The invention discloses a
menthol ointment preparation process, which belongs to the technical field of ointment, and adopts
polyhydroxyethyl methacrylate and
quaternary ammonium salt modified
cyclodextrin as a carrier to wrap
menthol molecules to enhance the stability of the
menthol ointment. The added hydroxyethyl polymethylacrylate can be used as a
thickening agent and a stabilizing agent, so that the
physical stability of the ointment is improved, and meanwhile,
hydrogen-bond interaction is formed between the hydroxyethyl polymethylacrylate and menthol molecules;
quaternary ammonium salt has broad-spectrum
antibacterial activity and can effectively inhibit growth of
bacteria, fungi and some viruses, and
dispersity of
cyclodextrin is further improved through
mutual exclusion among cations. The modified structure can prevent menthol from volatilizing, reduce loss and prevent menthol from reacting with air and other substances, so that the stability of menthol is improved; the
release time can be controlled, so that the cool feeling of menthol is slowly and enduringly released in the use process, and the use effect is prolonged; the pungent smell is covered, so that the product is easier to accept.