79 results about "Biological glue" patented technology

The invention relates to a biological glue patch applied to non-invasive repair of dura mater, and relates to the technical field of medical biological materials. The biological glue patch comprises a patch base material, a biological membrane layer is arranged on one side of the patch base material, a hydrophobic membrane layer is arranged on the outer side of the biological membrane layer, a vacuum cavity is formed between the inner side of the biological membrane layer and the side portion of the patch base material, and biological glue is arranged in the vacuum cavity; one side, facing the biological membrane layer, of the patch base material is provided with a stabbing part for stabbing the biological membrane layer and the hydrophobic membrane layer. According to the biological glue patch, repairing of the dura mater is achieved in a glue adhesion mode, pinholes are avoided, the phenomenon of leakage of cerebrospinal fluid is avoided, meanwhile, the biological glue is protected through the biological film layer and the hydrophobic film layer, and the biological glue is prevented from being solidified and adhered in advance; the biological glue is released by arranging the stabbing part, the operation is simple, and the device can be applied to repairing the dural mater injury by a non-invasive single-side dual-channel spine endoscope technology.

The invention provides a polyethylene glycol derivative-collagen cartilage repair gel which is characterized by being prepared from the following components in parts by weight: 8 to 12 parts of collagen (namely COL) solution, 0.5 to 2 parts of polydeoxyribonucleotide (namely PDRN), 4 to 8 parts of polyethylene glycol disuccinimide succinate (namely SS-PEG-SS) solution and 0.1 to 0.4 part of tannic acid (namely TA), and particularly discloses a preparation method and application of the polyethylene glycol derivative-collagen cartilage repair gel. In a word, the composite gel and the collagen are subjected to efficient amidation reaction through SS-PEG-SS to form a stable three-dimensional network, so that the structural support of the type I collagen, the tissue repair of PDRN and the anti-inflammatory and anti-oxidation characteristics of tannic acid are successfully integrated; therefore, the composite material has the comprehensive performance of good structural stability, high mechanical strength, good biocompatibility, controllable degradation period, excellent needle passing performance and the like, and shows the wide application prospects of clear repair effect, remarkable component synergistic effect, mature production process, outstanding cost effectiveness and the like.

The invention belongs to the field of biomedical materials, and particularly relates to a self-adhesion composite patch for tooth extraction cavity wound repair and a preparation method thereof. The self-adhesion composite patch comprises a wound filling layer and an adhesion blocking layer, the wound filling layer is located in the middle of the adhesion blocking layer, the wound filling layer is made of a biological sponge material, and the adhesion blocking layer is made of polymer fibers and biological glue. The self-adhesion composite patch has excellent hemostasis, repairing, blocking, biosafety, biodegradability and water absorption, due to the excellent water absorption and biodegradability, the wound filling layer can achieve the excellent hemostasis function under the condition of a small filling amount, and meanwhile, the self-adhesion composite patch has the advantages that the self-adhesion composite patch is good in hemostasis effect and good in barrier effect. Due to the reduction of the wound filling layer and the excellent degradation performance, the self-adhesion composite patch cannot generate adverse effects on wound healing, and secondary operation for taking out the patch is not needed.

A nested valved pipeline comprises an outer pipeline, a pipeline support on the inner wall of the outer pipeline and valve leaflets arranged on the pipeline support, 3-5 main ribs extend from the center of the root of each valve leaflet to the edge of each valve leaflet, secondary branch ribs are distributed among the main ribs, and the main ribs and the secondary branch ribs form reinforcing ribs for net-shaped supporting; the reinforcing ribs are embedded into the valve leaflets and are integrally formed with the valve leaflets; the root of the reinforcing rib extends to the attachment area of the valve leaflet and the pipeline support to form a T-shaped anchoring structure, an annular groove is designed in the edge, close to the root of the valve leaflet, of the pipeline support, the T-shaped anchoring structure of the reinforcing rib is embedded into the groove of the pipeline support, and a gap between the valve leaflet and the pipeline support is filled with biological glue; the pipeline support and the outer pipeline are combined and fixed in a physical and chemical mode. The valve leaflet falling risk is reduced, the fatigue life is prolonged, and the reflux and thrombus risks are reduced; due to the nested design of the outer pipeline and the pipeline support, the connecting difficulty between the valve leaflet and the outer pipeline is reduced, and 3D complex design and batch production of the valve leaflet are conveniently achieved.

The invention provides a biological gel acid liquid system as well as a preparation method and application thereof, and belongs to the technical field of fracturing fluids. The biogel acid liquid system comprises the following components in percentage by mass: 15%-20% of hydrochloric acid, 0.2%-0.8% of biogel, 0.5%-2% of a fluorocarbon discharge aiding agent, 1%-3% of an aldehyde ketone amine condensate corrosion inhibitor, 0.5%-2% of an iron ion stabilizer and the balance of water; wherein the biological glue is a fermentation product of a production strain, and the production strain is sphingomonas sp.WG (sphingomonas sp.WG). Through interaction of the components with specific mass percentage content, the biogel is promoted to form a three-dimensional space network structure in an acid liquid system, so that the acid liquid system has good resistance reduction performance, temperature-resistant stability and low damage performance, and safe, efficient and green carbonate reservoir transformation can be realized.

The invention discloses a self-healing interface binder and a preparation method thereof, and belongs to the technical field of binder preparation. The adhesive is prepared from 90 to 110 parts of water, 8 to 12 parts of absolute ethyl alcohol, 50 to 70 parts of cement, 20 to 30 parts of mineral admixture, 15 to 25 parts of polymerized emulsion, 3 to 7 parts of silane coupling agent, 10 to 15 parts of nano silicon dioxide, 5 to 12 parts of unsaturated amide, 8 to 12 parts of unsaturated acid, 4 to 7 parts of biogel, 5 to 8 parts of thixotropic agent, 3 to 6 parts of dispersing agent and 3 to 6 parts of initiator. The mineral admixture comprises silicon powder and rice hull powder in a mass ratio of 3: 7, the polymerized emulsion is vinyl acetate, the silane coupling agent is KH570, the unsaturated amide is acrylamide, and the unsaturated acid is acrylic acid. According to the interface binder prepared by the preparation method disclosed by the invention, through physical permeation and chemical combination, the bonding strength with concrete can be remarkably improved, and the problems of hollowing and cracking are reduced; in addition, a compact protective layer can be formed on the surface of the interface binder, air and moisture are effectively prevented from invading, and the durability of the concrete is improved.

The invention provides a bamboo joint type umbrella-shaped building structure which comprises a stand column formed by a plurality of supporting rods in a surrounding mode, the stand column can be fixed to a lower body structure or a basic position, and each supporting rod is formed by splicing a plurality of bamboo joint modules; the branch columns are fixed to the stand column and arranged in a radial divergence mode with the stand column as the center to form an umbrella-shaped structure, each branch column is formed by splicing a plurality of bamboo joint modules, a grid is formed between every two adjacent branch columns through reinforcing ribs, and a skylight is arranged in each grid; wherein each bamboo joint module can be independently disassembled and assembled, each bamboo joint module comprises at least one bamboo joint, and splicing joints of every two adjacent bamboo joint modules are connected through mortise and tenon joints or bonded through biological glue. The bamboo joint bionic design is achieved through sectional type bamboo joint module splicing, combination of light weight and high strength is achieved, meanwhile, the mortise and tenon joint or biological glue bonding technology is adopted at the splicing joints, metal connecting pieces are reduced, and integrity is improved.

The invention particularly discloses immunoregulation type bone biological glue as well as a preparation method and application thereof, and relates to the technical field of bone biological glue. The invention provides an immunoregulation type bone biological glue which can regulate polarization, osteogenesis and angiogenic differentiation of macrophages, and further meets the clinical requirements of the bone biological glue for regulating an implant bone surface and interface immune microenvironment and osseointegration.

The invention belongs to the technical field of biological adhesives, and relates to an epoxidized bean dreg modified soybean protein adhesive as well as a preparation method and application thereof. The soybean protein adhesive comprises the following components in parts by weight: 80-120 parts of water, 25-35 parts of soybean meal powder, 10-20 parts of epoxidized soybean dregs, 10-15 parts of a polyamide polyamine-epichlorohydrin resin PAE solution and 1-3 parts of an alkali solution, the epoxidized bean dregs are composed of the following components in parts by weight: 80-120 parts of wet bean dregs, 16-20 parts of epoxy chloropropane, 1-3 parts of aqueous alkali and 300-500 parts of deionized water. Wet bean dregs are subjected to epoxy modification to prepare epoxidized bean dregs, then the epoxidized bean dregs are mixed with PAE resin, soybean meal powder and water, and the soybean protein adhesive with water resistance and bonding strength is prepared. The preparation process is simple, the raw material cost is low, the dependence on a petroleum-based modifier is reduced while the performance of the adhesive is improved, and the preparation method has a wide application prospect.

The present invention provides an amniotic membrane-loaded contact lens, its preparation method, and its application. This invention innovates the bonding method between amniotic membrane and contact lens, replacing the previous method of simply bonding the amniotic membrane and contact lens with medical biological glue. This simplifies the bonding process between amniotic membrane and contact lens, making it suitable for industrial application. It also addresses the issues of traditional sutured amniotic membranes, which suffer from decreased mechanical support, rupture, and uneven coverage over time as they cover the ocular surface. The optimization and selection of materials not only meet the basic requirements of a non-toxic and harmless adhesive, but also take into account biocompatibility and the cornea's requirements for contact lens oxygen permeability. The use of amniotic membranes is more comfortable, eliminating the need for complex surgical procedures and the irritation associated with sutures. The design of using a contact lens as an amniotic membrane support allows amniotic lenses to provide superior support and protection for the covered ocular surface.

The present application relates to a kind of implantable fixation device and method for mouse spinal cord administration, the device includes: catheter assembly, which includes sleeve, injection inner tube and locking nut, the catheter assembly is used to carry out fixed-point infusion in spinal cord parenchyma by the bone hole opened on vertebral vertebra;Vertebra fixation assembly, which includes two V-shaped supports for clamping and fixing on the two sides of the outer periphery of vertebra;And bonding reinforcement system, which includes the initial solid seal layer formed by adhesive to realize the sealing between bone hole and catheter assembly and the structural holding adhesive resin layer formed by resin to realize the fixation between vertebra fixation subassembly and vertebra.The present application designs special vertebra fixation assembly: V-shaped support, and is combined with "biological glue preliminary adhesion" and "dental cement overall wrapping", and constructs a multi-level, rigid-flexible combined "sandwich fixation" composite fixation system.

The application belongs to the technical field of biological adhesives, and particularly relates to a preparation method of a konjac bio-based adhesive and application thereof. The application constructs a high-performance konjac bio-based adhesive through a multi-step aqueous process: firstly, a PVA mother liquor is prepared, high shear is introduced to form a hydrogen bond interpenetrating network with konjac glucomannan, so as to guarantee wettability and early holding force; then, a reversible thixotropic sub-network is constructed by sodium lignosulfonate, tannic acid and kaolin, so as to realize shear thinning and stress buffering; a pre-hydrolyzed silane forms a Si-O-C bridge under weak acid conditions, so as to realize the transition of the interface from physical intercalation to chemical anchoring; a latent crosslinking agent (BTCA / SHP) ensures storage stability, and activates esterification reaction to strengthen the bulk phase when used; silane modified nano-SiO2 forms an inorganic lattice, which cooperates with energy consumption to inhibit cracks; finally, a dense glue line is obtained through vacuum degassing and filtration.

The present invention relates primarily to the use of a mixture for reducing dust formation and / or erosion. The invention relates additionally to a method for reducing dust formation and / or erosion and also to a mixture suitable for this purpose.

A method for rapid biocementation of a material under low moisture conditions includes mixing a cell lysate of a urease-producing microbe with the material and, optionally, a calcium source and / or a carbon source, under initial moisture conditions of less than about 15% by weight to form a cementing composition; incubating the cementing composition for a selected time under pressure conditions of between 0 to 1500 bars to form an incubated mixture; and curing the incubated mixture for hours to weeks.

The present application relates to the technical field of corn starch processing, and particularly relates to an extrusion equipment for producing biological latex by using corn starch, which comprises two fixed rings distributed in an inner and outer sleeve manner in a horizontal plane, two rotating sealing rings distributed in an up-down manner and a feeding channel, the two fixed rings and the two rotating sealing rings form a closed space, and the rotating sealing rings are rotatably arranged on the fixed rings; by adopting the mode that the material guiding ring cooperates with the fixed ring, a plurality of material guiding spaces are formed between the material guiding ring and the fixed ring, then the rotation of the material guiding ring is utilized to make each material guiding space pass the position of the material blocking plate in sequence, the material blocking plate blocks the material in the material guiding space, and the rotation of the material guiding ring is cooperated, so that the arc surface on the material guiding ring extrudes the material, thereby realizing direct and effective extrusion effect on the material, avoiding the problem that the extrusion force of the equipment on the material is insufficient and the compactness of the material is not enough due to the flow of the material, and improving the direct efficiency of the extrusion work on the material.

The invention relates to the technical field of biomass adhesives, and discloses an environment-friendly plate bonding biological glue and a preparation method thereof, the biological glue is prepared from a composite vegetable protein basic raw material, water, alkali, protease, phytic acid and vanillic aldehyde thiosemicarbazone; the vanillin thiosemicarbazone is stable at normal temperature and can release vanillin in situ under a hot pressing condition; the preparation method comprises the following steps: carrying out alkaline denaturation on a composite raw material consisting of soybean meal, flour and peanut powder; then carrying out enzymolysis; and finally adding phytic acid and vanillic aldehyde thiosemicarbazone serving as a latent cross-linking agent. According to the invention, phytic acid and vanillin released in situ form a dual cross-linked network, so that the performance is synergistically improved; and the application of the latent cross-linking agent ensures the long working life. The obtained biological adhesive is free of formaldehyde addition and has excellent environmental protection property, mechanical property and process operability.

The utility model discloses a mucilage glue injector with an endoscope protection function, relates to the technical field of endoscope glue injection, and solves the problem that in the prior art, biological glue remains on an injection needle under an endoscope scene. The endoscope glue injection device comprises a glue injection outer tube used for being arranged in an endoscope injection hole in a sliding and penetrating mode, a glue injection inner tube is arranged in the glue injection outer tube in a sliding mode, the tail end of the glue injection outer tube and the tail end of the glue injection inner tube are both connected with a pushing handle, a connecting ring is arranged at the front end of the glue injection outer tube, the circumferential outer side of the connecting ring is connected with a spring wire framework, and a soft skin is arranged on the spring wire framework. A channel can be provided for the glue injection inner pipe by arranging the glue injection outer pipe, a supporting foundation is provided for installation of the spring wire framework by arranging the connecting ring at the front end of the glue injection outer pipe, the spring wire framework is arranged, and the soft skin is arranged on the spring wire framework, so that the front end opening of the glue injection inner pipe can be contained and protected after glue injection of the glue injection inner pipe; the biological glue adhered to the front port of the glue injection inner tube is prevented from polluting an injection hole or an endoscope lens, the structure is simple, the protection effect is good, and the use reliability is high.

A nested valve conduit comprises an outer conduit, a conduit support on the inner wall of the outer conduit, and a valve leaf set arranged on the conduit support, wherein 3-5 main ribs extend from the center of the root of the valve leaf to the edge of the valve leaf, secondary branch ribs are distributed between the main ribs, and the main ribs and the secondary branch ribs constitute a mesh-shaped supporting reinforcing rib; the reinforcing rib is embedded in the interior of the valve leaf and integrally formed with the valve leaf; the root of the reinforcing rib extends to the attachment area of the valve leaf and the conduit support, forming a T-shaped anchoring structure; an annular groove is designed near the edge of the root of the valve leaf of the conduit support; the T-shaped anchoring structure of the reinforcing rib is embedded in the groove of the conduit support, and the gap between the valve leaf and the conduit support is filled with biological glue; and the conduit support and the outer conduit are combined and fixed through physical and chemical methods. The present application reduces the risk of valve leaf shedding, prolongs the fatigue life, and reduces the risk of regurgitation and thrombosis; the nested design of the outer conduit and the conduit support reduces the connection difficulty between the valve leaf and the outer conduit, facilitating the realization of 3D complex design and mass production of the valve leaf.

The invention relates to the technical field of medical apparatuses and instruments, and discloses a chitosan-based medical biogel and a preparation method thereof.The biogel is prepared by taking chitosan as a base material and a natural macromolecular antibacterial auxiliary and a cross-linking agent as auxiliary materials through mixing and freeze-drying processes, the chitosan can be combined with negative charges on the surfaces of red blood cells to form clots, and the clots can be separated from the medical biogel. According to the medical biogel, chitosan and natural macromolecular antibacterial auxiliaries are added, hemostasis is accelerated, wound healing is accelerated, cross-linking of chitosan and the natural macromolecular antibacterial auxiliaries can be achieved in the follow-up heating and mixing process due to addition of the cross-linking agent, the medical biogel can have higher strength, the dressing can be endowed with broad-spectrum antibacterial performance by means of natural broad-spectrum antibacterial agent ferulic acid, and in addition, the medical biogel can be used for preparing the dressing. The medical biogel has an aerogel structure and can contain a large amount of exudate flowing out of a wound, so that a dry environment can be maintained for the wound surface, and wound surface repair is facilitated.

The invention discloses a drainage tube with a degradable fixed function section on the surface, the drainage tube comprises a drainage tube main body and a biological glue adhesion layer coated on the drainage tube main body, the drainage tube main body comprises a silicone tube body, drainage holes and developing stripes, a tube body inner cavity is formed in the silicone tube body, one type is a groove with four longitudinal lines, and the other type is a groove with four longitudinal lines. The other type is that the drainage holes are provided with a plurality of non-adhesion sections which are arranged on the silicone tube body in a longitudinal and gradient manner, the developing stripes are arranged at the 5cm position of the tail end of the silicone tube body and are barium strips, a trapezoidal adhesion section with the length of 10cm is arranged at the 5cm position of the near end of the silicone tube body, a plurality of groups of micro-grooves are formed in the trapezoidal adhesion section, and the micro-grooves are communicated with the developing stripes. And the trapezoidal adhesion section is coated with the biological glue adhesion layer. Degradation time of the degradable material is advanced or delayed, so that multiple drainage tubes with different fixing days are designed, the degradable material of the drainage tube is exhausted before the drainage tube needs to be pulled out according to different operations, and the drainage tube is conveniently and accurately fixed and pulled out.

The present invention relates mainly to the use of a mixture for reducing dust formation and / or erosion. The invention also relates to a method for reducing dust formation and / or erosion, and to a mixture suitable for this purpose.

To provide an analyzing method for collagen fibers that includes a process of bringing a sample and a fluorescent probe into contact with each other and a process of detecting the fluorescent probe.SOLUTION: There is provided an analyzing method for collagen fibers, which includes a process of bringing a sample and a fluorescent probe into contact with each other and a process of detecting the fluorescent probe. wherein the fluorescent probe is selected from the group of diamino fluorescein-FM (DAF-FM), diamino rhodamine-4M(DAR-4M), diamino fluorescein FM diacetate (DAF-FM DA), diamino rhodamine-4M acetoxymethyl ester (DAR-4M AM), derivatives thereof, and combinations thereof.SELECTED DRAWING: Figure 1

This invention belongs to the field of oil and gas well reservoir stimulation technology, specifically relating to an emulsion for fracturing fluid suitable for bio-colloid flowback fluids and its preparation method. The fracturing fluid emulsion for bio-colloid flowback fluids, by weight, comprises the following raw material components: 80-100 parts acrylamide, 20-30 parts glycyl alanine, 5-10 parts cyclomethylsiloxane oil-in-water dispersant, 10-20 parts 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 10-20 parts hydroxyethyl methacrylate, 15-30 parts 2-acrylamido-2-methylpropanesulfonic acid, 60-80 parts white oil, 5-10 parts emulsifier, 5-10 parts initiator, and 10-15 parts water. This fracturing fluid emulsion significantly increases the solids content while also improving the performance of the fracturing fluid product, thus exhibiting excellent thickening properties even when formulated with bio-colloid flowback fluids.

The utility model relates to the technical field of medical instruments, in particular to a gynecological tumor drug sustained-release stent which comprises a stent body, a drug sustained-release layer, a fixing part and an auxiliary taking-out part. The stent body is of a hollow tubular structure, the upper end and the lower end of the stent body are connected with the fixing component and the auxiliary taking-out component respectively, and the drug sustained-release layer covers the outer surface of the stent body. An arc-shaped groove matched with the top of the uterine cavity in shape is formed in the upper surface of the fixing part, and biological glue is arranged on the surface of the arc-shaped groove; the drug sustained-release layer comprises a polymer carrier and a therapeutic drug located on the polymer carrier; the auxiliary taking-out component comprises a tail wire connected with the bottom of the support body. The drug can be continuously and stably released at the gynecological tumor part, the treatment effect is improved, the side effect is reduced, and the stability of the stent is ensured.

A hybrid medical device that can aid in reconstructive or augmentative surgery of the breast is disclosed. The device can utilize a suitable biological collagen tissue matrix combined with a synthetic material, for example, that can impart a high initial strength to the repair site while permitting proper healing and revitalization of the implanted device.

The invention relates to the technical field of dressing films, and discloses a replaceable dressing film and a processing technology thereof.The processing technology comprises the steps that material preparation and quality inspection are conducted, the output of material preparation and quality inspection serves as the input of base film treatment and biological glue coating, and the output of base film treatment and biological glue coating serves as the input of compounding and forming; the output of compounding and forming is used as the input of sterilization and detection, and the output of sterilization and detection is used as the input of film covering and packaging. According to the replaceable dressing pasting film and the processing technology thereof, a precise micropore array is formed on the three layers of elastic base films, excellent air circulation is achieved, allergy, itching and eczema caused by skin closure are reduced, local oppression is relieved due to the low irritation and the softness of medical silicone gel, and the replaceable dressing pasting film has the advantages of being good in breathability and good in breathability. The die cutting and edge cutting process ensures that the edge of the dressing pasting film is neat, the wearing comfort is enhanced, sterilization treatment and sterile packaging effectively prevent microorganism invasion and cross infection, it is ensured that the product is sterile, and the infection risk is prevented.

The invention discloses biodegradable gel and a method for removing paint on the surfaces of stone cultural relics, and relates to the technical field of stone cultural relic protection. The biodegradable gel comprises the following components in percentage by weight: 30-60% of a bio-based main solvent, 10-30% of a bio-based cosolvent, 5-15% of biogel, 1-10% of a thickening stabilizer and the balance of water, the bio-based main solvent is one or more of methyl lactate, ethyl lactate, propyl lactate and butyl lactate, the bio-based cosolvent is one or more of limonene, terpinene, methyltetrahydrofuran and gamma-valerolactone, and the bio-gum is one or more of xanthan gum, guar gum, carrageenan, locust bean gum and sesbania gum. The thickening stabilizer is one or more of bentonite, kaolin, attapulgite and diatomite. The degradable gel has the advantages of favorable swelling property, biodegradability, no toxicity, safety to the environment and operators, no strong acid substance and capability of preventing the surface of the stone cultural relic from being crisp when in use.

This invention relates to a construction method for enhancing the impermeability of cement-soil mixing piles based on biocapsules, comprising the following steps: S1, mixing biocapsules into cement slurry; S2, constructing triaxial mixing piles using a two-stirring-one-spraying process, followed by temperature gradient curing of the pile body after construction; the preparation of the biocapsules includes the following steps: dispersing amino-modified silica microspheres in a urease solution for adsorption, then dispersing the obtained urease-loaded biocapsules in a sodium alginate-polylactic acid-chitosan mixed solution for emulsification, and then adding the resulting suspension dropwise to a calcium ion-containing solution for cross-linking and solidification, thus obtaining the final product. This invention introduces a double-layered biocapsule into the cement slurry, which maintains structural integrity during construction and triggers the controlled release of internal active components such as urease when cracks encounter water, significantly improving the impermeability and self-healing performance of the pile body.

The invention discloses a low-temperature repair-resistant reinforced anti-cracking additive and a preparation method thereof, and belongs to the technical field of concrete repair materials. The additive is composed of a matrix component, a functional additive and an active repairing component according to the mass ratio of 80: (5-10): (5-10). The matrix component comprises sulphoaluminate cement clinker and composite mineral filler; the functional additives comprise modified nano silicon dioxide, polymer rubber powder, an organic anti-freezing agent and anti-cracking fibers; the active repairing component comprises a microbial capsule type self-repairing material and an internal curing agent, wherein a microbial capsule comprises sporosarcina pasteurii and bacillus urealyticum. Through the synergistic effect of the microbial capsules and the modified nano silicon dioxide, efficient self-repairing of concrete microcracks in a low-temperature freeze-thaw environment is achieved, meanwhile, the early strength, freezing resistance, crack resistance and durability of concrete are remarkably improved, and the concrete is especially suitable for protection and repairing of concrete structures in alpine regions.

The invention relates to the technical field of medical instruments, in particular to a minimally invasive visual umbilical artery and vein puncture navigation system and an operation method. The minimally invasive puncture probe comprises a superfine titanium alloy needle body with the outer diameter of 0.5 mm, the needle body is of a hollow design and can be compatible with a 26G-30G catheter, and a needle tip is integrated with a miniature pressure sensor and used for feeding back the penetration resistance of the blood vessel wall in real time; a medical optical fiber with the diameter of 0.2 mm is embedded in the side wall of the sheathing canal, and the optical fiber is connected with a near-infrared spectrometer, so that the trend and depth of a blood vessel can be displayed in real time, and the positioning error lt can be detected; 0.1 mm; the intelligent fixing device comprises a degradable anchoring clamp with a biological glue coating and a pressure sensing patch, and the pressure sensing patch is used for monitoring the displacement of the catheter and giving an alarm. The puncture probe has the advantages that the puncture probe has the minimum puncture caliber nationwide, the outer diameter of the puncture probe is only 0.5 mm, the puncture probe can be compatible with a 26G-30G catheter, and the puncture probe is a system with the minimum puncture caliber in the field nationwide at present. Compared with the catheter with the minimum of 3.5 F (about 1.17 mm) in the prior art, the risk of vascular injury is remarkably reduced.