Integrated multi-mode transcranial electrical stimulation and high-intensity deep brain stimulation device

Abstract

The invention discloses an integrated multi-mode transcranial electrical stimulation and high-intensity deep brain stimulation device, and belongs to the field of neuromedical treatment, in the device, a main control module is used for receiving data sent by a serial port display screen communication module and processing and analyzing the data, and then a signal source module is driven to output a target signal; the signal source module selectively outputs a transcranial alternating current stimulation waveform, a time intervention electrical stimulation waveform, a high-current phase modulation time intervention electrical stimulation waveform, a transcranial pulse electrical stimulation waveform and a transcranial direct current stimulation waveform based on a plurality of waveform generators and digital potentiometers; and the signal amplification and constant current output module is used for amplifying the waveform voltage signal output by the signal source module, converting the waveform voltage signal into a constant current signal and outputting the constant current signal to the output module. According to the invention, the electric field intensity generated by the stimulation current at the deep brain target spot is improved, so that the deep brain region is effectively stimulated, and a more remarkable stimulation intervention effect is achieved.

Description

Technical Field

[0001] The present invention belongs to the field of neurological medicine, and in particular to an integrated multi-mode transcranial electrical stimulation and high-intensity deep brain stimulation device. Background Art

[0002] TES (transcranial electrical stimulation) is a non-invasive, economical, and well-tolerated neuromodulation technology. It stimulates specific brain areas by applying weak electric currents through electrodes to the scalp to regulate the neural activity or excitability of the cerebral cortex. TES is widely used in research and treatment in many fields, such as cognitive enhancement and treatment of mental disorders. However, traditional TES is a whole-brain stimulation with a small stimulation current, which cannot meet the needs of effective stimulation of deep brain areas in clinical treatment. Traditional TES mainly includes tACS (transcranial alternating current stimulation) and tDCS (transcranial direct current stimulation). In recent years, several new stimulation technologies have emerged, including Hi-tACS (transcranial strong alternating current stimulation), HD-tES (high-precision transcranial electrical stimulation), and TIS (time-domain interferometric electrical stimulation). Among them, Hi-tACS effectively increases the electric field intensity reaching the deep brain nuclei and has a good analgesic effect; compared with traditional TES, HD-tES has high focus and is more effective in regulating the excitability of the cortex than single-target stimulation, and is more helpful in the treatment of complex neurological diseases; TIS has high precision and high penetration and can reach deep brain areas.

[0003] Compared with tACS, Hi-tACS is modulated by multiple signals, and the current intensity acting on the brain is stronger. The stronger the intensity of transcranial electrical stimulation, the stronger the entrainment effect on endogenous neural oscillations. Doubling the intensity of transcranial alternating current stimulation will double the field strength in the brain. High-intensity alternating current can directly stimulate deep brain areas and improve the effect. Therefore, Hi-tACS is more effective, and studies have shown that Hi-tACS involves less somatosensory sensations and known adverse reactions. In terms of strong transcranial currents, TIS also requires a larger stimulation current to have the same level of influence on neural activity as tACS, and the choice of stimulation intensity should take into account the tolerance of the subjects.

[0004] At present, the transcranial electrical stimulation instruments on the market only have traditional transcranial alternating current stimulation, transcranial direct current stimulation or time interference electrical stimulation functions, and these stimulation functions all output low-current signals. The stimulation current will be greatly reduced due to the shunting effect of tissues such as the scalp and skull of the human brain, resulting in the electric field intensity generated at the stimulation target being greatly weakened, making it impossible to effectively stimulate the deep brain areas and intervene in treatment. Summary of the invention

[0005] In order to solve the above technical problems, the present invention provides an integrated multi-mode transcranial electrical stimulation and high-intensity deep brain stimulation device, which strengthens the output current intensity of transcranial electrical stimulation without increasing the pain, thereby stimulating the deep brain and improving the stimulation effect, and integrates low-current stimulation technology and high-current stimulation technology into a set of equipment to achieve multi-functional stimulation.

[0006] To achieve the above object, the present invention adopts the following technical solutions:

[0007] A transcranial electrical stimulation device, comprising a power module, a main control module, a serial port display screen communication module, a signal source module, a signal amplification and constant current output module, a current / voltage detection module and an output module, wherein the power module, the serial port display screen communication module, the signal source module, the signal amplification and constant current output module, and the current / voltage detection module are all connected to the main control module, and the output end of the output module serves as the output interface of the device;

[0008] The signal source module includes a first voltage-dividing circuit, a multiplexer U5, a digital potentiometer M1, DDS waveform generators U4 and U6, the input end of the first voltage-dividing circuit is connected to the output end of the power module, the output end of the voltage-dividing circuit is connected to the input end of the multiplexer U5, the communication input ends of the DDS waveform generators U4 and U6 are connected to the pins of the microcontroller U3 of the main control module, the output end of the DDS waveform generator U4 is connected to the filter circuit, and the output end of the DDS waveform generator U6 is connected to the data input end of the digital potentiometer M1;

[0009] The current / voltage detection module includes a current sampling circuit, a second voltage divider circuit, a voltage follower circuit, a multiplexer U2 and an A / D converter U1, wherein the input end of the current sampling circuit is connected to the output end of the constant current output module through a sampling resistor, the output end of the current sampling circuit is connected to the input end of the A / D converter U1, the input end of the second voltage divider circuit is connected to the input end of the constant current output module, the output end of the second voltage divider circuit is connected to the input end of the voltage follower circuit, a part of the output end of the voltage follower circuit is directly connected to the input end of the A / D converter U1, and the other part is connected to the input end of the multiplexer U2, and the output end of the multiplexer U2 is connected to the input end of the A / D converter U1; the output module P3 is the connection port between the transcranial electrical stimulation device and the electrode.

[0010] As a further optimized technical solution, the signal source module also includes a crystal oscillator circuit, a multiplexer U5, and a digital potentiometer M1. The voltage divider circuit is used to divide the 3.3V voltage to obtain a 1.1V voltage. Due to the subsequent transcranial direct current stimulation waveform output, the DDS waveform generators U4 and U6 are connected to an external crystal oscillator circuit, and the frequency of the crystal oscillator is 25MHZ. The waveform generator U6 combines with the digital potentiometer M1 to output waveforms of different amplitudes, and the main control module controls it to output waveforms of different frequencies. The digital potentiometer M1 is controlled by the main control module to control the resistance value of its output part, thereby controlling the size of the signal. The input end of the multiplexer U5 is connected to the output end of the waveform generator U6 and the voltage divider circuit, and its output end is connected to the input end of the digital potentiometer M1. The control pin of the multiplexer U5 is connected to the interfaces 40 and 41 of the microcontroller U3, which is used to control the selection of the output waveform mode.

[0011] As a further optimized technical solution, in the signal source module, the DDS waveform generator U4 model is AD9959, the DDS waveform generator U6 model is AD9833, the multiplexer U5 model is MUX36D04, the crystal oscillator circuit model is XTAL_4, and the digital potentiometer M1 model is MCP41010.

[0012] As a further optimized technical solution, the signal amplification and constant current output module includes precision operational amplifiers O2, OP1, OP2, OP4, and OP5. The input end of each signal amplification circuit is connected to the output end of the signal source module, and the output end of each signal amplification circuit is connected to the input end of the constant current output circuit. The output end of the constant current output circuit, that is, pin 10 of O2, OP1, OP2, OP4, and OP5 is connected to the output module of the device, and the output end of the output module serves as the output interface of the device.

[0013] As a further optimized technical solution, the models of operational amplifiers O2, OP1, OP2, OP4, and OP5 are all OPA4197DR, and the constant current output circuit of the signal amplification and constant current output module is a Howland current source circuit.

[0014] As a further optimized technical solution, the main control module includes a microcontroller U3, a reset circuit, a download circuit and a crystal oscillator circuit. The model of the microcontroller U3 is STM32F103RCT6. Interfaces 1, 13, 19, 32, 48, and 64 of the microcontroller U3 are connected to a +3.3V voltage, interfaces 5 and 6 are connected to the crystal oscillator circuit, interface 7 is connected to the reset circuit, interfaces 8, 9, 10, and 11 are connected to the signal source chip U4, interfaces 12, 31, 47, and 63 are connected to ground, interfaces 15, 16, and 17 are connected to the pins of the signal source chip U4, interfaces 20, 21, 22, and 23 are connected to the data pins of the signal source chip U4, interface 25 is connected to the input end of the power switch KG1 for battery power detection, interface 26 is connected to the enable pin of the power switch KG1 for controlling the switch of KG1, and interfaces 29 and 30 are connected to the serial port display interface for communicating with The display screen communicates, interfaces 33-37 are connected to the pins of the A / D converter U1 for SPI serial communication, interfaces 38 and 39 are connected to the control pins of the multiplexer U2, interfaces 40 and 41 are connected to the control pins of the multiplexer U5 for controlling the connection of the specified line, interface 42 is connected to the external power-off control pin of the signal source chip U4, interface 43 is connected to the reset pin of the signal source chip U4, interface 45 is connected to the clock pin of the signal source chip U6, interface 46 is connected to the data pin of the download circuit, interface 49 is connected to the clock pin of the download circuit, interface 51 is connected to the data pin of the digital potentiometer M1, interface 52 is connected to the clock pin of the digital potentiometer M1, interface 57 is connected to the data pin of the signal source chip U6, interface 58 is connected to the chip select pin of the signal source chip U6, and interface 59 is connected to the chip select pin of the digital potentiometer M1. Interface 60 is connected to ground through resistor R130.

[0015] As a further optimized technical solution, in the current / voltage detection module, the input end of the multiplexer U2 is connected to one signal of each waveform generator U4 and U6, and its control pin is connected to the main control module. The analog-to-digital converter U1 converts the collected voltage from an analog signal to a digital signal, and then transmits the data to the main control module through SPI communication for processing and calculation to obtain the relevant parameters of the transposed output of the transcranial electrical stimulation.

[0016] As a further optimized technical solution, the power module includes a battery interface CON1, a power switch DY1, a power switch KG1, a buck-boost DC-DC converter DY2, a linear regulator and a filter circuit, wherein the power switch DY1 model is TK-6580A-11, the power switch KG1 model is TPS22810DBVR, and the buck-boost DC-DC converter DY2 model is xl6007el, wherein the battery interface CON1 is connected to ports 1 and 2 of the power switch DY1, and then port 4 of the power switch DY1 is connected to input port 1 of the power switch KG1, and output port 6 of the power switch KG1 is connected to input port 2 of the buck-boost DC-DC converter DY2, thereby boosting the voltage to obtain +18 V voltage and step down to get -18V voltage, at the same time, port 6 of the power switch DY1 is also connected to the input end of the linear regulator Vo2 to get 5V voltage, the output end of the linear regulator Vo2 is connected to the input end of the linear regulator Vo1 and the linear regulator Vo3 to get 3.3V and 1.8V voltages respectively, and the output ends of the above step-up and step-down DC-DC converter DY2 and the linear regulators Vo1, Vo2, Vo3 are all connected in parallel with the capacitor. When the power switch DY1 is pressed, the battery supplies power to the subsequent circuit, wherein the enable pin of the power switch KG1 is connected to the main control module, and the power switch KG1 is controlled to be turned on and off through the serial port of the main control module. When it is detected that the voltage in the circuit exceeds the normal range, the power switch KG1 is controlled to be turned off.

[0017] As a further optimized technical solution, the transcranial electrical stimulation device also includes a charging module and a battery power detection module. The power module uses a battery. The input end of the charging module is connected to a USB charging interface, and the output end is connected to the power module. The input end of the battery power detection module is connected to the power module, and the output end is connected to the main control module. When the power module is out of power, the main control module controls the use of the charging module to charge the power module.

[0018] As a further optimized technical solution, the charging module includes a USB interface DY-typec1 and a dual-cell lithium battery asynchronous boost charging controller CHARGE1. The USB interface DY-typec1 is directly connected to the input end of CHARGE1 in the circuit, and the output end of the dual-cell lithium battery asynchronous boost charging controller CHARGE1 is connected to the battery interface CON1.

[0019] The beneficial effects of the present invention are:

[0020] The transcranial electrical stimulation device of the present invention integrates multiple modes such as traditional transcranial direct current stimulation, transcranial alternating current stimulation and time interference electrical stimulation, and innovatively introduces high current phase modulation tACS and high current phase modulation TIS electrical stimulation functions, integrating high current and low current stimulation technologies into a single system, which can not only enhance the electric field strength in deep brain areas to improve the therapeutic effect, but also effectively reduce costs.

[0021] The device of the present invention has four output channels. The main control chip controls the output voltage of the signal source module, and then outputs a constant current through the amplifier circuit and the voltage-controlled current source. Different transcranial electrical stimulation functions are achieved by selecting the electrodes required for different transcranial electrical stimulations and controlling the output parameters of the current. Among them, high-current phase modulation tACS and high-current phase modulation TIS both use high-frequency carriers to work. As the frequency increases, the discomfort felt by the user will decrease accordingly. Through phase modulation interference technology, the continuous stimulation and non-stimulation stages are controlled: in the continuous stimulation stage, the output current phases between the two pairs of electrodes are ensured to be consistent, so that the current superposition produces a stronger effect; and in the non-stimulation period, the current between the electrodes is adjusted to the opposite phase to offset each other. In addition, the duty cycle parameters can be flexibly set according to actual needs to further optimize the duration of continuous stimulation.

[0022] In summary, the present invention can deliver higher intensity but more accurate and effective electrical signals to the deep brain without increasing the perception of skin pain, significantly improving the efficiency of specific brain regions. At the same time, it also retains all the basic functional characteristics of other types of transcranial electrical stimulation devices. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a structural block diagram of the device for integrating multi-mode transcranial electrical stimulation and high-intensity deep brain stimulation of the present invention;

[0024] Figure 2 It is the circuit diagram of the charging module of the present invention;

[0025] Figure 3 It is a circuit diagram of a power module of the present invention;

[0026] Figure 4 It is the circuit diagram of the battery power detection module of the present invention;

[0027] Figure 5 It is the circuit diagram of the main control module of the present invention;

[0028] Figure 6 It is the circuit diagram of the signal source module of the present invention;

[0029] Figure 7 It is a communication interface circuit diagram of the serial port display screen communication module of the present invention;

[0030] Figure 8 This is the circuit diagram of the signal amplification and constant current output module of the present invention;

[0031] Fig. 9 This is a circuit diagram of a current / voltage detection module of the present invention;

[0032] Fig.10 It is the circuit diagram of the output module of the present invention. DETAILED DESCRIPTION

[0033] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0034] like Figure 1 As shown, the present invention provides an integrated multi-mode transcranial electrical stimulation and high-intensity deep brain stimulation device, including a charging module, a power module, a battery power detection module, a main control module, a serial port display communication module, a signal source module, a signal amplification and constant current output module, a current / voltage detection module (i.e., the current / voltage module shown in the figure) and an output module. The power module uses a battery.

[0035] See also Figure 2 , is a circuit diagram of a charging module according to an embodiment of the present invention. The input end of the charging module is connected to a USB charging interface, and the output end is connected to a power module. The purpose is to use a charger to charge the battery when the battery power is low.

[0036] See also Figure 3 The power module includes a battery interface CON1, a power switch DY1, a power switch KG1, a buck-boost DC-DC converter DY2, a linear regulator and a filter circuit. In this embodiment, the power switch DY1 is TK-6580A-11, the power switch KG1 is TPS22810DBVR, and the buck-boost DC-DC converter DY2 is xl6007el.

[0037] The battery interface CON1 is connected to ports 1 and 2 of the power switch DY1, and then port 4 of the power switch DY1 is connected to input port 1 of the power switch KG1, and output port 6 of the power switch KG1 is connected to input port 2 of the buck-boost DC-DC converter DY2, so as to boost the voltage to obtain a +18V voltage and buck the voltage to obtain a -18V voltage. At the same time, port 6 of the power switch DY1 is also connected to the input end of the linear regulator Vo2 to obtain a 5V voltage, and the output end of the linear regulator Vo2 is connected to the input ends of the linear regulator Vo1 and the linear regulator Vo3 to obtain 3.3V and 1.8V voltages respectively, and the output ends of the above buck-boost DC-DC converter DY2 and the linear regulators Vo1, Vo2, and Vo3 are all connected in parallel with capacitors to obtain a filtering effect.

[0038] When the power switch DY1 is pressed, the battery supplies power to the subsequent circuit, wherein the enable pin of the power switch KG1 is connected to pin 26 of the microcontroller U3 of the main control module, and the power switch KG1 is turned on and off by the serial port of the microcontroller U3. When it is detected that the voltage in the circuit exceeds the normal range, the power switch KG1 is controlled to be turned off.

[0039] See also Figure 4 The input end of the battery power detection module is connected to the output port 6 of the power switch DY1, and the output end thereof is connected to the A / D function pin of the main control module.

[0040] See also Figure 5 The main control module serves as the control center of the entire transcranial electrical stimulation device, including a microcontroller U3, a reset circuit, a download circuit and a crystal oscillator circuit. The microcontroller U3 model is STM32F103RCT6. The output end of the battery power detection module is connected to the pin 25 of the microcontroller U3.

[0041] See also Figure 6 The signal source module includes a voltage divider circuit, DDS waveform generators U4 and U6, a crystal oscillator circuit, a multiplexer U5, and a digital potentiometer M1, wherein the DDS waveform generator U4 is AD9959, the DDS waveform generator U6 is AD9833, the multiplexer U5 is MUX36D04, the crystal oscillator circuit is XTAL_4, and the digital potentiometer M1 is MCP41010. The input end of the voltage divider circuit is connected to the output end of the power module, and the output end of the voltage divider circuit is connected to the DDS waveform generators U4 and U6. The output ends of the DDS waveform generators U4 and U6 are connected to the pins of the microcontroller U3 of the main control module.

[0042] See also Figure 7 , is a communication interface diagram of a serial display screen communication module. The serial display screen communication module includes a serial display screen and a communication interface.

[0043] See also Figure 8 The signal amplification and constant current output module includes precision operational amplifiers O2, OP1, OP2, OP4, and OP5, and the models of operational amplifiers O2, OP1, OP2, OP4, and OP5 are all OPA4197DR. The input end of each signal amplification circuit is connected to the output end of the signal source module, and the output end of each signal amplification circuit is connected to the input end of the constant current output circuit. The output end of the constant current output module, that is, pin 10 of O2, OP1, OP2, OP4, and OP5 is connected to the output module of the device, and the output end of the output module serves as the output interface of the device.

[0044] See also Fig. 9The current / voltage detection module includes a current sampling circuit, a voltage dividing circuit, a voltage following circuit, a multiplexing circuit and an A / D converter U1. The model of the A / D converter U1 is ADS8688.

[0045] The input end of the current sampling circuit is connected to the output end of the constant current output module through a sampling resistor, the output end of the current sampling circuit is connected to the input end of the A / D converter U1, the input end of the voltage divider circuit is connected to the input end of the constant current output module, the output end of the voltage divider circuit is connected to the input end of the voltage follower circuit, a part of the output end of the voltage follower circuit is directly connected to the input end of the A / D converter U1, and the other part is connected to the input end of the multiplexing circuit, and the output end of the multiplexing circuit is connected to the input end of the A / D converter U1; the output module P3 is the connection port between the transcranial electrical stimulation device and the electrode.

[0046] As a further optimized technical solution, the charging module includes a USB interface DY-typec1 and a dual-cell lithium battery asynchronous boost charging controller CHARGE1. The USB interface DY-typec1 can be externally connected to a charger with an output of 5V. The USB interface DY-typec1 is directly connected to the input end of CHARGE1 in the circuit, and the output end of the dual-cell lithium battery asynchronous boost charging controller CHARGE1 is connected to the battery interface CON1.

[0047] As a further optimized technical solution, the battery power detection module divides the voltage through the series-connected resistor R117 and resistor R120, the connection end of the resistor R117 and the resistor R120 is connected to the A / D pin of the microcontroller U3, the other end of the resistor R120 is connected to the ground, and the other end of the resistor R117 is connected to the output port 6 of the power switch DY1 of the power module. The microcontroller U3 detects the voltage across the resistor R120 to further obtain the battery power.

[0048] As a further optimized technical solution, the main control module includes a microcontroller U3, a reset circuit, a download circuit and a crystal oscillator circuit, wherein interfaces 1, 13, 19, 32, 48, and 64 of the microcontroller U3 are connected to a +3.3V voltage, interfaces 5 and 6 are connected to the crystal oscillator circuit, interface 7 is connected to the reset circuit, interfaces 8, 9, 10, and 11 are connected to a signal source chip U4, interfaces 12, 31, 47, and 63 are connected to ground, interfaces 15, 16, and 17 are connected to pins of the signal source chip U4, interfaces 20, 21, 22, and 23 are connected to data pins of the signal source chip U4, and interface 25 is connected The input end of the power switch KG1 is used for battery power detection. Interface 26 is connected to the enable pin of the power switch KG1 to control the switch of KG1. Interfaces 29 and 30 are connected to the serial display screen interface for communicating with the display screen. Interfaces 33-37 are connected to the pins of the A / D converter U1 for SPI serial communication. Interfaces 38 and 39 are connected to the control pins of the multiplexer U2. Interfaces 40 and 41 are connected to the control pins of the multiplexer U5 to control the connection of the specified line. Interface 42 is connected to the external power-off control pin of the signal source chip U4. Interface 43 The interface 45 is connected to the reset pin of the signal source chip U4, the interface 46 is connected to the data pin of the download circuit, the interface 49 is connected to the clock pin of the download circuit, the interface 51 is connected to the data pin of the digital potentiometer M1, the interface 52 is connected to the clock pin of the digital potentiometer M1, the interface 57 is connected to the data pin of the signal source chip U6, the interface 58 is connected to the chip select pin of the signal source chip U6, and the interface 59 is connected to the chip select pin of the digital potentiometer M1. The interface 60 is connected to the ground through the resistor R130.

[0049] As a further optimized technical solution, the serial port display screen communication module includes a serial port touch display screen and a communication interface. By setting numerical values ​​on the display screen, they are transmitted to the microcontroller U3 for processing. At the same time, the current and voltage values ​​obtained by the microcontroller U3 are transmitted to the display screen through the serial port.

[0050] As a further optimized technical solution, the signal source module includes a voltage divider circuit, DDS waveform generators U4 and U6, a crystal oscillator circuit, a multiplexer U5, and a digital potentiometer M1. The voltage divider circuit is used to divide the 3.3V voltage to obtain a 1.1V voltage. Due to the subsequent transcranial direct current stimulation waveform output, the DDS waveform generators U4 and U6 are connected to an external crystal oscillator, and the frequency of the crystal oscillator is 25MHZ. Among them, the waveform generator U4 adopts advanced DDS technology to provide high performance at low power consumption. The chip integrates four high-speed 10-bit DACs with excellent broadband and narrowband SFDR performance. Each channel has a dedicated 32-bit frequency tuning word, 14-bit phase offset and 10-bit output proportional multiplier. The microcontroller U3 can communicate with the waveform generator U4 through SPI to control the frequency, amplitude and phase of its output waveform. The main purpose of using this waveform generator this time is to output traditional transcranial alternating current stimulation waveforms, strong and effective transcranial alternating current stimulation waveforms and strong and effective time intervention electrical stimulation waveforms. The waveform generator U6 needs to combine with the digital potentiometer M1 to output waveforms of different amplitudes. It needs to communicate with the microcontroller U3 through SPI to control the waveforms of different frequencies. The main purpose of using this waveform generator is to output the transcranial pulse electrical stimulation waveform. The digital potentiometer M1 controls the resistance value of its output part by the microcontroller U3 to control the size of the signal. The input end of the multiplexer U5 is connected to the output end of the waveform generator U6 and the voltage divider circuit, and its output end is connected to the input end of the digital potentiometer M1. The control pin of the multiplexer U5 is connected to the interfaces 40 and 41 of the microcontroller U3 to control the selection of the output waveform mode.

[0051] Furthermore, the model of the DDS waveform generator U4 is AD9959, the model of the DDS waveform generator U6 is AD9833, the model of the multiplexer U5 is MUX36D04, the model of the crystal oscillator circuit is XTAL_4, and the model of the digital potentiometer M1 is MCP41010.

[0052] As a further optimized technical solution, the signal amplification module and the constant current output module are composed of four operational amplifiers OP1, OP2, OP4, OP5, O2 and their surrounding circuits. The input end of each operational amplifier is connected to the output end of the signal source module, and the output end of each operational amplifier is connected to the input end of the constant current output module. The output end of the constant current output module, that is, pin 10 of O2, OP1, OP2, OP4, OP5, serves as the output interface of the device. The four output ends of the waveform generator U4 are connected to the input end of the signal amplification module after filtering, the output end of the digital potentiometer M1 is connected to the input end of the signal amplification module, the output end of the signal amplification module is connected to the input end of the constant current output module, the constant current output module is a Howland current source circuit, and the output end of the constant current output module is connected to the stimulation electrode to output a constant current signal.

[0053] Furthermore, the operational amplifiers O2, OP1, OP2, OP4, and OP5 are all of model OPA4197DR.

[0054] As a further optimized technical solution, the current / voltage detection module includes a current sampling circuit, a voltage divider circuit, a voltage follower circuit, a multiplexer U2 and an A / D conversion circuit, wherein the input end of the current sampling circuit is connected to the output end of the constant current output module, and the current magnitude of the output signal is calculated by detecting the voltage across the sampling resistor. The voltage divider circuit, since the analog-to-digital converter U1 in the A / D conversion circuit has an input voltage range requirement, the voltage divider circuit is required to obtain a voltage that meets the sampling requirements by dividing the voltage to be sampled, wherein the voltage follower circuit plays the role of impedance conversion before the signal is converted into analog-to-digital. The input end of the multiplexer U2 is connected to one signal of each waveform generator U4 and U6, and its control pin is connected to the interfaces 38 and 39 of the microcontroller U3. Since its output signal is selected to control, the output end of the multiplexer U2 is connected to the input end of the analog-to-digital converter U1, wherein the A / D conversion circuit is composed of the analog-to-digital converter U1 and its surrounding circuits. The analog-to-digital converter U1 has a bipolar input range and 8 channels. It converts the collected voltage from an analog signal to a digital signal, and then transmits the data to the microcontroller U3 through SPI communication for processing and calculation to obtain the relevant parameters of the transposed output of the transcranial electrical stimulation, such as current, voltage and impedance.

[0055] As a further optimized technical solution, Fig.10 As shown, the output module is the output interface of the transcranial electrical stimulation device, and the output interface is connected to the input end of the constant current output module.

[0056] The specific embodiments described above further illustrate the objectives, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. An integrated multi-modal transcranial electrical stimulation and high-intensity deep brain stimulation device, characterized in that: It includes a power supply module, a serial display screen communication module, a signal source module, a current / voltage detection module, which are respectively connected to the main control module, and a signal amplification and constant current output module connected between the signal source module and the current / voltage detection module. The output module is the final output interface of the entire device and is connected to the signal amplification and constant current output module; wherein, The main control module is used to receive, process and analyze the data sent by the serial display screen communication module, and then drive the signal source module to output the target signal, and process the data monitored by the current / voltage detection module and then send it to the serial display screen communication module; The power supply module is used to supply power to each module of the device; The signal source module selectively outputs a transcranial alternating current stimulation waveform, a time intervention stimulation waveform, a high current phase modulation time intervention stimulation waveform, a transcranial pulse stimulation waveform and a transcranial direct current stimulation waveform based on a plurality of waveform generators and digital potentiometers; The input end of the current / voltage detection module is connected to the output end of the signal amplification and constant current output module, and the voltage across the current sampling resistor is measured and then the final output current of the device is calculated by Ohm's law. The output end voltage of the signal amplification and constant current output module is measured, that is, the voltage at the output interface, and the measurement data is transmitted to the main control module; The signal amplification and constant current output module is used to amplify the waveform voltage signal output by the signal source module and convert it into a constant current signal, and output it to the output module.

2. The integrated multi-modal transcranial electrical stimulation and high-intensity deep brain stimulation device according to claim 1, characterized in that: The signal source module includes a first voltage divider circuit, a multiplexer U5, a digital potentiometer M1, and DDS waveform generators U4 and U6. The input end of the first voltage divider circuit is connected to the output end of the power module. The output end of the first voltage divider circuit is connected to the multiplexer U5 as a signal source of the transcranial direct current stimulation waveform. The communication input ends of the DDS waveform generators U4 and U6 are connected to the microcontroller U3 of the main control module, and the output end of the DDS waveform generator U6 is connected to the data input end of the digital potentiometer M1; wherein the microcontroller U3 performs SPI communication with the waveform generator U4 to control the waveform generator U4 to output the transcranial alternating current stimulation waveform, the time intervention electrical stimulation waveform, and the high current phase modulation time intervention electrical stimulation waveform; the microcontroller U3 performs SPI communication with the waveform generator U6 to control the waveform generator U6 to output the transcranial pulse electrical stimulation waveform; the microcontroller U3 communicates with the digital potentiometer M1 to control the amplitude of the transcranial pulse electrical stimulation waveform and the transcranial direct current stimulation waveform.

3. The integrated multi-modal transcranial electrical stimulation and high-intensity deep brain stimulation device according to claim 2, characterized in that: The current / voltage detection module includes a current sampling circuit, a second voltage divider circuit, a voltage follower circuit, a multiplexer U2 and an A / D converter U1, wherein the input end of the current sampling circuit is connected to the output end of the signal amplification and constant current output module through a sampling resistor, the output end of the current sampling circuit is connected to the input end of the A / D converter U1, the input end of the second voltage divider circuit is connected to the output end of the signal amplification and constant current output module, the output end of the second voltage divider circuit is connected to the input end of the voltage follower circuit, a part of the output end of the voltage follower circuit is directly connected to the input end of the A / D converter U1, and the other part is connected to the input end of the multiplexer U2, and the output end of the multiplexer U2 is connected to the input end of the A / D converter U1; the output module P3 is the final output end of the entire device, that is, the connection port between the transcranial electrical stimulation device and the electrode.

4. The integrated multi-modal transcranial electrical stimulation and high-intensity deep brain stimulation device according to claim 3, characterized in that: In the signal source module, the model of the DDS waveform generator U4 is AD9959, the model of the DDS waveform generator U6 is AD9833, the models of the multiplexers U2 and U5 are MUX36D04, the model of the crystal oscillator circuit is XTAL_4, and the model of the digital potentiometer M1 is MCP41010.

5. The integrated multi-modal transcranial electrical stimulation and high-intensity deep brain stimulation device according to claim 1, characterized in that: The signal amplification and constant current output module includes precision operational amplifiers O2, OP1, OP2, OP4, and OP5, wherein the input end of the signal amplification circuit is connected to the output end of the signal source module, the output end of each signal amplification circuit is connected to the input end of the constant current output circuit, and the output end of the signal amplification and constant current output module is connected to the final output module of the device.

6. The integrated multi-modal transcranial electrical stimulation and high-intensity deep brain stimulation device according to claim 5, characterized in that: The operational amplifiers O2, OP1, OP2, OP4 and OP5 are all of OPA4197DR, and the constant current output circuit in the signal amplification and constant current output module is a Howland current source circuit.

7. The integrated multi-modal transcranial electrical stimulation and high-intensity deep brain stimulation device according to claim 1, characterized in that: The main control module includes a microcontroller U3, a reset circuit, a download circuit and a crystal oscillator circuit. The microcontroller U3 model is STM32F103RCT6. Interfaces 1, 13, 19, 32, 48, and 64 of the microcontroller U3 are connected to a +3.3V voltage, interfaces 5 and 6 are connected to a crystal oscillator circuit, interface 7 is connected to a reset circuit, interfaces 8, 9, 10, and 11 are connected to a signal source chip U4, interfaces 12, 31, 47, and 63 are connected to ground, interfaces 15, 16, and 17 are connected to pins of the signal source chip U4, and interfaces 20, 21, 22, and 23 are connected to data pins of the signal source chip U4. Interface 25 is connected to the input end of the power switch KG1 for battery power detection, interface 26 is connected to the enable pin of the power switch KG1 for controlling the switch of KG1, interfaces 29 and 30 are connected to the serial display interface for communicating with the display, interfaces 33-37 are connected to the pins of the A / D converter U1 for SPI serial communication, interfaces 38 and 39 are connected to the control pins of the multiplexer U2, interfaces 40 and 41 are connected to the control pins of the multiplexer U5 for controlling the connection of the specified line, interface 42 is connected to the external power-off control pin of the signal source chip U4, and interface 43 is connected to the external power-off control pin of the signal source chip U4. Interface 45 is connected to the reset pin of the signal source chip U4, interface 45 is connected to the clock pin of the signal source chip U6, interface 46 is connected to the data pin of the download circuit, interface 49 is connected to the clock pin of the download circuit, interface 51 is connected to the data pin of the digital potentiometer M1, interface 52 is connected to the clock pin of the digital potentiometer M1, interface 57 is connected to the data pin of the signal source chip U6, interface 58 is connected to the chip select pin of the signal source chip U6, interface 59 is connected to the chip select pin of the digital potentiometer M1, and interface 60 is connected to ground through resistor R130.

8. The integrated multi-modal transcranial electrical stimulation and high-intensity deep brain stimulation device according to claim 1, characterized in that: In the current / voltage detection module, the input end of the multiplexer U2 is connected to each signal of the waveform generator U4 and U6, and its control pin is connected to the main control module. The analog-to-digital converter U1 converts the collected voltage from an analog signal to a digital signal, and then transmits the data to the main control module through SPI communication for processing and calculation to obtain the relevant parameters output by the transcranial electrical stimulation device.

9. The integrated multi-modal transcranial electrical stimulation and high-intensity deep brain stimulation device according to claim 1, characterized in that: The power module includes a battery interface CON1, a power switch DY1, a power switch KG1, a buck-boost DC-DC converter DY2, a linear regulator and a filter circuit, wherein the power switch DY1 model is TK-6580A-11, the power switch KG1 model is TPS22810DBVR, and the buck-boost DC-DC converter DY2 model is xl6007el, wherein the battery interface CON1 is connected to ports 1 and 2 of the power switch DY1, and then port 4 of the power switch DY1 is connected to input port 1 of the power switch KG1, and output port 6 of the power switch KG1 is connected to input port 2 of the buck-boost DC-DC converter DY2, so as to boost the voltage to obtain a +18V voltage and reduce the voltage to obtain To -18V voltage, at the same time, port 6 of the power switch DY1 is also connected to the input end of the linear regulator Vo2 to obtain a 5V voltage, and the output end of the linear regulator Vo2 is connected to the input end of the linear regulator Vo1 and the linear regulator Vo3 to obtain 3.3V and 1.8V voltages respectively, and the output ends of the above buck-boost DC-DC converter DY2 and the linear regulators Vo1, Vo2, and Vo3 are all connected in parallel with the capacitor. When the power switch DY1 is pressed, the battery supplies power to the subsequent circuit, wherein the enable pin of the power switch KG1 is connected to the main control module, and the power switch KG1 is controlled to be turned on and off through the serial port of the main control module. When it is detected that the voltage in the circuit exceeds the normal range, the power switch KG1 is controlled to be turned off.

10. The integrated multi-modal transcranial electrical stimulation and high-intensity deep brain stimulation device according to claim 1, characterized in that: It also includes a charging module and a battery power detection module. The power module uses a battery. The input end of the charging module is connected to the USB charging interface, and the output end is connected to the power module. The input end of the battery power detection module is connected to the power module, and the output end is connected to the main control module. When the power module is out of power, the main control module controls the use of the charging module to charge the power module.

11. The integrated multi-modal transcranial electrical stimulation and high-intensity deep brain stimulation device according to claim 10, characterized in that: The charging module includes a USB interface DY-typec1 and a dual-cell lithium battery asynchronous boost charging controller CHARGE1. The USB interface DY-typec1 is directly connected to the input end of CHARGE1 in the circuit, and the output end of the dual-cell lithium battery asynchronous boost charging controller CHARGE1 is connected to the battery interface CON1.

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