Graphene oxide/polymer composite antibacterial material and preparation method thereof

A composite antibacterial and polymer technology, applied in the field of medical antibacterial materials, can solve the problems of film peeling and poor adhesion of the film base, and achieve the effects of easy operation, improved biocompatibility, and high biosafety.

Inactive Publication Date: 2016-12-07
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the graphene oxide-Ag multilayer film is prepared, the adhesion of the film base is very poor, and the film falls off

Method used

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  • Graphene oxide/polymer composite antibacterial material and preparation method thereof
  • Graphene oxide/polymer composite antibacterial material and preparation method thereof
  • Graphene oxide/polymer composite antibacterial material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]Cut the silicon rubber sheet into 2×2cm size, ultrasonically clean it in acetone, ethanol and deionized water for 5 minutes respectively, and dry it; place the silicon rubber after ultrasonic cleaning vertically in the UV box, close the door of the UV box, and turn on the UV box. lamp, carry out ultraviolet treatment for 20min, and the ultraviolet wavelength range is 180nm; activate the surface of the silicone rubber; then soak the treated medical silicone rubber in 2% ethanol solution of 3-aminopropyltriethoxysilane for 15 minutes After taking it out, rinse it with absolute ethanol and dry it in the air; immerse the silicone rubber after the grafted coupling agent in a graphene oxide suspension with a concentration of 50 μg / ml and soak for 15 minutes to obtain a graphene oxide / silicone rubber composite antibacterial material.

[0040] figure 1 It is the surface topography figure of the graphene oxide / silicone rubber composite antibacterial material obtained in this expe...

Embodiment 2

[0046] Cut the silicone rubber sheet into 2×2cm size, ultrasonically clean it in acetone, ethanol and deionized water for 5 minutes respectively, and dry it; place the silicon rubber after ultrasonic cleaning in an argon plasma atmosphere for 30 minutes to make the surface of the silicone rubber Activation; then soak the treated silicone rubber in 1% ethanol solution of 3-aminopropyltriethoxysilane for 5 minutes, take it out, rinse it with water and absolute ethanol and dry it in turn; the grafted coupling agent The final silicone rubber was immersed in a graphene oxide suspension with a concentration of 30 μg / ml for 20 min to obtain a graphene oxide / silicone rubber composite antibacterial material.

[0047] The antibacterial performance test of the composite antibacterial material obtained in the present invention: select Escherichia coli and Staphylococcus aureus as examples; the method is the same as in Example 1, and the finally obtained bacteriostatic rates are 92.6% and 8...

Embodiment 3

[0049] Cut the silicone rubber sheet into a size of 2×2 cm, ultrasonically clean it in acetone, ethanol and deionized water for 5 minutes, and dry it; place the silicon rubber after ultrasonic cleaning vertically in the UV box, close the door of the UV box, and turn on the UV box. lamp, carry out ultraviolet treatment for 20min, and the ultraviolet wavelength range is 200nm; activate the surface of the silicone rubber; then soak the treated medical silicone rubber in 19% ethanol solution of γ-mercaptopropyltrimethoxysilane for 10 min After taking it out, rinse it with water and absolute ethanol in turn and dry it; immerse the silicone rubber after the grafted coupling agent in a suspension of 10 µg / ml graphene oxide for 30 minutes to obtain a graphene oxide / silicone rubber composite antibacterial material .

[0050] The composite antibacterial material obtained in the present invention is tested for antibacterial performance: select Escherichia coli and Staphylococcus aureus a...

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Abstract

The invention discloses a graphene oxide/polymer composite antibacterial material and a preparation method thereof. The composite antibacterial material is characterized in that a polymer is subjected to surface modification and then is combined with graphene oxide dispersed in water, thus obtaining a graphene oxide antibacterial coating bonded on a polymer matrix, wherein the thickness of the antibacterial coating is 1 to 50nm. The preparation method of the graphene oxide/polymer composite antibacterial material comprises the following steps: firstly, performing ultrasonic cleaning on the polymer; secondly, performing surface modification on the polymer subjected to ultrasonic cleaning; thirdly, immersing an activated polymer matrix into a coupling agent solution and soaking; fourthly, taking out the soaked polymer, leaching with deionized water, then putting into a graphene oxide suspension liquid for 0.2 to 24 hours, taking out, leaching and naturally drying in air to obtain the graphene oxide/polymer composite antibacterial material. The invention designs and prepares the composite antibacterial material by taking graphene oxide as an antibacterial ingredient; the composite antibacterial material has a transparent antibacterial layer, is excellent in antibacterial property and is firmly bonded with the matrix.

Description

technical field [0001] The invention relates to a graphene oxide / polymer composite antibacterial material and a preparation method thereof, belonging to the field of medical antibacterial materials. Background technique [0002] Polymers are an important building block of biomedical materials. With its excellent performance, diverse structures and wide adaptability, it has become a trend to gradually replace traditional materials in various medical device industries. At present, there are 12 kinds of polymer materials widely used in medical devices in the world, and nearly 300 kinds of medical implants and artificial organs have been developed and applied using existing biomedical materials. Clinically, these materials need to be in contact with the human body surface, blood, and body fluids for a long time, and some even require permanent implantation in the body. But in the process of use, bacteria are easy to invade through various ways, and then cause infection. At th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/54A61L31/08A61L31/16
CPCA61L31/088A61L27/306A61L27/54A61L31/16A61L2300/10A61L2300/404A61L2400/12A61L2400/18A61L2420/02
Inventor 郭睿劼高扬贺建龙侯文娟张耀东
Owner TAIYUAN UNIV OF TECH
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