304 results about "Dermis" patented technology

Systems and methods utilizing RF energy to treat a patient's skin (e.g., dermis and hypodermis) or other target tissue including at a depth below a tissue surface (e.g., skin surface, mucosal surfaces of the vagina or esophagus) are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which the deposition of RF energy can be selectively controlled to help ensure heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, vaginal laxity or rejuvenation treatment, urinary incontinence treatment, fecal incontinence treatment, all by way of non-limiting examples. In various aspects, the systems can comprise one or more sources of RF energy (e.g., a RF generator), a treatment applicator comprising one or more electrode arrays configured to be disposed in contact with a tissue surface, and a return electrode (e.g., a neutral pad) to the tissue surface.

The present invention features methods of manipulating subdermal fat in a treatment area. Such methods include inserting a needle (e.g., a micro-coring needle) through the dermis to the subdermal fat layer in order to excise a portion of tissue from the treatment area. These insertions result in a portion of the dermis and a portion of the subdermal fat to enter into the needle. Removal of the needle results in excision of the portion of dermis and subdermal fat that entered into the needle.

The invention provides a mobile terminal skin parameter inversion method based on spectral information, and the method comprises the following steps: constructing an optical model according to the characteristics of a skin layered structure and a spectral response mechanism of three skin parameters: melanin content, hemoglobin concentration and dermis thickness, and building a skin parameter and reflection spectrum database based on the model; based on the database, establishing a skin multi-parameter inversion MLP neural network structure adaptive to the collection characteristics of a mobile phone end sensor, and screening an optimal four-waveband channel through multi-waveband combination traversal; the mobile phone spectrum sensor is subjected to wave band optimization, data acquisition and skin parameter inversion. According to the method, through efficient decoupling of a nonlinear coupling relation among multiple skin parameters by waveband optimization and an MLP model, and targeted design of four optimal visible light narrow-band channels, synchronous quantitative detection of melanin, hemoglobin and dermis thickness is realized, core physiological parameters from epidermis to dermis superficial layer are covered, information coverage is comprehensive, and specificity is high.

An object of the present invention is to provide a formulation effective for activation of hair dermal papilla cells. Provided are a composition for activation of hair dermal papilla cells, a composition for hair regrowth promotion or hair growth, a composition for hair quality improvement, and a composition for FGF-2, FGF-7 or VEGF production promotion, containing a culture supernatant and / or extracellular vesicles of a microalga.

A topical neurocosmetic composition comprising a first component including one or more of bakuchiol, allantoin, squalane, or Morinda citrifolia extract; a second component including one or more of hyaluronic acid, vitamin E, Zanthoxylum alatum fruit extract, Coriandrum sativum seed oil, Vitex agnus-castus extract, Helianthus annuus sprout extract, niacinamide, resveratrol, or an ascorbyl ester; and a cosmetically acceptable oil-in-water vehicle configured to deliver both lipophilic and hydrophilic actives through the skin to dermal neurons. The composition improves measurable skin parameters such as hydration and elasticity and supports psychophysiological comfort. Methods of manufacture and use are also described

The present invention provides a composition for restoration of tissue including a biodegradable polymeric copolymer which is obtained by polymerizing a hydrophobic biodegradable polymer and a hydrophilic biodegradable polymer. The composition of the present invention has excellent tissue restoration effects because of high collagen production rate without occurrence of nodules even when injected directly into the dermis, unlike the conventional composition for restoration of tissue.

The present invention provides a composition for reducing or eliminating vascular occlusion caused by hyaluronic acid soft tissue dermal fillers. [Solution] This disclosure provides for compositions comprising hyaluronidase, apparatus for housing such compositions, and methods and uses of such compositions and apparatus for reducing or eliminating hyaluronic acid-induced blockages in one or more blood vessels supplying an individual's eye; methods and uses of such compositions and apparatus for reducing or inhibiting vascular occlusion of an individual's eye; and methods and uses of such compositions and apparatus for reducing or inhibiting hyaluronic acid-induced vision loss in an individual.

According to the application of the arcangelisia loureiri extract in preparing the burn and scald wound healing medicine, the arcangelisia loureiri crude extract is obtained through extraction and concentration with a decoction method, and wound healing can be promoted by reducing the area of a rat skin wound, shortening the healing time of the rat skin wound, reducing the hyperplasia speed of the skin corium layer and promoting healing of the wound; the effects of remarkably promoting wound healing of burns and scalds and reducing scars are achieved.

This utility model discloses a beauty device, relating to the field of medical aesthetics technology. The beauty device includes a shell assembly, an adsorption pump, a circuit assembly, and a first electrode pair. The shell assembly has an adsorption chamber, an air intake, and an action port. The first electrode pair includes a first positive electrode and a first negative electrode located at the action port, which are arranged opposite to each other and electrically connected to the circuit assembly. Both the first positive and first negative electrode include a main body segment and an inclined segment. The main body segment is located on the outer end face of the action port, and the inclined segment extends from the action port to the inner wall of the adsorption chamber. The adsorption pump adsorbs the dermis and subcutaneous tissue of the target treatment area into the adsorption chamber, placing it between the two opposing inclined segments. This utility model improves the structure of the beauty device, significantly increasing the effective depth of action, reaching the deep dermis and even subcutaneous tissue; the effective range of action is also significantly increased; and the effective depth and range of action are adjustable.

This invention discloses recombinant type III collagen, its preparation method, and its applications. The amino acid sequence of the recombinant type III collagen is shown in SEQ ID NO: 9. The recombinant type III collagen integrates the RGDV highly active motif and the EKEK hydrophilic stable domain with the core structure of type III collagen to achieve an integrated design of "high activity and long-lasting effect". The in vitro cell migration and collagen secretion effects are improved by more than 50% compared with wild type. Through anti-enzyme cleavage site modification and hydrophilic modification, the in vivo residence half-life is significantly prolonged to meet the long-term repair needs of the dermis.

The invention discloses a multi-scale artificial dermal scaffold and a preparation method thereof, and belongs to the technical field of tissue engineering and biomedical materials. The artificial dermal scaffold is of a three-dimensional porous structure formed by microfilaments of a first frame and a second frame, the microfilaments of the second frame are distributed in pores of the first frame, disordered microfilaments which do not affect the penetrability of the macropores are arranged in the macropores in the top surface of the first frame, and longitudinally aligned microfilaments are arranged in the micropores in the section of the first frame. Through the specific structure, the adhesion, proliferation and migration effects of cells can be remarkably improved, and rapid vascularization of artificial dermis is facilitated. In addition, the preparation process of the artificial dermal scaffold is simple and easy to operate, can be used for batch preparation, and has a good application prospect.

The application discloses a new application of a JAK inhibitor and a medicine for promoting skin stretch regeneration, and application of the JAK inhibitor in preparation of the medicine for promoting skin stretch regeneration; the medicine for promoting skin stretch regeneration comprises the following components: a JAK inhibitor and a carrier, wherein the carrier comprises sodium hyaluronate and propylene glycol; the application provides a new application of the JAK inhibitor, and the JAK inhibitor can promote skin stretch regeneration, in particular, can promote increase of hair follicle density, increase of epidermis thickness, increase of dermis thickness, reduction of fibrosis degree, reduction of immune infiltration degree and reduction of myofibroblast quantity after skin expansion.

The application relates to the field of biological products, in particular to application and application method of glutathione in medical devices or cosmetics, and a medical device / cosmetic containing glutathione, and provides application of glutathione in specific medical devices (such as products for facial superficial dermis injection, products for wound care) and various cosmetics, wherein the amount of glutathione is 0.1-3 wt%, the glutathione is used in combination with sodium hyaluronate at a mass ratio of (0.1-3):(0.6-3), and specific antioxidant components (such as vitamin C, vitamin E, etc.) and chelating agents can be further compounded to form a synergistically stable composite system. The application effectively improves the storage stability of glutathione in the product, and enables the glutathione to be adapted to various application scenes such as injection, wound care and skin care, thereby providing a reliable technical scheme for industrial application of glutathione in the fields of medical devices and cosmetics.

Methods and systems are disclosed for tattoo removal from a subject by exposing tattoo ink particles trapped within the dermis to electrical energy. The tattoo removal method and system can be used to remove the tattoo from the skin of the subject being treated. In addition, the method and system described allows for the extraction of the tattoo ink particles, which may have toxic properties, from the subject's body.

This invention provides a bilayer programmed release hydrogel dressing based on PD-168077. The hydrogel dressing is formed by photocrosslinking a lower fast-release layer and an upper slow-release layer. The fast-release layer is formed by photocrosslinking and curing a first pregel solution containing a first concentration of methacrylamide hyaluronic acid, methacrylamide collagen, a photoinitiator, and PD-168077. The slow-release layer is formed by photocrosslinking and curing a second pregel solution containing a second concentration of methacrylamide hyaluronic acid, methacrylamide collagen, a photoinitiator, and PD-168077. This invention also provides a method for preparing the dressing and its application. This invention constructs a biomimetic dermal triple network structure through a photopolymerization strategy of "single formulation, dual concentration, dual curing," achieving programmed release of PD-168077 with a fast-then-slow release. This synergistic effect of the drug, including anti-inflammatory, antioxidant, and angiogenesis-promoting properties, along with matrix bioactivity, effectively promotes the healing of chronic diabetic wounds.

It is an object of the present invention to effectively promote growth of granulation tissue at a dermal defect or a subcutaneous tissue defect caused by a severe burn. To achieve this object, burn treatment cells for use in treatment of burns are composed of placenta-derived cells of an animal and promote healing.

The present invention relates to a peptide having an activity of promoting hair growth or preventing or inhibiting hair loss. The peptide of the present invention has an activity of promoting proliferation of hair follicle dermal papilla cells (HFDPC), activating a cell proliferation-related signal protein in human dermal papilla cells, activating β-catenin, improving expression levels of factors downstream of β-catenin, down-regulating expression levels of hair-loss protein DKK-1, and increasing expression of keratins in hair outer root sheath cells (HORSC).

The application discloses a plant Lactobacillus plantarum CCFM1353, a metapolybiose prepared from the plant Lactobacillus plantarum CCFM1353 for preventing hair loss and promoting hair growth, and application of the metapolybiose in combination with transformed Chinese arborvitae leaves, and belongs to the technical fields of microorganisms and medicines. The plant Lactobacillus plantarum CCFM1353 and the metapolybiose and symbiotic preparation prepared from the plant Lactobacillus plantarum CCFM1353 can promote the expression of IGF-1, VEGF and TGF-beta 2 of hair follicle dermal papilla cells (HDPC), promote hair growth of mice, and promote the expression of VEGF, IGF-1, Wnt10b, Cyclin D1, Ki67 and Bcl2 in the skin of mice. The plant Lactobacillus plantarum CCFM1353 and the metapolybiose and symbiotic preparation prepared from the plant Lactobacillus plantarum CCFM1353 can be used for preparing products for preventing and / or treating hair loss, and have great application prospects.

The present invention relates to a peptide with the activity of promoting hair growth or preventing or inhibiting alopecia. The peptide of the present invention promotes the proliferation of human follicular dermal papilla cells (HFDPC), activates cell proliferation-related signaling proteins and beta-catenin in human dermal papilla cells, enhances the expression levels of beta-catenin downstream genes, down-regulates the expression levels of the hair loss protein DKK-1, increases the expression of keratin proteins in hair outer root sheath cells (HORSC) and up-regulates the expression of transcription factors involved in cell activation in germinal matrix cells (GMC).

The present invention relates to a microneedle structure and a composition thereof that can effectively deliver a drug locally or systemically within the body by penetrating the dermis layer through the transdermis without causing damage to the skin by including a biodegradable composition containing a drug and hyaluronidase.

This invention provides a method for obtaining ingredients from Dulong Paris polyphylla (… Paris dulongensis A method for preparing parisyunnanoside G (PFE55) in H. Li & Kurita and its application in cosmetics and pharmaceuticals. This research belongs to the field of cosmetics and pharmaceutical technology. PFE55 is used at extremely low concentrations (0.1... μ At a concentration of g / mL, it exhibits activity in promoting collagen secretion in adult dermal fibroblasts (HDFa) and is non-cytotoxic at this concentration, making it suitable for the preparation of anti-aging drugs or skincare products.

A topical nerve activation patch includes a flexible substrate, a dermal adherent bottom surface of the substrate including an adhesive and adapted to contact a user's dermis, a flexible top outer surface of the substrate, a plurality of electrodes positioned on the patch proximate the bottom surface and beneath the top outer surface and coupled to the flexible substrate, a power source, and electronic circuitry generating an output voltage applied to the electrodes. The electronic circuitry includes a controller, a voltage monitoring circuit coupled to the controller, a current monitoring circuit coupled to the controller, a switch coupled to the controller, and a two-stage boost circuit coupled to the switch and the power source configured to increase a switch voltage level to approximately half of a final output voltage before increasing to the final output voltage.

A universal biological prosthesis of acellular dermal matrix (ADM) intended for use in body reconstruction processes and method of manufacture. A universal biological prosthesis of acellular dermal matrix (ADM) intended for use in body reconstruction processes, comprising: a first layer of ADM of biological origin arranged inferiorly to delimit a cavity with a lower edge; a filling material disposed in the cavity surrounded by the first layer of ADM consisting of a ground ADM having the consistency of a fibrous paste; and a second layer of ADM of biological origin arranged on the upper part covering the filling material and whose upper edge rests peripherally on the lower edge of the first layer of ADM, thus defining a rim;where the first layer of ADM and the second layer of ADM are joined by an eyebrow overlap along the upper edge of the first layer of ADM with the lower edge of the peripheral rim using a biocompatible adhesive, or by absorbable suture; where the first layer of ADM, the second layer of ADM and the ADM filling material are not immunogenic; and where the ADM comprises collagen fibers, fibronectin, elastin, laminin, glycosaminoglycans and hyaluronic acid. Method for its manufacture.

Dermatological compositions comprising amphiphilic peptides, derivatives or salts thereof are provided. The compositions are particularly useful as dermal fillers and for inducing soft tissue repair and regeneration.

The invention belongs to the technical field of medical evaluation, and relates to a method for evaluating damage of air pollution to human skin health based on a PPO-LSTM fusion algorithm. The method comprises the following steps: acquiring multi-source data; preprocessing data, and constructing a multi-dimensional time sequence feature data set; establishing a PPO-LSTM fusion model, performing feature extraction and reinforcement learning optimization on the multi-dimensional time sequence features, and outputting skin health core indexes; performing prediction and quantitative evaluation on the functional states of the cuticle, the epidermal layer and the corium layer; generating a personalized nursing decision scheme for skin health maintenance; outputting corresponding early warning information and coping suggestions by judging the risk levels of the skin barrier function and the dermal metabolism function; and updating parameters of the skin health injury evaluation model. According to the method, multi-dimensional data are integrated in the same model at the same time, the evaluation dimension is more comprehensive, the accuracy of skin health injury evaluation is improved, and a complete closed loop from detection evaluation to nursing scheme generation and risk prompt is realized through decision making and early warning.

The application discloses a kind of photo-cured silk fibroin double-layer hydrogel and preparation method thereof, belong to medical dressing technical field.The double-layer hydrogel includes upper silk fibroin hydrogel, lower hyaluronic acid hydrogel.The application is covalently bridged by interface transition layer mussel myopic double mechanism through ultraviolet light excitation, realizes upper and lower covalent crosslinking, improves interlayer bonding strength.Two-step photo-curing process is used, and the whole process time is less than 70 seconds, and the preparation is simple, fast and easy to operate.The double-layer hydrogel can simulate the "epidermis-dermis" double-layer structure of skin, has good biocompatibility and moisturizing property, and effectively promotes wound repair.

The invention relates to the technical field of cosmetics, and particularly discloses a degradable microneedle temperature control type striae gravidarum repairing film patch and a preparation method thereof. Comprising four layers of structures which are sequentially compounded from outside to inside: a nanofiber substrate layer; a microneedle essence layer; a temperature control adjusting layer; and attaching a fixing layer. By constructing a four-layer collaborative system, the day and night temperature rhythm of the skin is converted into a trigger signal, and a temperature response-microneedle degradation-drug release linkage closed loop is achieved. The degradable microneedle can be utilized to break through a cutin barrier, repair components are accurately delivered to a corium layer, anti-inflammatory and collagen-promoting components can be released at night in an accelerated manner through a temperature control mechanism, and the mode is automatically switched to a slow-release stability maintaining mode in the daytime, so that accurate matching with a human physiological repair rhythm is achieved.

A system and method of tattooing skin comprising creating voids extending from a surface of the epidermis into the dermis; introducing a dye through the voids into the dermis; and fixing the dye in the dermis. There is provided a system of needleless tattooing comprising a sensor for sensing a location of the surface of a region of skin of a subject, a dermal penetration device for penetrating into the skin, a controller responsive to the sensor to control the dermal penetration device to penetrate into but not through the dermis in the region of skin of the subject.

This invention discloses a method for culturing skin organoids for large-scale production and the skin organoids used for large-scale production, belonging to the fields of tissue engineering and biomanufacturing technology. The method involves laying a dermal matrix layer composed of orthogonal double-network hydrogels embedding fibroblasts in a bioreactor containing multiple independently operable culture modules. After inoculating keratinocytes, negative pressure is used to drive a uniform descent of the culture medium level to achieve gas-liquid interface culture. The first network of the orthogonal double-network hydrogel is formed by photocrosslinking of methacrylamide recombinant collagen, and the second network is formed by Michael addition of thiolated polysaccharides and multi-arm polyethylene glycol maleimide. During the culture process, the barrier maturity is assessed in real time by online monitoring of transepithelial resistance, and the negative pressure is controlled accordingly. A single batch can produce 3000 cm³ of skin organoids. 2 The above-mentioned qualified skin organoids have a transepithelial resistance coefficient of variation of less than 10%.

The present invention relates to: a fish-derived acellular dermal matrix having improved tissue-to-tissue adhesion problems while ensuring biocompatibility by removing cellular components from fish-derived by-products; and a preparation method therefor.