388 results about "Intervertebral disc" patented technology

The invention discloses an in-vitro bionic mechanical testing system and method for spinal skeletal muscles, and particularly relates to the field of mechanical testing, and the system comprises a bionic construction module, a finite element modeling module, a multi-axis mechanical loading module, an iterative calculation module and a correction module; through modular design, the system comprises a vertebral body unit, an intervertebral disc simulation assembly and a skeletal muscle simulation unit, each assembly is customized according to anatomical features of a human body, a finite element modeling module is utilized to generate a three-dimensional model, a multi-directional mechanical load is applied, and response data is collected; experimental data are input into the finite element model for iterative calculation, so that stress distribution, a strain field and kinematic deviation are compared; if the error exceeds a preset threshold value, the model parameters and the physical parameters are corrected until the experiment and simulation results converge; and finally, based on the optimized finite element model, predicting a failure mechanism of the spinal skeletal muscle under a complex load, and evaluating the risks of fracture, hairline fracture, nucleus pulposus protrusion and muscle strain.

The embodiment of the invention provides a spine image recognition method and related equipment. The spine image recognition comprises the following steps: acquiring a spine image to be detected, and preprocessing the spine image to be detected to obtain a target spine image; the target spine image is input into a key point recognition model, position information output by the key point recognition model for each section of vertebral body in the target spine image is obtained, and the position information is marked on the target spine image and at least comprises positioning frame information, a vertebral body name and angular point coordinates; the key point identification model comprises a CBAM module; correcting and adjusting the position information to obtain corrected position information; and performing intervertebral disc positioning and vertebra identification according to the corrected position information. According to the technical scheme, the improved key point recognition model is adopted, the positioning frame, the cone name and the angular point coordinates are directly output without depending on a segmentation model, the process is simplified, and the detection speed and robustness are improved.

The invention specifically discloses an automatic generation method for a cervical vertebra disease rehabilitation prescription, and the method comprises the steps: constructing a cervical vertebra image feature automatic measurement system based on computer vision and deep learning, so as to monitor the training motion quality of a patient in real time, and obtaining the kinematics parameters of rehabilitation exercise training; acquiring a medical image and clinical data of a patient, and standardizing the medical image to construct a standard space of a multi-modal medical image; performing automatic segmentation and anatomical structure calibration on a vertebral body-intervertebral disc based on the standard space to obtain fusion image features; and constructing a multi-modal hierarchical decision model fusing the image features, the kinematics parameters and the clinical data to carry out quantitative analysis on pathological feature parameters, and outputting a standardized illness state assessment result conforming to international clinical guidelines. The dynamic optimization of the treatment scheme can be realized through a feedback mechanism, and the treatment effect is improved.

The present technology includes patient-specific spinal fusion devices, which may include an interbody implant that is designed to be positioned within a disc space between two vertebral bodies and one or more fixation elements that can anchor the interbody implant to the vertebral bodies. The fusion devices include one or more retention mechanisms for retaining the fixation elements within corresponding lumens or bore holes extending through the interbody implant. Methods for designing and manufacturing patient-specific spinal fusion devices are also described herein.

An access device for accessing an intervertebral disc having an outer shield comprising an access shield with a larger diameter (˜16-30 mm) that reaches from the skin down to the facet line, with an inner shield having a second smaller diameter (˜5-12 mm) extending past the access shield and reaches down to the disc level. This combines the benefits of the direct visual microsurgical / mini open approaches and the percutaneous, “ultra-MIS” techniques.

The present invention relates generally to implants and tools for the fixation or fusion of joints or bone segments. These tools include tissue dilators and protectors. Other tools include broaches used to shape bores in bone. The tools can also include a system for removing an implant from bone. Implants can include assemblies of one or more implant structures that make possible the achievement of diverse interventions involving the fusion and / or stabilization of lumbar and sacral vertebra in a non-invasive manner, with minimal incision, and without the necessitating the removing the intervertebral disc. Implants for fusing both sacroiliac joints of a patient include a long implant that extends across both sacroiliac joints.

Various embodiments of cervical plates for treating the spine are provided. The cervical plates include an access surface and a bone facing surface. The cervical plate further includes at least one hole between the access surface and the bone facing surface. The hole includes a trajectory surface that guides an anchor into a corner or edge of a vertebral body, wherein a portion of the hole extends into the disc space region. In some embodiments, the cervical plate includes a ledge to support high angle screw insertion. In some embodiments, an interbody implant is provided. The cervical plate and the interbody spacer can have a corresponding curvature.

The invention discloses a rat caudal vertebra intervertebral disc degeneration molding device which comprises an anesthesia box, a tail outlet hole is formed in the anesthesia box, a bearing table is arranged on the outer side of the anesthesia box, an arc-shaped locking plate is slidably installed on the bearing table, a containing groove is formed between the arc-shaped locking plate and the bearing table, and a sleeve is slidably installed on the arc-shaped locking plate in the circumferential direction; a puncture cylinder is in threaded connection with the interior of the sleeve, a graduated scale is axially arranged on the outer side wall of the puncture cylinder, a puncture needle is installed in the puncture cylinder and comprises a base and a needle head connected to the base, the base is installed in the puncture cylinder, the needle head sequentially penetrates through the puncture cylinder, the sleeve and the arc-shaped locking plate and then extends into the containing groove, and a bandage is arranged above the bearing table. An X-ray machine is arranged on the periphery of the bearing plate. The invention further discloses a rat caudal vertebra intervertebral disc degeneration modeling method using the rat caudal vertebra intervertebral disc degeneration modeling device. According to the rat caudal vertebra intervertebral disc degeneration modeling device and method, few tools are used, the process is simple, and application and popularization are convenient.

The present disclosure relates to an artificial lumbar disc and provides a lateral approach artificial disc that is inserted laterally rather than anteriorly of the spine, thereby preventing damage to blood vessels or other organs that may occur when an anterior access artificial disc is inserted from the front, shortening the surgical time, preventing dislodgment of the artificial disc, and improving the surgical prognosis. The artificial disc is inserted between two adjacent vertebrae and includes an upper plate contacting an upper vertebra, a lower plate contacting a lower vertebra, and an inserter inserted between the upper plate and the lower plate to allow the upper plate to rotate by a set angle with respect to the lower plate, and an upper wing portion and a lower wing portion are formed on the upper plate and the lower plate.

Methods and systems for electrical properties tomography imaging are presented. Electrical properties such as conductivity and permittivity of intervertebral discs are calculated with improved accuracy and displayed for assessment of clinical personnel.

The invention relates to a self-healing bionic intervertebral disc capable of improving service stability and a nucleus pulposus preparation method of the self-healing bionic intervertebral disc, and belongs to the field of bionic implant prostheses. The self-healing bionic intervertebral disc capable of improving the service stability is composed of an upper end plate, a bionic fibrous ring layer, a lower end plate and a bionic nucleus pulposus, the bionic nucleus pulposus adopts dynamic cross-linked hydrogel to simulate the viscoelasticity and moisture regulation function of a natural nucleus pulposus, and the buffering and self-healing characteristics of the bionic intervertebral disc are achieved; the bionic fiber ring layer achieves gradient mechanical properties through directionally-arranged composite materials, and three-dimensional physiological movement of the artificial intervertebral disc close to the lumbar vertebra of a human body is achieved. The bionic intervertebral disc provided by the invention is matched with viscoelasticity of a natural intervertebral disc, recovers natural matching with three-dimensional physiological movement of a human spine, can buffer dynamic load and maintain intervertebral height, can perform micro-injury self-repair through dynamic crosslinking of chemical bonds in bionic nucleus pulposus, and has a good application prospect. And the kinematic mechanical stability of long-term service in a human body is realized.

Disclosed methods, devices, and systems are suitable for performing minimally-invasive procedures for accessing the intervertebral space along an oblique pathway with an insertion instrument that holds a disc implant, and reorienting the angular relationship between instrument and implant while the implant is inside the body (for example at or within the disc space).

The invention discloses a patient-specific finite element model-based vertebroplasty optimization method and a related device. The method comprises the following steps of: constructing a patient-specific three-dimensional spine model according to a vertebral bone structure and a vertebral soft tissue structure; discretizing the patient-specific three-dimensional spine model into tetrahedral finite element grids, endowing each finite element unit with bone material attributes according to pixel values of CT scanning images, and endowing intervertebral disc and ligament soft tissue structures with soft tissue material attributes; determining an optimal bone cement injection path and an optimal bone cement injection amount of the tetrahedral finite element mesh; and simulating the vertebroplasty in the tetrahedral finite element mesh, predicting the stress distribution of the vertebrae, the rigidity of the vertebrae and the stress change of the adjacent vertebrae after the operation, and presenting the simulation result of the simulated vertebroplasty in a three-dimensional visual form. According to the method, personalized optimization and prediction of preoperative simulation of the vertebroplasty are realized by constructing the patient-specific finite element model, and an efficient auxiliary reference operation scheme is provided for an operator.

The invention relates to application of mitochondrial E3 ligase MAPL and an inhibitor of the mitochondrial E3 ligase MAPL in preparation of a medicine for treating intervertebral disc degeneration. MAPL increases mitochondrial translocation of Drp1 by promoting SUMOylation modification of Drp1 to cause abnormal mitochondrial division of nucleus pulposus cells to play a pathophysiological role, and in-vivo inhibition of MAPL can significantly reverse the degeneration phenotype of intervertebral disc. Compared with the prior art, the invention focuses on the SUMOylation modification effect of MAPL on Drp1, and aims to reveal the molecular mechanism of the MAPL for influencing the IVDD process by regulating mitochondrial division, thereby providing an innovative theoretical basis for developing a precise targeted therapy strategy.

The present invention relates to a method for determining the disc incision depth of posterior lumbar interbody fusion, comprising the following steps: (1) Selecting patients with lumbar degenerative diseases who have undergone X-ray examination and plain CT scan of lumbar intervertebral discs as samples; (2) Removing unqualified samples; (3) Taking anteroposterior and lateral X-rays of the lumbar spine with the patient standing, and performing tomographic scanning with the patient lying flat; (4) Measuring the lengths of the lower edges of the L3 (the third lumbar vertebra), L4 (the fourth lumbar vertebra), and L5 (the fifth lumbar vertebra) vertebral bodies in the X-ray films as the X-ray depths of the L3 / 4, L4 / 5, and L5 / S1 intervertebral spaces; (5) Performing statistical analysis using SPSS 18.0 software and making a table of the analysis results; (6) Obtaining the warning value of the disc incision depth based on the data results. This method provides the warning value of the insertion depth of the nucleus pulposus forceps for medical staff performing posterior lumbar interbody fusion, improving the safety and success rate of interbody fusion.

1. Name of the product in this design: Percutaneous endoscopic discectomy. 2. Purpose of this design: This design is used for observation, diagnosis and adjunctive treatment of spinal parts such as intervertebral foramina and intervertebral discs. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention relates to the technical field of LDH image processing, and provides an image auxiliary recognition method and system for LDH. The method comprises the steps that a lumbar vertebra image and a posture image of a patient are acquired, a human body posture in the posture image is recognized through an artificial intelligence model, the stress condition of the lumbar vertebra under the posture is predicted, stress of all vertebrae in the lumbar vertebra image is positioned, and a positioning result is obtained; according to the method, the stress condition of each intervertebral disc is obtained, and the outline of the intervertebral disc is corrected based on the stress condition of the intervertebral disc, so that the outline change caused by the posture when the patient shoots the image in the intervertebral disc image can be eliminated, a doctor is assisted to identify and analyze the image, and the misjudgment risk is reduced.

Devices and methods for treating joint degeneration (e.g., intervertebral disc degeneration) are provided. An example method may comprise: (1) advancing a tip of an introducer needle into a nucleus pulpous of an intervertebral disc; (2) with the tip of the introducer needle in the nucleus pulpous, maneuvering, out of the tip of the introducer needle, a tip of a flexible needle into a region of a cartilaginous endplate (CEP) of the intervertebral disc; and (3) delivering, from an aperture of the flexible needle, therapeutic to the region of the CEP.

The invention belongs to the technical field of waist support equipment, and discloses an intelligent feedback waist support with a multifunctional physical therapy effect. Low-frequency electrical stimulation modules are mounted on two sides of an arc-shaped waist belt body; the medium-frequency electrical stimulation module is mounted in the middle of the arc-shaped waistband body; vibration modules are mounted on the arc-shaped waistband body between the medium-frequency electrical stimulation module and the low-frequency electrical stimulation modules on the two sides; the myoelectricity biological feedback module is mounted in the middle of the arc-shaped waistband body between the two vibration modules; the controller is electrically connected with the low-frequency electrical stimulation module, the intermediate-frequency electrical stimulation module, the vibration module and the myoelectricity biological feedback module. The purpose of stimulating muscle contraction to stabilize the spine can be achieved; stimulation of erector spinalis muscles, latissimus dorsi muscles and multifidus muscles can be completed, and the purpose of relaxing deep muscles is achieved; massage can be carried out, and the effects of relaxing muscles, reducing intervertebral disc pressure and inducing muscle hypertrophy are achieved; the paravertebral muscle electromyographic signals can be conveniently monitored in real time, and scientific treatment on the waist is achieved.

1. Name of the product in this design: Visual Spinal Electronic Endoscope. 2. Purpose of this design: Primarily used to provide images via a video display for the observation, diagnosis, and treatment of diseases of the human spine and intervertebral discs. 3. The key point of the design of this product lies in its shape. 4. The image or photograph that best illustrates the key design points: Design 1 combined state reference diagram. 5. Designate Design 1 as the base design.

This invention discloses a device for modeling intervertebral disc degeneration in rats, comprising a first barrel, a second barrel disposed on top of the first barrel, and a connecting cylinder disposed between the first and second barrels. An operating port is provided on the outer wall of the connecting cylinder. A restraining collar is fixedly sleeved on the end of the outer wall of the connecting cylinder. Opposite ends of the outer walls of the first and second barrels are slidably sleeved with the restraining collar. A locking component is disposed on the side of the first and second barrels, used to lock the first and second barrels in place. This invention utilizes the cooperative use of the first barrel, second barrel, connecting cylinder, and locking component. Under the action of the locking component, the first barrel, second barrel, and connecting cylinder can be assembled into a whole, and the connecting cylinder can rotate relative to the first and second barrels, thereby changing the position of the operating port on the connecting cylinder corresponding to the fixed rat.

Provided herein are cell-free compositions containing the secretome / exosomes of dsRNA primed cells ("herein dsRNA-primed secretome / exosome). The dsRNA-primed secretome is obtained from conditioned media following cell culture (for an effective amount of time) of cells treated with dsRNA, either by transfecting the cells with dsRNA or incubating the cells with dsRNA. The dsRNA-primed secretome / / exosome can be administered to a subject in need thereof, by administering an effective amount of the dsRNA-primed secretome / exosomes to a subject in need thereof. Exemplary subjects / sites of treatment include subjects include, but are not limited to in need of wound healing such as skin wound healing, burn sites, subjects in need of bone repair such as osteochondral bone repair, bone fracture sites, corneal wound sites. Other subjects include osteoporotic subjects and subjects with intervertebral disc degeneration.

An interbody device (100) for a surgical procedure having an outer body (164) made of a radiopaque material (160) and an insertion portion (116) having a first width at a first end of the insertion portion (116) that is less than a second width at a second end of the insertion portion (116). The insertion portion (116) configured for entering into a disc space (123) and the interbody device (100) including a top surface (124) having a convex shape.

The description relates to an expandable intervertebral spacer configured to engage an intervertebral disk. An example expandable spacer includes a main body, a first endplate, a second endplate, a driving member, a plurality of pins, and an actuation member. The expandable spacer is configured to transition from a first configuration to a second configuration by various structures (e.g., steps, faceted surfaces, curved surfaces, multi-faceted portions) defined on the first endplate, the second endplate, and the driving member.

The utility model relates to the field of medical instruments, and discloses a working cannula for cervical endoscopic surgery, which comprises a cannula main body provided with a through hole, a first opening of the cannula main body is obliquely arranged, one side, close to a second opening of the cannula main body, of the first opening is defined as a first side, and one side, far away from the second opening, of the first opening is defined as a second side; the sleeve main body is provided with a limiting thread above the first opening, and the limiting thread is matched with the limiting ring to adjust and control the working depth of the sleeve main body; the limiting threads are arranged and matched with the limiting ring, so that the movement of the cannula body can be well limited, the depth of the cannula placed in the intervertebral space is controlled and stabilized during operation, the situation that the cannula body is too deep to penetrate the rear wall of the intervertebral disc and damage the spinal cord is avoided, the operation risk is reduced, and related complications of spinal cord injury are reduced.

The invention relates to the technical field of medical instruments, and particularly discloses an intervertebral disc repair stent based on collagen hyaluronic acid gradient bionics and a preparation method of the intervertebral disc repair stent. The invention discloses an intervertebral disc repair stent. The material of the intervertebral disc repair stent comprises collagen and hyaluronic acid, the device is of a cylindrical structure and is formed by sequentially connecting a nucleus pulposus center area, a transition area and a fiber ring area from inside to outside. The nucleus pulposus central area is of an elliptic cylinder structure, and the material composition is constant in content; in the transition area, the content of hyaluronic acid in the material composition is gradually reduced from the innermost side to the outermost side; the fiber ring area is formed by regularly arranging 3-25 concentric bundle sheets, and fibers in the adjacent concentric bundle sheets extend in opposite directions; the collagen content in the material composition is linearly increased from the innermost side to the outermost side. By utilizing the technical scheme provided by the invention, the prepared intervertebral disc repair stent has a bionic structure so as to promote tissue regeneration, and is high in safety and great in clinical application potential.

The invention provides an end-plate inflammation automatic detection and quantitative grading method based on a convolutional neural network, and the method comprises the following steps: S1, marking a lumbar sagittal view MRI image, and making a data set; and S2, the data set is processed based on a YOLOV8 grading model, an intervertebral disc degeneration grading result is obtained, the damage grade of the damaged structure is judged according to a preset grading definition, and the YOLOV8 grading model mainly comprises a Backbone module, a Neck module and a Head module. According to the method, the focus can be independently positioned and graded, and the positioning precision can reach the end plate level.

The application discloses application of a benzimidazolone compound in preparation of a medicine for treating intervertebral disc degeneration. 11 H 14 N4O2, and has a CAS number of 881591-33-9. The application provides an innovative treatment strategy capable of intervening in an early stage of the disease and influencing disease progression from a cause level by targeting activation of SOD1 activity which is a newly found pathogenic link of intervertebral disc degeneration.

A solid-liquid composite multifunctional bionic intervertebral disc belongs to the technical field of bionic intervertebral discs. The upper end plate assembly, core layer and lower end plate assembly of the present invention are arranged in sequence from top to bottom and fixedly connected; the upper end plate assembly and the lower end plate assembly have the same structure, and the end plates are provided with coatings, nail tooth groups and micropore groups; the core layer is composed of a nucleus pulposus, a transition ring and four fibrous rings arranged and fixedly connected from the inside to the outside, and the nucleus pulposus is made of a low-acyl gel and agarose of a liquid core injected into a cellulose sponge of a solid skeleton of a soft support structure; the surfaces of the transition ring and the four fibrous rings are coated with collagen fibers, and the slopes of the collagen fibers of each two layers are staggered with each other; the present invention has cushioning and shock absorption, dynamic anti-fatigue functions, good spinal motion matching and anti-compression and anti-shear mechanical properties.

The application belongs to the technical field of image processing, and provides a fusion processing system for spine MR images and CT images, a segmentation model constructed through a Mamba structure, multi-scale feature extraction realized by using a three-way Mamba module, and the segmentation accuracy of the bony structure of the spine, intervertebral discs and soft tissues is significantly improved by combining gated spatial convolution and feature-level uncertainty estimation; at the same time, the GPU memory consumption is effectively reduced by the cascade training flow design, and under the premise of ensuring the segmentation quality, the generation of high-resolution fusion images is realized; on this basis, the fusion network based on a double-input Mamba structure has global perception ability and linear extraction ability of directional features, can efficiently fuse the high spatial resolution bone structure information of CT and the soft tissue contrast advantage of MRI, ensures the consistency of anatomical structures, fully retains the complementary features between modalities, and significantly improves the comprehensive analysis accuracy of spine images.