15993results about "Artificial respiration" patented technology

The invention relates to a closed-loop multi-guide multi-mode time domain interference electrical stimulation system and method. The method comprises the steps that a software part determines stimulation parameters; the automatic electrode position adjusting device adjusts the spatial position of the multi-conductive-electrode device, and the multi-conductive-electrode device stimulates the position of a target spot; the current output precision and impedance monitoring module monitors the precision and impedance information of electrode output current, and the core main control and functional circuit module adjusts a control signal according to the precision and impedance information; when the multi-conducting-electrode device conducts stimulation, the electroencephalogram device synchronously collects electroencephalogram signals and uploads the electroencephalogram signals to the electroencephalogram analysis algorithm module of the software part, the electroencephalogram analysis algorithm module evaluates and feeds back the effectiveness and the effect of stimulation, and the time domain interference electrical stimulation function module and the target area dynamic adjustment algorithm module optimize stimulation parameters according to the effectiveness and the effect of stimulation. Through the arrangement, a real-time closed-loop feedback control system is formed, continuous monitoring, real-time optimization and adjustment of electrical stimulation parameters and dynamic adjustment of a stimulated brain target region are realized, and the accuracy and safety of current output are ensured.

The invention relates to the technical field of medical data processing, in particular to an integrated rehabilitation training system based on motion capture and myoelectricity feedback, which comprises a motion data acquisition module, a motion evaluation and analysis module and a control module, and is specifically integrated on a training garment through inertial motion capture equipment and a surface myoelectricity sensor. The motion state and muscle activation condition of a patient are monitored in real time, actual motion data and actual electromyographic signal data of the patient are collected, and whether the motion state of the patient meets the standard or not is judged by comparing the data deviation condition between the actual motion of the patient and the standard motion. And according to the deviation analysis result, the electrical stimulation parameters can be dynamically adjusted through closed-loop control, so that personalized and precise spinal cord electrical stimulation rehabilitation training is realized.

Provided are systems, devices, and methods for energy delivery to a patient to treat a medical condition. A system for delivering energy to a patient includes: a treatment device having one or more energy delivery elements. The treatment device can deliver energy, such as ultrasound energy, to a target location of the patient via the one or more energy delivery elements. The energy delivery to the target location treats a medical condition of the patient.

Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises burst periods and constant periods, wherein each burst period includes 2 to 20 pulses and has a duration of less than 20,000 microseconds.

Systems, devices and methods are provided for stimulating one or more nerves within a user. A system comprises stimulator having an electrode configured for contacting the outer skin surface at a target location and an energy source coupled to the stimulator, The energy source is configured to generate at least one electrical impulse and to transmit the electrical impulse transcutaneously from the electrode through the outer skin surface of the user to a selected nerve in the user. In certain aspects, the systems and methods are particularly useful for non-medical purposes, such as reducing stress and anxiety, enhancing relaxation, improving sleep, energy, concentration and mood, increasing mental or physical performance, promoting mental health, recovery and wellness, generally improving the health and wellbeing of a user and / or for temporarily or permanently improving intelligence, learning capacity, memory retention, recall, mood, alertness and / or sleep efficiency in human beings.

An in vitro training method for training genioglossus muscle strength includes adhering an electrode patch of an in vitro training device to a bottom of a chin of a user during a non-sleep period. The electrode patch receives an electrical stimulation signal from an electrical stimulation module of the in vitro training device to stimulate the genioglossus muscle of the user through transdermal electrical stimulation. The electrode patch includes a body surface adhering face and an assembling face opposite to the body surface adhering face. The body surface adhering face is adhered to the bottom of the chin of the user to align with the genioglossus muscle. The electrical stimulation module is disposed on the assembling face and in electrical connection with the electrode patch. The electrical stimulation module sends an electrical stimulation signal to stimulate the genioglossus muscle through transdermal electrical stimulation.

The systems and methods relate to cyclically inflating and deflating a lung. The lung can be stored and transported while pumping a gas into the lung and removing another gas from the lung. The cyclical inflation and deflation of the lung can be performed at a rate enhanced or optimized for lung performance.

Methods and / or devices to deliver pulmonary therapy to treat sleep disordered breathing are disclosed.

This brain stimulation guide device for positioning a brain stimulation device that stimulates the patient's brain with an electric field or magnetic field, comprises: a face mask mounted on the patient's face; band straps for fixing the face mask to the patient's face; and a procedure device holder which is fixed to the face mask and to which a brain stimulation device having a built-in magnetic coil for generating a magnetic field is mounted, wherein the face mask covers at least portions of the patient's nose, temples, and cheekbones. The brain stimulation guide device can place a brain stimulation device, which is a procedure tool, in an accurate position and thus improve the effect of a procedure.

The patent application describes an adaptable neuromodulation device for transcranial electrical brain stimulation. The system can generate complex poly-modulated waveforms by combining multiple pulse parameters in a randomized manner across dimensions like amplitude, frequency, phase, timing, and polarity. It leverages both digital and analog modulation techniques for waveform versatility. The device features pathway optimization algorithms that tune stimulation using neural feedback data to target specific brain region shapes with greater precision. It also enables closed-loop operation for responsiveness to physiological changes. The application details the mathematical and computational foundations, spanning graph theory to generate digital twins. It highlights applications from cognitive enhancement to seizure control. Overall, the innovation promises versatility and precision in non-invasive neuromodulation through adaptable, optimized waveforms grounded in sophisticated modeling.

A system for determining a target neurostimulation device position, comprising one or more cameras 108 to capture one or more images of a subject’s body part, and a neurostimulation device 102. A computer 112 is arranged to receive the images 120 from the cameras, and determine using computer vision a 3D target neurostimulation position 118 located relative to the subject’s body part. The target position comprises a 3D translational position metric indicating an area of operation of the neurostimulation device. Also disclosed is a method for determining a position of a plurality of target positions comprising obtaining for each training subject a neurostimulation device position and an image dataset of a body part of the subject. Each dataset is formatted and provided to a network architecture including a neural network path, and a scorer. The images are scored and compared to the target device position to train and adjust weighting of the network architecture.

Systems and methods herein generally relate to prolonging viability of bodily tissue, especially an organ, by adjusting pressure as needed to maintain a constant pressure within the organ even during external pressure fluctuations due, for example, to transportation of the organ in an airplane. The systems and methods herein can include an electronic pump that pumps gas into an organ and a mechanical pressure regulator to release gas based on organ pressure.

Systems, devices, and methods for neurostimulation using a combination of implantable and external devices to treat pain are disclosed.

A high-density mapping catheter comprising a catheter shaft comprising a proximal end and a distal end, the catheter shaft defining a catheter shaft longitudinal axis extending between the proximal end and the distal end, a flexible tip portion (10) fixed adjacent to the distal end of the catheter shaft, the flexible tip portion comprising a flexible framework comprising nonconductive material forming a plurality of electrode-carrying arms (188, 190, 192, 194), wherein each of the plurality of electrode-carrying arms (188, 190, 192, 194) converges with at least one other of the plurality of electrode-carrying arms at a distal end of the flexible tip portion (10), and a plurality of microelectrodes (196) mounted on the flexible framework and forming a flexible, planar array of microelectrodes (196) adapted to conform to tissue, wherein the plurality of microelectrodes (196) are mapping electrodes, wherein the flexible framework is configured to facilitate relative movement among at least some of the plurality of microelectrodes (196) relative to other of the plurality of microelectrodes (196), and wherein the nonconductive material insulates each of the plurality of microelectrodes (196) from other of the plurality of microelectrodes (196).

Flexible high-density mapping catheter tips and flexible ablation catheter tips with onboard high-density mapping electrodes are disclosed. These tips can be used for diagnosing and treating cardiac arrhythmias. The flexible, distal tips are adapted to conform to tissue and comprise a plurality of microelectrodes mounted to permit relative movement among at least some of the microelectrodes. The flexible tip portions may comprise a flexible framework forming a flexible array of microelectrodes (for example, a planar or cylindrical array) adapted to conform to tissue and constructed at least in part from nonconductive material in some embodiments. The flexible array of microelectrodes may be formed from a plurality of rows of longitudinally-aligned microelectrodes. The flexible array may further comprise, for example, a plurality of electrode-carrying arms or electrode-carrier bands. Multiple flexible frameworks may be present on a single device. A delivery adapter having an internal compression cone is also disclosed.

Flexible high-density mapping catheter tips and flexible ablation catheter tips with onboard high-density mapping electrodes are disclosed. These tips can be used for diagnosing and treating cardiac arrhythmias. The flexible, distal tips are adapted to conform to tissue and comprise a plurality of microelectrodes mounted to permit relative movement among at least some of the microelectrodes. The flexible tip portions may comprise a flexible framework forming a flexible array of microelectrodes (for example, a planar or cylindrical array) adapted to conform to tissue and constructed at least in part from nonconductive material in some embodiments. The flexible array of microelectrodes may be formed from a plurality of rows of longitudinally-aligned microelectrodes. The flexible array may further comprise, for example, a plurality of electrode-carrying arms or electrode-carrier bands. Multiple flexible frameworks may be present on a single device. A delivery adapter having an internal compression cone is also disclosed.

A system and method for maintaining an oxygen concentration of a biological sample. The oxygen concentration can be maintained by measuring the oxygen concentration within the biological sample and adjusting a rate of an oxygen supplier in response to this measurement. For example, when the oxygen concentration is below a threshold, oxygen can be delivered to the biological sample at a higher rate.

A system and method for maintaining an oxygen concentration of a biological sample. The oxygen concentration can be maintained by measuring the oxygen concentration within the biological sample and adjusting a rate of an oxygen supplier in response to this measurement. For example, when the oxygen concentration is below a threshold, oxygen can be delivered to the biological sample at a higher rate.

The present invention relates to a movement disorder monitor, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a treatment delivery system for treating a subject in response to changes in the severity of a subject's symptoms. The present invention further provides for a system and method, which can accurately quantify symptoms of movement disorders, utilizing continuously obtained kinetic information to be analyzed, accurately distinguishing between symptoms of movement disorders and activities of daily living, relating quantified symptoms to a standard clinical rating scale, and correlating a subject's symptoms with certain physiological and environmental factors. The present invention still further provides for home monitoring of symptoms in subjects with these movement disorders in order to capture the complex fluctuation patterns of the disease over the course of days, weeks, months, or years.

Various aspects of this disclosure relate to a prosthetic cover comprising an array of sensors, which transmit signals to an array of electrodes in a liner that fits over a residual limb of an amputee. Different interactions with the prosthetic cover cause different activation of the electrodes to transmit electrical current through different areas of the residual limb and modulate neurons differently within the residual limb. Various aspects of this disclosure also relate to a prosthetic liner with a substrate that includes electrodes for transcutaneous electrical nerve stimulation and / or electronic muscle stimulation for a residual limb.

The invention discloses a brain-computer hybrid intelligent closed-loop swallowing rehabilitation system for treating dysphagia after stroke, and relates to the field of artificial intelligence medical instruments. The system is composed of a plurality of key modules: an intelligent swallowing brain-computer interface module for accurately identifying a swallowing intention through multi-modal physiological signal acquisition and processing; the intelligent swallowing functional electrical stimulation module is used for finely regulating and controlling stimulation parameters according to the condition of the patient; the AI auxiliary online integrated module is used for realizing non-invasive brain-controlled swallowing and high-precision AI regulation and control; the closed-loop intelligent feedback regulation and control module is used for real-time monitoring, early warning and self-adaptive optimization of electrical stimulation; the cloud platform remote monitoring and data storage module supports remote diagnosis and treatment of doctors; and the man-machine interaction interface display and printing module optimizes doctor-patient interaction. According to the system, a brain-computer interface and FES are combined, a personalized, safe and efficient rehabilitation scheme is provided for a patient based on data driving and an artificial intelligence algorithm, swallowing function recovery can be accelerated, complications are reduced, and the system has great clinical and social values.

The invention discloses a peripheral nerve stimulation system based on muscle fatigue prediction and compensation, which is used for acquiring electromyographic signals and predicting muscle fatigue states during nerve stimulation, and timely warning and adjusting stimulation to ensure the stability of muscle strength, and comprises a stimulation output module used for stimulating target nerves to activate target muscles according to stimulation parameters; the acquisition and analysis module is used for synchronously acquiring electromyographic signals of target muscles, preprocessing the electromyographic signals and extracting electromyographic signal features; the fatigue prediction module is used for predicting the fatigue state of the muscle according to the electromyographic signal characteristics; the compensation control module is used for adjusting stimulation parameters according to the fatigue state of the muscle and sending the stimulation parameters to the stimulation output module to ensure that the muscle strength is stable in the stimulation process; and the user interaction module is used for performing stimulation control and setting in real time and displaying the stimulation effect and the muscle fatigue state. Muscle fatigue and strength attenuation in the peripheral nerve stimulation process can be dynamically predicted and compensated in time, and the safety, accuracy and reliability of nerve stimulation are improved.

A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and / or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and / or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal. The second electrode is in communication with the first electrode through a hardwire or wireless connection.

Systems and methods herein generally relate to prolonging viability of bodily tissue, especially an organ, by adjusting pressure as needed to maintain a constant pressure within the organ even during external pressure fluctuations due, for example, to transportation of the organ in an airplane. The systems and methods herein can include an electronic pump that pumps gas into an organ and a mechanical pressure regulator to release gas based on organ pressure.

The invention discloses an intelligent orthopedic rehabilitation self-adaptive evaluation method and device based on multi-modal physiological feedback. The method comprises the steps that multi-modal physiological data including electromyographic signals, knee joint three-dimensional motion trails, plantar pressure distribution and cognitive input degree of a subject are synchronously collected; constructing a three-dimensional baseline vector according to the MMT muscle force test, knee joint ROM measurement and VAS pain score of the subject; inputting the multi-modal physiological data and the three-dimensional baseline vector into a personalized orthopedic rehabilitation model, and outputting a knee joint function index prediction value and personalized rehabilitation adjustment parameters; dynamically adjusting electrical stimulation parameters according to rehabilitation adjustment parameters output by the personalized orthopedic rehabilitation model; if the cognitive load index exceeds the early warning line, the electrical stimulation intensity is reduced; otherwise, activating the hippocampus body wave stimulation mode. Adjustment is carried out according to the real-time state of the subject, blindness and subjectivity in the rehabilitation process are avoided, and the rehabilitation efficiency and success rate are improved.

The invention discloses a cranial nerve double-path stimulation intelligent regulation and control method and system for Parkinson's disease, and relates to the technical field of medical treatment and neural engineering, and the method comprises the steps: obtaining an electroneurographic signal of a target patient based on a stimulation electrode, and determining neural activity features according to the electroneurographic signal; the stimulating electrodes comprise a first stimulating electrode and a second stimulating electrode; determining a nerve evaluation value according to the nerve activity characteristics, and generating a co-stimulation parameter based on the nerve evaluation value; initial stimulation parameters of the stimulation electrode are adjusted based on the co-stimulation parameters, the target patient is stimulated through the stimulation electrode, and cranial nerve two-way stimulation intelligent regulation and control for the Parkinson's disease are completed. According to the invention, by introducing the abnormal oscillation mode and evaluating the synchronism characteristics of the neural network in real time, the neural activities of the deep brain and the vagus nerve area are comprehensively quantified, and the accuracy of nerve regulation and control is improved; by generating collaborative stimulation parameters and comprehensively considering the mutual influence of the two stimulation pathways, intelligent collaborative regulation and control are realized.

The invention belongs to the field of cerebral apoplexy rehabilitation training, and provides a cerebral apoplexy upper limb dynamic rehabilitation method and system based on vagus nerve electrical stimulation, the excitement degree of a cortical spinal cord pathway of a patient is measured and evaluated by using motor evoked potential to obtain a motor function evaluation result, and an initial rehabilitation training task is set according to the motor function evaluation result; the training motion intention of the patient is determined by monitoring the electroencephalogram signal and the electromyographic signal of the patient, and percutaneous ear vagus nerve electrical stimulation is triggered; after percutaneous ear vagus nerve electrical stimulation, performing rehabilitation training analysis on basic clinical characteristics and multi-modal signals of the patient to determine intermuscular coordination, brain region connectivity and brain muscle coupling of the patient; the training condition of the patient is evaluated according to the rehabilitation training analysis result, and parameters of percutaneous ear vagus nerve electrical stimulation and training tasks are adjusted based on the evaluation result for iterative rehabilitation training; and stopping iteration until the rehabilitation training analysis result of the patient reaches a preset standard, and completing rehabilitation training.

Method and systems are described for identifying electrodes for stimulation of a patient using a stimulation system. The stimulation system includes at least one stimulation lead implanted in a patient and having electrodes disposed thereon. The method includes obtaining a plurality of bioelectrical signals, wherein each of the bioelectrical signals is obtained using a different one, or a different combination, of the electrodes; analyzing a dataset including the bioelectrical signals to identify at least one fundamental component of the dataset, each of the at least one fundamental component identifying a contribution of one or more of the electrodes to the fundamental component; and using at least one of the at least one fundamental component to identify one or more of the electrodes for stimulation according to the contribution of each of the one or more of the electrodes to the at least one of the at least one fundamental component.

The invention discloses a vagus nerve stimulation parameter closed-loop adjustment method and system based on electroencephalogram characteristics. The method comprises the steps that real-time electroencephalogram signals of a patient are obtained, and time domain information and frequency domain information of the electroencephalogram signals of all frequency bands in the real-time electroencephalogram signals are extracted; on the basis of the time domain information and the frequency domain information of the electroencephalogram signals of all the frequency bands, electroencephalogram signal index features are calculated, and the electroencephalogram signal index features comprise an electroencephalogram signal power spectrum, a brain dynamic symmetry feature, a brain function connection feature and a rhythm feature; determining the state type of the patient according to the electroencephalogram signal index characteristics; determining parameter configuration information of vagus nerve stimulation according to the state type of the patient; and adjusting parameters of the vagus nerve electrical stimulation equipment according to the parameter configuration information of vagus nerve stimulation. According to the invention, timely and accurate electrical stimulation can be applied to a patient, the treatment accuracy is improved, the stimulation efficiency and the treatment effect are enhanced, side effects are reduced, and more accurate and individualized treatment management is realized.

Systems, devices, and methods for electrically stimulating peripheral nerve(s) to treat various disorders are disclosed, as well as signal processing systems and methods for enhancing diagnostic and therapeutic protocols relating to the same. Personalized therapy based on algorithms and aggregated data are also provided.