78results about How to "Achieve sustained release" patented technology

The invention relates to the technical field of agricultural fertilizers, and particularly discloses a magnesium aluminum silicate mineral derived layered magnesium aluminum bimetallic oxide-silicon oxide composite material as well as a preparation method and application of the magnesium aluminum silicate mineral derived layered magnesium aluminum bimetallic oxide-silicon oxide composite material. Magnesium / aluminosilicate minerals are successfully converted into the layered magnesium-aluminum bimetal oxide-silicon oxide composite material with a high specific surface area and a developed pore structure, and the layered magnesium-aluminum bimetal oxide-silicon oxide composite material is combined with nutrients through a simple and convenient fertilizer preparation process to prepare the slow-release fertilizer. The slow-release fertilizer has the advantages of cheap and easily available raw materials, simple and efficient preparation process, stable slow-release performance, soil improvement effect and the like, and provides an efficient and environment-friendly new way for development of the slow-release fertilizer; the method has important significance for promoting sustainable agricultural development and realizing high-value utilization of silicate minerals in the agricultural field.

The invention relates to the field of medical patches, and discloses a controlled-release long-acting fever cooling patch which comprises a temperature response type material layer located on the outermost side of the fever cooling patch and used for triggering rapid release of medicine when the body temperature rises; the medicine composite layer is located on the inner side of the temperature response type material layer and used for compounding the antipyretic medicine and the traditional Chinese medicine ingredients together through a carrier, providing stable release of the medicine and enhancing the medicine effect; the invention also discloses a preparation method of the controlled-release long-acting fever cooling patch, which comprises the following steps: preparing the temperature response type material layer, dissolving the poly (N-isopropylacrylamide) or the copolymer thereof in a proper amount of solvent, coating the surface of the patch substrate with the solution, and drying to obtain the temperature response type material layer. The multi-layer composite structure is combined with the temperature and humidity response type material, so that the sustained release and long-acting antipyretic effect of the medicine are realized, the medicine release rate is automatically adjusted, the lasting and stable antipyretic effect is ensured, the medicine waste is reduced, and the convenience and comfort are improved.

The invention provides a preparation method and application of magnesium L-threonate, and belongs to the technical field of medicines. The preparation method comprises the following steps: dissolving L-ascorbic acid in water, adding magnesium hydroxide and alkaline magnesium carbonate, stirring, dropwise adding hydrogen peroxide, heating, stirring and reacting, filtering a product, purifying and concentrating by temperature-sensitive molecularly imprinted hydrogel while the product is hot, adding an ethanol water solution into a concentrated solution, standing, crystallizing, filtering, washing and drying to obtain the magnesium L-threonate. And cooling the temperature-sensitive molecularly imprinted hydrogel after adsorption to room temperature, washing and repeatedly using the temperature-sensitive molecularly imprinted hydrogel. The magnesium L-threonate is simple in preparation method, high in purity and high in yield, meanwhile, the slow-release magnesium L-threonate is prepared, and the magnesium L-threonate is low in toxicity, good in biocompatibility, large in drug loading capacity, low in economic cost and good in drug effect and has wide application prospects in preparation of anti-depression drugs.

The invention belongs to the field of biological medicines, and relates to a drug-loaded nano-vesicle as well as a preparation method and application thereof. The drug-loaded nano-vesicle comprises a vesicle core and a drug-loaded nano-vesicle, wherein the vesicle core comprises siRNA (small interfering Ribonucleic Acid) capable of specifically targeting and silencing an NR1D1 gene; the vesicle membrane is formed by fusing an erythrocyte membrane, a macrophage membrane, cardiolipin, cholesterol and lecithin. The drug-loaded nano-vesicle can specifically target macrophages in a sepsis immunosuppression stage, has an intracellular response release function, recovers BMAL1 and IGF2BP2-ATP6V1B2 / ATP6V0c axis functions by inhibiting NR1D1 expression, reconstructs a macrophage phagocytosis function and lysosome-dependent bacterium removal capability, and can be used for preparing a drug-loaded nano-vesicle with a specific targeting function. The survival rate of sepsis immunosuppression model animals is obviously improved; and the bacterial load is reduced. Compared with a traditional electroporation method, the preparation method disclosed by the invention has the advantage that the encapsulation efficiency of siRNA is remarkably improved.

According to the nitrogen hydrochloride # imgabs0 # stine eye drops for treating allergic conjunctivitis and the preparation method of the nitrogen hydrochloride # imgabs0 # stine eye drops, the prepared eye drops can interact with the mucous layer on the surface of keratoconjunctiva by selecting specific solid lipid and a surfactant and controlling the dosage of the solid lipid and the surfactant; the retention capacity of the medicine in front of the cornea is prolonged, so that the medicine has good targeting property, the continuous release of the medicine is realized, the medication frequency can be reduced, the toxic and side effects of the medicine are reduced, the bioavailability is improved, the medication compliance of a patient is enhanced, and in the preparation and long-term storage processes, the medicine has better stability, and is suitable for popularization and application. Therefore, the problems of excessive drug due to multiple administration and poor stability of the active component nitrogen hydrochloride # imgabs1 # stine are solved.

The invention discloses a precipitation-supported coated slow-release carbon-based iron fertilizer and a preparation method thereof.The preparation method specifically comprises the steps that a biological crustacean heavy metal adsorbent is soaked in a ferrous sulfate solution and then soaked in a calcium hydroxide solution again after low-temperature drying, finally, dried particles are granulated and subjected to coating treatment, and the coated slow-release carbon-based iron fertilizer is obtained. The coated slow-release iron fertilizer is loaded in a precipitation mode, a mixture of precipitated ferric hydroxide and ferrous hydroxide is uniformly dispersed and attached to the interiors of pore channels of the porous adsorbent, and the precipitated ferric hydroxide and the ferrous hydroxide are wrapped by a byproduct calcium sulfate in the porous adsorbent, so that long-acting slow release of iron ions can be realized; the rice cadmium arsenic antagonistic iron fertilizer has the advantages that the rice cadmium arsenic antagonistic effect can be achieved, the oxygen content of soil can be reduced, fine quantitative use of the coated iron fertilizer in the seedling raising period is matched, iron ion antagonism and a precipitation type adsorption load mode are carried out in the whole rice growth process, the iron ion release period is greatly prolonged, and the iron fertilizer has the excellent rice cadmium arsenic antagonism effect and has the excellent application prospect.

The invention relates to the field of new biological materials, in particular to a high-packaging-dose antibacterial slow-release biological patch obtained by packaging at least two antibiotics with an acellular matrix material. The acellular matrix material is derived from any two of small intestinal submucosa, peritoneum, dermis, bladder basement membrane and pericardium; the antibiotics comprise hydrophobic antibiotics and hydrophilic antibiotics, and the hydrophobic antibiotics are selected from one or more of Beta-lactam antibiotics, rifamycin and macrolide antibiotics; the hydrophilic antibiotics are tetracycline antibiotics. The coating-free drug-loaded sustained-release system based on a lamination process kills bacteria in a short period, prevents colonization and reproduction of bacteria in a wound / patch, realizes synergistic and continuous release of antibiotics along with a wound healing process, guides tissue regeneration and synchronously realizes degradation, is applied to a high-incidence infection period of a surgical operation, reduces adhesion, and has a good application prospect. The abdominal wall strength is enhanced, and the growth of wound granulation tissues is promoted.

The invention relates to the technical field of drug delivery, and mainly relates to a water-in-water-in-water emulsion for drug delivery and a preparation method and application thereof. The preparation method comprises the following steps: preparing an anionic polysaccharide aqueous solution, and dissolving a medicine in the anionic polysaccharide aqueous solution to obtain a mixed solution; preparing a cationic polysaccharide aqueous solution or a protein aqueous solution; and adding the mixed solution into a cationic polysaccharide aqueous solution or a protein aqueous solution, mixing, and emulsifying to obtain the water-in-water-in-water emulsion for drug delivery. The water-in-water-in-water emulsion with high stability and excellent biocompatibility is successfully prepared through the synergistic effect of the cationic polysaccharide or the protein and the anionic polysaccharide without any emulsifier, and the unique particle structure of the emulsion is combined with a charge conversion mechanism to regulate and control drugs, realize slow release and prolong the drug effect time.

The invention belongs to the technical field of medicines, and particularly relates to a linarin targeted slow-release nano drug-loading system as well as a preparation method and application thereof. A polylactic acid-polyglycolic acid copolymer is used as a matrix, polyvinyl alcohol is used as a cross-linking agent, and coated drug-loaded microspheres are formed through cross-linking and grafting of the matrix and the cross-linking agent; and then chitosan is used as a protective agent, chitosan and the coated drug-loaded microspheres are crosslinked and grafted to form double-coated composite drug-loaded microspheres, the chitosan in the composite drug-loaded microspheres is used as a shell, the coated drug-loaded microspheres are used as a core, and the linarin targeted slow-release nano drug-loaded system is obtained. Through the double-target design, the targeting property to cornea and lacrimal gland is enhanced, the treatment efficiency of the medicine is improved, stable release and continuous release of linarin are realized, and the problem of unstable release of the medicine is solved; in addition, the targeted slow-release nano drug-loading system is combined with the anti-inflammatory activity and the mitochondrial protection function of linarin, so that the side effects on eyes are reduced, and the safety is improved.

This invention provides an antibacterial and antistatic leather surface treatment agent, its preparation method, and its application, relating to the field of functional coatings technology. The treatment agent uses a water-based fluorocarbon-acrylic copolymer resin as a base material, and combines carbon nanotubes and conductive carbon black to construct a three-dimensional conductive network, which can stabilize the surface resistance of leather at 10 Ω·cm. 7 -10 8 This Ω-based antistatic agent exhibits superior long-lasting antistatic properties compared to traditional ionic antistatic agents. Simultaneously, it synergistically combines water-based thorium compounds with nano-titanium dioxide to form a highly efficient antibacterial system, achieving an antibacterial rate of >99.9% against Escherichia coli and Staphylococcus aureus within 24 hours, and still >95% after 6 months, thus solving the problem of short-lasting effectiveness of traditional antibacterial agents. As a water-based system, this treatment agent has VOC emissions <30g / L, meeting environmental protection requirements and satisfying the comprehensive needs of the automotive interior leather products industry for long-lasting antistatic, highly efficient antibacterial, and environmentally friendly performance.

This invention belongs to the field of disposable hygiene products technology, specifically disclosing a disposable underwear with antibacterial function and its preparation method. The invention involves constructing a three-layer structure: a moisture-wicking layer, a moisture-wicking-absorbent layer, and an antibacterial-moisture-wicking layer. Different properties are imparted to different structures. The moisture-wicking layer and the moisture-wicking-absorbent layer constitute the inner lining layer, mainly achieved by modifying cotton fibers and coating one side of the modified cotton fibers to enhance moisture wicking performance and create a dry microenvironment, thus preventing bacterial growth at the source and achieving an antibacterial effect. The antibacterial-moisture-wicking layer constitutes the pant body layer. By introducing sodium alginate (SA) and ε-polylysine, sodium alginate (SA) not only acts as a "binder" but also cross-links with ε-polylysine to form a stable three-dimensional network structure, "fixing" the antibacterial factors within its structure to achieve the antibacterial purpose. This invention effectively solves the problems of poor antibacterial effect and insufficient moisture wicking in traditional disposable underwear.

The invention discloses aztreonam microspheres as well as a preparation method and application thereof. The microsphere is an inhalation preparation and can be effectively deposited in the lung, so that the slow release of the medicine is realized. According to the aztreonam microspheres, aztreonam and cinnamyl aldehyde are synthesized into a small molecule drug, and the small molecule drug is self-assembled into the microspheres. The preparation method comprises the following steps: (1) placing aztreonam AZT and cinnamyl aldehyde CA in a glass bottle according to a molar ratio of 3: 2, adding dimethyl sulfoxide DMSO, stirring and dissolving, and stirring and reacting at room temperature for 5-7 hours; (2) dialyzing the reacted solution in a dialysis bag, removing DMSO and unreacted small molecules, and obtaining dialysate after 48 hours; (3) performing freeze drying to obtain yellow powder of cinnamyl aldehyde-aztreonam CAT; and (4) weighing the CAT powder, dissolving the CAT powder in deionized water, and shaking to dissolve the CAT powder to obtain the aztreonam microspheres. The microspheres are suitable for treatment of pulmonary infections, in particular for local drug delivery and sustained release control.

The invention discloses an application of a secretory curl-associated protein 2 gene as a new target for treating uterine scars, the secretory curl-associated protein 2 gene (sFRP2) promotes the progress of the uterine scars, interferes, silences and inhibits the uterine scars, and the sFRP2 is knocked out, so that the occurrence and development of the scar uterus can be relieved, the pregnancy rate of women can be increased, and the adverse pregnancy outcome can be reduced. In order to further improve the curative effect that sFRP2 gene expression is inhibited by sFRP2-targeted small interfering RNA (issFRP2) so as to inhibit uterine scar formation, ionizable lipid, distearoyl phosphatidylcholine (DSPC), cholesterol and 1, 2-dimyristoyl-rac-glycerol-3-methoxy polyethylene glycol (DMG-PEG) are mixed and dissolved in ethanol according to a certain molar ratio, issFRP2 is dissolved in a citric acid buffer solution, and the issFRP2-targeted small interfering RNA (issFRP2) is added into the citric acid buffer solution so as to obtain a mixed solution; an ethanol phase and a water phase are mixed through a microfluid device, and the mixed solution is dialyzed in a PBS solution for two hours to prepare lipid nanoparticles. And then mixing the polycarbophil, the poloxamer and the lipid nanoparticles to prepare the composite hydrogel. The hydrogel can locally release sisFRP2 in the uterus, inhibit fibrosis, reduce collagen deposition and repair uterine scars. The hydrogel is good in biocompatibility and noninvasive, can realize slow release of the medicine, avoids repeated administration, has no obvious side effect on a maternal body and a fetus, and can also be used for other fibrosis-related diseases.

The invention relates to the technical field of biomedical materials and tissue engineering, and discloses sequential slow-release temperature-sensitive hydrogel and a preparation method and application thereof.The preparation method comprises the following steps that a blood sample is subjected to programmed centrifugation, and a gel layer of leukocyte-rich platelet-rich fibrin L-PRF and a gel layer of improved platelet-rich fibrin A-PRF are obtained respectively; and the gel layer is cut into pieces, pre-frozen, freeze-dried, ground and sieved, so that L-PRF freeze-dried powder and A-PRF freeze-dried powder are obtained respectively, and the methacrylic acid gelatin microspheres entrapped with the L-PRF freeze-dried powder are prepared. The microspheres and A-PRF freeze-dried powder are loaded into a temperature-sensitive hydrogel system composed of chitosan, polygalacturonic acid and sodium beta-glycerophosphate, so that the growth factors can be effectively entrapped in the hydrogel structure, and continuous release is realized; the system has good mechanical strength and structural stability, the retention time of the material in vivo is prolonged, and stable three-dimensional network support is provided.

The present invention belongs to the field of biomedicine, and specifically relates to a sodium pyruvate sustained-release nanoformulation based on pH response, and its preparation method and application. The preparation method of the nanoformulation: under the action of a catalyst, 2,3-dichlorobenzaldehyde, dopamine, and p-aminophenol are added to ethylene glycol dimethyl ether for substitution reaction to obtain compound 1; compound 1 and triethylamine are added to a phosphorus oxychloride solution, and stirred to react to obtain a compound with a phosphate group, an aldehyde group, and a catechol group; polylysine and aldehyde phenylboronic acid are reacted in a PBS buffer solution to obtain aldehyde phenylboronic acid-modified polylysine; sodium pyruvate is added to a solution of a compound with a phosphate group, an aldehyde group, and a catechol group to obtain a mixed solution, the mixed solution is homogenized, and a polylysine solution modified by aldehyde phenylboronic acid is added during the homogenization process, and a mixed solution is obtained after the homogenization is completed, and the mixed solution continues to be stirred and reacted, and the reaction solution is centrifuged, washed, and dried to obtain.

The application discloses a multifunctional injectable hydrogel and a preparation method and application thereof, and relates to the technical field of multifunctional hydrogel preparation and application. In the preparation, CMC-AGE and OD-SH are prepared respectively, and DSPE-se-se-PEG@AC NPs nanoparticles are prepared, then the multifunctional injectable hydrogel is prepared by forming a hydrogel through CMC-AGE and OD-SH and adding DSPE-se-se-PEG@AC NPs nanoparticles and / or beta nerve growth factor. The application also includes the multifunctional injectable hydrogel prepared by the above method and the application thereof. The application constructs an in-situ hydrogel delivery platform with good biocompatibility, is used for co-delivery of DSPE-se-se-PEG@AC NPs and NGF, is used in ischemic stroke treatment, and reshapes the pathological microenvironment of a cerebral infarction area, so that cerebral ischemic injury is reduced.

The invention discloses a buccal composition and a buccal product, the buccal composition comprises a temperature-sensitive gel system and a functional substance, the temperature-sensitive gel system comprises a temperature-sensitive gelling agent, when the temperature is higher than the critical gel temperature of the temperature-sensitive gelling agent, the temperature-sensitive gel system is converted into a gel state from a liquid state, and the critical gel temperature is 20-32 DEG C. The invention provides a buccal composition and a buccal product capable of improving the taste and experience of a user.

The invention discloses Fe (at) MoS2 hydrogel for sensitizing immunotherapy and a preparation method of the Fe (at) MoS2 hydrogel. The hydrogel comprises ferrous sulfate, molybdenum disulfide and a hyaluronic acid hydrogel matrix. The hydrogel can continuously release iron ions in a tumor slightly acidic environment, Fe is reduced into Fe by utilizing the catalytic action of MoS, and circular supply of Fe is realized, so that tumor cells are efficiently and enduringly induced to generate ferroptosis. More importantly, it is found that the Fe-coated MoShydrogel can specifically up-regulate expression of IL-36 gamma and CXCL2 in a tumor microenvironment for the first time, and by activating an IL36 gamma / CXCL2 / CXCR2 signal axis, mononuclear macrophages are recruited and remodeled, and the immunosuppression microenvironment is reversed. In-vivo experiments show that when the hydrogel is combined with an immune checkpoint inhibitor (such as an alphaPD-1 antibody), a remarkable synergistic anti-tumor effect can be generated, and the complete remission rate is greatly improved.

This invention discloses a method for enhancing the waterlogging tolerance of sesame seedlings using melatonin and its application. The method utilizes alginate oligosaccharides, boric acid, melatonin, calcium chloride, polyalkylene oxide-modified heptamethyltrisiloxane, and deionized water as raw materials. Through a stepped temperature control and multi-channel synchronous assembly process, a cross-linked network is constructed to physically encapsulate melatonin, effectively shielding its photosensitive area to slow down UV photolysis. This method features low surface tension, allowing easy penetration into microcracks and stomata on plant leaves. After a small amount of water evaporates, an in-situ sol-gel phase transition is triggered, forming a hydrogel microfilm that adheres to the leaf tissue, resisting natural rainfall washout and achieving slow-release of melatonin. This invention effectively solves the problems of easy loss and photolysis of conventional exogenous agents, and the components synergistically activate basic plant immune and antioxidant pathways, systematically enhancing the waterlogging tolerance of sesame seedlings.

The invention provides a gallwood extract gel and a preparation process thereof. The gallwood extract gel comprises the following raw materials in parts by weight: 1.8-5.8 parts of gallwood extract, 12.9-39.8 parts of aqueous gel matrix, 1.6-5.9 parts of penetration enhancer, 2.1-3.9 parts of nanocarriers and 1.2-1.9 parts of oligopeptides. The gallwood extract drug, the aqueous gel matrix, the penetration enhancer and the carrier nanomaterials are scientifically proportioned to synergistically exert the drug properties, and under the interaction between the stratum corneum and lipids of the skin, the diffusion resistance of the drug in the stratum corneum is reduced, the fluidity is enhanced, the onset time of the drug is shortened, the active ingredients of the drug in the gel are sustained-released within a certain period of time, and a higher permeability is achieved, so as to play a quick-acting role, and the highest permeability reaches 96.2% at 36 hours.

This invention discloses a bio-fermentation tank system for the harmless treatment of livestock and poultry manure and its usage method, belonging to the field of manure bio-fermentation treatment technology. The system includes an inclined and rotatable fermentation tank, an openable and closable cover, and supporting components. An installation plate with microbial filler holes is embedded inside the tank, with the holes pre-filled with adsorption substrate to fix the microbial community. A rotatable turbulence component is provided, which pushes the manure into the cutting chamber, where it is squeezed and segmented before flowing back to the main chamber, achieving cyclic treatment. The system is equipped with an independent gas control structure, supporting switching between aerobic and anaerobic fermentation modes. Through the synergistic effect of tank rotation and internal turbulence, thorough mixing of manure, mechanical cutting, and slow-release contact with the microbial community are achieved, significantly improving degradation efficiency and harmless treatment effect. This invention solves the problems of uneven mixing, low microbial activity, poor solid-liquid separation, and incomplete resource conversion in traditional processes, and is suitable for the efficient, harmless, and resource-based treatment of large-scale manure.

The application discloses a kind of all mixed sheep feed and preparation method thereof, belong to the technical field of feed.The preparation method includes: using constant temperature and humidity closed treatment cooperates with compound detoxification agent to cottonseed for detoxification treatment, preparation rumen steady state amino acid composite carrier and cellulose carrier load composite enzyme, then modified cottonseed, composite carrier, load composite enzyme are mixed with basic mixture, after conditioning, granulation obtains all mixed sheep feed.The application is through mild detoxification process, and cottonin removal and protein protection are considered, and rumen nutrient release synchronization is realized using bentonite slow-release carrier and microcrystalline cellulose immobilized composite enzyme, and essential oil and enzyme preparation are protected from processing heat inactivation.The obtained feed realizes the efficient full replacement of cottonseed to soybean meal, significantly improves the growth performance and feed conversion efficiency of Bayinbuluke black head sheep, and reduces the breeding cost.

The invention discloses a nerve suture line and a preparation method thereof. The preparation method comprises the following steps: step 1, mixing type I collagen powder, glycerol and glutaraldehyde according to a weight ratio of 95: (4-10): (1-5); 2, preheating and melting the mixture, then carrying out melt spinning, and carrying out cooling, stretching and surface treatment on spun tows to obtain a primary suture line product; step 3, mixing the PLGA solution and the dexamethasone solution according to a volume ratio of 9: (1-6), and carrying out high-speed shearing emulsification on the mixed solution; 4, coating, drying and curing, surface treatment and sterilization treatment are conducted on the primary suture line product through an impregnation method, and the nerve suture line is obtained. The suture line prepared by adopting the preparation method of the nerve suture line can realize sustained release of dexamethasone, and is beneficial to reducing inflammatory response at the early stage of nerve injury and promoting nerve repair; in addition, dexamethasone also has the effect of reducing foreign body reaction, rejection reaction of an organism after the suture line is implanted can be reduced, and the biocompatibility of the suture line is improved.

The invention belongs to the field of biomedical dressings, and discloses core-shell structure particles for promoting wound healing and application of the core-shell structure particles. The core-shell structure particles are obtained by taking a trehalose solution and a lucid ganoderma source chitosan solution as a core solution and a membrane casting solution respectively, carrying out air bath and coagulating bath in a pulse mode, and separating. The core-shell structure particles of some examples have relatively stable structures, can be stably dispersed in aqueous materials, and can be prepared into wound healing preparations in dosage forms, such as dressings, sprays, pastes and the like. The particle size of the core-shell structure particles is adjustable, so that the core-shell structure particles can go deep into the wound surface to realize better wound surface coverage and better promote wound surface healing. According to the core-shell structure particles of some examples, various repairing factors can be loaded in the shell, controlled release and slow release of the repairing factors can be achieved due to existence of the shell, and a better repairing effect is achieved.

The invention discloses a hydrogel for skin surface antibacterial and a preparation method thereof, belonging to the field of antibacterial gel. The present invention first modifies 6-amino-β-cyclodextrin to obtain acryloyl cyclodextrin (Ac-βCD); then adamantane is grafted onto hyaluronic acid to obtain adamantane-hyaluronic acid (Ad-HA); acrylyl cyclodextrin (Ac-βCD) is dispersed in water to obtain aqueous solution I; adamantane-hyaluronic acid (Ad-HA), an antibacterial agent, a moisturizer and a photoinitiator are dispersed in water to obtain aqueous solution II; aqueous solution I and aqueous solution II are mixed, left to stand, and ultraviolet irradiation is performed to obtain a hydrogel for skin surface antibacterial. The hydrogel for skin surface antibacterial in the present invention can be directly applied to the skin surface and kept moist for a long time, and its antibacterial rate for Gram-negative bacteria and Gram-positive bacteria reaches more than 99%, effectively inhibiting bacterial growth and protecting human health.

The invention belongs to the technical field of medicines, and particularly relates to a microneedle patch for disguising a macrophage cell membrane and a preparation method of the microneedle patch. Degradable high polymer material nano-particles camouflaged by the macrophage membrane are embedded in a microneedle array of the microneedle patch camouflaged by the macrophage membrane, and the degradable high polymer material nano-particles camouflaged by the macrophage membrane are wrapped with gambogic acid and oleic acid functionalized cerium dioxide nano-particles. Nanoparticles of the microneedle patch jointly load gambogic acid and oleic acid functionalized cerium dioxide, through microneedle transdermal drug delivery, active targeting of the drug to the liver is achieved by using natural inflammatory taxis of a macrophage membrane, the anti-inflammatory effect of gambogic acid and the anti-oxidation effect of cerium dioxide are synergistically exerted, polarization of macrophages is adjusted, and the anti-inflammatory effect of the drug on the liver is achieved. Therefore, the liver injury caused by the septic shock is treated.

The invention discloses a preparation method of an isolating and soothing non-woven fabric and a disposable hygienic product. The method comprises the following steps that the surface of an ES fiber net is pretreated, so that a nanoscale net-shaped pre-coating layer with positive charges is formed on the fiber surface; a dynamic slow-release composite mineralization layer is constructed outside the nanoscale net-shaped pre-coating layer; and constructing a gradient pore structure on the fiber net loaded with the mineralization layer. According to the invention, ES fiber is taken as a base material, and a dynamic slow-release composite system is adopted, so that anti-inflammatory factors are embedded into the biomimetic mineralization layer, and continuous release of components is realized; a gradient pore ventilation structure is constructed, and pore size distribution with dense top and sparse bottom is formed through a two-way stretching process, so that rapid infiltration of liquid is ensured, and good air permeability is maintained; and a self-crosslinking bonding interface is developed, so that the surface layer and the absorption core body are chemically bonded after being in contact with the liquid, and the isolating and relieving effects are achieved.

The present invention relates to the technical field of medical, dental or cosmetic preparations, and in particular to a regorafenib tablet and a preparation method thereof. The regorafenib tablet comprises the following raw materials in parts by weight: 40 to 160 parts of coated regorafenib, 50 to 300 parts of a diluent, 50 to 200 parts of a disintegrant, 20 to 400 parts of an adhesive, 1 to 8 parts of a lubricant, and 1 to 50 parts of a coating material. The present invention also provides a preparation method thereof. Compared with the prior art, the regorafenib tablet prepared by the present invention has the advantages of stable properties, high bioavailability, and a sustained release effect.

The invention belongs to the technical field of natural medicine extracts, and relates to a polygonatum sibiricum flower bud extract as well as a preparation method, a microcapsule preparation and application thereof. The polygonatum sibiricum flower bud extract contains one or more of rutin, apigenin-6-arabinose-8-glucoside, and apigenin-6, 8-diglucoside, and is characterized in that the polygonatum sibiricum flower bud extract contains one or more of rutin, apigenin-6-arabinose-8-glucoside and apigenin-6, 8-diglucoside. By utilizing the preparation method of the polygonatum sibiricum flower bud extract and the preparation method of the microcapsule preparation, the polygonatum sibiricum flower bud extract and the microcapsule preparation of the polygonatum sibiricum flower bud extract can be better prepared respectively; the prepared polygonatum sibiricum flower bud extract and the microcapsule preparation of the polygonatum sibiricum flower bud extract can better inhibit the activity of alpha-glucosidase in vivo and in vitro, and can be used for preventing or treating diabetes mellitus with better curative effect and smaller side effect.

The invention discloses a coating method of a colon targeted delivery drug. The method disclosed by the invention comprises the following steps: embedding a medicine coating by utilizing a mixture of starch acetate and gutta-percha; the medicine coating is obtained by coating a medicine with an inner coating material; and the inner packaging material is selected from beta-cyclodextrin, gamma-cyclodextrin, hydroxypropyl-beta-cyclodextrin, chitosan or a chitosan derivative. The release rate of the embedded medicine prepared by the method in gastric juice does not exceed 10%, and the release rate of the embedded medicine in intestinal juice exceeds 30%. Targeted delivery of the medicine in the colon is effectively achieved, toxicity of the medicine to cells is reduced, and excellent biocompatibility is shown.