56 results about "Narcotic" patented technology

The invention discloses a benzodiazepine # imgabs0 # compound with a structure as shown in a formula I or a pharmaceutically acceptable salt, a stereoisomer, a tautomer, a polymorphic substance, a solvate, a metabolite or a prodrug of the benzodiazepine # imgabs0 # compound. The benzodiazepine # imgabs 1 # compound disclosed by the invention has the characteristics of low toxicity, high safety, quick action, short action time, stable anesthesia, quick metabolism, quick reviving and the like. The invention further discloses application of the benzodiazepine # imgabs2 # compound or pharmaceutically acceptable salt, stereoisomer, tautomer, polymorphic substance, solvate, metabolite or prodrug thereof in preparation of sedative or anesthetic drugs, and further discloses application of the benzodiazepine # imgabs2 # compound or pharmaceutically acceptable salt, stereoisomer, tautomer, polymorphic substance, solvate, metabolite or prodrug thereof in preparation of sedative or anesthetic drugs. # imgabs3 #

The invention discloses a dexmedetomidine and propofol combined reagent and a combination method, and relates to the technical field of combined use of anesthetic drugs. According to the method, firstly, dexmedetomidine is subjected to intravenous pump injection within 5-15 minutes according to the dosage of 0.5-1.0 mu g / kg, propofol is given within 2 minutes after the dexmedetomidine is subjected to general anesthesia, and the dosage of the propofol can be reduced by 10%-50% compared with that of propofol which is independently used. Through pretreatment of dexmedetomidine, the anesthetic effect of propofol can be enhanced, adverse reactions such as blood pressure drop and respiratory depression can be effectively reduced, and anesthetic safety and controllability are improved. The combined reagent comprises independent containers for respectively loading the dexmedetomidine injection and the propofol emulsion, and can be packaged by adopting a double-cavity pre-filled injector, and sequential injection is realized through a controllable opening mechanism, so that unstable emulsification and titer change caused by physical mixing of medicines are avoided.

The invention provides an etomidate derivative, a preparation method thereof and application of the etomidate derivative in preparation of anesthetic drugs, and belongs to the field of chemical medicines. The structure of the etomidate derivative is shown as a formula I in the specification. Compared with etomidate, the compound disclosed by the invention has the advantage that the anesthesia time is remarkably shortened. The anesthesia time is shortened, so that some side effects after anesthesia can be relieved; rapid recovery of the autonomous regulation ability of important organs of a patient and postoperative nursing are facilitated; and the risk of wake-up delay is reduced. The etomidate derivative provided by the invention has a good application prospect in preparation of anesthetic drugs for shortening anesthesia time. And # imgabs0 #.

The application discloses a monitoring and regulation system and method for an anesthesia maintenance period, and the system comprises: a database for storing vital sign data and drug injection data of the whole process of the anesthesia maintenance period; and an anesthesia auxiliary platform configured with a monitoring and regulation model, which is used for intelligent regulation of an anesthesia cycle in the anesthesia maintenance period and provision of an anesthesia maintenance strategy. The application performs real-time monitoring on basic life functions of a human body in the anesthesia maintenance period, combines an anesthesia drug artificial intelligence intelligent regulation model, intelligently evaluates anesthesia risks, and intelligently regulates the dosage of anesthesia drugs, which is beneficial to control of anesthesia quality, can achieve optimal anesthesia effect by using the least anesthesia drugs, and shortens the postoperative recovery time.

The invention discloses anesthetic grinding equipment which comprises a storage barrel, a feeding assembly, a grinding assembly and a collecting assembly, a cover plate is fixedly connected to the top end of the storage barrel, a grinding knob driven by a motor is arranged at the axis of the top end of the cover plate, and limiting rods are fixedly connected to the two sides of the inner contour of the storage barrel. A feeding port is formed in the outer contour of the side, close to the top end, of the storage barrel. By arranging the feeding assembly, medicine to be ground is pushed and extruded while adding of the medicine is completed, and then the situation that the grinding effect is reduced due to rigid contact collapse of the medicine in the grinding process is avoided; by arranging the grinding assembly, the grinding degree can be freely adjusted while medicine grinding is achieved, and then the medicine grinding requirements in different scenes are met; and by arranging the collecting assembly, the grinding assembly is continuously knocked to reduce powder attachment while the ground medicine powder is collected, and then the grinding error of the equipment is reduced.

1. Name of the designed product: anesthetic tray. 2. Use of the designed product: anesthetic tray for use in surgery. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

To provide a count bag capable of easily checking at a glance and managing the residual number of medicines such as medical narcotic prescribed to each patient.SOLUTION: In a count bag, pocket sheets are regularly arrayed in a form of multiple rows and n columns on a surface side of a sheet body forming a base plate using a resin film or the like, a plurality of first pockets having one end opened, fixed to the sheet body in a bag shape, and storing an unused medicine, each bag is numbered with a natural number in a residual number display part such that the residual number can be easily checked at a glance, a free description space where a medicine name, a patient name, a day, or the like can be described with a writing utensil, a second pocket part having one end opened capable of storing used narcotic collection sheet and an unopened medicine, and the count bag is of sheet-type three types (for patch, for rescue medicine, and for medicine sheet).SELECTED DRAWING: Figure 1A

The present application relates to the field of narcotic drug concentration regulation, and relates to an inhaled narcotic drug administration concentration analysis and evaluation method. First, according to the basic physiological data, the past anesthesia sensitivity and the operation information and other characteristic data of the patient, the initial administration concentration is obtained by using the fuzzy matching algorithm; the physiological sign data such as blood pressure, heart rate, pulse blood oxygen saturation and end-tidal carbon dioxide partial pressure of the patient are monitored in real time during the anesthesia process and compared with the normal range, whether it is abnormal is judged and the adjustment scheme of the administration concentration is determined according to the administration concentration-physiological sign correlation model; the anesthesia depth is evaluated by monitoring the electroencephalogram double frequency index after adjusting the administration concentration, and the adjustment effect is judged by analyzing the anesthesia depth coincidence degree, so as to realize the closed-loop control of the administration concentration of the narcotic drug. The method can accurately regulate the administration concentration, optimize the concentration adjustment mechanism, effectively improve the safety and effectiveness of the anesthesia process, and provide reliable protection for clinical anesthesia.

The present invention relates to an optical sensing element for detection of a narcotic, the optical sensing element comprising a fluorescent sensing compound provided on a substrate, wherein emission of the fluorescent sensing compound is quenched in the presence of the narcotic, and wherein the fluorescent sensing compound is non-polymeric and comprises an electron donor moiety, an electron acceptor moiety and a moiety that influences solubility of the compound in a solvent. Sensing devices incorporating the sensing element and methods of detecting narcotics are also described.

According to the technical scheme, the poison and anesthesia medicine management table comprises a table body, the upper end of the table body is provided with a plurality of first inner cavities with upward openings, a round barrel is provided with a second inner cavity with an upward opening, the lower end of the round barrel is provided with a plurality of shaft rods, the bottoms of the first inner cavities are provided with sliding grooves for the shaft rods to stretch into, and the first inner cavities and the second inner cavities are communicated through the sliding grooves. A spring is wound on the shaft rod, a plugging cover is arranged on an upper opening of the first inner cavity in a matched mode, labels are pasted on the transverse plates, a transparent window is arranged on the table body and corresponds to one transverse plate, a plurality of outlets are formed in the side face of the table body, and through holes corresponding to the outlets are formed in the bottom of the round barrel. Different kinds of toxic anesthetics are placed into the second inner cavity from the upper opening of the first inner cavity, meanwhile, due to the fact that the placed toxic anesthetics have certain weight, the spring is pressed downwards, the transverse plate on the side face of the spring moves downwards, and when the toxic anesthetics need to be taken out, the toxic anesthetics stretch into the second inner cavity from the outlet to be taken out.

The invention relates to the technical field of medical instruments, and particularly discloses an anesthetic medicine and anesthetic syringe management device and an anesthetic medicine management system.The anesthetic medicine and anesthetic syringe management device comprises a container, a cover body, a medicine storage part, an identification module, an electronic lock, a driving device and a control device; the container and the cover body are locked through the electronic lock and the clamping groove, the container is provided with a containing groove, the cover body is provided with a medicine outlet, and the medicine outlet is communicated with the containing groove; a rotating disc and a lifting device are arranged in the container, an output shaft of the driving device is connected with the rotating disc, and a through hole is formed in the bottom of the medicine storage piece; the control device is used for controlling the electronic lock, the driving device and the lifting device at least according to the identification information of the identification module; the anesthetic and anesthetic syringe management device replaces manual management of anesthetic and anesthetic-containing syringes.

The invention relates to the technical field of anesthetic drugs, in particular to an application for surface anesthesia and a preparation method thereof. The patch for surface anesthesia comprises a base material layer, an anesthesia layer and an isolation layer which are arranged in sequence, the anesthesia layer is prepared from the following components in parts by weight: 5 to 10 parts of anesthetic, 1 to 3 parts of piceatannol, 0.5 to 2 parts of ligustralactone, 15 to 25 parts of polyvinyl alcohol, 1 to 5 parts of chitosan, 0.3 to 0.5 part of thickening agent, 5 to 10 parts of transdermal absorbent and 50 to 60 parts of purified water. The patch for surface anesthesia can be applied to the surface of skin, can quickly permeate into the skin, and has the characteristics of quick anesthesia effect, longer anesthesia duration and the like. In addition, the application also has the advantages of excellent antibacterial activity, high safety, simplicity and convenience in use and the like.

The application provides a method, system, device and medium for determining anesthesia consciousness, which comprises: obtaining a target electroencephalogram signal of a target object; determining consciousness state information of the target object based on the target electroencephalogram signal through a consciousness determination model, wherein the consciousness state includes a conscious state, a light anesthesia state and an unconscious state; wherein the consciousness determination model is a machine learning model, and the consciousness determination model is obtained based on training samples, wherein the training samples include sample electroencephalogram signals, and the sample electroencephalogram signals include sample conscious state data, sample light anesthesia state data and sample unconscious state data. Through the trained consciousness determination model, the change in anesthesia depth of the target object during the operation and the smooth transition thereof can be accurately tracked on the basis of accurately determining the unconscious state or the non-unconscious state of the target object, so that the regulation of the amount of anesthetic drugs for the target patient during the operation is more accurate.

The invention relates to the technical field of clinical anesthesia, in particular to a drug supply anesthesia system for a clinical anesthesiology department, which comprises a data acquisition module, a drug management module, an identity authentication module, an emergency management module and a record report module. By adding the taboo compatibility information in the establishment process of the drug analysis model, the drug supply anesthesia system can identify the possible interaction between the anesthetic and other drugs, so that side effects or adverse reactions caused by improper combination use are avoided.

The invention provides an etomidate derivative as well as a preparation method and application thereof, and belongs to the field of chemical medicines. Compared with etomidate, the etomidate derivative disclosed by the invention has the advantage that the anesthesia time is remarkably shortened. The anesthesia time is shortened, so that some side effects after anesthesia can be relieved; rapid recovery of the autonomous regulation ability of important organs of a patient and postoperative nursing are facilitated; and the risk of wake-up delay is reduced. The etomidate derivative provided by the invention has a good application prospect in preparation of anesthetic drugs for shortening anesthesia time.

The invention provides a device for automatically and quantitatively proportioning anesthetics, and relates to the technical field of medicament proportioning equipment. Comprising a proportioning assembly and a mixing bottle, and the proportioning assembly is arranged above the mixing bottle; the proportioning assembly comprises a rotating disc, a plurality of medicine dispensing bottles are arranged on the rotating disc, an upper opening and a lower opening are formed in the upper end and the lower end of each medicine dispensing bottle respectively, an isolation plate is arranged at the upper opening, a closed valve is arranged at the lower opening, and a medicine outlet is formed in the center of the closed valve; a pushing and pressing assembly is arranged above the upper opening; compared with the prior art, operation is easy, use is convenient, automatic proportioning can be achieved, safety is improved, and meanwhile proportioning accuracy is effectively improved.

Compounds having opioid characteristics are provided that can be used for various therapeutic methods including the treatment of pain and opioid use disorders, and compounds having opioid antagonist properties that can be used to treat opioid overdoses. These compounds include agonists and antagonists having selective activity toward more one or more opioid receptors. Such compounds can be full or partial agonists, or can be antagonists lacking agonist properties toward delta and kappa opioid receptors. The partial agonists can diminish side effects associated with traditional opioid medications, and the antagonists can overcome respiratory depression caused by potent narcotics. Structurally these compounds include constrained piperidines with alkenyl or cyanoalkyl groups, as well as other substituents providing desired properties.

The utility model discloses a drug detection dripping device which comprises a dripping device body, the dripping device body comprises a bottle body, a cover body, a dripping tube and a rubber cap, the cover body is rotatably installed at the top end of the bottle body, the dripping tube is arranged in the cover body, and the rubber cap is arranged at the top end of the dripping tube; by designing an elastic reset structure, after the protective cap and the elastic piece are arranged on the outer surface of the rubber cap in a sleeving mode and fixedly installed, the protective cap is pressed to extrude the rubber cap and the elastic piece, at the moment, the end of the dripping tube is immersed into the narcotics, the rubber cap is loosened, and suction is conducted; the rubber cap is driven to be quickly reset and sucked in the protective cap through deformation reset of the elastic piece, the suction operation is convenient, the situation that the rubber cap cannot be reset and the suction operation is influenced is avoided after long-time pressing use, and the convenience of the dripping device main body for resetting the rubber cap during drug detection suction operation is improved.

The utility model belongs to the field of medical medicine boxes, and particularly relates to an anesthetic box for an anesthetist. The device comprises a box body with a box cover on the top, a baffle used for dividing the interior of the box body into a front bin and a rear bin is vertically fixed in the box body, a plurality of partition plates capable of moving left and right are vertically arranged in each bin, and sliding grooves are horizontally formed in the front bin wall and the rear bin wall of each bin; sliding blocks sliding in the two sliding grooves in the corresponding bins are fixed to the front side wall and the rear side wall of each partition plate, taking-out grooves communicating with the corresponding sliding grooves and the top are vertically formed in the front bin wall and the rear bin wall of each bin, and a locking assembly is arranged between the baffle and each partition plate. According to medicines or tools needing to be stored, the positions of all the partition plates in the corresponding bins are moved, so that the size of the storage grids is adjusted to adapt to the size of the medicines or the auxiliary tools, the space utilization rate in the box body is increased under the condition that neat storage is not damaged, and more medicines or tools can be stored in each bin.

The invention provides a cyclic ketone compound prodrug and a medical effect thereof, and belongs to the technical field of anesthetic drugs. The cyclic ketone compound prodrug is a compound as shown in a formula I, a stereoisomer thereof, a deuterated derivative thereof, a salt thereof and a solvate thereof. It is found for the first time that the prodrug of the cyclic ketone compound has good general anesthesia and sedative antagonism effects, has good antagonism effects on general anesthesia induced by various general anesthesia drugs, and can also play an effective antagonism effect on general anesthesia continuously infused with the general anesthesia drugs. Meanwhile, the traditional Chinese medicine composition has a good improvement effect on respiratory depression caused by opioids and inhalation anesthetics. The invention provides a new choice for antagonists of anesthetic and / or sedative drugs, especially antagonists of general anesthetic drugs, and has wide application prospects. # imgabs0 #

The invention belongs to the technical field of anesthetic drugs, and particularly relates to an anesthetic drug and a preparation method thereof. The anesthetic is prepared by mixing 1000 parts by weight of bupivacaine liposome injection, 0.5-1 part by weight of magnesium sulfate and 3-5 parts by weight of dexmedetomidine hydrochloride. Wherein magnesium sulfate and dexmedetomidine hydrochloride are auxiliary agents, so that the anesthesia onset time is shortened. The anesthetic prepared by the invention is smaller in side effect, quick in effect taking and long in maintenance time, the injection frequency of the anesthetic can be reduced, the infection risk and the nursing cost can be reduced, the anesthetic effect is good, and the application prospect is wide.

1. Name of the designed product: anesthetic tray. 2. Use of the designed product: for placing anesthetics. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

A method for processing an anesthesia electroencephalogram signal is disclosed. The method includes acquiring an electroencephalogram signal by means of an electroencephalogram sensor; selecting a target anesthesia depth model from an anesthesia depth model database according to the type of a drug for anesthesia, each anesthesia depth model of the anesthesia depth model database being trained according to a specific drug type, a corresponding electroencephalogram signal, and a marked anesthesia depth; and obtaining an anesthesia depth value on the basis of the target anesthesia depth model and the electroencephalogram signal. In the processing method, according to the type of an anesthetic drug, an appropriate anesthesia depth model is selected, so that the depth of anesthesia can be obtained more accurately, and the adaptability to the type of the anesthetic drug is increased.

1. Name of the designed product: anesthetic tray. 2. Use of the designed product: the designed product is used as an anesthetic tray in surgery. 3. Design points of the designed product: in shape. 4. Picture or photo that best shows the design points: perspective view.

An example is directed to a method of preparing a pseudo narcotic propionic acid (PA). The method includes weighing out a microcrystalline cellulose (MCC); weighing out and transferring a synthetic silicon dioxide to a blender; adding a PA to the synthetic silicon dioxide in the blender; blending the PA and the synthetic silicon dioxide in the blender to form a first mixture; and adding the MCC to the first mixture in the blender and blending the MCC and the first mixture to form a second mixture as the pseudo narcotic PA.

The invention belongs to the technical field of local anesthesia, and particularly relates to an automatic drug delivery anesthesia patch which comprises a paper tearing layer, a pasting layer, an injection layer and a drug storage layer which are attached in sequence, and the injection layer comprises an injection bin, a microneedle and a driving mechanism; the medicine storage layer comprises a medicine storage bin and an anesthetic conveying mechanism, and the pasting layer, the injection bin and the medicine storage bin are sequentially attached to one another; anesthetic is stored in the medicine storage bin; the number of the microneedles is multiple, and the multiple microneedles are movably installed in the injection bin. The driving mechanism is mounted in the injection bin; the medicine storage bin is communicated with the injection bin through the anesthetic conveying mechanism; and the microneedle is provided with an injection channel communicated with the injection bin. The anesthesia patch can carry more anesthetic drugs, better anesthesia is achieved, the anesthesia time is longer, additional pressure does not need to be applied in the injection acupuncture process, the injection acupuncture process is rapid, process stabbing pain can be effectively reduced, and painless anesthesia is better achieved.

1. Name of the designed product: anesthetic tray. 2. Use of the designed product: anesthetic tray for use in surgery. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view.

A portable detection kit for identifying the presence of narcotic compounds (NCs) includes at least one chemical dye, a catalytic reagent, at least one solvent, and a least one surfactant. The at least one dry chemical dye is configured to undergo physic-chemical interaction with at least one predetermined NC to produce a color visible change. The at least one predetermined NC is selected from the group consisting of fentanyl analogues (FAs) and narcotics containing nitrogen heterocyclic moiety.

The invention provides a method and a device for detecting narcotics and metabolites thereof in hair based on Raman spectrum, and relates to the technical field of narcotics detection.According to the method, a hair sample is collected, a sample with a known narcotics concentration value is modulated, spectral data is collected through a Raman spectrometer, and a spectral data matrix and a response variable matrix are recorded; generating a relation matrix reflecting the relevance between the spectral data matrix and the response variable matrix, generating a confidence vector reflecting the direction relation between the response variable matrix Y and the spectral data matrix X to the maximum extent by analyzing the relevance between the weight vector and the spectral data matrix, generating a reflection matrix after reflection, and outputting a confidence index. And comparing the confidence index with a confidence threshold, and outputting whether the Raman spectrometer detection concentration is effective or not in the current environment.