19 results about "Dura mater" patented technology

The application provides a dura mater repair material and a preparation method thereof. The preparation method comprises the following steps: mixing absorbable polymer material, collagen and a solvent to obtain a spinning solution, then performing electrostatic spinning to obtain an electrostatic spinning film, and then performing heat crosslinking to obtain the dura mater repair material. The preparation raw materials and the preparation method of the dura mater repair material are designed, the absorbable polymer material and the collagen are used as the raw materials, the electrostatic spinning and the heat crosslinking steps are performed, the dura mater repair material with good mechanical properties and degradability is prepared, meanwhile, the dura mater repair material has good morphology control, can effectively avoid the formation of adhesion, provides mechanical support for the surrounding damaged parts, and prevents the pressure of the sutured part from being too large.

An intracranial pressure measurement device has a first plate abutting a patient's dura mater and displaced from a second plate abutting an endocranial surface of the patient's skull. The displacement of the first plate and second plate during elevated intracranial pressures are indicated visually on the device and visible through, e.g., X-ray imaging. This allows the intracranial pressure to be correlated to the mechanical displacement of the first plate from the second plate.

The utility model discloses self-rotating constant-eccentricity spinning equipment for preparing a dura mater patch, which comprises a supporting seat, a rotating device is rotatably arranged on the supporting seat, a cavity is formed in the rotating device, a horn-shaped fixer and a horn-shaped sealing rotator which are connected with each other are arranged in the cavity, and the horn-shaped fixer and the horn-shaped sealing rotator are connected with each other. The rotating device drives the trumpet-shaped fixer, the trumpet-shaped sealing rotator, the rotary infusion tube and the eccentric needle head to rotate and is matched with external propelling equipment such as an electric push rod to push an injection needle cylinder to be precisely propelled, so that fibers are sprayed and scattered on a roller collector of sterile gauze in a spiral branch form; and the fibers are easy to intertwine due to spiral scattering, so that an important role is played in improving the mechanical property of the dura mater patch. And meanwhile, a single fiber generates a small branch structure in the eccentric spinning jet process, so that different fibers can be mutually hooked and connected, and the mechanical property of the fiber membrane is further enhanced.

The application provides a multilayer polymer biomimetic membrane for dura mater repair and a preparation method thereof. The biomimetic membrane comprises a three-layer biomimetic nanofiber composite structure: a cell adhesion inner layer on the side facing the brain tissue, an anti-adhesion outer layer on the side facing the skull, and an intermediate reinforcing layer between the cell adhesion inner layer and the anti-adhesion outer layer. The cell adhesion inner layer is a PCL / chitosan / collagen composite fiber layer, the intermediate reinforcing layer is a PCL / hydroxyapatite composite fiber layer, and the anti-adhesion outer layer is a PCL / polylactic acid-hydroxyacetic acid copolymer (PLGA) layer. The method comprises cell adhesion inner layer preparation, intermediate reinforcing layer preparation, anti-adhesion outer layer preparation, and continuous production processing. The application obtains a multilayer artificial dura mater with strong interlayer bonding, high adhesion, and biomimetic mechanical properties.

The application belongs to the technical field of biomedical experimental animal model construction, and provides a rat severe spinal cord injury immediate decompression model construction method. The method establishes a standardized surgical procedure, including minimally invasive exposure through the paraspinal muscle gap, precise dura mater incision, warm saline low-pressure lavage debridement, and strict dura mater suture repair. The method realizes immediate and effective reduction of intrathecal pressure, removal of harmful substances in the injury area, and stabilization of the local microenvironment after severe spinal cord injury. The application solves the problems of instability, poor repeatability, and difficulty in simulating the clinical decompression effect caused by the non-standard dura mater incision, uncontrollable lavage, and high risk of secondary injury in the prior art. The model constructed by the method is highly standardized and has strong repeatability, and is suitable for in-depth study of the neuroprotective mechanism of dura mater incision decompression treatment for spinal cord injury.

The application discloses an endoscope transnasal skull base dura mater suturing device, relates to the field of medical devices, and comprises a suturing device main body, an end protection shell, a locking mechanism, an auxiliary mechanism, a connecting rope assembly and a trachea assembly. The locking mechanism comprises a locking sleeve slidingly arranged in a first position hole. The locking sleeve is a cylindrical structure with an open end. An elastic body is fixedly arranged on the inner wall of the open end of the locking sleeve. When the needle sleeve is inserted into the first position hole, the locking sleeve is controlled to move in the first position hole. When the elastic body on the locking sleeve is engaged into the annular clamping groove at the outer circle of the needle sleeve, the needle sleeve is fixed on the locking sleeve. The application simultaneously achieves the purposes of conveniently pulling up the dura mater for suturing, adjusting the position during suturing, knotting and degradation, and solves the defects in the prior art that the knotting mechanism, the suturing mechanism and the endoscope mechanism cannot be simultaneously placed at the narrow skull base.

The utility model relates to medical instrument technical field discloses a kind of clamping position shunt and interventional medical instrument.The utility model includes a kind of clamping position shunt, is conveyed and is disposed in the ventricular system and venous system of patient by conveying system and exports cerebrospinal fluid in the ventricular system of patient to venous system, the dura mater between ventricular system and venous system is equipped with puncture hole, the puncture catheter with puncture needle head is included in conveying process, clamping position shunt is arranged in puncture catheter, the proximal end side wall of puncture needle head is equipped with at least one shunt tube installation slot, clamping position shunt includes the shunt tube body for being disposed in venous system and the distal end part for being disposed in ventricular system.The utility model is improved by clamping position shunt and its conveying system, not only simplifies conveying system structure, so that the operation of conveying system is more convenient, operation risk is lower, and shunt tube can also be provided with protection to puncture catheter.

The utility model relates to the field of medical auxiliary device, concretely relates to a kind of distraction device with nerve root retractor for endoscopy of spine, including pincer distraction component and kirschner wire, the pincer distraction component is equipped with mutually crossed articulated left jaw arm and right jaw arm, and the front end of left jaw arm and right jaw arm is equipped with sleeve and retractor respectively, kirschner wire can be fixed in the vertebral bone mass of patient's spine, and the sleeve of pincer distraction component can be sleeved on kirschner wire and can rotate around kirschner wire.The utility model is fixed and positioned by using kirschner wire fixed in the vertebral bone mass of patient's spine and using sleeve to rotate around kirschner wire moderately, the nerve root and dura mater outside spine are pulled by using retractor hook, and left jaw arm and right jaw arm are crossed articulated and are moderately distracted, so that operation visual field can be more clear, and nerve root around spine can be protected throughout, and operation risk can be reduced.

This invention discloses an epidural anesthesia puncture device for use in pain management departments, relating to the field of epidural anesthesia puncture technology. It includes a puncture needle feeding mechanism, a puncture needle, a feed column anti-reverse assembly, and a puncture stop mechanism. The puncture needle feeding mechanism comprises a frame and a hexagonal hollow feed column. A first sliding sleeve is located on the left side of the frame, and a second sliding sleeve is located on the right side. The hexagonal hollow feed column is laterally slidably connected to the first and second sliding sleeves. The lower right end of the frame is connected to the top of a fixing handle via a mounting plate. A protrusion is connected to the top of the fixing handle. A feed control assembly is installed in the lower right corner of the frame. This epidural anesthesia puncture device for pain management departments employs multiple short-distance punctures, avoiding the risk of excessive puncture due to the inertia of manual puncture by the anesthesiologist. Once the puncture is in place, the hexagonal hollow feed column can be quickly locked, stopping the puncture needle's movement and preventing excessive puncture damage to the dura mater, thus ensuring high safety.

The invention relates to biodegradable bilayer sealants for tissue closure. The sealants of the invention are composed of two layers with different compliances. The layer in immediate contact with the tissue has high compliance. The second layer located immediately above the first sealant layer has low compliance, i.e. the sealant is much stiffer. The burst pressure of the bilayer sealants is enhanced relative to either a single layer elastic sealant or a single layer stiff sealant. The improved sealant compositions herein provide a water-tight seal, can access hard to reach tears, be applied in a dry or wet environment, are low-swelling, and can repair a range of incision or tear sizes. The bilayer sealants are particularly useful for sutureless dural closure or as adjuncts to sutured dural closure. Also provided herein are methods of preparing and using the biodegradable sealant compositions.

The application relates to the field of interventional medical technology, in particular to a percutaneous interventional venous sinus puncture access device. The access device is formed by the mutual cooperation of a balloon catheter, a deflecting catheter and a puncture guide wire, can puncture into the subarachnoid cavity in the cranial cavity on the venous sinus without damaging the brain, break the dura mater and arachnoid, construct a stoma between the pontocerebellar angle pool and the inferior petrosal sinus, and make the cerebrospinal fluid flow from the subarachnoid cavity to the venous sinus, to the jugular vein and to the heart, and participate in blood circulation. The access device can also be used for delivering a shunt, so that the hydrocephalus which can only be effectively treated by operation in the past can be treated by a minimally invasive interventional method, the access device is not used for surgical open operation, the intraoperative trauma is reduced, the operation time is saved, and the possibility of postoperative infection is greatly reduced.

This utility model relates to the field of medical device technology, specifically to a device including a fixed titanium clip. The back of the fixed titanium clip is provided with a medical clamp for holding the clip, and the end of the medical clamp is provided with a slot for restricting the fixed titanium clip. This device adds an auxiliary opening and closing component, into which the end of the medical clamp extends to one end of the auxiliary opening and closing component, fixing the fixed titanium clip to the other end of the auxiliary opening and closing component. This changes the way the medical clamp opens and closes to fix the titanium clip, further improving the practicality of the device.

The invention relates to an implant (1) for treating a defect, in particular for replacing and / or closing, of the dura mater. The implant (1) comprises a layer (2) with recombinant collagen and a fibrous layer (3).

Compositions comprising perforated, unseparated amnion / chorion; perforated, separated amnion; and perforated, separated chorion derived from the placenta and methods of preparing and using those compositions are provided. Perforation of placental tissue before or during processing may allow for one or more benefits such as more efficient removal of blood remnants, retention of wound healing and tissue regeneration components, better handling characteristics, or improved healing capacity. The present invention also includes methods of healing a wound of the skin, eye, nerve, tendon, or dura comprising applying the perforated compositions of the invention to the wound.

A method for preparing and applying a double-sided dura mater sealant capable of regulating fibroblast activity, belonging to the field of medical biomaterials, is disclosed. The double-sided dura mater sealant consists of an A-side facing the dura mater layer and a B-side facing the muscle layer, wherein the A-side facing the dura mater layer comprises a central portion and a peripheral portion. The method includes the following steps: preparing the A-side facing the dura mater layer; preparing the B-side facing the muscle layer; and assembling the double-sided dura mater sealant. This invention possesses the ability to bidirectionally regulate fibroblast activity, both enhancing dura mater fibroblast activity and inhibiting extradura mater fibroblast activity, thus resolving the contradiction in fibroblast activity regulation during dura mater injury repair and extradura mater fibrosis prevention. Simultaneously, it provides reliable cerebrospinal fluid leakage sealing performance, solving the problem of simultaneously achieving dura mater injury repair and extradura mater fibrosis prevention.

The present application relates to a kind of multilayer artificial dura mater patch and its preparation method, it solves the technical problems that current artificial dura mater composite patch poor mechanical property, low biocompatibility, high infection risk and easy to occur adhesion, it is provided with dense layer, porous layer and anti-adhesion layer, dense layer contains chitosan, also contains one or two of bacterial cellulose, polyvinyl alcohol;Porous layer contains hydroxybutyl chitosan, or contains chitosan and fish collagen;Anti-adhesion layer contains polyvinyl alcohol and tannic acid.The present application can be widely used in the preparation field of artificial dura mater patch.

The utility model discloses an easy assembly titanium alloy lamina relates to a lamina for lumbar spinal stenosis spinal decompression, and its purpose is to provide a kind of lamina with lamina repair, bone graft bed amplification, dura mater sac protection function's lamina.The easy assembly titanium alloy lamina includes two symmetrical half lamina, and half lamina includes lamina main part, saddle hook and fixing part, the surface of lamina main part is processed with multiple uniform arrangement micropore, and the side of lamina main part is provided with side plate;The end of saddle hook is connected with side plate, and the front end of saddle hook is provided with fixed hole;Fixing part is arranged in fixed hole, and saddle hook can be buckled on the nail stick in the spine nail stick system, and fixing part is used for fixing saddle hook on nail stick.