225 results about "Drug detection" patented technology

The invention discloses a liquid medicine foreign matter detection method and system based on machine vision, and the method comprises the steps: obtaining multiband spectral data of a liquid medicine sample, and carrying out the normalization processing to generate a liquid medicine background standard spectral feature template; comparing the refractive index spectral characteristics of the template and the foreign matter-containing liquid medicine, and recording the surface roughness scattering mode and polarized light reflection angle change data of a foreign matter area; calculating a spectrum peak displacement quantized value according to the polarized light data, and extracting foreign matter edge spectrum gradient information in combination with a threshold value; calculating a transparency spectral attenuation coefficient based on the edge gradient information, and obtaining spectral contrast enhancement factors of different foreign matters in combination with the spectral response characteristic data; and if the enhancement factor does not reach the standard, adjusting the spectrum correction parameter and recalculating, fusing the scattering mode and the multi-angle incident spectrum response result to carry out consistency verification, and obtaining a final identification result containing the foreign matter material type and the danger level. The method can improve the drug detection accuracy and guarantee the drug quality safety.

The embodiment of the invention relates to the technical field of drug detection, in particular to an anti-CD38 antibody drug receptor occupation detection method and system, a peripheral blood sample is used for preparing a single-cell suspension, the single-cell suspension is divided into a TEST tube and an FMO tube, a cell surface antibody and an RO detection antibody are added into the TEST tube, only the cell surface antibody is added into the FMO tube, and only the RO detection antibody is added into the FMO tube. The TEST tube and the FMO tube are subjected to sample detection analysis, so that the average fluorescence intensity of RO detection antibodies of the TEST tube and the FMO tube is obtained. And performing RO detection analysis by adopting a dissociation method, taking the tubes which are not combined with the medicine as a total receptor group, taking the tubes which are combined with the medicine as a dissociation receptor group, and calculating an RO detection result according to the average fluorescence intensity of the TEST tube and the FMO tube.

Provided in the present invention is a method for detecting the fingerprint of an analgesic cream for knocks and falls, relating to the technical field of drug detection. The detection method comprises the following steps: preparing a test sample solution; preparing a reference sample solution; and injecting the test sample solution and the reference sample solution into a high performance liquid chromatograph, and recording the chromatogram. The method has the advantages of simplicity, stability, high precision, and good reproducibility. The method can conduct multicomponent fingerprint research on the analgesic cream for knocks and falls, and perform attribute research and similarity evaluation on main chromatographic peaks. The method comprehensively reflects the uniformity and stability of the analgesic cream for knocks and falls, and can evaluate, more comprehensively and scientifically, the quality of the analgesic cream for knocks and falls, thereby ensuring the quality and efficacy of the product.

The invention relates to the technical field of biological medicine, in particular to a drug screening model construction method based on airway organs, a model and application. The construction method of the drug screening model of the airway organoid comprises the steps of obtaining 2D airway epithelial cells, culturing the airway organoid, establishing an airway organoid inflammation model and / or establishing an airway organoid mucus secretion / goblet cell metaplasia model. Wherein the model is established according to the culture mode of the airway organ in cooperation with a specific stimulant for proliferation and differentiation. Compared with a traditional animal model, the organ-like model is low in cost and short in construction period, can better simulate the pathological process, can realize airway organ-like culture and establishment of an inflammation model and a mucus secretion / goblet cell metaplasia model at the same time, and has a good application prospect in drug detection of asthma and COPD diseases.

The invention provides a preparation method and drug detection application of ZIF-8-Fe metal organic framework nano-enzyme, the ZIF-8-Fe metal organic framework nano-enzyme is prepared by adopting a heating reflux method, and peroxidase-like activity and drug detection application of the ZIF-8-Fe metal organic framework nano-enzyme are researched. In the presence of H2O2, the material can catalytically oxidize TMB to generate a blue product and shows good peroxidase activity, and through optimization experiments, proper reaction temperature and pH buffer system and optimal concentrations of ZIF-8-Fe, TMB and H2O2 are determined. Kinetic analysis shows that the affinity of TMB is superior to that of natural HRP, and a colorimetric detection method is established based on the inhibition effect of TC on the catalytic reaction. The method disclosed by the invention is reasonable in linear range, relatively low in detection limit and good in sample recovery rate and relative standard deviation performance, can be used for detecting tetracycline tablets, and shows a potential application value of the ZIF-8-Fe nano-enzyme in the field of drug detection.

The application provides a method for detecting psychotropic drugs in environmental sludge based on acid pretreatment, which comprises the following steps: S1: obtaining a sludge sample to be detected, performing pressurized fluid extraction on the sludge sample to be detected after freeze-drying to obtain an extraction solution, performing solid-phase extraction on the extraction solution to obtain an eluate, and redissolving the eluate to obtain a solution to be detected, wherein the pressurized fluid extraction is performed under the condition of 5 ‰ formic acid water without heating; and S2: performing liquid chromatography mass spectrometry on the solution to be detected to obtain a mass spectrum, wherein the psychotropic drug is one of eptazocine, codeine, AMP, MAMP, MDA, monoacetylmorphine, MDMA, PMMA, fentanyl, norfentanyl, ketamine, norfentanyl, benzoyl eptazocine, cocaine and tramadol, and the method realizes detection of multiple psychotropic drugs in environmental sludge.

The invention belongs to the technical field of drug detection, and particularly relates to a method for detecting lycium barbarum glycopeptide metabolites in rat plasma and tissues based on non-targeted metabonomics. According to the method, after rat lycium barbarum glycopeptides are administered through intragastric administration, blood, liver, intestine, lung and brain tissue samples after administration are collected. A UPLC-Q-TOF-MS (Ultra Performance Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry) analysis method is combined with a statistical analysis method comprising principal component analysis (PCA) and orthogonal-partial least squares discriminant analysis (OPLS-DA) to carry out in-vivo metabonomics analysis on the wolfberry glycopeptide. Then, based on a human metabolome database (HMDB), lycium barbarum glycopeptide differential metabolite is searched, so that the pharmacological action mechanism of the lycium barbarum glycopeptide is clarified from the perspective of metabolism, and a foundation is laid for deep research and development of the medicinal value of the lycium barbarum glycopeptide in future.

The invention discloses a method for determining related substances in a loxoprofen sodium patch in the technical field of drug detection, and aims to solve the technical blank existing in determination of related substances in a loxoprofen sodium patch in the prior art. The method comprises the following steps: respectively weighing a loxoprofen sodium reference substance and an impurity reference substance, and adding a solvent for dilution to prepare a reference substance solution; taking a loxoprofen sodium patch, stripping a protective layer, adding tetrahydrofuran and methanol, shaking to separate the paste from a backing layer, adding water, shaking again, adding a solvent for dilution, uniformly mixing, centrifuging, and taking supernate to obtain a test solution; injecting the prepared reference substance solution and the test solution into a high performance liquid chromatograph for determination to obtain peak areas of the reference substance solution and the test solution; and calculating the content of the related substances in the loxoprofen sodium patch by adopting an HPLC correction factor method according to the peak areas of the reference solution and the test solution. The method is suitable for measuring the content of the related substances in the loxoprofen sodium patch.

The invention relates to a detection method of a revivacin inhalation solution, and belongs to the technical field of medicine detection. According to the detection method provided by the invention, a revivin inhalation solution sample is analyzed by adopting high performance liquid chromatography to obtain the content of impurities in the revivin inhalation solution; the high performance liquid chromatography uses a phosphate buffer as a mobile phase A and acetonitrile as a mobile phase B, and the elution conditions are as follows: 0-5 min, the volume ratio of the mobile phase A to the mobile phase B is gradually changed from 95: 5 to 80: 20; the volume ratio of the mobile phase A to the mobile phase B is gradually changed from 80: 20 to 20: 80 in 5-30 min; the volume ratio of the mobile phase A to the mobile phase B is 95: 5. The method provided by the invention can realize accurate detection of five different impurities in the revienacin inhalation solution, and is beneficial to actual production quality control and improvement of drug safety.

The invention relates to the technical field of drug detection, in particular to a molecularly imprinted sensor for quantitatively detecting olanzapine in human blood as well as a preparation method and application of the molecularly imprinted sensor. Au-Pt NSF is deposited on the surface of a substrate electrode through an HBDT method, then a molecularly imprinted polyaniline layer is prepared through electro-polymerization, and the molecularly imprinted sensor is formed. A classical redox probe potassium hexacyanoferrate is used as a tool, and DPV is used for monitoring current change (delta I) caused by olanzapine addition, so that sensitive quantitative detection of olanzapine is realized. The sensor prepared by the invention shows a good linear relationship to olanzapine in the concentration ranges of 0.005-0.4 mu M and 0.4-10 mu M, the detection limit is 0.94 nM, and the sensor has high reproducibility and stability (relative standard deviation RSDlt;

The invention belongs to the technical field of medicine detection, and particularly relates to dipropyl malonic acid prepared by a dimethyl malonate method and a detection method of impurities of the dipropyl malonic acid. According to the detection method provided by the invention, the dipropyl malonic acid prepared by a dimethyl malonate method and impurities thereof are detected through high performance liquid chromatography (HPLC) for the first time; the impurities comprise propyl malonic acid, 2-methyl-2-propyl malonic acid, 2-propyl-2-butyl malonic acid, propyl malonic acid monomethyl ester, 2-methyl-2-propyl malonic acid monomethyl ester, dipropyl malonic acid monomethyl ester, 2-propyl-2-butyl malonic acid monomethyl ester, propyl malonic acid dimethyl ester, dipropyl malonic acid monopropyl ester and propyl malonic acid dimethyl ester; the invention relates to a method for preparing dipropyl malonic acid, which is selected from one or more of dipropyl malonic acid dimethyl ester, dipropyl malonic acid methyl ester propyl ester and 2-propyl-2-butyl malonic acid dimethyl ester, and solves the problems of quality control and process evaluation of dipropyl malonic acid serving as an intermediate of sodium valproate prepared by a dimethyl malonate method.

The invention relates to the technical field of data processing, in particular to a pharmaceutical production whole-process quality tracing method and system applying a block chain technology, and the method comprises the steps: obtaining a liquid matrix composed of pixel values of a liquid region in an injection bottle; obtaining an effective test region in the liquid matrix by using a region growth method; processing the pixel value of the effective test area to obtain an enhanced matrix; training a recognition network to recognize impurity types in the enhancement matrix; acquiring an enhanced matrix in the production process, and identifying whether impurity types exist or not by using the trained identification network; and in response to the existence of the impurity type, prompting related personnel to perform quality inspection on the corresponding production process. The method has the effects of improving the drug detection accuracy and providing a reliable data basis for subsequent drug traceability.

This invention discloses an intelligent batch dispensing device for mother liquor powder, comprising: a dispensing frame assembly including a first accommodating part and a second accommodating part; a frame rotation assembly including a rotation drive assembly and a rotation mounting base; a first feeding mechanism including a powder bottle feeding assembly and a powder bottle translation assembly; and a second feeding mechanism including a mother liquor bottle feeding assembly and a mother liquor bottle translation assembly. According to this invention, the intelligent batch dispensing device for mother liquor powder saves dispensing space due to the vertical arrangement of the first and second accommodating parts; a drug detection device is provided to read and identify the fixture and drug information; and the frame rotation assembly drives the rotation of the dispensing frame assembly, enabling the powder bottle translation assembly or the mother liquor bottle translation assembly to dispense the drug quickly and accurately, thereby improving dispensing efficiency.

We provide a flexible, AI-powered wearable patch system for non-invasive medication compliance monitoring. [Solution] This system 100 integrates physiological sensors 101 to detect heart rate variability, skin temperature, electrocutaneous activity, and swallowing-related muscle signals. A drug detection sensor 102 identifies interactions with drug containers, and a medication event sensor 103 detects gestures or physiological signals indicating medication. An embedded AI processor 104 receives multimodal sensor data and performs digital filtering, normalization, artifact removal, and machine learning-based classification to determine medication confirmation events, missed doses, or irregular medication patterns. A power management unit 105 controls the power supply to ensure continuous operation. A wireless communication module 106 transmits processed medication data to an external device. This enables reliable, objective, and real-time medication confirmation without relying on invasive ingestion sensors or patient reports.

The invention relates to the technical field of drug detection and analysis, in particular to a diiodide detection method, dichloromethane-acetone-methanol-ammonia water (7: 1: 1: 1) is used as a developing solvent, the concentration of diiodide in reaction liquid during nitration reaction of diiodide in the lobaplatin production process is detected, the method can accurately judge whether nitration reaction is complete or not, and the detection result is accurate. And the diiodide is ensured to be completely reacted in the nitration reaction process. The obtained method is suitable for detecting and judging the lobaplatin nitration reaction endpoint, the result is accurate and reliable, good specificity, durability and solution stability are achieved, and the detection time is short.

1. The name of the design product: drug detector. 2. The use of the design product: for drug detection. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: combination state reference figure 2.

This application discloses a portable drug detection device and method, relating to the field of drug identification technology, with the main objective of addressing the problem of poor detection effectiveness in existing drug testing methods. It includes: a Raman spectroscopy component, an ion mobility spectrometry component, a processor, a power module, a display component, and a sample inlet module disposed on the ion mobility spectrometry component. The processor is electrically connected to the Raman spectroscopy component, the ion mobility spectrometry component, and the display component, and is used to identify and process the spectra acquired by the Raman spectroscopy component and the ion mobility spectrometry component to obtain drug detection results. The power module is electrically connected to the Raman spectroscopy component, the ion mobility spectrometry component, and the processor, and is used to provide power. The display component is used to display the drug detection results. The sample inlet module is used to insert sample test strips.

The utility model provides a titration device for medicine detection, which belongs to the technical field of titration detection and comprises a clamping mechanism arranged in an inner cavity of a base, a pull rope fixedly connected to one end of a pull rod, a winding disc arranged at the other end of the pull rope, a first bevel gear fixedly connected to the bottom of the winding disc, and a support shaft fixedly mounted at the bottom of the first bevel gear, the torsional spring and the first bevel gear are arranged on the outer surface of the supporting shaft in a sleeving mode, the supporting shaft rotates, the first bevel gear drives the second bevel gear, the rotating shaft and the spiral guide roller which are meshed with the first bevel gear to rotate, and the first bevel gear moves left and right on the surface of the spiral guide roller along with rotation of the spiral guide roller to drive the clamping rod to clamp the conical flask. According to the utility model, the conical flask can be effectively clamped and fixed through the matching of all parts between the clamping mechanisms, and the problems that the conical flask is easy to turn over or slide down due to the fact that the conical flask cannot be fixed during titration in the prior art, so that personnel need to prepare materials again, time and energy are wasted, and the working efficiency is delayed are solved.

The invention belongs to the technical field of medicine detection, particularly provides a GC method for rapidly identifying rhizoma dryopteris crassirhizomae and fake rhizoma dryopteris crassirhizomae, and particularly discloses application of trans-nerolidol in identification or auxiliary identification of rhizoma dryopteris crassirhizomae and fake rhizoma dryopteris crassirhizomae. Compared with the prior art, the method provided by the invention has the advantages that the content in the male fern rhizome is lower, the content in other male fern rhizome fake products is lower, the male fern rhizome can be used as the marker, and a male fern rhizome identification method is established, has a better linear relation, has specificity and is good in instrument precision, stability, repeatability and reproducibility; the quantitation limit of the trans-nerolidol is 0.139 mu g / ml, and the detection limit is 0.046 mu g / ml; the trans-nerolidol content of 32 batches of cyrtomium rhizome samples is 0.11%-1.39%, the trans-nerolidol content of rhizoma dryopteris crassirhizomae should not be less than 0.25%, and a more accurate method is provided for identification and quality control of rhizoma dryopteris crassirhizomae.

The utility model discloses a rapid hair sampling device for drug detection. The rapid hair sampling device comprises a scissor body I, a scissor body II, an adjusting structure and a hair extension structure, a gap is formed between the second scissor body and the first scissor body, the adjusting structure is arranged between the first scissor body and the second scissor body, and the hair receiving structure is arranged at the bottom of one side of the first scissor body and the bottom of one side of the second scissor body. Compared with the prior art, the device has the advantages that the threaded rod is rotated through the rotating block, then the second hinge shaft is driven to move, the size of the gap between the second scissor body and the first scissor body is adjusted, the hair cutting length can be adjusted conveniently according to the drug detection requirement, and due to the fact that the first scissor body and the second scissor body act synchronously, the structure is simple, and operation is convenient. The length consistency of the clipped hair samples is high, the accuracy of drug detection results can be improved, the whole hair sampling process is easy and convenient to operate, and the sampling efficiency is high.

The application discloses a quality detection method for a compound phyllium panax schisandra preparation, and belongs to the technical field of drug detection and analysis. The traditional Chinese medicine is composed of phyllium, panax and schisandra. Qualitative analysis is conducted on the phyllium, panax and schisandra in the compound by using a thin layer chromatography method; and the contents of gallic acid, ginsenoside Rg1 and schisandrin A in the compound are determined by using a high performance liquid chromatography method. The thin layer chromatography method is one of classical traditional Chinese medicine analysis methods, and has the advantages of rapidness, convenience and the like; the high performance liquid chromatography method is also one of classical traditional Chinese medicine analysis methods, and has the advantages of mature technology, good stability, high universality and the like, can be used for widely and accurately detecting chemical components in a complex traditional Chinese medicine compound, the content determination method passes the method validation, has good linear relationship, and the precision, stability, repeatability and recovery rate meet the regulations, and the combination of qualitative analysis and quantitative analysis lays a foundation for establishing the quality standard of the compound preparation.

The invention discloses an aripiprazole raw material particle size detection method, and belongs to the technical field of drug detection. Technical breakthrough is realized through specific detection instrument type selection, key parameter optimization and system verification process construction: a new ParaThak laser particle analyzer equipped with an R5 measuring lens, an RODOS / M dispersion system and a VIBRI sample injector is selected, a standardized parameter system with dispersion pressure of 3.0 Bar, a sample injection rate of 70% and optical concentration of 5%-10% is determined, and the measurement accuracy of the system is improved. A complete detection process is formed through sample amount exploration, repeatability and precision verification. According to the present invention, with the core idea of determining the optical concentration control standard, optimizing the sample amount matching concentration and verifying the reliability of the method, the problem of poor optical concentration repeatability is solved, the stability and the accuracy of the detection data are significantly improved, and the reliable detection means is provided for the quality control of the aripiprazole raw material.

The invention discloses a cysteine impurity as well as a quality control method and application thereof, and belongs to the technical field of drug detection. The technical problem to be solved is to provide a cysteine quality control method for impurities generated after terminal sterilization of cysteine. The key point of the technical scheme is that the structural formula of the cysteine impurity 1 is shown in the specification.

The invention provides a metabolic marker combination for identifying okra related species, an identification method and application of the metabolic marker combination, and belongs to the technical field of drug detection. The identification method provided by the invention comprises the following steps: carrying out non-targeted metabonomics detection on dry powder samples of Abelmoschus manihot (L.) Medik., Abelmoschus moschus (L.) Meduli, Abelmoschus sagittifolius (L.) Merr. And Abelmoschus esculentus (L.) Moench by adopting ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS / MS), so as to obtain metabolite data, and carrying out quantitative analysis on the metabolite data, so as to obtain a sample of the Abelmoschus manihot (L.) Meduli, the sample of the Abelmoschus moschus (L.) Merr. And carrying out mass spectrum qualitative and quantitative analysis on metabolite data, and screening out common differential metabolites among the four plants as characteristic metabolites to realize variety identification of okra related species. The method can effectively distinguish okra species with similar morphologies, and has application value in traditional Chinese medicinal material original identification, germplasm resource screening and variety purity detection in a seedling raising stage.

The invention provides a medicine content detection method combining a respiration simulation device and HPLC (High Performance Liquid Chromatography), which relates to the technical field of medicine detection and comprises the following steps: establishing a mathematical expression of a target medicine net peak area and a target medicine concentration under each respiration parameter combination and a mapping relation between the respiration parameter combination and a target medicine reference peak area; therefore, the target drug net peak area of the to-be-detected gas is determined, a plurality of similar breathing parameter combinations similar to the breathing state under the current breathing parameter combination are screened out, and the accurate value of the target drug concentration of the to-be-detected gas is determined by combining the corresponding confidence coefficient, so that the accuracy of the detection result is ensured, and the detection efficiency is improved. A mathematical expression for solving the target drug concentration under the current breathing parameter combination is established without multiple calibration tests, so that the workload is greatly reduced, and the drug concentration detection efficiency is improved.

The utility model relates to the technical field of medicine detection, and discloses a microorganism quantitative culture medium platform for medicine detection, which comprises an incubator, a culture cavity is arranged on the right side of the inner wall of the incubator, a separation mechanism is arranged on the inner wall of the culture cavity, and a sealing mechanism is arranged on the front side of the outer wall of the culture cavity. An ultraviolet lamp is fixedly connected to the front side of the top of the inner wall of the culture cavity, adjusting mechanisms are arranged on the periphery of the bottom of the culture box, and a controller is fixedly connected to the left side of the inner wall of the culture box. And the separation mechanism comprises a plurality of placing plates. According to the utility model, the placing plate, the heating wire, the temperature detector and the humidity detector are matched with the controller, the temperature and the humidity are accurately regulated and controlled, the microorganism culture condition is met, the culture dish is independently drawn and pulled, and the torque spring and the baffle are matched, so that the culture dish is prevented from falling off and microorganism pollution is avoided; the problem of microorganism cross contamination caused by cover plate movement in the prior art is solved.

The invention belongs to the technical field of medicine detection, and particularly relates to a high performance liquid chromatography detection method for dipropylmalonic acid and impurities thereof. The method comprises the following steps: preparing a to-be-detected sample into a test solution; the to-be-detected sample is dipropyl malonic acid prepared by adopting a diethyl malonate method and impurities of the dipropyl malonic acid; and detecting the test solution by adopting a high performance liquid chromatography method to obtain a detection result of dipropylmalonic acid and impurities thereof in the sample to be detected. According to the detection method provided by the invention, the detection of dipropylmalonic acid prepared by adopting a diethyl malonate method and impurities thereof is realized through high performance liquid chromatography (HPLC) for the first time, and the problems of quality control and process evaluation of the dipropylmalonic acid prepared by adopting the diethyl malonate method, which is an intermediate of a sodium valproate raw material medicine, are solved; therefore, detection and control of impurities (including 2-ethyl valeric acid) in the sodium valproate raw material medicine are realized.

The utility model discloses a residual drug detection device for animal-derived food, which relates to the technical field of detection devices and comprises a drug detection equipment box, a detection chamber is arranged at one end of the top of the drug detection equipment box, and a glass cover is movably mounted at one end of the detection chamber. A control display screen is fixedly installed at the other end of the top of the medicine detection equipment box, a carrying plate is movably installed in the detection chamber, a feeding plate is movably installed at the top of the carrying plate, and limiting mechanisms are arranged on the two sides of one end of the feeding plate. Through mutual cooperation of the baffle, the limiting groove, the movable push block, the connecting plate, the springback column and the spring, the movable push block is manually pushed to move towards the outer side, so that the connecting plate is driven to move out of the limiting groove, the baffle loses the limiting acting force, the top plate and the baffle are pushed in cooperation with the springback force of the springback column and the spring, one end of the baffle is tilted, and the baffle is fixed. Workers can conveniently disassemble and replace the baffle, and better detection of the device is facilitated.

The utility model relates to the technical field of medicine detection equipment, and discloses analysis equipment for online medicine detection, which comprises a support table, a medicine analysis equipment main body arranged on the upper surface of the support table, and a first electric push rod fixedly arranged on the upper surface of the support table, according to the analysis equipment for drug online detection, frequent manual cleaning steps are eliminated through an automatic cleaning system, the time required for cleaning is greatly shortened, and therefore the overall efficiency of drug detection is improved, the labor intensity of workers is reduced, and the detection efficiency is improved. According to the automatic cleaning process, the workload of operators is reduced, the labor intensity is reduced, the operators can put more energy into other key tasks, the cleanliness of the liquid storage detection box is ensured, the risks of personal errors and cross contamination are reduced, and the accuracy and consistency of detection results are improved.

The invention discloses a test strip for detecting fluoroquinolones, sulfonamides, tetracyclines and trimethoprim drug residues in aquatic products and a test method, and belongs to the technical field of drug detection.The preparation method comprises the steps that trimethoprim hapten is synthesized; synthesizing a quinolone hapten, a sulfanilamide hapten and a tetracycline hapten; preparing an immunogen and a coating antigen; preparing a monoclonal antibody; preparing a gold-labeled antibody; and pre-treating and assembling. According to the invention, an integrated detection scheme of four types of medicines is constructed, so that residual detection of fluoroquinolones, sulfonamides, tetracyclines and trimethoprim in aquatic products can be synchronously completed, and different detection tools or batch detection for single type of medicines is not needed. In an actual detection scene of aquatic products, repeated steps of sample treatment and detection operation can be greatly reduced, waste of aquatic product samples caused by repeated sampling is avoided, meanwhile, the overall detection period is shortened, and the rapid quality control requirement of the aquatic products from fishing / breeding to circulation links is met.