858 results about "Biosafety" patented technology

The invention discloses a pig farm disease risk attribution method and system based on a knowledge graph. The method comprises the following steps: constructing a pig farm biosafety knowledge graph according to a pig industry biosafety application and a pig industry biosafety field knowledge base; secondly, inputting all pig farm events of the pig farm in N days, risks of the pig farm and risk probabilities; factors of pig farm diseases are searched through the pig farm biosafety knowledge map, and the disease text attribution of the pig farm is given according to constraints such as the contribution degree of pig farm problems. The pig farms with medium and high risks are rectified and predicted according to attributed risk items, and the pig farms with low risks or the pig farms without diseases after early warning can be summarized as excellent management experience. Through analysis and reasoning of the atlas, more logical analysis can be provided for pig farm risk attribution tasks, the pig farms are helped to deeply understand characteristics and prevention and control requirements of various diseases, and a scientific basis is provided for formulating targeted prevention and control strategies.

The invention provides a bio-based adhesive and a preparation method thereof. Inspired by a spider thread structure, biomass adhesive interface enhancement based on a tannic acid adhesion group is combined with construction of a differential phase separation structure by biomass-induced polylipoic acid depolymerization, and a brand new strategy of adhesion-cohesion synergistic enhancement of the adhesive strength of the adhesive is realized. According to the invention, tannic acid and carboxymethyl chitosan are introduced into a lipoic acid-based adhesive, so that the purpose of synergistically enhancing the bonding performance of the adhesive through adhesion-cohesion is achieved, and the defects of weak cohesion, low bonding strength, poor water resistance, poor moisture resistance and the like of the conventional biomass adhesive are overcome. Benefited from a new strategy of adhesion-cohesion synergistic enhancement, the biomass adhesive has good adhesive strength in various environments and materials. In addition, the biomass adhesive also has the characteristics of biological safety, antibacterial and mildew-proof properties and recoverability, so that the product has wider application and potential compared with the previous product, and has a good application prospect.

The invention provides a recombinant XVII type collagen and application thereof, and relates to the technical field of protein engineering. The novel recombinant human XVII type collagen is obtained by optimizing and screening collagen structural domain sequences of the human XVII type collagen and then combining the sequences. The recombinant human XVII type collagen is consistent with the corresponding part of the amino acid sequence of the human XVII type collagen, does not generate immunological rejection when being applied to a human body, and can be widely applied to the industries of surgical medical treatment and medical beauty. In addition, the recombinant human XVII type collagen is high in stability, and the problem of protein degradation in the process of expressing recombinant protein by pichia pastoris can be avoided. In addition, the recombinant human XVII type collagen also has the effects of high biological activity, high biological safety, promotion of cell proliferation and differentiation and promotion of hair growth, and can be applied to the field of cosmetics or medicines as a functional component.

The invention discloses a biosafety laboratory airflow risk monitoring method and device, a medium and a product, and relates to the field of data processing. The method comprises the following steps: acquiring airflow sensor data and facility state data, calculating a restraint integrity index according to the two types of data, performing dynamic time warping matching on a real-time change curve of the index and a preset baseline database, outputting a matching degree, and when the matching degree is lower than a preset threshold value, predicting that an airflow restraint barrier has a fracture risk, positioning a risk source according to the data source causing the abnormal matching degree, taking the source as a release point of a virtual aerosol pollutant, executing fluid dynamic simulation in combination with real-time environment data, generating a three-dimensional space-time diffusion trajectory of the pollutant in a laboratory, and extracting a risk quantitative index; and accurate laboratory airflow risk early warning information is generated based on the quantitative indexes. According to the invention, early warning can be carried out before the risk occurs, and the problem of safety hysteresis in airflow risk monitoring of the biosafety laboratory is relieved.

The invention belongs to the technical field of biological medicines, and particularly relates to hydrogel with photo-thermal multiple antibacterial and hemostatic functions. The multifunctional hydrogel is prepared from epsilon-polylysine (EPL), gallic acid (GA), tannic acid (TA) and ferric trichloride hexahydrate. The polyphenols are obtained through multiple mechanisms such as reaction between the polyphenols and amino groups, metal chelation, pi-pi interaction and electrostatic attraction (as shown in Figure 1). The metal ion and multiple dynamic cross-linking system hydrogel is constructed, the hydrogel with positive charges enriched on the surface can act with blood platelets with negative charges, red blood cell aggregation, blood platelet adhesion and vasoconstriction effects are promoted, and the blood coagulation efficiency is improved. The hydrogel shows excellent antibacterial performance and photo-thermal performance, can prevent infection in the inflammation stage of wound healing, can effectively accelerate wound healing, and has good biological safety.

The invention relates to the technical field of disinfection effect evaluation, and discloses a method for evaluating the virus disinfection effect of virus aerosol. According to the method for evaluating the virus killing effect of the virus aerosol, a real virus is simulated by adopting a pseudovirus, so that the biological safety risk is avoided; through the innovative pseudovirus activity detection method, the experimental operation complexity is greatly reduced, the detection time is shortened, meanwhile, the detection sensitivity is improved, and the method can be applied to the disinfection effect test and evaluation of scientific research and commercial air disinfection equipment (such as ultraviolet disinfection equipment).

The invention relates to paclitaxel ganoderma lucidum spore oil self-nanoemulsion composite particles with ganoderma lucidum spores as a carrier and a preparation method of the paclitaxel ganoderma lucidum spore oil self-nanoemulsion composite particles, and belongs to the technical field of medicines. Pretreated Ganoderma lucidum spores (GLS) are obtained through process screening and serve as a drug carrier, and paclitaxel-loaded Ganoderma lucidum spore oil self-nanoemulsion (PGS) is loaded into the Ganoderma lucidum spores (GLS) to obtain paclitaxel-loaded composite particles (PGS (at) GLS). An in-vitro release curve shows that the PGS-atGLS has the characteristic of slow release after reaching the intestinal tract; in-vivo pharmacodynamic experiments show that PGS-atGLS can significantly inhibit development and metastasis of mouse colorectal cancer; tumor tissue slice immunofluorescence analysis shows that PGS-atGLS can effectively play a role in treating colon cancer. The paclitaxel self-nanoemulsion-loaded ganoderma lucidum spore composite particles synergistically promote cancer immune circulation by inducing immunogen cell death and immunoregulation, significantly improve the treatment effect of colon cancer, and have good biological safety.

The invention discloses methotrexate-loaded sulfonated bacterial cellulose / chitosan hydrogel for treating psoriasis and a preparation method of the methotrexate-loaded sulfonated bacterial cellulose / chitosan hydrogel. The method comprises the following steps: firstly, loading methotrexate by using sulfonated bacterial cellulose, and then coupling with chitosan to form the methotrexate-loaded sulfonated bacterial cellulose / chitosan hydrogel. The synthesis method is simple, the prepared methotrexate-loaded sulfonated bacterial cellulose / chitosan hydrogel can promote the transdermal release effect of methotrexate and control the release speed of methotrexate, skin inflammation caused by psoriasis is continuously and effectively relieved, and the methotrexate-loaded sulfonated bacterial cellulose / chitosan hydrogel has good biological safety.

The invention provides a novel PVC (polyvinyl chloride) functional aid for inhibiting release of toxic plasticizers as well as a preparation method and application of the novel PVC functional aid, and relates to the technical field of PVC functional aids. The preparation method of the PVC functional auxiliary agent comprises the steps of co-precipitation of a precursor solution and a modifier solution, crystallization, drying and the like, and the PVC functional auxiliary agent based on the layered double hydroxide structure is finally obtained. The PVC functional auxiliary agent effectively inhibits migration of harmful substances in PVC through surface adsorption and the space resistance effect of nanoparticles, the volatility resistance and migration resistance of a PVC film are remarkably improved, potential threats of PVC products to the environment and human health are reduced, and an effective scheme is provided for improving the biological safety of PVC. According to the invention, the sustainable development and safe application of the PVC material are assisted, and the PVC industry is promoted to transform towards greenization and high performance.

The invention relates to the field of medical instruments, in particular to a heart valve. The invention provides a heart valve. The heart valve comprises a stent body, a skirt edge and developing points. The skirt edge is connected to the bracket body; the skirt edge comprises an inner skirt edge and an outer skirt edge; the inner skirt edge and the outer skirt edge form an interlayer; the developing points are arranged in the interlayer; the number of the developing points is at least two; at least two developing points are in the same or different annular cross sections. Developing points are arranged in an interlayer; the setting mode can physically isolate the developing point, and the direct contact between the bracket and the developing point is eliminated through physical isolation; the galvanic corrosion risk can be effectively avoided, and the service life of instruments is prolonged; the metal ion release risk is reduced, and the biological safety is improved. And the developing points are arranged in the interlayer between the inner skirt edge and the outer skirt edge, so that the overall position of the valve can be reflected more accurately.

The invention discloses a combined type air conditioner purification system for a biosafety laboratory, and belongs to the field of air conditioner purification systems.The combined type air conditioner purification system comprises an air treatment unit, a pressure gradient maintaining unit and a comprehensive control unit.The air treatment unit comprises a filtering module, a temperature treatment module and a humidity treatment module; the filtering module is used for filtering particle impurities, dust and pollen in air and removing microorganisms in the air, the temperature processing module is used for increasing or reducing the air temperature, the humidity processing module is used for increasing or reducing the air humidity, and the pressure gradient maintaining unit is composed of an air feeder and a return fan. The air feeder is used for feeding air into the area, and the return fan is used for pumping back and discharging the air in the area. According to the invention, micro pollutants such as microorganisms can be effectively removed, and self-adaptive adjustment can be carried out according to environmental conditions in different areas.

The invention provides a nanoparticle capable of releasing EGCG (epigallocatechin gallate) in response to ROS (reactive oxygen species) as well as a preparation method and application of the nanoparticle. The nanoparticles comprise a carrier and EGCG (epigallocatechin gallate) loaded on the carrier; the carrier is Prussian blue nanoparticles of which the surfaces are modified with polyethyleneimine and phenylboronic acid compounds. The preparation method of the nanoparticles is simple and easy to operate, the nanoparticles are good in dispersity, and through research, the nanoparticles have CAT-like, SOD-like and other multi-enzyme activities, can remove. OH, have a high EGCG drug loading rate and release EGCG in the presence of ROS. Besides, the nanoparticles show a good effect of improving myocardial ischemia reperfusion injury in cell level and rat in-vivo experiments, through comparison of EGCG and PB NPs single-drug treatment, synergistic treatment in the composite material achieves an effect of '1 + 1 > 2', and the composite material has good biological safety.

The invention discloses an antibiotic slow-release system based on hierarchical porous silicon dioxide and a preparation method of the antibiotic slow-release system, and belongs to the technical field of biological medicines. The antibiotic slow-release system comprises a spherical hierarchical-pore silicon dioxide microsphere carrier, amino functional groups covalently bonded to the outer surface and the inner surface of a pore channel of the spherical hierarchical-pore silicon dioxide microsphere carrier, antibiotic molecules loaded in the pore channel of the spherical hierarchical-pore silicon dioxide microsphere carrier, and a pH-responsive chitosan gating layer. The preparation method comprises the following steps: (1) preparing a hierarchical pore silicon dioxide microsphere carrier; (2) aminating the surface of the carrier; (3) loading antibiotics; and (4) constructing the pH responsive chitosan gating layer. According to the invention, the silicon dioxide carrier with a macroporous-mesoporous hierarchical structure is constructed to realize high drug loading capacity, and the pH-responsive chitosan gating layer is covalently bonded at the orifice of the silicon dioxide carrier to realize intelligent controlled release, so that the problem that high drug loading capacity, low burst release rate and biological safety are difficult to achieve at the same time in the prior art is solved.

The invention belongs to the field of medicines, and discloses application of pyroglutamic acid in preparation of products for inhibiting fat deposition. The invention has the following advantages: 1, obesity induced by high fat diet is prevented; 2, pyroglutamic acid is a natural amino acid derivative, widely exists in animal and plant bodies, and has good biological safety; meanwhile, the invention further discloses a product for inhibiting fat deposition.

The invention relates to the technical field of nano materials and biological medicines, in particular to black phosphorus-loaded monatomic nano enzyme as well as a preparation method and application thereof. According to the monatomic nano-enzyme loaded with the black phosphorus, the monatomic nano-enzyme loaded with the black phosphorus takes a black phosphorus nanosheet as a carrier, and a metal simple substance is anchored on the surface of the carrier; wherein the metal elementary substance comprises any one of iron, cobalt and manganese. A metal active center is anchored on a black phosphorus nano-carrier, the catalytic activity of monatomic nano-enzyme and the photo-thermal conversion performance of a black phosphorus nano-material are effectively combined, the anti-tumor effect is jointly enhanced through chemical kinetic catalysis and photo-thermal, in addition, a loaded black phosphorus degradation product is mainly phosphate and has biological safety, and the application prospect is broad. The toxicity problem of the traditional nano-enzyme can be solved; the wide application is facilitated.

The invention relates to the technical field of biology, and particularly provides a targeting carrier, a targeting drug, a preparation method and application. The targeting carrier comprises (a) a metal-polyphenol compound particle and (b) a targeting structure, and the targeting structure is connected with the outer surface of the metal-polyphenol compound particle. Under the condition that the effectiveness of the LNP based on the cationic lipid and / or the ionizable lipid is not lower than that of the LNP based on the cationic lipid and / or the ionizable lipid, the targeting carrier provided by the invention does not use the cationic lipid and the ionizable lipid, so that the toxicity is greatly reduced, the biological safety is remarkably improved, negative charge drugs are more favorably carried in a living body, the application range is wide, and the targeting carrier can be used for drugs with different sizes. The targeted drug can achieve high expression quantity of nucleic acid drugs, the biological safety is remarkably improved, the targeting property is good, and efficient treatment of various diseases can be achieved.

The invention discloses a composite medical suture and a preparation method thereof, and belongs to the field of biomedicine. In order to solve the problems that an existing medical suture is poor in antibacterial effect and biological safety, the composite medical suture comprises a core layer, a degradation regulation and control layer, a slow release layer and an antibacterial layer which are sequentially arranged from inside to outside; the core layer is prepared from a blend fiber of poly (hydroxybutyrate-hydroxyvalerate) and polycaprolactone-co-polyglycolide; the degradation regulation and control layer comprises a mixture of at least two kinds of polyethylene glycol with different molecular weights; the slow release layer comprises quaternary ammonium salt loaded graphene oxide nanofibers; the antibacterial layer comprises titanium dioxide loaded with silver nanoparticles. Through the synergistic effect of the four layers, the comprehensive optimization of mechanical properties, degradation rate, drug sustained release and antibacterial function is realized; the purposes of improving the slow-release antibacterial performance, reducing damage to the human body, reducing inflammation and the like are achieved, and the antibacterial and degradation effects meet the recovery requirements.

The invention provides a preparation method and application of a turmeric extracellular vesicle targeted drug delivery system with an anti-colon cancer effect. The engineering system of modifying CELNs and loading DOX by the TCP-1 colon cancer targeting peptide is constructed by extracting curcuma longa extracellular vesicles (CELNs). The system of loading adriamycin through targeted modified turmeric extracellular vesicles has better anti-tumor activity and tumor targeting property, and HE staining and serum detection results show that the system has no significant influence on important tissues, visceral organs and liver functions of mice. And the biological safety is improved while a better treatment effect is achieved.

The invention discloses an intelligent scheduling and resource management system for a microbiological detection laboratory, and relates to the technical field of intelligent management, and the system comprises a resource distribution module which carries out the space-time resource distribution of biological safety constraints through a quantum computing adaptive modeling method, generates a task scheduling optimization problem, carries out the optimal solution search through a quantum annealing algorithm, and carries out the optimization of the optimal solution; obtaining a reference resource scheduling scheme; the scheduling module is used for analyzing through a preset public health risk monitoring threshold value, and adjusting resource application and allocation by utilizing a dynamic resource recombination algorithm to obtain a resource scheduling instruction; the collaboration module is used for predicting a laboratory reagent consumption trend by adopting a metabonomics data analysis method, constructing a cross-laboratory emergency resource sharing path through a GAN network and outputting an emergency resource sharing scheme; according to the method, the biosecurity isolation rule is converted into the quantum bit coupling relation through quantum computing adaptive modeling, and the resource scheduling efficiency and the instrument utilization rate of high-grade experiments are improved.

The invention discloses a self-assembled polypeptide nano-enzyme and application thereof, the self-assembled polypeptide nano-enzyme comprises a polypeptide scaffold, a polypeptide sequence with targeting and nano-enzyme affinity, a main body with amino acid having a characteristic sequence derived from natural enzyme and a functional motif containing hydrophobic peptide, the polypeptide nanoparticles are self-assembled by utilizing the hydrophobic interaction of amino acids; the nano enzyme is in coordination binding with the central coordination amino acid; and the targeting peptide is positioned at the N end of the polypeptide sequence and is displayed on the outer layer surface of the self-assembled polypeptide nanoparticle. According to the invention, the high-activity nano-enzyme is biomimetically designed by simulating a natural enzyme metal ion active site and a spatial structure of a catalytic microenvironment. The novel polypeptide nano-enzyme with targeting property and biosafety is constructed by taking polypeptide as a synthesis template. The self-assembled polypeptide nano-enzyme can be administrated through aerosol inhalation, targeted positioning of the nano-enzyme on a focus is guided, ROS of focus tissue is regulated and controlled, and occurrence and development of diseases are inhibited.

The invention discloses preparation and application of a core-shell structure carbon-coated copper nano-antibacterial agent with a slow release function, and relates to the technical field of antibacterial nano-metal materials, and the preparation method comprises the following steps: preparing by using a plasma arc method, taking pure copper as an anode, selecting a graphite rod as a cathode, and after the vacuum degree of an electric arc furnace reaches 10 <-4 > Pa or above, carrying out ultrasonic treatment; the method comprises the following steps: injecting a carbon source into a high-vacuum cavity, purifying in argon, collecting black powder consisting of nano-particles, carrying out a carbon shell burning process on the collected nano-particles, cooling, and recovering. The prepared carbon-coated copper nano-particles are of a core-shell structure with copper as a core and porous carbon as a shell, the porous carbon shell protects the nano-copper particles from being oxidized easily, the high activity of the nano-copper is kept, the nano-copper can achieve efficient and broad-spectrum sterilization at low concentration, meanwhile, slow release of the copper is achieved, and it is guaranteed that the antibacterial agent is higher in biological safety and environment friendliness.

The invention discloses a double-selenium lipid nanoparticle as well as a preparation method and application thereof. According to the nanoparticle, a skeleton is composed of cationic lipid, neutral phospholipid, cholesterol and functionalized PEG lipid, meanwhile, mRNA and a TLR agonist for coding therapeutic protein are carried, and the nanoparticle is synthesized through an ethanol injection method; the nanoparticle has both active targeting and strong transfection capabilities, the lipid nanoparticle is actively targeted to a tumor microenvironment and is taken by tumor cells by using biotin modified PEG lipid, and rapid'inclusion-lysosome 'escape is realized in the tumor cells by using trifluorogroup modified PEG lipid. Meanwhile, the nanoparticles are degraded in a glutathione / hydrogen peroxide dual-mode, so that the entrapped medicine is quickly and effectively released; the drug delivery system provided by the invention is simple in synthesis method, high in gene transfection efficiency and good in biological safety, and has potential value in anti-tumor research and clinical application.

The invention discloses an application of harmine or a pharmaceutical salt thereof in preparation of an antiviral drug. The drug micromolecule harmine hydrochloride screened from a natural product library can significantly inhibit cracking and replication of KSHV, the application of harmine in KSHV virus resistance is reported for the first time, the effective drug concentration is low, high biosafety is achieved, and a new solution is provided for KSHV treatment.

The invention relates to a pH-responsive copper hydrogen phosphate-loaded hydrogel with multiple enzyme-like activities and a preparation method and application thereof. The material mainly shows catalase-like activity in a neutral microenvironment, and can remove H2O2 and relieve oxidative stress; in a weakly acidic microenvironment, the compound mainly shows peroxidase-like activity and catalyzes H2O2 to generate. OH bacteria with higher toxicity; meanwhile, the inherent osteogenesis promoting performance of copper synergistically enhances bone regeneration, the biocompatibility, the oxidation resistance, the osteogenesis promoting capacity under the oxidative stress condition and the antibacterial efficiency under the weak acid condition of the SA / CuHP hydrogel are evaluated through in-vitro experiments, and a type II diabetes rat periodontitis model is established; the in-vivo antibacterial and osteogenesis promoting effects and the biological safety performance of the compound are verified, and a new strategy is provided for treatment of periodontitis with diabetes mellitus.

The invention provides antibacterial silk fibroin hydrogel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The antibacterial silk fibroin hydrogel provided by the invention is prepared from the following components: modified silk fibroin and copper montmorillonite, the modified silk fibroin is at least one of glycidyl methacrylate modified silk fibroin, methacrylic anhydride modified silk fibroin, isocyanate ethyl methacrylate modified silk fibroin and norbornene anhydride modified silk fibroin, and chemical crosslinking is formed among molecules of the modified silk fibroin. The copper montmorillonite and the modified silk fibroin form physical crosslinking through hydrogen bonds, and the mass ratio of the modified silk fibroin to the copper montmorillonite is 100: (1-10). The antibacterial silk fibroin hydrogel provided by the invention has good biological safety, long-acting antibacterial property, electrical conductivity and good mechanical property.

The invention provides a mineralized collagen cartilage repair scaffold and a preparation method and application thereof, and relates to the technical field of biomedical materials.The preparation method comprises the steps that a collagen solution subjected to mineralization treatment is injected into a mold, and a mineralized collagen layer is obtained through deep freezing and primary freeze drying; taking the mineralized collagen layer as a bottom layer, injecting a collagen solution which is not mineralized, and performing deep freezing and first freeze drying to obtain a freeze-dried scaffold; and carrying out crosslinking and secondary freeze drying on the freeze-dried scaffold, and compressing to obtain the mineralized collagen cartilage repair scaffold. A necessary bioactive interface, a continuous interpenetrating structure of a collagenous fiber network and cross-linking treatment are provided for osseointegration, and interlayer separation is avoided; bidirectional regeneration of osteochondral bone is realized, and complexity and risk of clinical application are reduced; in a wet state, good tailorability and enough stiffness are achieved, and meanwhile stable mechanical support is provided; the technical problem that in the prior art, a stent material is insufficient in systematicness of biosecurity of multi-scale structure bionics and interface bonding agents is solved.

The invention relates to an ROS response type persulfide biomacromolecule nano prodrug, a nano preparation and a preparation method and application of the ROS response type persulfide biomacromolecule nano prodrug and the nano preparation, and belongs to the technical field of nano preparations. According to the invention, the hydrogen persulfide is protected by utilizing ROS to respond to a small molecule group, so that the defect that the existing hydrogen persulfide is unstable is overcome; meanwhile, biomacromolecules are used as a carrier of the hydrogen persulfide, so that the liver targeting property, the water solubility and the biological safety of the hydrogen persulfide are improved, and multi-site modification and adjustability of the drug loading capacity are realized; in addition, the nano preparation is simple in reaction process, mild in condition and beneficial to clinical transformation.

The invention relates to glass powder as well as a preparation method and application thereof. The glass powder is prepared from raw materials including an inorganic mixture and glass clinker, by taking the total mass of the preparation raw materials of the glass powder as 100wt%, the percentage contents of the inorganic mixture and the oxides contained in the glass clinker are as follows: 40wt%-54wt% of SiO2, 5wt%-9wt% of Al2O3, 10wt%-30wt% of SrO, 5wt%-8wt% of B2O3, 5wt%-15wt% of ZrO2, 0wt%-5wt% of CaO, 1wt%-8wt% of MgO, 1wt%-2wt% of Y2O3 and 0wt%-5wt% of a sodium-potassium mixture. The glass powder provided by the invention does not contain barium element, and has good biological safety, X-ray developing capability and low-temperature chemical stability. According to the preparation method provided by the invention, impurities are prevented from entering the glass powder, and the glass powder is high in quality and good in batch stability.

The invention discloses a visual detection method of Seneca valley virus based on CRISPR-Cas13d (clustered regularly interspaced short palindromic repeats-associated protein 13d), and belongs to the technical field of molecular biology diagnosis. The method comprises the following steps: firstly, amplifying a target virus sequence by utilizing an isothermal amplification technology RAA, specifically identifying and amplifying signals by utilizing a CRISPR-Cas13d system, specifically identifying and amplifying signals by utilizing a crRNA sequence as shown in SEQ ID NO.13, and finally, visually observing a detection result by utilizing various visualization methods, according to the detection method provided by the invention, the SVA virus can be accurately and quickly detected in time on site, the detection capability of the SVA virus is remarkably improved, and the biological safety risk is reduced.

The invention discloses preparation and anti-tumor application of tumor cell membrane coated Ilisimus / copper-NLG919 bionic nanoparticles, and particularly relates to a bionic nano-drug which is characterized in that NLG919, ES and Cu < 2 + > are used as active ingredients to construct a self-assembled drug system (ECN), and meanwhile, a tumor cell membrane is used for coating the ECN to form ECNM; compared with a traditional EC, the built ECNM has the advantages that the systemic circulation stability, tumor targeting and tumor accumulation of the EC are remarkably improved, copper death and chemical kinetic therapy (CDT) can be efficiently triggered, a tumor immunosuppression microenvironment (TIM) can be synergistically reversed, and then a higher tumor immunotherapy effect is achieved. The nano-drug disclosed by the invention has good biological safety, cycling stability and homologous tumor targeting property, the preparation method is simple and convenient, and materials and equipment are easy to obtain.