Chemical compounds that are derivatives of 2H[1]-benzothiepino[5,4-c]
pyrazole, 2H[1]-benzoxepino[5,4-c]
pyrazole, 1-benzothiopyrano[4,3-c]
pyrazole, 1-benzopyrano[4,3-c]pyrazole, 4,5-dihydro-2h-furano[2,3-g]
indazole and 4,5-dihydro-2h-thieno[2,3-g]
indazole derivatives 2H[1]-benzothiepino[5,4-c]pyrazole, [1]-benzothiopyrano[4,3-c]pyrazole, 4,5-dihydro-2H-furano[2,3-g]
indazole and 4,5-dihydro-2H-thieno[2,3-g]indazole derivatives are inhibitors of
protein kinase activity. Several of the
protein kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic and / or edematous processes. Thus, these chemical compounds can ameliorate
disease states where
angiogenesis,
edema or endothelial
cell hyperproliferation or hyperpermeability is a factor. Like
cancer, artritis, atherosclerosis,
psoriasis,
hemangioma, myocardial
angiogenesis, coronary and cerebral collaterals, ischemic limb
angiogenesis,
corneal disease, rubeosis,
neovascular glaucoma,
macular degeneration,
wound healing,
peptic ulcer Helicobacter related diseases, fractures,
diabetic retinopathy, and cat scratch fever.