170 results about "Capillary column" patented technology

The invention provides a method for detecting related substances of bromo-n-butane, which adopts a gas chromatography detection method, and the chromatographic conditions are as follows: a chromatographic column is a DB-624 quartz capillary column, and the specification is 30m * 0.32 mm * 1.8 [mu] m; the column temperature is 40 DEG C; the stationary phase is 6% of cyanopropyl phenyl-94% of dimethyl polysiloxane; the temperature of a sample injector is 250 DEG C; the sample size is 1 [mu] L; the split ratio is 20: 1; the carrier gas is nitrogen; the flow rate of nitrogen is 2.1 mL / min; a detector is a hydrogen ion spark detector, and the temperature of the detector is 250 DEG C. The invention further provides application of the method. The method can be used for rapidly and accurately detecting the related substances of the n-butyl bromide, realizes effective separation of the n-butyl bromide and impurities thereof, and is of great significance in improving the effective quality of the n-butyl bromide, controlling the content of the impurities brought into the synthesis reaction of the bupivacaine hydrochloride by the starting material and improving the quality stability of the bupivacaine hydrochloride.

The invention provides a capillary electrophoresis analysis method of serum amino acid. The capillary electrophoresis analysis method comprises the following steps: S1, preparing an operation buffer solution; s2, selection and pretreatment of a quartz capillary column; s3, conditions are analyzed through electrophoresis; s4, drawing a quasi curve; s5, sample derivatization; s6, quantitative analysis. According to the method, a mixed reagent of alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin is adopted for the first time, the amino acid migration behavior is cooperatively adjusted, a migration time window is expanded, the separation resolution of amino acids with similar structures is effectively improved, and the separation degree and the atlas definition are remarkably improved. According to the invention, sodium taurocholate is added, pH is regulated and controlled, a weakly alkaline buffer system with moderate conductivity and stable migration behavior is formed, separation and detection of FITC derived amino acids are facilitated, and balance of migration time distribution is optimized. The method is suitable for scenes of clinical sample analysis, disease marker screening and the like, and has good universality, stability and popularization value.

The embodiment of the invention provides a uniform temperature plate and a heat dissipation device, the uniform temperature plate comprises an evaporation capillary structure, a condensation capillary structure, a capillary column structure connected between the evaporation capillary structure and the condensation capillary structure, and a heat dissipation structure connected between the evaporation capillary structure and the condensation capillary structure, and the middle thickness of the condensation capillary structure is larger than the peripheral thickness of the condensation capillary structure. And the liquid working medium flows back to the evaporation capillary structure along the capillary column structure. According to the embodiment of the invention, the problem of dry burning or overlarge evaporation thermal resistance of the capillary structure of the vapor chamber in the prior art can be solved, the evaporation thermal resistance is reduced, the circulation heat dissipation efficiency of the phase change working medium is accelerated, dry burning of the capillary structure is prevented, and the heat transfer capacity of the vapor chamber is improved.

The present invention relates to the preparation and application of a micro-cell in-situ microreactor. By subjecting the inner wall of a capillary to silanization treatment and modifying epoxy groups on its surface through free radical polymerization reaction, an open-tubular capillary column is prepared. Then, polyethyleneimine and iodoacetic acid-N-succinimidyl ester are successively modified by covalent bonding to prepare a solid-phase alkylated capillary microreactor. The advantages of the present invention are that proteomic sample processing is carried out in-situ, which is conducive to reducing sample loss caused by multiple transfers during traditional sample processing. Therefore, this solid-phase alkylated open-tubular column is suitable for proteomic pretreatment of trace samples. In addition, this method is tolerant to various surfactants and strong lysis reagents and has good sample compatibility.

The invention discloses a detection method for simultaneously determining ethylene glycol and diethylene glycol in cetirizine hydrochloride drops, which comprises the following steps: step 1, setting chromatographic conditions: heating to 220 DEG C at a rate of 20 DEG C / min by using a capillary column with 6% propylphenyl-94% dimethyl polysiloxane as a stationary liquid, and maintaining for 10 minutes; step 2, solution preparation: preparing a blank solvent, a reference solution and a test solution; step 3, determination: taking the blank solvent, the reference substance solution and the test solution for sample introduction analysis, and recording a chromatogram; step 4, limit: calculating by peak area according to an external standard method, wherein the content of ethylene glycol is not more than 0.062%, and the content of diethylene glycol is not more than 0.025%; the method disclosed by the invention is simple, convenient, rapid, high in accuracy and good in specificity, can be used for simultaneously determining the contents of ethylene glycol and diethylene glycol in the cetirizine hydrochloride drops, and is suitable for quality research and control of the cetirizine hydrochloride drops.

According to the method for detecting the content of the volatile substances in the aquilaria sinensis, provided by the invention, through pretreatment steps such as extraction of an extraction solvent, heating reflux and filtration, a sample is selectively and preliminarily purified, and the matrix effect of subsequent detection and analysis is effectively reduced; an inert capillary column is used for separation, high-purity helium is used as carrier gas, and an optimized heating program and an MRM detection mode are combined; through the synergistic effect of the two components, comprehensive, accurate and high-repeatability qualitative and quantitative analysis of various volatile substances in the aquilaria sinensis, especially nookatone which is easy to leak in a conventional method, is realized, and a reliable technical means is provided for accurate identification and quality evaluation of the aquilaria sinensis.

The present application relates to a controllable preparation method of a colloidal crystal capillary column and its application in biomolecule separation, and specifically comprises the following steps: a plunger and an electroosmotic pump are prepared in situ at one end of a capillary; a buffer solution containing monodisperse colloidal particles is filled in an upper reservoir of an electric field assembly device, and a buffer solution is filled in a lower reservoir; the capillary is filled with the buffer solution, and the end of the capillary containing the electroosmotic pump is inserted into the lower reservoir; the dispersion of the colloidal solution is maintained by applying oscillation to the upper reservoir, an electric field is applied between the two reservoirs to make the colloidal particles move to the electroosmotic pump under the action of an electroosmotic flow, and a three-dimensional colloidal crystal is assembled; and the capillary is supplemented with an ultrasonic force to reduce lattice defects. The present application has the advantages of simple preparation process, controlled directional movement of colloidal particles through an electric field, improved assembly efficiency and quality of the three-dimensional colloidal crystal, and controllable assembly of the colloidal particles under the action of an electric field through regulation and control of the length and surface charge of the electroosmotic pump.

This invention discloses a two-phase liquid-cooled heat dissipation device, comprising a heat absorption module, a heat dissipation module, a delivery pipe section, and a return pipe section. The heat absorption module, delivery pipe section, heat dissipation module, and return pipe section are sequentially connected end-to-end to form a closed-loop cavity. A cooling chamber is provided outside the closed-loop cavity within the heat dissipation module, and the heat dissipation module is provided with a cooling connector. A capillary column is provided inside the closed-loop cavity within the heat absorption module. One end face of the capillary column has a first channel recessed therein, and the other end face of the capillary column has a second channel recessed therein. The opening of the first channel faces the return pipe section, and the opening of the second channel faces the delivery pipe section. The distance between the first channel and the inner wall of the closed-loop cavity is greater than the distance between the second channel and the inner wall of the closed-loop cavity. Liquid returns into the capillary column, and through the unidirectional vapor-liquid action of the capillary column, the working fluid flows unidirectionally within the closed-loop cavity, avoiding mutual disturbance between the vapor and the return liquid, improving the flow efficiency of the working fluid, and enhancing the heat dissipation capacity of the device.

The utility model provides a capillary column cleaning device, which relates to the technical field of gas chromatography devices and comprises a bottom plate, a fixing frame, a first capillary frame, a second capillary frame, a capillary hollow column, a solvent bottle, a waste liquid bottle and a gas circuit control device. The first capillary frame and the second capillary frame are adjacently installed in buckles on the fixing frame, the solvent bottle is installed on a bottom plate between the first capillary frame and the second capillary frame, the waste liquid bottle is installed on a bottom plate on one side of the second capillary frame, the capillary hollow column is installed on the first capillary frame, and the air inlet end of the capillary hollow column is connected with the air path control device. According to the gas chromatography capillary column cleaning device disclosed by the invention, the problems that the existing gas chromatography capillary column cleaning device is complicated in design structure, the capillary column is tedious to clean, and the existing gas chromatography capillary column cleaning device is inconvenient to use in a common laboratory can be solved.

The invention discloses a method for detecting related substances of tribromoacetone by gas chromatography, which belongs to the technical field of chemical detection, the related substances of tribromoacetone are detected by gas chromatography, an instrument is a gas chromatograph, a detector is an FID detector, a capillary column taking 100% methylpolysiloxane (MEGA-1) as a stationary liquid is used as a chromatographic column, carrier gas is N2, the flow velocity is 2.0 mL / min, the split ratio is 50: 1, and the detection time is 30 minutes. Temperature programming: the initial temperature is 80 DEG C, and the temperature is raised to 250 DEG C at the rate of 10 DEG C per minute and maintained for 10 minutes; a sample injection mode is as follows: direct sample injection is performed, the temperature of a sample injection port is 260 DEG C, and the temperature of a detector is 280 DEG C; according to the present invention, the sample introduction volume is 0.2 [mu] l, the related substances in the tribromoacetone can be effectively separated, the content of the related substances can be quantitatively detected, the acetone, the bromoacetone, the 1, 3-dibromoacetone and the 1, 1, 3, 3-tetrabromoacetone sequentially appear peaks, and the method has characteristics of simple operation, strong specificity, good repeatability, good intermediate precision and good durability, and can accurately and rapidly determine the content of the various related substances in the tribromoacetone.

The invention belongs to the technical field of medicine detection, and particularly relates to a method for determining enantiomers in a levocarnitine intermediate by gas chromatography. The method for determining the enantiomer in the levocarnitine intermediate by the gas chromatography comprises the following steps: taking a capillary column which takes dimethyl polysiloxane bonded with cyclodextrin as a stationary liquid as a chromatographic column; the method comprises the following steps: dissolving and diluting a test product (R)-4-chloro-3-hydroxy ethyl butyrate by using ethyl acetate, and deriving by adding acetic anhydride and pyridine to prepare a test product solution; and injecting the test solution into a gas chromatograph, recording a chromatogram, and calculating the content of the enantiomer (S)-4-chloro-3-hydroxybutyric acid ethyl ester in the levocarnitine intermediate (R)-4-chloro-3-hydroxybutyric acid ethyl ester according to an area normalization method. The method for determining the enantiomer in the levocarnitine intermediate by the gas chromatography provided by the invention is accurate and fast in detection, and provides a basis for quality control of levocarnitine.

The invention relates to the technical field of traditional Chinese medicine detection, in particular to a method for determining the content of various components in blumea balsamifera oil. According to the method, a gas chromatography-mass spectrometry (GC-MS) technology is adopted, and chromatographic conditions are as follows: a chromatographic column is an SH-Stabilwax (30m * 0.32 mm, and the film thickness is 0.25 [mu] m) capillary column; the temperature of a sample inlet is 230 DEG C; the split ratio is 10: 1; the sample size is 1 microliter; the mass spectrum conditions are as follows: the ion source temperature is 200 DEG C; the interface temperature is 230 DEG C; the ionization mode is electron impact ion (EI); the detection voltage is 0.2 KV; the solvent is delayed for 2 minutes; the mass number scanning range is 30 to 400 amu; and SIM mode. According to the method disclosed by the invention, the contents of alpha-pinene, camphene, beta-pinene, limonene, p-cymene, camphor, alpha-coumarin, linalool, bornyl acetate, beta-caryophyllene, myrtenal, alpha-caryophyllene, L-borneol, perillaldehyde, caryophyllene oxide, guaiacol, beta-eudesmol and xanthoxylin in the blumea balsamifera oil can be simultaneously determined; the method provided by the invention has good precision, repeatability and stability, and the quality consistency of the blumea balsamifera oil can be quickly, accurately and effectively evaluated through detection of multiple components.

The invention discloses a method for determining the purity of tert-butyl-(S)-[2-(2-cyano-4, 4-difluoropyrrolidine-1-yl)-2-oxyethyl] carbamate, which adopts a gas chromatographic method, adopts a capillary column which takes (5%-phenyl)-95% methylpolysiloxane copolymer as a stationary liquid as a gas chromatographic column, and adopts a temperature rising procedure to detect the purity of tert-butyl-(S)-[2-(2-cyano-4, 4-difluoropyrrolidine-1-yl)-2-oxyethyl] carbamate. And after the sample introduction, calculating the purity of the tert-butyl-(S)-[2-(2-cyano-4, 4-difluoropyrrolidine-1-yl)-2-oxyethyl] carbamate according to a peak area normalization method, so as to obtain the tert-butyl-(S)-[2-(2-cyano-4, 4-difluoropyrrolidine-1-yl)-2-oxyethyl] carbamate. According to the method, the purity of Boc-Fapi-a is detected by adopting a gas chromatography temperature programming method, so that the influence of weak UV response signals and different response intensities of various impurity components can be avoided, the technical blank of lack of an effective chromatographic detection method for the substance at present is filled up, the convenient quality control is realized, and the detection requirement is met.

The invention belongs to the technical field of gas chromatography detection, and relates to a gas chromatography method for simultaneously determining the content of ethanol and isopropyl myristate. The set conditions of the gas chromatography are as follows: the temperature of an FID detector and a polyethylene glycol 20M capillary column is 240-260 DEG C, the temperature of the detector is 240-260 DEG C, the carrier gas is nitrogen, the flow rate is 0.9-2.5 mL / min, the sample injection amount is 1 mu L, the column temperature is increased by adopting a program, the initial temperature is 80-90 DEG C, the temperature is increased to 180-190 DEG C at the rate of 9-12 DEG C / min, and the temperature is maintained for at least 10 minutes. The method provided by the invention can realize simultaneous detection of ethanol and isopropyl myristate, after the two substances are dissolved by the N, N-dimethylformamide solvent, the detected spectrogram does not have the phenomena of peak overlapping, trailing and the like, and the method has the advantages of high separation efficiency, high selectivity, high sensitivity, high analysis speed and wide application range.

The application discloses a method for determining industrial methyl perfluoroisobutyrate by gas chromatography, adopts a 60m capillary column with a stationary phase of (6% -cyanopropyl-phenyl) methyl polysiloxane, and cooperates with a specific programmed temperature condition and a headspace sampling mode to simultaneously separate three impurities of dimethyl carbonate, perfluoroisobutyryl fluoride and methyl perfluoropropionate, the resolution of each component is greater than 1.5, and the quantitative detection limit of dimethyl carbonate is less than or equal to 0.05%. The application realizes quantitative detection by a blank correction standard curve method, has the characteristics of strong separation capacity, high sensitivity, good precision and simple operation, and is suitable for multi-component synchronous quality detection of industrial methyl perfluoroisobutyrate products.

The invention discloses a method for detecting NDMA in a famotidine injection by adopting gas chromatography-mass spectrometry. The method comprises the following steps: detecting a to-be-detected sample of the famotidine injection by adopting gas chromatography-mass spectrometry; the parameter conditions of the gas chromatography are as follows: a capillary column taking polyethylene glycol (or similar polarity) as a stationary liquid is taken as a chromatographic column; the temperature of a sample inlet is 190-210 DEG C; the heating procedure is as follows: the initial temperature is 54-66 DEG C, and the temperature is kept for 0.5-1.5 minutes; the temperature is raised to 235-245 DEG C at the temperature raising rate of 15-25 DEG C / min, and the temperature is kept for 0 min; the parameter conditions of the mass spectrum are as follows: the acquisition type is SRM; the ion source is EI; the solvent delay is 0 min; the temperature of the transmission line is 235-245 DEG C; and the temperature of the ion source is 245-255 DEG C. The method is simple to operate, high in detection speed, low in detection limit and high in reliability.

Some embodiments described herein relate to capillary-containing cartridges suitable for use with capillary electrophoresis instruments. Embodiments described herein generally relate to cartridges that include a transfer capillary coupled to a separation capillary. The transfer capillary can be configured to be disposed in sample reservoirs and / or buffer reservoirs. Suction applied through a sheath interface of the transfer capillary and the separation capillary can draw sample / buffer from such reservoirs and bring the sample / buffer into contact with the separation capillary. The separation capillary can be configured for separation of analytes contained within the sample, for example when an electric potential (i.e., voltage) is applied across the separation capillary.

The invention belongs to the technical field of analysis and detection, and particularly relates to a sulfur hexafluoride isotope abundance detection method. The sulfur hexafluoride isotope abundance detection method provided by the invention comprises the following steps: detecting a to-be-detected sample by using a gas chromatograph-mass spectrometer to obtain a total ion flow chromatogram of sulfur hexafluoride; the gas chromatography test conditions are as follows: a DB-5MS capillary column is adopted, the split ratio is (20-80): 1, and the sample size is 1-10 L; the mass spectrum test conditions comprise that the voltage of a multiplier is + 300 to + 600, and the half-peak width is less than 0.6; and carrying out < 32 > SF < 5 + >, < 33 > SF < 5 + > and < 34 > SF < 5 + > ion extraction on the total ion chromatogram of sulfur hexafluoride to respectively obtain the peak area of < 32 > SF < 5 + >, the peak area of < 33 > SF < 5 + > and the peak area of < 34 > SF < 5 + >, and calculating the abundance of < 32 > SF < 5 + >, the abundance of < 33 > SF < 5 + > and the abundance of < 34 > SF < 5 + >. The detection method provided by the invention has the advantages of economical efficiency, high analysis speed and high accuracy.

The invention provides a gas phase detection method for simultaneously determining six chlorine-based disinfectant byproducts in serum. The gas phase detection method comprises the following steps: S1, liquid-liquid extraction-acidification methanol derivatization pretreatment; s2, instrument detection: S21, chromatographic conditions: a 6890N gas chromatograph and a DB-1701 capillary column are adopted, the temperature of a sample inlet is 200-250 DEG C, and the temperature of a detector is 280-320 DEG C; s22, carrying gas and flow velocity; s23, temperature programming conditions are set; according to the method, by optimizing detection conditions, the recovery rate of the HAAs is increased, and the detection limit of the method is reduced, and the method is proper in sensitivity, small in sample usage amount, simple and convenient to operate and capable of being widely applied to detection of the HAAs in clinical large-scale queues and serum.

The invention relates to the field of analytical chemistry, and particularly discloses a method for determining residual solvents N, N-dimethylformamide, dichloromethane, isopropanol, ethyl acetate, methyl tert-butyl ether, ethanol, acetone, tetrahydrofuran and ethylene glycol dimethyl ether in a litamilast raw material by adopting a headspace-gas chromatography method, and a method for determining residual solvents N, N-dimethylformamide, dichloromethane, isopropanol, ethyl acetate, methyl tert-butyl ether, ethanol, acetone, tetrahydrofuran and ethylene glycol dimethyl ether in a litamilast raw material by adopting a headspace-gas chromatography method. The method comprises the following steps of: detecting by using a capillary column with 6 percent of cyanopropyl phenyl-94 percent of dimethyl polysiloxane as a stationary liquid through headspace sample introduction gas chromatography and a flame ionization detector (FID). According to the method disclosed by the invention, nine residual solvents contained in the litamilast raw material can be completely separated in one system, the separation degree is greater than 1.5, the specificity is good, interference from blank solvents and other unknown impurities is avoided, the sensitivity is high, the detection accuracy is high, and the quality of litamilast can be effectively controlled.

The invention discloses a method for determining the residual quantity of petroleum ether in an isonicotinamide benzonate bulk drug by using capillary gas chromatography, and belongs to the technical field of drug analysis. According to the method, an external standard method is adopted for quantification, a 6% cyanopropyl phenyl-94% dimethyl polysiloxane capillary column is used as a chromatographic column, and an FID detector is adopted for detection; the residual quantity of the petroleum ether is the total residual quantity of normal hexane, 2-methylpentane and 3-methylpentane in the petroleum ether. The method disclosed by the invention is good in specificity, good in linearity, reliable in accuracy and high in sensitivity; the gas chromatographic method can be used for rapidly, effectively, accurately and reliably separating and detecting the residual amount of petroleum ether in the isopropylamine bulk drug, and is beneficial to improving the product quality of the isopropylamine bulk drug and improving the medication safety of a patient.

The invention discloses a GM806 gas chromatograph system and an operation method, and the system comprises a sample introduction module which is used for collecting a target sample through an automatic sample introduction device and selecting a separation column for accurate sample introduction; the separation module is used for performing component separation on the target sample through a separation column; the detection module is used for detecting the separated sample components, acquiring detection data and calibrating and checking the detection data; and the analysis module is used for analyzing the calibrated and checked detection data and generating an analysis report of the target sample according to an analysis result. The high-efficiency capillary column is used, an optimized temperature control program is combined to realize high-efficiency separation of a complex sample, the separation efficiency and the separation effect are improved, meanwhile, low-concentration component detection is realized by setting the sensitivity of a detector, and reliable detection of all components of a target sample can be comprehensively realized; and the detection efficiency, comprehensiveness, practicability and stability are improved.

The present invention discloses a capillary gas chromatography column for realizing baseline separation of xylene isomers, and a preparation method and application thereof. The stationary phase of the capillary gas chromatography column is a nano material with a multi-level pore structure, and nano particles are uniformly embedded in the inner wall of the capillary column. The prepared nano material is dissolved in an organic solvent, dynamically coated in a capillary chromatography column at a constant flow rate, and finally cured at high temperature to obtain the capillary chromatography column. The capillary column is used for separation of xylene isomers, and the position / para position separation is as high as 15.2. At the same time, the prepared capillary gas chromatography column can achieve excellent separation effects for other benzene substituted isomers and alkane isomers, providing a new solution for the efficient separation of such isomers.

The invention belongs to the technical field of medicine detection, and particularly relates to a method for detecting and analyzing dimethyl sulfate in potassium sulfate serving as a raw material of a sodium potassium magnesium sulfate concentrated solution, the method adopts gas chromatography, and the chromatographic conditions are as follows: a chromatographic column is a capillary column of a non-polar stationary phase; the temperature programming control is as follows: the initial temperature of the column temperature is controlled to be 40-60 DEG C, the holding time is 2-5 minutes, the temperature is raised to 120-140 DEG C at the rate of 5-20 DEG C / min, then the temperature is raised to 230-280 DEG C at the rate of 15-25 DEG C / min, and the holding time is 5-15 minutes; the temperature of a sample inlet is 240-280 DEG C; the temperature of a detector is 250-350 DEG C. The method provided by the invention can detect the content of dimethyl sulfate in potassium sulfate, does not appear in the existing detection method, and can make up the technical blank in the field. The analysis method provided by the invention is good in specificity, high in repeatability, low in detection limit and high in accuracy.

The present invention provides a gas chromatography-mass spectrometry detection method for hexachlorobenzene and decachlorobiphenyl in thiophanate-methyl. The gas chromatography-mass spectrometry detection method comprises: preparing a hexachlorobenzene-decachlorobiphenyl standard working solution and a thiophanate-methyl sample solution; separating and detecting the hexachlorobenzene-decachlorobiphenyl standard working solution and the thiophanate-methyl sample solution by gas chromatography and mass spectrometry, wherein the gas chromatography adopts a DB-5ms capillary column and is performed in a split injection mode; obtaining a hexachlorobenzene standard curve and a decachlorobiphenyl standard curve according to the detection results of the gas chromatography and mass spectrometry, and obtaining the content of ultra-trace hexachlorobenzene and decachlorobiphenyl in the thiophanate-methyl sample solution in combination with the standard curve. The gas chromatography-mass spectrometry detection method can simultaneously and sensitively and rapidly measure the content of ultra-trace hexachlorobenzene and decachlorobiphenyl in high-purity thiophanate-methyl, saves analysis costs, has high analysis efficiency, and is suitable for the determination of ultra-trace hexachlorobenzene and decachlorobiphenyl content in large quantities of thiophanate-methyl products.

The invention provides a method for detecting methyl lactate in a sodium lactate solution, a gas chromatography is combined with a headspace sampling technology, and chromatographic conditions are as follows: a chromatographic column is a capillary column taking polyethylene glycol or a compound with similar polarity as a stationary liquid; a sample inlet is 180 DEG C, and headspace sample injection is performed; a flame ionization detector is adopted, and the temperature is 230 DEG C; the carrier gas is nitrogen, the flow velocity is 2.0 ml / min, and the split ratio is 10: 1; the column temperature program is as follows: 35 DEG C is maintained for 3 minutes, the temperature is raised to 90 DEG C at 5 DEG C / min and maintained for 3 minutes, and then the temperature is raised to 200 DEG C at 15 DEG C / min and maintained Headspace conditions are as follows: the balance temperature of a headspace bottle is 90 DEG C, and the time is 30 minutes; a quantitative loop is 100 DEG C; the temperature of the transmission line is 110 DEG C; the circulation time is 40 minutes. The method can accurately and quantitatively detect methyl lactate, is convenient to operate, and has great significance in improving the quality control level of the sodium lactate solution, guaranteeing the application safety of the sodium lactate solution in the fields of medicines and foods and perfecting a quality standard system.

The utility model provides a multifunctional integrated chromatographic analysis device. The multifunctional integrated chromatographic analysis device comprises a sample injection unit, a chromatographic analysis unit and a control unit, wherein the sample injection unit is used for sample injection of probe molecules; the separation unit comprises a capillary column and a temperature control box, and the input end of the capillary column is connected with the output end of the sample introduction unit through a first switching valve; the testing unit comprises a three-way valve, a plurality of sample columns and at least one reference column; the carrier gas unit comprises a carrier gas pipeline and a carrier gas interface, one end of the carrier gas pipeline is connected with the carrier gas interface, and the other end is connected with the output end of the capillary column; the detection unit comprises a first detector and a second detector which are respectively connected with the sample outlet ends of the sample column and the reference column. The analysis device disclosed by the utility model is convenient, simple and efficient to use, can be used for gas chromatography and multi-channel surface energy analysis, and can integrate multi-probe separation and multi-channel surface energy analysis, so that the use flexibility of the analysis device is greatly improved, the test range is expanded, the test process is greatly shortened, and the test efficiency is improved.

Capillary tube assemblies and methods of construction and use are disclosed, including a capillary tube assembly comprising a capillary tube, a plunger, and a grip. The capillary tube has first and second tube ends, a bore, and a longitudinal axis extending between the first and second tube ends. The plunger has a first plunger portion disposed within the bore and a second plunger portion disposed outside of the bore. The plunger is slidably disposed within the bore to be selectively moved toward the first tube end along the longitudinal axis. The grip has first and second grip ends, an opening extending between the first and second grip ends, and a recess in fluid communication with the opening and engaging the second tube end to connect the capillary tube to the grip. The recess has a channel extending between the recess and the second grip end forming a vent.

The invention discloses a method for detecting a residual solvent in cefazolin sodium, which comprises the following steps of: performing gas chromatography detection by adopting a headspace sampling mode, recording a chromatogram, and performing quantitative analysis on the chromatogram by adopting an external standard method. Wherein the chromatographic column is a capillary column taking polyethylene glycol (or similar polarity) as a stationary phase or a gas-phase capillary chromatographic column with equivalent efficiency; in the heating procedure, the initial temperature ranges from 30 DEG C to 40 DEG C and is maintained for 5 minutes, and the temperature is increased to 200 DEG C at the speed of 10 DEG C per minute and maintained for 2 minutes; the sample size is 1 microliter. The detection method provided by the invention has good specificity and system adaptability, good sample injection precision, extremely low detection limit and quantitation limit, good durability, good linearity, good accuracy and very high sensitivity, and can be widely applied to quality control of the cefazolin sodium product.

The invention discloses a method for determining the content of hydrogenated bisphenol A epoxy resin and application of the hydrogenated bisphenol A epoxy resin, and the method comprises the following steps: determining a hydrogenated bisphenol A epoxy resin standard solution by adopting a thermal cracking-gas chromatography-mass spectrometer, and drawing a standard working curve, the gas chromatographic column is a capillary column chromatographic column of which the filler is (50%-phenyl)-methylpolysiloxane or a capillary column chromatographic column of which the filler is polyethylene glycol; testing the sample by adopting the same step as the step of determining the hydrogenated bisphenol A epoxy resin standard solution; and calculating the content of hydrogenated bisphenol A epoxy resin in the sample according to the obtained standard working curve. According to the method, hydrogenated bisphenol A epoxy resin can be cracked into hydrogenated bisphenol A, so that the hydrogenated bisphenol A epoxy resin in a sample (such as a sealant) can be quantitatively analyzed.