22 results about "Corneal disease" patented technology

A corneal elastic modulus measurement device and method based on magnetic nanoparticle excitation, including a soft magnetic nanoparticle contact lens, an electromagnetic excitation module, an OCT module, and a data processing module. The soft contact lens is wrapped with a sealing film and attached to the corneal surface, and generates a mechanical response under the controllable magnetic field generated by the electromagnetic coil; the OCT module synchronously captures dynamic deformation images before and after excitation, and its optical path is coaxially adapted with the annular electromagnetic structure to ensure synchronization of imaging and excitation. The data processing module extracts displacement information through multi-stage signal processing, combines the magnetic field force and the correction coefficient to compensate for the influence of corneal geometric parameters, and generates a high-resolution two-dimensional elastic modulus map. The system realizes real-time regional measurement of corneal mechanical properties with micron-level resolution, avoids the inadaptability of traditional technology with millimeter-level deformation, significantly improves the detection accuracy, safety and comfort, and is suitable for precise diagnosis and treatment evaluation of clinical corneal diseases.

The application discloses a corneal disease image detection and classification method and device based on local and global information, and the method comprises the following steps: segmenting an image to obtain a superpixel lesion area set; extracting local features and global features; obtaining superpixel lesion area feature representation combined with local and global information; performing classification training by using global main features combined with local features, and making a prediction on a corneal disease slit lamp image; performing unsupervised clustering and category representation on the superpixel lesion area, and visually displaying abnormal lesion areas in the corneal disease slit lamp image. The corneal disease image detection and classification method and device based on local and global information can effectively extract global features and lesion area local features of the slit lamp image, perform feature fusion on the abnormal areas, realize image classification and abnormal area display.

The invention discloses a corneal elastic modulus measuring device and method based on magnetic nanoparticle excitation. The corneal elastic modulus measuring device comprises a soft magnetic nanoparticle contact lens, an electromagnetic excitation module, an OCT module and a data processing module. The soft contact lens is attached to the cornea surface by wrapping magnetic nanoparticles with the sealing film, and generates mechanical response under a controllable magnetic field generated by the electromagnetic coil; the OCT module synchronously captures dynamic deformation images before and after excitation, and an optical path of the OCT module is coaxially matched with the annular electromagnetic structure to guarantee synchronization of imaging and excitation. And the data processing module extracts displacement information through multi-stage signal processing, compensates the influence of cornea geometric parameters in combination with a magnetic field acting force and a correction coefficient, and generates a high-resolution two-dimensional elastic modulus map. According to the system, real-time regionalization measurement of corneal mechanical characteristics is achieved with micron-level resolution, discomfort of millimeter-level deformation in the prior art is avoided, detection precision, safety and comfort are remarkably improved, and the system is suitable for precise diagnosis and treatment evaluation of clinical corneal diseases.

The invention discloses a functional decellularized porcine cornea, a decellularized porcine cornea composite scaffold containing layered slow-release bioactive molecules and a preparation method of the functional decellularized porcine cornea composite scaffold. The preparation method of the functionalized decellularized pig cornea comprises the following steps: (1) pretreating raw materials; (2) carrying out decellularization treatment; (3) carrying out functionalization treatment on the decellularized porcine cornea and the like. Researches show that the functionalized decellularized porcine cornea prepared by the method disclosed by the invention can well load bioactive molecules. In addition, the functionalized decellularized porcine cornea prepared by the method disclosed by the invention also has better mechanical properties. Furthermore, based on the functionalized decellularized porcine cornea, a layered sustained-release design and a 3D printing customization technology are adopted, the cornea scaffold with anti-inflammatory, regeneration promotion and neural restoration functions is constructed, breakthrough is achieved in the aspects of immune compatibility, mechanical properties and curative effect controllability, and an innovative solution is provided for cornea disease treatment.

The application discloses a line confocal OCT corneal imaging device and method integrated with a liquid lens automatic focusing, a light source module outputs light, the light passes through a line illumination generation module along an optical axis, enters a first beam splitter to form two light beams, and the two light beams enter a sample arm module to be incident to a cornea to form a reflection and scattering light beam carrying corneal information; and enter a reference arm module, pass through a second reflector to form a reference light beam; the reflection and scattering light beam and the reference light beam return to the first beam splitter along the optical axis to interfere to generate a corneal low-coherence interference signal, and sequentially enter an imaging expansion module and a spectrometer module along the optical axis to image; a computer centrally controls a first detector in the spectrometer module, an electrically-controlled displacement table in the reference arm module and a second detector in a liquid lens module; the liquid lens module is optically coupled to the sample arm module through a dichroic mirror to realize real-time measurement of an axial eye movement. The application provides a safer and more reliable inspection tool for early diagnosis and precise evaluation of corneal diseases.

The present invention relates to a composition for inhibiting angiogenesis containing yohimbine, and more specifically, to a pharmaceutical preparation and a functional food containing a composition capable of exhibiting preventive, improving, and therapeutic effects on angiogenesis-related diseases such as hemangioma, vascular adhesion, neovascular glaucoma, diabetic retinopathy, macular degeneration, corneal disease caused by neovascularization, or telangiectasia by containing yohimbine capable of inhibiting PDGF-induced vascular smooth muscle cell proliferation and migration through the factor FOXO3a.

The invention discloses a method for extracting radiomics characteristics of a cornea profile map, which comprises the following steps of: extracting a standardized region of interest (ROI) from the cornea profile map through image alignment, vertex positioning and self-adaptive cutting; performing standard radiomics feature extraction on the ROI image in parallel and extracting four types of self-defined features of multi-scale Gabor texture, HOG form, FFT frequency domain and fractal dimension optimized for the cornea structure to generate a high-dimensional feature vector; based on a machine learning strategy, an optimal feature subset is screened out through univariate pre-screening and recursive feature elimination cross validation (RFECV) in sequence, and importance sorting and diagnosis validity verification are carried out. According to the method, the problems of feature hiding and insufficient sensitivity of traditional macroscopic parameters in early diagnosis of the cornea conus are solved, mining of high-dimensional microscopic features from a conventional image is realized, and an effective auxiliary means is provided for objective and accurate diagnosis of corneal diseases, especially early cornea conus.

Current treatments for corneal disorders, also called keratopathies, depend on the stage of the keratopathy. For mild keratopathies, supportive treatments such as saline eyedrops may be sufficient to ameliorate symptoms. The present disclosure provides methods of treating corneal disorders with modulators of the WNT signaling pathway. More particularly, provided are treatments for cornea epithelial and / or endothelial injuries, defects, deficiencies, and dystrophies. Further provided are methods of dosing and pharmaceutical compositions for the treatment of corneal disorders.

The present invention relates to the treatment of corneal endothelial cells in corneal disease and / or dysfunction. Further, the present invention relates to a method of preparing corneal endothelial cells in vitro.

This invention relates to the field of intelligent medical image analysis technology, and discloses an intelligent classification method and system for corneal diseases based on confocal microscopy images. The method includes: preprocessing acquired confocal microscopy corneal images to obtain preprocessed corneal images and optical degradation parameters, and constructing a confocal corneal image dataset; constructing a deep neural network classification model, training the model using the confocal corneal image dataset to obtain a corneal disease classification model; inputting the desired confocal corneal image into the corneal disease classification model, outputting category prediction results and classification probabilities, and calculating the deviation of the feature vector of the desired confocal corneal image from the known category feature distribution manifold boundary to generate an outlier warning index; integrating the category prediction results, classification probabilities, and outlier warning index to generate a diagnostic report. This invention is adaptable to different image features and is particularly suitable for rapid screening and accurate diagnosis of corneal diseases in primary healthcare institutions.

This invention provides a corneal disease diagnosis system, method, and terminal based on anterior segment photography. The acquired anterior segment photograph is input into a corneal disease diagnosis model based on the fusion of learnable wavelet and Morse topological features to obtain diagnostic results. In the model, a frequency-aware modulation module performs learnable frequency domain decomposition and sub-band modulation on the input image to obtain frequency domain features and reliability scores; a topology-aware module globally models the long-range dependencies of the topological response at different scales and locations of the image to obtain topological embedding features and response scores. A confidence-aware topology and frequency fusion module uses a bidirectional cross-attention mechanism to align, modulate, and perceive consistency across modalities to obtain diagnostic results. This invention introduces Morse theory modeling into the topological structure branch to construct stable corneal morphological representations at multiple scales, and combines this with the Mamba model to efficiently model long-range dependencies; the frequency domain representation branch highlights discriminative frequency components, suppresses interference, and improves the stability of texture features. Furthermore, a fusion mechanism is designed to achieve adaptive correction and complementarity of heterogeneous features, and a reliability voting strategy is introduced to improve the robustness and credibility of the diagnostic results.

The invention discloses a treatment device for clinical cornea flushing, which comprises a treatment assembly, and the treatment assembly comprises a cover plate; the movable assembly comprises a liquid drainage hole, a liquid drainage pipe, a movable pipe, through holes, a supporting rod and a grip, the liquid drainage hole is formed in one side of the interior of the cover plate, the liquid drainage pipe is fixedly connected to the interior of the liquid drainage hole, the movable pipe is slidably connected to the interior of the liquid drainage pipe, and the through holes are formed in the periphery of one end of the movable pipe; the supporting rod is fixedly connected to the center inside the movable pipe, and the grip is fixedly connected to the outer end of the supporting rod. The treatment assembly and the movable assembly are arranged, eye medicine is injected into the liquid storage tank and enters the cover plate through the liquid inlet pipe, the cornea in the cover plate can be treated continuously, the sufficient medicine concentration is guaranteed, the infectious cornea disease cure rate is increased, and the functions of continuous flushing and flushing liquid discharging are achieved.

The present disclosure provides a modified adeno-associated virus 1 (AAV1) comprising an AAV1 VP3 capsid protein, wherein the AAV1 VP3 capsid protein comprises one or more mutations at a position selected from the group consisting of: S507, and S587, relative to a wild-type AAV1 capsid protein sequence of SEQ ID NO: 65. The present disclosure also provides capsid proteins, nucleic acids, and compositions comprising said modified AAV1. The present disclosure also provides a method of treating a corneal disease to a subject, wherein the method comprises administering a therapeutically effective amount of the modified AAV1, or the composition of the disclosure to a subject, wherein the modified AAV1 comprises a payload for treating a corneal disease. Also provided by the present disclosure is a method of delivering a payload to a cornea of a subject, comprising administering the modified adeno-associated virus 1 (AAV1), or the composition of the disclosure, to the cornea of the subject.

The application discloses a PROTAC nanocomposite, a preparation method and application thereof in products for treating ophthalmic diseases, relates to the technical field of biological medicine, and the PROTAC nanocomposite comprises a lipid layer and a PROTAC chimera for targeted degradation of ACSL4 wrapped in the lipid layer; wherein the lipid layer comprises an ionizable cationic lipid, cholesterol, DOPE and DSPE-PEG2000; the mass ratio of the ionizable cationic lipid, cholesterol, DOPE, DSPE-PEG2000 and the PROTAC chimera for targeted degradation of ACSL4 is (1.5-2.5):(0.8-1.2):(0.3-0.7):(1.5-2.5):1, based on the mass of the PROTAC nanocomposite; and the PROTAC nanocomposite can be applied to products for treating ophthalmic diseases, in particular, refractory corneal diseases, such as relieving and treating corneal alkali burn.

This disclosure features clusterin (CLU) as a multifunctional biotherapeutic for promoting ocular nerve regeneration for various ocular conditions. This disclosure features methods of using CLU for treating a subject with an ocular disorder, condition, or disease (e.g., an ocular surface disease, corneal disease or retinal disease). The methods described herein can be used for the treatment of ocular inflammatory conditions involving barrier disruption and nerve loss due to its ability to protect and promote the regeneration of ocular nerves.

The application discloses a method for improving the mechanical property of fish scale-based biomembrane and application thereof, and relates to the field of medical materials in medicine and bioengineering. The fish scale-based biomembrane is soaked in a certain solution for 8-15 hours, and then is placed in a reaction kettle to react with new certain solution, the reaction temperature is 4-200 DEG C, the reaction pressure is 0.1-20 MPa, and the reaction time is 5-24 hours, and the fish scale-based biomembrane with improved mechanical property is obtained after the reaction. The fish scale-based biomembrane prepared by the method has good compliance, the biomechanical property is close to that of human cornea, the optical property is excellent, the biological activity is good, and the cytotoxicity is zero, so the fish scale-based biomembrane can be directly applied to clinical transplantation and treatment of various corneal diseases and has excellent application potential in the field of ophthalmic materials. The method has the advantages of simple operation, low toxicity, low production cost and suitability for industrial production.

This invention provides an E2LSH corneal disease classification method based on residual networks, comprising the following steps: S1, loading pre-trained weights and parameters into the convolutional layers of the new model; S2, removing the traditional fully connected layers in the original ResNet residual network and designing new fully connected modules to reduce the depth of the residual network while increasing the number of channels in the feature mapping; S3, introducing Dropout between convolutional layers to effectively prevent overfitting; S4, extracting the output features of the last set of residual blocks as feature descriptors. This invention makes the model more compact by removing unnecessary modules from the conventional ResNet architecture. It also employs variance calculation to construct a dynamic hash index, enabling the selection of appropriate bucket width parameters and dynamic adjustment of the bucket width, resulting in relatively uniform data distribution within each hash bucket and further improving model performance. The improved ResNet-v model maintains a high average recognition rate and recall rate, exhibiting high accuracy and strong robustness.

The present application relates to the technical field of tonometer, in particular to a real-time dynamic tonometer, comprising a signal acquisition module, a signal processing module, an algorithm model module and a display module, the signal acquisition module and the signal processing module are in wireless communication through Bluetooth, the display module is used for displaying real-time intraocular pressure signal data, and the signal acquisition module comprises a plurality of flexible patches.In the present application, the flexible patch is provided with a three-axis acceleration sensor and a surface electromyography sensor, the three-axis acceleration sensor and the surface electromyography sensor are used for detecting eyelid tremor signals, the signal processing module is used for processing the tremor signals, the algorithm model module is used for calculating the intraocular pressure value, the measurement can be realized without contacting the eye membrane, the discomfort during measurement can be reduced, the tonometer is not affected by the corneal biomechanical characteristics, is suitable for patients with corneal diseases, and the user can perform measurement by himself.

The present disclosure provides methods of treating corneal disorders with modulators of the WNT signalling pathway. More particularly, provided are treatments for cornea epithelial and / or endothelial injuries, defects, deficiencies, and dystrophies. Further provided are methods of dosing and pharmaceutical compositions for the treatment of corneal disorders.

The invention relates to the technical field of biomedical engineering and drug delivery systems, in particular to an ROS-responsive hydrogel eye drop preparation, a preparation method thereof and application of the ROS-responsive hydrogel eye drop preparation in treatment of corneal diseases. Aiming at the problems of short ocular surface residence time, low bioavailability and the like of an existing eye drop preparation, glycyrrhizic acid is added on the basis of polyvinyl alcohol to jointly serve as a skeleton of ROS response type hydrogel TPG, and the obtained hydrogel eye drops have injectability, shear thinning characteristic and thixotropy, are suitable for being used as eye drops and have good application prospects. The composition can effectively prolong the retention time of the ocular surface, and can regulate the keratitis immune microenvironment by inhibiting the amplification process of neutrophil inflammation related to HMGB1 (High Mobility Group Box 1).

The invention discloses a multifunctional microneedle patch with a pH response sequential drug release function and a preparation method and application thereof, the patch is of an inner-outer layer core-shell structure, the outer layer of a microneedle is made of a pH response type material, and an antibacterial peptide preparation with an instant and rapid sterilization effect is encapsulated in the outer layer of the microneedle; and the inner core layer uses photosensitive methacrylated hyaluronic acid and encapsulates the mesenchymal stem cell exosome rich in bioactive components. The intelligent microneedle system shows the treatment advantage of a sequential drug release function: in the initial stage, the antibacterial peptide component rapidly plays a pathogen removal role to form a therapeutic protective barrier; subsequent sustained release of the exosome is used for adjusting a local inflammation microenvironment and promoting repair of damaged cornea tissues. The preparation method is simple, high in universality and suitable for large-scale production, has good biocompatibility and has important economic and clinical application prospects in the field of corneal diseases.