2 results about "Olfactory system" patented technology

Smell loss (hyposmia) is a common cognitive deficit perceived clinically as a nasal abnormality but, in reality, it is a deficit of complex biochemical detection and processing of externally generated chemical events. A major mechanism initiating hyposmia involves abnormalities of growth of human olfactory cells through altered growth factor stimulation of stem cell activity. While several growth factors are involved well known signaling substances generate and perpetuate this process; among these substances are cAMP and cGMP. We have hypothesized a role for cAMP in taste and olfaction as a growth factor necessary for stem cell maturation. We have thus measured cAMP and cGMP in parotid saliva of 19 normal subjects and 144 patients with hyposmia to evaluate roles for these signals in cognition. Results indicate that patients secrete significantly less cAMP (0.40+ / −0.03 pmol / mg protein (Mean+ / −SEM); patients; 0.67+ / −0.09, normals, p<0.005) and significantly less cGMP (0.072+ / −0.003, patients; 0.100+ / −0.007, normals, p<0.005) than do normals. While parotid gland secretions relate directly to taste bud growth factors many substances secreted in saliva are similar to those secreted in nasal mucus. The present results indicate aberrant signaling in saliva may serve both as a marker for hyposmia and as an indicator of a mechanism which interferes with olfactory system function.

The application belongs to the technical field of gas sensing and neuromorphic sensing devices, and more particularly relates to a bionic olfactory sensor chip and a preparation method and application thereof. The bionic olfactory sensor chip comprises a gate electrode, a gate dielectric layer, a two-dimensional alpha-In2Se3 channel layer and a source electrode and a drain electrode connected thereto arranged in sequence. The polarization state of the two-dimensional alpha-In2Se3 channel layer is controlled by the gate electrode voltage, so that when the sensor is exposed to a target gas, the electrical characteristics of the sensor are generated from the relaxation type nonvolatile change associated with the gas adsorption history, thereby realizing the memory of the gas exposure event. The bionic olfactory sensor chip provided by the application can work at room temperature without heating, has the advantages of low power consumption and dynamically adjustable sensing performance, is suitable for environmental monitoring, industrial safety and embodied intelligent mobile terminals, and provides a key device for constructing an artificial olfactory system and a neuromorphic sensing platform.