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203 results about "Biochemical detection" patented technology

Biochemical detection is the science and technology of detecting biochemicals and their concentration where trace analysis is concerned this is usually done by using a quartz crystal microbalance, which measures a mass per unit area by measuring the change in frequency of a quartz crystal resonator. Another method is with nanoparticles.

Method and kit for detecting anti-IgE antibody in biological sample

The present application relates generally to the field of biochemical detection. The invention provides a method and a kit for detecting an anti-IgE antibody in a biological sample. The method for detecting the anti-IgE antibody in the biological sample comprises the following steps: (a) contacting the biological sample with an acidolysis solution to dissociate the anti-IgE antibody from IgE so as to obtain an acidolysis sample; (b) contacting the acidolysis sample with a neutralization buffer solution to terminate acidolysis so as to obtain a to-be-detected sample; and (c) determining the anti-IgE antibody in the sample to be detected. The kit for detecting the anti-IgE antibody in the biological sample comprises an acidolysis solution and a neutralization buffer solution. The problem of background IgE interference in anti-IgE antibody detection is solved to a certain extent.
Owner:UNITED POWER PHARMA TECH CO LTD +1

Sperm cell analysis and diagnosis system based on multi-modal large language model

The invention relates to a sperm cell analysis and diagnosis system based on a multi-modal large language model, which comprises a multi-modal data co-processing unit, a cross-modal semantic alignment module, a dynamic diagnosis decision engine and a self-adaptive evolution system, the four-dimensional data processing module is used for synchronously processing microscopic images, motion trail videos, biochemical detection data and four-dimensional input data of medical record texts and comprises a feature selector based on a gating attention mechanism. According to the sperm cell analysis and diagnosis system based on the multi-modal large language model, quantitative analysis of sperm movement chaos features is realized for the first time, a nonlinear dynamic evaluation standard is established, a cross-modal knowledge distillation and meta-learning migration framework is developed, a data annotation dependence bottleneck is broken through, and an interpretable clinical decision support system is constructed; dynamic updating and probabilistic suggestion of diagnosis rules are achieved, semantic analysis of single-cell multi-omics data is achieved, and molecular mechanism research results are converted into clinically available knowledge.
Owner:FUDITAI HEALTH TECHNOLOGY (SHANGHAI) CO LTD

New use of gpr18 in combination with other gene detection agents and depression detection reagent

The application belongs to the field of biochemical detection, and specifically discloses a new use of a GPR18 and other gene detection agent combination and a depression detection reagent. The application of the GPR18 expression level detection agent in the preparation of a major depressive disorder detection product. The expression amount of GPR18, PDK4, NRG1 and EPHB2 in the application actually has high diagnostic efficiency, and can be used as an independent candidate diagnostic biomarker. The accuracy of each as a screening indicator reaches 0.6 to 0.8, reaching the standard of a medium-strength screening indicator, and the accuracy of the combined expression amount indicator as a screening indicator reaches 0.779.
Owner:WUHAN CHILDRENS HOSPITAL

Heterogeneous dual-core optical fiber SPR (Surface Plasmon Resonance) microfluidic chip system for biochemical detection

The invention provides a heterogeneous dual-core optical fiber SPR (Surface Plasmon Resonance) microfluidic chip system for biochemical detection. The system is characterized by comprising a heterogeneous dual-core optical fiber 1, a dual-core optical fiber movable connector 2, a dual-core optical fiber SPR probe 3, a microfluidic chip 4, a dual-core optical fiber fan-in and fan-out device 5, a double-clad optical fiber 6, a large-core-diameter optical fiber 7, a spectrograph 8, a light source 9 and the like, wherein the double-core optical fiber 1 comprises a middle single-mode fiber core and a biased multi-mode fiber core, the end face of the single-mode fiber core is subjected to inclined grinding and plated with a gold film for exciting the surface plasma resonance effect, the end face of the multi-mode fiber core collects SPR reflected light signals through a secondary reflection inclined plane, and the double-core optical fiber SPR probe 3 is embedded into the micro-flow chip 4. The device has the advantages of high sensitivity, low loss and multi-channel detection, and can be widely applied to the fields of biochemical detection, environmental monitoring, precision medical treatment and the like.
Owner:GUILIN UNIV OF ELECTRONIC TECH

Strip withdrawing key, glucometer test paper strip withdrawing structure and glucometer

The utility model relates to the technical field of biochemical detection, and discloses a strip withdrawing key, a glucometer test paper strip withdrawing structure and a glucometer. The strip withdrawing key comprises an outer shell and a buckle body which are integrally formed, the outer shell is used for covering the containing groove of the glucometer shell in a sealing mode and is attached to the containing groove in a sliding mode, and the buckle body is used for being inserted into an inner cavity of the glucometer shell from the containing groove; a sliding groove used for being buckled to the containing groove and being in sliding fit with the containing groove is formed in the inner side of the outer shell, and the inner side of the outer shell and / or the inner side of the buckle body are / is further provided with a first clamping and assembling assembly used for providing a clamping and assembling position and a first reset clamping hook used for being in elastic reset connection with the glucometer shell. A semi-hidden design is adopted, the space of an inner cavity of a glucometer shell is fully utilized, the sliding process of the whole bar withdrawing key is smoother by adopting a double guide mode of attaching a rail groove and a surface, the assembly mode is simpler, more stable and more reliable, and the integrity is better.
Owner:COFOE MEDICAL TECH CO LTD

Intelligent control method and system for high-pressure atomization irrigation and storage medium thereof

The invention relates to an intelligent control method and system for high-pressure atomization irrigation and a storage medium of the intelligent control method and system, and aims to solve the problem that the quality is inconsistent due to the fact that traditional water and fertilizer management of high-value crops is difficult to sense the internal physiological state of the crops in real time. Randomly selecting a plurality of offering samples in each management partition for destructive sampling, and obtaining crop truth value data through physiological and biochemical detection; then, an irrigation rule base is established and dynamically updated based on the truth value data, and then variable control instructions are generated for the management partitions in combination with the real-time environment data; the invention further provides a system for implementing the method and a storage medium, accurate regulation and control starting from real demands of crop bodies are achieved, the consistency of crop quality and the resource utilization efficiency are effectively improved, and self-learning and predictive prevention and control capabilities are achieved.
Owner:NINGBO FUJIN GARDEN & IRRIGATION EQUIP CO LTD

Near-infrared spectrum characteristic wave band screening and pan-cancer grading detection system based on biomarkers and working method of near-infrared spectrum characteristic wave band screening and pan-cancer grading detection system

The invention relates to a biomarker-based near infrared spectrum characteristic wave band screening and pan cancer grading detection system and a working method thereof, and the working method comprises the following steps: a spectrum collection unit collects the near infrared spectrum of a to-be-detected plasma sample to obtain spectrum data; a spectrum abnormal value eliminating unit eliminates abnormal values; the clinical biochemical data abnormal value eliminating unit is used for eliminating abnormal values of the biochemical detection data; selecting a sample set division method and a division proportion; the spectrum pretreatment unit is used for pretreating a near infrared spectrum of a to-be-detected plasma sample; the spectral characteristic wave band screening unit screens spectral characteristic wave bands in combination with clinical biochemical indexes and near infrared spectrums, so that the accuracy of pan cancer recognition is improved; and the data analysis unit performs qualitative discriminant analysis on the near infrared spectrum data, constructs an accurate cancer primary detection model and an accurate cancer accurate detection model, preliminarily identifies cancers and finely screens esophageal squamous cell carcinoma, gastric cancer, colorectal cancer and lung cancer samples. The method has good practical application and reference value for large-scale screening of cancers.
Owner:SHANDONG UNIV

Probe cleaning device for full-automatic biochemical analyzer

The utility model belongs to the technical field of biochemical analyzers, in particular to a probe cleaning device for a full-automatic biochemical analyzer, which comprises a loading plate, supporting legs are fixed at four corners of the bottom of the loading plate, a cleaning box is mounted at the top of the loading plate, and a water distribution pipe is mounted in the cleaning box; according to the utility model, through cooperative use of the installation pipe, the through hole, the elastic sheet, the fixed block, the limiting sheet and the sleeve, rapid positioning and stable fixation of the probe are realized, so that the purpose of synchronous cleaning of the inner wall and the outer wall is achieved, and the efficiency of the cleaning process and the thoroughness of probe cleaning are significantly improved. By means of the design, the cleaning process is more efficient and convenient, and an operator can easily master the cleaning device due to the simple structure. The device is low in maintenance cost, has relatively high economic applicability, and is suitable for being popularized and applied to various biochemical analyzers. By using the device, sample pollution caused by incomplete cleaning can be effectively avoided, so that the accuracy and reliability of biochemical detection data are ensured.
Owner:HUBEI JIANLIN TECHNOLOGY CO LTD

Intestinal tumor risk assessment method based on image analysis

The invention relates to the technical field of tumor risk assessment, in particular to an intestinal tumor risk assessment method based on image analysis, and the method comprises the steps: carrying out the continuous image division and parameter collection; identifying abnormal density image blocks; identifying concerned risk image blocks; judging a response risk image block; adjusting a preset synchronization degree risk threshold value; early warning judgment is carried out, and a serious early warning report is generated. According to the method, a self-adaptive and dynamically-adjusted three-level judgment system is established through real-time collaborative analysis of multi-dimensional parameters of an enteroscope image block, firstly, a suspected focus is locked based on the texture change duration, then, the focus characteristics are verified through vascular abnormality and contrast fluctuation depth, and finally, the accuracy of the focus is improved. And finally, the risk threshold is corrected in combination with intestinal wall peristalsis and the lens shielding degree, so that the problem of low early flat tumor recognition accuracy caused by insufficient flat tumor image feature capture due to excessive dependence on intestinal environment microorganism and metabolite biochemical detection is effectively solved.
Owner:SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY (SHANDONG PROVINCIAL HOSPITAL)

POCT analyzer

The utility model discloses a POCT (Point of Care Testing) analyzer, which comprises a first functional module, a second functional module and a third functional module, the second functional module is used for carrying out dry-type immunodetection; the third function module is used for carrying out dry biochemical detection; the rack comprises a first mounting plate and a second mounting plate; the POCT analyzers are arranged in a layered manner, the first functional module and the second functional module are arranged on the second mounting plate on the upper layer, and the third functional module is arranged on the first mounting plate on the lower layer. According to the POCT analyzer, the problem that the POCT analyzer is single in function is solved, the production cost is reduced, and the analyzer is more compact in structure and smaller in size.
Owner:SHENZHEN DYMIND BIOTECH

A portable hepatitis biomarker detection kit and a method for detecting hepatitis biomarkers.

This invention belongs to the field of biochemical detection and discloses a portable hepatitis biomarker detection kit. The kit contains a hydrogel; the hydrogel is obtained by dispersing hollow manganese dioxide in water to obtain an H-MnO2 dispersion, mixing the H-MnO2 dispersion with sodium alginate solution to obtain a mixed solution, and then adding a calcium salt solution to obtain the hydrogel. The hollow manganese dioxide is obtained by etching manganese Prussian blue analog nanoparticles with sodium hydroxide. The manganese Prussian blue analog nanoparticles are prepared from potassium ferricyanide, polyvinylpyrrolidone, and manganese salts. This invention utilizes the color change of hollow manganese dioxide in relation to TMB to construct a method for detecting hepatitis biomarkers using a smartphone to capture signals. This kit reduces the detection cost of hepatitis biomarkers, does not require large instruments, and is highly portable and widely applicable, possessing great potential as a novel point-of-care testing device.
Owner:CHINA PHARM UNIV

Junction Field Effect Transistor And Related Manufacturing Method

The invention firstly comprises a junction field effect transistor (JFET), namely a SiC JFET, which is completely made of SiC. The transistor is preferably manufactured by adopting a top-down method, and the manufacturing process is suitable for large-scale production. The electrical properties of the proposed SiC JFET have been evaluated under dry conditions and in a liquid medium. The concept feasibility of the SiC JFET as a biosensor 0 is verified through pH value measurement. The sensitivity of the SiC JFET provided by the invention is up to 495 mV / ph, that is, the sensitivity is nearly 100 times higher than the theoretical Nernst limit. Therefore, the device is suitable for various in-vitro and in-vivo biochemical detection applications because the device meets performance indexes generally required in the field, such as sensitivity and chemical stability, especially long-term stability.
Owner:INSTITUT NAT POLYTECHN DE GRENOBLE +3

Multi-tube method coliform group detection device

The invention relates to the technical field of biochemical detection, and discloses a multitube method coliform group detection device, which solves the problems of long detection period, complicated operation and limited sensitivity of the existing multitube method, and comprises two X-axis linear modules, the number of the X-axis linear modules is two, the two X-axis linear modules are parallel to each other, and the X-axis linear modules are parallel to each other. A first motor and an X-axis sliding table are arranged on the X-axis linear module, a Y-axis linear module is installed on the X-axis sliding table, two Z-axis linear modules are arranged on the Y-axis linear module, a pipettor and a rotary clamping jaw are installed on the two Z-axis linear modules respectively, photoelectric limiting switches and second motors are arranged on the Z-axis linear modules, and a platform is arranged below the X-axis linear module. A pipette head frame and a detection module are fixedly mounted at the top of the platform; compared with a traditional method, the method has the advantages that manual intervention is reduced, the detection efficiency and accuracy are improved, and the method is suitable for rapid microorganism detection in the fields of water quality, food and the like.
Owner:QINGDAO JIAMING MEASUREMENT & CONTROL TECH

Cuvette

1. The name of the design product: colorimetric cup. 2. The use of the design product: for biochemical detection instrument. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.
Owner:GENOBIO PHARM CO LTD

Microfluidic chip and microfluidic device

The application provides a microfluidic chip and a microfluidic device. The microfluidic chip comprises: a substrate comprising a detection area and a non-detection area, the non-detection area being arranged around the detection area; a grounding trace and a driving power supply trace arranged in the non-detection area and respectively surrounding the detection area; a binding part arranged in the non-detection area, the grounding trace and the driving power supply trace being electrically connected to the binding part; and a breakage detection line arranged in the non-detection area, two ends of the breakage detection line being respectively electrically connected to the binding part, and the breakage detection line extending from a first end to a second end around the detection area. The impedance value between the first end and the second end is detected through the binding part, or a detection signal is input at the first end and a feedback signal is received at the second end through the binding part, so as to detect whether the microfluidic chip is broken. The microfluidic chip can realize breakage detection of the chip, so as to prevent biochemical reagents from being invalidly used and biochemical detection cost from being increased.
Owner:HKC CORP LTD

General butt joint module for production-free integrated assembly line

The invention relates to a general butt joint module for a production-free integrated assembly line, and relates to the field of medical instruments. Comprising a bottom plate, a portal frame, a test tube transfer manipulator assembly, a universal transfer trolley for butt joint of biochemical sample racks and a universal transfer trolley for butt joint of immune sample racks, a biochemical sample rack universal temporary storage position is arranged in the middle of the bottom plate; immune sample rack universal temporary storage positions are arranged on the two sides of the bottom plate; a track I and a track II are respectively arranged on two sides of the bottom plate, the universal transfer trolley for butting the biochemical sample frame is arranged on the track I in a sliding manner, and the universal transfer trolley for butting the immune sample frame is arranged on the track II in a sliding manner; the portal frame is mounted on the bottom plate, and the test tube transfer manipulator assembly is mounted on the portal frame and is used for accurately carrying samples needing biochemical detection in the immune sample frame into the biochemical sample frame. The device is exquisite in design, can effectively coordinate differences of biochemical and immune sample racks in the aspects of tracks and hole numbers, and realizes smooth connection and efficient transmission of the sample racks.
Owner:SUZHOU HYBIOME BIOMEDICAL ENG CO LTD

Constant-temperature home self-checking microfluidic detection device and application thereof

The invention provides a constant-temperature household self-checking microfluidic detection device and application thereof, and belongs to the technical field of biochemical detection.The device comprises an upper cover, a thermal reaction bottom plate and a microfluidic reaction plate, and the upper cover is provided with a sample adding hole and a sample adding hole cover used for covering the sample adding hole; a water injection hole and a water injection hole plug matched with the water injection hole are arranged at the position close to the sample adding hole; a heating bin is arranged on the thermal reaction bottom plate, the heating bin comprises a thermal reaction tank A and a thermal reaction tank B, the thermal reaction tank A and the thermal reaction tank B are used for carrying out heating reaction of the heating bag and thermal slow-release reaction of the heat release bag respectively, and a heat exchange liquid flow port is formed between the thermal reaction tank A and the thermal reaction tank B; and water or thermal reaction liquid which is added through the water injection hole and used for thermal reaction is heated by the heating bag in the thermal reaction tank A and then flows to the thermal reaction tank B through the heat exchange liquid flow port. The device can thoroughly solve the technical problem that the device can only be used by an instrument, a power supply, a circuit board or a lithium battery. The method has the advantages of short time, low cost, rapidness, simplicity, safety and reliability.
Owner:CHENGDU BAISI SAIFU BIOTECHNOLOGY CO LTD

Detection kit, system and method for light-chain monoclonal immune globulin based on fluorescence labeling

The invention belongs to the technical field of biochemical detection, and particularly relates to a detection kit, system and method for light-chain monoclonal immune globulin based on fluorescence labeling. According to the method, whether the light chain type monoclonal immune globulin exists or not and the concentration of the light chain type monoclonal immune globulin are determined by reducing and specifically marking free sulfydryl at the C tail end of a free light chain of the monoclonal immune globulin in a sample and combining electrophoresis and a fluorescence detection system. The detection rate of the light-chain monoclonal immune globulin is increased, the cost is low, the operation is simple and convenient, the method is suitable for large-scale screening and grassroots scenes, and the popularization of the light-chain monoclonal immune globulin detection technology is promoted.
Owner:GONGYI PEOPLES HOSPITAL

An intelligent control method and system for high-pressure atomizing irrigation and a storage medium thereof

The application relates to an intelligent control method and system of high-pressure atomization irrigation and a storage medium thereof, and aims to solve the problem that traditional water and fertilizer management of high-value crops cannot realize real-time sensing of internal physiological states of crops, leading to inconsistent quality. The intelligent control method divides an irrigation area into multiple management partitions, randomly selects a plurality of sacrifice samples in each management partition, destructively samples the sacrifice samples, obtains true value data of crops through physiological and biochemical detection, establishes and dynamically updates an irrigation rule library based on the true value data, generates variable control instructions for each management partition in combination with real-time environmental data, and finally controls a high-pressure atomization sprinkler irrigation system to accurately execute. The application also provides a system and a storage medium for realizing the method, realizes accurate regulation and control starting from the real demand of crops, effectively improves the consistency of crop quality and the resource utilization efficiency, and has self-learning and predictive prevention and control capabilities.
Owner:NINGBO FUJIN GARDEN & IRRIGATION EQUIP CO LTD

Multi-station mechanism for rapid detection of biological reagent

The utility model relates to the technical field of biochemical detection, and discloses a multi-station mechanism for rapid detection of biological reagents, which comprises a base, a motor I is fixedly connected in the base, a rotating shaft I is fixedly connected to the output end of the motor I, a turntable is fixedly connected to the outer wall of the rotating shaft I, a placement hole I is formed in the turntable, and a placement hole II is formed in the placement hole I; a clamping assembly is arranged on the upper surface of the rotating disc. The clamping assembly comprises a first threaded rod, the lower end of the first threaded rod is rotationally connected to the upper surface of the rotary disc, the driving assembly comprises a telescopic rod, the lower surface of an electric telescopic rod is fixedly connected to the upper surface of the base, and the output end of the electric telescopic rod is fixedly connected with a supporting rod. According to the utility model, test tubes with different specifications can be clamped and fixed through the matching of the test tube clamp and the positioning frame, a plurality of placing holes can be used for detecting at the same time, and mixed reagents can be better and uniformly mixed by the turntable to achieve better detection.
Owner:SHANDONG BOZHONG SHUJI BIOTECHNOLOGY CO LTD

Nucleic acid composition and kit for identifying rice variety rice flower No.2

The invention provides a nucleic acid composition and a kit for identifying a rice variety rice flower No.2, and relates to the technical field of biochemical detection. The nucleic acid composition comprises a specific amplification primer pair and a specific detection probe. The nucleic acid composition locks the specific SNP site of the rice, and by utilizing the synergistic effect of the primer and the double probes, the rice flowery No.2 variety and the similar variety can be accurately distinguished, and the doping can be sensitively identified. The method is suitable for a real-time fluorescent PCR platform, electrophoresis and sequencing are not needed, rapid and high-sensitivity closed tube detection is achieved, and an efficient means is provided for authenticity identification and purity analysis.
Owner:SANGON BIOTECH (SHANGHAI) CO LTD

Time sequence control method for dry biochemical analyzer, control apparatus, and storage medium

The present disclosure provides a time sequence control method for a dry biochemical analyzer, a control apparatus, and a storage medium. The method comprises: dividing one biochemical test into k time sequence control cycles each in the form of nA+B, wherein each time sequence control cycle consists of two parts: nA representing n light measurement preparation parts, and B representing one light measurement part, and multiple reagent card tests are performed in each time sequence control cycle; in a light measurement preparation part of a current time sequence control cycle, controlling a card feeding device to perform card feeding actions required for light measurement on n reagent cards in the current time sequence control cycle, and controlling a sample loading device to perform sample loading actions required for light measurement on n reagent cards in the previous time sequence control cycle; and according to a preset light measurement action required by a biochemical test method in each time sequence control cycle, controlling, in a light measurement part of each time sequence control cycle, a light measurement mechanism to perform light measurement actions on all reagent cards in a reagent card reaction device. The total test duration of multiple items or multiple reagent cards is shortened, thereby improving the test efficiency.
Owner:XIAN BIOLAB BIOTECHNOLOGY CO LTD

Sample analyzer

The utility model relates to a sample analyzer and relates to the technical field of biochemical analysis. The sample analyzer provided by the utility model comprises an optical module for performing optical detection on a sample reagent mixed solution in the cuvette. The optical module comprises a light source unit, the light source unit comprises a light source, the wavelength of light emitted by the light source can cover the wavelength required by biochemical detection, the wavelength of light emitted by the light source can cover the wavelength required by biochemical detection, and the light source comprises a plurality of light-emitting elements. The light emitted by the plurality of light-emitting elements jointly forms the light of each wavelength required by the detection unit; the sample analyzer further comprises a colorimetric assembly, and the colorimetric assembly is used for matching the sizes of front and rear light spots.
Owner:MACCURA MEDICAL INSTR CO LTD

Reagent box for fluorescence immunoassay

The utility model discloses a reagent box for fluorescence immunoassay, which belongs to the technical field of biochemical detection.The reagent box for fluorescence immunoassay comprises a box body and a box door, and the box door is hinged to the box body; a plurality of ice cavities are formed in the pulling plate, and the ice cavities are filled with ice bags; wherein a gap is formed between every two ice cavities, the gaps are used for containing reagents, the reagents are attached to the outer side walls of the ice cavities, and the pulling plate freely slides in the box body and can stretch out of the box body; wherein the ice cavity is higher than the reagent; wherein the drawing plate is a structural member made of a low heat conduction coefficient, and the ice cavity is a structural member made of a high heat conduction coefficient material. According to the utility model, the technical problem that the transportation cost of the fluorescence immunoassay reagent is too high in the short-distance transportation process can be solved.
Owner:四川国际旅行卫生保健中心(成都海关口岸门诊部)

Composite surfactant composition based on synergistic effect as well as preparation method and application thereof

The invention relates to the technical field of biochemical detection, in particular to a composite surfactant composition based on a synergistic effect and a preparation method and application of the composite surfactant composition. The composite surfactant composition comprises a Tween emulsifier, an OP emulsifier and a polyoxyethylene alkyl ether emulsifier, and the Tween emulsifier can promote mutual dissolution of the OP emulsifier and the polyoxyethylene alkyl ether emulsifier through hydrogen-bond interaction; a uniform micelle structure with a small particle size is formed, the turbidity of a system is reduced, a long-chain hydrophobic group of the polyoxyethylene alkyl ether emulsifier can enhance the anchoring capacity to chylomicron and cooperates with a hydrophilic chain segment of the OP emulsifier, so that the lipid dispersion efficiency is improved, the interference inhibition rate is larger than or equal to 60%, and the stability of the system is improved. Meanwhile, after the Tween emulsifier, the OP emulsifier and the polyoxyethylene alkyl ether emulsifier are compounded, chyle particles can be efficiently wrapped, light scattering interference is reduced, and the anti-lipid interference efficiency is improved by more than or equal to 95% compared with that of a single component, so that the effect of eliminating interference in a lipid / chyle blood sample by adopting the composition is better.
Owner:URIT MEDICAL ELECTRONICS CO LTD

Optical detection device for biochemical detection

The utility model relates to the technical field of biochemical detection, in particular to an optical detection device for biochemical detection, which is characterized in that dismounting and replacing mechanisms are arranged on the inner wall of a fixed block and the surface of a detection tube, and clamping and fixing mechanisms are arranged on the inner wall of a test tube rack and the surface of a test tube body; and convenient adjusting mechanisms are arranged in the supporting table and on the surface of the moving plate. According to the utility model, when the optical detection device is used, the test tube body can be clamped and fixed on the surface of the test tube rack according to the size of the test tube body, so that the optical detection device is prevented from inclining during detection; according to the optical detection device, the positions of the test tube rack and the test tube body can be adjusted according to the position of the detection tube when the optical detection device is used, so that the detection effect of the optical detection device is better, a user can conveniently take and place the test tube body, and the user can conveniently take down the detection tube from the surface of the fixed block when the optical detection device is used; and a user can use the device conveniently.
Owner:BEIJING LAIKE BIOTECHNOLOGY CO LTD

Integrated micro-fluidic sensing chip and biochemical detection method

The invention belongs to the technical field of biochemical detection, and particularly relates to an integrated micro-fluidic sensing chip and a biochemical detection method.The integrated micro-fluidic sensing chip adopts the design that a floating gate type organic electrochemical transistor and a micro-fluidic system are integrated, the floating gate structure prevents a reactant or a detected object from making direct contact with a polymer in a channel, the service life of the transistor is prolonged, and the reliability of the sensor is improved. The long-term stability of the sensor is improved; the system is combined with a microfluidic system, breaks through a traditional direct current detection scheme, adopts alternating current signals for detection, greatly reduces noise, improves the signal-to-noise ratio, is beneficial to increase of the detection limit, and finally realizes high-precision biochemical sensing and cell detection.
Owner:TAIYUAN UNIVERSITY OF TECHNOLOGY +1

Treatment of Memory Loss with Phosphodiesterase Inhibitors

PendingUS20260041690A1Nervous disorderBoron compound active ingredientsPhosphodiesterase inhibitorSmell loss
Smell loss (hyposmia) is a common cognitive deficit perceived clinically as a nasal abnormality but, in reality, it is a deficit of complex biochemical detection and processing of externally generated chemical events. A major mechanism initiating hyposmia involves abnormalities of growth of human olfactory cells through altered growth factor stimulation of stem cell activity. While several growth factors are involved well known signaling substances generate and perpetuate this process; among these substances are cAMP and cGMP. We have hypothesized a role for cAMP in taste and olfaction as a growth factor necessary for stem cell maturation. We have thus measured cAMP and cGMP in parotid saliva of 19 normal subjects and 144 patients with hyposmia to evaluate roles for these signals in cognition. Results indicate that patients secrete significantly less cAMP (0.40+ / −0.03 pmol / mg protein (Mean+ / −SEM); patients; 0.67+ / −0.09, normals, p<0.005) and significantly less cGMP (0.072+ / −0.003, patients; 0.100+ / −0.007, normals, p<0.005) than do normals. While parotid gland secretions relate directly to taste bud growth factors many substances secreted in saliva are similar to those secreted in nasal mucus. The present results indicate aberrant signaling in saliva may serve both as a marker for hyposmia and as an indicator of a mechanism which interferes with olfactory system function.
Owner:CYRANO THERAPEUTICS INC

A method and system for simultaneous analysis of multiple indicators of blood lipids in fingertip peripheral blood

PendingCN122081442ARealize synchronous detectionlow detectabilityMicrobiological testing/measurementColor/spectral properties measurementsVenous bloodBlood lipids
This invention discloses a method and system for simultaneous analysis of multiple lipid indicators in fingertip capillary blood, relating to the field of chemical analysis. The method includes S1: micro-sample pretreatment of fingertip blood; S1.5: sample matrix interference pretreatment; S2: multi-channel parallel specific reaction; S3: multi-band spectral synchronous detection; S4: machine learning intelligent calibration and analysis; and S5: result output and quality control verification. This method and system achieves simultaneous detection of five core lipid indicators in fingertip blood samples in a short time, with low deviation and cross-interference rates between the detection results and venous blood biochemical detection, and high matrix interference inhibition rate. It also possesses advantages of portability, speed, and accuracy, solving the problems of low detection efficiency, limited applicability, and matrix interference affecting accuracy in existing technologies.
Owner:SHENZHEN DONGYI MEDICAL LAB

Early warning method and system for pheochromocytoma and paraganglioma

The invention provides an early warning method and system for pheochromocytoma and paraganglioma, and is applied to the technical field of data processing. The method comprises the following steps: processing clinical parameters, biochemical marker data and CT image feature data in a training sample set in combination with a Logistic regression analysis method to generate an initial neuroendocrine tumor early warning model; processing the initial neuroendocrine tumor early warning model based on K-fold cross validation and the validation sample set to generate a target neuroendocrine tumor early warning model; processing the biochemical marker data based on 24-hour urine catecholamine pairs in clinical parameters to generate standardized biochemical detection index information; processing the CT image feature data to generate imaging comprehensive score information; and processing the standardized biochemical detection index information and the imaging comprehensive score information based on the target neuroendocrine tumor early warning model to generate early warning information of pheochromocytoma and paraganglioma.
Owner:PEKING UNION MEDICAL COLLEGE HOSPITAL +1