A vehicle wheel lathe fixture, including an upper cover, a coupling base, a floating disc, a driving seat, a sliding sleeve, a finger-shaped press jaw, a rotating shaft, a sliding shaft, an end-face positioning block base, an end-face positioning block, a positioning pin, a radial positioning block, a radial pull rod, a hydraulic power chuck, a disc spring sleeve, a disc spring, a disc spring positioning column, a press cover, a hydraulic power chuck mounting base and a dust cover. Embodiments of the invention have the characteristics of reliable work, stable operation and wide compatibility range, and is applicable to vehicle wheel mechanical processing lathes.