115 results about "Dura mater" patented technology

The invention discloses an endoscope transnasal skull base dura mater stitching instrument, and relates to the field of medical instruments, the endoscope transnasal skull base dura mater stitching instrument comprises a stitching instrument main body, an end protection shell, a locking mechanism, an auxiliary mechanism, a connecting rope assembly and a trachea assembly, the locking mechanism comprises a locking sleeve arranged in a first position hole in a sliding mode, and the locking sleeve is of a cylindrical structure with one end open; an elastic body is fixedly arranged on the inner wall of the opening end of the locking sleeve, when the needle sleeve extends into the first position hole, the locking sleeve is controlled to move in the first position hole, and when the elastic body on the locking sleeve is clamped into the annular clamping groove in the outer ring of the needle sleeve, the needle sleeve is fixed to the locking sleeve. According to the invention, the purposes of pulling up the dura mater to facilitate suturing, position adjustment, knotting and degradation during suturing are simultaneously realized, and the defect that a knotting mechanism, a suturing mechanism and an endoscope mechanism cannot be simultaneously placed on a narrow skull base in the prior art is overcome.

The invention discloses a mouse spinal cord flexible electrode and a stimulation parameter optimization method, and relates to the technical field of parameter optimization. The mouse spinal cord flexible electrode comprises a soluble insertion layer, a gradient substrate layer, spinal cord anastomosis ribs, a conductive snakelike net, a hemispherical touch dot matrix, a microfluidic layer, an optical waveguide layer and a top packaging layer; the soluble insertion layer is photo-crosslinked PEG-DMA with the thickness of 5-25 m, the Young modulus is kept within the range of 0.8-1.5 GPa before implantation, and the soluble insertion layer is hydrolyzed in cerebrospinal fluid within 0.5-3 hours after implantation and completely falls off; the spinal cord anastomosis rib comprises an expandable S-shaped folding structure arranged on the upper surface of the gradient substrate layer, the distance between every two adjacent ribs ranges from 80 m to 200 m, the height of the folded state is not larger than 15 m, the height of the unfolded state ranges from 15 m to 40 m, and the spinal cord anastomosis rib is used for forming a cerebro-spinalfluid bypass groove extending in the longitudinal direction of the spinal cord on the surface of the dura mater. According to the invention, the positioning precision, safety and long-term efficiency of mouse spinal cord electrical stimulation can be effectively improved.

The invention discloses a brain-computer interface signal enhancement and evaluation method fusing physical information. The method comprises the following steps: firstly, based on an individual structure magnetic resonance image, constructing a personalized six-layer brain tissue anatomical model comprising a cortex, a white matter, cerebrospinal fluid, a dura mater, a skull and a scalp, and endowing differentiated conductivity parameters; secondly, neuroelectrophysiology priori knowledge such as neurodynamics and white matter anisotropic conduction is converted into a representation rule which can be learned by a neural network; then, the rules are systematically embedded into a physical information neural network in a differentiable physical constraint form, including a cortical neurodynamic equation residual error, a volume conduction equation residual error of each layer and an interlayer interface continuity constraint; and finally, training a network by using the scalp electroencephalogram signals, and jointly outputting high-fidelity intracranial electroencephalogram signals and multi-modal neurophysiological information by minimizing a loss function containing reconstruction and physical constraints. According to the method, the fidelity, the physical rationality and the clinical interpretability of signal enhancement are effectively improved.

The invention relates to a biological glue patch applied to non-invasive repair of dura mater, and relates to the technical field of medical biological materials. The biological glue patch comprises a patch base material, a biological membrane layer is arranged on one side of the patch base material, a hydrophobic membrane layer is arranged on the outer side of the biological membrane layer, a vacuum cavity is formed between the inner side of the biological membrane layer and the side portion of the patch base material, and biological glue is arranged in the vacuum cavity; one side, facing the biological membrane layer, of the patch base material is provided with a stabbing part for stabbing the biological membrane layer and the hydrophobic membrane layer. According to the biological glue patch, repairing of the dura mater is achieved in a glue adhesion mode, pinholes are avoided, the phenomenon of leakage of cerebrospinal fluid is avoided, meanwhile, the biological glue is protected through the biological film layer and the hydrophobic film layer, and the biological glue is prevented from being solidified and adhered in advance; the biological glue is released by arranging the stabbing part, the operation is simple, and the device can be applied to repairing the dural mater injury by a non-invasive single-side dual-channel spine endoscope technology.

The present invention provides an artificial dura mater and a preparation method thereof, and relates to the technical field of medical repair materials. The artificial dura mater is mainly composed of a degradable repair membrane layer and an anti-seepage protective layer composited on the degradable repair membrane layer, wherein: the degradable repair membrane layer is composited by a plurality of fiber-oriented sheets, and the orientation direction of the oriented fibers in the fiber-oriented sheets is consistent. The oriented fibers with the same orientation direction are conducive to the attachment of cells, have high biocompatibility, and have good repair and regeneration effects; at the same time, the patch composited by fiber-oriented sheets with different orientation directions in the present application has better mechanical strength. In addition, the anti-seepage protective layer can play a good anti-seepage role, and can also prevent fibroblasts, muscles, and vascular tissue cells from growing into the artificial dura mater to cause adhesion. Therefore, the artificial dura mater of the present application has the advantages of high biocompatibility, good mechanical strength, and excellent anti-seepage and adhesion performance.

The invention relates to a method for identifying a meningioma infiltrating dura mater and delimiting an infiltrating position boundary based on a multi-photon technology, and belongs to the field of computer vision and biomedical optics. The method comprises the following steps: acquiring endogenous multi-photon optical signals of meningioma tissues and normal dura mater tissues around the meningioma tissues; in a multi-channel mode, high-resolution and high-contrast microstructure imaging of meningioma and normal dura mater tissues around the meningioma is obtained; the method comprises the following steps: acquiring certain quantitative morphological optical diagnosis parameters for identifying epidural tissue infiltration at the periphery of meningioma, and acquiring spectral images of tumors at the infiltration part and peripheral normal epidural tissues in a spectral mode; therefore, the infiltration of peripheral tissues of meningioma can be quantitatively and qualitatively identified in morphology and spectrum. And finally, determining the boundary of the tumor tissue at the infiltration position according to different texture analysis on the multiphoton microscopic images of the tumor tissue at the infiltration position and the surrounding tissue. The method disclosed by the invention is beneficial to quickly and automatically identifying the infiltrated boundary of the peripheral dura mater tissue.

Epidural electrical stimulation (EES) systems and techniques for accessing and locating targeted spinal cord segments are disclosed. In some examples, a method includes providing a first set of electrodes of an EES system at a first set of locations on the dura mater of a spine of a mammal, the first set of locations on the dura mater corresponding to a first muscle group of the mammal; providing a second set of electrodes of the epidural electrical stimulation system at a second set of locations on the dura mater of the spine of the mammal, the second set of locations on the dura mater corresponding to a second muscle group of the mammal; and stimulating the first and second sets of locations on the dura mater by electrically energizing the first and second sets of electrodes, respectively, thereby activating the first and second muscle groups in a coordinated manner.

An apparatus includes an intraosseous appliance formed to have hollow channels open to a proximal extradermal surface of the appliance. Optical emitters and detectors reside within channels of the intraosseous appliance having distal openings in a distal base of the intraosseous appliance, in a lateral surface of the intraosseous appliance, and in an extradermal surface of the intraosseous appliance, so as to establish optical paths between the optical emitters and detectors and, respectively, the dura, bone wall of a bun hole and skin of the subject. Intracerebral and extracerebral electrodes reside within respective channels of the intraosseous appliance having distal openings in the distal base of the intraosseous appliance and in the extradermal surface of the intraosseous appliance, respectively.

The present application belongs to the technical field of medical devices, and relates to medical consumables for treating spinal cord injury, in particular to a double-layer core-shell structure artificial fiber dura mater for spinal cord injury and a preparation method thereof. The double-layer core-shell structure artificial fiber is used to form a film structure, the double-layer core-shell structure artificial fiber is composed of an outer shell structure and an inner core structure, the material of the outer shell structure is composed of PLGA and PEG, the outer shell structure is loaded with NM, the material of the inner core structure is PLA, and the inner core structure is loaded with NT3. The double-layer core-shell structure artificial fiber dura mater provided by the present application has the advantages of reducing spinal cord edema, preventing fiber adhesion, improving the microenvironment, promoting the repair of spinal cord injury, and the like.

The present disclosure relates generally to a device and method for aiding in the repair of a dural tear. According to example embodiments, the device is placed substantially within a dural sac interior to a dural tear. The device provides a shield that prevents the underlying nerve roots (including rootlets) of the spinal cord from intruding into the torn area and prevents them from being injured during the repair procedure. The device also redirects cerebrospinal fluid from the area, which aids the surgeon in viewing the procedure site during suturing and / or repair.

Various embodiments of a spinal shield having a shield body including a plurality of lateral extensions configured to be positioned over an exposed spinal canal for establishing a protective barrier around the contents of the exposed spinal canal are disclosed.

The utility model discloses a spinal cord semi-cutting positioning device with a dura mater protection function, which comprises a semi-cutting positioning structure and a dura mater protection sheet, and is characterized in that the semi-cutting positioning structure comprises a mounting frame, a lifting driving module mounted on the mounting frame and a positioning guide pin mounted below a telescopic rod of the lifting driving module; the lifting driving module drives the positioning guide pin to lift; the dura mater protection sheet is in a lifting hook shape, an inner hook section and an outer arm section integrally connected with the inner hook section are formed, a depressed position of the inner hook section is a marrow containing groove so that the dura mater can be cut open, the dura mater protection sheet enables the inner hook section to stretch into an incision, after the spinal cord is placed in the marrow containing groove, the lifting driving module drives the positioning guide needle to descend, and then the dura mater is cut. The positioning guide needle is inserted into a central shaft of the spinal cord until the positioning guide needle abuts against the marrow containing groove. When the positioning guide needle punctures the spinal cord and the scalpel cuts down along the positioning guide needle, the dura mater can be protected by the dura mater protection sheet.

The present invention provides a dura mater suture device integrated with multiple needles under a spinal endoscope, comprising: at least two suture needles, with suture threads connected thereto, for suturing an incision; a tube portion, internally provided with linkage rods having the same number as that of the suture needles, and the suture needles are connected to the first ends of the linkage rods; a handle portion, internally provided with a driving mechanism connected to the second ends of the linkage rods to drive the linkage rods to enable the suture needles to extend out of or retract into the tube portion. By using this suture device, the operation of multi-needle suturing of the incision can be realized by putting it in once, effectively improving the suturing efficiency and reducing the operation duration. The suture device does not need to be put in and taken out multiple times, which can avoid causing damage to the patient; moreover, only one suture device is consumed to complete the suturing of the required number of needles, so the surgical material cost is lower than that of consuming one suture device for each suture, enabling more patients to afford the treatment.

The invention belongs to the technical field of biomedical engineering and medical instruments, and particularly discloses a tailoring type electroencephalogram collecting electrode and application of a biocompatible flexible material.The tailoring type electroencephalogram collecting electrode comprises an artificial meninx layer made of the biocompatible flexible material; the electrode array is arranged to be micron-sized conductive units distributed on the inner side of the artificial meninx layer in an array mode. The biocompatible flexible material is applied to the electroencephalogram collecting electrode. The artificial meninx made of the biocompatible flexible material directly replaces the dura mater, the resistance barrier of the dura mater to signals is eliminated, the electrode is directly coupled to the surface of the cortex, and the signal-to-noise ratio of high-frequency signals is remarkably increased. And by adopting a biocompatible flexible material, the risk of operative wounds and postoperative complications is reduced. The biocompatible flexible material is matched with the elasticity modulus of the brain tissue and can be adaptively attached along with the deformation of the brain tissue, stable electrode-brain interface contact is maintained for a long time, and impedance fluctuation is reduced.

The utility model relates to a displacement reduction device for a fracture block in a spinal canal. The displacement reduction device comprises a holding part, a first connecting rod, a second connecting rod and a reduction part, the reduction part comprises a correction rod, a reduction rod and an epidural mater protection rod; the middle of the reset rod is an arc bent section, and two ends are linear sections. One surface of the correcting rod is connected with the end part of the second connecting rod; the linear section end part of one end of the resetting rod is connected with the correcting rod; the convex surface of the arc bent section of the reset rod faces the holding part; the end part of the linear section at the other end of the reset rod is connected with the dura mater protection rod; and the dura mater protection rod faces the direction of the holding part. The arc bent section of the reduction rod is more attached to an irregular fracture block, and meanwhile the correction rod can better support and stabilize the fracture block to be reduced in the operation process and prevent the fracture block from deviating and rolling. By arranging the dura mater protection rod on the reduction rod, when the fracture block is reduced, the compression of the spinal cord is directly relieved, the dura mater, the spinal cord and nerves can be prevented from being damaged, and iatrogenic secondary injury to a patient is avoided.

An intracranial pressure measurement device has a first plate abutting a patient's dura mater and displaced from a second plate abutting an endocranial surface of the patient's skull. The displacement of the first plate and second plate during elevated intracranial pressures are indicated visually on the device and visible through, e.g., X-ray imaging. This allows the intracranial pressure to be correlated to the mechanical displacement of the first plate from the second plate.

A method and kit for stopping cerebrospinal fluid (CSF) leakage, comprising penetrating and passing an applicator through dural tissue to access the inner dural space, injecting a fibrinogen-containing solution from the applicator into the dural space, applying a sealing member containing a fibrinogen polymerizing agent to the outer surface of the dural tissue, and forming polymerized fibrinogen or a polymerized fibrin clot by contacting the injected fibrinogen-containing solution with the fibrinogen polymerizing agent.

The application discloses a kind of implanted nerve electrode devices of magnetic control telescopic contact and separation cerebral cortex, belong to brain signal research technical field.It includes: flexible substrate, magnetostrictive deformation substrate, magnetostrictive film, elastic component and electrode;The flexible substrate side is provided with several rectangular grooves arranged in order;Two pieces of the magnetostrictive film are pasted to the two sides of the magnetostrictive deformation substrate, and the magnetostrictive film on one side is used to fix the magnetostrictive deformation substrate in the rectangular groove of the flexible substrate;The electrode is fixed on the magnetostrictive deformation substrate, for collecting electroencephalogram;The elastic component is used to pull the deformed magnetostrictive deformation substrate to restore flat state.The device is fixed under dura mater, and can be bent under the drive of magnetic field, realizes the effective contact of nerve electrode and cerebral cortex, compared with traditional semi-invasive nerve electrode, improves the detection quality and stability of electroencephalogram.

The invention provides an epileptic seizure prediction method, device, equipment and program product, and the method comprises the steps: obtaining a normal electroencephalogram signal baseline of a dura mater of an epileptic in an epileptic non-seizure period, and a personalized feature library, the personalized feature library comprises features of the cerebral dura mater electroencephalogram signals of the epileptic within at least one time period before epileptic seizure; acquiring an electroencephalogram signal of the current dura mater of the epilepsy patient; according to the normal electroencephalogram signal base line, the personalized feature library and the current electroencephalogram signal of the dura mater, predicting whether the epilepsy is about to seizure epilepsy or not; under the condition that the epilepsy is about to seize, a first early warning signal is sent out, and the first early warning signal is used for reminding an epileptic that the epilepsy is about to According to the prediction method, the electroencephalogram characteristics of the patient can be reflected more accurately, the false alarm rate and the missing report rate caused by individual differences are reduced, the accuracy of epileptic seizure prediction is improved, and the robustness of the prediction method is enhanced.

An intracranial pressure measurement device has a first plate abutting a patient's dura mater and displaced from a second plate abutting an endocranial surface of the patient's skull. The displacement of the first plate and second plate during elevated intracranial pressures are indicated visually on the device and visible through, e.g., X-ray imaging. This allows the intracranial pressure to be correlated to the mechanical displacement of the first plate from the second plate.

The invention provides a degradable and anti-adhesion artificially synthesized dura mater (spinal mater) patch and a preparation method thereof. The method is relatively simple in process and relatively high in preparation efficiency, the product has a natural three-dimensional structure similar to collagen, and the obtained patch has a double-layer structure, excellent mechanical properties and biocompatibility, can remarkably promote regeneration of damaged meninx tissues, has anti-adhesion and biodegradable properties, and is easy to store, disinfect and prepare before an operation.

A clip for dural closure can include a base, a first leg extending distally from the base and including a first tip, the first tip including a first plurality of digits, and a second leg extending distally from the base and including a second tip, the second tip including a second plurality of digits. The clip can include a sealant positioned on an underside of the base and configured to provide a fluid seal along at least a portion of a dural opening. The clip is transformable between an open configuration and a closed configuration, wherein the first plurality of digits of the first tip of the first leg are configured to interdigitate with the second plurality of digits of the second tip of the second leg in the closed configuration.

The present disclosure provides a bioresorbable foam closure device for trans-nasally closing an opening in a base of a skull. The closure device comprises a phase-separated polymer. The device includes a stem portion having a proximal end and a distal end, and a head portion at the distal end of the stem portion. The closure device is deformed from a free shape to a constricted shape, inserted through a nasal cavity and into the opening, and released to at least partially revert back to the free shape such that the stem portion fills the opening and the head portion abuts cranium and dura to secure the closure device in position and seal the opening.

The invention discloses a continuous spinal-epidural anesthesia catheter, and relates to the technical field of medical instruments, the continuous spinal-epidural anesthesia catheter comprises a catheter body and a flexible support frame body arranged in the catheter body, the catheter body comprises a head part and a catheter body part; a plurality of bulges are connected between the head part in the circumferential direction of the catheter body and the catheter body part so as to limit the head part extending into the dura mater; the flexible supporting frame body is used for supporting the catheter wall of the catheter body to be contracted and contracted in the radial direction, so that the catheter body can be converted between an expansion state relative to the initial state and a contraction state relative to the initial state; the flexible support frame body comprises a central frame body and a plurality of support frame bodies; the center frame body extends in the length direction of the catheter body, the multiple supporting frame bodies are connected between the center frame body and the catheter body in the circumferential direction of the center frame body and can divide an inner cavity of the catheter body into multiple independent cavities, and each independent cavity is provided with a corresponding medicine outlet. And the liquid medicine output by the head part entering the dura mater and the liquid medicine output by the tube body part are shunted.

The utility model discloses self-rotating constant-eccentricity spinning equipment for preparing a dura mater patch, which comprises a supporting seat, a rotating device is rotatably arranged on the supporting seat, a cavity is formed in the rotating device, a horn-shaped fixer and a horn-shaped sealing rotator which are connected with each other are arranged in the cavity, and the horn-shaped fixer and the horn-shaped sealing rotator are connected with each other. The rotating device drives the trumpet-shaped fixer, the trumpet-shaped sealing rotator, the rotary infusion tube and the eccentric needle head to rotate and is matched with external propelling equipment such as an electric push rod to push an injection needle cylinder to be precisely propelled, so that fibers are sprayed and scattered on a roller collector of sterile gauze in a spiral branch form; and the fibers are easy to intertwine due to spiral scattering, so that an important role is played in improving the mechanical property of the dura mater patch. And meanwhile, a single fiber generates a small branch structure in the eccentric spinning jet process, so that different fibers can be mutually hooked and connected, and the mechanical property of the fiber membrane is further enhanced.

The present invention discloses a posterior lumbar zero-profile fusion system and a method for using the same. The fusion system includes a fusion device and an impactor; the impactor includes a connecting seat, which is detachably connected to the fusion device; at least two inclined locking holes are provided on the front side of the fusion device; the axial height of the connecting seat is more than 1.5 cm; the connecting seat is provided with at least two inclined through-channels, and the outlet end of each channel corresponds to a locking hole; the angle between the channel axis and the connecting seat axis is 30 to 35 degrees. According to the present invention, it is only necessary to retract nerve tissues such as nerve roots and dura mater sacs once, and after the fusion device is placed between vertebrae by the impactor, the connecting seat is not directly removed. In the process of screwing in the locking screw, the locking screw and the screwdriver are completely in the connecting seat and the fusion device, and do not contact the surrounding nerve tissue to avoid damaging the surrounding nerve tissue of the vertebrae. Only one posterior spinal canal incision is required, which can greatly reduce surgical costs, surgical risks, surgical trauma and surgical time.

The application provides a multilayer polymer biomimetic membrane for dura mater repair and a preparation method thereof. The biomimetic membrane comprises a three-layer biomimetic nanofiber composite structure: a cell adhesion inner layer on the side facing the brain tissue, an anti-adhesion outer layer on the side facing the skull, and an intermediate reinforcing layer between the cell adhesion inner layer and the anti-adhesion outer layer. The cell adhesion inner layer is a PCL / chitosan / collagen composite fiber layer, the intermediate reinforcing layer is a PCL / hydroxyapatite composite fiber layer, and the anti-adhesion outer layer is a PCL / polylactic acid-hydroxyacetic acid copolymer (PLGA) layer. The method comprises cell adhesion inner layer preparation, intermediate reinforcing layer preparation, anti-adhesion outer layer preparation, and continuous production processing. The application obtains a multilayer artificial dura mater with strong interlayer bonding, high adhesion, and biomimetic mechanical properties.

The invention discloses an artificial ligamentum flavum complex which comprises an artificial ligament and two fixing seats, and the two ends of the artificial ligament are fixedly connected with the two fixing seats respectively. Screw holes are formed in the two fixing seats, the two fixing seats are fixedly connected with the spine by installing screws into the respective screw holes, and the bone contact surfaces at the bottoms of the two fixing seats are provided with micropore structures. When the artificial ligamentum flavum complex is installed on the spine, the artificial ligamentum flavum complex can replace the cut ligamentum flavum to maintain the mechanical stability of the spine and cover the dura mater to reduce postoperative dura mater scars. Therefore, the artificial ligamentum flavum complex can replace ligamentum flavum removed in the operation, improve the stability of the spine of a patient, reduce postoperative spine instability, protect spinal canal duramater and nerves, reduce scar adhesion and improve the postoperative clinical effect.