The present invention discloses a transcranial direct current stimulation device and a work method thereof. The device comprises a processing unit arranged in housing, the housing is provided with a simulation electrode jack, a system display screen, a system power switch, a current regulation knob and a control button, the simulation electrode jack, the system display screen, the system power switch, the current regulation knob and the control button are all connected with the processing unit, the simulation electrode jack has an anode and a cathode, the processing unit arranged in the housing is employed to control the current and the time, the electrode plugged in the simulation electrode jack is employed to treat patients, an impedance detection module is configured to monitor whether the simulation electrode is contacted with the scalp or not, and a current detection module is configured to detect whether the current is too big or not. The transcranial direct current stimulation device can measure and the impedance of a simulation brain region in real time in the electrical stimulation process, and is small in size, light in weight, easy to carry and simple to operate.