The invention discloses a cold-chain logistics storage supervisory system and method. The cold-chain logistics storage supervisory system includes a temperature monitoring module, a WMS (Warehouse Management System) management module, an order management module, an in-out stock monitoring module, a three-dimensional planning module, a processing module, an inventory management module and a locating and tracking module. The old-chain logistics storage supervisory system effectively organizes the staff, space and equipment by aid of the WMS for receiving, storing, picking and transporting goods, transporting raw materials and parts to manufacturing enterprises and conveying finished products to wholesalers, distributors and final customers. The main functions of the cold-chain logistics storage supervisory system are managing and controlling all in-out stock dynamic conditions of the warehouse and doing statistic analysis about inventory data, so decision makers can find problems timely, adopt corresponding measures to adjust the inventory structure, shorten the storage period, quicken capital turnover, and further to ensure smooth logistics in enterprise production.