The invention belongs to the technical field of detection of
traditional Chinese medicine preparations, and particularly relates to a
quality control method of Jindan attached-extending granules, the
quality control method adopts UHPLC-MS / MS-QAMS technology to determine the content of multiple components of
corydalis tuber in the Jindan attached-extending granules, the
quality control method comprises the following steps: firstly, preparing a
test solution and a reference solution; respectively measuring the
test solution and the reference solution by using UHPLC-MS / MS, recording the
peak area, and calculating the
relative correction factor and content of each component by using
tetrahydropalmatine as an internal reference substance. According to the method, the
tetrahydropalmatine is determined by adopting UHPLC-MS / MS-QAMS through a quantitative analysis of multi-components by single marker, indirect determination of other various related components is realized, the method is low in detection cost, high in sensitivity, strong in specificity and short in analysis time, whether
corydalis amabilis is doped in the rhizoma
corydalis decoction pieces fed in the production of the Jindan attached-
delay granules or not can be well distinguished, and the quality of the Yindan attached-
delay granules is ensured. And a basis is provided for
quality monitoring of the Jindan Qingyuan granules.