105 results about "Systole" patented technology

Coaptation assist device for repairing cardiac valves and associated systems and methods are disclosed herein. A coaptation assist device configured in accordance with embodiments of the present technology can include, for example, a fixation member configured to press against cardiac tissue proximate to a native valve annulus, and a stationary coaptation structure extending away from the fixation member. The coaptation structure can include an anterior surface configured to coapt with a first native leaflet during systole and a posterior surface configured to displace at least a portion of a second native leaflet. The device also includes at least one sensor configured to detect parameters associated with at least one of cardiac function and device functionality. The sensors can be pressure sensors configured to detect left atrial pressure and / or left ventricular pressure.

The invention discloses a TAVR postoperative blood flow parameter complementing method based on CT-MRI fusion, and belongs to the technical field of crossing of medical image processing and computational fluid mechanics. A CT valve frame registration technology is adopted, an invisible artificial valve leaflet three-dimensional structure is reconstructed through valve frame information in a CT image and is coupled with a dynamic heart model, a complete valve mechanical and functional simulation platform is constructed, the problem of an imaging blind area is solved, hemodynamic parameters of an inlet and an outlet of a postoperative area are further collected in combination with 4D Flow MRI, and the artificial valve leaflet three-dimensional structure is obtained. The blood flow conditions of the upstream and the downstream of the artificial valve area at each stage of contraction and relaxation of the TAVR postoperative part are comprehensively restored, the temporal-spatial resolution and the physical authenticity of the boundary condition in fluid-solid coupling simulation are greatly improved, and the more real passive response of the valve leaflet under the action of the blood flow is obtained; and a reliable basis is provided for quantitative and mechanical risk analysis of postoperative complications such as thrombosis, perivalvular leakage and valve leaflet fatigue.

The invention relates to a heart health state detection method and device and electronic equipment, and the method comprises the steps: determining a plurality of first feature sets and a plurality of second feature sets in a short-time feature set based on a to-be-detected heart sound signal, each first feature set being determined based on the signal amplitude of the heart sound signal in a corresponding window at each sampling point, and each second feature set being determined based on the signal amplitude of the heart sound signal in the corresponding window at each sampling point; each second feature set is determined based on the duration of a first heart sound interval, a systolic period, a second heart sound interval and a diastolic period included in each cardiac cycle in the heart sound signal in the corresponding window; based on the heart sound signal to be detected, a time domain feature set, a frequency domain feature set and a Poincare map related parameter set in the long-time feature set are determined, the time domain feature set is determined based on the duration of each cardiac cycle, the frequency domain feature set is determined based on signal power, and the Poincare map related parameter set is determined based on a Poincare map generated based on the duration of each cardiac cycle; and inputting the short-time feature set and the long-time feature set into a set heart health state detection model to obtain a heart health state result.

The utility model relates to the technical field of medical apparatus and instruments, in particular to a heart valve forming ring implantation assembly which comprises a forming ring body which comprises an annular main body arranged in a chain type structure. The ring holder comprises a ring holding part, the ring holding part comprises a shell and a ring holding sleeve piece movably arranged at the lower end of the shell, the ring holding sleeve piece comprises a limiting block, a movable connecting part arranged at the upper end of the limiting block and a plurality of supporting rods arranged on the periphery of the lower end of the limiting block, and ring holding pieces are arranged at the tail ends of the supporting rods. The shell is provided with an operation assembly; and when the movable connecting part moves downwards, the plurality of supporting rods drive the ring holding piece to extend outwards. The forming ring can be adapted to forming ring bodies with various sizes; expansion of the valve ring cannot be caused, and the influence of the annular body on the valve ring in the contraction period is eliminated; the operation is simple and fast; a doctor can observe and use the device conveniently, more operation visual fields are provided, and the device is more suitable for small incision operations.

The present invention discloses a closure device for mitral valve leaflet repair, which relates to the technical field of mitral valve leaflet repair. The present invention includes an upper jaw assembly, one side of the upper jaw assembly is set to an opening shape, and a positioning clamp assembly is slidably connected to the inner wall of the opening. The end of the positioning clamp assembly is provided with an outer protrusion, and the top of the upper surface of the outer protrusion is provided with a hook-shaped groove. The present invention utilizes the continuous abutment and approach of the closure assembly to finally connect the port with the clamp arm, thereby forming an integrated structure between the closure assembly and the two clamp arms, so that the closure assembly is connected to the bottom of the mitral valve, and the first clamp arm and the second clamp arm are connected to the top of the mitral valve. Therefore, during the systole of the heart, the mitral valve is tightly closed, preventing blood from the left ventricle from flowing back to the left atrium, thereby ensuring that blood can be pumped from the left ventricle into the aorta in the correct direction, and the closure assembly can be closed without relying on external force. Compared with the existing technology, the external operating structure for controlling the turning is saved.

This application relates to a fully automated method and apparatus for quantitative analysis of myocardial acoustic contrast imaging. The method includes: acquiring myocardial acoustic contrast imaging images; segmenting the acquired myocardial acoustic contrast imaging images to obtain myocardial segmentation images; calculating the cardiac chamber area based on the myocardial segmentation images; automatically extracting the myocardial segmentation results at the end of cardiac systole using the periodic changes in cardiac chamber area; using the extracted end-systolic segmentation results as a mask to extract the corresponding position of each image as a target region for registration, thereby generating a one-to-one correspondence of registered image sequences; fitting a function model based on the pixel values ​​of each point in the registered image sequence; and generating a parametric image based on the registered image sequence and the fitted function model. Therefore, this application can perform fully automated quantitative analysis of myocardial acoustic contrast imaging.

Apparatus and methods for repairing a cardiac valve, e.g., a tricuspid valve, are provided. The apparatus may include a prosthetic device coupled to an elongated support coupled to a stent configured to be implanted within a vessel, e.g., the superior vena cava, to suspend and maintain the prosthetic device within the cardiac valve. The support may include a proximal, delivery portion detachably coupled, in a delivery state, to a distal, implantable portion coupled to the prosthetic device. The prosthetic device may be formed of biocompatible material coupled to a frame, and may have prosthetic leaflets that allows blood to flow therethrough in one direction during diastole, but prevents blood regurgitation during systole. The stent further may include features configured to resist migration of the stent within the vessel, as well as to prevent in-folding of the stent during deployment.

This invention discloses a non-contact electrocardiogram (ECG) measurement method using millimeter-wave radar. First, the original chest wall displacement signal acquired by the millimeter-wave radar is preprocessed to obtain a displacement feature branch input. Then, the original displacement signal undergoes cardiac sound band enhancement, wavelet denoising, and envelope extraction to obtain radar cardiac sound features. A hidden semi-Markov model is constructed to model the states of the first heart sound, systole, second heart sound, and diastole in the cardiac cycle, obtaining the posterior probability of the state at each time point. Next, the displacement features, radar cardiac sound features, and state probability features are input into a multi-branch convolutional fusion network, combined with a bidirectional long short-term memory network to achieve temporal correlation modeling, finally outputting the reconstructed human ECG result. This invention achieves non-contact ECG measurement without skin electrode contact by fusing the original mechanical displacement of the chest wall, the mechanical vibration features of the heart sounds, and the explicit state prior information of the cardiac cycle.

This invention provides an apparatus for repairing heart valves and a method for implanting anchors and repairing heart valves. The apparatus includes: a body; a component attached to the body at a first end and having a plurality of positioning cords extending laterally across a space between the component and away from a second end of the component opposite to the first end; a tube suspended from the plurality of positioning cords; and an adjustment cord extending through the tube. The method includes: implanting at least one annular anchor into the mitral valve annulus of a heart valve; implanting papillary anchors through each papillary muscle of the heart; delivering and positioning the apparatus for repairing the heart valve within the heart valve using at least one annular anchor and papillary anchors; and adjusting the apparatus to adjust the degree of atrial displacement of the mitral valve leaflets during ventricular systole.

A method for operating a blood pressure measuring apparatus includes the steps of: applying a measuring apparatus, containing a pressure unit and / or a pressure measuring unit, to a measurement point on the body; initialising the measuring apparatus by carrying out a reference measurement and / or by carrying out defined position changes to the measurement point and determining person-specific initialisation parameters; storing the person-specific initialisation parameters in a memory and control unit; carrying out at least one blood pressure measurement by applying a counter pressure to the pressure unit in a sub-systolic low-pressure range; maintaining the applied counter pressure within a plateau phase having a predefined duration and recording blood pressure time curve data during the predefined duration; converting the recorded blood pressure time curve data over the initialisation parameters into arterial blood pressure data over time.

The present application discloses a blood pump speed pulsation control method, system, and related products. The method: based on the electrical signal change information of the blood pump motor within a historical period, detects the start time of the N0 diastole and the start time of the N0 systole of the current patient's heart beat within the historical period; based on these start times, determines the start time of the N1 diastole and the start time of the N1 systole of the heart after the historical period. The method uses the patient's individual historical electrical signal change information as a basis to determine the future start time of the diastole and the start time of the systole of the current patient's heart, ensuring that the speed adjustment time of the blood pump motor is personalized to conform to the physiological contraction law of the individual heart, and realizing the specific output of the blood pump such as the blood pumping time and the blood pumping volume per time to flexibly follow the blood flow pulsation output of the heart beat, that is, to assist the blood pump in generating a pulsating flow synchronized with the natural heart beat, thereby effectively and reliably maintaining the patient's life safety.

A blood pressure monitoring device includes a wristband, a housing, and a display. The strap portion is adapted to secure the device to the wrist without obstructing blood flow. At least one sensor modality is disposed within the housing for obtaining sensor data from an artery in the wrist. In a preferred embodiment, a photoplethysmography sensor is incorporated in a housing to generate PPG waveform data. A processor within the housing is operable to calculate an average arterial pressure based on the extracted and calculated characteristics of the sensor data, and optionally to calculate diastolic and systolic blood pressures. Related methods and systems are also described.

In order to determine the presence or absence of pre-constriction with high accuracy on the basis of an image of a heart, a pre-constriction determination device (1) is provided with: an acquisition unit (101) that acquires a signal waveform indicating a time-series change in the area of each ventricle and each atrium region in the image of the heart; and a determination unit (104) that determines whether or not there is a pre-period contraction by comparing the time interval from the point in time when the area indicated by the signal waveform reaches the reference value to the point in time when the area reaches the reference value again with a predetermined threshold value.

Vascular blood flow modulation is disclosed using metallic compliance-enhancement devices that contain a sealed volume of fluid. The device includes a first elongated inflatable nitinol balloon and a second elongated inflatable nitinol balloon, each having an outer sealed terminus and an inner open fluid port, and a nitinol connector tube that fluidly couples the balloons and has a diameter smaller than the inflated diameters of the balloons. The first balloon is positioned within an arterial vessel and the second balloon is positioned within a venous vessel, with the connector tube spanning between the vessels. During systole, arterial pressure compresses the first balloon to drive fluid through the connector tube into the second balloon, thereby expanding the second balloon and increasing venous blood flow. Cyclic systolic and diastolic pressure variations cause fluid to shuttle between the balloons, producing a compliance-enhancing effect.

The present application relates to the field of assist devices and provides a left ventricular flexible assist device, wherein a catheter support of the device is arranged in a reflux catheter; a first opening is arranged at the top of the catheter support, a second opening is arranged at the bottom of the catheter support, and the side of the catheter support is a hollow structure; a trileaflet valve is fixedly connected to the inner side of the catheter support; a third opening is arranged at the top of the suction catheter, a fourth opening is arranged at the bottom of the reflux catheter, a fifth opening is arranged at the top of the reflux catheter, the third opening passes through the fourth opening and the second opening, and is fixedly connected to the bottom of the trileaflet valve; the support valve is arranged between the catheter support and the suction catheter; a blood discharge hole is arranged on the side of the reflux catheter, and a suction hole is arranged on the side of the suction catheter. The device provided by the present application can aspirate blood from the left ventricle during systole while avoiding the accidental aspiration of blood from the ascending aorta out of the body, and discharge blood into the ascending aorta during diastole while avoiding the accidental discharge of blood into the left ventricle.

A prosthetic heart valve, for example a tricuspid valve, may include a flexible membrane and a frame. The frame may be attached to the periphery of the tricuspid orifice. The diaphragm may be attached to the frame around a part of the perimeter of the orifice. Optionally the frame may be flexible. For example the frame may elastically flex between a substantially circular shape and / of an elliptical and / or crescent shape. Optionally there may not be a stiff cross piece crossing a central region of the orifice and connected on opposing sides of frame. In some embodiments, the diaphragm may take a dome shape during systole.

One aspect of the invention relates to a mechanical circulatory assistance device (100) comprising: - a stem (11) that is intended to be inserted into a blood vessel; - a plurality of fins (12) attached to the stem (11), the plurality of fins comprising an electroactive material; - a control module (14) connected to the plurality of fins (12), wherein the control module (14) is configured to: o obtain information relating to a systole of a cardiac cycle; and o on obtaining the information, control actuation of the plurality of fins (12) so as to cause the plurality of fins (12) to move, the movement being a folding of the plurality of fins (12) towards the stem (11) in a direction corresponding to a direction of blood flow through the blood vessel. Drawing_references_to_be_translated

The application discloses a noninvasive calculation method of coronary microcirculation resistance and resistance index, and the method comprises the following steps: firstly, based on coronary computer tomography angiography data, blood vessel segmentation is carried out by using a U-Net convolutional neural network, and then a personalized 3D coronary stenosis branch vessel model is reconstructed; secondly, the information of multiple blood vessels (physiological parameters such as age, blood pressure and left ventricular volume in the systolic phase) is integrated, and the length, cross-sectional area, volume and other geometric structure parameters of a specific part of the blood vessel are measured and calculated; thirdly, fluid dynamics simulation is utilized to obtain the invasive CMR and IMR; fourthly, correlation analysis is carried out between the characteristic parameters and the CMR and IMR; fifthly, the characteristic parameters with high correlation are selected to carry out machine learning prediction, so as to realize noninvasive calculation of the CMR and IMR. The noninvasive method for evaluating the CMR and IMR can complete measurement in a short time and has high precision, and is convenient and safe.

The present application discloses a blood pump flow adaptive control method, system and related products. The embodiments of the present application use the patient's individual historical electrical signal change information as a basis to determine the start time of the diastole and the start time of the systole of the current patient's heart in the future, which can ensure that the speed adjustment time of the blood pump motor is personalized and conforms to the physiological contraction law of the individual heart; wherein, the start time of the current beating period is determined according to the duration of one single historical beating period, and the start time of the next beating period is detected within the latest corresponding duration of the current beating period, which can achieve the specific outputs of the blood pump such as the blood pumping time and the blood pumping volume each time to flexibly follow the blood flow pulsation output of the heart beat in real time, that is, to assist the blood pump in generating a pulsating flow synchronized with the natural heart beat, thereby effectively and reliably maintaining the patient's life safety.

A vascular implant is provided for increasing the efficiency of blood flow through an aorta. The vascular implant includes a tubular shunt having a lumen for allowing blood to pass between an aorta and an inferior vena cava. An expandable reservoir is sized for placement in the inferior vena cava. The reservoir has a first region coupled to the tubular shunt and may include a second region formed with an exit port for allowing some blood to escape the reservoir into the inferior vena cava. The exit port reduces the possibility of stagnation in the reservoir. High pressure blood from the aorta temporarily passes through the tubular shunt and into the reservoir, such as during systole. When blood pressure reduces in the aorta, blood from the reservoir passes from the reservoir and through the shunt where it reenters the aorta, such as during diastole.

Apparatus and methods for repairing a cardiac valve, e.g., a tricuspid valve, are provided. The apparatus may include a prosthetic device coupled to an elongated support to suspend and maintain the prosthetic device within the cardiac valve. The support may include a proximal elongated shaft detachably coupled, in a delivery state, to a distal elongated shaft coupled to the prosthetic device. The proximal elongated shaft may detach from the distal elongated shaft at a detachment area within the patient responsive to actuation and components of the distal elongated shaft may lock to implant the prosthetic device and the distal elongated shaft within the patient. The prosthetic device may be formed of biocompatible material coupled to a frame, and may have prosthetic leaflets that allows blood to flow through in one direction during a phase of the cardiac cycle (e.g., diastole) but prevent blood regurgitation during the other phase (e.g., systole).

The disclosure provides a device for non-invasive blood pressure measurement comprising a blood pressure cuff positioned around a limb with an optical sensor integrated into the distal end. The optical sensor comprises a transmission optical sensor with light source and detector on opposite sides of a digit distal to the inflatable portion. A processing device controls cuff inflation and deflation while capturing successive optical plethysmographic waveforms during deflation. The processing device high-pass filters waveforms to produce filtered signals with equal area above and below baseline, multiplies corresponding points of filtered waveforms to generate product values, and sums products to determine concordance measures. The device detects initial returning pulsations by identifying when initial low-amplitude optical pulsations have same shape as larger amplitude pulsations during deflation. Systolic blood pressure is determined when concordance measures indicate shape concordance between initial and subsequent optical pulsations. The device measures blood pressure and calculates ankle-brachial indices.

The application discloses a rotating speed control device and method, a ventricular assist system, a storage medium and equipment. The rotating speed control device is used for obtaining a target rotating speed of a motor; obtaining a rotating speed value of the motor and a flow value of a pump; outputting a control instruction to the motor according to the target rotating speed, the rotating speed value, the flow value and a preset feedback control law, so as to control the motor to drive the pump to deliver blood at a corresponding rotating speed; the feedback control law is created according to a first correlation model of the motor and the pump and a second correlation model of the pump and a human body, and rotating speed feedback control gain and flow feedback control gain in the feedback control law are obtained according to Lyapunov theory. The application can improve the reliability and accuracy of the feedback control gain, and can also stabilize the rotating speed at the target rotating speed, and the rotating speed is not affected by pressure changes in a systole period and a diastole period.

A Windkessel simulation apparatus includes a flexible fluid container that cyclically fills with a perfusate fluid, such as blood, and helps deliver the perfusate fluid to a heart, by means of an elastic reactive squeezing mechanism that applies compressive force proportional to the pressure in the flexible fluid container. The apparatus acts as a hydraulic capacitor, similarly to how arteries act in the body-inflating during systole, and squeezing during diastole. In this way, the apparatus may help simulate a natural circulatory system for an organ, such as an ex vivo heart.

This invention discloses an intraperitoneal balloon-assisted pacing implant kit, comprising: a guiding component, a dilation catheter component, and an inflation / deflation component. The guiding component includes a first guidewire, a portion of which is located inside the pericardial cavity of the target heart. The dilation catheter component includes a main tube and a balloon. The main tube has parallel guiding and air intake channels. The first guidewire is slidably connected within the guiding channels, guiding the main tube into the body. The balloon is positioned on the main tube and connected to the air intake channel. The main tube has a groove along its axial direction. Guided by the first guidewire, the balloon is embedded in the pericardial cavity of the target heart. Air is introduced through the air intake channel, causing the balloon to extend along the groove and surround the outside of the ventricle. The inflation / deflation component is connected to the balloon. With the support of ECG gating technology, the balloon expands during cardiac systole and contracts during diastole within the pericardial cavity, thereby compressing the left and right ventricles during cardiac systole.

The present invention provides an image processing device for evaluating cardiac images and a method for identifying ventricular states. In this method, regions of interest are identified from multiple target images, grayscale value changes of multiple pixels in the regions of interest in those target images are determined, and one or more representative images are obtained based on the grayscale value changes. The target images are pixels within the endocardial contour of the left ventricle, with the boundaries of the region of interest roughly located on both sides of the bottom of the endocardial contour, and the region of interest corresponds to the mitral valve. Grayscale value changes are related to the movement of the mitral valve. The representative images are used to evaluate the state of the left ventricle. In this way, the end-systole and end-diastole of the heart can be quickly and accurately identified.

The present application relates to an ultrasonic diagnostic apparatus and an electrocardiogram waveform processing method. A setter (42) sets a plurality of heart rate intervals for an electrocardiogram waveform. A primary determiner (44) determines an interval satisfying a primary determination condition as a temporary stable interval within the plurality of heart rate intervals. A secondary determiner (46) determines the temporary stable interval as a stable interval in a case where the temporary stable interval satisfies a secondary determination condition. An end-diastole detector (48) and an end-systole detector (50) detect an end-diastole and an end-systole within a focus interval. A selection control section (33) controls selection of the focus interval at a time of change of the focus interval so that the changed focus interval becomes the stable interval.

The invention discloses an intrapericardial balloon pacemaker implantation set which comprises a guide assembly, an expansion catheter assembly and an inflation and deflation assembly, the guide assembly comprises a first guide wire, and part of the first guide wire is located in the pericardial cavity of a target heart; the dilation catheter assembly comprises a main catheter body and an air bag, the main catheter body is internally provided with a guide channel and an air inlet channel which are parallel to each other, a first guide wire is slidably connected into the guide channel and guides the main catheter body to move into the human body, the air bag is arranged on the main catheter body and connected with the air inlet channel, and the main catheter body is provided with a slot in the axial direction of the main catheter body. Under the guidance of the first guide wire, the air bag is embedded in a pericardial cavity of a target heart, air is fed through the air inlet channel so that the air bag can stretch out along the groove seam to wrap the outer side of a ventricle, the inflation and deflation assembly is connected with the air bag, and under the support of an electrocardio gating technology, the air bag can be inflated in the pericardial cavity in the systolic period or exhausted in the diastolic period to retract. Therefore, left and right ventricles are extruded during systole.

In some embodiments, a computer-implemented method of measuring heart rate analytics using raw photoplethysmography (PPG) data is provided. A computing system determines a plurality of frequency peaks in the raw PPG data using a Fourier analysis. The computing system determines a plurality of selected frequency peaks from the plurality of frequency peaks. For each selected frequency peak of the plurality of selected frequency peaks, the computing system creates filtered PPG data by applying a frequency of the selected frequency peak as a high-pass filter to the raw PPG data; detects diastole peaks and systole valleys in the filtered PPG data; and performs one or more pulse quality checks on the detected diastole peaks and systole valleys. The computing system uses diastole peaks and systole valleys associated with a lowest selected frequency peak that passed the pulse quality checks to determine a heart rate analytic measurement.

A method for lowering systolic blood pressure in a patient exhibiting resistance to a antihypertensive therapy with one or more drugs, the method comprising administering to the patient ANAVEX®2-73 at a dose and frequency effective to provide a reduction of at least about 3 mmHg in one or more blood pressure parameters selected from trough sitting systolic, 24-hour ambulatory systolic, and maximum diurnal systolic blood pressures.