421results about How to "Achieve sustained release" patented technology

A preparation method of vitamin A and vitamin E nano-sphere/microsphere double-embedding system belongs to the technical field of biological active substance control release microencapsulation. In the present invention, food grade vitamin A is nano-sphere core material and monoglyceride or beeswax is nano-sphere wall material to be made into nano-sphere suspension which is used as microsphere core material together with the vitamin E; ocentyl succinate esterified starch containing tween-80 is used as microsphere wall material; the nano-sphere/microsphere double-embedding system is manufactured by a thermal homogenization-spray drying method. The encapsulation rate towards the vitamin A of vitamin A nano-sphere manufactured by the present invention can reach to 82 percent to 94 percent, and the particle size of the nano-sphere is 200nm to 370nm. The encapsulation rate towards the vitamin A of the double-embedding system is 86 percent to 91 percent and the encapsulation rate towards the vitamin E is 89 percent to 93 percent. The double-embedding system can embed the vitamin A and the vitamin E synchronously and has the effect of releasing step be step, so as to avoid the mutual interference of active components, improve the biological utilization rate and can be added into various foods as vitamin intensifier and extender.

The invention provides a low-GI meal replacement rod for diabetes patients and a preparation method and applications thereof. The low-GI meal replacement rod is mainly prepared from following raw materials: dietary fibers, proteins, sugar alcohols, cereal grains, oil, and optional condiments; wherein dietary fibers comprise water soluble dietary fibers and insoluble dietary fibers. The main raw materials are all low-GI materials, at the same time, soluble and insoluble dietary fibers are added, through scientific blending, the meal replacement rod has a characteristic of low GI (glycemic index), and moreover, raw materials that are rich in dietary fibers such as chia seeds, oatmeal, quinoa, konjak, and the like, are added to effectively reduce the increasing of GI after meals. The low-GI raw material and raw materials rich in dietary fibers cooperate with each other, the satiety is enhanced, the hungry feeling is reduced, and the blood glucose fluctuation is reduced.

The invention provides an anastomat for gastrointestinal tract anastomosis surgery and a production method thereof. The anastomat comprises an anastomosis nail and a base and is divided into two types, namely a combined type and an independent type. The anastomat is composed of degradable materials and medical barium sulfate and can be finally disintegrated to be powder to be removed from the body after being used up. An envelope is formed on the outer surface of the anastomat through polyacrylic resin and contains medicines such as sulfonamides and quinolones antisepsis and anti-inflammation medicines and adrenobazonum, dicynone and other hemostasis medicines, and the envelope can selectively perform medicine slow release and controlled release according to different pH physiological environments of gastrointestinal tracts.

The invention provides a special slow release fertilizer for sugarcane. The special slow release fertilizer sequentially comprises a first fertilizer layer, a first film coating layer, a second fertilizer layer, a second film coating layer, a third fertilizer layer and a third film coating layer at a weight part ratio of (4-6) to (1-2) to (6-8) to 1 to (10-12) to (2-3) from inside to outside, wherein the first fertilizer layer is a fermented product of animal manure, marine product leftovers and a microorganism fermenting agent; the first film coating layer is a mixture of bentonite and acrylic resin; the second fertilizer layer is a fermented product of sugar filtering mud, molasses, saw dust, straws, traditional Chinese medicine liquid, yeast waste liquid and a fermentation bacterium agent; the second film coating layer is a mixture of zeolite and attapulgite; the third fertilizer layer is a mixture of a nitrogenous fertilizer, a phosphatic fertilizer, a potash fertilizer and traditional Chinese medicine residues; the third film coating layer is beta-cyclodextrin. The fertilizer is enriched with nitrogen, phosphorus, potassium and microelements; fermentation products and traditional Chinese medicine extracts are added into the fertilizer, and the continuous absorption and utilization on nutrition by the sugarcane are increased so that the releasing time of the fertilizer in soil is prolonged.

The invention discloses cleaning water-based paint with a bionic self-lubricating effect, and a preparation method thereof. By utilizing the characteristic that the surface is self-lubricated through a common nepenthes imitating effect, and adopting a mode of loading silicone oil on aerogel, a silicone oil lubricating fluid with the lubricating effect is sealed into a water-based resin paint base material; by combining adsorption of an aerogel porous structure and transfer behaviors, on a water-based resin surface, of silicone oil, the controlled release effect, on the surface of the water-based paint base material, of the silicone oil lubricating oil is achieved, and long-time self-lubricating cleaning effect is achieved. According to the preparation method, a super-hydrophobic rough surface is not needed to be constructed; the prepared paint has self-cleaning effect, good stability, environmental protection and no pollution; the preparation method is simple, is innovative, is high in implementation, and is more beneficial to industrial application.

The invention discloses a heavy metal passivator for reducing the bio-availability of cadmium in soil. The heavy metal passivator is prepared by mixing the following components in percentage by weight: 70 to 90 percent of biochar and 10 to 30 percent of modified sodium alginate. The heavy metal passivator disclosed by the invention not only has a function of passivating the heavy metal in the soil in situ, but also is capable of improving the soil structure and increasing the soil porosity, the pH (Potential of Hydrogen) of the soil is increased to a larger extent, and the function of repairing acidified soil is also obtained.

The invention relates to a knitted multilayered-structure nanofiber yarn tendon scaffold as well as preparation and application thereof. Yarn is of a multilayered core spun structure. The preparationcomprises steps as follows: core layer yarn penetrates through a hollow rotating funnel to serve as a receiving device, positive and negative high-voltage power sources are applied to double needles on the two sides respectively, electrospun nanofibers are twisted to the core layer yarn, and double-layer continuous nanofiber yarn is prepared; the double-layer nanofiber yarn is taken as a core layer, electrospun natural polymer nanofibers are arranged on the outer layer, and three layers of nanofiber yarn are prepared; finally, the 3D knitted scaffold is prepared from the different layers of nanofiber yarn with a knitting technology and is used for tendon repair. The knitted multilayered-structure nanofiber yarn scaffold has the characteristics that a function of enhancing mechanical properties of regenerated tissue for a long time is realized, biocompatibility is good and repair and normal function recovery of tendon injury are facilitated.

The invention provides a hemostatic sponge/drug-loaded fiber mat/hemostatic sponge compound and a preparation method thereof, and belongs to the technical field of polymeric medical materials. The compound has a three-layer sandwich structure, and comprises two hemostatic sponges and a drug-loaded fiber mat arranged between the two hemostatic sponges. The invention also provides the preparation method of the hemostatic sponge/drug-loaded fiber mat/ hemostatic sponge compound. The drug-loaded fiber mat is completely wrapped with the hemostatic sponges, the three layers are structurally closely connected and have no gaps, the hemostatic sponges have an obvious three-dimensional network structure, and apertures are connected, so the hemostasis function and the postoperative recurrence prevention function are realized.

The invention discloses use of supported nano zinc oxide as an anti-diarrhea agent for weaned pigs and a using method. According to the use of the supported nano zinc oxide as the anti-diarrhea agent for the weaned pigs, the supported nano zinc oxide is a composite material for supporting nano zinc oxide by using kaolin or montmorillonite or attapulgite or sepiolite or zeolite as a supporter. The zinc oxide accounts for 10 to 50 weight percent of the composite material for supporting the nano zinc oxide. The using method of the supported nano zinc oxide serving as the anti-diarrhea agent for the weaned pigs comprises that 160 to 800 mg/kg of supported nano zinc oxide based on zinc is added into a weaned pig feed. The supported nano zinc oxide can remarkably reduce the diarrhea rate of the weaned pigs, improve the daily gain, improve the form of the intestinal mucous membrane and protect the intestinal mucous membrane barrier; the fur of the pigs is red and bright; the toxic or side effect of high-zinc daily ration on the pigs is avoided; and the effect of the supported nano zinc oxide exceeds that of high-dose common zinc oxide, the consumption of the zinc oxide is greatly reduced, and zinc excretion and environmental pollution are reduced.

The invention provides a repairing and soothing skin care product containing a postbiotic component and a preparation method thereof. The repairing and soothing skin care product comprises the following components in percentage by mass: 1-5% of the postbiotic component, 1-8% of grease, 3-5% of a skin conditioner, 9-15% of a humectant, 0.5-8% of a surfactant, 0.6-1.2% of a thickening agent and the balance being deionized water. The postbiotic component comprises an antibacterial substance and an active metabolite, has the effects of reconstructing skin cells, improving elastin and updating metabolism of a corium layer, and has an effect of promoting proliferation of cuticle cells, and the prepared skin care product can enhance skin elasticity and has obvious skin soothing and repairing effects. According to the invention, the postbiotic component is a mixed solution obtained by fermenting a variety of strains such as lactobacillus plantarum, lactobacillus casei, bifidobacterium lactis, bifidobacterium animalis and lactobacillus rhamnosus; compared with a postbiotic component obtained by single strain fermentation, the effect of eliminating wrinkles and enhancing skin elasticity is better, and the multi-dimensional skin problem can be solved.

The invention provides a hydrogel dressing and a preparation method thereof. The dressing is prepared from a sea-buckthorn extract, a Chinese atractylode rhizome extract, hyaluronic acid, polylysin, polyhydroxyethyl methacrylate, carrageenan, 2-hydroxyethyl methacrylate, vitamin C, polyvinyl alcohol, calcium chloride, borax, ammonium dihydrogen phosphate, glycerinum, mannose and deionized water. The preparation method comprises the following steps: firstly preparing the sea-buckthorn extract and the Chinese atractylode rhizome extract, respectively, adding such components as hyaluronic acid, polylysin, polyhydroxyethyl methacrylate, carrageenan, 2-hydroxyethyl methacrylate and ammonium dihydrogen phosphate to 1/2 parts by weight of ionized water to obtain a mixed liquid I, next, adding such components as vitamin C, polyvinyl alcohol, calcium chloride, borax, glycerinum and mannose to the rest parts by weight of deionized water to obtain a mixed liquid II, and finally, mixing the sea-buckthorn extract, the Chinese atractylode rhizome extract, the mixed liquid I and the mixed liquid II, namely performing a thermal reaction, thereby obtaining the hydrogel dressing. The hydrogel dressing is capable of promoting the healing of a wound, and lasting in antibacterial effect and low in production cost.

The invention belongs to the field of preparation of targeted therapeutic microspheres of slow release formulation and in particular relates to a preparation method of taxol-loading polylactic acid-hydroxyacetic acid (PLGA) microspheres. The preparation method comprises the following steps: dissolving a polylactic acid-hydroxyacetic acid copolymer in an organic solvent, and adding a taxol drug, wherein the polymer and the taxol drug are uniformly dissolved to obtain an organic phase; dropwise adding the organic phase into a fresh polyvinyl alcohol aqueous solution and curing and forming microspheres; and performing centrifugal separation on the cured drug-loading microspheres to obtain the uniformly dispersed taxol-loading polylactic acid-hydroxyacetic acid (PLGA) microspheres. The taxol-loading targeted therapeutic PLGA microspheres prepared by the preparation method have an ideal drug loading ratio and encapsulation efficiency while guaranteeing the drug stability of taxol, can reach an effect of slow release, maintain the optimum drug concentration in vivo, prolong the action time of the drug and reduce the side effects brought by burst release of the drug, and have important theoretical value and actual application prospect.

The invention belongs to the field of biological medicines, and relates to application of nanoparticles, in particular to application of the nanoparticles as tumor microenvironment responsive drugs orimaging agents. The nanoparticle comprises a chelate shell formed by tannic acid and ferric ions, and chemotherapeutic drugs are entrapped in the chelate shell. In a tumor microenvironment, the nanoparticle can slowly release a chemotherapeutic drug entrapped in the nanoparticle and slowly release iron ions in the nanoparticle to enhance the nuclear magnetic resonance imaging effect. The technical scheme can be applied to medical practice of tumor imaging and tumor treatment.

The invention discloses a hydroxycamptothecin slow-release microsphere and a preparation method thereof, relates to an anti-tumor pharmaceutical preparation and provides a hydroxycamptothecin slow-release microsphere and a preparation method thereof with long time of continuous drug release, stable drug release and high drug utilization; a carrier is polylactic acid, anti-cancer drug of hydroxycamptothecin is packed in the carrier and a modifying layer of water soluble derivative of chitosan is arranged on the surface of the carrier; the hydroxycamptothecin and the polylactic acid are dissolved in an organic solvent so as to obtain solution A; polyvinyl alcohol solution with the concentration of 0.5 percent to 5 percent is prepared and sodium dodecyl sulfate is added to prepare mixed solution B with the concentration of 0.5 percent to 1 percent; the solution A is transferred into a disperse phase container of a film emulsifier, the mixed solution B is added into a continuous phase container, a water suction pump is started to lead the continuous phase to be cycled, a mobile phase is collected, a certain pressure is maintained and a pressure indicating value which is operated to the film emulsifier is reduced to 0kPa. The collected mobile phase is centrifugated, precipitation is collected and freeze-dried to obtain the unmodified drug-carrying microsphere and then the surface modifying of the microsphere is carried out.

The invention discloses a 3D printed Ti-PDA-PLGA microsphere bone defect repair stent. A 3D printed Ti stent is prepared by a laser sintering technology. Then, under certain conditions, dopamine is self-polymerized on the fiber surface of the 3D printed Ti stent to form a PDA coating, thereby preparing a 3D printed Ti-PDA stent; then PLGA microspheres carrying VEGF are prepared by a double emulsion-solvent evaporation method, and finally, BMP-2 and PLGA microspheres carrying VEGF are adsorbed and immobilized on the surface of the stent by an adsorption method, and finally the 3D printed Ti-PDA-PLGA microsphere bone defect repair stent is formed. The bone defect repair tissue engineering stent disclosed by the invention has the advantages of reliable mechanical property, high biological activity and safety, convenient implantation, small trauma and low cost, and can be used for the repair treatment of bone defect after bone traumas, bone tumors and bone infection.

The invention belongs to the technical field of wound dressings, in particular to a core-shell drug-loaded nano-fiber dressing and a preparation method thereof. The invention provides the core-shell drug-loaded nano-fiber dressing, and the core-shell drug-loaded nano-fiber dressing is obtained through coaxial electrostatic spinning, and sustained release of drugs can be realized; a core layer is constituted by mel and polyvinyl alcohol, and a shell layer is constituted by epsilon-polylysine and polycaprolactone; due to a core-shell structure, the mel as a natural active substance can be effectively protected, an influence of an organic solvent on the active substance is avoided; through wrapping with polycaprolactone as a hydrophobic shell layer, the phenomenon that glutaraldehyde as a toxic and organic solvent is crosslinked with the polyvinyl alcohol can be avoided; the epsilon-polylysine is loaded on the shell layer, so that a good bacteria inhibition effect is achieved; and moreover, the epsilon-polylysine also can enhance interaction between cells and materials, is beneficial for adhesion and proliferation of the cells, and is high in biocompatibility.

The present invention provides a polyolefin anti-fogging film master batch and a preparation method thereof. The polyolefin anti-fogging film master batch comprises, by weight of EVA, (1) 100% of EVA, (2) 0.5-2.5% of modified diatomite, (3) 3-7% of an anti-fogging agent, and (4) 1-3% of an EVA-g-BA graft. According to the present invention, after diatomite in the master batch is subjected to surface modification through a polyol amine compound, occurrence of particle agglomeration can be hindered so as to easily disperse diatomite in the anti-fogging agent and significantly enhance an absorption effect of diatomite on the dripping agent; with the EVA-g-BA graft, uniform dispersion of the polyol fatty acid ester anti-fogging agent in the polyethylene greenhouse film resin is promoted, wettability of the film surface is significantly improved, and the utilization rate of the dripping agent is significantly increased, such that the anti-fogging lasting period of the polyethylene greenhouse film can be prolonged to more than 65 months from about 3-10 months, damage of fog drops on the polyethylene greenhouse film at the middle-later stage of use is solved, and good market application prospects are provided.

The invention relates to a cholesteryl-carboxymethyl Curdlan nanometer particle and a preparing method. Cholesterol and carboxymethyl Curdlan are used as raw materials. The carboxyl of the carboxymethyl Curdlan is activated by 1-(3-dimethylaminopropyl)-3-ethylcarbodimide hydrochloride (EDC.HCl) and N-hydroxysuccinimide (NHS) firstly, and then reacts with the cholesterol to be synthesized. The mole proportion of the carboxymethyl Curdlan to the cholesterol to EDC to NHS is 1:(0.2-5):1:5. The prepared amphipathic polymer is beneficial to preparing nanometer particles and entrapping hydrophobic drugs. The invention has the advantages of simple preparing method, good reproducibility, high drug entrapping efficiency and easy industrial production, the drug entrapping particle can greatly prolong the action time of the drugs in human bodies, obviously change the distribution of the drugs in different organs, and achieve the functions on reducing toxic or side effect, prolong the circulation time in the human bodies and enhances the biological availability of the drugs.

The invention provides a mixed agrochemical granular agent capable of performing a controlled release of >=2 different kinds of agrochemical active ingredients having especially different solubility in water from each other and suitable for the treating method of seedling box of the rice at an individual eluting rate, and a method for producing the same. This controlled releasing mixed agrochemical granular agent is obtained by preparing a granulated material consisting of >=1 kind of agrochemical active ingredient having a high water solubility, an inorganic diluting carrier and a first thermoplastic material hardly soluble in water, setting the granulated material as an inner core and covering the surface of the core with a mixture of >=1 kind of agrochemical active ingredient different from the agrochemical active ingredients contained in the inner core and having a low water solubility, an inorganic diluting carrier and a second thermoplastic material hardly soluble in water to make an outer surface.

The invention relates to a corn compound fertilizer with slow-release and insect-resistant effects. The corn compound fertilizer is prepared from, by weight, 35-40 parts of urea, 10-15 parts of monopotassium phosphate, 12-15 parts of bentonite, 6-10 parts of charcoal, 0.5-1 part of boric acid, 1-1.5 parts of BSFA, 1.2-1.5 parts of manganese sulfate, 1-1.5 parts of ammonium molybdate, 12-15 parts of superphosphate, 5-7 parts of modified starch and 1.5-2 parts of extracts of traditional Chinese medicine. The corn compound fertilizer with the slow-release and insect-resistant effects can provide good nutrient elements for corn for meeting the requirement of corn for nutrient elements; meanwhile, plant raw materials are used based on the scientific proportion for preventing pests and diseases at the root, and the corn yield and quality are improved.