33results about How to "Achieve sustained release" patented technology

The invention belongs to the field of biological medicines, and relates to a drug-loaded nano-vesicle as well as a preparation method and application thereof. The drug-loaded nano-vesicle comprises a vesicle core and a drug-loaded nano-vesicle, wherein the vesicle core comprises siRNA (small interfering Ribonucleic Acid) capable of specifically targeting and silencing an NR1D1 gene; the vesicle membrane is formed by fusing an erythrocyte membrane, a macrophage membrane, cardiolipin, cholesterol and lecithin. The drug-loaded nano-vesicle can specifically target macrophages in a sepsis immunosuppression stage, has an intracellular response release function, recovers BMAL1 and IGF2BP2-ATP6V1B2 / ATP6V0c axis functions by inhibiting NR1D1 expression, reconstructs a macrophage phagocytosis function and lysosome-dependent bacterium removal capability, and can be used for preparing a drug-loaded nano-vesicle with a specific targeting function. The survival rate of sepsis immunosuppression model animals is obviously improved; and the bacterial load is reduced. Compared with a traditional electroporation method, the preparation method disclosed by the invention has the advantage that the encapsulation efficiency of siRNA is remarkably improved.

This invention provides an antibacterial and antistatic leather surface treatment agent, its preparation method, and its application, relating to the field of functional coatings technology. The treatment agent uses a water-based fluorocarbon-acrylic copolymer resin as a base material, and combines carbon nanotubes and conductive carbon black to construct a three-dimensional conductive network, which can stabilize the surface resistance of leather at 10 Ω·cm. 7 -10 8 This Ω-based antistatic agent exhibits superior long-lasting antistatic properties compared to traditional ionic antistatic agents. Simultaneously, it synergistically combines water-based thorium compounds with nano-titanium dioxide to form a highly efficient antibacterial system, achieving an antibacterial rate of >99.9% against Escherichia coli and Staphylococcus aureus within 24 hours, and still >95% after 6 months, thus solving the problem of short-lasting effectiveness of traditional antibacterial agents. As a water-based system, this treatment agent has VOC emissions <30g / L, meeting environmental protection requirements and satisfying the comprehensive needs of the automotive interior leather products industry for long-lasting antistatic, highly efficient antibacterial, and environmentally friendly performance.

This invention belongs to the field of disposable hygiene products technology, specifically disclosing a disposable underwear with antibacterial function and its preparation method. The invention involves constructing a three-layer structure: a moisture-wicking layer, a moisture-wicking-absorbent layer, and an antibacterial-moisture-wicking layer. Different properties are imparted to different structures. The moisture-wicking layer and the moisture-wicking-absorbent layer constitute the inner lining layer, mainly achieved by modifying cotton fibers and coating one side of the modified cotton fibers to enhance moisture wicking performance and create a dry microenvironment, thus preventing bacterial growth at the source and achieving an antibacterial effect. The antibacterial-moisture-wicking layer constitutes the pant body layer. By introducing sodium alginate (SA) and ε-polylysine, sodium alginate (SA) not only acts as a "binder" but also cross-links with ε-polylysine to form a stable three-dimensional network structure, "fixing" the antibacterial factors within its structure to achieve the antibacterial purpose. This invention effectively solves the problems of poor antibacterial effect and insufficient moisture wicking in traditional disposable underwear.

The invention relates to the technical field of biomedical materials and tissue engineering, and discloses sequential slow-release temperature-sensitive hydrogel and a preparation method and application thereof.The preparation method comprises the following steps that a blood sample is subjected to programmed centrifugation, and a gel layer of leukocyte-rich platelet-rich fibrin L-PRF and a gel layer of improved platelet-rich fibrin A-PRF are obtained respectively; and the gel layer is cut into pieces, pre-frozen, freeze-dried, ground and sieved, so that L-PRF freeze-dried powder and A-PRF freeze-dried powder are obtained respectively, and the methacrylic acid gelatin microspheres entrapped with the L-PRF freeze-dried powder are prepared. The microspheres and A-PRF freeze-dried powder are loaded into a temperature-sensitive hydrogel system composed of chitosan, polygalacturonic acid and sodium beta-glycerophosphate, so that the growth factors can be effectively entrapped in the hydrogel structure, and continuous release is realized; the system has good mechanical strength and structural stability, the retention time of the material in vivo is prolonged, and stable three-dimensional network support is provided.

The application discloses a multifunctional injectable hydrogel and a preparation method and application thereof, and relates to the technical field of multifunctional hydrogel preparation and application. In the preparation, CMC-AGE and OD-SH are prepared respectively, and DSPE-se-se-PEG@AC NPs nanoparticles are prepared, then the multifunctional injectable hydrogel is prepared by forming a hydrogel through CMC-AGE and OD-SH and adding DSPE-se-se-PEG@AC NPs nanoparticles and / or beta nerve growth factor. The application also includes the multifunctional injectable hydrogel prepared by the above method and the application thereof. The application constructs an in-situ hydrogel delivery platform with good biocompatibility, is used for co-delivery of DSPE-se-se-PEG@AC NPs and NGF, is used in ischemic stroke treatment, and reshapes the pathological microenvironment of a cerebral infarction area, so that cerebral ischemic injury is reduced.

The invention discloses Fe (at) MoS2 hydrogel for sensitizing immunotherapy and a preparation method of the Fe (at) MoS2 hydrogel. The hydrogel comprises ferrous sulfate, molybdenum disulfide and a hyaluronic acid hydrogel matrix. The hydrogel can continuously release iron ions in a tumor slightly acidic environment, Fe is reduced into Fe by utilizing the catalytic action of MoS, and circular supply of Fe is realized, so that tumor cells are efficiently and enduringly induced to generate ferroptosis. More importantly, it is found that the Fe-coated MoShydrogel can specifically up-regulate expression of IL-36 gamma and CXCL2 in a tumor microenvironment for the first time, and by activating an IL36 gamma / CXCL2 / CXCR2 signal axis, mononuclear macrophages are recruited and remodeled, and the immunosuppression microenvironment is reversed. In-vivo experiments show that when the hydrogel is combined with an immune checkpoint inhibitor (such as an alphaPD-1 antibody), a remarkable synergistic anti-tumor effect can be generated, and the complete remission rate is greatly improved.

This invention discloses a method for enhancing the waterlogging tolerance of sesame seedlings using melatonin and its application. The method utilizes alginate oligosaccharides, boric acid, melatonin, calcium chloride, polyalkylene oxide-modified heptamethyltrisiloxane, and deionized water as raw materials. Through a stepped temperature control and multi-channel synchronous assembly process, a cross-linked network is constructed to physically encapsulate melatonin, effectively shielding its photosensitive area to slow down UV photolysis. This method features low surface tension, allowing easy penetration into microcracks and stomata on plant leaves. After a small amount of water evaporates, an in-situ sol-gel phase transition is triggered, forming a hydrogel microfilm that adheres to the leaf tissue, resisting natural rainfall washout and achieving slow-release of melatonin. This invention effectively solves the problems of easy loss and photolysis of conventional exogenous agents, and the components synergistically activate basic plant immune and antioxidant pathways, systematically enhancing the waterlogging tolerance of sesame seedlings.

This invention discloses a bio-fermentation tank system for the harmless treatment of livestock and poultry manure and its usage method, belonging to the field of manure bio-fermentation treatment technology. The system includes an inclined and rotatable fermentation tank, an openable and closable cover, and supporting components. An installation plate with microbial filler holes is embedded inside the tank, with the holes pre-filled with adsorption substrate to fix the microbial community. A rotatable turbulence component is provided, which pushes the manure into the cutting chamber, where it is squeezed and segmented before flowing back to the main chamber, achieving cyclic treatment. The system is equipped with an independent gas control structure, supporting switching between aerobic and anaerobic fermentation modes. Through the synergistic effect of tank rotation and internal turbulence, thorough mixing of manure, mechanical cutting, and slow-release contact with the microbial community are achieved, significantly improving degradation efficiency and harmless treatment effect. This invention solves the problems of uneven mixing, low microbial activity, poor solid-liquid separation, and incomplete resource conversion in traditional processes, and is suitable for the efficient, harmless, and resource-based treatment of large-scale manure.

The application discloses a kind of all mixed sheep feed and preparation method thereof, belong to the technical field of feed.The preparation method includes: using constant temperature and humidity closed treatment cooperates with compound detoxification agent to cottonseed for detoxification treatment, preparation rumen steady state amino acid composite carrier and cellulose carrier load composite enzyme, then modified cottonseed, composite carrier, load composite enzyme are mixed with basic mixture, after conditioning, granulation obtains all mixed sheep feed.The application is through mild detoxification process, and cottonin removal and protein protection are considered, and rumen nutrient release synchronization is realized using bentonite slow-release carrier and microcrystalline cellulose immobilized composite enzyme, and essential oil and enzyme preparation are protected from processing heat inactivation.The obtained feed realizes the efficient full replacement of cottonseed to soybean meal, significantly improves the growth performance and feed conversion efficiency of Bayinbuluke black head sheep, and reduces the breeding cost.

The invention belongs to the technical field of medicines, and particularly relates to a microneedle patch for disguising a macrophage cell membrane and a preparation method of the microneedle patch. Degradable high polymer material nano-particles camouflaged by the macrophage membrane are embedded in a microneedle array of the microneedle patch camouflaged by the macrophage membrane, and the degradable high polymer material nano-particles camouflaged by the macrophage membrane are wrapped with gambogic acid and oleic acid functionalized cerium dioxide nano-particles. Nanoparticles of the microneedle patch jointly load gambogic acid and oleic acid functionalized cerium dioxide, through microneedle transdermal drug delivery, active targeting of the drug to the liver is achieved by using natural inflammatory taxis of a macrophage membrane, the anti-inflammatory effect of gambogic acid and the anti-oxidation effect of cerium dioxide are synergistically exerted, polarization of macrophages is adjusted, and the anti-inflammatory effect of the drug on the liver is achieved. Therefore, the liver injury caused by the septic shock is treated.

The invention discloses a preparation method of an isolating and soothing non-woven fabric and a disposable hygienic product. The method comprises the following steps that the surface of an ES fiber net is pretreated, so that a nanoscale net-shaped pre-coating layer with positive charges is formed on the fiber surface; a dynamic slow-release composite mineralization layer is constructed outside the nanoscale net-shaped pre-coating layer; and constructing a gradient pore structure on the fiber net loaded with the mineralization layer. According to the invention, ES fiber is taken as a base material, and a dynamic slow-release composite system is adopted, so that anti-inflammatory factors are embedded into the biomimetic mineralization layer, and continuous release of components is realized; a gradient pore ventilation structure is constructed, and pore size distribution with dense top and sparse bottom is formed through a two-way stretching process, so that rapid infiltration of liquid is ensured, and good air permeability is maintained; and a self-crosslinking bonding interface is developed, so that the surface layer and the absorption core body are chemically bonded after being in contact with the liquid, and the isolating and relieving effects are achieved.

The invention belongs to the technical field of natural medicine extracts, and relates to a polygonatum sibiricum flower bud extract as well as a preparation method, a microcapsule preparation and application thereof. The polygonatum sibiricum flower bud extract contains one or more of rutin, apigenin-6-arabinose-8-glucoside, and apigenin-6, 8-diglucoside, and is characterized in that the polygonatum sibiricum flower bud extract contains one or more of rutin, apigenin-6-arabinose-8-glucoside and apigenin-6, 8-diglucoside. By utilizing the preparation method of the polygonatum sibiricum flower bud extract and the preparation method of the microcapsule preparation, the polygonatum sibiricum flower bud extract and the microcapsule preparation of the polygonatum sibiricum flower bud extract can be better prepared respectively; the prepared polygonatum sibiricum flower bud extract and the microcapsule preparation of the polygonatum sibiricum flower bud extract can better inhibit the activity of alpha-glucosidase in vivo and in vitro, and can be used for preventing or treating diabetes mellitus with better curative effect and smaller side effect.

The invention relates to the technical field of traditional Chinese medicine concentrated pills and preparation thereof, in particular to traditional Chinese medicine concentrated pills for treating cardiovascular and cerebrovascular diseases and a preparation method of the traditional Chinese medicine concentrated pills. The concentrated traditional Chinese medicine pill is prepared from the following raw materials in parts by weight: radix astragali seu hedysari, ginseng under forest, radix ophiopogonis, fructus schizandrae, radix paeoniae rubra, semen persicae, cortex moutan, radix angelicae sinensis, poria cocos, rhizoma chuanxiong, saffron crocus, salvia miltiorrhiza bunge, pseudo-ginseng and the like, wherein the radix astragali seu hedysari, the salvia miltiorrhiza bunge and the ginseng under forest are prepared into standard fermented traditional Chinese medicine powder through a micro-fermentation process combining an ancient method and a modern method; and carrying out low-temperature full-wall-breaking superfine grinding on the other raw materials to obtain superfine powder. Through cooperation of low-temperature wall-breaking superfine grinding, controllable micro-fermentation and solid dispersion slow-release forming, effective components are released more sufficiently, absorption is more stable, batch-to-batch consistency is better, taking is more convenient, and better storage stability is achieved.

This invention discloses a vitamin A-functionalized polyphenol-phospholipid complex, its preparation method, and its applications, belonging to the field of pharmaceutical formulation and nanodelivery technology. The phospholipid complex comprises a polyphenol drug, a phospholipid material, and a vitamin A phospholipid ligand. The vitamin A phospholipid ligand is formed by vitamin A or its derivatives and a phospholipid derivative containing amino or other reactive groups. The phospholipid complex forms a phospholipid composite structure through non-covalent interactions between the polyphenol drug and the phospholipid material, and the vitamin A phospholipid ligand is inserted into or assembled into the surface or interior of the phospholipid composite structure. Animal experiments show that this phospholipid complex can reduce serum transaminase levels and alleviate the degree of liver fibrosis, and has good blood compatibility and tissue safety. This invention provides an industrially achievable targeted nano-formulation solution for early intervention in liver fibrosis, with promising application prospects.

The invention discloses a composite composition with a scalp care effect and application thereof, the composition is composed of a cacumen biotae extract, a yucca extract, a towel gourd extract and a sargassum fusiforme extract, and the preparation process of the composite composition ensures excellent stability and permeability through composite enzymatic hydrolysis, ultrasonic extraction and high-pressure homogenization treatment. The composition provided by the invention effectively solves the problems that active ingredients are difficult to permeate, hair follicle growth is promoted and the like, and is suitable for developing hair products such as shampoo, hair conditioners, hair nourishing liquid, scalp essence and the like.

This invention relates to the field of liquid soap technology, specifically to a mite-removing sulfur liquid soap and its processing technology, comprising the following steps: Step 1: Dissolve sodium hydroxide in 6%~8% of the total mass of the liquid soap with water to prepare a sodium hydroxide solution for later use; dissolve 80%~90% of a thickener in 10%~20% of the total mass of the liquid soap with water to prepare a thickener solution for later use; Step 2: Homogenize and disperse the remaining water, surfactant, and humectant until evenly mixed; lower the temperature, add preservative, remaining thickener, modified sulfur, shea butter, fragrance, traditional Chinese medicine extract, soapberry extract, and emulsifier, and mix and stir until evenly mixed to obtain a mixture; Step 3: Mix the mixture, sodium hydroxide solution, and thickener solution evenly to obtain the mite-removing sulfur liquid soap. The mite-removing sulfur liquid soap prepared by this invention improves the stability of sulfur in liquid soap and has a good mite-removing effect, reducing skin problems caused by mites.

The invention discloses an integrated patch for wound pH detection and nitric oxide gas treatment and a preparation method of the integrated patch, relates to a biomedical engineering device, and is used for pH monitoring and nitric oxide (NO) treatment at a wound. According to the system, the pH value of a wound is monitored in real time by adopting a colorimetric method, and a micro light-emitting diode (LED) is used as a switch to control the release of nitric oxide, so that slow-release treatment of low-concentration nitric oxide can be realized, and sterilization treatment can be performed under a high-concentration condition. The patch specifically comprises a flexible circuit and a PVA film, and wireless gas therapy is realized through light by fixing an NO donor in the PVA film. According to the invention, ultrasonic energy can be collected in a living body and is converted into an electric signal based on a piezoelectric effect, so that wireless energy supply is realized. According to the invention, slow release and rapid release of NO can be realized, and different requirements in medical scenes can be realized.

The invention discloses a preparation method of a high-oil-phase solid plant-based fat analogue, which comprises the following steps: adding hydrophobic modified chitosan gel into a soybean protein isolate solution, then adding linseed oil and transglutaminase into the homogenized mixed solution, carrying out enzymatic crosslinking, and then putting into a calcium chloride solution for ionic crosslinking. According to the preparation method disclosed by the invention, a network structure is formed by carrying out enzyme induction on soybean protein isolate, and a double-network structure is formed by introducing hydrophobic modified chitosan microgel through ionic crosslinking and is used as a structural framework, so that the technical bottleneck that a stable three-dimensional network is difficult to form by traditional emulsion gel under a high-oil-phase condition is successfully broken through; the obtained fat analogue shows a highly compact and uniform microstructure, key texture parameters such as hardness, adhesion and chewiness of the fat analogue are remarkably improved along with structural optimization, high unification of high oil phase load and high-strength texture is realized, and solid taste and morphological stability of animal fat can be truly simulated.

This invention provides a hydrogel-based precision delivery system for acupuncture needles, its preparation method, and its application, belonging to the field of biomedical materials technology. The hydrogel-based precision delivery system for acupuncture needles includes an acupuncture needle and a hydrogel coating. A threaded groove is formed on the needle body, and the hydrogel coating adheres to this groove. The hydrogel coating is prepared by photocrosslinking N-[2-(3,4-dihydroxyphenyl)ethyl]-2-methylacrylamide and methacrylated hyaluronic acid to obtain an adhesive hydrogel, which is then encapsulated in a liposome and loaded into the threaded groove. After drying, the hydrogel coating is formed. The hydrogel-based precision delivery system provided by this invention enables the smooth, minimally invasive delivery of drugs or biological materials to the subchondral bone via the acupuncture needle, regulating abnormal TGF-β1 secretion and constructing stem cell migration channels in the subchondral bone, achieving precise localization and treatment of the subchondral bone.

The application discloses an intestinal-targeted controlled-release microalgae pharmaceutical composition, which comprises a hydrophobic drug, a micellar material and microalgae, wherein the hydrophobic drug is first loaded on the micellar material to form a drug-loaded micelle, the solubility of the hydrophobic drug is improved, and the drug-loaded micelle solution penetrates into the interior of the microalgae cells through a passive water absorption process of dried microalgae instead of being attached to the surface of the microalgae. The natural cell wall of the microalgae itself is solid and acid-resistant, which is used as a first physical barrier to prevent the release of the hydrophobic drug in a gastric acid environment, and the effective concentration and residence time of the hydrophobic drug in the intestinal action site are significantly improved, so that the treatment effect is better, and the intestinal disease and kidney disease drug can be prepared.

This invention belongs to the field of pharmaceutical preparation technology, specifically relating to a hyaluronic acid-modified co-supported nanoparticle, its preparation method, and its application. The nanoparticle has a core-shell structure, with the core being a coordination complex of zinc-doped Prussian blue and sinomenine hydrochloride, and the outer shell being a bovine serum albumin-hyaluronic acid conjugate. This invention improves the therapeutic effect on knee osteoarthritis.

The application discloses a programmable drug release anti-infection and bone formation promoting multifunctional orthopedic internal implant device and a preparation method thereof. The implant is prepared according to the following steps: 1) introducing a titanium nanotube (TNT) structure on the surface of a titanium alloy base by using an anodic oxidation method; 2) sequentially loading an anti-infection component, a bone formation promoting factor and a blood vessel formation promoting factor into the TNT tube by using a vacuum sequential loading process; and 3) finally, coating a poly-tannic acid (PTA) coating on the surface of the material base by using a tannic acid (TA) in-situ self-polymerization technology. The multifunctional bone implant device can sequentially release the anti-infection drug, the blood vessel formation promoting factor and the bone formation promoting factor in the order of the vacuum drug loading, and the modified surface of the device has good drug release and oxidation resistance, so that the bone infection can be efficiently prevented and treated, and the bone repair efficiency is improved.

This invention belongs to the field of feed additive technology, specifically relating to a microalgae compound feed additive for alleviating weaning stress in calves and its preparation method. The microalgae compound feed additive comprises the following raw materials in parts by weight: 5-10 parts microalgae powder, 2-6 parts unsaturated fatty acid / modified montmorillonite complex, 0.7-1.2 parts probiotics, and 0.3-0.5 parts walnut shell extract. This microalgae compound feed additive can improve the fragile intestinal barrier function and immunity of weaned calves, enhance their growth performance, and thus improve breeding efficiency.

The application discloses a kind of oral sustained-release composition of edaravone, preparation method and application.The application provides a kind of pharmaceutical composition, it includes tablet core and coating;The tablet core includes drug-containing layer tablet core and / or boost layer tablet core;The drug-containing layer tablet core includes edaravone pharmaceutical active ingredient and carrier;The carrier is one or more in polymer carrier, osmotic pressure regulator, swelling agent, thickening agent and lubricant;The boost layer tablet core includes one or more in osmotic pressure regulator, swelling agent, colorant and lubricant.The pharmaceutical composition of the application maintains 24 hours sustained-release, oral convenient, blood drug concentration is stable, avoids the method of 2 times intravenous drip in a day, improves patient compliance.In addition, the pharmaceutical composition, prescription and preparation process are simple, easy to industrial production.

The invention relates to the technical field of vaccine adjuvants and drug delivery, and discloses a 3D-MLA and QS-21 composite adjuvant as well as a preparation method and application of the 3D-MLA and QS-21 composite adjuvant. A saponin QS-21; polyethylene glycol sodium alginate; embedding particles with pH-sensitive calcium chloride; the preparation method of the vaccine antigen comprises the following steps: performing pegylation modification on sodium alginate; embedding calcium chloride with a pH sensitive polymer, and carrying out spray drying to prepare cross-linking agent particles; dissolving the synthetic monophosphoryl lipid A and saponin QS-21 to prepare a composite adjuvant solution; mixing the adjuvant solution with the pegylated sodium alginate solution to prepare a precursor preparation; and adding antigen and cross-linking agent particles into the precursor preparation, and uniformly mixing to obtain a final product. According to the invention, the composite adjuvant is delivered through the pH responsive in-situ gel, an immune reservoir is formed, and a powerful and lasting comprehensive immune response biased to the Th1 type is safely induced.

The invention relates to a sprayable lipid liquid crystal gel precursor containing a periplaneta americana freeze-dried concentrate as well as a preparation method and application thereof, belongs to the technical field of pharmaceutical preparations, and solves the problems that an existing gel dosage form containing a periplaneta americana extract adopts a water-based gel matrix with high water content, a high-dose preservative needs to be added, and the cost is high. And the damaged skin is possibly stimulated. The lipid liquid crystal gel precursor comprises the following main active ingredients in percentage by mass: 1%-6% of periplaneta americana freeze-dried concentrate, 0.05%-1% of SOD (superoxide dismutase), 0.5%-3% of triethanolamine, 20%-30% of SPC (sodium phosphate), 50%-60% of GDO (glucose dissolved oxygen) and 5%-15% of absolute ethyl alcohol. The preparation method comprises the following steps: 1, preparing a liquid crystal matrix phase and an active component phase; and 2, uniformly mixing the liquid crystal matrix phase and the active component phase according to a mass ratio of (85-90): (10-15) to obtain the lipid liquid crystal gel precursor.

The present application relates to a kind of RSL3 loaded liposome-hydrogel composite delivery system, which is composed of hydrogel matrix and liposome nanoparticle uniformly dispersed in it in physical embedding manner, the liposome nanoparticle is formed by the encapsulation of ferroptosis inducer RSL3 in liposome carrier, and the liposome carrier is a lipid bilayer vesicle formed by assembling DSPC, cholesterol and DSPE-PEG2000;The hydrogel matrix is a three-dimensional porous network structure formed by Schiff base cross-linking reaction of carboxymethyl chitosan and oxidized hyaluronic acid.The present application also provides the application of the composite delivery system in the preparation of contraceptive drugs.Experiments in vivo and in vitro prove that the composite delivery system can achieve complete contraception, and the uterus is normal, liver and kidney function is normal, reproductive function is completely reversible, and the development index of offspring is qualified.The present application realizes non-hormonal, reversible and locally safe contraceptive effect by inducing trophoblast cell ferroptosis, and provides a new solution for the development of contraceptive technology.

The invention relates to the field of liquid foliar fertilizer preparation. The invention relates to a preparation method of a special efficient iron-supplementing stress-resistant liquid foliar fertilizer for flowers, which comprises the following steps of: preparing ferrous carbonate by double decomposition reaction: adding ferrous sulfate and ammonium bicarbonate into deionized water at 20-28 DEG C, and reacting under a stirring condition to obtain a ferrous carbonate turbid liquid with the pH value of 6.2-6.8; adjusting the pH value of the ferrous carbonate turbid liquid to 4-6 by using an acetic acid or sodium acetate buffer solution, then adding disodium ethylene diamine tetraacetate into the ferrous carbonate turbid liquid, heating to 40-45 DEG C, and forming an EDTA-Fe < 2 + > chelating solution under a stirring condition; cooling the EDTA-Fe < 2 + > chelating liquid to room temperature, sequentially adding polyglutamic acid, sodium lignin sulfonate and boric acid, and uniformly stirring to obtain the efficient iron-supplementing stress-resistant liquid foliar fertilizer special for flowers. According to the invention, the contradiction that the traditional fertilizer can not promote the flower when supplementing iron and can not resist stress when promoting the flower is solved.

The application discloses a temperature-sensitive liposome hydrogel for targeting controllable release of a drug carrier and a preparation method and application thereof, and belongs to the field of liposome hydrogels.The method comprises the following steps: (1) dispersing polysaccharide in water, then adding polyvinyl alcohol, stirring uniformly, and then freezing / thawing the obtained mixed solution for multiple times to obtain a physically cross-linked hydrogel, and then eluting and soaking the hydrogel to obtain the hydrogel; (2) uniformly oscillating a liposome emulsion and the hydrogel, and obtaining the liposome hydrogel through centrifugation and freeze-drying.The application solves the problems that the liposome as a drug carrier is influenced by external environment and temperature conditions, and the targeting characteristics for some diseases are not ideal, and the phenomena of drug leakage and poor effect are caused.The application also realizes the effects of controllable release of a drug and improvement of drug bioavailability, and has a higher drug release amount at a temperature of 42 DEG C.

The invention belongs to the technical field of biomedical engineering materials, and discloses a nano composite hydrogel for diabetic bone repair and a preparation method thereof.The preparation method comprises the steps that oxidized hyaluronic acid is prepared and modified through phenylboronic acid to obtain OHA-PBA; then preparing a halloysite nanotube loaded with bulbus lilii glycoside B; and finally, uniformly mixing an OHA-PBA aqueous solution with the RB-HNT powder, adding a polyvinyl alcohol aqueous solution, and constructing a dynamic cross-linked network through reversible borate bonds formed by phenylboronic acid and hydroxyl groups and hydrogen bonds formed by the hydroxyl groups on the surface of the RB-HNT and the polymer. The nano-composite hydrogel disclosed by the invention has diabetes pathology microenvironment responsiveness, can be controllably degraded under high glucose, ROS or acidic conditions, slowly releases RB and silicon ions, and synergistically exerts antioxidant, anti-inflammatory and osteogenesis promoting effects; meanwhile, excellent injectability and self-healing ability are achieved, the material can be attached to irregular bone defect parts, and minimally invasive drug delivery is achieved.