The invention provides a medical device having a thermister for temperature measurement, irrigation/aspiration ports for fluid exchange and application of therapeutic modalities, a pressure manometer for pressure measurement, and an external system for control of temperature, pressure, and flow rate. When applied to the central nervous system (CNS), this device can be used in hypothermia or hyperthermia applications, the exchange of cerebral spinal fluid (CSF), the application of treatment modalities, and the insertion of a ventriculostomy or ventriculostomy-like unit. When applied to spinal cord applications, this device can provide temperature control and a method for application of treatment modalities by using a venting device placed in the space surrounding the spinal cord, a device with similar instrumentation to measure temperature and pressure. A device for ultrasound localization of the CNS device is described. A device for a fiber optic endoscope for visualization and localization is also described. Method of using the devices in treating patients suffering from cardiac arrest, circulatory arrest, exsanguination, head or neck trauma, strokes, tumors and other intracranial diseases are disclosed. In the case of hypothermia treatment of the brain, rapid cooling using principles of convection and conduction will be applied to the lateral ventricle and subarachnoid and/or subdural space simultaneously where the neurons are located in close proximity.