On-board ILS sensors for detecting illegal drugs and based on intracavity 
laser spectroscopy (ILS) are provided for detecting the presence of drugs and their metabolized by-product vapors in an enclosed space, such as a vehicle. The sensor comprises: (a) a 
laser comprising a 
gain medium having two opposed facets within a 
laser resonator and functioning as an intracavity spectroscopic device having a first end and a second end, the first end operatively associated with a partially reflecting (i.e., partially transmitting) surface; (b) a reflective or dispersive optical element (e.g., a mirror or a 
diffraction grating) operatively associated with the second end to define a 
broadband wavelength laser 
resonator between the optical element and the first end and to thereby define an 
external cavity region between at least one 
facet of the 
gain medium and either the first end or the second end or both ends; (c) the 
external cavity region being exposed to air in the enclosed space to enable any drugs or their metabolized by-product molecules to enter thereinto; (d) a 
detector spaced from the first end; (e) appropriate 
electronics for measuring and analyzing the 
detector signal; (f) a housing for containing at least the laser, the partially reflecting surface, and the optical element, the housing being configured to prevent escape of 
stray radiation into the enclosed space and to permit air from the enclosed space to continuously circulate through the 
external cavity region for analysis; and (g) means for driving the laser (e.g., electrical or optical). A method is provided for measuring concentration of 
drug vapors and their metabolized by-product vapors in the vehicle or other enclosed space employing the on-board sensor. The method comprises: (1) sensing any drugs and their metabolized by-product vapors in the enclosed space by the on-board sensor; and (2) providing a 
signal indicative of presence of any drugs or metabolized vapors.