56 results about "Biological glue" patented technology

The invention provides a polyethylene glycol derivative-collagen cartilage repair gel which is characterized by being prepared from the following components in parts by weight: 8 to 12 parts of collagen (namely COL) solution, 0.5 to 2 parts of polydeoxyribonucleotide (namely PDRN), 4 to 8 parts of polyethylene glycol disuccinimide succinate (namely SS-PEG-SS) solution and 0.1 to 0.4 part of tannic acid (namely TA), and particularly discloses a preparation method and application of the polyethylene glycol derivative-collagen cartilage repair gel. In a word, the composite gel and the collagen are subjected to efficient amidation reaction through SS-PEG-SS to form a stable three-dimensional network, so that the structural support of the type I collagen, the tissue repair of PDRN and the anti-inflammatory and anti-oxidation characteristics of tannic acid are successfully integrated; therefore, the composite material has the comprehensive performance of good structural stability, high mechanical strength, good biocompatibility, controllable degradation period, excellent needle passing performance and the like, and shows the wide application prospects of clear repair effect, remarkable component synergistic effect, mature production process, outstanding cost effectiveness and the like.

The invention provides a biological gel acid liquid system as well as a preparation method and application thereof, and belongs to the technical field of fracturing fluids. The biogel acid liquid system comprises the following components in percentage by mass: 15%-20% of hydrochloric acid, 0.2%-0.8% of biogel, 0.5%-2% of a fluorocarbon discharge aiding agent, 1%-3% of an aldehyde ketone amine condensate corrosion inhibitor, 0.5%-2% of an iron ion stabilizer and the balance of water; wherein the biological glue is a fermentation product of a production strain, and the production strain is sphingomonas sp.WG (sphingomonas sp.WG). Through interaction of the components with specific mass percentage content, the biogel is promoted to form a three-dimensional space network structure in an acid liquid system, so that the acid liquid system has good resistance reduction performance, temperature-resistant stability and low damage performance, and safe, efficient and green carbonate reservoir transformation can be realized.

The invention particularly discloses immunoregulation type bone biological glue as well as a preparation method and application thereof, and relates to the technical field of bone biological glue. The invention provides an immunoregulation type bone biological glue which can regulate polarization, osteogenesis and angiogenic differentiation of macrophages, and further meets the clinical requirements of the bone biological glue for regulating an implant bone surface and interface immune microenvironment and osseointegration.

The invention belongs to the technical field of biological adhesives, and relates to an epoxidized bean dreg modified soybean protein adhesive as well as a preparation method and application thereof. The soybean protein adhesive comprises the following components in parts by weight: 80-120 parts of water, 25-35 parts of soybean meal powder, 10-20 parts of epoxidized soybean dregs, 10-15 parts of a polyamide polyamine-epichlorohydrin resin PAE solution and 1-3 parts of an alkali solution, the epoxidized bean dregs are composed of the following components in parts by weight: 80-120 parts of wet bean dregs, 16-20 parts of epoxy chloropropane, 1-3 parts of aqueous alkali and 300-500 parts of deionized water. Wet bean dregs are subjected to epoxy modification to prepare epoxidized bean dregs, then the epoxidized bean dregs are mixed with PAE resin, soybean meal powder and water, and the soybean protein adhesive with water resistance and bonding strength is prepared. The preparation process is simple, the raw material cost is low, the dependence on a petroleum-based modifier is reduced while the performance of the adhesive is improved, and the preparation method has a wide application prospect.

The present application relates to a kind of implantable fixation device and method for mouse spinal cord administration, the device includes: catheter assembly, which includes sleeve, injection inner tube and locking nut, the catheter assembly is used to carry out fixed-point infusion in spinal cord parenchyma by the bone hole opened on vertebral vertebra;Vertebra fixation assembly, which includes two V-shaped supports for clamping and fixing on the two sides of the outer periphery of vertebra;And bonding reinforcement system, which includes the initial solid seal layer formed by adhesive to realize the sealing between bone hole and catheter assembly and the structural holding adhesive resin layer formed by resin to realize the fixation between vertebra fixation subassembly and vertebra.The present application designs special vertebra fixation assembly: V-shaped support, and is combined with "biological glue preliminary adhesion" and "dental cement overall wrapping", and constructs a multi-level, rigid-flexible combined "sandwich fixation" composite fixation system.

The application belongs to the technical field of biological adhesives, and particularly relates to a preparation method of a konjac bio-based adhesive and application thereof. The application constructs a high-performance konjac bio-based adhesive through a multi-step aqueous process: firstly, a PVA mother liquor is prepared, high shear is introduced to form a hydrogen bond interpenetrating network with konjac glucomannan, so as to guarantee wettability and early holding force; then, a reversible thixotropic sub-network is constructed by sodium lignosulfonate, tannic acid and kaolin, so as to realize shear thinning and stress buffering; a pre-hydrolyzed silane forms a Si-O-C bridge under weak acid conditions, so as to realize the transition of the interface from physical intercalation to chemical anchoring; a latent crosslinking agent (BTCA / SHP) ensures storage stability, and activates esterification reaction to strengthen the bulk phase when used; silane modified nano-SiO2 forms an inorganic lattice, which cooperates with energy consumption to inhibit cracks; finally, a dense glue line is obtained through vacuum degassing and filtration.

The present invention relates primarily to the use of a mixture for reducing dust formation and / or erosion. The invention relates additionally to a method for reducing dust formation and / or erosion and also to a mixture suitable for this purpose.

A method for rapid biocementation of a material under low moisture conditions includes mixing a cell lysate of a urease-producing microbe with the material and, optionally, a calcium source and / or a carbon source, under initial moisture conditions of less than about 15% by weight to form a cementing composition; incubating the cementing composition for a selected time under pressure conditions of between 0 to 1500 bars to form an incubated mixture; and curing the incubated mixture for hours to weeks.

The present application relates to the technical field of corn starch processing, and particularly relates to an extrusion equipment for producing biological latex by using corn starch, which comprises two fixed rings distributed in an inner and outer sleeve manner in a horizontal plane, two rotating sealing rings distributed in an up-down manner and a feeding channel, the two fixed rings and the two rotating sealing rings form a closed space, and the rotating sealing rings are rotatably arranged on the fixed rings; by adopting the mode that the material guiding ring cooperates with the fixed ring, a plurality of material guiding spaces are formed between the material guiding ring and the fixed ring, then the rotation of the material guiding ring is utilized to make each material guiding space pass the position of the material blocking plate in sequence, the material blocking plate blocks the material in the material guiding space, and the rotation of the material guiding ring is cooperated, so that the arc surface on the material guiding ring extrudes the material, thereby realizing direct and effective extrusion effect on the material, avoiding the problem that the extrusion force of the equipment on the material is insufficient and the compactness of the material is not enough due to the flow of the material, and improving the direct efficiency of the extrusion work on the material.

The invention relates to the technical field of biomass adhesives, and discloses an environment-friendly plate bonding biological glue and a preparation method thereof, the biological glue is prepared from a composite vegetable protein basic raw material, water, alkali, protease, phytic acid and vanillic aldehyde thiosemicarbazone; the vanillin thiosemicarbazone is stable at normal temperature and can release vanillin in situ under a hot pressing condition; the preparation method comprises the following steps: carrying out alkaline denaturation on a composite raw material consisting of soybean meal, flour and peanut powder; then carrying out enzymolysis; and finally adding phytic acid and vanillic aldehyde thiosemicarbazone serving as a latent cross-linking agent. According to the invention, phytic acid and vanillin released in situ form a dual cross-linked network, so that the performance is synergistically improved; and the application of the latent cross-linking agent ensures the long working life. The obtained biological adhesive is free of formaldehyde addition and has excellent environmental protection property, mechanical property and process operability.

A nested valve conduit comprises an outer conduit, a conduit support on the inner wall of the outer conduit, and a valve leaf set arranged on the conduit support, wherein 3-5 main ribs extend from the center of the root of the valve leaf to the edge of the valve leaf, secondary branch ribs are distributed between the main ribs, and the main ribs and the secondary branch ribs constitute a mesh-shaped supporting reinforcing rib; the reinforcing rib is embedded in the interior of the valve leaf and integrally formed with the valve leaf; the root of the reinforcing rib extends to the attachment area of the valve leaf and the conduit support, forming a T-shaped anchoring structure; an annular groove is designed near the edge of the root of the valve leaf of the conduit support; the T-shaped anchoring structure of the reinforcing rib is embedded in the groove of the conduit support, and the gap between the valve leaf and the conduit support is filled with biological glue; and the conduit support and the outer conduit are combined and fixed through physical and chemical methods. The present application reduces the risk of valve leaf shedding, prolongs the fatigue life, and reduces the risk of regurgitation and thrombosis; the nested design of the outer conduit and the conduit support reduces the connection difficulty between the valve leaf and the outer conduit, facilitating the realization of 3D complex design and mass production of the valve leaf.

The invention relates to the technical field of medical apparatuses and instruments, and discloses a chitosan-based medical biogel and a preparation method thereof.The biogel is prepared by taking chitosan as a base material and a natural macromolecular antibacterial auxiliary and a cross-linking agent as auxiliary materials through mixing and freeze-drying processes, the chitosan can be combined with negative charges on the surfaces of red blood cells to form clots, and the clots can be separated from the medical biogel. According to the medical biogel, chitosan and natural macromolecular antibacterial auxiliaries are added, hemostasis is accelerated, wound healing is accelerated, cross-linking of chitosan and the natural macromolecular antibacterial auxiliaries can be achieved in the follow-up heating and mixing process due to addition of the cross-linking agent, the medical biogel can have higher strength, the dressing can be endowed with broad-spectrum antibacterial performance by means of natural broad-spectrum antibacterial agent ferulic acid, and in addition, the medical biogel can be used for preparing the dressing. The medical biogel has an aerogel structure and can contain a large amount of exudate flowing out of a wound, so that a dry environment can be maintained for the wound surface, and wound surface repair is facilitated.

The invention discloses a drainage tube with a degradable fixed function section on the surface, the drainage tube comprises a drainage tube main body and a biological glue adhesion layer coated on the drainage tube main body, the drainage tube main body comprises a silicone tube body, drainage holes and developing stripes, a tube body inner cavity is formed in the silicone tube body, one type is a groove with four longitudinal lines, and the other type is a groove with four longitudinal lines. The other type is that the drainage holes are provided with a plurality of non-adhesion sections which are arranged on the silicone tube body in a longitudinal and gradient manner, the developing stripes are arranged at the 5cm position of the tail end of the silicone tube body and are barium strips, a trapezoidal adhesion section with the length of 10cm is arranged at the 5cm position of the near end of the silicone tube body, a plurality of groups of micro-grooves are formed in the trapezoidal adhesion section, and the micro-grooves are communicated with the developing stripes. And the trapezoidal adhesion section is coated with the biological glue adhesion layer. Degradation time of the degradable material is advanced or delayed, so that multiple drainage tubes with different fixing days are designed, the degradable material of the drainage tube is exhausted before the drainage tube needs to be pulled out according to different operations, and the drainage tube is conveniently and accurately fixed and pulled out.

The present invention relates mainly to the use of a mixture for reducing dust formation and / or erosion. The invention also relates to a method for reducing dust formation and / or erosion, and to a mixture suitable for this purpose.

To provide an analyzing method for collagen fibers that includes a process of bringing a sample and a fluorescent probe into contact with each other and a process of detecting the fluorescent probe.SOLUTION: There is provided an analyzing method for collagen fibers, which includes a process of bringing a sample and a fluorescent probe into contact with each other and a process of detecting the fluorescent probe. wherein the fluorescent probe is selected from the group of diamino fluorescein-FM (DAF-FM), diamino rhodamine-4M(DAR-4M), diamino fluorescein FM diacetate (DAF-FM DA), diamino rhodamine-4M acetoxymethyl ester (DAR-4M AM), derivatives thereof, and combinations thereof.SELECTED DRAWING: Figure 1

This invention belongs to the field of oil and gas well reservoir stimulation technology, specifically relating to an emulsion for fracturing fluid suitable for bio-colloid flowback fluids and its preparation method. The fracturing fluid emulsion for bio-colloid flowback fluids, by weight, comprises the following raw material components: 80-100 parts acrylamide, 20-30 parts glycyl alanine, 5-10 parts cyclomethylsiloxane oil-in-water dispersant, 10-20 parts 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 10-20 parts hydroxyethyl methacrylate, 15-30 parts 2-acrylamido-2-methylpropanesulfonic acid, 60-80 parts white oil, 5-10 parts emulsifier, 5-10 parts initiator, and 10-15 parts water. This fracturing fluid emulsion significantly increases the solids content while also improving the performance of the fracturing fluid product, thus exhibiting excellent thickening properties even when formulated with bio-colloid flowback fluids.

The utility model relates to the technical field of medical instruments, in particular to a gynecological tumor drug sustained-release stent which comprises a stent body, a drug sustained-release layer, a fixing part and an auxiliary taking-out part. The stent body is of a hollow tubular structure, the upper end and the lower end of the stent body are connected with the fixing component and the auxiliary taking-out component respectively, and the drug sustained-release layer covers the outer surface of the stent body. An arc-shaped groove matched with the top of the uterine cavity in shape is formed in the upper surface of the fixing part, and biological glue is arranged on the surface of the arc-shaped groove; the drug sustained-release layer comprises a polymer carrier and a therapeutic drug located on the polymer carrier; the auxiliary taking-out component comprises a tail wire connected with the bottom of the support body. The drug can be continuously and stably released at the gynecological tumor part, the treatment effect is improved, the side effect is reduced, and the stability of the stent is ensured.

The invention relates to the technical field of dressing films, and discloses a replaceable dressing film and a processing technology thereof.The processing technology comprises the steps that material preparation and quality inspection are conducted, the output of material preparation and quality inspection serves as the input of base film treatment and biological glue coating, and the output of base film treatment and biological glue coating serves as the input of compounding and forming; the output of compounding and forming is used as the input of sterilization and detection, and the output of sterilization and detection is used as the input of film covering and packaging. According to the replaceable dressing pasting film and the processing technology thereof, a precise micropore array is formed on the three layers of elastic base films, excellent air circulation is achieved, allergy, itching and eczema caused by skin closure are reduced, local oppression is relieved due to the low irritation and the softness of medical silicone gel, and the replaceable dressing pasting film has the advantages of being good in breathability and good in breathability. The die cutting and edge cutting process ensures that the edge of the dressing pasting film is neat, the wearing comfort is enhanced, sterilization treatment and sterile packaging effectively prevent microorganism invasion and cross infection, it is ensured that the product is sterile, and the infection risk is prevented.

The invention discloses biodegradable gel and a method for removing paint on the surfaces of stone cultural relics, and relates to the technical field of stone cultural relic protection. The biodegradable gel comprises the following components in percentage by weight: 30-60% of a bio-based main solvent, 10-30% of a bio-based cosolvent, 5-15% of biogel, 1-10% of a thickening stabilizer and the balance of water, the bio-based main solvent is one or more of methyl lactate, ethyl lactate, propyl lactate and butyl lactate, the bio-based cosolvent is one or more of limonene, terpinene, methyltetrahydrofuran and gamma-valerolactone, and the bio-gum is one or more of xanthan gum, guar gum, carrageenan, locust bean gum and sesbania gum. The thickening stabilizer is one or more of bentonite, kaolin, attapulgite and diatomite. The degradable gel has the advantages of favorable swelling property, biodegradability, no toxicity, safety to the environment and operators, no strong acid substance and capability of preventing the surface of the stone cultural relic from being crisp when in use.

This invention relates to a construction method for enhancing the impermeability of cement-soil mixing piles based on biocapsules, comprising the following steps: S1, mixing biocapsules into cement slurry; S2, constructing triaxial mixing piles using a two-stirring-one-spraying process, followed by temperature gradient curing of the pile body after construction; the preparation of the biocapsules includes the following steps: dispersing amino-modified silica microspheres in a urease solution for adsorption, then dispersing the obtained urease-loaded biocapsules in a sodium alginate-polylactic acid-chitosan mixed solution for emulsification, and then adding the resulting suspension dropwise to a calcium ion-containing solution for cross-linking and solidification, thus obtaining the final product. This invention introduces a double-layered biocapsule into the cement slurry, which maintains structural integrity during construction and triggers the controlled release of internal active components such as urease when cracks encounter water, significantly improving the impermeability and self-healing performance of the pile body.

The invention discloses a low-temperature repair-resistant reinforced anti-cracking additive and a preparation method thereof, and belongs to the technical field of concrete repair materials. The additive is composed of a matrix component, a functional additive and an active repairing component according to the mass ratio of 80: (5-10): (5-10). The matrix component comprises sulphoaluminate cement clinker and composite mineral filler; the functional additives comprise modified nano silicon dioxide, polymer rubber powder, an organic anti-freezing agent and anti-cracking fibers; the active repairing component comprises a microbial capsule type self-repairing material and an internal curing agent, wherein a microbial capsule comprises sporosarcina pasteurii and bacillus urealyticum. Through the synergistic effect of the microbial capsules and the modified nano silicon dioxide, efficient self-repairing of concrete microcracks in a low-temperature freeze-thaw environment is achieved, meanwhile, the early strength, freezing resistance, crack resistance and durability of concrete are remarkably improved, and the concrete is especially suitable for protection and repairing of concrete structures in alpine regions.

According to the method, the glycerol-ethanol mixture is creatively adopted as the cosolvent, preparation of the lignin with the high sulfonation degree is achieved, and the technical effect is remarkable. Wherein the use amount of the cosolvent is 10-30 wt% of water in the sulfonation reaction, and the content of glycerol in the cosolvent is 60-90 wt%. The inventor accidentally finds that lignin with high sulfonation degree can be obtained by taking a proper amount of glycerol-ethanol mixture as a cosolvent in the preparation process of sulfonated lignin. On the basis, the lignin sulfonate and a cationic auxiliary agent are compounded to obtain the biological adhesive, so that the adhesive performance is improved. Compared with the prior art, the preparation method is simple, easy to operate and low in cost, has automatic continuous preparation conditions and has wide industrial application prospects. In addition, in the sulfonated lignin preparation process, traditional Chinese medicine residues are adopted as raw materials; in preparation of the biological adhesive, traditional Chinese medicine soup is adopted to replace part of water, and the traditional Chinese medicine-based biological adhesive is obtained. The bacteriostasis rate of the traditional Chinese medicine-based biological adhesive on escherichia coli and staphylococcus aureus is greater than 90%, the cytocompatibility is good, and the technical problem that in the prior art, a traditional Chinese medicine patch is prone to causing allergy is solved.

The invention provides a construction method of a spinal cord injury animal model for maintaining the integrity of subarachnoid space, which comprises the following steps: adopting a mammal with spinal cord injury, clamping and closing the opening of the dura mater of the mammal, dripping biological glue in alignment with the clamped and closed position, and suturing after the biological glue becomes frost and the dura mater is adhered together. The invention also provides application of the spinal cord injury animal model for maintaining the integrity of the subarachnoid space in research on motor function, nervous tissue recovery or tissue morphology recovery of animals after spinal cord injury. The application shows that after experimental spinal cord injury is caused, the motion function and histomorphological recovery of a mouse can be improved by tightly suturing the dura mater.

The application provides a developmental growth plate layered scaffold and a preparation method and application thereof, and belongs to the technical field of bone tissue engineering materials. The developmental growth plate layered scaffold provided by the application is divided into three layers, the upper layer is a cartilage cell layer, the middle layer is a blood vessel barrier layer, and the lower layer is a bone formation layer. The blood vessel barrier layer can be used as biological glue to bond the upper layer and the lower layer, so that the composite scaffold structure is stable and is not easy to break; and the upper layer contains bone marrow mesenchymal stem cells (BMSCs), and the middle layer and the lower layer are cell-free. Under the in-vitro chondrogenic induction culture condition, the BMSCs in the upper layer can pass through the middle layer and colonize in the lower layer, and in the process, part of the BMSCs can differentiate into cartilage cells. The middle layer containing thrombospondin 1 (TSP1) has specific intervention effect on cell migration, which is manifested as inhibition of the migration of vascular endothelial cells, but has no effect on the migration of BMSCs.

The invention discloses porous silicon nano biological glue as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The porous silicon nano biological glue comprises a water-based solvent and porous silicon particles uniformly dispersed in the water-based solvent; the intelligent tissue adhesive has the advantages of being good in biocompatibility, high in function integration level, simple and convenient in preparation process and the like, achieves the integrated function of bonding, repairing and monitoring on wounds, and has wide application prospects in the field of wound management as an intelligent tissue adhesive.

A method including navigating a primary stent graft to a landing zone of a vessel, expanding the primary stent graft, navigating an adhesive catheter within the primary stent graft, deploying a secondary stent graft within the primary stent graft such that the adhesive catheter is trapped between the primary and secondary stent grafts, dispensing an adhesive from the adhesive catheter, and bonding the primary stent graft to the secondary stent graft with the adhesive.

The invention relates to a composite suspension stabilizer for well cementation and a preparation method thereof, the suspension stabilizer comprises the following components: biological rubber powder, water, a hydration promoter and a solvent, the hydration promoter is used for promoting the affinity of the biological rubber powder to water; the solvent serves as an initial swelling medium of the biological rubber powder prior to water and is used for promoting uniform dispersion of the biological rubber powder in a system and enabling the biological rubber powder to be swelled to a semi-swelled state at the same time, and a space is reserved for a subsequent swelling reaction of the biological rubber powder and water; the suspension stabilizer can be completely hydrated and dispersed in water within 1-2 minutes to play a suspension role while ensuring various properties, the suspension stability of a prepad fluid system is improved, the formed prepad fluid has the characteristics of low viscosity and high shear, drilling fluid and cement paste can be effectively separated, a stratum can be stably pressed, the construction safety and the well cementation quality in the well cementation process are ensured, and the well cementation efficiency is improved. And the fluidity is good, pouring is convenient, and the prepad fluid processing convenience and production efficiency can be greatly improved.

The invention provides a left atrial appendage occluder and a left atrial appendage occluder operating device, the left atrial appendage occluder comprises an occluder main body, the occluder main body is made of a foam material, and the occluder main body is internally provided with biological mucilage glue so as to be filled in a pore channel of the occluder main body. As the plugging main body is made of foam, the plugging main body is provided with a plurality of pore channels. Under normal conditions, the plugging body is filled with the biological mucilage glue and then plugged into the sheathing canal, and the plugging body is driven by the sheathing canal to enter a specific area of the body of a patient. The plugging main body placed in a specific area can expand when encountering blood and being placed in an area where expansion of the plugging main body is not limited any more, so that the biological mucilage glue can be diffused outwards to the outside of the plugging main body. And after a period of time, the biological mucilage glue is coagulated, so that the plugging main body is coagulated in a predetermined area of the patient to realize plugging.

The invention belongs to the technical field of cell biology, and particularly discloses a marine fish gene editing and mutant screening method which comprises the steps of sgRNA synthesis, Cas9-sgRNA RNP complex preparation, microinjection and mutant screening. The marine fish microinjection needle and the biological glue are used, so that the problem that microinjection of marine fish fertilized eggs is difficult is solved; on the basis, the mutants can be screened through PCR amplification, HRMA analysis and PAGE electrophoresis, so that the screening cost is greatly reduced; in addition, the mutant screening time is shortened from several weeks to several months to about four days, and an efficient and economical novel method is provided for marine fish gene editing and mutant screening.

Methods of forming biocemented gels are disclosed. Exemplary methods include biomineralizing a hydrogel to form a biomineralized hydrogel. The biomineralized hydrogel can be used to form a biomineralized organogel and / or a biocemented aerogel. Various materials formed using the gels are also disclosed.