The invention relates to a degradation agent of the pesticide residue of Chinese herbal medicine and a production method thereof, which utilizes mirco-nano biological coating technology, enzyme active substance control and a stabilization system of active plant cell film and assists with an intelligent slow/controlled release adjuvant, thus promoting crop output and quality, degrading hazardous substances of the pesticide residue and enhancing products to achieve the international standards. The invention contains the components of oligosaccharide, selenic acid lipopolysaccharide, plant humic acid, rare earth, pectin, phytoalexin, organic matters, abscisic acid, vanillic aldehyde, amino acid, boracic acid, zinc sulfate, nicotinamide, sodiumnitro phenolate, phytic acid, ferrous sulfate, lycine, gibberellinn and chelated calcium; process water is added in sequence according to the weight mixture ratio; the mirco-nano technology is adopted and a product is obtained through coating, enveloping, technique processing treatment of mirco-nano structure, dynamic dissolution, high-pressure spray homogenization, filtering, mixing and reaction.