59 results about "Anesthetic Effect" patented technology

The invention belongs to the technical field of medical and mechanical combinations, and discloses a high-permeability and low-sensitivity ripdicaine wound patch and a preparation method thereof.The high-permeability and low-sensitivity ripdicaine wound patch comprises a wound patch body, and the wound patch body is prepared from, by mass, 0.1%-0.4% of sodium hyaluronate, 1.5%-3.5% of lidocaine, 1.5%-3.5% of prilocaine, 3%-10% of solvent, 0.5%-8% of emulsifier, 2%-10% of humectant, 0.1%-5% of soothing agent, 0.1%-1.5% of stabilizer, 0.1%-1% of thickener and the balance water. According to the present invention, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, and the total amount of the raw materials is 100%. And the anesthetic has the advantages of quick effect taking, low sensitivity, capability of resisting moist heat sterilization and good stability.

The invention discloses an anesthesia effect prediction method based on a graph neural network. The method comprises the following steps: obtaining a standardized synchronization time sequence data set; forming a time sliding window sequence; generating an initial topology of the dynamic physiological index-drug effect variable diagram structure; generating a node initial feature representation set for each graph node, and initializing a graph neural network model parameter set; obtaining an updated dynamic physiological index-drug effect variable diagram structure; inputting the pharmacodynamic variable graph structure into a graph neural network model corresponding to the graph neural network model parameter set to obtain a node embedding representation set and an edge embedding representation set; outputting an induction period anesthesia effect prediction result set; and generating an interpretable output result set, wherein the interpretable output result set comprises a key variable link, a dominant influence factor and a drug administration adjustment suggestion. The rapid detection capability of the abnormal state in the induction period is improved.

Disclosed in the present invention are a benzodiazepine compound, a pharmaceutical composition and the use thereof. Specifically provided is a compound represented by formula I, or a stereoisomer thereof, a deuterated compound thereof, or a pharmaceutically acceptable salt thereof. The compound provided in the present invention has one or more of the following advantageous effects: (1) the compound of the present invention exhibits good intravenous sedative and anesthetic effects; (2) the compound of the present invention exhibits low drug accumulation and a good tolerance; and (3) the compound of the present invention achieves an anesthetic effect with faster recovery.

The invention provides a heterocyclic compound and a pharmaceutical composition and application thereof, and belongs to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

The present invention relates to the technical field of medical devices, and specifically to a medical anesthesia machine capable of preventing anesthetic reflux. The present invention comprises: a main body mechanism, a drug filling mechanism and a mask mechanism. The main body mechanism comprises a columnar shell and a support frame. An anti-skid column is fixedly installed on the top of the columnar shell, an anesthetic treatment medicine tube is installed on the anti-skid column, an anesthetic treatment medicine tube is fixedly connected to the inner wall of the anesthetic treatment medicine tube with an anesthetic evaporator, and a sealing plug is slidably embedded between the anesthetic treatment medicine tube and the anesthetic evaporator. During the atomization anesthesia process, the present invention can coordinate the operation of various components of the device through an automated control system according to the patient's inhalation and exhalation states, push the atomized anesthetic gas to be delivered to the mask for the patient to inhale during inhalation, stop the delivery in time and close the corresponding passage during exhalation, so that the anesthetic delivery is synchronized with the patient's breathing, which not only ensures the anesthesia effect but also greatly reduces the possibility of anesthetic reflux caused by reverse pressure difference.

The application discloses a monitoring and regulation system and method for an anesthesia maintenance period, and the system comprises: a database for storing vital sign data and drug injection data of the whole process of the anesthesia maintenance period; and an anesthesia auxiliary platform configured with a monitoring and regulation model, which is used for intelligent regulation of an anesthesia cycle in the anesthesia maintenance period and provision of an anesthesia maintenance strategy. The application performs real-time monitoring on basic life functions of a human body in the anesthesia maintenance period, combines an anesthesia drug artificial intelligence intelligent regulation model, intelligently evaluates anesthesia risks, and intelligently regulates the dosage of anesthesia drugs, which is beneficial to control of anesthesia quality, can achieve optimal anesthesia effect by using the least anesthesia drugs, and shortens the postoperative recovery time.

The invention discloses clinical ventilation equipment for general anesthesia in the orthopedics department, relates to the technical field of anesthesia respirators, and aims to solve the problems that the gas tightness is reduced and the anesthesia effect is weakened due to the fact that the respirators fall off when a patient sideways. Suction cups adsorbed to the face of a patient are arranged on the two sides of the respirator, and an adsorption force strengthening assembly used for strengthening the adsorption effect of the suction cups is arranged on the respirator. An adjusting sliding rod on one side slides through rotation of a swing rod, an adjusting sliding block is extruded to enable an adjusting cavity to be communicated with one adjusting gas path, meanwhile, an adjusting piston slides into the adjusting cavity, gas is extruded into a connecting pipe through the adjusting gas path, the piston is extruded and driven to slide, and a suction cup piston rod in a suction cup moves; the suction effect of the suction cup on the face of the patient is enhanced, the air tightness of the respirator is improved, and the situation that the respirator falls off or a gap is generated between the respirator and the face when the patient sideways, and then the anesthesia effect is affected is prevented.

To provide an anesthesia effect prediction system and program that provide information that can be easily utilized even by an anesthesiologist with little knowledge or experience. [Solution] The anesthetic effect prediction system 1 includes an information acquisition unit 11 that acquires measurements of the biometric information of a target patient who has been administered an anesthetic, and an arithmetic processing unit 12 that predicts future changes in the biometric information of the target patient based on the measurements.

Abstract: A piperazine-substituted phenol derivative having the structure represented by formula (I) is provided. This compound not only has good salt-forming properties and excellent water solubility to meet pharmaceutical requirements, but also has a low minimum effective dose of anesthetics, rapid onset of action, and rapid recovery. This overcomes the drawbacks of prodrugs and lipid emulsion formulations of propofol and ciprofol, and is expected to be used in the preparation of drugs with sedative, hypnotic, and / or anesthetic effects and drugs for controlling status epilepticus. TIFF2025535407000076.tif41170

The utility model belongs to the technical field of animal anesthesia equipment, and particularly relates to an animal anesthesia induction box and an anesthesia system. The utility model discloses an animal anesthesia induction box, which is characterized in that a plurality of drawer boxes for placing animals are arranged in the induction box, target animals are convenient to find, the dissipation of anesthetic gas in the finding process is reduced, and independent activity spaces are separated by partition plates arranged in the drawer boxes, so that the animals are prevented from being irregularly stacked in the box. The utility model further discloses an anesthesia system which comprises the induction box, a detection device, a gas transmission device and a waste gas treatment device, the system can ensure that the concentration of anesthetic gas in the induction box is always in a stable threshold range, the anesthesia effect is improved, and environmental pollution is reduced.

The invention provides a heterocyclic compound and a pharmaceutical composition and application thereof, and belongs to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

Provided in the present invention are a heterocyclic compound and the use thereof, belonging to the technical field of pharmaceutical chemistry. A series of heterocyclic compounds prepared in the present invention have highly efficient sedative, hypnotic, and / or anesthetic effects, can control status epilepticus, and also have analgesic effects, thus providing a new option for the clinical preparation of a drug having analgesic effects, a drug having anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus, and a drug having anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus which also has analgesic effects.

The utility model discloses an anesthetic liquid sprayer, which relates to the technical field of anesthesiology department and comprises a liquid sprayer body, the bottom of the liquid sprayer body is fixedly connected with a temperature control component, the top of the liquid sprayer body is fixedly connected with a plugging component, and the inner side wall of the plugging component is fixedly connected with a miniature water pump component. The top of the micro water pump assembly is fixedly connected with a connecting pipeline, one side of the connecting pipeline is in threaded connection with a connecting opening, and a filtering assembly is inserted into the inner side wall of the connecting opening; through the arrangement of the filtering assembly and the connecting port, the filtering effect is achieved in the using process, the filtering net in the filtering frame can effectively remove impurities in anesthetic liquid, the impurities are prevented from blocking the spraying head or affecting the anesthetic effect, it is guaranteed that the sprayed anesthetic liquid is pure, infection to a patient is avoided, and therefore the effectiveness and stability of anesthesia are guaranteed; and the filtering assembly can be regularly replaced through the connecting port.

The application discloses a kind of perioperative body temperature management method and system, it is related to medical health data processing technical field, including decision unit, calculation unit, communication unit, body temperature acquisition unit, artificial input unit, temperature control heating unit etc..Based on multiple data, an efficient, fast response mathematical model is established, the intelligent decision adjustment of body temperature is realized, and the burden of medical staff during operation is reduced;Reduce the risk of postoperative complications, improve the effect of anesthesia and recovery quality, reduce postoperative chills and delayed recovery, improve the comfort and satisfaction of patients;Through effective body temperature and health information management, the rehabilitation of patients after operation can be promoted, thereby shortening the hospitalization time and saving medical resources;Through intelligent, individualized body temperature prediction and intervention technology, higher quality perioperative management is realized, which helps to promote the development of precision medicine.

The invention relates to an adjustable spraying device for clinical anesthesia in the anesthesiology department, and belongs to the technical field of medical instruments. In order to enable anesthetics to accurately and efficiently reach a target anesthesia area, the adjustable and controllable spraying device for clinical anesthesia in the anesthesiology department comprises a spraying pipe and an air curtain assembly, the spraying pipe comprises an inner pipe and an outer pipe, a plurality of spraying holes are formed in the tail end of the inner pipe, the inner pipe is sleeved with the outer pipe, and an air conveying cavity communicated with an air pump is formed between the outer pipe and the inner pipe; the air curtain assembly comprises an elastic cylinder arranged in the air conveying cavity, one end of the elastic cylinder is configured to move in the direction close to or away from the inner pipe so as to change the flowing direction and the flowing range of airflow in the air conveying cavity, and the other end of the elastic cylinder is slidably connected with the inner pipe. The air curtain assembly can control the anesthetic spraying direction and spraying range, the anesthetic can accurately and efficiently reach the target anesthesia area, the spraying range is controlled within the target anesthesia area, anesthetic waste is reduced, and the anesthesia effect and anesthesia safety are improved.

The present invention belongs to the technical field of medicine. Provided are a compound, and a preparation method therefor and the use thereof. The compound has a structure as shown in formula I. The compound of the present invention not only has efficient sedative, hypnotic and / or anesthetic effects, and the ability to control status epilepticus, but also exhibits an analgesic effect, and can reduce or avoid the use of opioid analgesics such as fentanyl, alfentanil, sufentanil or remifentanil in clinical application, thereby reducing the occurrence of adverse reactions such as circulatory depression, respiratory depression, urinary retention and pruritus caused by opioid analgesics.

The invention provides a urethra low-irritation double-layer gel anesthetic and a preparation method thereof.The anesthetic comprises a first gel layer, a second gel layer and a third gel layer, the first gel layer comprises a local anesthetic and a temperature-sensitive reversible gel matrix, and the temperature-sensitive reversible gel matrix is subjected to sol-gel transition at 25-40 DEG C; the second gel layer comprises aloe polysaccharide and an irreversible gel skeleton, and the irreversible gel skeleton is formed by a polysaccharide gel agent; wherein the first gel layer and the second gel layer are physically compounded at an interface to form a double-layer whole. According to the double-layer gel anesthetic, the local anesthetic and the temperature-sensitive reversible gel matrix are compounded, gel can be rapidly formed under the body temperature condition, it is guaranteed that the drug fully stays and slowly releases in the local part of the urethra, and the anesthetic effect is remarkably improved.

The invention relates to the technical field of medicines, and particularly discloses compound lidocaine cream as well as a preparation method and application thereof. The invention provides compound lidocaine emulsifiable paste. The compound lidocaine emulsifiable paste is specifically prepared from the following components in parts by weight: 22 to 26 parts of lidocaine, 22 to 26 parts of prilocaine, 13 to 17 parts of solubilizer, 9 to 11 parts of carbomer, 3 to 5 parts of sodium hydroxide and 0.02 to 0.06 part of penetration enhancer, the total amount is 1000 parts. The solubilizer is formed by mixing polyoxyethylene hydrogenated castor oil and poloxamer 188 in a weight ratio of (10-15): (1-4); the penetration enhancer is prepared by mixing L-ethyl lactate and oleic acid in a weight ratio of (1-4): (0.2-1). The compound lidocaine emulsifiable paste prepared by the invention has good safety, and the compound lidocaine emulsifiable paste has the effects of quicker effect taking, deeper anesthetic effect and longer duration time.

The present invention relates to the field of pharmaceutical chemistry, and discloses flavonoid derivatives, preparation methods thereof, pharmaceutical compositions, and applications thereof. The general structural formula of the flavonoid derivatives is: wherein R2 and R'2 are independently selected from -H, -OH, or -OCH3; R3 and R'3 are independently selected from -H, -CH3, -OCH3, -CH(CH3)2, or -CH(CH2)2; R5 and R'5 are independently selected from -H, -CH3, -OCH3, -CH(CH3)2, or -CH(CH2)2; R6 and R'6 are independently selected from -H, -OH, or -OCH3. The flavonoid derivatives have enhanced lipid solubility, facilitate BBB penetration, increase drug concentration in the brain, maintain pharmacokinetic levels, effectively retain neuroprotective effects such as anti-oxidative stress, anti-inflammatory, and neuroregeneration, and introduce propofol into the flavonoid skeleton to enhance the anesthetic effect under the synergistic effect of the two, making them a potential new antidepressant drug.

The utility model discloses a novel anaesthetic mask for rats, which relates to the technical field of animal anaesthetic masks and comprises an air inlet pipe, one end of the air inlet pipe is fixedly connected with a fixing ring, the outside of the fixing ring is fixedly connected with a communicating pipe, one end of the communicating pipe is fixedly connected with a ventilating balloon, and the other end of the communicating pipe is fixedly connected with an air outlet pipe. A plurality of ventilation holes are formed in the outer surface of the ventilation balloon, and the ventilation balloon is arranged in the oral cavity of the rat. When a rat needs to be anesthetized, firstly, the head of the rat penetrates through the sleeve opening and enters the soft mask, then the ventilation ball is arranged in the oral cavity of the rat, the lower incisor of the rat is clamped in the clamping opening formed in the middle of the fixing ring, and the soft mask and the rat are fixed through the effect of the binding belt. Then anesthetic gas can be introduced through the air inlet pipe and directly enters the oral cavity of the rat through the air inlet pipe, the fixing ring, the communicating pipe, the ventilating ball and the ventilating hole, and the problem that the anesthetic effect is affected due to anesthetic gas leakage is solved.

The invention discloses a local anesthetic spraying device capable of improving operation stability for the anesthesiology department, and belongs to the field of medical instruments, a storage cylinder for containing anesthetic liquid is provided, a spraying assembly is arranged on the storage cylinder, and the spraying assembly is used for switching sprayers with different precisions to spray an affected part; the driving assembly is arranged in the storage cylinder, the driving assembly is used for stably extruding the anesthetic liquid medicine in the storage cylinder, and meanwhile, the spraying dosage can be set; the adding assembly is arranged on the storage cylinder; the spraying assembly adapts to different anesthesia scenes by switching sprayers with different precisions, liquid medicine spraying is more targeted, the driving assembly extrudes the liquid medicine through stable power output, force fluctuation of manual pressing is avoided, meanwhile, through the dose setting function, it is ensured that the amount of the liquid medicine sprayed every time is consistent, and the spraying efficiency is improved. Influence of anesthesia effect caused by insufficient dosage or adverse reaction caused by excessive dosage are avoided.

This invention provides an upper respiratory tract surface anesthesia device, belonging to the technical field of anesthesia devices. Its features include an inlet pipe, a connecting pipe, and a spray nozzle. The lower end of the inlet pipe is connected to the connecting pipe via a flexible tube for connecting to an external drug or air supply line. An adjusting rod is slidably fitted on the outer side of the inlet pipe. The upper end of the inlet pipe has a conical tube, and a movable sleeve rod is movably fitted on the outer side of the conical tube. The spray nozzle is located at the upper end of the conical tube for spraying anesthetic liquid. The upper end of the conical tube has a sealing sleeve, and the inner side of the sealing sleeve has a support rod. The upper end of the adjusting rod has an ear plate, and the inner side of the ear plate is rotatably connected to a connecting rod that is rotatably connected to the movable sleeve rod. This allows the adjusting rod to adjust the angle of the support rod to cooperate with the sealing sleeve in sealing the airway. The advantages of this invention are: effective sealing of the target airway, prevention of drug leakage, significantly improved drug utilization and anesthetic effect, and convenient operation.

The invention belongs to the technical field of medical instruments, and particularly relates to a drug delivery device and a method thereof.The drug delivery device comprises a central control board, an anesthesia pump unit is connected with the central control board and used for delivering anesthetic drugs according to an anesthesia plan preset by a doctor, and a physiological monitoring unit is connected with the central control board and used for monitoring the anesthetic drugs. The anesthesia pump unit is used for monitoring vital signs, heart rate, blood pressure, respiration, body temperature, oxygen saturation and electroencephalogram of a patient in real time to evaluate the anesthesia depth, generating first data information and transmitting the first data information to the central control board, the anesthesia pump unit is combined with the monitoring system, and the vital signs and brain waves of the patient are monitored in real time through multiple feedback mechanisms; according to the anesthesia depth and physiological parameters of a patient, the administration amount and the administration rate of the medicine are adjusted in real time, accurate control over the anesthesia effect is ensured, the anesthetic medicine is safely and efficiently released in the whole process, the anesthesia depth is prevented from being too large or too small, and the manual operation risk is reduced.

The present invention belongs to the technical field of medicine. Provided are a compound, and a preparation method therefor and the use thereof. The compound has a structure as shown in formula I. The compound of the present invention not only has efficient sedative, hypnotic and / or anesthetic effects, and can control status epilepticus, but also has an analgesic effect, and can reduce or avoid the use of opioid analgesics such as fentanyl, alfentanil, sufentanil or remifentanil in clinical application, thereby reducing the occurrence of adverse reactions such as circulatory inhibition, respiratory inhibition, urinary retention and pruritus caused by opioid analgesics.

The invention relates to a novel cyclic quaternary ammonium salt compound as well as a preparation method and application thereof. The invention provides a compound as shown in a formula (I), or a deuterated compound, a solvate or a pharmaceutically acceptable salt thereof. The cyclic quaternary ammonium salt compound has a long-acting anesthetic effect, and the compound and the composition thereof can prolong the anesthetic action time and relieve postoperative pain and chronic pain.

The invention belongs to the technical field of anesthetic drugs, and particularly relates to an anesthetic drug and a preparation method thereof. The anesthetic is prepared by mixing 1000 parts by weight of bupivacaine liposome injection, 0.5-1 part by weight of magnesium sulfate and 3-5 parts by weight of dexmedetomidine hydrochloride. Wherein magnesium sulfate and dexmedetomidine hydrochloride are auxiliary agents, so that the anesthesia onset time is shortened. The anesthetic prepared by the invention is smaller in side effect, quick in effect taking and long in maintenance time, the injection frequency of the anesthetic can be reduced, the infection risk and the nursing cost can be reduced, the anesthetic effect is good, and the application prospect is wide.

The utility model discloses a mouse anesthesia device which comprises a mask cylinder, a mask cover, a mask cover, a mask cover, a mask cover, a mask cover, a mask cover and a mask cover which are sequentially arranged from front to back, and the mask cover is a conical cylinder body and is provided with a covering space above the neck of a mouse; the medicine feeding cylinder is a cylindrical cylinder body, the middle part of the cylinder body of the medicine feeding cylinder is connected with a medicine feeding head through a medicine feeding pipe, and a medicine feeding valve is arranged at the front part of the cylinder body of the medicine feeding cylinder; an air inlet valve is arranged in the middle of a cylinder body of the air inlet cylinder, and a compression fan is arranged on the rear portion of the cylinder body of the air inlet cylinder. The mouse can be fixed, residual anesthetic is fully fed into the mouse mouth and nose rear isolation mask cylinder through air after anesthesia is completed, the anesthesia effect is improved, volatilization and seepage of the anesthetic are reduced, operation is easy, carrying is convenient, and environmental pollution is reduced.

A piperazine substituted phenol derivative and its applications in pharmaceutical chemistry are provided. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum effective anesthetic dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and / or anesthetic effects, as well as in drugs for controlling status epilepticus.

The invention relates to the field of anesthetics for experiments, and discloses a novel long-period steady-state composite anesthetic for mouse cranial nervous system experiments, a kit comprises a penicillin bottle filled with freeze-dried powder and an ampoule bottle filled with a redissolving medium; the freeze-dried powder is prepared by freeze-drying teletamine, zolazepam, cylazine, hyaluronidase and a medicinal excipient. According to the invention, the composite anesthetic is prepared into a stable freeze-dried dosage form, so that the technical problems that the existing similar anesthetic aqueous solution is unstable in chemical property, needs to be prepared temporarily and is inaccurate in dosage are solved, and the storage stability and the use convenience of the product are improved. The hyaluronidase is introduced into the components, so that the rapid and uniform absorption of the medicine is promoted, the anesthesia induction time is effectively shortened, the individual difference is reduced, and the anesthesia effect is more uniform and controllable. The composite anesthetic provided by the invention has stable anesthesia maintenance time of more than 100 minutes, and is especially suitable for long-term precision surgical experiments such as brain stereotactic injection and the like in brain nervous system research.