49 results about "Intervertebral disc" patented technology

This invention discloses a device for modeling intervertebral disc degeneration in rats, comprising a first barrel, a second barrel disposed on top of the first barrel, and a connecting cylinder disposed between the first and second barrels. An operating port is provided on the outer wall of the connecting cylinder. A restraining collar is fixedly sleeved on the end of the outer wall of the connecting cylinder. Opposite ends of the outer walls of the first and second barrels are slidably sleeved with the restraining collar. A locking component is disposed on the side of the first and second barrels, used to lock the first and second barrels in place. This invention utilizes the cooperative use of the first barrel, second barrel, connecting cylinder, and locking component. Under the action of the locking component, the first barrel, second barrel, and connecting cylinder can be assembled into a whole, and the connecting cylinder can rotate relative to the first and second barrels, thereby changing the position of the operating port on the connecting cylinder corresponding to the fixed rat.

The present application relates to the technical field of intervertebral disc degeneration treatment and drug delivery, and discloses an injectable oxynate sodium functionalized hydrogel microsphere loaded with TGFbeta3 and application, by loading glycolysis inhibitor SO in the GelMA microsphere matrix and post-adsorbing TGFbeta3, on the one hand, SO is used to inhibit the excessive active glycolysis in the degenerative microenvironment, reduce lactic acid accumulation and relieve inflammation, on the other hand, TGFbeta3 is used to effectively promote the synthesis of collagen and proteoglycan, both of which synergistically act from the two aspects of metabolic regulation and matrix synthesis, and jointly promote the recovery of intervertebral disc homeostasis, therefore, the oxynate sodium functionalized microsphere loaded with TGFbeta3 constructed by the present application can realize the synergistic treatment of multiple targets and multiple pathways by synchronously delivering metabolic regulators and synthesis promoters, so as to more effectively delay or reverse the intervertebral disc degeneration process, and finally achieve the beneficial effect of the double repair effect of simultaneously regulating abnormal glycolysis metabolism of degenerative nucleus pulposus cells and promoting extracellular matrix synthesis.

A spinal fixation system includes an expandable disc replacement body and an angle-setting disc replacement holder. The expandable disc replacement body includes a first wall, a second wall, and a hinge connecting the first wall and the second wall. An insertion instrument may be used to implant the expandable disc replacement body into a subject. The disc replacement holder is positioned between the first wall and the second wall, and an angle and / or height between the first wall and the second wall can be varied by adjustment of the disc replacement holder and locked into place using locking mechanisms.

This invention discloses the application of a Cav3.2 inhibitor in the preparation of a drug for treating intervertebral disc degeneration. Z944 can block the activation level of Cav3.2 in nucleus pulposus cells, effectively alleviating lipid metabolism disorders and cellular biological behavior disorders induced by abnormal mechanical stress, and ultimately reducing intervertebral disc degeneration. This demonstrates that Z944 is a drug with clinical application potential, which can be used to alleviate the pain and burden of patients with low back pain and improve their quality of life.

The present disclosure provides compositions and methods for treating and preventing localized nociception, inflammation, or morphological changes associated with joint disease or illness, back or spine conditions or disorders, and musculoskeletal diseases or dysfunction.

The application discloses application of serine or a pharmaceutically acceptable salt thereof in preparation of a medicine for preventing or treating intervertebral disc degeneration, and a medicine composition containing the active ingredient, and belongs to the technical field of biological medicine. The application takes serine as the active ingredient, provides application of the serine in preparation of the medicine for treating intervertebral disc degeneration, the medicine can supplement serine exogenously, corrects redox imbalance of nucleus pulposus cells, reverses cell aging, and thus can improve the intervertebral disc degeneration process. The application further provides a corresponding medicine composition, which can be prepared into a local injection preparation or an oral preparation, wherein the local injection preparation can be combined with a biomaterial to construct a slow-release delivery system, so that long-acting targeted drug delivery is achieved.

The spinal disc stretching device of the present invention comprises: a spinal disc stretching device for decompressing the spine along the longitudinal direction of the subject's spine while the subject is lying prone; an upper body support member that extends in one direction, supports the subject's upper body, and is rotatable with respect to the ground; a lower body support member that extends in one direction, supports the subject's lower body, and is rotatable with respect to the ground; an intermediate support member formed between the upper body support member and the lower body support member, on which a part of the subject's waist is positioned, and which performs a seesaw motion on both sides around a support member located at the bottom; a driving unit provided in each of the upper body support member and the lower body support member to cause each of the upper body support member and the lower body support member to rotate with respect to the ground; and a control unit for adjusting the rotation angle of each of the upper body support member and the lower body support member. The upper body support member is characterized by being arranged to rotate so as to rise relative to the ground.

This invention discloses a lactate reactor capable of inhibiting intervertebral disc degeneration and its preparation method. The lactate reactor is an injectable gel microsphere loaded with lactate-catalyzing nanoparticles and matrix cell-derived factor SDF-1α. The lactate-catalyzing nanoparticles are mesoporous silica nanoparticles, whose mesopores are coated with lactate dehydrogenase, nicotinamide adenine dinucleotide, alanine aminotransferase, and glutamate, and whose surface is coated with an oxidized sodium alginate layer via a Schiff base reaction. This invention can efficiently convert pathological lactate in the nucleus pulposus microenvironment into alanine, which inhibits degeneration, while simultaneously recruiting stem cells to synergistically inhibit the process of intervertebral disc degeneration.

Methods and systems for electrical property tomographic imaging are presented. Electrical properties such as conductivity and permittivity of intervertebral discs are computed with improved accuracy and displayed for clinical personnel evaluation.

The invention relates to a computer-implemented method for the simulation of at least a part of a spine, comprising the steps: executing of an image segmentation on at least one image, particularly from medical sectional imaging such as a CT and / or an MR image, of at least a part of the spine, for obtaining a segmentation mask; deriving of one or more vertebral body geometr(y / ies) and / or intervertebral disc geometr(y / ies) as a surface mesh from the segmentation mask; processing, in particular smoothing, of the surface mesh of the vertebral body geometry and / or the intervertebral disc geometry; filling of a volume being enveloped by the surface mesh; and generating of a finite element method model, also referred to as FEM model, from the volume; wherein, prior to smoothing, extracting of contact nodes is conducted, wherein the contact nodes are nodes of the surface mesh, which are adjacent to or in contact with nodes of a further surface mesh of another adjacent element of the part of the spine, in particular of an adjacent intervertebral disc and / or an adjacent vertebral body, for the modeling of contact points of the vertebral body geometry and / or the intervertebral disc geometry.

A dynamic thoracic disc prosthesis comprising a lower plate and a upper plate, wherein the lower plate has a rough, toothed lower surface for anchoring and a upper surface formed by multiple sliding surfaces, including: an anterior convex, sliding hemispherical surface, an intermediate semicircular surface, and a posterior semicircular surface, the intermediate semicircular surface being provided with an anterior and a posterior stop; the upper plate has a rough, toothed upper surface for anchoring and a lower surface formed by multiple sliding surfaces, including: an anterior concave hemispherical surface, an intermediate semicircular surface, and a posterior semicircular surface, the intermediate semicircular surface being provided with an anterior and a posterior curved cavity. The different sliding surfaces originate from the same geometric center or center of rotation.The upper plate is coupled to the lower plate via the corresponding sliding surfaces, allowing movement of the upper plate over the lower plate in anterior, posterior, right lateral tilt, left lateral tilt, right center-lateral rotation, and left center-lateral rotation directions, thus replicating the flexion, extension, lateral, and rotation movements of the thoracic spine.

Intervertebral devices and systems, and methods of their use, are disclosed having configurations suitable for placement between two adjacent vertebrae, replacing the functionality of the disc therebetween. Intervertebral devices and systems contemplated herein are implantable devices intended for replacement of a vertebral disc, which may have deteriorated due to disease for example. The intervertebral devices and systems are configured to allow for ample placement of therapeutic agents therein, including bone growth enhancement material, which may lead to better fusion between adjacent vertebral bones. The intervertebral devices and systems are configured for use in minimally invasive procedures, if desired.

The present application relates to the technical field of medicine, and especially relates to a combined Chinese and western medicine composition and application thereof, wherein the combined Chinese and western medicine composition comprises Chinese patent medicine and western medicine; the raw material of the Chinese patent medicine comprises Strychnos seed powder, Earthworm, Codonopsis, Poria cocos, Atractylodes, Chuanxiong, Salvia miltiorrhiza, Panax notoginseng, Radix et Rhizoma Bovis, and Radix Glycyrrhizae; and the effective component of the western medicine is diclofenac; the application of the combined Chinese and western medicine composition in preparation of a lumbar pain medicine; the application is for preparation of intervertebral disc-derived lumbar pain medicines of different syndromes; the syndrome is preferably qi and blood deficiency syndrome; the combined Chinese and western medicine composition can effectively treat intervertebral disc-derived lumbar pain of different syndromes through mutual cooperation between the Chinese patent medicine and the western medicine, and the curative effect is more obvious for intervertebral disc-derived lumbar pain of qi and blood deficiency syndrome.

The invention discloses a lumbar disc herniation interpretable diagnosis system based on cross-style consistency semi-supervised segmentation. The method comprises the following steps: firstly, carrying out style diversification processing on a lumbar axial MRI image through Bessel transformation to generate an image pair for consistency learning; the aggressive student model processes the stylized image and carries out cooperative training through cross pseudo supervision, and the robust student model provides a reliable prediction target through smooth parameter updating; the trained model can realize automatic segmentation of an intervertebral disc and a posterior spinous process area. Based on the segmentation result, the system adopts a geometric rule algorithm to quantify the prominence degree, and automatically generates a grading result and a visual report according to a clinical MSU grading standard. According to the method, the dependence on labeled data is reduced, the interpretability of the model is improved, and efficient and accurate lumbar disc herniation auxiliary diagnosis with clinical guiding significance can be realized.

The present application relates to the technical field of orthopedic artificial joint design and manufacturing, in particular to an intervertebral disc prosthesis and a preparation method thereof. The first plate body of the intervertebral disc prosthesis is provided with a semispherical groove on the side away from the first fixing seat; the second plate body is provided with a connecting slot on the side away from the second fixing seat; the nucleus pulposus prosthesis comprises a semispherical convex surface and a base, the semispherical convex surface is movably connected with the semispherical groove, and the base is connected with the connecting slot; the surfaces of the first plate body and the second plate body are both provided with gradient trabeculae, and the surfaces of the semispherical groove and the semispherical convex surface in contact with each other are both metal ceramic interfaces formed by zirconium-niobium surface oxidation. The upper end plate of the intervertebral disc prosthesis can keep relative movement with the nucleus pulposus prosthesis, and the contact friction interface of the relative movement is a metal ceramic interface formed by zirconium-niobium surface oxidation, so that the friction surface can reduce abrasion to the greatest extent, the wear resistance of the prosthesis is improved, the service life of the prosthesis is prolonged, the loosening of the prosthesis is improved, the metal allergic reaction and metal artifacts are reduced.

This invention belongs to the field of medical technology and discloses an anatomically optimized spinal disc fusion cage and its design method. Based on the patient's personalized three-dimensional anatomical information of the diseased intervertebral disc, a personalized overall intervertebral fusion cage is designed. The designed overall intervertebral fusion cage is segmented into different types of personalized AOFS intervertebral fusion cages; these different types of personalized AOFS intervertebral fusion cages include, but are not limited to: ALIF (anterior fusion cage), PLIF (posterior fusion cage), TLIF (lateral posterior fusion cage), and LLIF (lateral fusion cage). This invention proposes a novel anatomically optimized spinal disc fusion cage design tailored to individual patients, fully integrating the advantages of simple decompression and decompression plus fusion surgery techniques. Its purpose is to optimize the biomechanical environment of adjacent segments after fusion surgery, reduce or prevent the possibility of reoperation after the initial fusion surgery, and thus prolong the surgical lifespan.

The application discloses an experimental animal spinal column specimen dissection instrument and a dissection method. The dissection instrument comprises a fixing device, a scanning device, a cutting device and a control device. The fixing device is used for fixing the experimental animal spinal column specimen. The scanning device is used for scanning the fixed experimental animal spinal column specimen and transmitting a scanning image to the control device. The cutting device cuts the experimental animal spinal column specimen according to a cutting instruction of the control device or manually. The dissection instrument of the application integrates the fixing and cutting functions, significantly improves the efficiency and precision of the experimental animal spinal column specimen dissection, reduces the error and labor intensity of manual operation, makes the dissection process more consistent and reliable, and has high flexibility and adaptability, so that the dissection instrument can meet the dissection requirements of spinal column specimens with different sizes and curved shapes, and provide more reliable dissection samples and experimental data support for the fields of spinal column disease research, spinal cord injury repair and artificial vertebral body / intervertebral disc implant research and development.

An implant is provided, and the implant includes a body, a limiting portion and a filling portion. The body has a first end portion, a second end portion opposite to the first end portion, and a middle portion disposed between the first end portion and the second end portion. The limiting portion includes a first solid structure and is located at the first end portion. The filling part includes an elastic structure and is located from the middle portion to the second end portion. A diameter of the first end portion of the body is greater than a diameter of the middle portion, and a diameter of the second end portion is greater than the diameter of the middle portion.

1. Name of the product in this design: Waist support belt (II). 2. Application of this design: This design is intended for use as a waist support belt to tighten the waist, support the abdomen, and treat lumbar disc herniation, lumbar muscle strain, and lumbar intervertebral disc strain. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present invention relates to a mechanical inversion device equipped with a dynamic balance mechanism and a continuous inversion angle adjustment system, which is designed to reduce axial pressure on the spine, improve nutrition of the intervertebral discs, and prevent musculoskeletal injuries. Common problems in previous technologies include creating asymmetrical pressure on the spine, the inability to precisely adjust the inversion angle, and the user's difficulty in returning from the inversion position to the upright position.\nIn this invention, a dynamic balance system based on symmetrical distribution of body mass, along with an angle adjustment system from 0 to 180 degrees, is presented, which allows for gradual, safe, and fully controlled inversion. The structure of the device includes an adjustable backrest, stabilizing brackets, a multi-stage stabilization frame, and a highly sensitive rotation axis that allows the user to return the device to an inverted or upright position without applying much force and with minimal resistance by simply moving the arm.\nThis design reduces mechanical pressure on the discs, increases the distance between the vertebrae, reduces muscle spasm, improves the circulation of intervertebral fluids, and ultimately prevents unnecessary surgeries. Also, the presence of predetermined angle markings allows for precise control of the inversion process for both novice and professional users.\nApplications of the device include spinal rehabilitation, physiotherapy, prevention of occupational injuries, improvement of sports performance, and treatment of vertebral compression disorders.

An expandable interbody device used as a prosthesis during spinal surgery. The expandable interbody device is configured to be inserted into the space between spinal disks to provide stability. The expandable interbody device includes a drive block, a linkage block, a drive screw, a first endplate, a second endplate, and at least two linkages. Rotation of the drive screw causes movement of the linkage block relative to the drive block and / or movement of the first endplate relative to the second endplate.

This invention discloses a 2D and 3D collaborative learning method for MRI lumbar spine and intervertebral disc segmentation, belonging to the field of intelligent medical image analysis technology. The method performs anisotropic resampling, intensity normalization, and region clipping on lumbar spine MRI data, and then inputs these data into 2D and 3D segmentation branches respectively. Cross-dimensional information interaction is achieved through bidirectional mapping from slice to volume and from volume to slice. A dynamic gating mutual learning mechanism is constructed based on confidence, consistency, and axial continuity to suppress low-confidence pseudo-supervision noise. Furthermore, anatomical topological priors are introduced into the segmentation results to perform instance separation, segment labeling, and topological validity correction on the vertebral bodies and intervertebral discs. Experiments demonstrate that this method can significantly improve the segmentation accuracy of complex anatomical structures and effectively solve the boundary ambiguity problem in anisotropic data. This invention forms a 2D and 3D collaborative learning segmentation approach that is both innovative and interpretable.

This application relates to the field of traditional Chinese medicine (TCM) technology, disclosing a TCM compound composition, its preparation method, and its application in treating discogenic low back pain. The TCM compound composition comprises the following components in parts by weight: Astragalus membranaceus 30g, Ligusticum chuanxiong 18g, Angelica sinensis 9g, Rehmannia glutinosa (processed) 18g, Paeonia lactiflora (fried) 18g, Codonopsis pilosula 9g, Bupleurum chinense 9g, Poria cocos 9g, Stephania tetrandra 9g, Aconitum carmichaelii (processed) 9g, and Angelica pubescens 9g. This TCM compound composition improves the metabolism and structural state of multifidus muscle, restores the mechanical stability of spinal segments, reduces the continuous input of abnormal mechanical stimulation from the source, thereby inhibiting the activation of the Piezo1-Netrin-1 axis, reducing vascular and sensory nerve ingrowth, and ultimately resulting in the protection of the cartilaginous endplate structure and improved pain sensitivity.

The present invention relates to a poly(methyl methacrylate) (PMMA) based bone cement composition comprising a softener and the use of said bone cement composition in discoplasty procedures. The use is characterized by injection of the composition into a disc, hence stabilizing the intravertebral disc, reducing lower back pain and increasing life quality in the affected subject.

1. Name of the product in this design: Waist support belt (I). 2. Application of this design: This design is intended for use as a waist support belt to tighten the waist, support the abdomen, and treat lumbar disc herniation, lumbar muscle strain, and lumbar intervertebral disc strain. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This invention provides an intervertebral disc degeneration assessment system based on MRI T2-mapping and big data, belonging to the field of intervertebral disc degeneration assessment technology. The image data analysis module collects clinically relevant data to obtain core characteristic data of intervertebral disc degeneration; the degeneration state matching module monitors the changing patterns of disease progression, obtains dynamic characteristic data of degeneration, and generates degeneration state matching data; the degeneration impact quantification module calculates the degeneration impact coefficient; and the multi-dimensional assessment and control module performs phased real-time assessment of the intervertebral disc degeneration process, generating degeneration grading results and intervention suggestions. This invention integrates MRI T2-mapping images and clinical data, employs multimodal feature extraction, dynamic temporal analysis, and a two-dimensional correction mechanism, and combines a hybrid model to construct a multi-stage assessment system. This achieves accurate grading and dynamic monitoring of intervertebral disc degeneration, generates personalized intervention suggestions, improves the objectivity and efficiency of assessment, provides a scientific basis for clinical diagnosis and treatment, and assists in early intervention and prognosis improvement.

This utility model discloses a depth-limiting sheath assembly for endoscopic-assisted anterior cervical surgery, comprising an outer sheath and an inner sheath, the inner sheath being inside the outer sheath. The outer sheath has a depth-limiting locking block at its tip, which, during operation, can be locked in front of the cervical vertebrae to limit the depth of the sheath and endoscope. One end of the outer sheath is fixedly connected to a receiving cavity, and a pressure block is disposed within the receiving cavity. One end of the pressure block is connected to the receiving cavity via a first spring, and the pressure block is slidably connected to the receiving cavity. This utility model provides a depth-limiting sheath assembly for endoscopic-assisted anterior cervical surgery, which, through the relative movement of the spring-loaded pressure block between the endoscope and the sheath, limits the depth and allows for relative adjustment of the endoscope's position, facilitating observation of the intervertebral discs.