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5036results about "Artificial respiration" patented technology

Systems and methods for measuring oxygen concentration for lung preservation

ActiveUS12485064B2ElectrotherapyDead animal preservationLung preservationBiochemistry
A system and method for maintaining an oxygen concentration of a biological sample. The oxygen concentration can be maintained by measuring the oxygen concentration within the biological sample and adjusting a rate of an oxygen supplier in response to this measurement. For example, when the oxygen concentration is below a threshold, oxygen can be delivered to the biological sample at a higher rate.
Owner:PARAGONIX TECHNOLOGIES INC

Closed-loop noninvasive spinal cord electrical stimulation regulation and control method and system based on motion data

The invention discloses a closed-loop noninvasive spinal cord electrical stimulation regulation and control method and system based on motion data, and the system is provided with a flexible electrode array patch which is attached to the skin surface of a to-be-tested human body; the sensing module is used for collecting electromyographic signals or acceleration signals of a user; the signals are processed, and characteristic values related to actions and motions are extracted; the closed-loop feedback module compares the characteristic value with a model set characteristic / threshold value, and judges whether to start stimulation site and stimulation parameter adjustment or not; automatically selecting an optimal electrode unit and a corresponding stimulation parameter based on a judgment result; the dynamic regulation and control module controls the optimal electrode unit to output stimulation current, and regulates the activity of corresponding spinal cord neurons; and continuously performing closed-loop adjustment on the electrode unit and the stimulation parameters according to the motion feedback data. According to the method and system, precise stimulation and closed-loop regulation and control based on the motion response of the patient are achieved, and the problems that stimulation target positioning depends on artificial experience, parameter adjustment is not timely, and individualized and closed-loop feedback capacity is lacked are solved.
Owner:SPACE ERA (BEIJING) TECH CO LTD

Transcranial stimulation control method, transcranial stimulation control system and computer readable storage medium

The invention provides a transcranial stimulation control method, a transcranial stimulation control system and a computer readable storage medium, and the method comprises the steps: collecting an electroencephalogram parameter signal, and converting the electroencephalogram parameter signal into an electroencephalogram feature vector; inputting the electroencephalogram feature vector into a large language model, obtaining an initial electrical stimulation signal corresponding to the electroencephalogram feature vector from a stimulation electroencephalogram knowledge model according to the electroencephalogram feature vector, and generating an initial electrical stimulation signal scheme; the initial electrical stimulation signal is optimized through an attention mechanism according to historical response data of a user, a final electrical stimulation signal scheme is output, and the historical response data of the user comprises a historical electrical stimulation signal scheme and user feedback information; and outputting the final electrical stimulation signal scheme to a transcranial stimulation module. The method can improve the insomnia treatment efficiency of the user.
Owner:ZHUHAI CHAOROU INTELLIGENT TECH CO LTD

Tumor electric field treatment system, electrode plate temperature detection method and electrode plate anomaly detection method

The invention provides a tumor electric field treatment system, an electrode slice temperature detection method and an electrode slice anomaly detection method, the system comprises an electrode slice and an adapter provided with a first controller, the electrode slice comprises a plurality of electrode units and a plurality of temperature detection units, the plurality of temperature detection units are divided into a plurality of row groups and a plurality of column groups, and the first controller is connected with the adapter. The grounding ends of the temperature detection units in each row group are jointly connected to the same grounding wire, and the signal ends of the temperature detection units in each column group are connected to the same dual-purpose signal wire after being in short circuit with the corresponding electrode units; when the dual-purpose signal line is connected to the temperature sampling point, the grounding wires are sequentially conducted, so that temperature detection signals detected by the temperature detection units are sampled based on the temperature sampling point; when the dual-purpose signal line is connected to the alternating power line, alternating electric signals are transmitted to the electrode units. Therefore, the temperature of the electrode plate can be detected by using fewer conductive traces, and whether the electrode plate is abnormal or not can be judged through temperature detection.
Owner:JIANGSU HEALTHY LIFE INNOVATION MEDICAL TECH CO LTD +1

Spinal epidural ventral side double-wing-shaped stimulating electrode and motion function reconstruction system

The invention belongs to the technical field of medical instruments, and particularly relates to a spinal epidural ventral side double-wing-shaped stimulation electrode and motion function reconstruction system, the spinal epidural ventral side double-wing-shaped stimulation electrode and motion function reconstruction system comprises two wing panels, each wing panel comprises a flexible substrate, the flexible substrate is provided with two bifurcated preset-curvature double-wing structures; the electrode contact array is integrated on the flexible polar plate through a bonding pad; according to the double-wing-shaped flexible substrate, through a double-wing structure with a preset curvature, after being unfolded under the driving of a nickel-titanium alloy framework, the double-wing-shaped flexible substrate accurately covers a spinal cord ventral side and double-side anterior angle motor neuron pool, and the problem that a traditional single-piece / rod-shaped electrode can only cover a back side sensing area and cannot cover a back side sensing area is solved. The ventral motor neuron group cannot be directly activated; a stimulation target spot is transferred to a ventral functional core area from a dorsal non-target area for the first time, and the anatomical suitability bottleneck of motor function reconstruction is solved.
Owner:JILIN UNIVERSITY

Tumor electric field treatment system, electrode plate temperature detection method and electrode plate anomaly detection method

PendingCN121265993ACoupling device detailsElectrical testingElectric Field TherapyAlternating current
The invention provides a tumor electric field treatment system, an electrode slice temperature detection method and an electrode slice anomaly detection method, the system comprises an alternating current signal generator, an electrode slice and a controller, the electrode slice comprises a plurality of electrode units and a plurality of temperature detection units, the plurality of temperature detection units are divided into a plurality of row groups and a plurality of column groups, and the plurality of electrode units are connected with the controller. The grounding ends of the temperature detection units in each row group are jointly connected to the same grounding wire, and the signal ends of the temperature detection units in each column group are connected to the same dual-purpose signal wire after being in short circuit with the corresponding electrode units; when the dual-purpose signal line is connected to the temperature sampling point, the grounding wires are sequentially conducted, so that temperature detection signals detected by the temperature detection units are sampled based on the temperature sampling point; when the dual-purpose signal line is connected to the alternating power line, alternating electric signals are transmitted to the electrode units. Therefore, the temperature of the electrode plate can be detected by using fewer conductive traces, and whether the electrode plate is abnormal or not can be judged through temperature detection.
Owner:JIANGSU HEALTHY LIFE INNOVATION MEDICAL TECH CO LTD +1

Tumor electric field treatment system, electrode plate temperature detection method and electrode plate anomaly detection method

The invention provides a tumor electric field treatment system, an electrode slice temperature detection method and an electrode slice anomaly detection method, the system comprises an electrode slice and an adapter provided with a first controller, the electrode slice comprises a plurality of electrode units and a plurality of temperature detection units, the plurality of temperature detection units are divided into a plurality of row groups and a plurality of column groups, and the first controller is connected with the adapter. The grounding ends of the temperature detection units in each row group are jointly connected to the same grounding wire, and the signal ends of the temperature detection units in each column group are connected to the same dual-purpose signal wire after being in short circuit with the corresponding electrode units; when the dual-purpose signal line is connected to the temperature sampling point, the grounding wires are sequentially conducted, so that temperature detection signals detected by the temperature detection units are sampled based on the temperature sampling point; when the dual-purpose signal line is connected to the alternating power line, alternating electric signals are transmitted to the electrode units. Therefore, the temperature of the electrode plate can be detected by using fewer conductive traces, and whether the electrode plate is abnormal or not can be judged through temperature detection.
Owner:JIANGSU HEALTHY LIFE INNOVATION MEDICAL TECH CO LTD +1

Adapter and tumor electric field treatment system

PendingCN121265988ACoupling device detailsElectrical testingElectric Field TherapyElectric signal
The invention provides an adapter and a tumor electric field treatment system, an electrode plate comprises a plurality of electrode units and a plurality of temperature detection units, the plurality of temperature detection units are divided into a plurality of row groups and a plurality of column groups, and the grounding ends of the temperature detection units in each row group are connected to the same grounding wire. The signal end of each temperature detection unit in each column group is in short circuit with the corresponding electrode unit and then is connected to the same dual-purpose signal line; a bidirectional change-over switch of the adapter is configured to switch a dual-purpose signal line to be connected to a temperature sampling point or an alternating power line, and when the dual-purpose signal line is connected to the temperature sampling point, each grounding line is conducted in sequence so that a temperature detection signal detected by each temperature detection unit is sampled based on the temperature sampling point; and when the dual-purpose signal line is communicated with the alternating power line, an alternating current signal is transmitted to each electrode unit through the dual-purpose signal line, so that partition control and comprehensive temperature detection of the electrode plate are realized.
Owner:JIANGSU HEALTHY LIFE INNOVATION MEDICAL TECH CO LTD +1

Tumor electric field treatment system and electrode slice temperature detection method

The invention provides a tumor electric field treatment system and an electrode slice temperature detection method, the system comprises an electrode slice and a controller, the electrode slice comprises a plurality of electrode units and a plurality of temperature detection units, the plurality of temperature detection units are divided into a plurality of row groups and a plurality of column groups, the grounding ends of the temperature detection units in each row group are jointly connected to the same grounding wire, and the signal ends of the temperature detection units in each column group are connected to the same dual-purpose signal wire after being in short circuit with the corresponding electrode units; when the dual-purpose signal line is connected to the temperature sampling point, the grounding wires are sequentially conducted, so that temperature detection signals detected by the temperature detection units are sampled based on the temperature sampling point; when the dual-purpose signal line is connected to the alternating power line, alternating electric signals are transmitted to the electrode units. In this way, a plurality of electrode units can be zoned and controlled using fewer conductive traces.
Owner:JIANGSU HEALTHY LIFE INNOVATION MEDICAL TECH CO LTD +1

Patient improvement effect analysis method for controlling spinal cord electrical stimulation through implantable brain-computer interface

The invention discloses a patient improvement effect analysis method for controlling spinal cord electrical stimulation through an implantable brain-computer interface, and relates to the technical field of medical rehabilitation, and the method comprises the steps: multi-dimensional collaborative data collection: implanting electrodes in a target brain region and below a spinal cord injury segment, installing a detection element at an exoskeleton key part, and carrying out multi-dimensional collaborative data collection; a sensor is attached to a lower limb preset muscle group, electroencephalogram signals, SCS stimulation parameters, EXS motion data and neuromuscular response data are synchronously collected, and time correlation marks are embedded; according to the method, the reliability of motion intention decoding is remarkably improved by adopting a mode of combining multi-source signal preprocessing and a multi-mode intention recognition model, and in the signal preprocessing stage, the self-adaptive filtering algorithm combining Kalman filtering and wavelet threshold denoising is applied, so that the motion intention decoding efficiency is improved. SCS electrical stimulation interference, EXS motor noise and physiological noise in the electroencephalogram signals are effectively removed.
Owner:XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI

Three-dimensional spiral high-density neural electrode and preparation method and application thereof

The invention relates to a three-dimensional spiral high-density neural electrode and a preparation method and application thereof. The three-dimensional spiral high-density neural electrode comprises a probe structure and a plurality of electrode sites. The probe structure is formed by curling a planar flexible electrode precursor, and at least one end of the probe structure is provided with a spiral outer surface of a three-dimensional spiral line structure. Electrode sites are distributed along a spiral path, have a size of 5-1000 [mu] m, and are used for contacting biological tissues. On the planar flexible electrode precursor, electrode sites are arranged on one or more straight lines forming an inclined angle alpha with the axial direction of the probe, and the spatial distribution is matched with the edge. Compared with the prior art, the method has the advantages that the constraint of a traditional wiring mode is broken through, the integration of high-density three-dimensional channels is realized under a micro size, and a new generation of solution is provided for a high-precision brain-computer interface, deep brain stimulation and a three-dimensional electroencephalogram.
Owner:NINGBO DIGITAL TWIN (EASTERN UNIV OF TECH) RES INST

Apparatus for peripheral or spinal stimulation

Provided herein are methods of treating a patient comprising providing a medical apparatus comprising an external system and an implantable system, implanting the implantable system, and delivering at least one of power or data to the implantable system with the external system. The external system comprises: at least one external antenna configured to transmit a first transmission signal to the implantable system; an external transmitter configured to drive the at least one external antenna; an external power supply; and an external controller. The implantable system comprises: at least one implantable antenna configured to receive the first transmission signal from the first external device; an implantable receiver; at least one implantable functional element configured to interface with the patient; an implantable controller; an implantable energy storage assembly; and an implantable housing surrounding at least the implantable controller and the implantable receiver. Medical apparatus are also provided.
Owner:NALU MEDICAL INC

Nerve stimulation system and parameter adjustment method thereof

ActiveCN121197674ASensorsDiagnostic recording/measuringPhysical therapyMotor evoked potentials monitoring
The invention provides a nerve stimulation system which comprises a stimulation device, the stimulation device comprises a signal generation circuit, a control module, a signal acquisition circuit and a reuse electrode, and the stimulation device is arranged to be implantable in a body, generates a stimulation signal and applies the stimulation signal to a target nerve through the reuse electrode; the signal generation circuit applies a titration stimulation signal to a target nerve according to a preset mode, the signal intensity of the titration stimulation signal in the preset mode is gradually increased to a peak value from an initial threshold value, and then the titration stimulation signal is generated after the peak value is kept for a period of time or some stimulation periods; gradually reducing to a termination threshold value and ending; when a titration stimulation signal is applied to a target nerve, the signal acquisition circuit can correspondingly acquire an evoked potential; and selecting the stimulation parameter with the lowest stimulation signal intensity in the evoked potential time period meeting the target threshold value as a parameter of a treatment stimulation signal for subsequent treatment stimulation signal application.
Owner:SINOVATION (BEIJING) MEDICAL TECHNOLOGY CO LTD

Electrode plate and tumor electric field treatment system

PendingCN121265989ACoupling device detailsElectrical testingElectric Field TherapyControl switch
The invention provides an electrode plate and a tumor electric field treatment system, the electrode plate comprises a plurality of electrode units and a plurality of temperature detection units, the plurality of temperature detection units are divided into a plurality of row groups and a plurality of column groups, and the grounding ends of the temperature detection units in each row group are connected to a grounding pin through a control switch. The signal end of each temperature detection unit in each column group is connected to a bidirectional change-over switch through a dual-purpose signal line after being respectively in short circuit with the corresponding electrode unit; when the dual-purpose signal lines are connected to the temperature sampling points, temperature detection signals detected by the corresponding temperature detection units in the corresponding column groups are respectively sampled based on the temperature sampling points by configuring the on-off states of the control switches; when the dual-purpose signal lines are connected to the alternating power lines, alternating electric signals are applied to the electrode units in the corresponding column groups based on the alternating power lines. In this way, a plurality of electrode units can be zoned and controlled using fewer conductive traces.
Owner:JIANGSU HEALTHY LIFE INNOVATION MEDICAL TECH CO LTD +1

Time interference dynamic multi-target accurate focusing transcranial electric therapeutic apparatus

The invention relates to the technical field of biomedicine, in particular to a time interference dynamic multi-target accurate focusing transcranial electric therapeutic instrument which comprises a host module, an electric stimulation module, an intelligent stimulation mode optimization coordination module, an integrated electrode module, an electroencephalogram processing module, an adaptive treatment navigation module based on fMRI + EEG and a safety protection module. The navigation module calculates fMRI and EEG information, generates and optimizes a stimulation mode, the host module overall controls all the modules, the electrical stimulation module outputs multiple paths of high-frequency interference signals and low-frequency compensation signals, the integrated electrode module achieves stimulation and electroencephalogram collection in a time-sharing mode, the electroencephalogram processing module collects and processes the signals, and the safety protection module guarantees treatment safety. According to the application, the bottleneck that the current utilization rate is low, the positioning is fuzzy and the mode is rigid in the existing transcranial electrical stimulation technology is broken through, accurate synchronous / sequential stimulation of multiple deep brain regions is realized, and the accuracy, effectiveness and safety of treatment of neurological and mental diseases are improved.
Owner:HUNAN HUAYI ELECTROMAGNETIC MEDICINE RES INST CO LTD

Closed-loop electro-acupuncture therapeutic apparatus based on cardio-cerebral coupling information feedback

The invention relates to the technical field of intelligent medical instruments, and discloses a closed-loop electro-acupuncture therapeutic apparatus based on heart and brain coupling information feedback. The device comprises a forehead electroencephalogram signal acquisition module, a single-lead electrocardio acquisition module, a Bluetooth transmission module, a signal preprocessing module, an ECG and EEG feature extraction module, a dynamic coupling analysis module, an embedded XGBoost classifier and an electroacupuncture control module. According to the system, collected EEG and ECG signals are wirelessly transmitted through Bluetooth, HRV indexes and EEG frequency band power spectral density are extracted after preprocessing, and frequency domain coherence analysis is carried out to obtain heart and brain bidirectional coupling characteristics. The embedded XGBoost classifier outputs optimal electroacupuncture stimulation parameters based on the characteristics, and the electroacupuncture control module generates corresponding bidirectional pulse waves for stimulation. According to the therapeutic apparatus, closed-loop feedback control is achieved, therapeutic parameters can be dynamically optimized, the individuation and precision level is improved, and meanwhile safety is ensured through impedance monitoring and electrical isolation.
Owner:JIANGSU PROVINCIAL HOSPITAL OF TCM

Brain organism closed-loop rehabilitation system and control method thereof

The invention provides a brain organism closed-loop rehabilitation system and a control method thereof, belongs to the field of brain-computer interfaces and rehabilitation medical treatment, and is used for solving the problems of insufficient brain state perception, poor adaptability and low robustness of a brain organism rehabilitation system in related technologies. The method comprises the following steps: synchronously acquiring multi-modal physiological signals by cooperating with physiological signal monitoring, task induction and regulation and control equipment modules, removing artifacts through preprocessing and redundancy check, extracting neuroplasticity characteristics, dynamically adjusting weight decoding brain activity intentions, regulating and controlling stimulation parameters in a closed loop, and training an optimization model in combination with a multi-center federation; accurate and highly-adaptive rehabilitation regulation and control are realized, and the rehabilitation effect and the model generalization are improved.
Owner:TIANKAI SUISHI (TIANJIN) INTELLIGENT TECH CO LTD +2

Brain-heart linkage transcranial strong alternating current stimulation feedback control method and system

The invention belongs to the cross technical field of biomedical engineering and nerve regulation technology. According to the brain-heart linkage transcranial strong alternating current stimulation feedback control method and system, heart rate variability characteristics are obtained according to electroencephalogram signals, electroencephalogram signal characteristics are obtained according to the electroencephalogram signals, and a dynamic coupling index is determined according to the electroencephalogram signals and electrocardiosignals; when the heart rate variability characteristic is greater than or equal to a corresponding heart rate characteristic baseline threshold value, the electroencephalogram signal characteristic is greater than or equal to a corresponding electroencephalogram characteristic baseline threshold value, and the dynamic coupling index is greater than or equal to a set threshold value, judging that the emotional disorder is improved, and keeping the intensity of the stimulation current unchanged; otherwise, increasing the intensity of the stimulation current to a set threshold value until the emotional disorder is improved. Through combined calculation of the electroencephalogram signals and the electrocardiosignals, dynamic monitoring and accurate evaluation of the process of treating the emotional disorder through transcranial strong alternating current stimulation are achieved, and the accuracy of electrical stimulation is guaranteed.
Owner:SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI

Adjustable auricular nerve stimulation devices, and associated systems and methods

Adjustable auricular nerve stimulation devices, and associated systems and methods, are disclosed herein. A representative device for delivering an electrical signal to a subject includes a signal delivery element including at least two electrodes configured to deliver the electrical signal to a first portion of the subject's ear. The device also includes a retention element configured to engage a second portion of the subject's ear. The device further includes an adjustment mechanism permitting movement of the signal delivery element relative to the retention element to place the at least two electrodes in contact with the first portion of the subject's ear.
Owner:NEXTSENSE INC

Intelligent ear vagus nerve regulation and control glasses and control method, control device and regulation and control system thereof

The embodiment of the invention relates to the field of intelligent wearable equipment, in particular to intelligent ear vagus nerve regulation and control glasses and a control method, control device and regulation and control system thereof, and the method comprises the following steps: acquiring pupil dynamic characteristic parameters monitored by the intelligent ear vagus nerve regulation and control glasses; calling a trained machine learning model to analyze real-time physiological state information according to the pupil dynamic characteristic parameters; according to the real-time physiological state information obtained through analysis, generating an electrical stimulation control instruction corresponding to the real-time physiological state information; and controlling an ear vagus electrode in the intelligent ear vagus nerve regulation and control glasses to implement nerve regulation based on the electrical stimulation control instruction. According to the method, the limitation of fixed parameter output of a traditional ear vagus nerve stimulation device can be broken through, the individualization and accuracy of an ear vagus nerve stimulation scheme are improved, and the problem that the treatment effect is insufficient or discomfort is caused is solved.
Owner:XUZHOU MEDICAL UNIVERSITY

Epidural electrical stimulation lower limb rehabilitation system and method based on brain-computer interface

The invention relates to the technical field of rehabilitation medical treatment and neural engineering, and particularly discloses an epidural electrical stimulation lower limb rehabilitation system and method based on a brain-computer interface, the epidural electrical stimulation lower limb rehabilitation system comprises a weight reduction suspension device, an epidural electrical stimulation module and a brain-computer interface module, the epidural electrical stimulation module controls left and right electrical stimulation through a program controller, and the brain-computer interface module comprises a wireless electroencephalogram acquisition device and an interaction terminal and is used for acquiring electroencephalogram signals of a movement area of a patient and presenting a virtual gait scene and voice prompt at a computer end. The method comprises the steps of electroencephalogram signal collection and feature extraction, motion intention judgment, stimulation control and feedback backtracking, and by combining a motion intention decoding result with electrical stimulation output, activation of a lower limb target muscle group is achieved, a training closed loop is constructed, and the method is used for postoperative rehabilitation of a spinal cord injury patient.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV

Percutaneous microflow acupuncture system closed-loop regulation and control method and system based on multi-channel acupuncture point impedance

The invention relates to the field of medical instruments, in particular to a percutaneous microflow acupuncture system closed-loop regulation and control method and system based on multi-channel acupoint impedance, and the method comprises the steps: obtaining a first surface electromyogram signal in a human body action period, and constructing a relation between an action behavior and surface electromyogram; determining a multi-channel implementation path of the percutaneous microflow acupuncture system according to the relationship; impedance characteristics of acupuncture points along the multi-channel implementation path are obtained, and percutaneous microflow electrical stimulation operation is set according to the impedance characteristics; acquiring a second surface electromyogram signal during the implementation of the electrical stimulation operation, and adjusting the electrical stimulation operation according to the first surface electromyogram signal and the second surface electromyogram signal; and acquiring a response signal for adjusting the multi-channel implementation path association region during the implementation of the electrical stimulation operation so as to change the multi-channel electrical stimulation mode. According to the invention, path calibration of multiple acupoint associated stimulation areas is implemented through multiple channels, feedback closed-loop stimulation regulation is formed by combining acupoint impedance and electromyographic signals formed during stimulation, and the stimulation efficiency is improved.
Owner:THE FIRST HOSPITAL OF HUNAN UNIV OF CHINESE MEDICINE (CLINICAL RES INST OF TRADITIONAL CHINESE MEDICINE)

Closed-loop nerve regulation and control system and method based on electroencephalogram detection

The invention provides a closed-loop nerve regulation and control system and method based on electroencephalogram detection. The defects that a traditional open-loop method lags in stimulation, equipment is heavy and the like are overcome. The system integrates an electroencephalogram acquisition module, an electroencephalogram analysis module, a remote program control module and a stimulation output module to form a closed-loop link. Through 32-channel 1kHz signal acquisition and 1-100Hz filtering pretreatment, pathological features are extracted in real time by using a deep convolutional neural network, stimulation parameters are modified through a remote program control module, and multi-channel collaborative stimulation and safe electrical stimulation are realized in combination with a time division multiplexing architecture and bipolar optocoupler isolation output. The method has the advantages that the pathological feature recognition accuracy of the deep convolutional neural network is greater than or equal to 95%, and the dynamic response delay is less than 50ms; a time division multiplexing hardware architecture is designed, multi-channel collaborative stimulation is achieved through a single DAC, and the size is reduced by 30%; + / -5V bipolar output is realized by using an optocoupler isolated H bridge driver, and the IEC 60601 medical safety standard is met; wireless regulation and control of stimulation parameters are supported, the long-term implantation requirement is met, and the risk of a secondary operation is reduced.
Owner:BEIHANG UNIV

Mouse spinal cord flexible electrode and stimulation parameter optimization method

The invention discloses a mouse spinal cord flexible electrode and a stimulation parameter optimization method, and relates to the technical field of parameter optimization. The mouse spinal cord flexible electrode comprises a soluble insertion layer, a gradient substrate layer, spinal cord anastomosis ribs, a conductive snakelike net, a hemispherical touch dot matrix, a microfluidic layer, an optical waveguide layer and a top packaging layer; the soluble insertion layer is photo-crosslinked PEG-DMA with the thickness of 5-25 m, the Young modulus is kept within the range of 0.8-1.5 GPa before implantation, and the soluble insertion layer is hydrolyzed in cerebrospinal fluid within 0.5-3 hours after implantation and completely falls off; the spinal cord anastomosis rib comprises an expandable S-shaped folding structure arranged on the upper surface of the gradient substrate layer, the distance between every two adjacent ribs ranges from 80 m to 200 m, the height of the folded state is not larger than 15 m, the height of the unfolded state ranges from 15 m to 40 m, and the spinal cord anastomosis rib is used for forming a cerebro-spinalfluid bypass groove extending in the longitudinal direction of the spinal cord on the surface of the dura mater. According to the invention, the positioning precision, safety and long-term efficiency of mouse spinal cord electrical stimulation can be effectively improved.
Owner:THE FIRST AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE

Electrode parameter determination method for brain deep electrical stimulation and related equipment

The invention provides a brain deep electrical stimulation electrode parameter determination method and related equipment, and the method comprises the steps: building a head simulation model which comprises conductivity distribution; determining one or more target stimulation target spots and one or more non-target inhibition areas on the head simulation model; based on one or more target stimulation target spots and one or more non-target inhibition areas, multiple groups of electrode configuration schemes are determined through an electrode positioning method, each group of electrode configuration scheme is configured on the head simulation model, and multiple groups of stimulation simulation models are obtained; performing finite element solution based on the anatomical structure and the conductivity distribution of each group of stimulation simulation models, and optimizing the electric field intensity of one or more target stimulation target spots and the electric field intensity of one or more non-target suppression regions to obtain a plurality of electrode parameters; and determining a target electrode parameter in the plurality of electrode parameters, and taking an electrode configuration scheme corresponding to the target electrode parameter as a target electrode configuration scheme.
Owner:SHENZHEN SHENYI TECHNOLOGY CO LTD

Electrical stimulation parameter determination method and device, equipment, medium and medical system

The embodiment of the invention discloses an electrical stimulation parameter determination method, device and equipment, a medium and a medical system. The method comprises the following steps: acquiring a brain three-dimensional model corresponding to a target user of which the brain is implanted with at least one stimulation electrode; determining at least one electrode contact combination corresponding to the target nucleus simulation model according to the first spatial position information of the target nucleus simulation model and the second spatial position information of the electrode simulation model; determining at least one group of candidate electrical stimulation parameters of the electrode contact combination according to the electrode contact combination and a target nucleus simulation model; determining the total power consumption of the stimulator of the candidate electrical stimulation parameters according to a preset total power consumption quantitative model of the stimulator and the candidate electrical stimulation parameters; and determining at least one group of target recommended electrical stimulation parameters from the plurality of groups of candidate electrical stimulation parameters according to the total power consumption of the plurality of stimulators. According to the technical scheme, the effect of accurately screening the recommended electrical stimulation parameters with low energy consumption and efficient stimulation effect according to the electrical stimulation power consumption is achieved.
Owner:SCENERAY

Method for generating personalized nerve regulation and control stimulation scheme

The invention provides a method for generating a personalized nerve regulation and control stimulation scheme, and aims to generate a precise nerve regulation and control stimulation scheme for an individual through an electroencephalogram evaluation result. The method comprises the following steps: firstly, constructing a scheme library containing a plurality of transcranial electrical stimulation basic schemes; secondly, collecting resting-state electroencephalogram signals of a user, extracting electroencephalogram characteristic indexes related to emotion, cognition and sleep, and comparing the electroencephalogram characteristic indexes with a norm database to judge cognition risks; generating a primary stimulation scheme according to an evaluation result, and if a cognitive risk exists, further detecting that a feature index is abnormal and generating a targeted correction scheme; all the schemes are subjected to priority ranking, and the sequence is determined according to the abnormal severity degree and the clinical weight; and finally, outputting a personalized treatment scheme sequence of one week. According to the method, the accuracy and effectiveness of treatment are improved, high individuation, systematicness, practicability and dynamic optimization potential are achieved, and powerful support is provided for nerve regulation and control treatment.
Owner:BEIJING SONGGUO BRAIN MACHINE TECHNOLOGY CO LTD

Targeted physiotherapy and biological feedback combined intelligent self-adaptive lumbar vertebra rehabilitation brace

The invention belongs to a lumbar vertebra brace, and particularly relates to an intelligent self-adaptive lumbar vertebra rehabilitation brace combining targeted physiotherapy and biological feedback, which comprises a shell consisting of a front piece, side wings and a rear piece, the treatment module is arranged in the through hole area of the front piece and integrates a vibration actuating array, a flexible warming piece and a TENS electrode; the sensor module is provided with an overall detachable patch, and the sensor module integrates an interface pressure array, an IMU, an sEMG, an NTC and a PPT micro probe; the multi-cavity air bags are arranged along transition areas of the side wings and the front piece in a partitioned mode, and the micropump and the electromagnetic valve are connected with the multi-cavity air bags. One end of the self-adaptive winding adjusting module is arranged on the rear piece, the other end of the self-adaptive winding adjusting module is located in a winding cavity of the side wing and connected through a pull rope, the side wing end can be wound and stretched to adjust the tightness degree, vibration, heat and TENS parameter self-adaption are carried out on a pain point through PPT and sEMG feedback, lumbago can be reduced in a short time, and the curative effect can be quantified through PPT and myoelectricity.
Owner:CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE

Subskull epidural micro-invasive flexible brain-computer interface electrode

The invention is applicable to the technical field of medical instruments, and provides a subskull epidural micro-invasive flexible brain-computer interface electrode, which comprises a plurality of electrode branches, each electrode branch comprises a linear flexible main body, and the flexible main body comprises a micro power supply circuit and a signal circuit which are solidified. A plurality of electrode units are arranged on the micro power supply circuit and the signal circuit at intervals, and the electrode units are electrically connected with the micro power supply circuit and the signal circuit. The brain-computer interface electrode is in a flexible line type, can be implanted into the middle artery of the meninx, does not need craniotomy, is a micro-invasive brain-computer interface, has data monitoring accuracy close to that of an invasive brain-computer interface, does not need to worry about inflammatory response, immunostimulation, biocompatibility, brain tissue damage and other adverse factors after long-term implantation, and is suitable for popularization and application. And the thrombogenic risk of a vein stent brain-computer interface does not exist.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Tumor electric field treatment system and electrode slice quality detection method

The invention provides a tumor electric field treatment system and an electrode slice quality detection method, the system comprises electrode slices, each electrode slice comprises a plurality of electrode units and a plurality of temperature detection units, the plurality of electrode units are divided into a plurality of row groups and a plurality of column groups, the grounding ends of the temperature detection units in each row group are short-circuited to the same grounding wire, and the grounding ends of the temperature detection units in each column group are short-circuited to the same grounding wire; the signal end of each temperature detection unit in each column group is in short circuit with the corresponding electrode unit and then is jointly connected to the same dual-purpose signal line. Thus, the electric field generator or the adapter can use fewer conductive traces to perform partition control on a plurality of electrode units and sampling of temperature detection signals, and can perform quality detection on the electrode slices based on the sampled temperature detection signals.
Owner:HANGZHOU HEALTHY LIFE INNOVATION MEDICAL TECHNOLOGY CO LTD +1