Screening method for transparency of membranous heterogeneous biomaterials and acellular dermal matrix

A biomaterial and screening method technology, which is applied in the field of film-like heterogeneous biomaterial transparency screening method and high-transparency acellular dermal matrix, can solve the problems of no screening method, inhomogeneous transparency, and homogeneous acellular dermal matrix In order to achieve the effect of less instruments and experimental materials and easy operation

Active Publication Date: 2021-03-09
PEKING UNIV THIRD HOSPITAL
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Problems solved by technology

According to the technical solution of the present invention, the current problems of poor homogeneity between different layers of acellular dermal matrix, uneven transparency and no effective screening method can be solved.

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  • Screening method for transparency of membranous heterogeneous biomaterials and acellular dermal matrix
  • Screening method for transparency of membranous heterogeneous biomaterials and acellular dermal matrix
  • Screening method for transparency of membranous heterogeneous biomaterials and acellular dermal matrix

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Embodiment Construction

[0037] The technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Apparently, the described embodiments are some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention. The present invention will be described in further detail below through specific implementation examples and in conjunction with the accompanying drawings.

[0038] Such as figure 1 As shown, a method for screening the transparency of a film-like heterogeneous biomaterial, comprising the steps of:

[0039]1) Dehydration of sucrose: Use trephine to drill a circular membranous heterogeneous biological material with a diameter of 6mm, and apply 20% sucrose at 4°C for 24 hours for dehydration. The sucrose treatment...

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Abstract

The invention discloses a method for screening the transparency of a film-shaped heterogeneous biological material, which comprises the steps of dehydration of the biological material sucrose, OCT embedding, layer-by-layer frozen sectioning, and light transmittance measurement with a spectrophotometer. Also provided is a highly transparent decellularized dermal matrix obtained by the above method. Through the present invention, the acellular dermal matrix with the best transparency can be effectively screened out, which can be used for lamellar keratoplasty, and the surgeon can use the above-mentioned matrix to replace the existing lamellar corneal stroma during the operation. At the same time, it can also effectively solve the contradiction of the current shortage of donor corneas.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a method for screening the transparency of membranous heterogeneous biomaterials and a highly transparent acellular dermal matrix. Background technique [0002] The human cornea is a layer of transparent membrane-like structure in front of the human eye. It is an important component of the eye's refractive system, and its function mainly depends on its optical properties. At present, changes in the optical properties of the cornea due to various corneal diseases and injuries have become one of the most important causes of human blindness, ranking second only after cataracts. For irreversible corneal blindness, the most effective and recognized treatment method is allogeneic corneal transplantation. However, there is a serious shortage of corneal donors in my country every year. The lack of sources of corneal materials has become the most important factor limiting the promotio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/31A61L27/36A61L27/50
CPCA61L27/3633A61L27/50A61L2430/16G01N21/31
Inventor 李学民王岳鑫邱伟强刘子源
Owner PEKING UNIV THIRD HOSPITAL
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