38 results about "Anesthetic Effect" patented technology

Disclosed in the present invention are a benzodiazepine compound, a pharmaceutical composition and the use thereof. Specifically provided is a compound represented by formula I, or a stereoisomer thereof, a deuterated compound thereof, or a pharmaceutically acceptable salt thereof. The compound provided in the present invention has one or more of the following advantageous effects: (1) the compound of the present invention exhibits good intravenous sedative and anesthetic effects; (2) the compound of the present invention exhibits low drug accumulation and a good tolerance; and (3) the compound of the present invention achieves an anesthetic effect with faster recovery.

The invention discloses clinical ventilation equipment for general anesthesia in the orthopedics department, relates to the technical field of anesthesia respirators, and aims to solve the problems that the gas tightness is reduced and the anesthesia effect is weakened due to the fact that the respirators fall off when a patient sideways. Suction cups adsorbed to the face of a patient are arranged on the two sides of the respirator, and an adsorption force strengthening assembly used for strengthening the adsorption effect of the suction cups is arranged on the respirator. An adjusting sliding rod on one side slides through rotation of a swing rod, an adjusting sliding block is extruded to enable an adjusting cavity to be communicated with one adjusting gas path, meanwhile, an adjusting piston slides into the adjusting cavity, gas is extruded into a connecting pipe through the adjusting gas path, the piston is extruded and driven to slide, and a suction cup piston rod in a suction cup moves; the suction effect of the suction cup on the face of the patient is enhanced, the air tightness of the respirator is improved, and the situation that the respirator falls off or a gap is generated between the respirator and the face when the patient sideways, and then the anesthesia effect is affected is prevented.

The invention provides a heterocyclic compound and a pharmaceutical composition and application thereof, and belongs to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

Provided in the present invention are a heterocyclic compound and the use thereof, belonging to the technical field of pharmaceutical chemistry. A series of heterocyclic compounds prepared in the present invention have highly efficient sedative, hypnotic, and / or anesthetic effects, can control status epilepticus, and also have analgesic effects, thus providing a new option for the clinical preparation of a drug having analgesic effects, a drug having anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus, and a drug having anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus which also has analgesic effects.

The invention relates to an adjustable spraying device for clinical anesthesia in the anesthesiology department, and belongs to the technical field of medical instruments. In order to enable anesthetics to accurately and efficiently reach a target anesthesia area, the adjustable and controllable spraying device for clinical anesthesia in the anesthesiology department comprises a spraying pipe and an air curtain assembly, the spraying pipe comprises an inner pipe and an outer pipe, a plurality of spraying holes are formed in the tail end of the inner pipe, the inner pipe is sleeved with the outer pipe, and an air conveying cavity communicated with an air pump is formed between the outer pipe and the inner pipe; the air curtain assembly comprises an elastic cylinder arranged in the air conveying cavity, one end of the elastic cylinder is configured to move in the direction close to or away from the inner pipe so as to change the flowing direction and the flowing range of airflow in the air conveying cavity, and the other end of the elastic cylinder is slidably connected with the inner pipe. The air curtain assembly can control the anesthetic spraying direction and spraying range, the anesthetic can accurately and efficiently reach the target anesthesia area, the spraying range is controlled within the target anesthesia area, anesthetic waste is reduced, and the anesthesia effect and anesthesia safety are improved.

The present invention belongs to the technical field of medicine. Provided are a compound, and a preparation method therefor and the use thereof. The compound has a structure as shown in formula I. The compound of the present invention not only has efficient sedative, hypnotic and / or anesthetic effects, and the ability to control status epilepticus, but also exhibits an analgesic effect, and can reduce or avoid the use of opioid analgesics such as fentanyl, alfentanil, sufentanil or remifentanil in clinical application, thereby reducing the occurrence of adverse reactions such as circulatory depression, respiratory depression, urinary retention and pruritus caused by opioid analgesics.

The invention relates to the technical field of medicines, and particularly discloses compound lidocaine cream as well as a preparation method and application thereof. The invention provides compound lidocaine emulsifiable paste. The compound lidocaine emulsifiable paste is specifically prepared from the following components in parts by weight: 22 to 26 parts of lidocaine, 22 to 26 parts of prilocaine, 13 to 17 parts of solubilizer, 9 to 11 parts of carbomer, 3 to 5 parts of sodium hydroxide and 0.02 to 0.06 part of penetration enhancer, the total amount is 1000 parts. The solubilizer is formed by mixing polyoxyethylene hydrogenated castor oil and poloxamer 188 in a weight ratio of (10-15): (1-4); the penetration enhancer is prepared by mixing L-ethyl lactate and oleic acid in a weight ratio of (1-4): (0.2-1). The compound lidocaine emulsifiable paste prepared by the invention has good safety, and the compound lidocaine emulsifiable paste has the effects of quicker effect taking, deeper anesthetic effect and longer duration time.

The utility model discloses a novel anaesthetic mask for rats, which relates to the technical field of animal anaesthetic masks and comprises an air inlet pipe, one end of the air inlet pipe is fixedly connected with a fixing ring, the outside of the fixing ring is fixedly connected with a communicating pipe, one end of the communicating pipe is fixedly connected with a ventilating balloon, and the other end of the communicating pipe is fixedly connected with an air outlet pipe. A plurality of ventilation holes are formed in the outer surface of the ventilation balloon, and the ventilation balloon is arranged in the oral cavity of the rat. When a rat needs to be anesthetized, firstly, the head of the rat penetrates through the sleeve opening and enters the soft mask, then the ventilation ball is arranged in the oral cavity of the rat, the lower incisor of the rat is clamped in the clamping opening formed in the middle of the fixing ring, and the soft mask and the rat are fixed through the effect of the binding belt. Then anesthetic gas can be introduced through the air inlet pipe and directly enters the oral cavity of the rat through the air inlet pipe, the fixing ring, the communicating pipe, the ventilating ball and the ventilating hole, and the problem that the anesthetic effect is affected due to anesthetic gas leakage is solved.

The invention discloses a local anesthetic spraying device capable of improving operation stability for the anesthesiology department, and belongs to the field of medical instruments, a storage cylinder for containing anesthetic liquid is provided, a spraying assembly is arranged on the storage cylinder, and the spraying assembly is used for switching sprayers with different precisions to spray an affected part; the driving assembly is arranged in the storage cylinder, the driving assembly is used for stably extruding the anesthetic liquid medicine in the storage cylinder, and meanwhile, the spraying dosage can be set; the adding assembly is arranged on the storage cylinder; the spraying assembly adapts to different anesthesia scenes by switching sprayers with different precisions, liquid medicine spraying is more targeted, the driving assembly extrudes the liquid medicine through stable power output, force fluctuation of manual pressing is avoided, meanwhile, through the dose setting function, it is ensured that the amount of the liquid medicine sprayed every time is consistent, and the spraying efficiency is improved. Influence of anesthesia effect caused by insufficient dosage or adverse reaction caused by excessive dosage are avoided.

This invention provides an upper respiratory tract surface anesthesia device, belonging to the technical field of anesthesia devices. Its features include an inlet pipe, a connecting pipe, and a spray nozzle. The lower end of the inlet pipe is connected to the connecting pipe via a flexible tube for connecting to an external drug or air supply line. An adjusting rod is slidably fitted on the outer side of the inlet pipe. The upper end of the inlet pipe has a conical tube, and a movable sleeve rod is movably fitted on the outer side of the conical tube. The spray nozzle is located at the upper end of the conical tube for spraying anesthetic liquid. The upper end of the conical tube has a sealing sleeve, and the inner side of the sealing sleeve has a support rod. The upper end of the adjusting rod has an ear plate, and the inner side of the ear plate is rotatably connected to a connecting rod that is rotatably connected to the movable sleeve rod. This allows the adjusting rod to adjust the angle of the support rod to cooperate with the sealing sleeve in sealing the airway. The advantages of this invention are: effective sealing of the target airway, prevention of drug leakage, significantly improved drug utilization and anesthetic effect, and convenient operation.

The invention belongs to the technical field of medical instruments, and particularly relates to a drug delivery device and a method thereof.The drug delivery device comprises a central control board, an anesthesia pump unit is connected with the central control board and used for delivering anesthetic drugs according to an anesthesia plan preset by a doctor, and a physiological monitoring unit is connected with the central control board and used for monitoring the anesthetic drugs. The anesthesia pump unit is used for monitoring vital signs, heart rate, blood pressure, respiration, body temperature, oxygen saturation and electroencephalogram of a patient in real time to evaluate the anesthesia depth, generating first data information and transmitting the first data information to the central control board, the anesthesia pump unit is combined with the monitoring system, and the vital signs and brain waves of the patient are monitored in real time through multiple feedback mechanisms; according to the anesthesia depth and physiological parameters of a patient, the administration amount and the administration rate of the medicine are adjusted in real time, accurate control over the anesthesia effect is ensured, the anesthetic medicine is safely and efficiently released in the whole process, the anesthesia depth is prevented from being too large or too small, and the manual operation risk is reduced.

The present invention belongs to the technical field of medicine. Provided are a compound, and a preparation method therefor and the use thereof. The compound has a structure as shown in formula I. The compound of the present invention not only has efficient sedative, hypnotic and / or anesthetic effects, and can control status epilepticus, but also has an analgesic effect, and can reduce or avoid the use of opioid analgesics such as fentanyl, alfentanil, sufentanil or remifentanil in clinical application, thereby reducing the occurrence of adverse reactions such as circulatory inhibition, respiratory inhibition, urinary retention and pruritus caused by opioid analgesics.

The invention relates to a novel cyclic quaternary ammonium salt compound as well as a preparation method and application thereof. The invention provides a compound as shown in a formula (I), or a deuterated compound, a solvate or a pharmaceutically acceptable salt thereof. The cyclic quaternary ammonium salt compound has a long-acting anesthetic effect, and the compound and the composition thereof can prolong the anesthetic action time and relieve postoperative pain and chronic pain.

The invention belongs to the technical field of anesthetic drugs, and particularly relates to an anesthetic drug and a preparation method thereof. The anesthetic is prepared by mixing 1000 parts by weight of bupivacaine liposome injection, 0.5-1 part by weight of magnesium sulfate and 3-5 parts by weight of dexmedetomidine hydrochloride. Wherein magnesium sulfate and dexmedetomidine hydrochloride are auxiliary agents, so that the anesthesia onset time is shortened. The anesthetic prepared by the invention is smaller in side effect, quick in effect taking and long in maintenance time, the injection frequency of the anesthetic can be reduced, the infection risk and the nursing cost can be reduced, the anesthetic effect is good, and the application prospect is wide.

A piperazine substituted phenol derivative and its applications in pharmaceutical chemistry are provided. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum effective anesthetic dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and / or anesthetic effects, as well as in drugs for controlling status epilepticus.

The invention belongs to the technical field of anesthesia dressings, and discloses a pharmaceutical composition for local anesthesia and a preparation method thereof. The pharmaceutical composition for local anesthesia is prepared from the following components: 10 to 20 parts of procaine, 0.9 to 1.5 parts of bergenin, 3 to 5 parts of a stabilizer, 5 to 10 parts of a surfactant, 1 to 3 parts of sodium carboxymethyl cellulose and 70 to 80 parts of normal saline. When the pharmaceutical composition for local anesthesia is applied to the skin, the anesthetic effect of the drug procaine can be remarkably enhanced, the local anesthesia duration can be prolonged, the clinical administration frequency can be reduced, and the stability of the drug procaine can be improved. The pharmaceutical composition for local anesthesia is safe and non-irritant to skin, and has a good application prospect.

The application discloses a kind of based on pattern recognition's anesthetic depth monitoring and drug infusion speed adjusting method and system, method includes: obtaining multidimensional standard physiological data;According to preset rate, increase infusion rate, draw first curve and determine anesthetic effect lag length;When anesthetic score reaches first preset score, according to preset rate, gradually decrease infusion rate, real-time acquisition second multidimensional standard physiological data, draw second curve;Obtain the intersection of two curves and record it as anesthetic steady-state equilibrium point and determine steady-state infusion rate;Infusion rate is adjusted to steady-state infusion rate.The application avoids the anesthesia process in traditional anesthesia process, anesthesia process is extremely dependent on clinical experience, for the influence problem of different individual, different age and other factors of patient, through the first curve and second curve of patient's own, directly determine corresponding steady-state infusion rate, increase the stability of anesthesia process.

Provided are an anesthetic effect prediction system and a program that provide information that can be easily utilized even by an anesthesiologist with poor knowledge and experience.　An anesthetic effect prediction system 1 comprises: an information acquisition unit 11 that acquires a measurement value of biological information of a target patient to whom an anesthetic has been administered; and an arithmetic processing unit 12 that predicts, on the basis of the measurement value, future variation of the biological information in the target patient.

The invention discloses an anesthetic atomizing device for surgical anesthesia, which relates to the technical field of medical instruments and comprises a main body assembly for realizing oxygen delivery and linkage installation of each component, an atomizing liquid supply assembly for storing and atomizing anesthetic liquid and a mist outlet control assembly for controlling the on-off of an atomized mist outlet channel, the valve element is used for receiving the thrust of the oxygen airflow and serves as a linkage triggering piece to drive the atomization liquid supply assembly to be started and drive the mist outlet control assembly to be opened. Automatic synchronous triggering of the three parts is achieved through structural linkage, sequential operation of medical staff is not needed, the problem of time sequence deviation caused by manual operation is avoided, the conditions of anesthesia induction delay, slow effect and the like caused by atomization starting lag are avoided, and the operation efficiency is improved. The problems of anesthetic leakage and waste, unstable fog drop concentration and the like caused by premature opening of the fog outlet are also prevented, the anesthetic effect is guaranteed, meanwhile, the drug loss is reduced, the anesthetic process can be quickly started in an emergency operation scene, and the situation that the anesthetic opportunity is delayed due to tedious operation steps is avoided.

The multifunctional skin freezing anesthesia equipment comprises a frame assembly, a cold air generation mechanism and a smoke suction mechanism, the frame assembly comprises an outer frame, a lower supporting plate and a middle supporting plate, the lower supporting plate is arranged at the bottom of the outer frame, the middle supporting plate is arranged in the middle of the outer frame, and the cold air generation mechanism is arranged on the inner side of the outer frame; a smoke suction mechanism is arranged on the upper side of the middle supporting plate. The cooling system assembly connection and airflow guiding design is unreasonable, the refrigerant circulation efficiency is low, meanwhile, airflow is not evenly distributed in equipment, and the refrigeration and anesthesia effects are further reduced.

Disclosed in the present invention are a substituted nitrogen heterocyclic compound and anesthetic action thereof. Specifically provided a chemical compound as shown in formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, a prodrug thereof, a metabolite thereof or a deuterated derivative thereof. The substituted nitrogen heterocyclic compound provided in the present application has good central nervous system inhibition effects, capable of generating sedative, hypnotic and / or general anesthetic effects, and capable of controlling status epilepticus; said substituted nitrogen heterocyclic compound is also characterized by rapid onset of action and rapid recovery, while maintaining positive anesthetic activity; in addition, said substituted nitrogen heterocyclic compound has almost no inhibitory effect on adrenocortical function, low side effects, and resolves technical difficulties in the art. The present invention provides a new selection for clinical screening and / or preparation of sedative, hypnotic and / or general anesthetic drugs and drugs controlling status epilepticus.

The invention relates to a novel pyrimidine derivative and application thereof. Specifically, the invention relates to a compound as shown in a formula I, a preparation method of the compound, a pharmaceutical composition and a combined product containing the compound, and application of the compound, the pharmaceutical composition or the combined product in preparation of central inhibitory drugs with sedative hypnotic and / or anesthetic effects,

The utility model relates to the technical field of medical instruments, in particular to an inferior alveolar nerve anesthesia indicator. The two sides of the connecting rod are connected with indicating rods. The two indicating rods are symmetrically arranged on the two sides of the base station respectively; an indicator connecting seat is fixed on the base station. When the odontoscope is used, the indicator connecting seat is fixedly connected with the odontoscope handle; the two indicating rods are respectively positioned at the highest point of a condyle process and the lowest point of a mandibular angle incisura, so that the indicator connecting seat is directly aligned and positioned with a mandibular small tongue, and the anesthesia effect is guaranteed.

The invention belongs to the technical field of respirators and discloses a precise quantitative inhalation type anesthesia respirator which comprises a respirator body, an air inlet pipe and an expiration pipe are connected to the outer side of the respirator body, a secondary mixer is fixedly connected to the other end of the air inlet pipe, and the expiration pipe and the secondary mixer both communicate with a sealing mask. A rotating part is elastically and rotatably mounted on the inner side of the secondary mixer, a movable plate is hermetically and slidably mounted on the inner side of the secondary mixer, a through hole is formed in the center of the movable plate, a one-way valve plate is hermetically, elastically and telescopically mounted at the position of the through hole in the movable plate, and an elastic rubber part is fixedly connected between the rotating part and the movable plate. The precise quantitative inhalation type anesthetic respirator can perform secondary mixing on medicaments before inhalation, improves the uniformity of inhaled gas, and can automatically clean residual anesthetic medicaments in the pipeline, so that the residual medicaments are prevented from influencing the subsequent inhalation volume precision, precise quantitative inhalation is realized, and the anesthetic effect is improved.

The invention discloses a benzodinitrogen compound, a pharmaceutical composition and application of the benzodinitrogen compound. Specifically provided are a compound represented by formula I, and a stereoisomer, a deuterated compound or a pharmaceutically acceptable salt thereof. The compound provided by the invention has one or more advantages and effects as follows: (1) the compound provided by the invention has a relatively good vein sedation and anesthesia effect; (2) the compound provided by the invention is small in drug accumulation effect and good in tolerance; and (3) the compound disclosed by the invention has an anesthetic effect of more quickly reviving.

Device (1) for determining a combined anesthetic effect on a patient anesthetized by means of a combination of at least two active substances characterized in that the device is set up to perform the following steps: Determining the concentration of each active ingredient at the site of action using pharmacokinetic and / or pharmacodynamic models; Summarizing the effect of all active ingredients within each class of active ingredients used, whereby the potency of the active ingredients is added if they act on the same receptor type; Determining the synergistic interaction between at least two active substances used in anesthesia by determining a combined potency N of the anesthetic effect of the applied active substances, based on a mean anesthetic efficacy of the active substances used and an interaction term. determining an NSRI index value NSRI = 100 ∗ ( 1 − ( N / N ' ) sl 1 + ( N / N ' ) sl ) , where - N is the combined power, - N' is a specific value at which an NSRI value of 50% is reached. - and sl is a slope factor for a transformation from N to NSRI; Display of the NSRI index value using a display device (29); and Display of at least one comparative value (67, 69) for anesthesia management and / or patient arousal by means of the display device (29).

The invention belongs to the technical field of medicine synthesis and application, and particularly relates to an etomidate derivative and a preparation method and application thereof. Compared with etomidate, the compounds as shown in the formulas I and II or the isomers thereof provided by the invention partially have better anesthetic effect and more excellent effective dose, and are drugs capable of being used in the aspect of anesthesia.

The application discloses a method and system for analyzing anesthetic depth, which first sets a standard anesthetic depth analysis model, then acquires original physiological parameters, carries out abnormal value screening pretreatment, acquires an actual physiological parameter set, carries out correction calculation on the actual physiological parameter set, acquires a basic parameter set, finally outputs a current anesthetic state parameter according to the basic parameter set and the standard anesthetic depth analysis model, and simultaneously outputs a predicted anesthetic state parameter according to a plurality of basic parameter sets and the standard anesthetic depth analysis model. The application realizes automatic data acquisition and calculation, effectively reduces the workload of an anesthetist, and is favorable for improving anesthetic effect. Meanwhile, the application effectively reduces the dependence on personal experience through data quantitative analysis, improves the objectivity and accuracy of analysis results, and can also predict the change trend of anesthetic depth according to existing data, so that early intervention is facilitated, and the comprehensiveness of anesthetic depth monitoring is improved.

A dental anesthetic buffering system using pre-dosed dry buffering material. Liquid dental anesthetic from a standard anesthetic cartridge or carpule is injected into a dry buffering material buffering the anesthetic improving efficacy and comfort. A buffer dosing cartridge or carpule configured to fit within an anesthetic syringe is pre-dosed with a dry buffering material and injected with a liquid anesthetic from a standard anesthetic cartridge or carpule forming a buffered anesthetic cartridge or carpule. The buffered anesthetic cartridge or carpule is placed in an anesthetic syringe used to immediately administer the buffered anesthetic to a patient. Ease-of-use, effectiveness, and comfort to the patient are provided making dentistry easier.