74 results about "Sulfation" patented technology

The invention discloses a functional lipid compound for nano-liposome wrapping and a preparation method, and relates to the technical field of functional lipid compounds, the functional lipid compound comprises (a) a polyphenol-lipid covalent conjugate which is composed of a polyphenol active unit selected from curcumin, dihydroquercetin or derivatives thereof, and (b) a lipid covalent conjugate which is composed of a polyphenols active unit selected from curcumin, dihydroquercetin or derivatives thereof and a polyphenols active unit selected from curcumin, dihydroquercetin or derivatives thereof; the conjugate is covalently linked to a phosphatidyl ethanolamine or cholesterol skeleton through a cleavable linking group, and the conjugate can be integrated into a nano-liposome membrane and has the functions of structural support and biological activity; (b) a microenvironment-responsive functional phospholipid, which is a phospholipid derivative having a functional group responsive to an inflammatory microenvironment specific stimulus modified on a hydrophilic head group or a hydrophobic chain of a phospholipid molecule, the specific stimulus being selected from local pH < = 6.5, reactive oxygen species (ROS) concentration > = 10 [mu] M or matrix metalloproteinase MMP-2 / 9 overexpression; and (c) a bionic exosome membrane lipid component, wherein the bionic exosome membrane lipid component comprises sphingosine-based glycolipid or sulfated cholesterol separated from the plant-derived exosome.

This invention provides an antiviral sulfated mulberry leaf oligosaccharide, its preparation method, animal feed, and applications, belonging to the field of oligosaccharide technology. The invention involves microwave degradation and H2O2-Vc degradation of mulberry leaf polysaccharides, followed by sulfation modification of the degradation products to obtain sulfated mulberry leaf oligosaccharides. Experiments have shown that adding sulfated mulberry leaf oligosaccharides to feed for aquaculture can promote the growth of largemouth bass, improve feed utilization, antioxidant capacity, lipid metabolism, immune function, and enhance resistance to viral infections.

The application relates to the technical field of surfactants, in particular to a pentadecyl phenol alkoxyl ether sodium sulfate surfactant and a preparation method thereof. The preparation method of the pentadecyl phenol alkoxyl ether sodium sulfate surfactant comprises the following steps: after pretreatment, cashew nut shell liquid is selectively hydrogenated to obtain pentadecyl phenol with a specific composition; then, alkoxylization reaction is carried out under the condition of an alkaline catalyst to obtain pentadecyl phenol polyalkoxyl ether; and the pentadecyl phenol polyalkoxyl ether is sulfated and neutralized to obtain the pentadecyl phenol alkoxyl ether sodium sulfate surfactant. The surfactant improves the problem that the activity of the surfactant is reduced when the saturation of the pentadecyl phenol is too high or too low; ensures that the final product has good fluidity at low temperature, guarantees the continuity of production, effectively reduces the occurrence of over-sulfation; and simultaneously improves the production efficiency and reduces the cost.

The invention relates to a microbial growth activation accelerant based on rare earth elements as well as a preparation method and application thereof, and belongs to the field of resources and environments. The microbial growth activation accelerant based on the rare earth elements is prepared from the following components: 1 to 150g of a rare earth compound, 0.2 to 2g of pantothenic acid, 0.2 to 2g of nicotinic acid, 0.02 to 0.1 g of nicotinamide and 1000g of deionized water, the rare earth compound is one or combination of more of chlorides of lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, scandium and yttrium, nitric acid compounds and sulfuric acid compounds. A large number of cheap light rare earth elements are used as raw materials of the microbial accelerator, a new utilization approach is provided for the light rare earth elements, the light rare earth elements are converted into high-added-value products, pollution of the light rare earth elements to the environment is reduced, and meanwhile new elements are introduced into the field of microbial accelerators. More importantly, the preparation method of the microbial growth activation accelerant based on the rare earth elements provided by the invention is simple in production process and convenient for large-scale production.

The application belongs to the technical field of chondroitin sulfate preparation, and particularly relates to application and application method of liquid sulfur dioxide in preparation of chondroitin sulfate or chondroitin sulfate salt. In the application, liquid sulfur dioxide is used as a solvent to perform sulfonation modification treatment on unsulfated chondroitin, on the one hand, the use of traditional high-boiling organic reagents is avoided, the difficulty of three-waste treatment is reduced, and the process is more green and environmentally friendly; on the other hand, the post-treatment operation of the sulfonation reaction is simpler, and sulfur dioxide can be removed from the system by only temperature control or pressure adjustment, so that solvent residues possibly existing in the final product are avoided, and the product is safer. In addition, by adjusting the key conditions of the sulfonation reaction, the proportion of chondroitin sulfate with 6 independent sulfation in the disaccharide unit of the sulfonation product is 70% to 90%, the reaction is stable and reliable, and the sulfonation rate is high.

The invention relates to the technical field of sodium chondroitin sulfate, in particular to sodium chondroitin sulfate with a high cartilage repair effect and a preparation method thereof.The sodium chondroitin sulfate initial feed liquid is provided, the pH value of the sodium chondroitin sulfate initial feed liquid is adjusted to a preset acidic pH value, and at the preset reaction temperature, the pH value and the reaction temperature are maintained for reaction time, so that the chondroitin sulfate with the high cartilage repair effect is obtained. The method comprises the following steps: adding a sulfated disaccharide unit CS-0 into a feed liquid to precipitate out a non-sulfated disaccharide unit CS-0 in the feed liquid, carrying out solid-liquid separation on the feed liquid, and removing the CS-0 precipitate to obtain a supernatant; pumping the supernatant into a gradient membrane separation system under controlled transmembrane pressure difference and feed liquid temperature, and separating the supernatant into three component flows with different molecular weight intervals; the concentration of the three component flows is monitored, the volume flow of each component flow is dynamically adjusted according to the preset molecular weight and mass distribution proportion, the chondroitin sulfate sodium product with the fixed molecular weight distribution is obtained, and the biological activity and the application value of the chondroitin sulfate sodium are improved.

This invention discloses a method for preparing dodecanoic acid lactam, comprising an oximation reaction of cyclododecanone, a rearrangement reaction of cyclododecanone oxime, and extraction and purification. The oximation reaction of this invention uses a cobalt-based MOF catalyst, which has high catalytic activity and can significantly improve the conversion rate of the cyclododecanone oximation reaction, thereby improving the overall reaction efficiency, reducing the formation of by-products, and thus improving the purity of the target product. In the rearrangement reaction of cyclododecanone oxime, zirconium oxide sulfate is used as a catalyst. This catalyst has good catalytic performance under high temperature conditions and can effectively promote the rearrangement reaction. Simultaneously, the ionic liquid is used as a solvent, which not only has good solubility but is also environmentally friendly and easy to recycle, reducing production costs and environmental impact.

This invention belongs to the field of surfactant preparation technology, specifically relating to a method for preparing a sulfate ester salt type surfactant. The method includes the following steps: olefins and concentrated sulfuric acid are separately introduced into a microchannel reactor equipped with a catalyst section and mixed and reacted under ultrasonic conditions to obtain an intermediate product; an aqueous solution of NaOH or KOH is added to the intermediate product, the temperature is raised to 90-105℃, and the mixture is stirred and refluxed for 1-2 hours to obtain the sulfate ester salt type surfactant. This invention combines a microchannel reactor with fine chemical synthesis and successfully synthesizes secondary alkyl sulfates. By accelerating the reaction with a catalyst and ultrasound, increasing the phase contact area, and controlling the reaction temperature at a low level, the degree of olefin sulfation is greatly improved, thereby increasing the yield of secondary alkyl sulfates. The method is safe, environmentally friendly, easy to operate, simple in process, and easy to control. It is expected that production can be scaled up to industrial scale through array arrangement.

Biomaterials disclosed herein can comprise a hydrogel comprising PEG, gelatin, and a glycosaminoglycan with sulfated moiety; and chondrogenic, osteogenic, and immunomodulatory cytokines; wherein the biomaterial is capable of potentiating bone regeneration in a compromised wound while reducing inflammatory response. The glycosaminoglycan with sulfated moiety can comprise heparin, heparan sulfate, keratin sulfate, chondroitin sulfate, dermatan sulfate, and / or similar materials. The biomaterial can further comprise mesenchymal stem cells (MSCs), a crosslinking initiator, microparticles and nanoparticles, and / or other materials. The biomaterial can be injectable into a wound, or the biomaterial can be loaded in, or further comprise a porous scaffold providing mechanical support for other components of the biomaterial, such that it can be implanted into a wound.

A water treatment system includes a water stream configured to provide raw water to be treated, a coagulant source configured to hold one or more sulfated coagulants, and one or more photoreactors configured to activate the one or more sulfated coagulants to produce an activated sulfated coagulant and configured to add the activated sulfated coagulant to the water stream within a determined period. Methods of water treatment are also disclosed.

This invention discloses a fucose polymer, its preparation method, and its applications. Using natural fucoidan sulfate ester as a template, a fucose polymer with well-defined and homogeneous structures is prepared via an olefinic metathesis ring-opening polymerization reaction. The structure involves different glycosidic bond linkages, degrees of polymerization, sugar chain lengths, and sulfate sites. The amphiphilic fucose polymer self-assembles into spherical nanoparticles, exhibiting inhibitory activity against type I herpes simplex virus infection. The sulfated fucoidan polymer with a degree of polymerization of 20 shows the best antiviral effect. This invention achieves efficient and controllable synthesis of fucoidan oligosaccharide polymers and has the potential value as a novel anti-herpes simplex virus drug, which can be applied in the preparation of anti-herpes simplex virus drugs.

This invention discloses a flotation separation method for removing talc from molybdenite using sodium alginate sulfate. The method involves preparing a raw slurry from talc-type molybdenite, controlling the pH of the slurry to be 6.0–10.0. Sodium alginate sulfate is added to the slurry and stirred. Then, an anisopolar collector is added and stirred to condition the slurry. A frother is then added to obtain a mixed slurry. Finally, the mixed slurry is subjected to aerated flotation. The collected frothy product is the molybdenum concentrate, and the product in the tank is the talc-containing tailings. This invention, by adding sodium alginate sulfate (SAS), which has high electronegativity and strong chelating ability, as a specific inhibitor to the flotation system, blocks the contact between the collector and talc. Simultaneously, its strong electrostatic repulsion effectively prevents non-specific adsorption on the negatively charged molybdenite surface. This invention significantly improves the grade and recovery rate of molybdenum concentrate and has extremely high industrial promotion and engineering application value.

The invention belongs to the technical field of plant polysaccharide, and discloses modified acanthopanax polysaccharide as well as a preparation method and application thereof. Acanthopanax senticosus is taken as a raw material, acanthopanax senticosus polysaccharide ASPS is extracted through a microwave-enzyme synergistic extraction method, ASPS-I, ASPS-II and ASPS-III are obtained through separation and purification of a DEAE-650M cellulose chromatographic column, and selenized acanthopanax senticosus polysaccharide or sulfated acanthopanax senticosus polysaccharide is obtained through chemical modification. The chemical modification process is simple and convenient, high in safety and few in by-products, organic solvents are not used in the whole process, and the green chemistry principle is met. The eleutherococcus senticosus selenized polysaccharides SeASPS-I, SeASPS-II and SeASPS-III disclosed by the invention, or the eleutherococcus senticosus sulfated polysaccharides sASPS-I, sASPS-II and sASPS-III disclosed by the invention can be used for effectively improving the motion state of BR5270 nematodes.

The invention relates to a polycarboxylic acid dispersing agent and a preparation method thereof, and the polycarboxylic acid dispersing agent is prepared from the following raw materials in parts by weight: 28-32 parts of sodium methylallyl sulfonate; 170 to 190 parts of polyether monomer; 8-12 parts of a modified amide monomer; 16 to 18 parts of unsaturated acid monomer; 1.8 to 2.2 parts of an oxidizing agent; 1.8 to 2.2 parts of a reducing agent; 2.2 to 2.8 parts of a chain transfer agent; and water; the polyether monomer is prepared from the following raw materials: phosphate ester, ethylene oxide and epoxypropane; the modified amide monomer is obtained by modifying N-hydroxymethyl acrylamide with a sulfating agent. According to the invention, the modified amide monomer containing a strong polar sulfate group and the polyether monomer with a specific EO / PO chain segment ratio are copolymerized, so that the synergistic effect of'reinforced anchoring 'and'steric hindrance' is realized, the defects of unfirm anchoring and insufficient steric hindrance of a traditional dispersant are overcome, the adsorption stability of the dispersant on the surface of a pigment is obviously enhanced, and the dispersion is more stable. Therefore, the viscosity of the coating is obviously reduced, and the fluidity of the coating is improved.

The invention relates to the technical field of environmental governance and functional materials, in particular to a codonopsis pilosula polysaccharide derivative as well as a preparation method and application thereof. The codonopsis pilosula polysaccharide derivative is mainly prepared from codonopsis pilosula polysaccharide through carboxymethylation or sulfation modification reaction. The codonopsis pilosula polysaccharide derivative is prepared on the basis of natural codonopsis pilosula polysaccharide through simple process steps, and the codonopsis pilosula polysaccharide derivative is especially used for adsorbing and enriching divalent lead ions as a biological adsorbent, so that the problems of high toxicity, high cost, complex adsorption material synthesis process and the like in a lead treatment method in the prior art are solved.

Surface‑bound procatalysts for hydrogenolysis of a polyolefin feed include an acidic sulfated support and cationic transition metal complexes M+Ly surface‑bound to at least one surface sulfate site QS − of the acidic sulfated support. The transition metal M is selected from the group consisting of Fe, Ni, Co, Cu, and Zn. The y number of ligands is 1, 2, or 3. Each ligand is a monodentate or multi‑dentate ligand coordinated to the transition metal with a hapticity greater than 1. Methods for hydrogenolysis of a polyolefin feed include contacting the surface‑bound procatalyst with a hydrogen feed to form active catalyst sites comprising hydride complexes M+H each surface‑bound to at least one anionic site of the sulfated support; contacting the active catalyst sites with the polyolefin feed in the presence of hydrogen; and allowing the polyolefin feed to react in the reactor to obtain a hydrogenolyzed product.

The invention discloses a microsphere core-shell structure catalyst and a preparation method and application thereof in carbonyl sulfide hydrolyzing.The preparation method of the microsphere core-shell structure catalyst comprises the following steps that cobalt salt, nickel salt, urea and a first solvent are evenly mixed to form a clear solution, the clear solution is subjected to a hydrothermal reaction at the temperature of 100-150 DEG C, a wet solid product is obtained, and the microsphere core-shell structure catalyst is obtained. And drying the wet solid product to obtain an inner core, uniformly mixing the inner core, cetyltrimethylammonium bromide and a second solvent, adding ammonia water under a stirring condition until the pH is 12-13, dropwise adding tetraethyl orthosilicate, reacting at room temperature under a stirring condition for 12-20 hours after dropwise adding is completed, centrifuging after the reaction is completed to obtain a precipitate, washing the precipitate to be neutral, and drying, so as to obtain the catalyst. The microsphere core-shell structure catalyst is obtained. The microsphere core-shell structure catalyst can effectively prevent sulfur and sulfation on the surface of the catalyst, so that the stability of the catalyst is remarkably improved while the catalytic activity is guaranteed.

The application provides oligosaccharide, a preparation method thereof and application thereof in aquatic feed, and belongs to the technical field of plant polysaccharide. The mulberry polysaccharide is sequentially subjected to pectinase enzymolysis, H2O2-Vc degradation and microwave degradation, the degradation product obtained is subjected to sulfation modification, and sulfated mulberry oligosaccharide is obtained. The sulfated mulberry oligosaccharide has the effects of improving the antioxidant capacity of aquatic animals, improving the antiviral property of aquatic animals, improving the immune capacity of aquatic animals and improving the growth performance of aquatic animals, and can be used as a feed additive in aquatic breeding.

This invention provides a modified fucoidan composite hydrogel, its preparation method, and its application, belonging to the field of hydrogel technology. The preparation method of the composite hydrogel includes the following steps: dissolving fucoidan in an organic solvent, then adding a sulfonating agent to carry out a sulfation reaction; after the reaction, allowing it to stand, precipitate, wash, dry, and grind sequentially to obtain persulfated modified fucoidan; preparing a persulfated modified fucoidan solution, then mixing it evenly with a carboxymethyl chitosan solution, a laver polysaccharide solution, and a hyaluronic acid solution; then adding a polyethylene glycol solution, a 1,4-phenylenediboric acid solution, salmon protein active peptides, and docosahexaenoic acid; finally, adding a crosslinking agent to obtain a mixed solution, and stirring to obtain a composite polysaccharide hydrogel. This composite hydrogel has good mechanical properties and biocompatibility, and can accelerate the healing of chronic wounds in type 2 diabetes.

Provided is an adjuvant for mucosal vaccines comprising a sulfated archaeosome comprising a sulfated glycoarchaeol. The glycoarchaeol may be present as a pharmaceutically acceptable salt. The adjuvant

The invention relates to the technical field of D-chiro-inositol production, in particular to a process method for preparing D-chiro-inositol by taking kasugamycin hydrochloride as a raw material, which comprises the following steps: taking kasugamycin hydrochloride as a raw material, adding a sulfated zirconium-titanium composite oxide catalyst with SO4 < 2-> loading capacity of 3M, and controlling the reaction temperature and time to prepare D-chiro-inositol. The obtained hydrolysate is filtered, the collected filtrate enters an anion resin column, the obtained effluent is subjected to nanofiltration membrane concentration and vacuum concentration treatment, ethyl alcohol is added into the collected concentrated solution, heat preservation treatment is performed for a period of time, then cooling crystallization is performed, water is added into a D-chiro-inositol crude product collected through suction filtration, stirring and dissolving are performed, then decoloration treatment is performed, and the D-chiro-inositol is obtained. Adding ethanol into the collected decoloring solution, cooling and crystallizing after crystals are separated out, and drying the collected crystals after suction filtration to obtain a D-chiro-inositol product; the process method is simple in process and simple to operate, can obtain the D-chiro-inositol product with high yield and high purity, and is suitable for industrial production.

The application discloses a kind of Ascophyllum nodosum fucoidan ANFS and its preparation method and application in preparation for preventing and treating alzheimer's disease preparation, belong to marine biological medicine technical field.The main chain of the Ascophyllum nodosum fucoidan ANFS is composed of (1→3) connected α-L fucose residue, and branch is monosaccharide or sulfate group.Sulfated modification occurs at C-2 and C-4 of fucose residue, and its molecular weight is 15-30 kDa.The application proves by experiment, ANFS can significantly improve the motion behavior defect of zebra fish, inhibit acetylcholinesterase activity, improve catalase and glutathione peroxidase activity, reduce intracellular reactive oxygen species level, reduce brain neuron apoptosis, and effectively protect the integrity of blood-brain barrier.The polysaccharide is rich in source, and preparation process is simple, and safety is high, has wide application prospect in the development of marine medicine and functional product for treating alzheimer's disease.

This invention discloses a sulfated modified sodium alginate, its preparation method, and its applications. Urea is heated and melted to obtain urea liquid. Sodium alginate powder is added to the urea liquid to form a dispersion. The mixture is then cooled to 50-70°C, aminosulfonic acid is added, and a protective atmosphere is introduced at a flow rate of 50-200 mL / min. The temperature is then raised to 100-140°C, and the reaction yields sulfated modified sodium alginate. When this product is used as a flotation depressant for magnesium silicate gangues, it utilizes the specific bidentate chelating effect and strong hydration ability of the sulfate ester groups on the talc surface to form a dense molecular shielding film. Simultaneously, it effectively avoids non-specific adsorption on the surface of valuable metal minerals (such as molybdenite) through strong electrostatic repulsion. This invention not only significantly improves the flotation separation efficiency of valuable minerals but also features a simple, environmentally friendly synthesis process with broad industrial application prospects.

The invention provides a two-dimensional flaky transition metal phosphate nano material based on a self-assembly template method and a preparation method and application thereof, the preparation method comprises the following steps: dissolving P123 and lauryl sodium sulfate in a binary solvent to prepare a composite micelle soft template solution, then adding a complexing agent and a transition metal source, carrying out complexation reaction, then adding phosphoric acid, and carrying out self-assembly to obtain the two-dimensional flaky transition metal phosphate nano material based on the self-assembly template method. Enabling the transition metal phosphate precipitate to be self-polymerized on the composite micelle template, so as to prepare a two-dimensional flaky transition metal phosphate nano material; on the other hand, the two-dimensional flaky transition metal phosphate nano material is roasted, or vulcanized and roasted to prepare solid acid; furthermore, the two-dimensional flaky transition metal phosphate nano-material or solid acid prepared from the two-dimensional flaky transition metal phosphate nano-material is used for catalyzing hydrolysis-condensation reaction of trimethylchlorosilane-terminated methylhydrodichlorosilane to prepare high-hydrogen-content silicone oil, and compared with other sulfated metal oxides, the two-dimensional flaky transition metal phosphate nano-material has an amorphous structure and higher catalytic activity.

Embodiments of the present invention provides recombinant systems, methods, and compositions for the biological production of Testosteronan (Testan), a linear α-(1→4)-linked glucuronic acid–N-acetylglucosamine polysaccharide. Microbial hosts engineered to express full-length CtTS, N-terminal truncation variants (including d64-CtTS), or the Pseudomonas CIPTS homolog synthesize high–molecular-weight Testan (≥800 kDa) with low polydispersity. Structural analysis by ¹H NMR and 2D HSQC demonstrates that all recombinant enzymes produce Testan that is chemically indistinguishable from native polymer. Purification using ultrafiltration and strong-anion exchange chromatography yields highly defined molecular-weight fractions, including monodisperse populations (PDI ~1.02). The invention further provides sulfated derivatives of Testan produced via aqueous sulfation methods, as well as Testan and functionalized Testan compositions useful for chromatographic stationary phases, biomaterial scaffolds, and chemically modifiable polymer platforms. These systems provide the first scalable, fermentation-based production methods for Testan and Testan-derived materials.

The application discloses a Cordyceps sinensis polysaccharide extraction method, through step-by-step pH adjustment and gradient ethanol precipitation, CS-F30 polysaccharide and OSWP-2 polysaccharide can be extracted in one Cordyceps sinensis raw material, not only the extraction efficiency is improved, but also the extraction amount and purity are increased, the defects of the reduction of the extraction amount and the extraction efficiency in the CS-F30 polysaccharide and the OSWP-2 polysaccharide extraction process in the prior art are solved; the sulfated groups of CS-F30 are ionized by adjusting the pH, the solubility is increased, and the CS-F30 is reserved in the supernatant, the OSWP-2 polysaccharide is precipitated due to the close neutral isoelectric point and is removed by centrifugation, and is reserved in the precipitate, the method for separating based on the differences of the polysaccharide molecular structure and the charge characteristics can accurately separate the two polysaccharides, the mutual doping of the polysaccharides in the traditional extraction method is avoided, and the extraction accuracy and efficiency are improved.

The invention provides a sulfuryl quaterphenyl [3] arene sulfate macrocyclic compound as shown in a formula IV as well as a preparation method and an application of the sulfuryl quaterphenyl [3] arene sulfate macrocyclic compound. The preparation method of the compound comprises four steps of reaction: Suzuki coupling, cyclization, demethylation and sulfation, the process is simple, the total yield is high, and the yield of each step of reaction is superior to 70%. The compound has excellent water solubility and biocompatibility and can form a stable host-guest inclusion complex with an anti-cancer drug terpyridyl ruthenium through hydrogen bonds, pi-pi accumulation and other supramolecular acting forces, and the binding constant of the compound is as high as (3.59 + / -1.48) * 10 < 6 > M <-1 >. A cytotoxicity experiment shows that the half inhibitory concentration (IC50) of the inclusion complex to human colon cancer cells HCT116 is 2.95 mu M, and compared with a free terpyridyl ruthenium drug (IC50 = 64.93 mu M), the anticancer activity of the inclusion complex is improved by about 22 times. The invention provides an efficient and convenient new strategy for drug delivery, the bioavailability and the treatment effect of the drug can be remarkably improved without covalent modification of drug molecules, and the drug delivery system has a good industrialization prospect.

The present invention is in the field of medicine and provides compositions for the treatment and / or prevention of protein aggregation diseases.

The present disclosure relates to uses and methods implementing a cell free extract (CFE) having an activity for converting adenosine 2',3'-cyclic phosphate 5'-phosphosulfate (cyclo-PAPS) into 3'-phosphoadenosine-5'-phosphosulfate (PAPS) useful for sulfating a substrate.

The present application belongs to the technical field of natural product chemical modification, and particularly relates to a chemically modified rare ginsenoside derivative, a preparation method and application thereof. The present application takes rare ginsenoside as raw material, introduces a sulfate group by sulfating modification on the rare ginsenoside to obtain a chemically modified rare ginsenoside derivative; the modifier used in the sulfating modification is a sulfonating agent. The rare ginsenoside is synthesized by conversion with ginsenoside Rb1 as raw material and AlCl3 as catalyst in an ethanol system. The modification method of the present application is simple in operation steps, does not require special equipment, is suitable for large-scale production, and has a broad application prospect in the field of drug preparation development and the like.