287 results about "Olfaction" patented technology

Systems and methods of employing experimental tasks, neurological and physiological recording devices, and a sequenced process of data acquisition and analysis to produce measurements of pre-verbal and pre-conscious brain processes. An array of measurement devices are connected non-invasively to an individual (the subject). The subject experiences one or more external stimuli via any combination of senses, including visual, auditory, tactile, olfactory, and / or gustatory. Experimental tasks, data acquisition, analysis, and / or presentation steps are processed to ascertain the subject's pre-verbal and pre-conscious responses to the external stimuli, including attentional triggering, emotional valence and arousal, interest, engagement, and activation of higher cognitive processes such as memory, preference formation, and decision making.

The present invention includes systems and methods for monitoring endogenous compound concentration in blood by detecting markers, such as odors, upon exhalation by a patient, wherein such markers are the endogenous compound itself or result from the endogenous compound. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor endogenous compound levels in blood. The invention further includes a reporting system capable of tracking endogenous compound concentrations in blood (remote or proximate locations) and providing the necessary alerts with regard to emergent or harmful conditions in a patient.

The present invention is a method for the treatment of eating disorders by nerve tissue stimulation and infusion techniques to one or more areas of the brain affecting hunger and satiety; palatability and aversion; hedonism; reward / addiction behavior; mood; anxiety; depression, taste and smell. The invention also comprises methods for the treatment of disorders of these individual behaviors and in particular, disorders of taste and / or smell.

The present invention includes systems and methods for monitoring endogenous compound concentration in blood by detecting markers, such as odors, upon exhalation by a patient, wherein such markers are the endogenous compound itself or result from the endogenous compound. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor endogenous compound levels in blood. The invention further includes a reporting system capable of tracking endogenous compound concentrations in blood (remote or proximate locations) and providing the necessary alerts with regard to emergent or harmful conditions in a patient.

This invention describes the administration of multiple therapeutic agents with insulin in conjunction with bexarotene, ketamine, monoclonal antibodies Etanercept, IGF-1, and acetylcholine esterase inhibitors physostigmine, for treatment of Alzheimer's disease and other neurodegenerative diseases. Insulin, improves memory; also augments and amplifies the effects of the adjuvant therapeutic agents (paracrine and intracrine effects) and consequently reduces the β amyloid, its soluble precursors, prevents damage to the neuronal skeletal network (taupathy), and blocks glutamate excitotoxicity, reduces brain inflammation, prevents apoptosis, and increases the acetylcholine levels in the neurons and synapses; by using a combination of insulin, bexarotene, ketamine, Etanercept, IGF-1, and physostigmine therapeutic agents. The results are achieved by using the specially designed Iontophoresis incorporated olfactory mucosal delivery (ORE) catheter device located at the olfactory nerves, sphenoid sinus, and adjacent structures described here, to transport the large molecules of therapeutic agents to treat AD delivered to the CNS bypassing BBB from ORE.

Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and / or simulate a sensory-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and / or simulate “sensory” signals in nerves and / or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and / or to stimulate (i.e., trigger) and / or simulate a motor-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.

Methods of delivering a pharmaceutical compounds directly to the olfactory epithelium of a mammal by providing a pharmaceutical aerosol suspension comprising an aerosol and the pharmaceutical compound; aerosolizing the suspension to generate a stream of droplets, the stream having a rotational component, and, delivering the droplets directly to the olfactory epithelium, wherein at least 15% of the droplets are delivered directly to the olfactory deposition. The pharmaceutical compound may be encapsulated within a liposome nanoparticle.

The invention discloses a method and a device for detecting the freshness of fish based on olfaction visualization, which is characterized in that a computer is connected with a constant temperature control room and a scanner; a visual gas sensor array, the scanner, a reaction room and a sample room are arranged inside the constant temperature control room; detected gas diffused from a detected fish sample is in contact with the visual gas sensor array; the detected gas reacts with a porphyrins sensor, a pH indicator sensor or a solvation chromotropic dye sensor arranged in the visual gas sensor array; images before and after the reaction are collected by the scanner and input into the computer; and the freshness of the detected fish sample is determined according to the correlation between the color change of the three sensors and the variety and the concentration of the detected gas. The invention can ensure that the extraction quantity of characteristic values is reduced by determining the selection of the sensor type and the characteristic values; the synthesis course is simple, and the use quantity of the sensors is less; the gas can be fully contact with the sensors; the detection by human eyes can be utilized; and the use of the device is simple and convenient; the detection time only needs 3 to 5 minutes.

The invention relates to an embedded bionic olfaction smell recognition method and a device, for simulating the olfactory function of humans / animals, recognizing and analyzing the volatile gas having mixed multiple components. The embedded bionic olfaction smell recognition method comprises: (1) using an array sensor to test known smells as much as possible, to obtain a response mode for each smell, thereby establishing an information database of known smells; (2) processing pretreatment on the object smell information detected by the sensor array to realize drift compensation, information compression and noise filter; (3) processing post treatment on the smell information after pretreatment, to extract the characteristics of the object smell information, reduce measurement spatial dimension and extract the information relative to mode recognition; (4) classifying the smell information of the object smell via characteristics; (5) comparing the obtained characteristic classes of the object smell with the known smell characteristic information in the database to provide a recognition result. The invention can recognize different smells, to resolve the selectivity problem of prior single gas sensor. The analyzing device has wide smell map sensitive recognition range.

A computer implemented method, apparatus, and computer program product for generating olfactory cohorts. Olfactory data is received from a set of chemical sensors. The olfactory data describes a set of olfactory patterns for an air sample. The olfactory data is processed to identify attributes of particles in the air sample and generate digital olfactory data. The digital olfactory data comprises metadata describing the attributes of the particles in the air sample to form digital olfactory data. A set of olfactory cohorts is generated using the attributes in the digital olfactory data.

Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and / or simulate a sensory-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and / or simulate “sensory” signals in nerves and / or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and / or to stimulate (i.e., trigger) and / or simulate a motor-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.

The invention provides a series of Galphaq protein variants that functionally couple to sensory cell receptors such as taste GPCRs (TRs) and olfactory GPCRs (ORs) in an overly promiscuous manner. According to the invention, the functional coupling can be determined, for example, by measuring changes in intracellular IP3, or calcium. In a particular embodiment, the Galphaq protein variants can be expressed in mammalian cell lines or Xenopus oocytes, and then evaluated using calcium fluorescence imaging and electrophysiological recording.

This invention describes the administration of multiple therapeutic agents with insulin in conjunction with bexarotene, ketamine, monoclonal antibodies Etanercept, IGF-1, and acetylcholine esterase inhibitors physostigmine, for treatment of Alzheimer's disease and other neurodegenerative diseases. Insulin, improves memory; also augments and amplifies the effects of the adjuvant therapeutic agents (paracrine and intracrine effects) and consequently reduces the β amyloid, its soluble precursors, prevents damage to the neuronal skeletal network (taupathy), and blocks glutamate excitotoxicity, reduces brain inflammation, prevents apoptosis, and increases the acetylcholine levels in the neurons and synapses; by using a combination of insulin, bexarotene, ketamine, Etanercept, IGF-1, and physostigmine therapeutic agents. The results are achieved by using the specially designed Iontophoresis incorporated olfactory mucosal delivery (ORE) catheter device located at the olfactory nerves, sphenoid sinus, and adjacent structures described here, to transport the large molecules of therapeutic agents to treat AD delivered to the CNS bypassing BBB from ORE.

The present invention relates to an olfactory simulation device and its olfactory simulation testing method. Said device is formed from main machine box, computer processing portion, display portion and power supply circuit, and said method includes the following steps: a). the odor to be tested can be sucked into ring testing box by means of miniature diaphragm pump, said gas can be quickly passed through sensing membrane surface of every sensor, then discharged from outlet; b). every response produced by every gas sensor when the gas is passed through every sensor can be collected into datacollecting card, passed through A / D converter to obtain a multidimensional response signal; and c). said signal is processed by computer so as to can obtain the type of odor to be tested, integral intensity and its simple component composition, and can be displayed.

A system and method for repelling and deterring animals, and particularly deer, includes devices to trigger each of the animal's senses of taste, smell, sound, sight, and touch. When an animal's presence if sensed, each device is triggered in sequence, with the sequence capable of being changed to reinforce the repelling and deterring effect on the animal.

The invention relates to an animal smell learning and training method and the system thereof, and the invention comprises the following steps: (1) before training animals, cut water supply for a long period of time, make animals have strong desire for finding water during training; (2) put animals into training ground, when training, supply the computer control system with two kinds of gas having various odors, then discharge them randomly in turn; (3) if under one kind of odor the animal licks water, it will be given some water as reward; while if under the other kind of odor the animal licks water, it will be given electric shocks as punishment; (4) test more than one hundred of times circularly like that, if animal can distinguish these two various odors, a correct operant conditioned reflex is created, according to the animal behaviour, whether the animal has the ability of distinguishing these two kinds of odors can be determined. The invention use multi-functional PCI data acquisition card, video capture card and control software in the system, so that it is able to control and record the experiment process automatically and analyze behaviors.

The invention relates to an olfactory analog instrument and a qualitative, quantitative and simultaneous analysis method of various gases, and has the following characteristics that: firstly, the instrument comprises a test box, headspace gas generating devices, a computer and a clean air bottle; secondly, the constant temperatures of a gas sensor array workroom, a sample to be detected and a headspace volatile gas are 55+-0.1 DEG C, heating but no refrigerating is carried out in the process at constant temperature, and the volume of the headspace volatile gas is 180 milliliters; thirdly, gas headspace sampling is carried out automatically within five seconds by a micro-vacuum pump, a magnetic valve, a throttle valve, a sample injector, an automatic sample lifting device of the test box and the computer; fourthly, the hole of the sample injector is directly communicated with the air inlet hole of the gas sensor array workroom; fifthly, the qualitative, quantitative and simultaneous analysis method of various gases is realized by a structurized neural network module. The olfactory analog instrument is provided with six headspace gas generating devices capable of measuring six samples within one hour, thereby having the advantages of high automatic degree, simple and convenient operation and low test cost.

The invention provides an olfactory analog instrument and an on-site analysis method for the odor grade of a specific substance. The invention has the following characteristics: 1, a gas sensor array constant temperature operation room, a computer and an autoinjection system are integrated in a test box; 2, utilization of a sample bottle with a volume of 250 ml and 25 ml of a to-be-tested sample enables a gas-liquid ratio to be 9: 1; 3, parallel resistance wires respectively wind in a semi-circle manner to generate 45-W power, so the sample and headspace volatilized gas are heated to a temperature of 80 DEG C in only 8 min and maintained at the temperature for 30 min; 4, 25 ml of an aqueous ethanol solution with a concentration of 100 ppm is used to generate standard reference gas in the sample bottle with a volume of 250 ml, and correction on gas sensors are carried out based on the generated standard reference gas; 5, headspace sampling flow is 500 ml / min, sampling time is 30 s, and gas sensor response signals undergo lowpass filtering and dimensionality reduction pretreatment; and 6, a database is established, and the olfactory analog instrument carries out on-site detection and grade prediction and identification on the odor of specific substances consisting of an adhesive, petroleum wax, leather, glycerin and edible vegetable oil.

The invention discloses pungent traditional Chinese medicine odor fingerprint map construction system and method based on bionic olfaction. The pungent traditional Chinese medicine odor fingerprint map construction system based on bionic olfaction comprises a sensor array (2), a signal modulation module (3), a digital analog conversion circuit (4) and a computer information processing system (5), wherein the sensor array (2) is arranged on the position which can detect the odor of pungent traditional Chinese medicines, the input end of the signal modulation module (3) is connected with the output end of the sensor array (2), the output end of the signal modulation module (3) is connected with the input end of the digital analog conversion circuit (4), and the output end of the digital analog conversion circuit (4) is connected with the computer information processing system (5). The pungent traditional Chinese medicine odor fingerprint map construction system based on bionic olfaction has the advantages of simple structure, low cost and objective and reliable determination result. The pungent traditional Chinese medicine odor fingerprint map construction method based on bionic olfaction is simple and convenient.

An alarm system integrating the sense of smell (i.e., an olfactory component) as an alerting modality is described. The olfactory component is uniquely recognizable and distinguishable from traditional visual or audible alerting components and can be used to increase the number of separate alarms that a person can respond to and / or decrease the reaction time for responding to the alarms.

An olfaction processor (OLP) (100) that generates RAW data (35) including content data (139d) relating to chemical substances is provided. The OLP (100) includes a generator (130) that generates the RAW data (35). The chemical substances include at least one of compounds, molecules, and elements. The generator (130) includes a conversion unit (131) that converts intensity variations, which show detected chemical substances included in data from at least one sensor that detects an amount that changes due to presence of at least one of the chemical substances, to the content data (139d) by mapping onto a frequency space where a plurality of frequencies have been respectively assigned to a plurality of specified chemical substances.

Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and / or simulate a sensory-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and / or simulate “sensory” signals in nerves and / or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and / or to stimulate (i.e., trigger) and / or simulate a motor-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.

The invention relates to a traditional Chinese medicine material odor distinguishing method based on a simulating olfaction and a device thereof. The distinguishing method of the invention includes the following steps: 1) an odor tested object of traditional Chinese medicine material samples is prepared; 2) the odor fingerprint of the simulating olfaction method is established; 3) the odor fingerprint is standardized; 4) the odor fingerprint of the traditional Chinese medicine materials to be tested and the standard odor fingerprint are compared and a distinguishing result is obtained. The distinguishing device of the invention comprises an automatic injector, a metal oxidizing gas sensor array, a weak signal conditioning circuit, an analog-to-digital conversion circuit, a computer for information process and a monitor, wherein, the output end of the automatic injector is connected with the input end of the metal oxidizing gas sensor array; the output end of the metal oxidizing gas sensor array is connected with the input end of the weak signal conditioning circuit, the output end of the weak signal conditioning circuit is connected with the input end of the analog-to-digital conversion circuit, the output end of the analog-to-digital conversion circuit is connected with the input end of the computer for information process, and the output end is connected with the monitor. The traditional Chinese medicine material odor distinguishing method and the device thereof conform to the traditional medicine theoretical practicable method, and are convenient and practical.

An apparatus, module, methods and systems for automated, standardized assessment and analysis of a human olfactory system's odor detection ability as an indicator or predictor of cognitive impairment or change in cognitive health, and other health conditions such as diabetes. Notably, the present invention is operable for use across all age groups of humans and provides quantitative detection and analysis of a human olfactory system's detection ability compared to a relevant demographic population.

A method for automatically detecting the characteristic parameters of pulse state of the traditional Chinese medicine is based on the probability reasoning model of Bayes network. The modern signal processing technique and image recognizing technique are used to take the characteristics of tongue manifestation and pulse state for automatic analysis and judgement. After the result is integrated with the information obtained by ausculation, olfaction and interrogation, the intelligent computer-aided discrimination can be performed.

The invention discloses an intelligent judgment method for fruit freshness based on coordination of visual information and olfactory information, and belongs to the technical field of non-destructive testing of foods and agricultural products. The intelligent judgment method comprises the following steps: using a computer vision system to monitor the change of surface characteristics of a fruit; using an olfactory information imaging system to monitor the change of smell of the fruit; establishing a relationship between fruit appearance information, such as surface color and texture, and each of fruit smell characteristic information and fresh freshness at the same time; simulating a human identification method; and performing intelligent judgment on the freshness of fruits at a storage stage based on visual information, olfactory information, in particular coordination of the visual information and the olfactory information. The intelligent judgment method adopts the judgment process not destructive to a detection object, has higher detection accuracy and reliability relative to the single visual or olfactory detection method, can perform intelligent management on the fruits according to the freshness in the storage process, can effectively reduce the post-harvest loss of the fruits, and achieves agricultural income increase.

The invention discloses an aromatic essential oil drug for preventing and treating depression, boosting mood and improving brain function and its composition, which contains main pharmacological active ingredients: vanillin, vanillin salt or isomers of vanillin Any one, two or three mixtures can also be added with other natural spices and native plant essential oils such as rosewood, clove, benzoin essential oils and so on. The medicine of the present invention stimulates the olfactory nerve through the nose and the oral cavity to regulate the olfactory center of the brain and then affect different brain regions, so as to improve brain function, relieve depression, improve mood, and reduce suicide rate, and has quick onset, low concentration, no toxic side effect.

The invention discloses a method for evaluating mustard sauce flavor grades by a taste system and an electronic nose, and belongs to the technical field of condiment analysis and identification methods. The method includes the steps of acquiring intelligent sensory data of mustard sauce by an electronic tongue taste system and an electronic nose olfactory system; performing digital processing for traditional sensory evaluation indexes; analyzing relations among the acquired sensory evaluation indexes, stoichiometric indexes and the intelligent sensory data by the aid of a random forest model; evaluating sensory grades of mustard sauce flavor. According to the method, objectivity and accuracy of sensory evaluation of the mustard sauce can be effectively improved, and the method is simple to operate, low in sample consumption and cost and short in consumed time and has high popularization and application values.