Chemical crosslinking type glucan hydrogel and preparation method thereof

A technology of water and chemical cross-linking of glucan, which is applied in the field of biomedical functional polymer materials, can solve the problems such as toxicity of by-products of cross-linking reaction, and achieve the effect of short gel time and good biological safety.

Active Publication Date: 2015-12-02
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention proposes to use dextran natural polymers with good biological safety as the material basis, and prepare chemically cross-linked dextran hydrogels through chemical cross-linking with polyamino cross-linking agents after partial aldehydesylation. The cross-linking process The by-products are only water molecules, which solves the toxicity problem of the by-products of the cross-linking reaction

Method used

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  • Chemical crosslinking type glucan hydrogel and preparation method thereof
  • Chemical crosslinking type glucan hydrogel and preparation method thereof
  • Chemical crosslinking type glucan hydrogel and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0030] The chemically cross-linked dextran hydrogel has a structural formula as follows:

[0031] .

[0032] The preparation method of the above-mentioned chemically cross-linked dextran hydrogel, its specific operation steps are as follows:

[0033] (1) Preparation of aldylated dextran

[0034] Dissolve 5.0g dextran (molecular weight 40000g / mol) in water at room temperature according to the solid-liquid ratio of 12.5:100g / ml, and then place it in an ice-water bath according to the sugar unit / IO 4 - Add sodium periodate at a molar ratio of 1:1 to obtain a mixed solution. Stir the mixed solution at room temperature and avoid light for 4 hours. Use a regenerated cellulose dialysis bag (molecular weight cut-off: 7kD) to deionize the stirred solution. Dialyze in water for 2-3 days, change the deionized water every 3-5 hours during the dialysis process, freeze-dry after the completion of the dialysis to obtain a partially formylated dextran solid with a degree of formylation o...

Embodiment 2

[0039] The chemically cross-linked dextran hydrogel has a structural formula as follows:

[0040] .

[0041] The preparation method of the above-mentioned chemically cross-linked dextran hydrogel, its specific operation steps are as follows:

[0042] (1) Preparation of aldylated dextran

[0043] Dissolve 5.0g dextran (molecular weight 40000g / mol) in water at room temperature according to the solid-liquid ratio of 12.5:100g / ml, and then place it in an ice-water bath according to the sugar unit / IO 4 -Add sodium periodate at a molar ratio of 2:1 to obtain a mixed solution, stir the mixed solution for 4 hours at room temperature and in the dark, and use a regenerated cellulose dialysis bag (molecular weight cut-off: 7kD) to deionize the stirred solution Dialyze in water for 2 days, change the deionized water every 3~5h during the dialysis process, and freeze-dry after the dialysis to obtain a partly aldylated dextran solid with a degree of aldylation of 40% (40 sugar units pe...

Embodiment 3

[0047] The chemically cross-linked dextran hydrogel has a structural formula as follows:

[0048] .

[0049] The preparation method of the above-mentioned chemically cross-linked dextran hydrogel, its specific operation steps are as follows:

[0050] (1) Preparation of aldylated dextran

[0051] Dissolve 5.0g dextran (molecular weight 70000g / mol) in water at room temperature according to the solid-liquid ratio of 12.5:100g / ml, and then place it in an ice-water bath according to the sugar unit / IO 4 - Add sodium periodate at a molar ratio of 2:1 to obtain a mixed solution, stir the mixed solution at room temperature and under dark conditions for 6 hours, and use a regenerated cellulose dialysis bag (molecular weight cut-off: 8~14kD) for the stirred solution in the Dialyze in deionized water for 2 days, change the deionized water every 3~5h during the dialysis process, and freeze-dry after the dialysis to obtain a partially aldylated dextran solid with a degree of aldylation...

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Abstract

The invention relates to chemical crosslinking type glucan hydrogel and a preparation method thereof, and belongs to the technical field of biomedical functional polymer materials. The preparation method comprises the steps that glucan is dissolved in water at room temperature and then placed in an ice-water bath, and sodium periodate is added to obtain a mixed solution; the mixed solution is stirred for reaction for 2-6 h on the room temperature and dark conditions; the stirred solution is dialyzed with a regenerated cellulose dialysis bag in deionized water, and after dialysis is completed, freeze drying is performed to obtain partial hydroformylation glucan solids with the hydroformylation degree of 40-60 percent; the obtained partial hydroformylation glucan solids are dissolved in the deionized water to obtain an aqueous hydroformylation glucan solution, a multi-amino crosslinking agent is added in the aqueous hydroformylation glucan solution to be mixed evenly at the room temperature, and then the glucan hydrogel is prepared. The chemical crosslinking type glucan hydrogel is prepared by taking natural glucan macromolecules with the good biosafety as a material basis through chemical crosslinking of the partial hydroformylation glucan and the multi-amino crosslinking agent.

Description

technical field [0001] The invention relates to a chemically cross-linked dextran hydrogel and a preparation method thereof, belonging to the technical field of biomedical functional polymer materials. Background technique [0002] Hydrogel is a three-dimensional network structure formed by a polymer through physical or chemical crosslinking. It can swell in aqueous solution and retain a large amount of water without dissolving. Hydrophilic small molecules can diffuse in the hydrogel. In the 1960s, Wichterle and Lim synthesized cross-linked HEMA hydrogel for the first time (Nature, 1960.185:117-118). Its hydrophilic properties and potential biocompatibility aroused the great interest of biomaterial scientists. interest. This kind of hydrogel with a three-dimensional network structure has soft, rubber-like properties, its physical and chemical properties are similar to living tissue, and it has good biocompatibility, so it is used as a superabsorbent material, surgical soft ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/02C08J3/24C08J3/075C08B37/02
Inventor 苏红莹张稳吴易梅贾庆明陕绍云
Owner KUNMING UNIV OF SCI & TECH
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