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Composite artificial cornea and preparation method thereof

An artificial cornea and cornea technology, applied in the field of composite artificial cornea and its preparation, can solve the problems of lack of good compatibility, inflammation, corneal detachment, etc., and achieve the effects of simple structure, controllable parameters and uniform structure

Active Publication Date: 2021-05-25
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the skirt stent is the part directly in contact with the implant bed, which plays the role of fusion with human eye tissue cells, but most heterogeneous materials do not have good compatibility with human tissue, resulting in often Complications such as corneal detachment and inflammation may occur

Method used

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  • Composite artificial cornea and preparation method thereof
  • Composite artificial cornea and preparation method thereof
  • Composite artificial cornea and preparation method thereof

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Embodiment Construction

[0030] Embodiments of the present invention will be described in detail below. It should be emphasized that the following description is only exemplary and not intended to limit the scope of the invention and its application.

[0031] refer to Figure 1a to Figure 4 , in one embodiment, a composite artificial cornea 11, comprising a central optical lens column 12 made of polyhydroxyethyl methacrylate (PHEMA), a corneal skirt structure 14 made of acellular matrix hydrogel, And the middle interlayer grid support 13 that connects described central optics mirror column 12 and described corneal skirt structure 14, wherein the nerve cell support layer 15 and corneal stroma that adhesion growth cell is arranged in the described corneal skirt structure 14 The cell scaffold layer 16 is a two-layer scaffold.

[0032] In a preferred embodiment, the interlayer grid support 13 is printed by electrostatic direct writing, for example, by fusion printing by electrostatic direct writing biop...

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Abstract

The invention discloses a composite artificial cornea and a preparation method thereof. The composite artificial cornea comprises a central optical lens column made of polyhydroxyethyl methacrylate (PHEMA) and a corneal skirt structure made of acellular matrix hydrogel , and an intermediate sandwich grid support connecting the central optical mirror column and the corneal skirt structure, wherein the corneal skirt structure is provided with a nerve cell support layer and a corneal stromal cell support layer with cells adhered thereto. The composite artificial cornea is simple in structure, good in biocompatibility, easy to process, can well simulate the environment of the cornea in the body, and is favorable for transplantation.

Description

technical field [0001] The invention relates to a composite artificial cornea and a preparation method thereof. Background technique [0002] Corneal disease is the second leading cause of blindness after cataracts. Corneal clouding is one of the leading causes of bilateral blindness, affecting 7 million people worldwide. Of these, 2.85 million had reduced or no sensation due to corneal nerve dysfunction or degeneration. Corneal transplantation is the only way to restore sight to blind patients. However, traditional corneal transplantation has two major disadvantages. One is that the source of corneal donors is difficult, and the other is that the success rate of the operation is extremely low for corneal recipients with many new blood vessels. , such as corneas with severe chemical and thermal burns, corneas with multiple corneal transplant failures, corneas with severe dry eye, petechiae, etc. The emergence of artificial corneas can solve these two problems, that is, the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/14A61L27/16A61L27/18A61L27/36A61L27/38A61L27/50
CPCA61F2/142A61F2240/004A61L27/16A61L27/18A61L27/3633A61L27/3804A61L27/383A61L27/3891A61L27/50A61L2430/16C08L33/14C08L67/04
Inventor 王晓然王柏文杨习锋曾晨光
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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