Rapid preparation method of regular triangular pyramid SERS active substrate

A positive triangle and active base technology, which is applied in the field of high-sensitivity SERS sensor active substrates and its preparation, can solve the problems affecting the detection sensitivity and performance of drug detection systems, difficulties, etc., achieve good application prospects, reduce dosage, and have good reproducibility Effect

Inactive Publication Date: 2013-11-20
苏州扬清芯片科技有限公司
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The quality of the active substrate can lead to a difference in the detection concentration level of even more than 10,000 times, which will greatly affect the detection sensitivity and performance of the drug detection system
The active basal SERS enhancement factors reported today are basically in the range of 10 6 Level, there are still some difficulties in ultra-sensitive detection of trace drugs

Method used

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  • Rapid preparation method of regular triangular pyramid SERS active substrate
  • Rapid preparation method of regular triangular pyramid SERS active substrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A single layer of 200nm polystyrene microspheres was spread on the surface of the Si substrate, and a 100nm gold film was thermally evaporated on the surface of the polystyrene-modified substrate, and then the substrate was placed in an absolute ethanol ultrasonic solution for 2 Minute treatment to remove the polystyrene microspheres to obtain a SERS active substrate.

Embodiment 2

[0021] Spread 100nm polystyrene microspheres in a single layer on the surface of a conductive glass substrate, thermally evaporate a 100nm silver film on the surface of the polystyrene-modified substrate, then place the substrate in an absolute ethanol ultrasonic solution, and ultrasonically After 2 minutes, the polystyrene microspheres were removed to obtain a SERS active substrate.

Embodiment 3

[0023] Spread 300nm polystyrene microspheres in a single layer on the surface of a conductive glass substrate, thermally evaporate a 200nm copper film on the surface of the polystyrene-modified substrate, and then place the substrate in a carbon tetrachloride ultrasonic solution, Ultrasonic treatment for 2 minutes removed the polystyrene microspheres to obtain a SERS active substrate.

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Abstract

Belonging to the technical field of laser Raman spectroscopy and trace drug detection, the invention in particular relates to a high sensitivity SERS (furface enhanced Raman scattering) sensor active substrate for drug detection and a preparation method thereof. The regular triangular pyramid SERS active substrate provided in the invention is a noble metal nano-pyramid array structure coated on a base chip. The noble metal material can be silver, copper and/or gold. The high sensitivity SERS sensor active substrate provided in the invention has surface enhanced Raman activity and high repetition rate, and can be used for detection of trace compounds such as drugs, explosives and the like.

Description

technical field [0001] The invention belongs to the technical field of laser Raman spectroscopy and trace toxic and harmful inorganic small molecule detection, and specifically relates to a high-sensitivity SERS sensor active substrate for detecting drugs and a preparation method thereof; more specifically, the invention relates to a Surface-enhanced Raman activity, high repetition rate, high-sensitivity SERS sensor active substrate that can be used for detection of trace compounds such as drugs and explosives, and a preparation method thereof. Background technique [0002] As a common method for analyzing molecular vibrational spectra, laser Raman technology has been widely used in the fields of identifying the molecular structure of substances and analyzing the surface binding state. However, the Raman effect signal is often very weak. When the concentration of the measured molecule is small, or when the surface adsorbed substance is detected, the conventional laser Raman ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
Inventor 浦鹏董明建
Owner 苏州扬清芯片科技有限公司
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