196 results about "Antimicrobial" patented technology

The present disclosure relates generally to antimicrobial gels. In particular, the present disclosure relates to an antimicrobial gel comprising a eutectic solvent and a gelling agent which can be used as a drug delivery vehicle for antimicrobial agents, including for the topical delivery of antimicrobial agents to the skin of a subject. The present disclosure also relates to processes for preparing the antimicrobial gel, and to methods, uses and compositions comprising the antimicrobial gel.

An image forming apparatus includes: a forming unit configured to form an image on a sheet by forming a plurality of toner images using a plurality of types of toner, and transfer the plurality of toner images onto the sheet, or transfer the plurality of toner images onto the sheet via an intermediate transfer member; and a controller configured to control the forming unit to form a formed image and an antimicrobial pattern on the sheet based on first image data representing the formed image, wherein at least one first toner out of the plurality of types of toner is antimicrobial toner that includes an antimicrobial agent, at least one second toner out of the plurality of types of toner is non-antimicrobial toner that does not contain the antimicrobial agent, and the antimicrobial pattern is formed using the first toner.

Novel compositions are described, each comprising at least one active constituent that has a 12-carbon atom backbone as a 12-carbon chain base structure having at least a sub-terminal nitrogen and no terminal amino group. One of the active constituents is Boc-12-Ado-OH (BOA) and / or N,N-dimethyldodecylamine N-oxide (LO). Novel particle or liposomal compositions comprising at least BOA and / or LO may be prepared with an emulsifier and / or lipid and optionally a biopolymer, and may be formulated into pharmaceutically acceptable formulations and / or medicaments with or without one or more pharmaceutically acceptable carriers or excipients for utilization as an antimicrobial against one or more microbial pathogens. The novel antimicrobial compositions have broad-spectrum growth inhibitory or other destructive activity against microbial pathogens, biofilms produced by one or more pathogens, and biofilm infections.

Feed additives including Chlamydomonas reinhardtii and a medium-chain fatty acid provide reduced risk of bacterial infection in animals. The feed additives are administered to animals in feed compositions.

The invention belongs to the technical field of polyurethane elastomers, and particularly relates to a modified polyester polyol, an antibacterial polyurethane microporous elastomer and a preparation method of the elastomer. The modified polyester polyol is prepared by adopting graft modification Ag (at) SiO2, and the antibacterial polyurethane microporous elastomer is prepared from the modified polyester polyol. The antibacterial polyurethane microporous elastomer is mainly prepared by mixing and curing a component A and a component B, the component A mainly comprises conventional polyester polyol and modified polyester polyol, and the component B mainly comprises conventional polyester polyol, polyether polyol and isocyanate; according to the antibacterial polyurethane microporous elastomer and the preparation method thereof provided by the invention, the prepared polyurethane microporous elastomer is long-acting and stable in antibacterial performance and uniform in dispersion, and keeps excellent physical and mechanical properties and a microporous structure at the same time.

The present invention relates to an antimicrobial oligomer and to an antimicrobial coating composition comprising said antimicrobial oligomer. The present invention also relates to a medical device comprising the antimicrobial coating composition and to a method for coating said coating composition on a medical device.

A composition is provided that includes hydrolyzed collagen, at least one biguanide, at least one vicinal diol, and at least one chelating agent. The composition exhibits at least 2-log reduction of planktonic microbes within 24 hours. Methods of using the composition are also provided.

The present invention pertains to use of sodium diacetate (NaHAC2) as an antimicrobial agent against bacteria growing in biofilms. The aspects of the invention include a wound care product comprising sodium diacetate, a kit comprising a wound care product, and a method of treating an infected wound.

A dynamic antimicrobial hydrogel based on natural receptor-ligand recognition, and a preparation method and use thereof are provided. A ligand vancomycin and a receptor AA-based material each are first modified with a modification material, and then a photoinitiator is added to prepare a hydrogel material under irradiation of ultraviolet (UV) light. In the hydrogel, a three-dimensional (3D) network structure is formed through crosslinking. After undergoing a fracture under an external pressure, the hydrogel can rapidly heal itself through crosslinking due to a ligand-receptor interaction and a multi-hydrogen-bond interaction, which bio-mimicks a natural ligand-receptor interaction to realize the dynamics of the hydrogel material. The high antiomicrobial activity of vancomycin imparts the functionality of the hydrogel material; and the physiologically-derived monomer improves the biocompatibility and reduces the biological toxicity.

The microorganism strain Pediococcus acidilactici TAK 589 CoccobEst is a new antimicrobial and antioxidant probiotic, CoccobEst inhibits the growth of the enteropathogens L. monocytogenes, E. coli, S. enteritidis, S. typhimurium, S. sonnei, S. aureus, E. faecalis and C. sakazakii, but does not inhibit lactobacilli of natural intestinal microbiota. The strain's antimicrobial properties are enhanced by periplasmic peptidoglycan hydrolases with proteolytic activity. CoccobEst is used as a zootechnieai feed additive to prevent bacterial infections in the gastrointestinal tract of farm animals and pets and to prevent and reduce diarrhea. CoccobEst has highly active antioxidant defense system, increasing the redox activity of glutathione and reducing oxidative stress in cells. Therefore, CoccobEst is used as a food supplement or functional food for humans to prevent bacterial infections of the gastrointestinal tract and to prevent and reduce oxidative stress. In addition, CoccobEst is used as a starter culture in fermentation of vegetables.

Provided in the present invention are an antimicrobial whitening composition, a white synthetic leather substrate and a preparation method therefor, and an antimicrobial synthetic leather. The antimicrobial whitening composition comprises a cationic antimicrobial agent, an antimicrobial organic substance and a solvent, wherein the cationic antimicrobial agent comprises at least one of a polymeric quaternary ammonium compound, polyethyleneimine, chitosan, a biguanide compound and a polymeric biguanide; and the antimicrobial organic substance comprises at least one of a terpene compound and a derivative thereof, a phenolic compound, an essential oil, an antifungal agent, a preservative and a disinfectant. The man-made leather prepared by means of the antimicrobial whitening composition of the present invention has good performance in terms of both long-lasting antimicrobial properties and maintaining a high whiteness.

The present disclosure provides a delivery system 1 comprising a fibrous substrate 10 with continuous pores 13 and a composition homogenously bonded to the pores 13. The fibrous substrate 10 comprises at least a predetermined percentage of cotton and one or more materials selected from the group of consisting spandex, nylon, silver and antimicrobial mesh. The composition comprises a predetermined percentage of beeswax and a predetermined percentage of mineral oil. The predetermined percentage of beeswax is greater than the predetermined percentage of mineral oil.

The invention relates to a pyruvate kinase-targeted compound shown as a formula I, a preparation method and application thereof, and application of the pyruvate kinase-targeted compound serving as a plant antibacterial agent, and part of the pyruvate kinase-targeted compound shows excellent bactericidal activity.

A general formula for lysins based on which the activity and functionality are further screened and 24 lysins are identified and further investigated, nine of which are characterized. These lysins exhibit potent bactericidal activity, capable of lysing multiple species of Staphylococcus, Streptococcus, and / or Enterococcus; demonstrate robust environmental resistance and stability, retaining activity under varying temperatures, NaCl concentrations, pH levels, and in immune serum; and effectively treat localized and systemic infections. These lysins and their variants are promising as antimicrobial agents for eradicating bacteria, preventing bacterial infections, or treating bacterial infections (caused by genera Staphylococcus, Streptococcus, and / or Enterococcus).

The invention relates to a medical treatment unit, in particular a dental treatment unit, comprising a water leading system and a measurement unit for the quantitative measurement of an antimicrobial agent content in water contained in the water leading system.

Peptides for use in systems that prevent the interaction of the FadA protein released from the Fusobacterium nucleatum (F. nucleatum) bacterium with E-cadherin, which has a carcinogenic effect, or the inhibition of the microorganism with antimicrobial agents and that will inhibit the carcinogenesis mechanisms of F. nucleatum infection and enable the development of therapeutic systems against infections that may occur due to the decreased immunity of patients undergoing cancer treatment with the use of peptides with anti-cancer and antimicrobial properties by developing ten peptides with FadA protein binding energy greater than −11.6 kcal / mol. Peptides with anticancer and antimicrobial properties allow the development of therapeutic systems to prevent F. nucleatum infection, to prevent cancer development after F. nucleatum infection, or to develop therapeutic systems against infections that occur due to the decreased immunity of cancer patients due to cancer treatment.

The present invention relates to an antimicrobial coating composition comprising, based on the total weight of the coating composition, 30-60% by weight of a polyester resin, 3-15% by weight of a curing agent, 0.1-5% by weight of an antimicrobial agent, 0.1-15% by weight of a pigment, and the balance being a solvent. The present invention further relates to an antimicrobial coated steel sheet comprising a steel sheet and an antimicrobial coating layer formed on at least one surface of the steel sheet, the antimicrobial coating layer containing an antimicrobial agent in at least a part thereof, the antimicrobial agent having a content ratio Z / (M+Ca) of 0.1-0.5, M being Ca, Ba, Mg, Zn, Ni, Fe or Al, and Z being P, As, V or Si. The antimicrobial coating composition according to the present invention contains an antimicrobial agent. When the composition forms a coating layer, the antimicrobial agent is concentrated on the surface of the coating layer, so that microorganisms adsorbed on the surface of the coating film together with moisture are effectively killed by hydroxyl radical species and hydroxide anions generated on the surface of the coating film. Thus, a coated steel sheet using the antimicrobial coating composition according to the present invention has excellent design properties as well as excellent processability, chemical resistance, etc.

A polypeptide corresponding to the amino acid sequence SEQ ID No 1, wherein said polypeptide has antimicrobial activity; An antimicrobial composition, comprising said polypeptide, and optionally a second antimicrobial agent and a carrier; Use of the antimicrobial composition to inhibit the growth and proliferation of Gram-positive and Gram-negative bacteria.

A solid material including a matrix, dispersed in which are microparticles of at least one antimicrobial agent for preventing, limiting and / or eliminating the contamination of the material and / or the contamination of a composition which is in contact with the material for at least a given time, and / or preventing, eliminating and / or slowing down the formation of biofilms on the surface of the material, wherein the antimicrobial agent is an oxide of at least one positively charged metal ion and the antimicrobial agent does not migrate out of the material. Also, the use of such material for manufacturing an article, to the process for manufacturing the article, and to the article obtained. In particular, the article is selected from stoppers, lids, seals, caps, covers, plugs and valves intended for sealing bottles, flasks, jars, cans, canisters, barrels, tanks, or various containers used for packaging and / or storing food products, dietetic products, cosmetic products, dermatological products or pharmaceutical products.

The present invention relates to a peelable wound dressing system configured to maintain a controlled wound environment while enabling repeated access for treatment. The system includes a flexible base layer adhered to skin and a transparent peelable cover affixed by a resealable attachment mechanism. The cover is configured for multiple peel-and-reseal cycles, permitting wound inspection and treatment without removing the base layer. Optional features include antimicrobial agents in the base layer, anti-fog treatments in the cover, perforations or catheters for exudate drainage, and access pathways for lavage, infusion, or drug delivery. In some embodiments, sensor networks and wireless communication circuits are integrated into the cover or base to monitor wound and skin parameters, with power supplied by micro-batteries, passive RFID / NFC, or energy-harvesting elements. These features collectively improve infection control, visualization, treatment access, monitoring, and extended wear, addressing critical unmet needs in human and veterinary wound care.

The present invention relates to an antimicrobial agent based on chitosan and zinc acetate for disinfection with prolonged bactericidal and virucidal activity, characterized in that it comprises: a) chitosan at a concentration of 500 ppm w / v; b) zinc acetate at a concentration of 300 ppm w / v; and c) an organic acid at a concentration of 100 ppm w / v; and in that said agent is diluted in water up to 16% while maintaining its antimicrobial properties.

Methods and systems are provided for infusing a crystalline and / or porous solid with a desired fluid, particularly an antimicrobial agent, as well as infused crystalline and / or porous solids produced thereby. Solids which may be infused with an antimicrobial agent according to the invention include erythritol, table salt, table sugar, baking soda, calcium carbonate, acetic acid, ascorbic acid, and marshmallow.

The invention provides antimicrobial composition comprising (a) a first active ingredient, wherein in the first active ingredient is selected from the group consisting of petroleum jelly, EpiCeram® emulsion, and / or glycerin, and (b) a second active ingredient selected from the group consisting of 1-octanoyl-rac-glycerol, 1-decanoyl-rac-glycerol, glycerol monolaurate (GML), rac-glycerol 1-myrstate, glycerol monocaprate, glycerol monocaprylate, glycerol monomyristate, or reutericyclin, wherein the second active ingredient is present at a concentration of 10 μg / ml to 100 mg / ml in the composition. The compositions are useful as antimicrobial agents.

The invention provides an antibacterial polyurethane film roll hole pricking device, and relates to the field of film hole pricking. The antibacterial polyurethane film roll pricking device comprises a bottom plate, a first supporting frame is fixedly connected to one side of the upper end of the bottom plate, a connecting column is rotationally connected to the upper end of the first supporting frame through a bearing, a mounting column is fixedly connected to one end of the connecting column, and a connecting block is slidably connected to one end of the mounting column; and a rotating roller is slidably connected to the interior of one end of the connecting block, two jackscrews are connected to the interior of the connecting block in a threaded mode, one ends of the two jackscrews abut against the mounting column and the surface of the rotating roller correspondingly, and a second supporting frame is fixedly connected to the side, away from the first supporting frame, of the upper end of the bottom plate. According to the film punching device, the bolts are used for connecting the mounting plates at the same time, the needle heads are connected into the mounting plates through the threaded heads, and the hole distance of film punching can be conveniently adjusted by increasing and decreasing the number of the mounting plates and the needle heads during use, so that the film punching device is suitable for punching requirements of different specifications, and the application range is wider.

This present invention is directed to antimicrobial fabric care compositions that provide detersive benefits such as stain and soil removal and aesthetic benefits like softening, wrinkle-reduction and color-protection and when used discretely or synergistically during the laundry program reduce the risk of infections and promote health and hygiene by providing dose-dependent antimicrobial activities such as sanitizing, disinfecting and removing malodors from fabrics, and imparting 24-48 hour antimicrobial-durability into fabrics, and deactivating biofilms inside the washing machine and preventing biofilm formation inside the washing machine to prevent recontamination of fabrics. The compositions are well-suited for use in domestic, commercial and on-premise-laundry-operations such as healthcare facilities, hotels, cruise ships, and the like. Methods for discrete and synergistic uses to simultaneously treat fabrics and the internal surfaces of the washing machine are also disclosed.

Disclosed are adhesive medical films incorporating one or more cationic steroidal antimicrobial (CSA) compounds. The adhesive medical film is in the form of a tape, dressing, or sheet, configured for contact against dermal tissue to provide securement of medical devices, wound care, wound closure, and / or scar prevention. The adhesive medical film includes (i) a polymer adhesive (e.g., pressure-sensitive adhesive) in which one or more CSA compounds are distributed, and (ii) optionally, a backing substrate upon which the polymer adhesive is disposed. Examples of polymer adhesives include polyacrylate and silicone adhesives. The adhesive medical films, when used, reduce microbial colonization and / or growth, both on the films during storage and at a dermal site, as compared to the same adhesive medical film without incorporated CSA compounds.

The utility model relates to the technical field of medicine delivery device, concretely to a kind of ureter delivery device suitable for antibacterial microsphere sustained release, including delivery structure and delivery pipe, delivery structure includes liquid storage cylinder, the left end of liquid storage cylinder is threadedly connected with cylinder cover, the left end of cylinder cover is equipped with connecting end, the input end of delivery pipe is equipped with the connecting sleeve threadedly connected with connecting end, piston for pushing antibacterial microsphere is equipped in liquid storage cylinder, the right side of piston is connected with push rod by bolt, the right end of push rod passes through the inner wall of liquid storage cylinder to outside, the lower portion of liquid storage cylinder is equipped with uniform speed drive structure for driving push rod left and right movement.The ureter delivery device suitable for antibacterial microsphere sustained release, the advancing speed of piston is controlled by uniform speed drive structure, and the physical speed-limiting effect of porous septum to microsphere passing is combined, antibacterial microsphere can be continuously released into urinary tract at constant and slow rate, overcome the problem of drug concentration sudden rise and sudden drop in traditional administration mode.

The invention provides novel compounds of formula (I), stereoisomers and pharmaceutically acceptable salts thereof: (wherein: Q is a lipophilic, zinc chelating moiety which is selective for Zn2+ ions; L1 is a covalent bond or a C1-6 alkylene chain in which one or more -CH2- groups of the alkylene chain are optionally replaced by a group independently selected from -CO- and -NR4- (where R4 is H or C1-3 alkyl); Y is selected from the following groups: (II) and (III) (where each R5 is independently H or C1-3 alkyl; and R6 is H or C1-3 alkyl); L2 is a covalent bond or a C1-6 alkylene chain in which one or more -CH2- groups of the alkylene chain are optionally replaced by a group independently selected from -CO- and -NR7- (where R7 is H or C1-3 alkyl); R is -OH, -O-C1-6 alkyl, -O-(CH2)p-O-CO-C1-6 alkyl (where p is an integer of 1 or 2) or -O-CH(CH3)-O- CO-C1-6 alkyl; each R1 is independently selected from halogen and C1-3 alkyl; each R2 is independently selected from halogen and C1-3 alkyl; R3 is H or C1-3 alkyl; n is an integer of 0 or 1; and m is an integer of 0 or 1). The compounds according to the invention are selective zinc chelators that find use as adjuvants in the treatment of bacterial infections and / or bacterial biofilms that harbour such infections. For use in such treatment, the compounds are used in combination with an antibacterial agent, for example a β-lactam antibiotic. The invention further provides a triple combination therapy for use in the treatment of bacterial infections and / or bacterial biofilms which comprises co-administration of the compounds to a subject in combination with a β-lactam antibiotic and a serine β-lactamase inhibitor.

This invention is related to the fields of medical biotechnology, nanobiotechnology, and nanomedicine. It involves a nanomedicine product that can release HOC1 (hypochlorous acid) at the tumor site in a controlled manner to treat lung cancer. HOC1 is a potent antimicrobial and antitumor agent that can target tumor tissues while minimizing damage to healthy tissues. The produced nanoparticles have a two-layer structure: the inner layer contains alginate, PFP (perfluoropentane), and Ca(OCl)2 to release HOC1, and the outer layer has a chitosan coating with folate and salicylic acid for targeting and proton release. The production process involves nanoemulsion and coating with the ionic gelation technique. When the nanoparticles are delivered to the lungs and targeted to cancer cells with folate, ultrasound radiation triggers the release of HOC1 to induce apoptosis and destroy cancer cells effectively, reducing side effects and improving treatment outcomes for lung cancer patients.