The invention provides an activated anti-swelling shrinkage agent and application thereof. The structural formula of the activated anti-swelling shrinkage agent is as follows: R1R2R3N<+>Y1N<+>R4R5R6.X<2->, R1R2R3N<+>Y2N<+>(R7)(R8)Y3N<+>R4R5R6X<3->, wherein R1 to R8 refer to hydrogen, alkane radical, aromatic alkane radical, polyoxyethylene radical, polyoxypropylene radical, polyoxyethylene/propylene segmented copolymer, poly-glycosidic bond and various substituent groups thereof respectively and independently; X<-> is Cl<->, Br<->, I<->, RCO3<->, COO<->, RSO3<->, RSO4<->, and RPO4<-> atoms, and R is H, alkyl or substituent alkyl independently; Y1 to Y3 are -(CH2)n- (n=1-10), -(CH2)n-CH=CH-(CH2)m- (n+m=8), -(Ph)n- (n=1-4), -(CH2)mO(CH2)n- (m+n<10), -(CH2)n-O-(EO)m- (m+n<10), -(CH2)n-O-(PO)m- (m+n<10) and various substituent groups. The activated anti-swelling shrinkage agent is used for protection of sensitive reservoir with high clay content, can be used independently, and can also be used as an additive to be used in oil-water well work.