63 results about "Systole" patented technology

The invention discloses a TAVR postoperative blood flow parameter complementing method based on CT-MRI fusion, and belongs to the technical field of crossing of medical image processing and computational fluid mechanics. A CT valve frame registration technology is adopted, an invisible artificial valve leaflet three-dimensional structure is reconstructed through valve frame information in a CT image and is coupled with a dynamic heart model, a complete valve mechanical and functional simulation platform is constructed, the problem of an imaging blind area is solved, hemodynamic parameters of an inlet and an outlet of a postoperative area are further collected in combination with 4D Flow MRI, and the artificial valve leaflet three-dimensional structure is obtained. The blood flow conditions of the upstream and the downstream of the artificial valve area at each stage of contraction and relaxation of the TAVR postoperative part are comprehensively restored, the temporal-spatial resolution and the physical authenticity of the boundary condition in fluid-solid coupling simulation are greatly improved, and the more real passive response of the valve leaflet under the action of the blood flow is obtained; and a reliable basis is provided for quantitative and mechanical risk analysis of postoperative complications such as thrombosis, perivalvular leakage and valve leaflet fatigue.

This application relates to a fully automated method and apparatus for quantitative analysis of myocardial acoustic contrast imaging. The method includes: acquiring myocardial acoustic contrast imaging images; segmenting the acquired myocardial acoustic contrast imaging images to obtain myocardial segmentation images; calculating the cardiac chamber area based on the myocardial segmentation images; automatically extracting the myocardial segmentation results at the end of cardiac systole using the periodic changes in cardiac chamber area; using the extracted end-systolic segmentation results as a mask to extract the corresponding position of each image as a target region for registration, thereby generating a one-to-one correspondence of registered image sequences; fitting a function model based on the pixel values ​​of each point in the registered image sequence; and generating a parametric image based on the registered image sequence and the fitted function model. Therefore, this application can perform fully automated quantitative analysis of myocardial acoustic contrast imaging.

Apparatus and methods for repairing a cardiac valve, e.g., a tricuspid valve, are provided. The apparatus may include a prosthetic device coupled to an elongated support coupled to a stent configured to be implanted within a vessel, e.g., the superior vena cava, to suspend and maintain the prosthetic device within the cardiac valve. The support may include a proximal, delivery portion detachably coupled, in a delivery state, to a distal, implantable portion coupled to the prosthetic device. The prosthetic device may be formed of biocompatible material coupled to a frame, and may have prosthetic leaflets that allows blood to flow therethrough in one direction during diastole, but prevents blood regurgitation during systole. The stent further may include features configured to resist migration of the stent within the vessel, as well as to prevent in-folding of the stent during deployment.

This invention discloses a non-contact electrocardiogram (ECG) measurement method using millimeter-wave radar. First, the original chest wall displacement signal acquired by the millimeter-wave radar is preprocessed to obtain a displacement feature branch input. Then, the original displacement signal undergoes cardiac sound band enhancement, wavelet denoising, and envelope extraction to obtain radar cardiac sound features. A hidden semi-Markov model is constructed to model the states of the first heart sound, systole, second heart sound, and diastole in the cardiac cycle, obtaining the posterior probability of the state at each time point. Next, the displacement features, radar cardiac sound features, and state probability features are input into a multi-branch convolutional fusion network, combined with a bidirectional long short-term memory network to achieve temporal correlation modeling, finally outputting the reconstructed human ECG result. This invention achieves non-contact ECG measurement without skin electrode contact by fusing the original mechanical displacement of the chest wall, the mechanical vibration features of the heart sounds, and the explicit state prior information of the cardiac cycle.

This invention provides an apparatus for repairing heart valves and a method for implanting anchors and repairing heart valves. The apparatus includes: a body; a component attached to the body at a first end and having a plurality of positioning cords extending laterally across a space between the component and away from a second end of the component opposite to the first end; a tube suspended from the plurality of positioning cords; and an adjustment cord extending through the tube. The method includes: implanting at least one annular anchor into the mitral valve annulus of a heart valve; implanting papillary anchors through each papillary muscle of the heart; delivering and positioning the apparatus for repairing the heart valve within the heart valve using at least one annular anchor and papillary anchors; and adjusting the apparatus to adjust the degree of atrial displacement of the mitral valve leaflets during ventricular systole.

A method for operating a blood pressure measuring apparatus includes the steps of: applying a measuring apparatus, containing a pressure unit and / or a pressure measuring unit, to a measurement point on the body; initialising the measuring apparatus by carrying out a reference measurement and / or by carrying out defined position changes to the measurement point and determining person-specific initialisation parameters; storing the person-specific initialisation parameters in a memory and control unit; carrying out at least one blood pressure measurement by applying a counter pressure to the pressure unit in a sub-systolic low-pressure range; maintaining the applied counter pressure within a plateau phase having a predefined duration and recording blood pressure time curve data during the predefined duration; converting the recorded blood pressure time curve data over the initialisation parameters into arterial blood pressure data over time.

A blood pressure monitoring device includes a wristband, a housing, and a display. The strap portion is adapted to secure the device to the wrist without obstructing blood flow. At least one sensor modality is disposed within the housing for obtaining sensor data from an artery in the wrist. In a preferred embodiment, a photoplethysmography sensor is incorporated in a housing to generate PPG waveform data. A processor within the housing is operable to calculate an average arterial pressure based on the extracted and calculated characteristics of the sensor data, and optionally to calculate diastolic and systolic blood pressures. Related methods and systems are also described.

Vascular blood flow modulation is disclosed using metallic compliance-enhancement devices that contain a sealed volume of fluid. The device includes a first elongated inflatable nitinol balloon and a second elongated inflatable nitinol balloon, each having an outer sealed terminus and an inner open fluid port, and a nitinol connector tube that fluidly couples the balloons and has a diameter smaller than the inflated diameters of the balloons. The first balloon is positioned within an arterial vessel and the second balloon is positioned within a venous vessel, with the connector tube spanning between the vessels. During systole, arterial pressure compresses the first balloon to drive fluid through the connector tube into the second balloon, thereby expanding the second balloon and increasing venous blood flow. Cyclic systolic and diastolic pressure variations cause fluid to shuttle between the balloons, producing a compliance-enhancing effect.

The application discloses a noninvasive calculation method of coronary microcirculation resistance and resistance index, and the method comprises the following steps: firstly, based on coronary computer tomography angiography data, blood vessel segmentation is carried out by using a U-Net convolutional neural network, and then a personalized 3D coronary stenosis branch vessel model is reconstructed; secondly, the information of multiple blood vessels (physiological parameters such as age, blood pressure and left ventricular volume in the systolic phase) is integrated, and the length, cross-sectional area, volume and other geometric structure parameters of a specific part of the blood vessel are measured and calculated; thirdly, fluid dynamics simulation is utilized to obtain the invasive CMR and IMR; fourthly, correlation analysis is carried out between the characteristic parameters and the CMR and IMR; fifthly, the characteristic parameters with high correlation are selected to carry out machine learning prediction, so as to realize noninvasive calculation of the CMR and IMR. The noninvasive method for evaluating the CMR and IMR can complete measurement in a short time and has high precision, and is convenient and safe.

A vascular implant is provided for increasing the efficiency of blood flow through an aorta. The vascular implant includes a tubular shunt having a lumen for allowing blood to pass between an aorta and an inferior vena cava. An expandable reservoir is sized for placement in the inferior vena cava. The reservoir has a first region coupled to the tubular shunt and may include a second region formed with an exit port for allowing some blood to escape the reservoir into the inferior vena cava. The exit port reduces the possibility of stagnation in the reservoir. High pressure blood from the aorta temporarily passes through the tubular shunt and into the reservoir, such as during systole. When blood pressure reduces in the aorta, blood from the reservoir passes from the reservoir and through the shunt where it reenters the aorta, such as during diastole.

The disclosure provides a device for non-invasive blood pressure measurement comprising a blood pressure cuff positioned around a limb with an optical sensor integrated into the distal end. The optical sensor comprises a transmission optical sensor with light source and detector on opposite sides of a digit distal to the inflatable portion. A processing device controls cuff inflation and deflation while capturing successive optical plethysmographic waveforms during deflation. The processing device high-pass filters waveforms to produce filtered signals with equal area above and below baseline, multiplies corresponding points of filtered waveforms to generate product values, and sums products to determine concordance measures. The device detects initial returning pulsations by identifying when initial low-amplitude optical pulsations have same shape as larger amplitude pulsations during deflation. Systolic blood pressure is determined when concordance measures indicate shape concordance between initial and subsequent optical pulsations. The device measures blood pressure and calculates ankle-brachial indices.

The application discloses a rotating speed control device and method, a ventricular assist system, a storage medium and equipment. The rotating speed control device is used for obtaining a target rotating speed of a motor; obtaining a rotating speed value of the motor and a flow value of a pump; outputting a control instruction to the motor according to the target rotating speed, the rotating speed value, the flow value and a preset feedback control law, so as to control the motor to drive the pump to deliver blood at a corresponding rotating speed; the feedback control law is created according to a first correlation model of the motor and the pump and a second correlation model of the pump and a human body, and rotating speed feedback control gain and flow feedback control gain in the feedback control law are obtained according to Lyapunov theory. The application can improve the reliability and accuracy of the feedback control gain, and can also stabilize the rotating speed at the target rotating speed, and the rotating speed is not affected by pressure changes in a systole period and a diastole period.

The present application relates to an ultrasonic diagnostic apparatus and an electrocardiogram waveform processing method. A setter (42) sets a plurality of heart rate intervals for an electrocardiogram waveform. A primary determiner (44) determines an interval satisfying a primary determination condition as a temporary stable interval within the plurality of heart rate intervals. A secondary determiner (46) determines the temporary stable interval as a stable interval in a case where the temporary stable interval satisfies a secondary determination condition. An end-diastole detector (48) and an end-systole detector (50) detect an end-diastole and an end-systole within a focus interval. A selection control section (33) controls selection of the focus interval at a time of change of the focus interval so that the changed focus interval becomes the stable interval.

A method for lowering systolic blood pressure in a patient exhibiting resistance to a antihypertensive therapy with one or more drugs, the method comprising administering to the patient ANAVEX®2-73 at a dose and frequency effective to provide a reduction of at least about 3 mmHg in one or more blood pressure parameters selected from trough sitting systolic, 24-hour ambulatory systolic, and maximum diurnal systolic blood pressures.

This application provides an ultrasound cardiac dynamic monitoring system and method, relating to the field of ultrasound cardiac function dynamic monitoring technology. The system includes: a patch-type ultrasound probe, a hydrogel patch, a wearable hardware module, and a cardiac function analysis module. The cardiac function analysis module is configured to: receive the ultrasound image; determine a target sampling line in the ultrasound image based on a reinforcement learning model; control the wearable hardware module to acquire M-mode images along the target sampling line; input the M-mode images into a deep learning model to output the key point positions of the left ventricular septum and the left ventricular posterior wall at end-diastole and end-systole based on the deep learning model; calculate the left ventricular ejection fraction (LVEF) based on the LVEF and the key point positions; the LVEF represents the dynamic monitoring and detection results of cardiac function. This system can improve the effectiveness and accuracy of dynamic cardiac monitoring.

A system for measuring cardiac parameters uses a movements sensor to generate a seismocardiographic signal and a cardiac parameters calculation unit. The cardiac parameters calculation unit provides for generating an envelope signal correlated to the seismocardiographic signal; identifies, in the envelope signal, signal segments having a repetitive pattern; identifies, among the signal segments, pairs of successive peaks such that a first peak of each pair of successive peaks is a systolic peak and a second peak of each pair of successive peaks is a diastolic peak; and calculates a systolic period and a diastolic period for each pair of successive peaks.

A prosthetic heart valve has a frame and a valvular structure coupled thereto. The valvular structure has multiple leaflets, with paired tabs from the leaflets forming commissure tab assemblies that couple the valvular structure to the frame. The frame is tapered with its inflow end diameter being smaller than its outflow end diameter. The valvular structure is constructed such that a flow channel formed by the leaflets is also tapered, with the inlet end cross-section being smaller than the outlet end cross-section. The commissure tab assemblies are attached to the frame with leaflet bending axes at or adjacent to the radially-inner surface of the frame. During systole, separation of blood flow induced by the tapered geometry of the flow channel generates an annular back flow region adjacent to the inner surface of the valve at the outflow end, which prevents the free edge of the leaflets from contacting the frame.

The invention provides a left atrial appendage image measurement method and system, electronic equipment and a storage medium, and relates to the technical field of left atrial appendage image measurement. The image measurement method comprises the following steps: transforming three-dimensional heart image data according to a spatial position transformation relationship to determine transformed three-dimensional heart image data; transforming the transformed three-dimensional heart image data according to the left auricle motion change function to determine four-dimensional heart image data; and analyzing the four-dimensional heart image data based on a preset AI algorithm to determine a target dynamic parameter of the left auricle in the heartbeat cycle. Based on the spatial position transformation relation and the left auricle motion change function, the dynamic parameter change curve of the left auricle in the whole heartbeat cycle (including the systolic period and the diastolic period) is introduced, and dynamic change information of the left auricle form in the heartbeat cycle is provided, so that the image measurement of the left auricle is more reliable and stable, and the measurement accuracy is improved. And the measurement accuracy is improved.

The invention provides an auxiliary ventricular intervention system, which relates to the technical field of medical instruments and comprises a diaphragm pump, a first catheter, a balloon and a pneumatic host. A balloon used for being implanted into the descending aorta to assist the heart is arranged on the surface between a two-way valve on a first catheter and the near end of the first catheter, the far end of the first catheter is used for being inserted into the ventricle, the balloon is connected with a pneumatic host air channel, and the near end of the first catheter is connected with a blood cavity of a diaphragm pump. A medium cavity of the diaphragm pump is connected with a pneumatic host through a gas circuit, the diaphragm pump is driven by the pneumatic host to suck or pump blood and drive the balloon to expand or contract at the same time, and the filling and emptying periods of the balloon are kept synchronous with the blood pumping action of the diaphragm, so that the systolic and diastolic periods of the heart are accurately corresponding; the number of elements used by the ventricular auxiliary intervention system is reduced, and the technical problems that an existing ventricular auxiliary intervention system is large in size, and the burden of a patient is easily increased are solved.

An electroanatomical mapping system generates a cardiac mechanical signal from a plurality of cardiac images and, more particularly, a plurality of ultrasound images. For each image, the system segments a blood pool / tissue border to detect a blob and defines a size metric, such as volume, area, maximum axial dimension, Zernike Moment, or the like for the detected blob. The plurality of size metrics thus generated can be output as a function of time to generate the cardiac mechanical signal. Local minima in the signal correspond to systole, while local maxima in the signal correspond to diastole.

A heart sound segmentation method includes: synchronously collecting physiological signals, the physiological signals include heart sound signals; obtaining a segmentation threshold corresponding to the heart sound signal, and segmenting the heart sound signal based on the segmentation threshold to obtain a first heart sound and a second heart sound; and determining a systolic duration and a diastolic duration of the heart sound signal according to the first heart sound and the second heart sound.

Devices, systems and methods affect cardiac function of a patient by delivering a stimulation to a right hemisphere of a diaphragm of the patient during a diastolic phase of a cardiac cycle of the patient, wherein the stimulation results in an asymptomatic, transient, partial contraction of the right hemisphere of the diaphragm; and delivering a stimulation to the left hemisphere of the diaphragm during a systolic phase of the cardiac cycle, wherein the stimulation results in an asymptomatic, transient, partial contraction of the left hemisphere of the diaphragm.

One aspect of the invention relates to a mechanical circulatory assistance device (100) comprising: a rod (11) for insertion into a blood vessel; a plurality of fins (12) attached to the rod (11), the plurality of fins comprising an electroactive material; a control module (14) connected to the plurality of fins (12), the control module (14) being configured to: obtain information relating to a systole of a cardiac cycle; and upon obtaining the information, command an actuation of the plurality of fins (12) so as to induce a displacement of the plurality of fins (12), the displacement being a folding of the plurality of fins (12) towards the rod (11) in a direction corresponding to a direction of blood flow in the blood vessel. Figure to be published with the abstract: Figure 1

A closure device for mitral valve leaflet repair, relating to the technical field of mitral valve leaflet repair. The closure device comprises an upper jaw assembly. One side of the upper jaw assembly is configured as an opening. A positioning forceps assembly is slidably connected to the inner wall of the opening. An end portion of the positioning forceps assembly is provided with a protruding portion. A hook-shaped slot is formed at the top of the upper surface of the protruding portion. By means of continuous abutment and approximation of a closure assembly, ports are finally connected to clamping arms, so that the closure assembly and the two clamping arms form an integrally formed structure, the closure assembly is connected to the basal portion of a mitral valve, and a first clamping arm and a second clamping arm are connected to the apical portion of the mitral valve. In this way, the mitral valve is tightly closed during systole to prevent backflow of blood from the left ventricle into the left atrium, thereby ensuring that blood can be pumped into the aorta from the left ventricle in a correct direction. Moreover, the closure assembly can implement closure without relying on external force. Compared with the prior art, the present invention eliminates the need for an external operating structure for controlling turning.

The invention provides a method for filtering T-wave interference, which comprises the following steps of: signal acquisition and preprocessing: acquiring an original electrocardiosignal, and performing three-stage filtering preprocessing on the original electrocardiosignal by adopting an IIR (Infinite Impulse Response) digital filter bank; identifying and positioning a T wave: processing the preprocessed electrocardiosignal, extracting morphological characteristics of the T wave in a suspected T wave region, and confirming the position, time range and frequency of the T wave according to the morphological characteristics of the T wave; filtering the T wave and reconstructing the electrocardiosignal: filtering a frequency component which mainly comprises T wave energy in the preprocessed electrocardiosignal by adopting a selective filtering algorithm, and reconstructing a signal of a frequency region where the T wave is located by adopting a cubic spline interpolation algorithm; according to the reconstructed electrocardiosignals, R waves are recognized, the real-time heart rate is calculated, the systolic period and the diastolic period of the heart are judged according to the time phase relation of the P waves and the R waves, and the parameter adjusting control signals are generated.

The present application relates to the technical field of medical image processing, and discloses a thoracoscope real-time imaging method, system, device and storage medium, which collects thoracoscope high-definition video stream, real-time electrocardiogram signals and near-infrared blood flow sensing data of a patient, dynamically calibrates the signals and electrocardiogram signals through pre-processing and Kalman filtering, and establishes a video frame and heart cycle phase mapping table; the thoracoscope high-definition video stream is input into a segmentation model, the thoracoscope high-definition video stream is segmented frame by frame, and a structure heat map is output; according to the video frame and heart cycle phase mapping table, the heart cycle is divided into a systole period and a diastole period, and corresponding dynamic compensation processing is performed; the near-infrared blood flow sensing data and the dynamically compensated video frame are first associated at a pixel level, and then the structure heat map is converted into a semi-transparent contour mark, and after rendering, a multi-view imaging result is output; the present application improves imaging efficiency.

The application provides a multi-inlet blood pumping device, and relates to the technical field of medical apparatuses.The blood pumping device comprises a pipe body, a pump assembly and a one-way valve; the head end of the pipe body enters the left ventricle after passing through the aorta; the tail end is connected with the pump assembly; the pipe body comprises a plurality of blood pumping vessels; the blood pumping vessels are provided with an inlet in the left ventricle and an outlet in the pipe wall located in the aorta; the blood pumping vessels are provided with the one-way valve; the one-way valve controls the outlet to be closed and the inlet to be opened when the blood pumping vessels pump blood; the inlet is closed and the outlet is opened when blood is transfused; the blood pumping vessels comprise a proximal apical pipe and a distal apical pipe; the pump assembly is electrically connected with a controller, and the controller controls the proximal apical pipe to pump blood first and the distal apical pipe to pump blood later.In the application, the blood in the left ventricle is layered and evacuated, the left ventricle side wall is driven to move in accordance with a healthy rhythm in the diastolic phase and the systolic phase, the blood flow movement of the intraventricular coronary artery and the coronary microcirculation is improved, the myocardial cell repair is promoted, and the symptoms of myocardial contraction weakness of the patient are effectively relieved.

Method and apparatus for the non-invasive detection of certain breathing conditions, certain sleep disordered breathing conditions, or assessment of the person's myocardial contractility and its dynamic changes, comprising steps of: determining the sleep or wake status of a person, monitoring circulatory pulse waveforms and amplitude normalized pulse wave systolic upstrokes recorded from a person's body and determining at least one index of the upstroke to characterize the strength of the contraction of the heart during the systolic upstroke during a series of heart beats relating to a breathing cycle or an absent anticipated breathing cycle of the patient, and determining that a certain change in a breathing condition, a sleep disordered breathing condition, or assessment of the person's myocardial contractility and its dynamic changes, has occurred when a specific change in the sleep disordered breathing analysis, and the at least one index of the upstroke has been detected.

The present invention relates to a non-invasive continuous blood pressure estimation device and a method thereof. The non-invasive continuous blood pressure estimation device according to an embodiment of the present invention comprises: a sensor unit including a photoplethysmography (PPG) sensor for detecting a PPG signal of a subject; a data collection unit for collecting the PPG signal from the sensor unit and storing the PPG signal together with time information; a feature extraction unit for extracting one or more biosignal features from among a systolic timespan (ST), a systolic timespan variation based on intersecting tangent point variation (STVIT), and a systolic timespan variation based on maximum slope point variation (STVMD), which are derived from a specific point of the PPG signal; and a blood pressure estimation unit for estimating systolic blood pressure (SBP) and diastolic blood pressure (DBP) by using the biosignal features extracted by the feature extraction unit.