary antibiotic drugs which are easy to lead to drug tolerance.

The invention discloses a traditional Chinese drug preparation for treating gastrokinetic insufficiency. The preparation comprises 19 drugs including 3g of ginseng, 15g of stir-fried rhizoma atractylodis alba, 10g of Tuckahoe, 3g of prepared radix glycyrrhizae, 20g of yam, 10g of herba cistanches, 10g of semen cuscutae, 10g of medlar, 5g of radix aconiti carmichaeli, 5g of rhizoma zingiberis, 10g of fructus aurantii immaturus, 30g of honey-fried radix astragali, 3g of pericarpium citri reticulatae, 10g of hawthorn, 10g of massa medicata fermentata, 10g of stir-baked fructus hordei germinates, 5g of stir-baked radix bupleuri with vinegar, 5g of radices saussureae and 10g of rhizoma ligustici wallichii. The traditional Chinese drug preparation can serve as an oral solution put into clinical application, is produced conventionally according to the production of oral solutions and has no special technical requirements and other accessories. The traditional Chinese drug preparation has reliable short-term curative effects, remarkable long-term curative effects and no relapse after recovery.

The present invention relates to compounds of Formula I and Formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of Formula I and Formula II; and formulated to treat an underlying etiology by oral administration, delayed release or sustained release, transmucosal, syrup, topical, parenteral administration, injection, subdermal, oral solution, rectal administration, buccal administration or transdermal administration.

The invention discloses a method for establishing an infantile stagnation-removing and cough-relieving oral solution-HPLC (High Performance Liquid Chromatography) fingerprint spectrum. The method comprises the following steps: preparing a tested product solution; determining an HPLC chromatographic condition; making an HPLC standard fingerprint spectrum. The invention also discloses the standard infantile stagnation-removing and cough-relieving oral solution-HPLC fingerprint spectrum obtained by adopting the method. The standard infantile stagnation-removing and cough-relieving oral solution-HPLC fingerprint spectrum has 19 common peaks, the relative retention times tR of the 19 common peaks are sequentially as follows: 0.066, 0.077, 0.088, 0.124, 0.157, 0.166, 0.192, 0.220, 0.229, 0.275, 0.481, 0.837, 0.872, 0.890, 0.962, 1.000, 1.026, 1.061 and 1.203. The method disclosed by the invention has the advantages of easiness and convenience for operation, high stability and good repeatability; the obtained spectrum has the multiple characteristic peaks, can be used for comprehensively evaluating the quality of an infantile stagnation-removing cough-relieving oral solution through the comparison of the common peaks of the standard fingerprint spectrum, is favorable to stabilizing the quality of products and ensuring the safety and the effectiveness of clinical medications.

The invention discloses a canzhiling oral solution fingerprint map building method. The map includes the following steps of preparation of a test solution, preparation of a reference solution, testing through a high performance liquid chromatograph and processing of data and a map. The invention further discloses a Canzhiling oral solution fingerprint map and a method for utilizing the fingerprint map to control quality of a Canzhiling oral solution. The Canzhiling oral solution fingerprint map building method is simple in operation, stable, reliable, high in accuracy and high in separation degree, the fingerprint map is high in stability and reproducibility and large in information quantity, and the fingerprint map is adopted as a quality control means for the Canzhiling oral solution, so that one-sidedness caused by judging of overall quality of a preparation by testing one or two chemical ingredients is avoided, and probability of artificial processing in order to enabling quality to be up to standards is lowered; samples of multiple batches are analyzed systematically, so that quality of the Canzhiling oral solution can be evaluated more comprehensively and scientifically, and product quality and efficacy are guaranteed.

The invention discloses a yang supplementing five returning ketoside drug for preventing and treating cardio-cerebrovascular diseases, which is prepared by extracting active ingredient from raw materials of hoantchy root, angelica, red paeonia, hemlock parsley, earthworm and peach kernel. The obtained drug has total glucosides of the hoantchy root as 30-60%, total glucosides oftotal glucosides of the red paeonia as 5-20%, content of safflower flavone as 5-10%, and the remains as the other ingredients extracted from the traditional Chinese medicine materials. The yang supplementing five returning ketoside drug provided by the invention can be added with accessories or auxiliary components acceptable in pharmacy to form various preparations required by clinic. The preparations are: small injection solution, transfusion, freeze-dried powder, tablet, capsule, oral solution, buccal tablet, granule, medicinal granules, pill, powder, suspension, suppository, drop, dropping pill, sustained release preparation, release controlling agent and targeting preparation. The drug of the invention has clearly controllable efficacious components, fast absorption, definitive curative effect, convenience for taking and is effective for preventing and treating cardio-cerebral ischemia diseases.

The invention discloses a method for combined extraction of mallow flavones and mallow saponins in seashore mallow, which is characterized by comprising the following steps of: taking the root tuber of fresh seashore mallow, and obtaining dry powder; carrying out ultrasonic treatment; extracting with 70% ethanol; removing the ethanol, and concentrating to obtain crude extracts of flavones and saponins; separating with macroporous resin; washing with water; eluting with 40% ethanol to obtain an eluent containing mallow flavones; then, eluting with 80% ethanol to obtain an eluent containing mallow saponins; and respectively concentrating and drying the two eluents. The mallow flavones and mallow saponins prepared by the method disclosed by the invention can be used for preparing health foods for preventing tumors or medicaments for treating tumors, and can be respectively or jointly prepared into powder, tablets, oral solutions, capsules and other foods or medicaments.

The invention provides a novel traditional Chinese medicinal compound Subing (quick effect heart rescue) spraying agent and its preparation method and belongs to the field of biomedicine, wherein the Subing (quick effect heart rescue) spraying agent has a good curative effect of resisting coronary angina pectoris. The problem of dissolving borneol with levant storax oil is solved by a new technology and a new method. The prescription is composed of styrax, borneol, a solubiliser, an absorption enhancer and a solvent. By the simple new technology of dissolution, homogenization and the like, borneol which is completely insoluble in water and levant storax oil which is not miscible with water phase are dissolved together in an oral water-soluble base so as to obtain an oral solution which is uniform and transparent without layers and suspension. The spraying agent or aerosol prepared in the invention can be quantitatively and directly sprayed into mouth or sprayed under tongue or directly sprayed into nasal cavity. In comparison with a solid preparation, the spraying agent prepared by styrax and borneol for oral administration has advantages of fast absorption and rapid effect, can perform a curative effect better and faster, is applicable to be taken by patients with angina pectoris during the acute phase. By the adoption of the preparation method provided by the invention, the effect onset time is greatly shortened within 60 seconds. The preparation method provides a good therapeutic novel medicine for currently high frequency and high occurrence of heart disease in our country.