The invention relates to the field of medical instruments, in particular to an X-ray protection device with an integrated structure for an angiography machine. The device comprises a protection screen unit, a protection curtain unit and a bedside sliding rail unit, wherein the protection screen unit is arranged on the protection curtain unit, and the protection curtain unit is fixed on the bedside sliding rail unit so as to enable the protection curtain unit and the protection screen unit to synchronously and horizontally move along a bedside. The protection device can synchronously move along with a bed, and in a moving process, the protection device is always in the best protecting state and close to a patient, so that the problem that the radiation, especially the secondary stray radiation caused by the rays reflected by the patient, can not be effectively shielded due to the movement of the bed surface of a conduit bed is effectively solved, and meanwhile, the problems of prolonged surgery time, increased surgery risk and the like that are caused by adjusting the protection screen unit during surgery in the prior art are effectively avoided.