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Preparation for in-situ compounding simple-substance nano silvery bacteria cellulose membrane

A technology of bacterial cellulose film and bacterial cellulose is applied in the field of preparation of novel silver-containing antibacterial nano-bacterial cellulose film, which can solve the problem that restricts the development and application of antibacterial biomedical materials, and the bacterial cellulose film has no antibacterial activity and cannot prevent Wound infection and other problems, to achieve the effect of low cost, excellent antibacterial properties, and a wide range of uses

Active Publication Date: 2009-11-25
UNIV OF SCI & TECH BEIJING +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, bacterial cellulose membrane itself has no antibacterial activity and cannot prevent wound infection. Endowing bacterial cellulose membrane with strong antibacterial properties is very important for its application in the field of biomedical materials
[0004] At present, antibacterial bacterial cellulose membranes at home and abroad mainly use composite silver chloride particles and adding organic antibacterial agents. The process is complex, and problems such as poor antibacterial effect and poor ionization ability are difficult to overcome, which limits this type of antibacterial biomedical materials. development and application of

Method used

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  • Preparation for in-situ compounding simple-substance nano silvery bacteria cellulose membrane
  • Preparation for in-situ compounding simple-substance nano silvery bacteria cellulose membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The commercially available bacterial cellulose membrane prepared from Acetobacter xylinum was cut into 2×2 cm bacterial cellulose membrane samples.

[0044] Step 1. Take the bacterial cellulose membrane and rinse it with clean water several times to remove the medium and impurities on the membrane surface. Then immerse the membrane in a 0.1 mol / L NaOH solution and boil it at 100°C for 20 minutes to remove the bacteria and residual culture medium in the liquid membrane. At this time, the membrane is milky white and translucent. Then rinse with distilled water several times to control the pH value to about 7.2 to obtain a purified bacterial cellulose membrane. The bacterial cellulose membrane produced has a three-dimensional porous network structure (see attached figure 2 );

[0045] Step 2. Drop sodium hydroxide dilute solution into the silver salt solution with a concentration of 0.0001mol / L, which produces white silver hydroxide precipitate and then decomposes into brown s...

Embodiment 2

[0053] The commercially available bacterial cellulose membrane prepared by Sarcina spp. was cut into 2×2 cm bacterial cellulose membrane samples.

[0054] Step 1. Take the bacterial cellulose membrane and rinse it with clean water several times to remove the medium and impurities on the membrane surface. Then immerse the membrane in a 0.05mol / L NaOH solution and boil it at 100°C for 30 minutes to remove the bacteria and residual culture medium in the liquid membrane. At this time, the membrane is milky white and translucent. Then rinse with distilled water several times to control the pH to about 7.2 to obtain a purified bacterial cellulose membrane;

[0055] Step 2. Add a few drops of dilute sodium hydroxide solution to the silver salt solution with a concentration of 0.001 mol / L to produce a white silver hydroxide precipitate and then decompose into brown silver oxide and water; then add concentrated ammonia water dropwise to the solution, Until the brown precipitate just dissol...

Embodiment 3

[0063] The commercially available bacterial cellulose membrane made from soil rhizobia was cut into 2×2 cm bacterial cellulose membrane samples.

[0064] Step 1. Take the bacterial cellulose membrane and rinse it with clean water several times to remove the medium and impurities on the membrane surface. Then immerse the membrane in 0.2mol / L NaOH solution and boil it at 80°C for 15 minutes to remove the bacteria and residual medium in the liquid membrane. At this time, the membrane is milky white and translucent. Then rinse with distilled water several times to control the pH to about 7.2 to obtain a purified bacterial cellulose membrane;

[0065] Step 2: Add a few drops of dilute sodium hydroxide solution to the silver salt solution with a concentration of 0.01 mol / L to produce a white silver hydroxide precipitate and then decompose into brown silver oxide and water; then drop concentrated ammonia water into the solution, Until the brown precipitate just dissolved, the silver ammo...

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Abstract

The invention provides a preparation for the in-situ compounding simple-substance nano silvery bacteria cellulose membrane, and relates to the biological medical material field, characterized in that the bacteria cellulose membrane has special three-dimensional nano network structure, the silver-ammonia solution reacts with the chemical agent containing aldehyde group to generate silver simple-substance nano particle in situ in the network structure. In addition, in the invention, the special drying method is adopted to improve the defect of big fragility of the prepared silver-contained nano bacteria cellulose dry membrane. The bacteria cellulose membrane containing simple-substance nano silver particle provided by the invention has excellent antibacterial performance and simple preparation technique, and can be widely used in the biological medical field such as large-area wound dressing, bundling belt and the like, also can be used in the industry field such as the preparation of nano silver particle and silver catalyst, and the like.

Description

Technical field [0001] The invention relates to the field of biomedical materials, in particular to a method for preparing a novel silver-containing antibacterial nano bacterial cellulose film. Background technique [0002] Bacterial cellulose membrane (BC) is a natural biopolymer with basic chemical structure such as figure 1 Shown, it is a kind of unbranched macromolecular linear polymer connected by β-D-glucose through β-1,4-glycosidic bond, also known as β-1,4-glucose. Bacterial cellulose membrane has high crystallinity and high chemical purity. It does not contain hemicellulose, lignin and other cell wall components. It exists in the form of 100% cellulose, and the purification process is simple. The bacterial cellulose membrane has high water holding capacity and contains Many "pores" have good air and water permeability, and can absorb 60-700 times the dry weight of moisture. Bacterial cellulose membrane has ultra-fine nanofiber network, high tensile strength and elastic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M11/83C12P19/04A61L15/28A61L15/18A61L15/46C12R1/02C12R1/38C12R1/41C12R1/025C12R1/05C12R1/065C12R1/01
Inventor 郑裕东吴健杨槐王瑞欣奚廷斐刘国权
Owner UNIV OF SCI & TECH BEIJING
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