205 results about "Biological glue" patented technology

A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component and the clotting and adhesive proteins component are harvested simultaneously from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.

A repair device (10) for affixing a migrating stent graft (30) to the interior surface of a vessel wall (31). The repair device includes tubular graft (11) with a bare or uncovered stent (16) affixed to the proximal end (12). The bare stent includes a plurality of distally pointed barbs (17) for securing the repair device to a vessel wall. A second stent (15) is positioned in the passage (14) of the tubular graft to expand the graft against the interior surface of the migrating stent graft (30). Proximally pointing barbs (20) are affixed to the struts of the second stent and extend through the graft material for securing the repair device to the migrating stent graft. Biological glue (22) and other sealing material (23) can be applied to the tubular graft and/or stents for sealing the repair device against the vessel wall and/or the interior of the migrating stent graft.

A composition and method for enhancing tissue growth, regeneration, and repair includes a Biological Glue formed by extraction of an Extremely Platelet Rich Plasma (EPRP) derived from whole blood, and subsequent activation and clotting. The Biological Glue may be utilized alone to fill defects or may be used as an adhesive agent for other biological and non-biological materials. These materials may include processed thrombus derived from the activation of EPRP. Additionally, the Extremely Platelet Rich Plasma may be impregnated with directly harvested or cultured cells, including stem cells, or other materials, prior to activation, to form a Biological Implant that may be implanted in vivo. A Platelet Factor Enriched Serum (PFS) derived from the activation of the Extremely Platelet Rich Plasma (EPRP) may be added to the cell cultures in preparation of a Biological Implant, in order to provide additional growth factors that speed the development of the cell cultures.

The disclosed is a biodegradable copolymer, an amphiphilic diblock copolymer, composed of a hydrophilic segment and a hydrophobic segment. The hydrophilic segment is an endcapped PEG or derivatives thereof. The hydrophilic segment is a random polymer polymerized of lactone or cyclic C₃-C₆ molecule and lactic acid/glycolic acid. There is no coupling agent between the hydrophilic and hydrophobic segments, and the biodegradable copolymer is formed by one-pot ring-opening polymerization. The biodegradable copolymer can be dissolved in water to form a thermosensitive material having a phase transfer temperature of 25 to 50° C., thereby being applied to biological activity factor delivery, tissue engineering, cell culture and biological glue.

The invention discloses a Chinese herbal medicine health preserving plate and a manufacturing method thereof, wherein the Chinese herbal medicine health preserving plate comprises a composite plate body and an aluminum-plated film layer stuck on the outer surface of the composite plate body; and the composite plate body is formed by sticking health preserving Chinese herbal medicines, wood and plant straws with biological glue. By adopting the Chinese herbal medicine health preserving plate and the manufacturing method thereof, the shortcomings of poor health preserving function, high cost and the like in the prior art can be overcome, and the Chinese herbal medicine health preserving plate has the advantages of good health protection function and low cost.

The invention discloses a preparation method for a chitosan-based biomimetic membrane material with an asymmetric structure, and the preparation method comprises the following steps of dispersing chitosan into acetic acid aqueous solution, adding absolute methanol and acetic anhydride for reacting after the chitosan is completely dissolved, and then, centrifugally removing sediment; dropping in alkaline solidification liquid under stirring condition, and filtering to obtain chitosan microgel; adding the chitosan microgel in glycerin solution, injecting the solution in a mold, and standing and draining water, freeze-drying one part to obtain a chitosan-based porous sponge material, and drying the other part to obtain a chitosan-based dense membrane material; bonding the chitosan-based porous sponge material and the chitosan-based dense membrane material to obtain the chitosan-based biomimetic membrane material with asymmetric structure. The preparation method provided by the invention has the advantages that the preparation technology is simple, the prepared chitosan-based biomimetic membrane material has a porous sponge structure and a dense membrane material structure, the chitosan-based biomimetic membrane material is not curly when encountering water, guiding bone regeneration performance is good, and the chitosan-based biomimetic membrane material is degradable and controllable and can be widely used as a guided bone tissue regeneration membrane material in treatment of the fields such as dental implant, osteoarthritis, bone defect, and the like.

The invention relates to a protein-radical biogum fiberboard and a manufacturing method thereof. As the protein radical biogum fiberboard adopts formaldehyde-free protein radical biogum as an adhesive, the formaldehyde emission is far less than that of board products manufactured by urea-formaldehyde glue or phenolic glue. The advanced manufacturing method ensures that the boards produced have excellent hydrolytic resistance and can effectively avoid phenomenon of delamination or barbotage of the boards.

The invention provides bionic bleeding stopping biological glue with an amino acid sequence of SEQ ID NO:1. The invention also provides a bleeding stopping material which contains a protein with an amino acid sequence of SEQ ID NO:1 and sodium alginate modified by Dopa. The invention provides a product with bleeding stopping performance, and the product is prepared from polypeptide with an amino acid sequence SEQ ID NO:1 and a sodium alginate derivative; and application results show that the protein with the amino acid sequence of SEQ ID NO:1 can be used for improving ultramicrostructures, and in vitro experiments prove that the composite has good bleeding stopping effect.

The invention relates to a biological glue adhesive and a method for making the same. The method comprises the following steps that: water and sodium benzoate are mixed and heated in the proportion of 55-70:1 by weight percentage; after the sodium benzoate is entirely dissolved, alum equal to 0.8-1.2 times the weight of the sodium benzoate is added into the water, and the water is stirred to produce milky solution for standby application; in the proportion of 1:1.6-2.5 by weight percentage, sheepskin glue or bone glue is dissolved in the produced milky solution; starch equal to 1/10-1/4 of the weight of the sheepskin glue or bone glue and the sodium benzoate or sodium diacetate equal to 1/3-1/2 of the weight of the sheepskin glue or bone glue are added into the milky solution; the milky solution is stirred well and then finished products can be obtained. The biological glue adhesive solves the deficiencies that the sheepskin glue or bone glue is high in freezing point, liable to mildew and short in storage time. The biological glue adhesive has low freezing point at about 12 DEG C in summer and at about 5 DEG C in winter, and is high in bonding strength, difficult to mildew, stable in performance, easy to store, nontoxic, harmless and low in cost, which is an environmentally friendly biological adhesive.

The invention aims to provide a clear pulp production process for realizing complete comprehensive utilization and removing three wastes. The method is characterized in that the traditional lagged production process for evaporating black liquor, reclaiming boiler burned alkali, causticizing white liquor, reclaiming lime and discharging the pollution in the pollution treatment of three-level biochemical treatment for middle waste water (three wastes of pulp comprise waste water, waste gas and waste sludge) is eliminated; the plant material is completely used to remove three-waste emission of the pulp and increase five by-products such as lignin biological glue and the like to achieve the good effect on pollution treatment with benefit for treating pollution and making money; and the rubbish-free and zero-emission clear pulp production is realized. Therefore, the pulp enterprise becomes a water-saving large enterprise from a water consuming large enterprise, becomes an environment-friendly large enterprise from a pollution discharging large enterprise, positively and actively treats the pollution from the passive treatment and becomes a comprehensive utilization model from a resource consuming large enterprise.

The invention discloses a tumor chemotherapy drug susceptibility detection chip and a using method thereof. The tumor chemotherapy drug susceptibility detection chip is formed by sealing a shell with a chip microstructure on the inner surface and a bottom carrier, wherein the chip microstructure comprises a nutrient solution perfusion unit, four cell culture units and a biological glue filling unit. According to the tumor chemotherapy drug susceptibility detection chip, multiple cell ingredients in in-vitro tumor tissue can be integrated on one micro chip for co-culture, biological factors generated by multiple cells can be diffused to the whole micro platform, heterocytotropic cells are ensured not to be contacted mutually, and the in-vivo growth microenvironment of the in-vitro tumor cell can be simulated to the maximum extent.

Process for separating proteins fibrinogen, Factor XIII and biological glue from a solubilized plasma fraction and for preparing lyophilised concentrates of said proteins

Summary

The invention is related to a process for separating proteins fibrinogen, Factor XIII and biological glue from a solubilized plasma fraction and for preparing freeze-dried concentrates of said proteins comprising the steps of:

• • chromatographic purification comprising the steps of loading an anion exchanger of weak base type with the said solubilized fraction, previously equilibrated with a buffer of a predetermined ionic strength of an alkaline pH, which allows to retain the biological glue, elution of the biological glue by increasing the ionic strength of the said buffer, and
  • separation of FXIII from fibrinogen by addition to at least one part of the biological glue eluate of at least one chemical agent precipitating the FXIII, and recovery of the resulting purified fibrinogen containing supernatant solution, and
  • diafiltration of the fibrinogen, biological glue and resolubilized FXIII solutions, followed by a freeze-drying of said solutions. It is also related to freeze-dried concentrates of the said proteins capable to be obtained by carrying out the process.

The invention relates to a boxing machine, in particular to an automatic boxing machine for biological capsules. The technical problem to be solved by the invention is to provide the automatic boxingmachine for the biological capsules which can enable workers to be easier and is high in working efficiency. According to the technical scheme, the automatic boxing machine for the biological capsulescomprises a bottom plate, supporting rods and a placing table, wherein the supporting rods are fixedly connected to the two sides of the top of the bottom plate, and the placing table is fixedly connected between the supporting rods. According to the automatic boxing machine, the biological capsules can be automatically pushed into a packaging box through a driving assembly, so that the labor intensity of workers can be greatly reduced, the workers can be easier, the working efficiency can be improved, the packaging box can be clamped through a stabilizing assembly, displacement of the packaging box is avoided, and the biological capsules can be smoothly contained in the packaging box.

The invention relates to gel prepared from chitosan or chitosan derivatives by multi-crosslinking and a preparation method. By multi-crosslinking chitosan or the chitosan derivatives, the elasticity modulus and the viscous modulus of the gel are increased and the swelling degree of the gel is reduced under the condition that the crosslinking degree of the gel is not increased. The elasticity modulus and the viscous modulus of the chitosan gel can be further increased each time one crosslinking is increased in the multi-crosslinking process, and the viscoelastic modulus of the gel can be increased by multi-crosslinking under the condition of equal crosslinking degree. The crosslinking times of the chitosan gel are selected according to characteristics of the viscoelastic modulus of different tissue parts, so that the viscoelastic modulus of the chitosan gel is matched with the related tissue, the histocompatibility of the gel in the tissue can be improved, and the use quantity of a crosslinking agent which is irritant or toxic to a human body can be reduced. The gel is applied to the field of soft tissue in tissue engineering such as tissue filling and repair, joint viscoelasticity replenishers, biological scaffolds, anti-cicatricial, anti-adhesion and biological glue and the like.

The invention relates to a shearing-force increase and filtrate loss reduction agent for drilling fluid and a preparation method thereof. The shearing-force increase and filtrate loss reduction agent for drilling fluid is prepared with a method as follows: cross-linked starch, modified natural fiber and biological glue are subjected to graft copolymerization with comonomer under the action of an initiating agent A, wherein with the weight of the cross-linked starch as a reference, the weight fraction of other raw materials is as follows: biological glue accounts for 10-35%, natural fiber accounts for 10-35%, a basifier accounts for 2-8%, sodium chloroacetate accounts for 1-5%, epoxy chloropropane accounts for 0.5-3%, comonomer account for 20-60%, and the initiating agent accounts for 0.5-2%. The shearing-force increase and filtrate loss reduction agent for the drilling fluid can scientifically adjust apparent viscosity and static shearing force of the drilling fluid, has good filtrate loss reduction performance and shearing-force increase performance and is good in salt-resistant and temperature-resistant effect.

The invention discloses a microbial gelled material and a method for forming magnesite by using the microbial gelled material to glue sand grains. The microbial gelled material consists of basophilic microbial broth and mixed solution, wherein the volume ratio of the basophilic microbial broth and the mixed solution is 1:1, the basophilic microbial broth is Sporosarcina pasteurii broth, and the mixed solution is obtained by mixing equal volumes of urea and aqueous solution of MgCl2.6H2O. The method for forming the magnesite comprises formulating 70-90g sand in two grading of lower than 0.15mm and 0.15-0.30mm according to a Fuhlen densest packing method, placing the sand into a test mold, and alternately injecting the basophilic microbial broth in the microbial gelled material into the test mold from top to bottom by using a peristaltic pump. After continuous injection for 10-15 days, the sand grains in the test mold are glued to form the magnesite. The compressive strength of the magnesite is up to 4.0 MPa.

The invention discloses a preparation method of a cassava starch based biomass formaldehyde-free wood adhesive. The preparation method comprises that cassava starch and polyvinyl alcohol are taken as main raw materials of the formaldehyde-free wood adhesive and then are respectively modified, thus the cassava starch based biomass formaldehyde-free wood adhesive is obtained. The preparation methoddisclosed by the invention has the beneficial effects that: 1, the technical problem that biological glue has poor water resistance, low bonding strength and low solid content of starch glue is solved, and a production method for preparing the formaldehyde-free wood adhesive by taking the cassava starch as a base material is provided; and 2, artificial panel industry and cassava industry with resource superiority in Guangxi province are promoted to be developed and expanded, labour employment of hundreds of thousands of people in urban and rural areas can be solved, and harmonious developmentof national economy and society in China is promoted, thus the preparation method disclosed by the invention has wide application prospect.

The invention discloses a preparation method of a flame-retardant core-board, comprising the following steps of: a first step, preparing a core bar of the core-board; a second step, injecting or infusing a water-based flame-retardant agent solution into the core bar through a secondary vacuumizing/pressurizing flame-retardant agent injection technology; a third step, preparing a block board with the core bar obtained in the second step; a fourth step, performing surface flame-retardant treatment on a veneer; a fifth step, assembling the veneer processed in the fourth step with the block board; a sixth step, compressing the obtained assembly with adhesive, wherein the used adhesive is a biological glue; and performing final trimming and sanding to get the finished product of the core-board. By using the preparation method of the flame-retardant core-board, the flame-retardant performance of the core bar of the block board is improved, the flame-retardant agent is a non-halogen material, and the used adhesive is the biological glue, so that formaldehyde emission is greatly reduced, and the board with very excellent flame-retardant performance and environmental performance can be prepared.

The invention concerns a biological collagen bleeding arresting cotton by making biological collagen as raw material and its preparation process. The production steps are as follows: 1.grinding the bio-collagen into powder with 200-800 meshes 2. mixing the bio-collagen powder with bio-absorbing bleeding arresting cotton in weight ration as 0.5-1.5:9, then packing into the die and pressing 3. placing the compressed module of the bio-collagen bleeding arresting under 120-170 centigrade to make it dry. The bio-collagen bleeding arresting cotton is made by complete absorptive biological protein collagen, having no bacterial endotoxin, no pyrogen, no virus and no side effects. In addition, it can solve in the warm water with the temperature being 35íµ also, and can promote the platelet to form a tampon within 30 seconds to exert arresting the bleeding. The biological protein collagen can induce the growth factor transmigration, promote the regeneration of the injured tissue and accelerate the wound healing. In addition, it can be absorbed by the human body during the wound healing up process.

The invention discloses a pair of brassieres and a making method thereof. The pair of brassieres comprises cup bodies and side straps, which are integrally molded, wherein the cup bodies and the side straps are provided with medical hot-melting biological glue, the medical hot-melting biological glue is provided with air vents, and the pair of brassieres is mainly made by using a shaping process and a gluing process. The pair of brassieres is made of flexible materials and has the natural sense of touch and strong adsorbability; the pair of brassieres only needs to be attached onto breasts without components such as shoulder straps and suspenders, brings free and constraint-free feels and is attractive in appearance; in addition, as the medical hot-melting biological glue is provided with the air vents, a woman does not feel muggy after wearing the pair of brassieres. According to the invention, the medical hot-melting biological glue is used as a bonding material and cannot give rise to skin allergy of a human body.

The invention provides an absorbable anastomosis lock nail and a lock nail holder. The anastomosis lock nail is used for repairing sella or basis cranii cerebral dura mater when treating sella lesion via a nasal transsphenoidal approach in neurosurgery or when used for neuroendoscopic surgery. The absorbable anastomosis lock nail comprises a lock head and a lock cap, the head end of the lock head is a three-rhombohedral-surface structure, a raised stopping portion is arranged on the inner wall of the lock cap, and the lock head penetrates through the stopping portion to be fixedly clamped in the lock cap when locking. The structure of the head end of the nail holder corresponds to the structure of the anastomosis lock nail, and the nail holder is provided with fixing grooves corresponding to the lock head and the lock cap. By the aid of the absorbable anastomosis lock nail, artificial cerebral dura mater or autologous fascia and an incised dura mater residual edge of the skull base of a patient can be completely repaired, various complications including cerebrospinal fluid, intracranial infection and the like which are caused by a present traditional method of filling biological glue and various filling materials into sella and sphenoid sinus are obviously reduced, and simultaneously, death rate caused by the complications is reduced.