11 results about "Biological glue" patented technology

The present application relates to a kind of implantable fixation device and method for mouse spinal cord administration, the device includes: catheter assembly, which includes sleeve, injection inner tube and locking nut, the catheter assembly is used to carry out fixed-point infusion in spinal cord parenchyma by the bone hole opened on vertebral vertebra;Vertebra fixation assembly, which includes two V-shaped supports for clamping and fixing on the two sides of the outer periphery of vertebra;And bonding reinforcement system, which includes the initial solid seal layer formed by adhesive to realize the sealing between bone hole and catheter assembly and the structural holding adhesive resin layer formed by resin to realize the fixation between vertebra fixation subassembly and vertebra.The present application designs special vertebra fixation assembly: V-shaped support, and is combined with "biological glue preliminary adhesion" and "dental cement overall wrapping", and constructs a multi-level, rigid-flexible combined "sandwich fixation" composite fixation system.

The present invention relates primarily to the use of a mixture for reducing dust formation and / or erosion. The invention relates additionally to a method for reducing dust formation and / or erosion and also to a mixture suitable for this purpose.

This invention belongs to the field of oil and gas well reservoir stimulation technology, specifically relating to an emulsion for fracturing fluid suitable for bio-colloid flowback fluids and its preparation method. The fracturing fluid emulsion for bio-colloid flowback fluids, by weight, comprises the following raw material components: 80-100 parts acrylamide, 20-30 parts glycyl alanine, 5-10 parts cyclomethylsiloxane oil-in-water dispersant, 10-20 parts 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 10-20 parts hydroxyethyl methacrylate, 15-30 parts 2-acrylamido-2-methylpropanesulfonic acid, 60-80 parts white oil, 5-10 parts emulsifier, 5-10 parts initiator, and 10-15 parts water. This fracturing fluid emulsion significantly increases the solids content while also improving the performance of the fracturing fluid product, thus exhibiting excellent thickening properties even when formulated with bio-colloid flowback fluids.

This invention relates to a construction method for enhancing the impermeability of cement-soil mixing piles based on biocapsules, comprising the following steps: S1, mixing biocapsules into cement slurry; S2, constructing triaxial mixing piles using a two-stirring-one-spraying process, followed by temperature gradient curing of the pile body after construction; the preparation of the biocapsules includes the following steps: dispersing amino-modified silica microspheres in a urease solution for adsorption, then dispersing the obtained urease-loaded biocapsules in a sodium alginate-polylactic acid-chitosan mixed solution for emulsification, and then adding the resulting suspension dropwise to a calcium ion-containing solution for cross-linking and solidification, thus obtaining the final product. This invention introduces a double-layered biocapsule into the cement slurry, which maintains structural integrity during construction and triggers the controlled release of internal active components such as urease when cracks encounter water, significantly improving the impermeability and self-healing performance of the pile body.

The application provides a developmental growth plate layered scaffold and a preparation method and application thereof, and belongs to the technical field of bone tissue engineering materials. The developmental growth plate layered scaffold provided by the application is divided into three layers, the upper layer is a cartilage cell layer, the middle layer is a blood vessel barrier layer, and the lower layer is a bone formation layer. The blood vessel barrier layer can be used as biological glue to bond the upper layer and the lower layer, so that the composite scaffold structure is stable and is not easy to break; and the upper layer contains bone marrow mesenchymal stem cells (BMSCs), and the middle layer and the lower layer are cell-free. Under the in-vitro chondrogenic induction culture condition, the BMSCs in the upper layer can pass through the middle layer and colonize in the lower layer, and in the process, part of the BMSCs can differentiate into cartilage cells. The middle layer containing thrombospondin 1 (TSP1) has specific intervention effect on cell migration, which is manifested as inhibition of the migration of vascular endothelial cells, but has no effect on the migration of BMSCs.

This invention discloses a method for synthesizing polyethylene glycol (PEG) carboxyl-activated esters. This preparation method utilizes centrifugation, taking advantage of the density difference in the solvent to accelerate the extraction process, thus saving production time. Furthermore, purification via membrane treatment in hydrochloric acid solution improves product purity. The use of hydrochloric acid prevents the degradation of the carboxyl-activated ester in water, while the membrane treatment rapidly removes insoluble substances, ensuring purity while preventing deactivation of the carboxyl-activated ester. Both methods employed are highly adaptable to industrial applications. The re-optimized synthesis and purification steps significantly improve the purity and yield of the PEG carboxyl-activated ester. This method for preparing PEG carboxyl-activated esters is simple, yields high purity and high output, and is easily industrialized. It can be used for drug modification, hydrogel preparation, medical sponges, tissue sealants, bio-adhesives, biological scaffolds, fluorescence imaging, and more.

The application discloses a magnetic resonance visualized therapeutic tumor postoperative immune biological glue, a preparation method and application thereof, and belongs to the technical field of medical materials. The biological glue is formed by crosslinking of composite nanoparticles formed by bovine serum albumin and potassium permanganate and a crosslinking agent, genipin. The magnetic resonance visualized therapeutic tumor postoperative immune biological glue prepared by the application has near-infrared light-induced high-efficiency wound bonding performance and synchronous photothermal-immune anti-tumor effect, and has great potential and bright clinical conversion prospect in terms of solving the problems of complex postoperative wound suture processes, postoperative tumor recurrence and metastasis and the like.

This invention belongs to the field of aquaculture, specifically a growth substrate for oysters and its preparation method, comprising the following raw materials by weight: 30-40 parts chitosan-loaded diatomaceous earth, 45-55 parts shell powder, 1-8 parts tourmaline powder, and 35-45 parts bio-adhesive; the chitosan-loaded diatomaceous earth is prepared by two-step cross-linking of tannic acid-iron coordination coating and genipin, thereby firmly anchoring chitosan molecules to the surface of diatomaceous earth in the form of covalent bonds; the raw materials of this invention use waste shell powder, natural diatomaceous earth, and bio-based adhesives (such as soybean protein adhesive), which not only realizes the high-value recycling of marine aquaculture waste, but also eliminates the environmental risks such as white pollution caused by traditional cement-based or plastic-based substrates; the product can be naturally degraded or recycled and crushed after disposal and re-enter the production cycle.

This invention discloses a thrombus filter that is easy to fix and safely remove, relating to the field of medical device technology. The thrombus filter includes a filter screen made of metal wire and a retrieval hook at its proximal end. After the filter screen is released, both the distal and proximal ends have circumferentially evenly distributed petal-shaped mesh openings, the mesh size of which is smaller than that of the middle section mesh opening, and the mesh openings at both ends are staggered circumferentially. Multiple auxiliary positioning structures are provided at the maximum diameter of the filter screen. These structures include a positioning retaining ring and positioning spikes connected by biodegradable bioadhesive. These provide stable anchoring during initial implantation, and after the bioadhesive degrades, allow the positioning spikes and retaining ring to move relative to each other or separate, achieving minimally invasive removal. This invention balances reliable fixation during initial implantation with operational safety during removal, and also has a more significant thrombus-blocking effect.

This invention relates to a bacterial strain that improves the physical structure of red mud and its application. The strain BRT1 is classified as Staphylococcus epidermidis. Staphylococcus epidermidis The accession number is GDMCC No. 66375, the accession date is May 22, 2025, and the depositary institution is Guangdong Microbial Culture Collection Center. This invention utilizes the BRT1 strain, which efficiently improves the physical structure of red mud, solving the technical problem of poor red mud structure. The BRT1 strain secretes extracellular polymeric substances (EPS) as a bio-cementitious agent, effectively promoting the aggregation of red mud particles and forming stable aggregate structures.