117 results about "Anesthetic Effect" patented technology

The invention relates to the technical field of anesthesia effect evaluation, in particular to an anesthesia effect evaluation system based on big data, which comprises a physiological data processing module, a patient grouping and analysis module, an anesthesia risk evaluation module and an anesthesia adjustment support module. And collecting physiological indexes and types and doses of anesthetic drugs. According to the method, the real-time processing capacity of physiological data is enhanced by integrating historical health records and operation information, accurate evaluation of the instant effect of anesthetic is provided by deeply analyzing time sequence changes of heart rate and blood pressure, the response of different patient groups to the anesthetic can be recognized through grouping analysis, and the accuracy of the anesthetic is improved. Therefore, a targeted anesthesia scheme is realized, the anesthetic injection time and dosage are analyzed by using the LSTM network, the dynamic prediction of drug response is optimized, a doctor is supported to adjust the anesthetic dosage according to real-time data, the precision and safety of anesthesia management are greatly improved, and the anesthesia side effect risk is reduced.

The invention belongs to the technical field of medical and mechanical combinations, and discloses a high-permeability and low-sensitivity ripdicaine wound patch and a preparation method thereof.The high-permeability and low-sensitivity ripdicaine wound patch comprises a wound patch body, and the wound patch body is prepared from, by mass, 0.1%-0.4% of sodium hyaluronate, 1.5%-3.5% of lidocaine, 1.5%-3.5% of prilocaine, 3%-10% of solvent, 0.5%-8% of emulsifier, 2%-10% of humectant, 0.1%-5% of soothing agent, 0.1%-1.5% of stabilizer, 0.1%-1% of thickener and the balance water. According to the present invention, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, and the total amount of the raw materials is 100%. And the anesthetic has the advantages of quick effect taking, low sensitivity, capability of resisting moist heat sterilization and good stability.

The present invention relates to the technical field of pharmaceutical chemistry, and provides a heterocyclic compound and a pharmaceutical use thereof. The structure of the heterocyclic compound is as shown in formula II. The compound of the present invention has high-efficiency sedative, hypnotic and / or anesthetic effects, can control status epilepticus, and also has an analgesic effect, providing a new choice for clinical preparation of a drug having the analgesic effect, a drug having the anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus, and a drug having both the anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus and also having the analgesic effect.

The invention discloses an anesthesia effect prediction method based on a graph neural network. The method comprises the following steps: obtaining a standardized synchronization time sequence data set; forming a time sliding window sequence; generating an initial topology of the dynamic physiological index-drug effect variable diagram structure; generating a node initial feature representation set for each graph node, and initializing a graph neural network model parameter set; obtaining an updated dynamic physiological index-drug effect variable diagram structure; inputting the pharmacodynamic variable graph structure into a graph neural network model corresponding to the graph neural network model parameter set to obtain a node embedding representation set and an edge embedding representation set; outputting an induction period anesthesia effect prediction result set; and generating an interpretable output result set, wherein the interpretable output result set comprises a key variable link, a dominant influence factor and a drug administration adjustment suggestion. The rapid detection capability of the abnormal state in the induction period is improved.

The invention provides a surface anesthesia application and a preparation method thereof, and belongs to the technical field of application. The surface anesthesia application is composed of a base material and anesthetic liquid, and the anesthetic liquid is prepared from, by mass, 0.5-10% of anesthetic, 0-1% of sodium hyaluronate, 0.1-10% of penetration enhancer, 0.1-1% of thickening agent, 0.01-0.5% of pH value regulator, 0.1-1% of preservative, 0-5% of emulsifier and the balance water. The surface anesthesia application prepared by the invention takes effect quickly, has a good anesthesia effect, reduces the dosage of anesthetics, and is convenient to use and low in cost.

A substituted phenol derivative and the use thereof, which relates to the field of medicinal chemistry. The substituted phenol derivative is a compound represented by formula I, or a stereoisomer, a pharmaceutically acceptable salt, a solvate, a prodrug, a metabolite, or a deuterated derivative thereof. The derivative not only has sedative, hypnotic and / or anesthetic effects, but also has an analgesic effect. The derivative can control status epilepticus, and has good safety during use. Therefore, the derivative has broad application prospects in the preparation of a drug having both sedative, hypnotic and / or anesthetic effects and an analgesic effect and capable of controlling status epilepticus, and provides a new option for the clinical preparation of a drug having both an analgesic effect and sedative, hypnotic and / or anesthetic effects, which is capable of controlling status epilepticus, etc.

The present invention provides an intelligent method and system for target control of adult anesthesia based on EEG signal monitoring, and the method includes: determining the anesthesia scheme for the target adult based on the type of surgery of the target adult, and determining the target anesthetic agent required for the anesthesia of the target adult based on the anesthesia scheme; injecting the target anesthetic agent into the target adult based on a preset injection pump, and collecting the EEG signal of the target adult in real time; determining the sedation depth and analgesia depth of the target adult based on the EEG signal, and controlling the injection speed of the preset injection pump and the injection amount of the target anesthetic agent based on the sedation depth and analgesia depth, so as to complete the intelligent target control of adult anesthesia. By collecting the EEG signal of the target adult in real time, it is convenient to understand the current sedation depth and analgesia depth of the target adult according to the EEG in real time, thereby improving the accuracy of adjusting the injection pump and the anesthetic agent, improving the anesthesia effect, and reducing the damage caused by anesthesia.

Disclosed in the present invention are a benzodiazepine compound, a pharmaceutical composition and the use thereof. Specifically provided is a compound represented by formula I, or a stereoisomer thereof, a deuterated compound thereof, or a pharmaceutically acceptable salt thereof. The compound provided in the present invention has one or more of the following advantageous effects: (1) the compound of the present invention exhibits good intravenous sedative and anesthetic effects; (2) the compound of the present invention exhibits low drug accumulation and a good tolerance; and (3) the compound of the present invention achieves an anesthetic effect with faster recovery.

The present invention relates to the technical field of pharmaceutical chemistry, and provides a heterocyclic compound and a use thereof. The structure of the heterocyclic compound is as shown in formula II. The compound of the present invention has efficient sedative, hypnotic and / or anesthetic effects, can control the status epilepticus, further has an analgesic effect, and provides a new option for clinically preparing a drug having an analgesic effect, a drug having anesthetic, sedative and hypnotic effects and / or capable of controlling the status epilepticus, and a drug having anesthetic, sedative and hypnotic effects and / or capable of controlling the status epilepticus and also having the analgesic effect.

The invention provides a heterocyclic compound and a pharmaceutical composition and application thereof, and belongs to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

The invention discloses a substituted phenol compound as well as a preparation method and application thereof. According to the present invention, the propofol is subjected to structure optimization to obtain the compound having the structure represented by the formula (I), such that the safety is significantly improved, the anesthetic effect is excellent, various preparation forms can be conveniently prepared, the clinical application in various drug delivery forms can be easily achieved, the structure is novel, and the preparation method is simple. # imgabs0 #

The present invention relates to the technical field of medical devices, and specifically to a medical anesthesia machine capable of preventing anesthetic reflux. The present invention comprises: a main body mechanism, a drug filling mechanism and a mask mechanism. The main body mechanism comprises a columnar shell and a support frame. An anti-skid column is fixedly installed on the top of the columnar shell, an anesthetic treatment medicine tube is installed on the anti-skid column, an anesthetic treatment medicine tube is fixedly connected to the inner wall of the anesthetic treatment medicine tube with an anesthetic evaporator, and a sealing plug is slidably embedded between the anesthetic treatment medicine tube and the anesthetic evaporator. During the atomization anesthesia process, the present invention can coordinate the operation of various components of the device through an automated control system according to the patient's inhalation and exhalation states, push the atomized anesthetic gas to be delivered to the mask for the patient to inhale during inhalation, stop the delivery in time and close the corresponding passage during exhalation, so that the anesthetic delivery is synchronized with the patient's breathing, which not only ensures the anesthesia effect but also greatly reduces the possibility of anesthetic reflux caused by reverse pressure difference.

The present invention relates to a soluble microneedle for local anesthesia and a local anesthesia patch comprising same, the soluble microneedle comprising an amide-based local anesthetic, hyaluronic acid, and polyvinylpyrrolidone in a specific content ratio. The present invention uses the soluble microneedle to implement direct drug delivery by physically permeating through the stratum corneum and mucosa, and thus a precise and rapid anesthetic effect may be exhibited. Especially, the microneedle comprising a specific amount of polyvinylpyrrolidone is dissolved, and the anesthetic contained in the microneedle is rapidly delivered to nerve cells, and thus the disadvantage of a long waiting time of conventional anesthetic creams may be overcome, and thus the present invention has the advantage of being usable in various ways in dental, dermatology, and other surgical procedures requiring local anesthesia.

The invention discloses a dexmedetomidine and propofol combined reagent and a combination method, and relates to the technical field of combined use of anesthetic drugs. According to the method, firstly, dexmedetomidine is subjected to intravenous pump injection within 5-15 minutes according to the dosage of 0.5-1.0 mu g / kg, propofol is given within 2 minutes after the dexmedetomidine is subjected to general anesthesia, and the dosage of the propofol can be reduced by 10%-50% compared with that of propofol which is independently used. Through pretreatment of dexmedetomidine, the anesthetic effect of propofol can be enhanced, adverse reactions such as blood pressure drop and respiratory depression can be effectively reduced, and anesthetic safety and controllability are improved. The combined reagent comprises independent containers for respectively loading the dexmedetomidine injection and the propofol emulsion, and can be packaged by adopting a double-cavity pre-filled injector, and sequential injection is realized through a controllable opening mechanism, so that unstable emulsification and titer change caused by physical mixing of medicines are avoided.

The invention discloses substituted phenol derivatives and application thereof, and relates to the field of medicinal chemistry. The substituted phenol derivative is a compound as shown in a formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof, or a deuterated derivative thereof. The derivative not only has sedative, hypnotic and / or anesthetic effects, but also has an analgesic effect, can control the state of epilepsy, and is good in safety during use. Therefore, the derivative has wide application prospects in preparation of drugs which have sedative, hypnotic and / or anesthetic effects and analgesic effects and can control the epileptic status. The invention provides a new choice for clinically preparing medicines which have the effects of easing pain, calming, hypnotizing and / or anesthetizing, controlling the epileptic status and the like. # imgabs0 #

Spinal cord modulation for inducing paresthetic and anesthetic effects, and associated systems and methods are disclosed. A representative method in accordance with an embodiment of the disclosure includes creating a therapeutic effect and a sensation in a patient by delivering to the patient first pulses having a first set of first signal delivery parameters and second pulses having a second set of second signal delivery parameters, wherein a first value of at least one first parameter of the first set is different than a second value of a corresponding second parameter of the second set, and wherein the first pulses, the second pulses or both the first and second pulses are delivered to the patient's spinal cord.

The utility model belongs to the technical field of medical instruments, and particularly relates to an anaesthetic mask which is mainly used for anesthetizing a patient with a stomach tube. The mask mainly comprises a mask body; the flexible pad forms a closed pattern along the edge of the mask body, and a groove is formed in the flexible pad in the direction towards the mask body; the sealing piece is arranged in the groove, and the sealing piece is arranged along the edge of the groove; mainly solves the problems that when a stomach tube is reserved on a patient, the periphery of an anaesthetic mask cannot be completely attached to the face of the patient due to the existence of the stomach tube, so that a gap exists between the anaesthetic mask and the face of the patient, and the anaesthetic effect is greatly reduced due to air leakage in the ventilation process.

The invention discloses a portable anesthetic gas mixing device, and belongs to the technical field of medical instruments. The anesthetic gas mixing device comprises a box body, an oxygen bottle, an anesthetic gas bottle and a converging pipe, wherein the oxygen bottle and the anesthetic gas bottle are arranged in the box body; the converging pipe is communicated with the oxygen bottle and the anesthetic gas bottle and penetrates through the box body; the gas conveying pipe is connected with the oxygen bottle and the anesthetic gas bottle far away from the afflux pipe; and the oxygen mask is fixedly connected with one end, far away from the afflux pipe, of the gas conveying pipe. According to the portable anesthetic gas mixing device, the flow of oxygen and anesthetic gas can be controlled by arranging the regulator, so that the oxygen and the anesthetic gas can be preliminarily mixed in the balloon and then further mixed through the mixer, and the gas mixing efficiency and effect are improved; meanwhile, the piston assembly can be synchronously used for inflating the air bag, so that the oxygen mask is tightly attached to the face of the patient, discharge and waste of anesthetic gas are reduced, and the anesthetic effect is ensured.

The application discloses a monitoring and regulation system and method for an anesthesia maintenance period, and the system comprises: a database for storing vital sign data and drug injection data of the whole process of the anesthesia maintenance period; and an anesthesia auxiliary platform configured with a monitoring and regulation model, which is used for intelligent regulation of an anesthesia cycle in the anesthesia maintenance period and provision of an anesthesia maintenance strategy. The application performs real-time monitoring on basic life functions of a human body in the anesthesia maintenance period, combines an anesthesia drug artificial intelligence intelligent regulation model, intelligently evaluates anesthesia risks, and intelligently regulates the dosage of anesthesia drugs, which is beneficial to control of anesthesia quality, can achieve optimal anesthesia effect by using the least anesthesia drugs, and shortens the postoperative recovery time.

The present invention belongs to the technical field of biomedicine, and particularly relates to an anesthetic preparation containing trimecaine and a preparation method thereof. The anesthetic preparation containing trimecaine comprises the following raw materials in parts by weight: 8-12 parts of trimecaine, 0.5-1 part of lindenenolide, 0.3-0.8 part of sodium phytate, 1-5 parts of schizophyllan oligosaccharide, 3-5 parts of 1,2-propanediol, 2-6 parts of sodium carboxymethylcellulose, 3-8 parts of Tween, and 60-70 parts of physiological saline. The combination of lindenenolide and trimecaine added in the anesthetic preparation of the present invention can improve the anesthetic effect and prolong the anesthetic time. Sodium phytate and schizophyllan oligosaccharide in the anesthetic preparation act synergistically to effectively improve the stability of the anesthetic preparation. Among them, due to the film-forming property of schizophyllan oligosaccharide, it can also improve the anesthetic efficacy of the anesthetic preparation to a certain extent. In addition, the anesthetic prepared by the present invention has no obvious irritation to the skin.

The invention discloses clinical ventilation equipment for general anesthesia in the orthopedics department, relates to the technical field of anesthesia respirators, and aims to solve the problems that the gas tightness is reduced and the anesthesia effect is weakened due to the fact that the respirators fall off when a patient sideways. Suction cups adsorbed to the face of a patient are arranged on the two sides of the respirator, and an adsorption force strengthening assembly used for strengthening the adsorption effect of the suction cups is arranged on the respirator. An adjusting sliding rod on one side slides through rotation of a swing rod, an adjusting sliding block is extruded to enable an adjusting cavity to be communicated with one adjusting gas path, meanwhile, an adjusting piston slides into the adjusting cavity, gas is extruded into a connecting pipe through the adjusting gas path, the piston is extruded and driven to slide, and a suction cup piston rod in a suction cup moves; the suction effect of the suction cup on the face of the patient is enhanced, the air tightness of the respirator is improved, and the situation that the respirator falls off or a gap is generated between the respirator and the face when the patient sideways, and then the anesthesia effect is affected is prevented.

The invention relates to the technical field of medical apparatuses and instruments, and particularly discloses an anesthesia monitoring control device which comprises a fixing pad; the first traction wheel is arranged above the fixed pad; the second traction wheel is arranged above the fixed pad; when the anesthesia effect of a patient is weakened, the direct response shows that fingers curl up towards the palm center, a first traction rope pulls a second traction rope, a detection wheel rotates in a fixed shell, a locking block is retracted into a locking groove, meanwhile, under driving of a second connecting rod, the locking rod drives a baffle to rotate in the fixed shell, and the baffle presses a pressure sensor; the anesthetic is added to the patient, so that the patient can be in a deep anesthesia state in the orthopedic surgery, meanwhile, the situation that the traction assembly is misjudged due to the fact that the arm is shaken due to the fact that the surgical action is too large during the surgery of medical staff is prevented, and the traction detection assembly can rapidly detect the dynamic state of the patient, respond in time and reduce the hysteresis quality; anesthetics are added in time, and operation discomfort of a patient is reduced.

The invention belongs to the technical field of medical equipment, and particularly relates to an anesthetic needle inserting device for the anesthesiology department, the anesthetic needle inserting device comprises a control assembly, the control assembly is sequentially provided with a pushing assembly, a limiting assembly and a clamping assembly, the pushing assembly comprises a pushing frame, the pushing frame is provided with a sliding groove, one side of the pushing frame is fixedly connected with a clamping plate, and the clamping plate is fixedly connected with the limiting assembly. The clamping assembly comprises a clamping block, one side of the clamping block is fixedly connected with a sliding rod, one end of the sliding rod is fixedly connected with a limiting rod, an injector is clamped in the clamping block, the position of the limiting plate is accurately adjusted, the needle inserting length of the injector can be controlled, an anesthesia point can be conveniently and more accurately positioned in the anesthesia process, and the anesthesia accuracy is improved. The anesthesia effect is improved, and the problem that the anesthesia effect is poor due to the fact that the needle inserting depths are inconsistent is solved.

The invention discloses a perioperative period body temperature management method and system, and relates to the technical field of medical health data processing, and the system comprises a decision unit, a calculation unit, a communication unit, a body temperature acquisition unit, a manual input unit, a temperature control heating unit and the like. Based on multivariate data, a mathematical model which is efficient and high in response speed is established, intelligent decision-making adjustment of the body temperature is achieved, and the burden of medical staff in an operation is reduced; the risk of postoperative complications is reduced, the anesthesia effect and the recovery quality are improved, postoperative shivering and delayed waking are reduced, and the comfort and the satisfaction degree of a patient are improved; through effective body temperature and health information management, postoperative rehabilitation of a patient can be promoted, so that the hospitalization time is shortened, and medical resources are saved; and through an intelligent and individualized body temperature prediction and intervention technology, higher-quality perioperative period management is realized, and the development of precise medical treatment is promoted.

To provide an anesthesia effect prediction system and program that provide information that can be easily utilized even by an anesthesiologist with little knowledge or experience. [Solution] The anesthetic effect prediction system 1 includes an information acquisition unit 11 that acquires measurements of the biometric information of a target patient who has been administered an anesthetic, and an arithmetic processing unit 12 that predicts future changes in the biometric information of the target patient based on the measurements.

The invention relates to the technical field of nerve block anesthesia, and discloses nerve block anesthesia intelligent auxiliary equipment which comprises a display screen, the rear wall of the display screen is rotationally connected to the top of a second supporting column through a first supporting column, and the bottom of the second supporting column is fixedly connected to the top of a bottom plate. The outer wall of the second supporting column is fixedly connected to one end of a mechanical arm, the other end of the mechanical arm is fixedly connected to one end of a rotating shaft, the other end of the rotating shaft is fixedly connected with an ultrasonic detector, and a mechanical arm control system and an intelligent control unit are arranged in the display screen. An ultrasonic image recognition system is arranged in the ultrasonic detector, and the ultrasonic image recognition system scans a target area. In the invention, the ultrasonic detector can be pressed on the surface of the body of a patient through the mechanical arm, so that the problem of poor anesthesia effect possibly caused by the fact that a doctor needs to hold ultrasonic equipment with one hand and hold a needle with the other hand for anesthesia operation in nerve block anesthesia is solved.

The utility model relates to the technical field of inhalation masks for the anesthesiology department, and discloses a conveniently fixed inhalation mask for the anesthesiology department, which comprises a mask body, a left ear hanging belt and a right ear hanging belt, both sides of the mask body are provided with air outlets, the outlets of the air outlets are provided with filter covers, the inside of the mask body is connected with an air inlet pipe in a penetrating manner, and the left ear hanging belt is connected with the right ear hanging belt. An air inlet pipe is arranged in the mask body, a protective net is arranged in the air inlet pipe, a mounting seat is fixedly connected to the inner side face of the mask body, a nasal cavity protective cover is arranged on the mounting seat, the left ear hanging belt and the right ear hanging belt are fixedly connected with the mask body, a second fastening belt is fixedly connected to the left ear hanging belt, and a first fastening belt is fixedly connected to the right ear hanging belt. The first fastening belt is connected with the hook-and-loop fastener through the hook-and-loop fastener, the mask body can be better fixed to the face of the patient, meanwhile, the mask body is convenient to disassemble, anesthetic can be better inhaled through the nasal cavity of the patient, the anesthetic is not prone to loss, and the anesthetic effect is improved.

Abstract: A piperazine-substituted phenol derivative having the structure represented by formula (I) is provided. This compound not only has good salt-forming properties and excellent water solubility to meet pharmaceutical requirements, but also has a low minimum effective dose of anesthetics, rapid onset of action, and rapid recovery. This overcomes the drawbacks of prodrugs and lipid emulsion formulations of propofol and ciprofol, and is expected to be used in the preparation of drugs with sedative, hypnotic, and / or anesthetic effects and drugs for controlling status epilepticus. TIFF2025535407000076.tif41170

The utility model belongs to the technical field of animal anesthesia equipment, and particularly relates to an animal anesthesia induction box and an anesthesia system. The utility model discloses an animal anesthesia induction box, which is characterized in that a plurality of drawer boxes for placing animals are arranged in the induction box, target animals are convenient to find, the dissipation of anesthetic gas in the finding process is reduced, and independent activity spaces are separated by partition plates arranged in the drawer boxes, so that the animals are prevented from being irregularly stacked in the box. The utility model further discloses an anesthesia system which comprises the induction box, a detection device, a gas transmission device and a waste gas treatment device, the system can ensure that the concentration of anesthetic gas in the induction box is always in a stable threshold range, the anesthesia effect is improved, and environmental pollution is reduced.

The utility model relates to the field of spraying devices, and discloses an anesthetic spraying device which comprises a spraying box, the left side of the top of the spraying box is slidably connected with a drawing rod, the bottom of the drawing rod is fixedly connected with a piston, and the top of the inner wall of the spraying box is fixedly connected with a metering box. A one-way valve is fixedly connected to the bottom of the inner wall of the metering box, a spraying pipe is fixedly connected to the outer wall of the left side of the spraying box and penetrates through the inner wall of the left side of the metering box, a spraying head is slidably connected to the right side of the spraying pipe, buckles are fixedly connected to the four sides of the left end of the spraying head, and springs are fixedly connected to the inner walls of the left ends of the buckles; the upper side and the lower side of the spring are fixedly connected with clamping blocks, and the clamping blocks are in sliding connection with the inner wall of the buckle. According to the utility model, the dosage of anesthetic can be accurately controlled, so that the anesthetic effect is good, the discomfort of a patient to the anesthetic effect is reduced, and the spray head is conveniently replaced to face different scenes.