The invention discloses a ground state acquisition method and device of a quantum system, equipment and a storage medium, and relates to the technical field of quantum. The method comprises the following steps: preparing an initial state of a target quantum system; performing n steps of evolution and post-processing on the target quantum system, wherein the kth step of evolution comprises evolving the kth step of input quantum state to obtain a kth step of evolution final state, and the kth step of post-processing comprises removing the influence of auxiliary quantum bits used by the kth step of evolution from the kth step of evolution final state to obtain a kth step of output quantum state; and obtaining an nth-step of output quantum state obtained through the n-step of evolution and post-processing, and obtaining a ground state of the target quantum system. According to the quantum simulation algorithm based on the non-Hermite process, the ground state of a quantum system is simulated, the effect of virtual-real evolution is achieved through real-time unitary evolution related to the Hamiltonian of the system, ground state simulation is clearly and clearly achieved theoretically, the process can be directly achieved through a quantum circuit, and the operability of the scheme is improved.