The invention belongs to synthetic anti-forgery ink of anti-counterfeiting materials, which is produced by mixing and specially processing commercial pigments, synthetic resin, vegetable oil, mineral oil, filling materials, additives and anti-counterfeiting materials, wherein the anti-counterfeiting materials include long-wave ultraviolet excitation fluorescence, short-wave ultraviolet excitation fluorescence, sunlight excitation color variable, infra-red excitation luminescence, thermochromism, chemical stain anti-counterfeiting materials, optical variable-hue, magnetism, DNA, invisible barcodes covering, intelligent potential and the like anti-counterfeiting materials. The synthetic anti-forgery ink of the invention is adaptable for various securities, bills, trademarks and the like, which has multiply anti-counterfeiting function. One time printing of the invention can achieve multiple anti-counterfeiting purposes. Further, the invention can satisfy identifying demands of different levels and has high anti-counterfeiting degree, which effectively increases anti-counterfeiting difficulty.