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Method for preparing vitamin A and vitamin E nano-sphere/microsphere double-embedding system

A vitamin and nanosphere technology, which is applied to medical preparations containing active ingredients, pharmaceutical formulations, metabolic diseases, etc., can solve the problems of difficult preservation, difficult processing, and the inability of wall materials to provide slow-release effects, so as to avoid mutual Interfere and improve the effect of bioavailability

Inactive Publication Date: 2008-07-09
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For a single fat-soluble vitamin, most domestically choose hydrophilic wall materials for embedding, but this type of wall material cannot provide effective slow-release effect. When the wall material meets water (such as saliva), it is dissolved, resulting in core material massive release of
Wang Hua et al. prepared vitamin A microcapsules by composite coacervation method, but the post-treatment process of composite coacervation method is difficult and difficult to preserve. Even after spray drying, the capsule particles are no longer round, but aggregated together.
So far, there is no report on double-layer embedding of vitamin A and vitamin E in China

Method used

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  • Method for preparing vitamin A and vitamin E nano-sphere/microsphere double-embedding system

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Accurately weigh 20g of monoglyceride, heat it to melt at 70°C, accurately weigh 5g of vitamin A oil, add it to the melted monoglyceride, stir and mix. Accurately weigh 160g of octenyl succinic esterified starch (modified starch Hi-CAP100) added with Tween-80, dissolve it in 600mL of water at 70°C, add molten monoglyceride added with vitamin A to the modified In the starch Hi-CAP100 solution, stir vigorously and disperse at high speed (10000r / min, 30s). Accurately weigh 55g of vitamin E oil, add it to the above-mentioned modified starch solution, disperse at high speed (20500r / min, 1min), and homogenize at high pressure (40MPa), repeat 3 times, all operations are carried out at 70°C. Rapidly cool in an ice-water bath to below the melting point of monoglyceride, spray-dry, the air inlet temperature is 190°C, and the air outlet temperature is 90°C to obtain a nanosphere / microsphere double embedding system embedding vitamin A and vitamin E.

Embodiment 2

[0019] Accurately weigh 42g of monoglyceride, heat it to melt at 70°C, accurately weigh 10.5g of vitamin A oil, add it to the melted monoglyceride, stir and mix. Accurately weigh 340g of modified starch Hi-CAP100, dissolve it in 1050mL of water at 70°C, add the molten monoglyceride added with vitamin A into the modified starch Hi-CAP100 solution, stir vigorously, and disperse at high speed (10000r / min, 30s). Accurately weigh 52g of vitamin E oil, add to the above modified starch solution, high-speed dispersion (20500r / min, 1min), high-pressure homogenization (60MPa), repeat 3 times, all operations are carried out at 70 ° C. Rapidly cool in an ice-water bath to below the melting point of monoglyceride, spray-dry, the air inlet temperature is 190°C, and the air outlet temperature is 90°C to obtain a nanosphere / microsphere double embedding system embedding vitamin A and vitamin E.

Embodiment 3

[0021] Accurately weigh 30g of beeswax, and heat it to melt at 78°C. Accurately weigh 7.5g of vitamin A, add to the melted beeswax, stir and mix. Accurately weigh 150g of modified starch Hi-CAP100, dissolve it in 570mL of water at 78°C, add molten beeswax with added vitamin A into the modified starch Hi-CAP100 solution, stir vigorously, and disperse at high speed (10000r / min, 30s ). Accurately weigh 39g of vitamin E, add to the above-mentioned modified starch solution, high-speed dispersion (20500r / min, 1min), high-pressure homogenization (50MPa), repeat 3 times, all operations are carried out at 78 ° C. Rapidly cool in an ice-water bath to below the melting point of beeswax, spray dry, the air inlet temperature is 185°C, and the air outlet temperature is 85°C to obtain a nanosphere / microsphere double embedding system embedding vitamin A and vitamin E.

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Abstract

A preparation method of vitamin A and vitamin E nano-sphere / microsphere double-embedding system belongs to the technical field of biological active substance control release microencapsulation. In the present invention, food grade vitamin A is nano-sphere core material and monoglyceride or beeswax is nano-sphere wall material to be made into nano-sphere suspension which is used as microsphere core material together with the vitamin E; ocentyl succinate esterified starch containing tween-80 is used as microsphere wall material; the nano-sphere / microsphere double-embedding system is manufactured by a thermal homogenization-spray drying method. The encapsulation rate towards the vitamin A of vitamin A nano-sphere manufactured by the present invention can reach to 82 percent to 94 percent, and the particle size of the nano-sphere is 200nm to 370nm. The encapsulation rate towards the vitamin A of the double-embedding system is 86 percent to 91 percent and the encapsulation rate towards the vitamin E is 89 percent to 93 percent. The double-embedding system can embed the vitamin A and the vitamin E synchronously and has the effect of releasing step be step, so as to avoid the mutual interference of active components, improve the biological utilization rate and can be added into various foods as vitamin intensifier and extender.

Description

technical field [0001] The invention discloses a preparation method of a nanosphere / microsphere double embedding system of vitamin A and vitamin E, which belongs to the technical field of microencapsulation for controlled release of biologically active substances. Background technique [0002] Vitamin A is an essential nutrient element for normal human growth and development, bone formation, normal vision and immune system maintenance. It has the functions of anti-lipid peroxidation, enhancing immunity, enhancing anti-infection, regulating fat storage, and improving iron deficiency anemia. Vitamin A deficiency (vitamin A deficiency, VAD) is a public nutritional problem in many developing countries. Vitamin A deficiency increases morbidity and mortality from various infectious diseases, respiratory diseases and diarrhea. [0003] Vitamin E is a fat-soluble natural antioxidant, which inhibits lipid peroxidation by inactivating the activity of peroxidative free radicals or rea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/14A61K31/07A61K31/355A61P3/02
Inventor 许时婴夏书芹许婧朱卫红
Owner JIANGNAN UNIV
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