The application provides an ultrasonic response piezoelectric ionic hydrogel and application thereof, and the hydrogel is formed by cross-linking and solidification of a precursor solution under
ultraviolet irradiation; components of the precursor solution include a
photosensitive polymer, an ionic
polymer, a
photoinitiator and a
solvent; the
photosensitive polymer includes any one or a combination of at least two of polyether F127 diacrylate,
polyhydroxyethyl methacrylate,
polyethylene glycol dimethyl
acrylate, methacrylated
gelatin or methacrylated collagen; and the ionic
polymer includes any one or a combination of at least two of epsilon-
polylysine, polyethyleneimine
hydrochloride,
polyallylamine hydrochloride, polyquaternary
ammonium salt-10 or cationic
guar gum. The application uses ultrasonic
waves as an external remote driving
signal to non-invasively and painlessly activate the piezoelectric ionic effect of the hydrogel, generate detectable periodic
voltage and current signals in the hydrogel, and has excellent
treatment effect on
acne and
infected wound repair.