80 results about "Anesthetic Effect" patented technology

The invention belongs to the technical field of medical and mechanical combinations, and discloses a high-permeability and low-sensitivity ripdicaine wound patch and a preparation method thereof.The high-permeability and low-sensitivity ripdicaine wound patch comprises a wound patch body, and the wound patch body is prepared from, by mass, 0.1%-0.4% of sodium hyaluronate, 1.5%-3.5% of lidocaine, 1.5%-3.5% of prilocaine, 3%-10% of solvent, 0.5%-8% of emulsifier, 2%-10% of humectant, 0.1%-5% of soothing agent, 0.1%-1.5% of stabilizer, 0.1%-1% of thickener and the balance water. According to the present invention, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, and the total amount of the raw materials is 100%. And the anesthetic has the advantages of quick effect taking, low sensitivity, capability of resisting moist heat sterilization and good stability.

The present invention relates to the technical field of pharmaceutical chemistry, and provides a heterocyclic compound and a pharmaceutical use thereof. The structure of the heterocyclic compound is as shown in formula II. The compound of the present invention has high-efficiency sedative, hypnotic and / or anesthetic effects, can control status epilepticus, and also has an analgesic effect, providing a new choice for clinical preparation of a drug having the analgesic effect, a drug having the anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus, and a drug having both the anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus and also having the analgesic effect.

The invention discloses an anesthesia effect prediction method based on a graph neural network. The method comprises the following steps: obtaining a standardized synchronization time sequence data set; forming a time sliding window sequence; generating an initial topology of the dynamic physiological index-drug effect variable diagram structure; generating a node initial feature representation set for each graph node, and initializing a graph neural network model parameter set; obtaining an updated dynamic physiological index-drug effect variable diagram structure; inputting the pharmacodynamic variable graph structure into a graph neural network model corresponding to the graph neural network model parameter set to obtain a node embedding representation set and an edge embedding representation set; outputting an induction period anesthesia effect prediction result set; and generating an interpretable output result set, wherein the interpretable output result set comprises a key variable link, a dominant influence factor and a drug administration adjustment suggestion. The rapid detection capability of the abnormal state in the induction period is improved.

The invention provides a surface anesthesia application and a preparation method thereof, and belongs to the technical field of application. The surface anesthesia application is composed of a base material and anesthetic liquid, and the anesthetic liquid is prepared from, by mass, 0.5-10% of anesthetic, 0-1% of sodium hyaluronate, 0.1-10% of penetration enhancer, 0.1-1% of thickening agent, 0.01-0.5% of pH value regulator, 0.1-1% of preservative, 0-5% of emulsifier and the balance water. The surface anesthesia application prepared by the invention takes effect quickly, has a good anesthesia effect, reduces the dosage of anesthetics, and is convenient to use and low in cost.

Disclosed in the present invention are a benzodiazepine compound, a pharmaceutical composition and the use thereof. Specifically provided is a compound represented by formula I, or a stereoisomer thereof, a deuterated compound thereof, or a pharmaceutically acceptable salt thereof. The compound provided in the present invention has one or more of the following advantageous effects: (1) the compound of the present invention exhibits good intravenous sedative and anesthetic effects; (2) the compound of the present invention exhibits low drug accumulation and a good tolerance; and (3) the compound of the present invention achieves an anesthetic effect with faster recovery.

The present invention relates to the technical field of pharmaceutical chemistry, and provides a heterocyclic compound and a use thereof. The structure of the heterocyclic compound is as shown in formula II. The compound of the present invention has efficient sedative, hypnotic and / or anesthetic effects, can control the status epilepticus, further has an analgesic effect, and provides a new option for clinically preparing a drug having an analgesic effect, a drug having anesthetic, sedative and hypnotic effects and / or capable of controlling the status epilepticus, and a drug having anesthetic, sedative and hypnotic effects and / or capable of controlling the status epilepticus and also having the analgesic effect.

The invention provides a heterocyclic compound and a pharmaceutical composition and application thereof, and belongs to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

The present invention relates to the technical field of medical devices, and specifically to a medical anesthesia machine capable of preventing anesthetic reflux. The present invention comprises: a main body mechanism, a drug filling mechanism and a mask mechanism. The main body mechanism comprises a columnar shell and a support frame. An anti-skid column is fixedly installed on the top of the columnar shell, an anesthetic treatment medicine tube is installed on the anti-skid column, an anesthetic treatment medicine tube is fixedly connected to the inner wall of the anesthetic treatment medicine tube with an anesthetic evaporator, and a sealing plug is slidably embedded between the anesthetic treatment medicine tube and the anesthetic evaporator. During the atomization anesthesia process, the present invention can coordinate the operation of various components of the device through an automated control system according to the patient's inhalation and exhalation states, push the atomized anesthetic gas to be delivered to the mask for the patient to inhale during inhalation, stop the delivery in time and close the corresponding passage during exhalation, so that the anesthetic delivery is synchronized with the patient's breathing, which not only ensures the anesthesia effect but also greatly reduces the possibility of anesthetic reflux caused by reverse pressure difference.

The present invention relates to a soluble microneedle for local anesthesia and a local anesthesia patch comprising same, the soluble microneedle comprising an amide-based local anesthetic, hyaluronic acid, and polyvinylpyrrolidone in a specific content ratio. The present invention uses the soluble microneedle to implement direct drug delivery by physically permeating through the stratum corneum and mucosa, and thus a precise and rapid anesthetic effect may be exhibited. Especially, the microneedle comprising a specific amount of polyvinylpyrrolidone is dissolved, and the anesthetic contained in the microneedle is rapidly delivered to nerve cells, and thus the disadvantage of a long waiting time of conventional anesthetic creams may be overcome, and thus the present invention has the advantage of being usable in various ways in dental, dermatology, and other surgical procedures requiring local anesthesia.

The invention discloses a dexmedetomidine and propofol combined reagent and a combination method, and relates to the technical field of combined use of anesthetic drugs. According to the method, firstly, dexmedetomidine is subjected to intravenous pump injection within 5-15 minutes according to the dosage of 0.5-1.0 mu g / kg, propofol is given within 2 minutes after the dexmedetomidine is subjected to general anesthesia, and the dosage of the propofol can be reduced by 10%-50% compared with that of propofol which is independently used. Through pretreatment of dexmedetomidine, the anesthetic effect of propofol can be enhanced, adverse reactions such as blood pressure drop and respiratory depression can be effectively reduced, and anesthetic safety and controllability are improved. The combined reagent comprises independent containers for respectively loading the dexmedetomidine injection and the propofol emulsion, and can be packaged by adopting a double-cavity pre-filled injector, and sequential injection is realized through a controllable opening mechanism, so that unstable emulsification and titer change caused by physical mixing of medicines are avoided.

The application discloses a monitoring and regulation system and method for an anesthesia maintenance period, and the system comprises: a database for storing vital sign data and drug injection data of the whole process of the anesthesia maintenance period; and an anesthesia auxiliary platform configured with a monitoring and regulation model, which is used for intelligent regulation of an anesthesia cycle in the anesthesia maintenance period and provision of an anesthesia maintenance strategy. The application performs real-time monitoring on basic life functions of a human body in the anesthesia maintenance period, combines an anesthesia drug artificial intelligence intelligent regulation model, intelligently evaluates anesthesia risks, and intelligently regulates the dosage of anesthesia drugs, which is beneficial to control of anesthesia quality, can achieve optimal anesthesia effect by using the least anesthesia drugs, and shortens the postoperative recovery time.

The present invention belongs to the technical field of biomedicine, and particularly relates to an anesthetic preparation containing trimecaine and a preparation method thereof. The anesthetic preparation containing trimecaine comprises the following raw materials in parts by weight: 8-12 parts of trimecaine, 0.5-1 part of lindenenolide, 0.3-0.8 part of sodium phytate, 1-5 parts of schizophyllan oligosaccharide, 3-5 parts of 1,2-propanediol, 2-6 parts of sodium carboxymethylcellulose, 3-8 parts of Tween, and 60-70 parts of physiological saline. The combination of lindenenolide and trimecaine added in the anesthetic preparation of the present invention can improve the anesthetic effect and prolong the anesthetic time. Sodium phytate and schizophyllan oligosaccharide in the anesthetic preparation act synergistically to effectively improve the stability of the anesthetic preparation. Among them, due to the film-forming property of schizophyllan oligosaccharide, it can also improve the anesthetic efficacy of the anesthetic preparation to a certain extent. In addition, the anesthetic prepared by the present invention has no obvious irritation to the skin.

The invention discloses clinical ventilation equipment for general anesthesia in the orthopedics department, relates to the technical field of anesthesia respirators, and aims to solve the problems that the gas tightness is reduced and the anesthesia effect is weakened due to the fact that the respirators fall off when a patient sideways. Suction cups adsorbed to the face of a patient are arranged on the two sides of the respirator, and an adsorption force strengthening assembly used for strengthening the adsorption effect of the suction cups is arranged on the respirator. An adjusting sliding rod on one side slides through rotation of a swing rod, an adjusting sliding block is extruded to enable an adjusting cavity to be communicated with one adjusting gas path, meanwhile, an adjusting piston slides into the adjusting cavity, gas is extruded into a connecting pipe through the adjusting gas path, the piston is extruded and driven to slide, and a suction cup piston rod in a suction cup moves; the suction effect of the suction cup on the face of the patient is enhanced, the air tightness of the respirator is improved, and the situation that the respirator falls off or a gap is generated between the respirator and the face when the patient sideways, and then the anesthesia effect is affected is prevented.

The invention belongs to the technical field of medical equipment, and particularly relates to an anesthetic needle inserting device for the anesthesiology department, the anesthetic needle inserting device comprises a control assembly, the control assembly is sequentially provided with a pushing assembly, a limiting assembly and a clamping assembly, the pushing assembly comprises a pushing frame, the pushing frame is provided with a sliding groove, one side of the pushing frame is fixedly connected with a clamping plate, and the clamping plate is fixedly connected with the limiting assembly. The clamping assembly comprises a clamping block, one side of the clamping block is fixedly connected with a sliding rod, one end of the sliding rod is fixedly connected with a limiting rod, an injector is clamped in the clamping block, the position of the limiting plate is accurately adjusted, the needle inserting length of the injector can be controlled, an anesthesia point can be conveniently and more accurately positioned in the anesthesia process, and the anesthesia accuracy is improved. The anesthesia effect is improved, and the problem that the anesthesia effect is poor due to the fact that the needle inserting depths are inconsistent is solved.

The invention discloses a perioperative period body temperature management method and system, and relates to the technical field of medical health data processing, and the system comprises a decision unit, a calculation unit, a communication unit, a body temperature acquisition unit, a manual input unit, a temperature control heating unit and the like. Based on multivariate data, a mathematical model which is efficient and high in response speed is established, intelligent decision-making adjustment of the body temperature is achieved, and the burden of medical staff in an operation is reduced; the risk of postoperative complications is reduced, the anesthesia effect and the recovery quality are improved, postoperative shivering and delayed waking are reduced, and the comfort and the satisfaction degree of a patient are improved; through effective body temperature and health information management, postoperative rehabilitation of a patient can be promoted, so that the hospitalization time is shortened, and medical resources are saved; and through an intelligent and individualized body temperature prediction and intervention technology, higher-quality perioperative period management is realized, and the development of precise medical treatment is promoted.

To provide an anesthesia effect prediction system and program that provide information that can be easily utilized even by an anesthesiologist with little knowledge or experience. [Solution] The anesthetic effect prediction system 1 includes an information acquisition unit 11 that acquires measurements of the biometric information of a target patient who has been administered an anesthetic, and an arithmetic processing unit 12 that predicts future changes in the biometric information of the target patient based on the measurements.

The utility model relates to the technical field of inhalation masks for the anesthesiology department, and discloses a conveniently fixed inhalation mask for the anesthesiology department, which comprises a mask body, a left ear hanging belt and a right ear hanging belt, both sides of the mask body are provided with air outlets, the outlets of the air outlets are provided with filter covers, the inside of the mask body is connected with an air inlet pipe in a penetrating manner, and the left ear hanging belt is connected with the right ear hanging belt. An air inlet pipe is arranged in the mask body, a protective net is arranged in the air inlet pipe, a mounting seat is fixedly connected to the inner side face of the mask body, a nasal cavity protective cover is arranged on the mounting seat, the left ear hanging belt and the right ear hanging belt are fixedly connected with the mask body, a second fastening belt is fixedly connected to the left ear hanging belt, and a first fastening belt is fixedly connected to the right ear hanging belt. The first fastening belt is connected with the hook-and-loop fastener through the hook-and-loop fastener, the mask body can be better fixed to the face of the patient, meanwhile, the mask body is convenient to disassemble, anesthetic can be better inhaled through the nasal cavity of the patient, the anesthetic is not prone to loss, and the anesthetic effect is improved.

Abstract: A piperazine-substituted phenol derivative having the structure represented by formula (I) is provided. This compound not only has good salt-forming properties and excellent water solubility to meet pharmaceutical requirements, but also has a low minimum effective dose of anesthetics, rapid onset of action, and rapid recovery. This overcomes the drawbacks of prodrugs and lipid emulsion formulations of propofol and ciprofol, and is expected to be used in the preparation of drugs with sedative, hypnotic, and / or anesthetic effects and drugs for controlling status epilepticus. TIFF2025535407000076.tif41170

The utility model belongs to the technical field of animal anesthesia equipment, and particularly relates to an animal anesthesia induction box and an anesthesia system. The utility model discloses an animal anesthesia induction box, which is characterized in that a plurality of drawer boxes for placing animals are arranged in the induction box, target animals are convenient to find, the dissipation of anesthetic gas in the finding process is reduced, and independent activity spaces are separated by partition plates arranged in the drawer boxes, so that the animals are prevented from being irregularly stacked in the box. The utility model further discloses an anesthesia system which comprises the induction box, a detection device, a gas transmission device and a waste gas treatment device, the system can ensure that the concentration of anesthetic gas in the induction box is always in a stable threshold range, the anesthesia effect is improved, and environmental pollution is reduced.

The utility model relates to the field of spraying devices, and discloses an anesthetic spraying device which comprises a spraying box, the left side of the top of the spraying box is slidably connected with a drawing rod, the bottom of the drawing rod is fixedly connected with a piston, and the top of the inner wall of the spraying box is fixedly connected with a metering box. A one-way valve is fixedly connected to the bottom of the inner wall of the metering box, a spraying pipe is fixedly connected to the outer wall of the left side of the spraying box and penetrates through the inner wall of the left side of the metering box, a spraying head is slidably connected to the right side of the spraying pipe, buckles are fixedly connected to the four sides of the left end of the spraying head, and springs are fixedly connected to the inner walls of the left ends of the buckles; the upper side and the lower side of the spring are fixedly connected with clamping blocks, and the clamping blocks are in sliding connection with the inner wall of the buckle. According to the utility model, the dosage of anesthetic can be accurately controlled, so that the anesthetic effect is good, the discomfort of a patient to the anesthetic effect is reduced, and the spray head is conveniently replaced to face different scenes.

The invention provides a heterocyclic compound and a pharmaceutical composition and application thereof, and belongs to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

Provided in the present invention are a heterocyclic compound and the use thereof, belonging to the technical field of pharmaceutical chemistry. A series of heterocyclic compounds prepared in the present invention have highly efficient sedative, hypnotic, and / or anesthetic effects, can control status epilepticus, and also have analgesic effects, thus providing a new option for the clinical preparation of a drug having analgesic effects, a drug having anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus, and a drug having anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus which also has analgesic effects.

The utility model discloses an anesthetic liquid sprayer, which relates to the technical field of anesthesiology department and comprises a liquid sprayer body, the bottom of the liquid sprayer body is fixedly connected with a temperature control component, the top of the liquid sprayer body is fixedly connected with a plugging component, and the inner side wall of the plugging component is fixedly connected with a miniature water pump component. The top of the micro water pump assembly is fixedly connected with a connecting pipeline, one side of the connecting pipeline is in threaded connection with a connecting opening, and a filtering assembly is inserted into the inner side wall of the connecting opening; through the arrangement of the filtering assembly and the connecting port, the filtering effect is achieved in the using process, the filtering net in the filtering frame can effectively remove impurities in anesthetic liquid, the impurities are prevented from blocking the spraying head or affecting the anesthetic effect, it is guaranteed that the sprayed anesthetic liquid is pure, infection to a patient is avoided, and therefore the effectiveness and stability of anesthesia are guaranteed; and the filtering assembly can be regularly replaced through the connecting port.

The application discloses a kind of perioperative body temperature management method and system, it is related to medical health data processing technical field, including decision unit, calculation unit, communication unit, body temperature acquisition unit, artificial input unit, temperature control heating unit etc..Based on multiple data, an efficient, fast response mathematical model is established, the intelligent decision adjustment of body temperature is realized, and the burden of medical staff during operation is reduced;Reduce the risk of postoperative complications, improve the effect of anesthesia and recovery quality, reduce postoperative chills and delayed recovery, improve the comfort and satisfaction of patients;Through effective body temperature and health information management, the rehabilitation of patients after operation can be promoted, thereby shortening the hospitalization time and saving medical resources;Through intelligent, individualized body temperature prediction and intervention technology, higher quality perioperative management is realized, which helps to promote the development of precision medicine.

The invention relates to an adjustable spraying device for clinical anesthesia in the anesthesiology department, and belongs to the technical field of medical instruments. In order to enable anesthetics to accurately and efficiently reach a target anesthesia area, the adjustable and controllable spraying device for clinical anesthesia in the anesthesiology department comprises a spraying pipe and an air curtain assembly, the spraying pipe comprises an inner pipe and an outer pipe, a plurality of spraying holes are formed in the tail end of the inner pipe, the inner pipe is sleeved with the outer pipe, and an air conveying cavity communicated with an air pump is formed between the outer pipe and the inner pipe; the air curtain assembly comprises an elastic cylinder arranged in the air conveying cavity, one end of the elastic cylinder is configured to move in the direction close to or away from the inner pipe so as to change the flowing direction and the flowing range of airflow in the air conveying cavity, and the other end of the elastic cylinder is slidably connected with the inner pipe. The air curtain assembly can control the anesthetic spraying direction and spraying range, the anesthetic can accurately and efficiently reach the target anesthesia area, the spraying range is controlled within the target anesthesia area, anesthetic waste is reduced, and the anesthesia effect and anesthesia safety are improved.

The utility model relates to the technical field of medical equipment, in particular to a respirator mask for anesthesia, which comprises a frame, a connecting frame is clamped on the inner side of the frame, a pipeline connector is clamped on the front side of the frame, a fixing block is fixedly connected to the top of the connecting frame, a sliding groove is arranged on the side edge of the fixing block, and a connecting rod is arranged in the sliding groove. A plurality of second clamping grooves are formed in the sliding groove, a connecting block is slidably connected to the outer side wall of the fixing block, a sliding block is fixedly connected to the inner side of the connecting block, a second spring is arranged in the sliding block, a clamping column is fixedly connected to the side edge of the second spring, and an inflatable cushion is arranged at the bottom of the connecting frame. An inflation hole is formed in the top of the inflatable cushion; the anesthesia frame has the beneficial effects that through the arrangement of the inflatable cushion and the inflation hole, when the frame is fixed to the human face, the inflatable cushion is inflated, so that the inflatable cushion is tightly attached to the cheek of the human face, and the situation that anesthetic leaks, and a patient cannot achieve the existing anesthesia effect is avoided.

The present invention belongs to the technical field of medicine. Provided are a compound, and a preparation method therefor and the use thereof. The compound has a structure as shown in formula I. The compound of the present invention not only has efficient sedative, hypnotic and / or anesthetic effects, and the ability to control status epilepticus, but also exhibits an analgesic effect, and can reduce or avoid the use of opioid analgesics such as fentanyl, alfentanil, sufentanil or remifentanil in clinical application, thereby reducing the occurrence of adverse reactions such as circulatory depression, respiratory depression, urinary retention and pruritus caused by opioid analgesics.

The invention discloses a preparation method of an anesthetic taking effect quickly and lasting for a long time. The preparation method comprises the following steps: S1, heating and dissolving a slow-release local anesthetic and an oil phase matrix, cooling, and adding an antioxidant and an emulsifier to form an oil phase; s2, heating the water-phase matrix, adding the bacteriostatic agent, dissolving, cooling, respectively adding the quick-release local anesthetic, the pH regulator, the chelating agent and the film-forming agent, and dissolving to obtain a water phase; s3, under high-speed shearing, the water phase is slowly added into the oil phase, after high-speed shearing and mixing, the thickening agent is added, and filling is carried out, so that the anesthetic is obtained.The prepared anesthetic can form a film for administration during use, no residual medicine adheres to the anesthetic after the film is removed, meanwhile, the anesthetic takes effect quickly and lasts for a long time, the controllability of the anesthetic effect is enhanced, and the experience feeling and satisfaction degree of a user are improved; and the product can be stored at room temperature for more than 12 months.

The invention provides a urethra low-irritation double-layer gel anesthetic and a preparation method thereof.The anesthetic comprises a first gel layer, a second gel layer and a third gel layer, the first gel layer comprises a local anesthetic and a temperature-sensitive reversible gel matrix, and the temperature-sensitive reversible gel matrix is subjected to sol-gel transition at 25-40 DEG C; the second gel layer comprises aloe polysaccharide and an irreversible gel skeleton, and the irreversible gel skeleton is formed by a polysaccharide gel agent; wherein the first gel layer and the second gel layer are physically compounded at an interface to form a double-layer whole. According to the double-layer gel anesthetic, the local anesthetic and the temperature-sensitive reversible gel matrix are compounded, gel can be rapidly formed under the body temperature condition, it is guaranteed that the drug fully stays and slowly releases in the local part of the urethra, and the anesthetic effect is remarkably improved.

The invention relates to the technical field of medicines, and particularly discloses compound lidocaine cream as well as a preparation method and application thereof. The invention provides compound lidocaine emulsifiable paste. The compound lidocaine emulsifiable paste is specifically prepared from the following components in parts by weight: 22 to 26 parts of lidocaine, 22 to 26 parts of prilocaine, 13 to 17 parts of solubilizer, 9 to 11 parts of carbomer, 3 to 5 parts of sodium hydroxide and 0.02 to 0.06 part of penetration enhancer, the total amount is 1000 parts. The solubilizer is formed by mixing polyoxyethylene hydrogenated castor oil and poloxamer 188 in a weight ratio of (10-15): (1-4); the penetration enhancer is prepared by mixing L-ethyl lactate and oleic acid in a weight ratio of (1-4): (0.2-1). The compound lidocaine emulsifiable paste prepared by the invention has good safety, and the compound lidocaine emulsifiable paste has the effects of quicker effect taking, deeper anesthetic effect and longer duration time.